title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Response of malignant melanoma to plasma exchange, surgical debulking, and Corynebacterium parvum. | A 48 year old man with extensive cutaneous and subcutaneous metastatic malignant melanoma responded to treatment by repeated plasma exchanges, partial surgical debulking of tumor masses, and intravenous Corynebacterium parvum. Circulating immune complexes were measured by the serum C1q binding method. Tumor regression ... | 669,835 | [
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Recent changes in the morphology of gastric cancer in Japan. | The macroscopical and histological features of 4,428 cases of gastric cancer resected stomachs was noted.d surgically between 1953 and 1974 were studied. Of these cases, 81.9% were in an advanced stage and 18.1% in an early stage. The following changes were observed. (1) In the group of advanced cancers, a gradual decr... | 669,846 | [
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Abnormalities of chromosome No. 1 in human solid malignant tumours. | Marker chromosomes involving chromosome No. 1 were studied with banding techniques in 10 primary solid tumours. Structural or numerical aberrations of chromosome No. 1 were found in nine of these. Two major types of rearrangement of chromosome No. 1 were observed: translocation of the long arm (partial trisomy) and an ... | 669,851 | [
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Effects of Corynebacterium parvum and cortisone on the primary Lewis tumour and its metastases. | The effects of Corynebacterium parvum and cortisone acetate (CA) on the primary Lewis lung carcinoma and its pulmonary metastases were investigated. C. parvum given IV either on the same day or 7 days after tumour inoculation, reduced primary tumour growth, while 2.5 mg CA (high-dose) given SC 4 and 11 days after tumou... | 669,856 | [
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Multiple drug abuse: examination of drug-abuse patterns in male prisoners. | Preincarceration drug-use patterns were investigated retrospectively in 58 male prisoners, average age 18.6 years, of whom 50% were White, 43% Black, and 7% Hispanic. Fifty-five percent were classified as drug-dependent, 36% as regular, and 9% as casual users of at least one drug. Classification according to numbers o... | 669,867 | [
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Preparation of protected peptide hydrazides from the acids and hydrazine by dicyclohexylcarbodiimide-hydroxybenzotriazole coupling. | A mild procedure for preparing protected peptide hydrazides directly from the corresponding carboxylic acids and equivalent amounts of hydrazine, N-hydroxybenzotriazole and dicyclohexylcarbodiimide is described. Side reactions frequently encountered in hydrazinolysis are thus totally avoided. The process is especially ... | 669,886 | [
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Chromosomal proteins. The amino terminal sequence of high mobility group non-histone chromosomal protein HMG 14, showing sequence homologies with two other chromosomal proteins. | The amino acid sequence of the first 33 residues of the non-histone chromosomal protein HMG 14 has been determined. The presence of two regions of common sequence between HMG 14 and both the non-histone chromosomal protein HMG 17 and the trout specific protein, H 6, is noted. | 669,887 | [
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Television pupillometry via digital time processing. | A new modification of the dynamic, infrared recording pupillometer of the closed-circuit television type has been developed, utilizing recent developments in high speed electronic counters. The pupillometer is simple and reliable in operation, has excellent response characteristics, and can be used over a broad range o... | 669,901 | [
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Mechanism for transport of nitro-blue tetrazolium into viable and non-viable leukocytes. | The permeability of the membrane of phagocytic leukocytes (WBC) to the non-complexed nitro-blue tetrazolium (NBT) cation has not been well explored. In this study both complexed and non-complexed (or free) NBT have been incubated with viable cells. The entry of NBT into the WBC was determined by both colorimetric and i... | 669,990 | [
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Ventilatory response to medroxyprogesterone acetate in normal subjects: time course and mechanism. | The time course of ventilatory adaptation to medroxyprogesterone acetate (MPA) and potential mediators of this response in plasma and lumbar CSF were determined in five healthy adult males. A significant decrease in arterial PCO2 (PACO2) at rest and exercise was noted within 48 h of drug administration with the maximum... | 670,006 | [
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Respiratory responses to intravenous and intrapulmonary CO2 in awake dogs. | Ventilatory responses to CO2 inhalation and CO2 infusion were compared in the awake dog. The CO2 was introduced directly into the systemic venous blood via a membrane gas exchanger in a femoral arteriovenous shunt circuit, and the extracorporeal blood flow, QX, was maintained constant at one of two rates: low, 0.5 l/mi... | 670,022 | [
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Carbon dioxide--a major determinant of collateral ventilation. | The effects of local or systemic CO2 and changes in pulmonary vascular pressure and flow on the mechanics of collateral ventilation were studied in anesthetized, paralyzed dogs. The resistance to collateral ventilation (Rcoll) decreased by 36.1% when the air being infused into the obstructed segment was replaced with 1... | 670,035 | [
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Leiomyosarcoma of the canine urinary bladder, with metastases. | An enlarged nodular mass, assumed to be the prostate gland because of location and consistency, was palpated in the pelvic region of a 10-year-old German Shepherd Dog. Castration was performed as a therapeutic procedure after an estrogenic hormone failed to reduce the size of the mass. A tumor identified histologically... | 670,046 | [
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The presence of ribosomal glycoproteins. Agglutination of free and membrane-bound ribosomes from wheat germ by concanavalin A1. | Free and membrane-bound ribosomes prepared from wheat germ and extensively washed with 1% Triton X100-sodium deoxycholate, formed large aggregates in the presence of concanavalin A. The ribosomal aggregates were detected by sucrose density gradient centrifugation and immunoprecipitation. SDS-polyacrylamide gel electrop... | 670,156 | [
