title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Isolation of beta-lactamase from a penicillin-susceptible strain of Staphylococcus aureus. | It is generally accepted that strains of Staphylococcus aureus which are susceptible to penicillin G do not produce beta-lactamase. However, we have found that such a strain susceptible to 0.06 mug of penicillin per ml and 0.56 mug of methicillin per ml produces beta-lactamase(s) which hydrolyzes penicillin G, methicil... | 646,349 | [
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Biocidal properties of anti-icing additives for aircraft fuels. | The biocidal and biostatic activities of seven glycol monoalkyl ether compounds were evaluated as part of an effort to find an improved anti-icing additive for jet aircraft fuel. Typical fuel contaminants, Cladosporium resinae, Gliomastix sp., Candida sp., Pseudomonas aeruginosa, and a mixed culture containing sulfate-... | 646,356 | [
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Primary inoculation tuberculosis of the skin. Prosector's paronychia,. | Subsequent to an autopsy of a tuberculotic cadaver, a pathology resident presented with a painless paronychia and axillary adenopathy after surgical incision and broad-spectrum antibiotics had failed to improve his condition. Demonstration by culture of Mycobacterium tuberculosis var hominis, positive smears, and findi... | 646,369 | [
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Aneurysm of the superficial temporal artery. | An aneurysm of the superficial temporal artery is a rare lesion, which should be suspected after blunt trauma to the forehead that is followed by the appearance of a pulsatile cystic lesion in the region of the superficial temporal artery. Treatment by excision of the aneurysm with ligation of the afferent and efferent... | 646,374 | [
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The epidemiology of scabies in Denmark, 1900 to 1975. | Denmark is the only country in which scabies has been reported for many decades. The present study is based on 850,629 cases reported between 1900 and 1975. The incidence of scabies showed pronounced peaks around 1918 and 1945. Since the end of the 1960s, a new increase in incidence has been observed. The rates were hi... | 646,397 | [
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Aggressive basal cell carcinoma of the scalp. | Three examples of an unusually aggressive form of basal cell carcinoma in the skin of the scalp were treated surgically. The extent of each tumor was verified with gross and microscopic examination. The tumors invaded fat, muscle, fascia, and bone. Dural involvement was seen in one case. Light microscopy showed a marke... | 646,403 | [
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Preventable death in oesophageal atresia. | We report on experience gained in the treatment of 158 cases of oesophageal atresia presenting during a period of 10 years. The factors influencing mortality were analysed. During the period studied there was a slight improvement in survival, and this was probably due mainly to improved preoperative preparation of thos... | 646,439 | [
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Normocalcaemic pseudohypoparathyroidism with unusual phenotype. | We describe a boy who presented at 4 years of age with radiological hyperparathyroidism, osteosclerosis, and necrosis of the femoral heads. Plasma biochemistry was normal but the parathyroid hormone (PTH) level was very high. He was deaf and had an unusual facies but did not have the phenotype of Albright's hereditary ... | 646,442 | [
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Systemic prophylaxis with doxycycline in surgery of the colon and rectum. | A prospective double-blind study on the effects of doxycycline as a prophylactic antimicrobial in elective colonic surgery is presented. One hundred-eighteen patients were evaluated. Fifty-eight were treated and 60 were controls. Two hundred milligrams, doxycycline or placebo (two capsules) were given orally four to si... | 646,474 | [
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Non-mechanical hemorrhage in severe liver injury. | Coagulopathy, or non-mechanical hemorrhage, complicated the operative course of 17 of 33 (51.5%) patients suffering severe liver trauma. The highest incidence of non-mechanical hemorrhage (66.7%) occurred in patients undergoing anatomic lobectomy. Serial hemostatic parameters were assessed and thrombocytopenia was the ... | 646,475 | [
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Microsurgical composite tissue transplantation. | Since 1974, 69 patients with extensive defects have undergone reconstruction by microsurgical composite tissue transplantation. Using this method, donor composite tissue is isolated on its blood supply, removed to a distant recipient site, and the continuity of blood flow re-established by microvascular anastomoses. In... | 646,501 | [
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Delayed mediastinal infection after ventricular aneurysm resection. | A patient developing delayed mediastinal infection following ventricular aneurysm resection and double coronary bypass is presented. The source of sepsis was infection of a ventriculotomy incision that had been closed with Teflon-felt buttresses. Diagnosis was established by an increasing opacity on the lateral chest r... | 646,517 | [
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Effect of lorcainide, a new antiarrhythmic compound, on the changes in heart rhythm induced by intravenous injection of adenosine-5'-diphosphate in rats. | In rats, the intravenous injection of 1 mg/kg A.D.P. (adenosine-5'-diphosphate) results in transient thrombocytopenia, bradycardia and arrhythmias. Pre-treatment of the animals with the antiarrhythmic compounds lorcainide, aprindine, procaine (1.25, 2.5, 5 mg/kg i.v.) and xylocaine (5, 10, 20 mg/kg i.v.) before A.D.P. ... | 646,521 | [
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Competitive antagonism between calcium and aminoglycoside antibiotics on guinea-pig intestinal smooth muscle. | Streptomycin and related aminoglycoside antibiotics and magnesium ions antagonize in a competitive manner the contractile response elicited by calcium ion on the potassium-depolarized guinea-pig ileum. The inhibitory potency decreases in the following way: gentamicin greater than magnesium greater than neomycin greater... | 646,527 | [