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Isolation and amino acid sequence of the alpha-subunit of follicle-stimulating hormone from equine pituitary glands. | Six hundred milligrams of follicle-stimulating hormone (FSH), containing 110 NIH-FSH-S1 units/mg, was isolated from 9 kg of equine pituitary glands. The equine FSH was dissociated into alpha- and beta-subunits. A tentative amino acid sequence of the alpha-subunit was determined. The alpha-subunit contained 82 amino aci... | 670,201 | [
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Identification of a binary complex of procarboxypeptidase A and a precursor of protease E in porcine pancreatic secretion. | In porcine pancreatic secretion procarboxypeptidase A exists in two states: as a monomer and as a binary complex of a type hitherto not observed in the pancreatic secretions of other species. This complex is shown to contain 1 molecule of procarboxypeptidase A and 1 molecule of a proteolytic zymogen we have designated ... | 670,212 | [
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Enzymatic synthesis of a glucose-containing oligosaccharide-lipid involved in glycosylation of proteins. | Earlier studies on the biosynthesis of an oligosaccharide-lipid with the structure (alpha-Man)4-6-beta-Man-(1 leads to 4)-beta-GlcNAc-(1 leads to 4)-GlcNAc-P-P-dolichol have been extended to show that enzymes in membrane preparations of hen oviduct catalyze synthesis of a Glc-containing oligosaccharide-lipid that is si... | 670,228 | [
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Thrombus formation in a staged capillary membrane oxygenator associated with a microaggregate blood filter: a scanning electron microscope study. | Blood contact at interfaces in extracorporeal devices is a source of traumas. Proteins are very rapidly adsorbed; then, depending on which proteins are left various degrees of platelet aggregation follow and thrombi develop. The scanning electron microscope reveals very instructive information on the morphology of the ... | 670,252 | [
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Hydraulic permeability of hollow-fiber membranes. | Two experimental methods have been developed to characterize the pressure-driven flow of a liquid through the walls of single hollow-fiber membranes. In one method, the permeation rate is measured directly by following the air-water interface in a pressurized pipet connected to a hollow fiber which is sealed at one end... | 670,261 | [
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Myelodysplasia. The influence of the quadriceps and hip abductor muscles on ambulatory function and stability of the hip. | In an analysis of motor function, ambulatory function, and hip stability in sixty-five patients with myelodysplasia, four motor-function groups based on the strength of the quadriceps and hip abductor muscles were identified. Retrospectively, it was evident that based on these groups, it would have been possible to pre... | 670,264 | [
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Function of the triceps surae during gait. Compensatory mechanisms for unilateral loss. | We studied the gait of a woman who was normal except for surgical excision of the gastrocnemius and soleus muscles. She was able to compensate for nearly all of her abnormalites of gait by excessive lateral pelvic tilt and prolonged quadriceps activity. Her mild disability, as regards gait, consisted of inability to in... | 670,268 | [
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Fractures of the femoral shaft treated surgically. Comparative results of early and delayed operative stabilization. | In a study of the results of operative reduction and internal stabilization of eighty-nine femoral fractures, operative reduction was performed within six days in fifty-four of the fractures and between seven and thirty days in thirty-five. Dual Eggers plates were used in sixty-three fractures; intramedullary nails, in... | 670,271 | [
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Fluid balance within the canine anterolateral compartment and its relationship to compartment syndromes. | Fluid homeostasis within muscle compartments is maintained by four pressures: capillary blood pressure, capillary blood oncotic pressure, tissue-fluid pressure, and tissue fluid oncotic pressure. As determined in the canine anterolateral compartment, capillary blood pressure is 25 +/- 3 millimeters of mercury; capillar... | 670,272 | [
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DNA replication in human lymphocytes during aging. | An analysis of the accuracy of protein and DNA synthesis in human lymphocytes with respect to aging has been carried out. The response of human peripheral lymphocytes, from young and old adults, to phytohemagglutinin was measured at varying temperatures. This should provide a sensitive test for the accumulation of alte... | 670,307 | [
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Lack of a correlation between polyamine synthesis and DNA synthesis by cultured rat liver cells and fibroblasts. | Growth stimulation of either fetal rat liver cells or rat embryo fibroblasts in culture results in considerable increases in intracellular polyamine levels as cells proceed through the cell cycle. Treatment of such cell cultures with appropriate levels of two inhibitors of polyamine synthesis, namely alpha-hydrazino or... | 670,309 | [
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A human serum protein system affecting muscle contractility: characterization of the five components and their reaction sequence. | A human serum protein system that affects muscle contractility, previously reported to be a calcium transport system (CTS), was fractionated into five protein components, A, B1, Bfi, B3 and C. The system was assayed on frog heart muscle in vitro by its capacity to increase contractile force and at high concentrations t... | 670,311 | [
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Diffusible factor(s) controlling density inhibition of 3T3 cell growth: a new approach. | In 3T3 Swiss mouse fibroblasts, incorporation of phosphate into cells and phosphorylation of small organic compounds were increased by shaking dense cultures. This response was not obtained with SV40 transformed Swiss 3T3 cells (SV-3T3). It appeared likely that these results could be accounted for by an inhibitor relea... | 670,314 | [