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Aseptic necrosis of bone in systemic lupus erythematosus. Relationship to corticosteroid therapy. | The relationship of corticosteroid therapy to the development of aseptic necrosis (AN) in 365 patients with systemic lupus erythematosus (SLE) was investigated. Seventeen patients (4.7%) were identified as having AN. The dosage of corticosteroids ingested during the initial period of therapy in patients with AN was tab... | 646,538 | [
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Allopurinol-induced granulomatous hepatitis with cholangitis and a sarcoid-like reaction. | A 36-year-old man had pain in both knees and an elevated uric acid concentration; his liver function was normal. Allopurinol therapy was started, 100 mg twice daily. After one month fever, lethargy, and severe polyarthralgia developed. On admission to our hospital liver function was abnormal, and a liver biopsy specime... | 646,570 | [
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Rehabilitation outcome of patients with dual disability of hemiplegia and amputation. | The records of 30 patients with the dual disability of hemiplegia and amputation were reviewed. Six factors noted to have influenced the success of rehabilitation were: (1) age; (2) sequence of onset of disability, whether amputation or hemiplegia first; (3) localization of dual disability, whether ipsilateral or contr... | 646,597 | [
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Amputations resulting from electrical injury: a review of 22 cases. | Twenty-two cases of electrical injury with a combined total of 43 major amputations are reviewed. Electrical injury resulting from contact with high-voltage current (greater than 1000 volts) commonly results in significant systemic damage. The purpose of this study was to develop statistical data on the rehabilitation ... | 646,598 | [
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Orthostatic hypotension in amputees and subjects with spinal cord injuries. | Orthostatic examinations were performed with a tilt table on 64 male volunteers, of whom 21 had sustained amputation of one or both lower limbs and 23 were paraplegic due to spinal cord injuries (SCI), with 20 healthy subjects as controls. Following tilting, signs and symptoms of fainting appeared in five of the SCI su... | 646,599 | [
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[Interrater reliability of amp symptoms (author's transl)]. | Two psychiatrists examined 48 patients (25 depressed and 23 schizophrenic). Each documented the symptoms on AMP sheets 3 (psychopathologic symptoms) and 4 (somatic signs, first column only). The study deals with 139 AMP symptoms. Seventy could be judged concerning symptom exists/does not exist. Of these 70 symptoms, 45... | 646,612 | [
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Radioimmunoassayable plasma vasopressin associated with surgery. | Plasma vasopressin concentration was measured by radioimmunoassay before, during, and after anesthesia and surgery in ten subjects. During the short period between the onset of anesthesia and the start of operation, small elevations of vasopressin level were noted. Surgery itself was associated with significant elevati... | 646,620 | [
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Prevention of dermal ischemia after thermal injury. | One percent methylprednisolone acetate was evaluated as a pharmacologic agent in the prevention of dermal ischemia following burning. Standardized partial thickness burns were inflicted on guinea pigs. Burned guinea pigs were separated into five groups; one was treated with topical steroid, one with systemic steroid, o... | 646,624 | [
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Preoperative angiographic diagnosis of small bowel leiomyomas. | Two patients with gastrointestinal (GI) tract bleeding underwent preoperative selective visceral arteriography that demonstrated small-bowel tumors compatible with leiomyoma. A review of the material indicates that 42% of patients with small-bowel leiomyomas also have GI tract bleeding. Arteriography is valuable in obt... | 646,627 | [
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[Microcirculatory bed of the human trigeminal nerve]. | Studies of film preparations from the sheaths of the human trigeminal nerve impregnated with silver nitrate demonstrated all the parts of the microcirculatory bed to be situated in the soft sheath of the root, in the capsule and stroma of the trigeminal ganglion, in epineurium and in the outer layers of perineurium of ... | 646,633 | [
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Multinucleated erythroid cells in blood of golden hamster embryos. | Blood smears of 11 and 13-day-old embryos (20) and newborns (10) of golden hamsters were analysed. The smears were stained with brilliant cresyl blue in a moist chamber for 5--7 min. About 2--6 thousand cells were counted in 200 visual fields. By means of an ocular micrometer MOB-1 the diameters of 300 cells were measu... | 646,656 | [
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[Characteristics of the morphofunctional state of the adrenals in generalized forms of meningococcal infection]. | Changes in the cortical and medullar substances of the adrenals were found to develop in generalized forms of meningococcal infection, the picture of the adrenal involvement changing in relation to the clinical form of infection. In meningococcemia, the leading findings are disturbed circulation and marked affection of... | 646,671 | [
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[Morphology and morphogenesis of recurrent experimental myocardial infarct]. | The results of morphological investigations of relapsing myocardial infarction in 148 rabbits are presented. In most cases the relapses occurred spontaneously at intervals of several to 45 days after reproduction of the primary myocardial infarction by high ligation of the anterior interventricle artery of the heart. I... | 646,672 | [
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[Action of 17-hydroxyprogesterone caproate on the glandular hyperplasia of human endometrium]. | The effect of 17-oxyprogesterone capronate on the proliferative activity and metabolic processes in the endometrium of patients with glandular hyperplasia of the endometrium was studied. It was shown that the proliferative activity was inhibited while the secretory processes in the glandular epithelium were activated. ... | 646,674 | [
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0.2802621,
0.76903,
0.2548157,
-0.089935... |
Response detection in respiration audiometry. | The respiration of ten adults with normal hearing was monitored to determine how well changes in respiration could be detected after auditory stimulation. Three judges used two methods of response scoring. The first was without knowledge of signal presentation, and the second was with knowledge of signal presentation. ... | 646,705 | [
-0.05995511,
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0.3189121,
0.04350004,
0.0682328... |
Ethmoidal mucoceles. | Twenty ethmoidal mucoceles were treated and observed for a minimum of two years after surgery. Unilateral exophthalmos was the initial complaint in all cases and nasal polyposis was a noteworthy finding in more than half of the patients. The lesions always extended into the orbit and usually eroded the floor of the fro... | 646,725 | [
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0.07817403,
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Dominantly inherited low-frequency hearing loss. | Two families with dominantly inherited low-frequency hearing loss are described. The two families are different in mode of transmission and in audiological findings. On the basis of these two differences, it is claimed that two types of inherited low-frequency hearing loss can be distinguished. One type is the dominant... | 646,734 | [
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Accidents in old age. | Elderly persons particularly are liable to falls which in women often cause major fractures and other injuries. In Australia, some two per cent of deaths of women aged 65 and over are attributed to non-traffic accidents, and the length of hospital care and subsequent disability following fractures are both important as... | 646,741 | [
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0.0439... |
Resuscitation at the site of a road accident. | Seven per cent of deaths resulting from motor car accidents are due to asphyxia without any other major injury. This highlights the importance of maintaining an unobstructed airway in patients following motor vehicle accidents. These cases of asphyxia are due to laryngeal spasm, aspirated foreign material, or pharyngea... | 646,743 | [
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First isolation of a Yucaipa-like virus in Africa. | A virus having a hemagglutinin closely related to that of paramyxovirus Yucaipa was isolated from the feces of a wild bird in Senegal, West Africa. | 646,759 | [
-0.02209628,
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0.08206599,
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Sero-epidemiology of Q-fever in poultry. | The sero-epidemiology of Q-fever was studied by capillary agglutination test at 25 poultry farms in the Nainital and Ajmer districts of Uttar Pradesh and Rajasthan. Of 589 birds tested, 78 (13.24%) had Q-fever agglutinins (CAT titers 1:8 to 1:64), involving 16 of the farms. There were more sero-reactors in Ajmer (17.56... | 646,757 | [
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... |
Scanning electron microscopy of damage to the cecal mucosae of chickens infected with Eimeria tenella. | A group of chickens were inoculated with 100,000 Eimeria tenella oocysts each. The birds were sacrificed on days 4-14 postinoculation. Tissue samples from 4 different areas of each cecum examined were obtained and processed by the osmium-thiocarbohydrazide-osmium technique. Examination of the prepared tissues with the ... | 646,764 | [
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0.1974179,
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0.3894273,
0.1094891,
... |
Biochemical genetics of altered acetylcholinesterase resistance to insecticides in the house fly. | Resistance to the organophosphate insecticide tetrachlorvinphos was examined in a house fly (Musca domestica L.) strain with an altered acetylcholinesterase (AChE) of decreased sensitivity to inhibition by the insecticide. Genetic tests showed that both resistance and the altered AChE were controlled by semi-dominant g... | 646,783 | [
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Protein degradation rates in regions of the central nervous system in vivo during development. | The rate of protein degradation was estimated in several regions of rat brain at various ages by subtracting the rate of accumulation of protein from the rate of synthesis. The rate of degradation in cerebral hemisphere, which was 1.3%/h at 2 days of age, declined steadily with age, approaching the synthesis rate is ab... | 646,805 | [
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DNA polymerases from Chlamydomonas reinhardii. Further characterization, action of inhibitors and associated nuclease activities. | The properties of three DNA polymerase species A, B and C, purified from Chlamydomonas reinhardii were compared. DNA polymerases A and B have Km values with respect to deoxyribonucleoside triphosphates of 19 micron and 3 micron respectively. DNA polymerase A is most active with activated DNA, but will also use native D... | 646,818 | [
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0.07437... |
Kinetics of tetrahydrobiopterin synthesis by rabbit brain dihydrofolate reductase. | Product identification and kinetic data are presented for the conversion of 7,8-dihydrobiopterin into tetrahydrobiopterin by purified rabbit brain dihydrofolate reductase. | 646,819 | [
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Characterization of monoferric fragments obtained by tryptic cleavage of bovine transferrin. | 1. The electrophoretically fast (F) and slow (S) fragments obtained by tryptic cleavage of bovine iron-saturated transferrin differed in carbohydrate content and peptide 'maps'. 2. A fragment capable of binding one Fe3+ ion per molecule was isolated after brief tryptic digestion of bovine apotransferrin and shown close... | 646,825 | [
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Idiopathic multicentric osteolysis. Report of an affected father and son. | Genetic, rheumatologic, immunologic, metabolic, and renal studies of a father and son with idiopathic multicentric osteolysis are reported. The disorder appeared through mutation. The father developed symptoms as an infant, his son at age 4 years and 9 months. Both have micrognathia and hypotelorism and were exceptiona... | 646,835 | [