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Analysis of the penetrable space within the nucleus. | Radioactive glycogen molecules have been used as passive probes to compare cavity systems within nuclei and isolated chromatin. Isolated chromatin was found to possess a narrow range of microspaces with mean effective diameters between 4.0 and 4.5 nm (40 and 45 A) depending on shape assumptions. Intact nuclei contained... | 670,315 | [
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0.2813158,
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0.7293109,
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0.03493764,
... |
Survival of 125iodine-labeled Factor VIII in normals and patients with classic hemophilia. Observations on the heterogeneity of human Factor VIII. | Radiolabeled human Factor VIII was used to study its survival in normals and patients with classic hemophilia, and to study the heterogeneity of Factor VIII; Purified Factor VIII was radiolabeled with 125iodine (125I-VIII) without loss of its structural integrity. The survival of 125I-VIII was studied in six normals an... | 670,391 | [
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Glucose and alanine metabolism in children with maple syrup urine disease. | In vitro studies have suggested that catabolism of branched chain amino acids is linked with alanine and glutamine formed in, and released from, muscle. To explore this possibility in vivo, static and kinetic studies were performed in three patients with classical, and one patient with partial, branched chain alpha-ket... | 670,400 | [
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0.18304... |
Discrimination of speech intensity differences via vibrotactile stimulation. | This study investigated vibrotactile difference limen judgments for intensity using certain speech signals as stimuli. The variables under investigation were those of stimulus presentation level, direction of intensity increment or decrement within each paired-comparison stimulus complex, and the spectral composition o... | 670,434 | [
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Huddling by rat pups: multisensory control of contact behavior. | Huddling, or clumping behavior, begins in the litter situation and persists throughout the adult life of the rat (Rattus norvegicus). In pups, as in adults, the behavior provides a metabolically important means of reducing heat loss. The sensory stimuli that elicit, direct, and maintain huddling in developing rat pups ... | 670,451 | [
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Garter snake trailing behavior: effects of varying prey-extract concentration and mode of prey-extract presentation. | In a multiple-choice maze, garter snakes were trained to follow earthworm-extract trails for worm bit rewards. In Experiment 1, they were tested for their abilities fo follow extract trails that had been dried or extract trails that were removed from direct lingual access by a perforated floor. Snakes were able to foll... | 670,459 | [
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Hypertension and myocardial infarction. | In a representative series of male patients (n = 504) surviving the hospital stay of a first myocardial infarction the prevalence of hypertension and the influence of hypertension on the prognosis during 2 yr follow-up were studied. According to the definitions used hypertension had been detected before or was detected... | 670,536 | [
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Temporal integration of tone glides. | Temporal integration of rising and falling tone glides against a 50-2800-Hz background of noise at a sound pressure level of 60 dB re 20 micronPa was studied in two experiments. Glides were in the frequency ranges 200-700 Hz and 1200-1700 Hz for durations of 5-120 ms. Results indicate an asymmetry in the detectability ... | 670,544 | [
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Evidence for a general template in central optimal processing for pitch of complex tones. | Optimum processor theory successfully accounts for earlier pitch data by including the constraint that component tones in a complex stimulus are estimated as successive harmonics. This constraint gives the paradoxical prediction that a periodic complex tone comprising nonsuccessive harmonics cannot evoke periodicity pi... | 670,547 | [
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Auditory handicap of hearing impairment and the limited benefit of hearing aids. | The aim of this article is to promote a better understanding of hearing impairment as a communicative handicap, primarily in noisy environments, and to explain by means of a quantitative model the essentially limited applicability of hearing aids. After data on the prevalence of hearing impairment and of auditory handi... | 670,550 | [
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Activity level: a comparison between actometer scores and observer ratings. | Activity level of 13 boys (aged 9-13) from a day hospital program was measured using actometers in classroom, gym, woodshop, and group therapy settings. Ratings of Ss' activity were obtained from mothers using the Werry scale, and from six clinical staff familiar with the Ss using the Davids scale. It was predicted tha... | 670,584 | [
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The Peer Preference Test as a measure of reward value: item analysis, cross-validation, concurrent validation, and replication. | Thirty-six preschoolers were administered and retested on a 15-item Peer Preference Test designed to measure the reward value of peers for each child. Test-retest reliability was .88, and after item analyses, 12 items were maintained in the test. The revised test was then administered to 29 other preschoolers. Test-ret... | 670,585 | [
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0.08420318,
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Geriatrics program for medical students. II. Impact of two educational experiences on student attitudes. | In an innovative program in geriatrics for undergraduate medical students, the preliminary report concerned attitudes toward the aged among health care personnel. This follow-up report concerns the stability of, and changes in medical students' attitudes toward the aged after participation in one of the following types... | 670,623 | [