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Fibrinogenemia, determined immunonephelometrically, as a possible parameter in the evaluation of peripheral arteriosclerotic arteriopathy. | The concentration of plasma fibrinogen increases with age and is particularly elevated in subjects with vascular changes due to atherosclerosis. Fibrinogen, which is the meeting point of the "cascade" of the coagulation factors and an important regulating factor of plasma viscosity, occupies a key position in atheroscl... | 646,850 | [
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... |
The structure of hemoglobin Hopkins-2. | Hemoglobin Hopkins-2 was originally reported to contain two abnormal alpha chains. Both had aspartic acid instead of the normal histidine at position alpha 112; the second alpha chain also contained two additional amino acid substitutions. In subsequent reports of the structure of this hemoglobin, only the His replaced... | 646,867 | [
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Successful treatment by overdrive pacing of recurrent quinidine syncope due to ventricular tachycardia. | A 54 year old patient who experienced recurrent ventricular tachycardia subsequent to quinidine administration for conversion of atrial fibrillation is described. Over a 10 hour period, 25 sustained episodes of ventricular tachycardia occurred for which electrical cardioversion was required in addition to numerous self... | 646,873 | [
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-0.1430738... |
Anterior border of the left atrium on conventional heart films. | The appearance of the anterior left atrial wall on conventional lateral chest films is presented. The position of this structure is often marked by fatty tissue surrounding the posterior wall of the ascending aorta. A markedly enlarged left atrium may overlap the aorta. The delineation of the anterior border is still s... | 646,876 | [
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0... |
[Skin response to phytohemagglutinin in patients with typhoid fever, bronchial asthma and Hodgkin's disease]. | The skin response to phytohemagglutinin was investigated as an index of cellular immunity in group of 50 children made up of 11 with thypoid fever, 13 with bronchial asthma type I, 15 with Hodgkin's disease and 11 controls. A mild but statistically significant (p less than 0.005) depression was found in the skin respon... | 646,883 | [
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Pleuropulmonary amoebiasis in Ghana: a report of three cases. | Three cases of pleuropulmonary amoebiasis are reported for the first time from Ghana. It is suggested that where facilities for identification of the causal agent are not available a therapeutic trial should be given with drugs effective against Entamoeba histolytica. | 646,939 | [
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... |
The effects of glucocorticoids on cultured human endothelial cells. | The effects of hydrocortisone, dexamethasone and prednisone on the morphology, replication, DNA synthesis, cell protein content and protein synthesis of cultured, human endothelial cells were evaluated. After culturing the cells with these glucocorticoids for 24-48 h, the cells covered a greater portion of the culture ... | 646,949 | [
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... |
Mobilization of iron from the plasma membrane of the murine reticulocyte. The role of ferritin. | 1. Plasma membranes prepared by pre-incumbation of mouse reticulocytes with 125I, 59Fe-labeled murine transferrin were able to release 59Fe in preference to 125I when incubated in the presence of murine reticulocyte cytosol, demonstrating that the latter mobilized iron which had been dissociated from transferrin. 2. 59... | 647,005 | [
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Effects of bile salts of human erythrocytes. Plasma membrane vesiculation, phospholipid solubilization and their possible relationships to bile secretion. | Glycocholate removed approximately 25% of the membrane acetylcholinesterase and 10% of the membrane phospholipid from intact human erythrocytes prior to the onset of cell lysis. At low concentrations (up to 6 mM), glycocholate caused human erythrocytes to become echinocytic and to pinch off microvesicles, whereas at hi... | 647,007 | [
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The role of gamma-carboxyglutamyl residues in the positive cooperative binding of Ca2+ to blood coagulation factor X. | 1. The calcium binding properties of factor X and its analogous decarboxyprotein have been compared with the aid of flow rate dialysis and ultraviolet difference spectroscopy. 2. Factor X binds approx. 20 mol of calcium per mol of protein. The first four sites exhibit positive cooperativity. 3. Changes in the ultraviol... | 647,012 | [
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Quantitation of submicrogram quantities of protein by an improved protein-dye binding assay. | A quantitative assay method for protein is described which is based on the color change occurring in Coomassie Brilliant Blue G-250 when it binds to protein. This modification of two similar procedures further increases the sensitivity, simplicity, and stability of the protein-dye binding assay over those of other comm... | 647,023 | [
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... |
Conformation of oxytocin studied by laser Raman spectroscopy. | The peptide backbone conformation and salient structural details of oxytocin were examined by laser Raman spectroscopy. Spectra were obtained in the solid phase, water, 2H2O, and dimethyl sulfoxide solutions. A distinct Amide I band was obtained at 1663 cm-1 for aqueous and deuterated samples and 1666 cm-1 for the soli... | 647,024 | [
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0.177222,
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[Model studies of lateral inhibition as a mechanism of detecting motion. II. Modeling feedback inhibition]. | A program is worked out which imitates non-stationary lateral inhibition in two-dimensional retina with physiologically real characteristics. Experiments with moving and flashing stimuli of different size are carried out. It is shown that lateral inhibition may serve as a mechanism which forms selective sensitivity of ... | 647,046 | [
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... |