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Localization of carbohydrate components in rat colon with fluoresceinated lectins. | Cryostat sections of rat descending colon were studied by fluorescence microscopy after exposure to conjugates of fluorescein isothicoyanate with lectins from Glycine max (soybean), Triticum vulgaris (wheat germ), Ricinus communis (castor bean), Ulex europaeus, (gorse), Dolichos biflorus (horse gram) and Canavalia ensi... | 670,681 | [
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Cytophotometric analyses of myocardial RNA in rats exposed to altitude hypoxia. | Analytical cytophotometry of azure B-stained heart sections was employed to investigate the pattern of myocardial ribonucleic acid (RNA) alterations in rats exposed to acute (1-2 days) and prolonged periods (1-8 weeks) of hypoxia exposure (380 torr). Data support the existence of a slight transient drop in myocardial R... | 670,682 | [
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Polymorphism at the glucosephosphate isomerase locus in the dog. | A polymorphism of the enzyme glucosephosphate isomerase (GPI) in canine red blood cells is reported. This polymorphism was detected by horizontal starch gel electrophoresis utilizing a tris-EDTA-borate buffer system of pH 8.0. Four out of 92 dogs examined appeared to be heterozygous at this locus. | 670,678 | [
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Microsurgical cannulation of the thoracic duct in cats. Technical note. | The authors describe a new technique for the microsurgical cannulation of the thoracic duct. A small silastic tube is utilized which can be joined to a subcutaneously implanted one-way flow, CSF, Ommaya-type reservoir. Extended drainage is avoided. No deletion or alteration of major venous channels occurs. Lymph collec... | 670,719 | [
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Studies on the microcytotoxicity test. III. Comparison of [75Se]selenomethionine with [3H]proline, Na2, 51CrO4 and [125I]iododeoxyuridine for pre-labelling target cells in long-term cytotoxicity tests. | Four intracellular radioisotope labels, [3H]proline, Na2 51CrO4, [75Se]selenomethionine and [125I]iododeoxyuridine, were evaluated for use in a pre-labelling long-term microcytotoxicity assay for cell-mediated immunity. Adherent rat tumour cells established in tissue culture were used as targets and the basic variables... | 670,727 | [
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II. Ultrastructural differences in attachment patterns of indicator cells to target cells in the rosette-forming process. | A comparison was made of the electron microscopic appearances of rosettes formed between mouse spleen lymphocytes and indicator cells with the ligands exposed on their surfaces either in clusters or in continuity. Sheep red blood cells (SRBC) coated with protein A of Staphylococcus aureus or human IgG by the chromium c... | 670,732 | [
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Identification and characterization of mannosyl retinyl phosphate occurring in rat liver and intestine invivo. | A study was conducted to determine whether mannosyl retinyl phosphate occurred in rat liver and intestine in vivo, and, if so, to partially purify it and investigate its properties. After injection of [(3)H]retinol and [(14)C]mannose, a chloroform-methanol 2:1 extract of rat liver and small intestinal mucosa yielded tw... | 670,836 | [
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Ultrastructural observations on the chorionic epithelium, parathyroid glands and bones from chick embryos developed in shell-less culture. | Three-day-old chick embryos were cultured in Petri dishes until they reached developmental stages 37 or 39 (Hamburger & Hamilton, 1951). The electron microscopical study of the chorio-allantoic membranes showed that, even in the absence of the shell and the corresponding calcium supply, 'capillary-covering' and 'vi... | 670,857 | [
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Kinetics of sodium and lithium movements across the blood-brain barrier of an insect. | The electrical responses of axons were used to monitor the time-course of a change in the concentration of an ion species in the fluid bathing the axons in connectives of isolated cockroach nerve cords. Initial exposure of the connectives to sodium-deficient Ringer resulted in a depletion of extra-axonal sodium which w... | 670,872 | [
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Human C4-binding protein. I. Isolation and characterization. | C4-binding protein (C4-bp), a new component of the complement system, was isolated from human plasma by precipitation with polyethyleneglycol, followed by chromatography on ion exchangers. C4-bp was identified on sodium dodecyl- sulfate polyacrylamide gel electrophoresis (SDS-PAGE) by two independent criteria: its abil... | 670,886 | [
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The role of predrug signals in morphine analgesic tolerance: support for a Pavlovian conditioning model of tolerance. | According to a model of morphine tolerance, which emphasizes Pavlovian conditioning principles, tolerance results from an association between predrug environmental cues and the systemic effects of the drug. To assess this model, groups of rats were administered morphine on either three or nine occasions, with a complex... | 670,891 | [
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[Determination of serum iron; a comparison of two methods: atomic absorption and bathophenanthroline without deproteinisation (author's transl)]. | Two methods for the assay of serum iron are compared; determination by atomic absorption after deproteinisation, and spectrophotometric determination after liberation of the iron by a detergent, reduction with dithionite, and chelation with bathophenanthroline disulfonate, without deproteinisation. Regression: y = 0.99... | 670,898 | [
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Continuous tracking of behavioral development in infants. | Infant development scales provide a one time measure of the number of scale items an infant performs and his standing relative to his age group. Repeated assessment indicates how many more items he can perform and whether his relative status has altered but does not measure actual changes in the same behaviors as devel... | 670,954 | [