Interactions of cis- and trans-platinum(II) complexes with dehydrogenase enzymes in the presence of different mono- and polynucleotides: evidence for a ternary complex. | The inhibition of several dehydrogenase enzymes by cis- and trans-Pt(NH3)2Cl2 have been measured in the presence of baker yeast ribonucleic acid (RNA), calf thymus and salmon sperm deoxyribonuclic acid (DNA) and several mononucleotides (AMP and ATP). The binding constants for the interaction of the platinum complexes t... | 647,061 | [
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-0.2414602,
0.2502374,
0.3414334,
-0.1942445,
-0.1722461,
... |
[Interconversions of ubiquinone and ubichromenol in rat liver under the effect of alpha-tocopherol]. | Incubation of ground liver preparation isolated from vitamin E-deficient rats resulted in correlated in time changes of ubiquinone and ubichromenol contents and their ration in tissues. A suggestion is made on the possibility of ubiquinone and ubichromenol interconversions and of the existence of a system controlling (... | 647,072 | [
-0.1378652,
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0.4593623,
0.2951304,
0.1135557,
-0.0... |
[On the impossibility of the incorporation of 5-methylcytosine and its nucleosides into higher plant DNA]. | No radioactivity was detected in 5-methylcytosine isolated from wheat DNA after incubation of wheat seedlings with 3H-labelled 5-methylcytosine, 5-methylcytidine and 5-methyldeoxycytidine. No label from 3H-5-methylcytosine was found in DNA of seedlings. After incubation of seedlings with 3H-labelled nucleosides of 5-me... | 647,074 | [
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0.3549686,
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0.2959151,
0.7578643,
0.1703997,
-0.1671059,
... |
[The aminoacyl phosphatidyl glycerols of the plastid membrane system in the process of chloroplast biogenesis]. | The composition of aminoacyl phosphatidyl glycerols in maize plastids at different stages of chloroplast differentiation has been studied. In the course of incubation of 14C amino acids or 14CO2 with maize and bean seedlings in vivo the 14C amino acids were incorporated preferably into the acid phospholipid fraction, f... | 647,080 | [
0.09841329,
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0.6672814,
0.508201,
-0.1700678,
... |
Bilateral electrodermal activity in depressive patients. | Integrated bilateral skin conductance response and reactive lateral eye movements were studied in 19 depressive patients and 14 normal subjects during visual and verbal tasks and tone habituation sequence. Distinct right-left differences between depressed and normal subjects in reactive lateral eye movements were revea... | 647,086 | [
-0.1446411,
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0.07519295,
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Interaction of phenosafranine with nucleic acids and model polyphosphates. I. Self-aggregation and complex formation with inorganic polyphosphates. | Aggregation of phenosafranine in concentrated aqueous solutions and interaction with polyphosphates was studied by absorption and fluorescence spectroscopy. At concentrations greater than 10(-3)M phenosafranine forms dimers (Kd = 3.8 x 10(2) 1.mole-1), which are characterized by a hypsochromic shift of the visible and ... | 647,100 | [
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0.1895551,
... |
Failure of the alpha-thalassemia gene to decrease the severity of sickle cell anemia. | A 15-yr-old black male with homozygous sickle cell disease was severely growth retarded and had a chronic hemolytic anemia requiring transfusions. Globin chain synthetic studies of both peripheral blood reticulocytes and bone marrow cells revealed a ratio of alpha to betas globin synthesis (alpha/betas ratio) of 0.5, i... | 647,121 | [
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0.1017658,
0.6666536,
0.2044643,
0.009887... |
Monovalent cation composition and ATP and lipid content of irreversibly sickled cells. | Discontinuous Stractan gradients were used to separate heterogeneous populations of sickle cells into discrete subpopulations containing varying proportions of reticulocytes, mature discoid cells, and irreversibly sickled cells (ISC). The improved homogeneity of these preparations, together with an enhanced yield of IS... | 647,122 | [
0.01870551,
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0.01638868,
0.006635054,
0.6560483,
0.1136422,
0.0408623... |
Effects of propylbenzilylcholine mustard on injection into the liquor space of cats. | In unanaesthetized cats the effects were examined of propylbenzilylcholine mustard (PrBCM) on injection into the cannulated cerebral ventricles and cisterna magna. Extreme motor excitation, vocalization, shivering leading to fever, tachypnoea, panting, piloerection and salivation were produced on ventricular, vigorous ... | 647,161 | [
-0.1604532,
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0.05817447,
... |
Reducing multiple problem behaviours in a profoundly retarded child. | The purpose of the present paper is to describe two behaviour management programmes developed for a profoundly retarded child in a special education classroom. The target behaviours were:(1)inappropriate object contract,(2)wild running about the room, and(3)consistent refusal to eat. Literature was reviewed in an effor... | 647,170 | [
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A computer simulation study of optimal thyroid radiation protection during investigations involving the administration of radioiodine-labelled pharmaceuticals. | The administration of iodide for thyroid blocking is now known to carry its own risks, at least in certain categories of patients. We have therefore made a theoretical study by computer simulation of the efficacy of various thyroid blocking regimes. In the case of injected 125I- or 131I-iodide, substantial thyroid prot... | 647,182 | [
-0.2811916,
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The therapeutic advantage of combined heat and X rays on a mouse fibrosarcoma. | The response of an experimental fibrosarcoma to combined heat and X rays has been assessed using delay in tumour regrowth. No thermal sensitization was observed for one hour of heating at 41.5 degrees C. A thermal enhancement ratio of 1.4 to 1.5 was seen for one hour of heating at 42.5 or 43.5 degrees C immediately aft... | 647,188 | [
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Causes of failure in the surgical treatment of primary hyperparathyroidism: lessons from 51 successful reoperations. | A review of 51 successful reoperations for persisting hypercalcaemia due to primary hyperparathyroidism shows that inadequate anatomical knowledge, inadequate surgical technique and unusual localizations of the parathyroids are the most frequent causes of failure of the primary operation. The majority of these failures... | 647,190 | [
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Intestinal ischaemia associated with ileal carcinoid tumours. | A case of intestinal infarction due to multiple ileal carcinoid tumours is presented in which abdominal pain due to intestinal ischaemia was the first manifestation of the underlying tumour. It is postulated that intestinal ischaemia may be of more importance in the production of abdominal pain by carcinoid tumours tha... | 647,194 | [
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... |
Drug therapy in intermittent claudication: an objective assessment of the effects of three drugs on patients with intermittent claudication. | It has been suggested that, by reducing the viscosity of blood, flow through capillaries is increased with consequent improvement in the symptoms of patients with peripheral vascular disease. We examined the effects of treatment with drugs purported to reduce blood viscosity to test the validity of this claim. Measurem... | 647,201 | [
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The treatment of early colorectal cancer by local excision. | An analysis is presented of 143 patients with early colorectal carcinoma treated by local excision between 1948 and 1972 at St Mark's Hospital. The tumours are considered in three groups; colonic tumours, pedunculated rectal tumours and non-pedunculated rectal tumours. The importance of careful clinical assessment and ... | 647,202 | [
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0.035696... |
Popliteal vein entrapment. | A case of popliteal vein entrapment by an abnormal 'third' head of the gastrocnemius muscle is reported. Complete relief of disabling symptoms was obtained by dividing the abnormal muscle band. | 647,204 | [
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High prevalence of hyperuricaemia and gout in an urbanised Micronesian population. | The prevalence of hyperuricaemia and gout was investigated in the Micronesian inhabitants of the highly urbanised central Pacific island of Nauru. Sixty-four per cent of men and 60% of women aged 20 years and over had hyperuricaemia--the highest prevalence rates yet reported for a population. The hyperuricaemia in men ... | 647,212 | [
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... |
How patients use domiciliary oxygen. | Forty-five patients in Southampton who received domiciliary oxygen were visited at home to find out how they used and coped with their oxygen. Generally, the organisation and administration of supplies presented no problems, nearly all the apparatus complied with the drug tariff, and most patients coped well with the e... | 647,308 | [
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0.04561895,
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0.22666... |
Evidence for intestinal origin of transcobalamin II during vitamin B12 absorption. | The plasma binding of newly absorbed, radioactively labelled vitamin B12 was studied during a urinary excretion (Schilling) test. Vitamin B12, after being absorbed from the gut, enters blood attached to transcobalamin II, which seems to be derived from the ileal enterocyte. The absorbed B12 re-enters the blood stream a... | 647,333 | [
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Abnormal recrossing retinotectal projections after early lesions in Syrian hamsters: age-related effects. | If the superficial layers of the right superior colliculus (SC) of a newborn hamster are removed, fibers from the left eye not only terminate in the surviving deeper layers of the right SC, but also cross the tectal midline and terminate in the medial third of the left SC. If the right eye is also removed at birth, the... | 647,401 | [
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Transient heterosynaptic depression in the hippocampal slice. | Two independent, excitatory, monosynaptic afferent fiber systems projecting onto basal and apical dendritic layers of the CA1 sub-field of the hippocampus were tested for interactive effects. Long-term potentiation of either of the pathways was accompanied by a transient depression in the other pathway. Similar transie... | 647,417 | [
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Scanning electron microscopical study on the fluorosis of enamel in rats. | Sixteen 28-day-old male rats of Wistar strain, with a mean body weight of 179 g, were divided into two equal groups. Each group of eight animals was maintained for 70 days on drinking water, ad lib., containing no fluorine (control group) and 100 ppm of fluorine (experimental group). All specimens examined were obtaine... | 647,440 | [
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0.340233,
-0.205554... |
Bordetella rhinitis in pigs: serum and nasal antibody response to Bordetella bacterins. | The nasal and serum antibody response of two groups of pigs, vaccinated with adjuvant containing formalinized or sonicated Bordetella bronchiseptica bacterins was compared with the response of a nonvaccinated group. The tube agglutination test was used to determine agglutinin titers. Following vaccination, all pigs wer... | 647,455 | [
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Acute urea toxicity in sheep. | Twenty-seven sheep were assigned to three groups in order to study acute urea toxicity. Groups I, II and III were dosed with 0.5, 0.6 annd 0.75 g/kg of urea, respectively. The mean survival times were 165, 109 and 60 minutes, respectively. The following clinical signs such as pronounced muscle fasciculation, trembling,... | 647,459 | [
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0.5387465,
-0.1788976... |
Senile disciform macular degeneration and smoking. | We studied the smoking habits of 114 patients with senile disciform degeneration of the macula. The mean age at onset of blindness in the first eye was 64 years in those currently smoking; this was significantly less than the mean age in those who had never smoked (71 years). We advise all patients with disciform degen... | 647,465 | [