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Visual evoked responses and visual symptoms in multiple sclerosis. | Absolute latency, interocular difference in latency, and waveform of visual evoked responses (VER) to checkerboard reversal stimuli recorded from the midline of the skull were studied in 104 multiple sclerosis patients, 25 to 50 years of age, classified according to visual symptomatology. Group 1 had strong evidence of... | 671,060 | [
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Selective impairment of topographical memory: a single case study. | We describe a patient who developed topographical memory loss after a closed head injury. His symptoms and the psychological test results indicate a selective deficit of topographical memory, his perceptual and spatial skills being relatively unimpaired. | 671,070 | [
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Assessment of the effects of cinglulate gyrus lesions by neuropsychological techniques. | Nineteen psychiatric patients undergoing bilateral cryogenic cingulate cortex lesions were extensively evaluated pre- and postoperatively with objective measures of intelligence, higher cortical functions, memory, and emotional status. Following surgery the patients as a group revealed no significant deterioration of f... | 671,079 | [
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Changes in organ growth with feeding pattern. The influence of feeding frequency on the circadian rhythm of protein synthesis in the rat. | The effect of eating one large meal rather than several small meals per day on protein metabolism and the growth of individual organs was investigated in young male rats. Meal-eating did not affect the rate of protein catabolism in liver, kidney, small intestine, or spleen in vivo compared with continously fed control ... | 671,094 | [
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The influence of zinc-deprivation on the mast cell population of the bone marrow and other tissues. | Five groups consisting of 72 young male Sprague-Dawley rats were submitted to dietary Zn deprivation (1 ppm versus 50 ppm for controls) for periods of 1 to 6 weeks with ad libitum or pair feeding. After 1 week of Zn deficiency, growth was almost arrested, the oesophageal epithelium became hyperplastic. After 3 weeks, t... | 671,099 | [
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Effect of nicotinic acid on catecholamine synthesis in rat brain. | Effect of nicotinic acid on the formation of catecholamine has been studied. Norepinephrine and dopamine concentrations in brain were 30 per cent higher and brain catecholamine formation was 50 per cent higher in the nicotinic acid-supplemented rats than the nicotinic acid-deficient rats. However, these catecholamine l... | 671,109 | [
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Mortality of female workers in rubber manufacturing plant. | The ten-year mortality experience of a cohort of white female production workers in a large rubber manufacturing plant is presented. An analysis of the observed and expected numbers of death from numerous causes revealed a slightly elevated overall standarized mortality ratio with an excess of deaths from both lung can... | 671,118 | [
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Mesothelioma in the United States. Incidence in the 1970's. | Mesothelioma is a rare neoplasm, the occurrence of which has been clearly related to asbestos exposure. Data recently collected by population based cancer registries in Washington, Hawaii, New Mexico, Connecticut, Michigan, Utah, Louisiana and Iowa were obtained for the determination of mesothelioma incidence rates. Th... | 671,123 | [
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Geographic patterns of industry in the United States. An aid to the study of occupational disease. | The geographic location of 18 major manufacturing industries within the United States is illustrated by a series of computer-generated county maps. The metal and machinery industries, the two largest employers, an the transportation and rubber industries are concentrated in the northeastern quadrant of the United State... | 671,124 | [
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A visual system model and a new distortion measure in the context of image processing. | Underlying many techniques of image restortation, quantization, and enhancement is the mathematically convenient, but visually unsuitable distortion measure of squared difference in intensity. Squared-intensity differences has an indirect phenomenological correspondence in a model of the visual system. We have undertak... | 671,131 | [
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Laser Doppler measurements of blood velocity in human retinal vessels. | We have measured Doppler shift frequency spectra (DSFS) of laser light scattered from red blood cells (RBC's) flowing through individual human retinal vessels. Each spectrum exhibits a cutoff frequency which is directly related to the maximum RBC velocity at the measurement site. Meaningful DSFS can be measured in time... | 671,138 | [
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Thiamine-responsive megaloblastic anemia, sensorineural deafness, and diabetes mellitus: A new syndrome? | A 6-year-old girl is described who has congenital megaloblastic anemia which completely responded only to pharmacologic doses of thiamine. Relapse was observed twice when the drug was discontinued. The reintroduction of thiamine caused a prompt reticulocytosis and a rise in hemoglobin concentration. Other abnormalities... | 671,156 | [
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The properties of surround antagonism elicited by spinning windmill patterns in the mudpuppy retina. | 1. A truncated spinning windmill pattern, illuminating only the receptive field surround, shown previously to activate amacrine cells, was used to elicit activity at the inner plexiform layer and to reduce the response of ganglion cells to test flashes at the receptive field centre. 2. The spinning windmill pattern re... | 671,274 | [
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Influence of intermittent breathing on ventricular depolarization patterns in chelonian reptiles. | 1. Alterations between two quite distinct patterns of epicardial depolarization are associated with the normal occurrence of intermittent lung ventilation in both lightly anaesthetized and unrestrained, conscious turtles (Pseudemys scripta) and tortoises (Testudo graeca). 2. During apnoea depolarization sweeps from the... | 671,311 | [
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A transient release of potassium mediated by the action of substance P on rat parotid slices. | Substance P (a peptide of eleven amino acids) caused a Ca-dependent release of K+ from rat parotid slices. The response to substance P differed from the alpha-adrenergic and the cholinergic responses in that it was transient, of smaller extent, and was not inhibited by phentolamine and atropine. Substance P caused litt... | 671,331 | [
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Conductance increases produced by glycine and gamma-aminobutyric acid in lamprey interneurones. | 1. Conductances of individual neurones in the isolated lamprey spinal cord were measured with separate intracellular electrodes for recording potentials and for passing current pulses during application of glycine or GABA (0.1-1.0 MM) in Ca-free bathing fluid. Large, reversible increases in conductance were produced in... | 671,350 | [
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Aroyl- and arylisoquinolineacetic acids as antiinflammatory agents. | A series of 1-benzoyl- and 1-phenylisoquinolineacetic acid derivatives was prepared and tested for antiinflammatory activity. The most potent compound synthesized, 1-(4-chlorophenyl)-3-isoquinolineacetamide, was as active as phenylbutazone in the Evans blue carrageenan-induced pleural effusion assay but inactive in the... | 671,456 | [
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Nonsteroidal antiinflammatory agents. 2. Derivatives/analogues of dibenz[b,e]oxepin-3-acetic acid. | 6,11-Dhydro-11-oxodibenz[b,e]oxepins and some related compounds have been synthesized and evaluated for antiinflammatory effect according to the carrageenan paw edema method in rats. The structure-activity relationships have been discussed among acetic acid, carboxylic acid, alcohol, and tetrazole derivatives of dibenz... | 671,462 | [
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Anionic polymers and biological activities. Effects of some new polycarboxylic acids on the ascitic sarcoma 180 in mice. | Eleven new polymeric carboxylic acids with widely different solubilities in water have been synthesized. The activities of these polymers against the ascitic sarcoma 180 tumor of mice and their acute toxicities in mice have been compared with molecular parameters of the polymers such as molecular weights, charge densit... | 671,463 | [
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Political neutrality and international cooperation in medicine. | International cooperation is an integral part of furthering medical and scientific progress. Many specilist societies exist for that purpose and have written into their constitutions that such cooperation and coordination is their aim. They hope to achieve their aims by exchange, in all languages, of information and by... | 671,475 | [
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Inconsistent expression of both centromeres of a dicentric Y chromosome in a child with ambiguous external genitalia. | A newborn child with ambiguous external genitalia had evidence of internal female development on the left and internal male development on the right. Blood chromosome analysis showed three cell types: 45,X; 46,XY with the Y being submetacentric and about twice the usual size with two 'centromeric' C bands; and 46,X,dic... | 671,491 | [
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Energy-dependence of phlorizin binding to isolated renal microvillus membranes. Evidence concerning the mechanism of coupling between the electrochemical Na+ gradient the sugar transport. | In order to elucidate the mechanism by which the electrochemical Na+ gradient energizes glucose transport, the energy-dependence of high affinity phlorizin binding to isolated renal microvillus membrane vesicles was examined. Phlorizin is a competitive inhibitor of glucose transport but is not itself transported. Extra... | 671,529 | [
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The morphology of the mucous gland and its responses to prolactin in the skin of the red-spotted newt. | The mucous gland of the red-spotted newt, Notophthalamus viridescens viridescens, Rafinesque was examined by histochemical and ultrastructural techniques and its cytological responses to various hormonal conditions were studied. Its secretory epithelial cells produce and release in merocrine fashion a neutral, unsulpha... | 671,558 | [
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Analysis of treatment problems in subtraochanteric fractures of the femur. | In a retrospective study of 82 subtrochanteric fractures of the femur in the St. Paul-Ramsey Hospital, there were 32 treated by traction, 50 by open reduction and internal fixation. In adults 50% of those treated by traction had undesirable results using strict criteria for varus, shortening, and rotational deformity: ... | 671,570 | [
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Cervical fractures and fracture-dislocations sustained without head impact. | Because of its flexibility and structure, the cervical spine is disposed to various mechanisms of injury: although not so common as injuries caused by head impacts, cervical fractures and/or fracture-dislocations have been reported without direct impact to the head. Some cervical injuries reported have been sustained b... | 671,572 | [
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Soluble endoribonuclease activity from vaccinia virus: specific cleavage of virion-associated high-molecular-weight RNA. | A soluble endoribonuclease activity was extracted from purified vaccinia virus cores by treatment with sodium-deoxycholate and dithiothreitol. The soluble enzyme readily cleaved purified virion-associated high-molecular-weight RNA to limit-sized fragments sedimenting at 8 to 12S. Purified virion-released 8 to 12S polya... | 671,588 | [
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Renal vein renin concentration in the hypertension of unilateral reflux nephropathy. | Hypertension is a frequent complication of reflux nephropathy. The cause of this hypertension is unknown. Our study was undertaken to assess the possible role of the renin-angiotensin system in the hypertension associated with unilateral reflux nephropathy. We selected for study 17 normotensive and 12 hypertensive pati... | 671,598 | [