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Cleavage planes in the envelope of Aquaspirillum bengal. | The cell surface of Aquaspirillum bengal was devoid of superficial wall structure. When cells were freeze-cleaved and etched, multiple fracture planes through the cell envelope were exposed, which was unusual for an aquaspirillum. These included both convex and concave surfaces and they are compared with those of other... | 647,474 | [
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... |
Breakdown of psyllium hydrocolloid by strains of Bacterioides ovatus from the human intestinal tract. | Strains of Bacteroides ovatus from human feces produced extracellular enzymes which degraded psyllium hydrocolloid. Other species of saccharolytic bacteria which are found in high concentrations in human feces did not degrade psyllium. | 647,481 | [
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Cerebellar ataxia produced by 3-acetyl pyridine in rat. | A single intraperitoneal injection of 3-acetyl pyridine produces, within 24 hours of administration, signs of cerebellar ataxia and damage to the medulla oblongata and to the climbing fibers of the cerebellum. These changes are accompanied by changes in the concentration of certain amino acids in the appropriate areas.... | 647,489 | [
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0.1553793,
-0.04990409,
0.2279957,
0.02187932,
0.2673659,
0.4063681,... |
Microvascular anastomosis for cerebral ischemia in 19 patients: a preliminary report. | The general principles of bypass surgery as they affect the cerebral circulation are reviewed. The preliminary results of an extracranial intracranial bypass operation performed on a group of 19 patients suffering from cerebral ischemia are presented. The results of the surgery compare favorably with those published in... | 647,494 | [
-0.2850193,
0.1714196,
-0.06205947,
-0.2188801,
0.1465535,
-0.1976219,
-0.2057154,
-0.2932067,
-0.1591025,
0.1684726,
-0.03325755,
0.09383615,
0.001949008,
-0.2377677,
-0.3610246,
-0.198433,
-0.03315992,
0.2042373,
-0.2013608,
0.1779772,
0.1952581,
0.1906625,
0.3010572,
... |
Annular pancreas: a new classification and clinical observations. | Seven cases of annular pancreas are described. In all the diagnosis was confirmed at autopsy or at operation. This study provides a new, original classification for annular pancreas. Two distinct subtypes are described: type 1, extramural and type 2, intramural. In type 1 the presenting symptoms are those of high gastr... | 647,515 | [
-0.1637251,
-0.2628694,
-0.09160703,
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0.0693941,
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0.3369463,
0.1820141,
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-0.01332443,
0.324396,
-0.4589079,
-0.02124773,
0.2456341,
-0.1319439,
0... |
Puerperal uterine inversion: report of nine cases. | Acute puerperal inversion of the uterus is considered to be rare. In one institution there were nine cases during an 11-year period, a rate of one for every 2176 vaginal deliveries. Analysis of these cases failed to identify any contributing factors occurring during the first or second stage of labour. Six cases were d... | 647,547 | [
-0.2295779,
0.2716914,
-0.3201267,
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0.4114096,
-0.2409168,
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-0.1302316,
0.2990967,
0.1251706,
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0.1877701,
-0.4268006,
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0.2175285,
0.2764269,
-0.2823377,
... |
Hyperactive individuals as young adults: current and longitudinal electroencephalographic evaluation and its relation to outcome. | In a 10-year follow-up study electroencephalograms (EEGs) of 31 hyperactive and 27 matched control subjects of mean ages 19.17 and 18.59 years respectively showed no significant differences in any of the features assessed. Sequential EEGs, available for only the hyperactive subjects, suggested that a much greater propo... | 647,563 | [
-0.0305882,
0.147301,
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-0.3664025,
0.152648,
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-0.3177751,
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0.02095588,
0.2751314,
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0.3235601,
-0.4145631,
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-0.2145071,
0.3446875,
-0.09578496,
-0.08999185,
0.251554,
0.1739721,
-0.00190312,
... |
The use of dreams in psychotherapy: practical guidelines. | Although there is a large literature pertaining to the use of the dream in psychoanalysis, there is no systematic approach to working with dreams in psychotherapy. This communication seeks to present some guidelines for the use of the dream in psychotherapy. Reference is made to the significant difference in the "dimen... | 647,613 | [
-0.3189949,
0.2023669,
-0.1393207,
-0.1615478,
0.2530181,
-0.08425958,
-0.07576028,
-0.1639888,
0.2412554,
-0.1074792,
0.08771023,
0.04215572,
-0.3376817,
-0.1700789,
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-0.2031651,
0.1066117,
-0.3644668,
-0.08326261,
0.07095218,
0.1942154,
-0.030984... |
The microcirculation in two transplantable melanomas of the hamster. II. Scanning electron microscopy. | Normal and tumor vessels observed in vivo on the hamster cheek pouch membrane in transparent chambers were examined by scanning electron microscopy. Large, thin walled veins were found in the reactive zone around the 2 amelanotic melanomas of the hamster. Sinusoidal vessels and channels contained red cells, which did n... | 647,651 | [
-0.1341157,
-0.1701346,
-0.6203046,
0.0441831,
0.02957534,
-0.2286252,
-0.1229552,
0.3332146,
0.375923,
-0.0589516,
0.1519939,
-0.3743619,
-0.1003386,
-0.2976049,
-0.6019369,
-0.02120527,
0.07204032,
-0.2540351,
0.0375903,
0.1805754,
0.5905194,
0.2719442,
-0.02147523,
0... |
Metabolism of benzo(a)pyrene in animals with high aryl hydrocarbon hydroxylase levels and high rates of spontaneous cancer. | Ambystoma tigrinum found in a sewage polluted pond had high levels of aryl hydrocarbon hydroxylase (AHH) activity that decreased to the basal level of control animals after being held several months in clean water. The qualitative formation of benzo(a)pyrene (BP) metabolites by salamander hepatic microsomes was similar... | 647,652 | [
-0.3079886,
-0.04213227,
-0.4413659,
-0.252833,
-0.260754,
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-0.4478115,
0.04644631,
0.1312824,
-0.1130184,
0.1585956,
-0.08213885,
-0.1990708,
-0.09392925,
0.01782193,
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-0.681517,
0.1669412,
0.2016816,
0.1120196,
0.1121371,
0.4868698,
-0.006567162,
... |
Tumor induction in the trachea of hamsters with N-nitroso-N-methylurea. | Experiments were conducted to study the tumor response of hamster tracheas to N-nitroso-N-methylurea. Tracheas were exposed repeatedly with the use of a tracheal catheter. Ten to 30 exposures were given over a period of 5 to 20 weeks. The carcinoma incidence (including carcinoma in situ) was 0,42, 67, 88, and 94% for 1... | 647,678 | [
-0.1177294,
-0.2391055,
-0.4574623,
-0.2644751,
0.1232696,
-0.4047176,
-0.2066343,
-0.04933538,
0.2361467,
0.2119291,
0.2052129,
0.0690098,
-0.03435462,
-0.1772378,
-0.05630725,
0.04518507,
-0.5995504,
0.2199103,
-0.04791902,
-0.007156952,
0.4968173,
-0.02381956,
-0.01008... |
Biological activity and metabolism of the retinoid axerophthene (vitamin A hydrocarbon). | Biological properties of axerophthene, the hydrocarbon analog of retinol, have been studied both in vitro and in vivo. In tracheal organ culture axerophthene reversed keratinization caused by deficiency of retinoid in the culture medium; its potency was of the same order of magnitude as that of retinyl acetate. Axeroph... | 647,683 | [
-0.075844,
-0.4344244,
-0.4264094,
0.04742071,
0.07142076,
0.0196155,
-0.3093031,
0.08971574,
0.07878388,
-0.02454018,
0.3848824,
-0.03137961,
0.1596227,
0.01721331,
-0.0565671,
0.275292,
-0.7940282,
-0.03870066,
0.2670666,
-0.03152133,
0.4636719,
0.3825639,
-0.0907618,
... |
Evidence for bay region activation of chrysene 1,2-dihydrodiol to an ultimate carcinogen. | The tumor-initiating activities of chrysene and the three metabolically possible trans-dihydrodiols at the 1,2-, 3,4-, and 5,6-positions of chyrsene were determined on the skin of female CD-1 mice. A single topical application of 0.4, 1.25, or 4.0 mumol of each compound was followed 7 days later by twice-weekly applica... | 647,691 | [
-0.2348987,
0.1359904,
-0.2186042,
-0.2748962,
0.1535938,
-0.09670229,
-0.1956504,
-0.1063874,
0.277597,
0.289109,
0.01581276,
-0.1871356,
0.1307842,
-0.09151647,
-0.5973195,
-0.1100539,
-0.4339497,
0.1712519,
0.3911206,
0.07976502,
0.3964443,
0.5218663,
-0.2369348,
0.0... |
Synthesis and antitumor activity of 4-demethoxyadriamycin and 4-demethoxy-4' -epiadriamycin. | Two new analogs of adriamycin have been obtained by chemical synthesis, 4-demethoxyadriamycin and 4-demethoxy-4' -epiadriamycin. Both compounds were highly effective against experimental mouse tumors at doses about ten times lower than those effective for adriamycin. At the optimal dose, 4-demethoxyadriamycin displayed... | 647,696 | [
-0.4037869,
0.3505372,
-0.002636686,
-0.2954535,
0.166529,
0.2415177,
-0.2010234,
-0.02616991,
-0.08300707,
0.05035692,
-0.1015593,
-0.0002046134,
0.1048111,
0.1778974,
-0.375135,
0.02104535,
-0.1775667,
0.3382026,
0.02248669,
0.3073108,
0.3302281,
0.01588362,
-0.2207314,... |
Primary cultures of dispersed cells of rat pineal gland. I. Fine structure and indole metabolism. | In vitro indole metabolism and ultrastructural morphology of the pineal gland of male rats were examined. A comparison of the effect of norepinephrine stimulation on indole synthesis in whole cultured glands and preparations of dispersed pineal cells is discussed. Our studies on the performance of dispersed cells durin... | 647,753 | [
0.04490235,
-0.002570635,
-0.1718822,
-0.1500456,
0.03226903,
-0.3614168,
-0.3383316,
0.297373,
0.1637228,
0.1069235,
0.1138751,
-0.01275987,
-0.2261359,
-0.1073899,
-0.5819159,
0.02473339,
-0.3553755,
0.1761792,
-0.00441701,
0.3137282,
0.4113622,
0.166832,
-0.2126876,
... |
The juxtaglomerular apparatus of rats with hereditary hypothalamic diabetes insipidus. | The juxtaglomerular apparatus (JGA) of rats with hereditary hypothalamic diabetes insipidus (DI) was studied. Plasma concentration of renin and angiotensin II, as well as serum sodium concentration and serum osmolality of DI rats are elevated. The morphological examination reveals no characteristic alteration of the ep... | 647,755 | [
0.04093851,
-0.2245174,
-0.2231684,
-0.1750448,
-0.07518873,
-0.4908301,
-0.2640531,
0.1190238,
0.3899107,
0.4962788,
0.3619858,
-0.1644432,
-0.2820767,
-0.4375118,
-0.6690527,
0.1229536,
0.004220805,
0.2195291,
0.04916143,
-0.06878922,
0.379387,
-0.03348685,
0.1261125,
... |
Extrinsic compression of the heart by tumor masquerading as cardiac tamponade. | A patient with known intrathoracic tumor presented with findings suggestive of cardiac tamponade. At cardiac catheterization, the entire heart was displaced superiorly and anteriorly by the tumor mass, and this accounted for the observed cardiac hemodynamics, in the absence of discernible pericardial effusion. | 647,777 | [
-0.523179,
0.1022323,
-0.1882713,
-0.3800034,
-0.08191458,
-0.16382,
-0.3946947,
-0.1116877,
-0.09333234,
0.03238181,
0.2284777,
0.4255241,
-0.1696508,
-0.1497034,
-0.09867432,
-0.09747477,
-0.4565749,
-0.09198754,
-0.08275584,
-0.366549,
0.070834,
-0.1277728,
-0.218271,
... |
Activation of the alternative pathway of complement by grain. I. C3PA conversion and quantification of complement consumption by rye. | Ground whole rye and airborne rye dust of comparable size distribution were tested for their ability to activate the complement cascade via the alternative pathway. Precipitin-negative pooled normal human serum was incubated with increasing amounts of the two rye dusts. Electrophoresis of the resultant supernatant flui... | 647,896 | [
-0.157947,
0.2935642,
-0.06122231,
0.07535101,
0.07725485,
-0.03300627,
-0.04568987,
-0.04131023,
0.2135361,
0.3552465,
0.06665123,
0.01140163,
0.158198,
-0.0460644,
-0.2259715,
0.1419014,
-0.2977713,
-0.1404814,
-0.1436452,
0.02603851,
0.1695186,
0.4456849,
0.2631797,
... |
Evaluation of the JET technique for extracting drugs from urine. | A rapid extraction method preliminary to analysis for drugs in urine is described. Extraction columns containing purified cotton fiber (JETUBE, Manhattan Instrument Co., Santa Monica, Calif.) are shown to give high (approximately 90-97%) extraction efficiencies for some commonly prescribed or abused drugs, notably phen... | 647,917 | [
0.05116851,
0.3586476,
-0.4195912,
0.2613193,
0.1357348,
-0.2917476,
-0.3787875,
0.1356679,
0.1613067,
-0.2567839,
0.04282558,
-0.2376051,
0.3110094,
0.08609827,
-0.2629265,
-0.05245408,
-0.3399929,
0.3031836,
-0.07306606,
-0.06782045,
0.567718,
-0.05834372,
0.0982233,
... |
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