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Nitrosamine formation in bladder infections and its role in the etiology of bladder cancer. | Dimethylnitrosamine, a powerful carcinogen, is produced in the urine of patients with urinary tract infections of Proteus mirabilis and Escherichia coli when nitrite is present. Treatment with tetracycline antibiotics does not enhance the concentration of this carcinogen but, rather, sharply reduces it. The results emp... | 671,604 | [
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Studies in inhibitors of calcification and levels of urine saturation with calcium salts in recurrent stone patients. | Studies have been done on patients with recurrent renal calculous disease, measuring in addition to the usual serum and urine constituents the inhibiting capacity of the urine and the activity products of calcium oxalate, octocalcium phosphate and brushite. Studies on the 24-hour urine calcium, phosphorus and uric acid... | 671,607 | [
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... |
Experience with measurement of bladder electrical activity. | A series of patients is presented in whom the recording of bladder electrical activity was performed. There was a significant difference in frequency of the spike activity between patients with upper and lower motor neuron injury. This technique would seem to offer greater clinical application in areas of bladder dysfu... | 671,615 | [
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-0.07930049,
0.3210849,
-0.3210834,
0.2507755,
0.1986417,
0.03994564,
0.2446... |
Urine cytology findings in analgesic nephropathy. | Urine cytology screening for neoplasm led to the detection of 3 urothelial carcinomas and 1 severe urothelial dysplasia in 98 patients with analgesic-induced papillary necrosis. A further 18 patients had changes suggesting that they were at risk of incurring malignancy in the near future. Routine urine cytology is reco... | 671,620 | [
-0.1080453,
0.04228558,
-0.1988574,
-0.174466,
0.1143432,
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0.001159513,
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0.03335065,
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0.3114208,
0.3966457,
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0.2523144,
0.09768789,
-0.209111,
0.... |
Split cuff ileal stoma. | Long-term patient comfort after an ileal conduit urinary diversion depends on the conduit stoma. The problem of leak-proof urine collection of the flush stoma can be overcome by using a spout stoma but this could become stenotic unless everted. Eversion is a technically difficult procedure and produces a bulky spout th... | 671,622 | [
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-0.4339386,
0.03696364,
-0.1077118,
-0.1018005... |
Experiences with colocystoplasties, cecocystoplasties and ileocystoplasties in urologic surgery: 40 patients. | During the last 16 years (1960 to 1976) we have treated 78 patients with a contracted bladder syndrome, 40 of whom have been treated surgically by replacing part or all of the bladder with an isolated segment of rectosigmoid, cecum or ileum. The series is a combination of 30 patients treated by Shirley in the United St... | 671,623 | [
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0.05740908,
0.05605067,
0.2158641,
0.2285582,
0.2286236,
... |
Evaluation of psychogenic urinary retention. | Urinary retention may develop in the absence of significant organic disease. Patients with psychogenic retention range from those with episodic acute retention to those who have learned to inhibit urination and have retention with a large residual urine volume owing to myotonic detrusor degeneration. A combination of t... | 671,632 | [
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Diagnosis and management of hydrometrocolpos in infancy. | Three cases of hydrometrocolpos in infants are presented, which demonstrate that despite thorough documentation of the clinical findings, the misdiagnosis and the ensuing mismanagement of this condition remain a problem. The presence of other genitourinary abnormalities and the association with anomalies of the anorect... | 671,652 | [
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0.05532977,
-0.1066258,
0.0... |
Rifampin therapy of Staphylococcus epidermidis. Use in infections from indwelling artificial devices. | Rifampin was added to existing antibiotic regimens in two patients with Staphylococcus epidermidis infections; one patient had prosthetic valve endocarditis and the other had an infection of a CSF shunt. The addition of rifampin increased serum or CSF bactericidal titers 16-fold or greater and was correlated with a fav... | 671,704 | [
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0.01154008,
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0.2519382,
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-0.1271291,
0.4296835,
-0.0... |
Comparison of the pharmacological effects of epinephrine administered by the intravenous and endotracheal routes. | Epinephrine in various dosages was administered to anesthetized dogs by intravenous and endotracheal routes. Both methods produced measurable effects on heart rate, blood pressure, and respiration. Tachycardia occurred more rapidly after endotracheal administration than after intravenous administration. Respiration app... | 671,937 | [
-0.4256234,
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0.06332675,
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0.03383834,
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0.1625004,
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0.1185745,
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0.04905725,
0.2423... |
A rubber band powered, piston-valve aspirator. | A new valved surgical aspirator is described which overcomes the shortcomings of conventional, valve-less suction devices. The valve piston which controls the flow of fluid is retained in the valve body by an ordinary rubber band. When the valve is opened by depressing the piston, the rubber band is stretched. When the... | 671,945 | [
-0.3172382,
0.2654637,
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0.08077727,
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0.1749518,
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0.1524521,
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0.1251404,
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-0.2328008,
0.00408109,
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-0.0379637,
0.1424182,
0.0863002... |
[Prevention of ventricular fibrillation in animal experiments]. | The precursors of ventricular fibrillation and asystole developing after ligation of a branch of the coronary artery and adrenalin injection were studied in 30 albino rats. The comparative efficacy of antiarrhythmic agents (ajmalin, lidocaine, isoptin, visken) in the prevention of ventricular fibrillation induced by el... | 671,971 | [
-0.06835476,
0.09952894,
-0.5051969,
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0.1497481,
0.2123923,
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0.1179976,
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0.2161329,
0.1269332,
0.1349694,
0.1962509,
-0.06465837,
-0.0210886,
-0... |
[Disorder of erythrocyte membrane calcium binding in hypertension and experimental genetic hypertension]. | Under conditions of physiological concentration of free calcium in the incubation medium (Ca2+f = 1.5 mM), the outer surface of the membrane of human and Wistar rat erythrocytes binds 435 +/- and 359 +/- 32 nmol calcium per 1 ml cells, respectively. The external surface of erythrocytes in patients with essential hypert... | 672,004 | [
-0.2463901,
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-0.07013141,
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0.1710708,
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0.2543052,
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0.2491781,
0.5091596,
0.1151677,
-0.2059972,... |
[Dynamic observation data on the course of ischemic heart disease]. | The clinical course of ischemic heart disease was followed-up for 3 to 5 years after coronarography in 91 patients with atherosclerotic affection of the coronary arteries who had not been given purposeful treatment. In 30.8 per cent in cases the clinical picture of the disease grew worse: angina of effort became more f... | 672,022 | [
-0.02170584,
0.1388828,
-0.2927629,
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0.01496928,
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-0.2870571,
0.2612081,
0.2287084,
0.3786925,
0.6335299,
0.2137817,
-0.08603752... |
[Alport's syndrome (author's transl)]. | A case report is given of a 22-years old student (whose brother had Alport's syndrome) with recurrent central corneal swelling and paracentral erosions of the cornea of both eyes. Further signs of beginning Alport's syndrome in this case are disturbance of re-adaptation after dazzling (Mesoptometer) and paracentral sco... | 672,101 | [
-0.05656598,
-0.2836294,
-0.01387762,
-0.08341452,
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-0.3074632,
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0.3500112,
0.2325849,
0.2328625,
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0.02588127,
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0.008213574,
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-0.07132265,
0.1432437,
-0.2288992,
-0.14152... |
[Levator strenght measurements. Oculomyodynamometry of the levator palpebrae superioris (author's transl)]. | The author describes a method of levator strength measurement with the oculomyodynamometer with which he measured a maximum strength of the levator muscle in adults of 58 G. The levators were much weaker in congenital ptosis. In three such cases the levators had strengths of only 9 G, 5 G and 5 G. In cases of acquired ... | 672,103 | [
-0.2027081,
-0.2076323,
-0.1757125,
-0.2339481,
0.1713507,
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0.01961884,
0.05499861,
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0.1266197,
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0.01341842,
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0.418536,
0.3660947,
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-0.09484739,
... |
[Possible influence of plasma factors on lymphocyte blastigenesis and E rosette forming in rheumatoid arthritis (author's transl)]. | The lymphocytes blastigenesis to PHA in culture with autologous or normal plasma, the formation of E rosettes and the presence of immunoglob-lins on the lymphocytes surface were evaluated in 51 patients with chronic primary polyarthritis. While the percentage of T and B cells was almost normal (52.1 +/- 2.1% and 18.1 +... | 672,138 | [
0.04172691,
-0.2044568,
0.1193153,
0.009022215,
0.0963791,
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0.09698153,
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0.1837192,
0.04812915,
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0.07675883,
0.2208453,
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0.009160006,
0.4153621,
0.500143,
0.1903433,
-0.1610249,
... |
Performance of the African giant rat (Cricetomys gambianus Waterhouse) on commercial rations and varying dietary protein levels. | The growth performance of 24 weanling giant rats was studied in 2 experiments of 30 weeks duration with commercial livestock rations and graded levels of protein. Daily average liveweight gain was 5.1-7.3 g, food consumption 26.9-36.3 g on 6 diets. Food intake, growth rate and food efficiency ratio were very similar us... | 672,175 | [
0.1700834,
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-0.286009,
0.1891407,
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0.145753,
-0.0535216,
0.06373395,
0.4572776,
-0.1237443,... |
Experimental breeding and cytogenetics of the soft-furred rat, Millardia meltada. | The soft-furred rat, Millardia meltada, has bred successfully in the laboratory for 10 generations of brother x sister mating. It is half way in size between the rat and the mouse, and is gentle and easy to handle. Thin body hair and incisor teeth are present in the newborn. Some individuals have low blood pressure. Ch... | 672,179 | [
-0.1297266,
0.1057684,
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0.01539857,
0.02806909,
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0.4657179,
0.01185108,
-0.1531654,
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Histochemical study of mesenteric lymph nodes in old rats. | The main positive reactions in the large mononuclear cell occurring in some nodes were shown with PAS, alcian blue, Sudan black B and acid haematin. The results suggest that in these cells, considered to be mononuclear phagocytes, there is a storage of hexose-containing mucosubstances, acid mucopolysaccharides and chol... | 672,184 | [
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0.1081742,
0.2930638,
0.1826391,
0.04057555,
0.06054877,
-0... |
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