title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Analysis of spermidine and spermine in rat liver. Effect of hypophysectomy on polyamine concentrations. | A simple, rapid, reproducible assay for tissue polyamines using a standard unmodified amino-acid analyzer is described. This technique will allow accurate measurement of the polyamines from as little as 10 mg of liver in less than 1 h. We have used this method to establish the optimum conditions for the extraction of p... | 667,682 | [
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Effect of the basic amino-acid side chain length and the penultimate residue on the hydrolysis of benzoldipeptides by carboxypeptidase B. | The kinetic parameters Km and k cat/K m have been determined for the carboxypeptidase B (CPB, EC 3.4.12.3) catalyzed hydrolysis of benzoylglycyl-DL-homolysine and benzoylglycyl-L-homorginine. Plots of these data and those for Bz-Gly-Orn and Bz-Gly-Arg (Wolff, E. C., Schirmer, E.W. & Folk, J. E. (1962) J. Biol. Chem... | 667,683 | [
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Cytosol protein-independent translocation of isomeric spin-labelled radioactive lipids from isolated guinea pig liver microsomal to mitochondrial membranes. | Intermembranous translocation of membrane-bound radioactive lipids covalently labelled with 5-, 12, and 16-doxyl stearic acid was studied. Guinea pig liver microsomal membranes containing known amounts of isomeric spin-labelled radioactive phosphatidic acid, phosphatidylcholine, and diglycerides were incubated with unl... | 667,689 | [
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Electrogenic sodium-dependent glycine transport in sheep reticulocytes. | Na+-dependent glycine transport has been studied in reticulocyte-enriched fractions of blood obtained after massive bleeding of sheep. The activity is dependent on the sodium electrochemical potential and the membrane potential. The sodium chemical gradient was varied by changing either external or internal Na+ and the... | 667,699 | [
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The effect of taurine on kindled seizures in the rat. | Recently, it has been reported that taurine, an amino acid with anticonvulsant properties, does not suppress experimental seizures generated by the "kindling" technique. This finding seems somewhat paradoxical since taurine antagonizes other sorts of experimental convulsion and since kindled seizures are easily suppres... | 667,725 | [
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Flow correlation of loop of Henle potassium influx. | Potassium influx in short loops of Henle was assessed using end proximal to early distal perfusion with potassium-free saline. Over a wide range of perfusion rates influx was highly correlated with collected flow rates. The magnitude of the influx was comparable with the delivery rate of potassium to the early distal s... | 667,732 | [
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Halobacterium vallismortis sp. nov. An amylolytic and carbohydrate-metabolizing, extremely halophilic bacterium. | The extremely halophilic bacterium (formerly designated as strain J.F. 54) isolated from salt pools of the Death Valley, California, is a motile, Gram-negative, extremely pleomorphic organism, aerobe, and facultative anaerobe. A variety of carbohydrates are assimilated with or without acid production; soluble starch is... | 667,737 | [
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[Ultrastructural study of the biodegradation processes. I. Beech (Fagus sylvaticus L.) leaf white rot]. | An electron microscopic study of beech leaf white rot shows a certain number of characteristic developmental stages which are identical whether the material is from in vitro experimentation or from natural incubation. Endowed with a cellulolytic properly seemingly localized in the apical region only, hyphae of the whit... | 667,739 | [
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Diet in the management of hyperkinesis: a review of the tests of Feingold's hypotheses. | Through the 1970s, Benjamin Feingold has published a series of studies in which he claimed that a diet free of salicylates, artificial food flavours and colours results in a remission of symptoms in 30 to 50 percent of children diagnosed as hyperactive. Parents of hyperactive children have responded strongly to the hyp... | 667,782 | [
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Pituitary fibrosarcoma secondary to radiation therapy. | A patient who received postoperative radiation therapy for the treatment of a chromophobe adenoma developed a fibrosarcoma of the pituitary gland region 10 years later. A single course of irradiation was given with a total dose to the pituitary of 4092 rad in 21 fractions and 29 days using Cobalt 60 radiation at a sour... | 667,787 | [
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Incidence of meningeal involvement by rhabdomyosarcoma of the head and neck in children: a report of the Intergroup Rhabdomyosarcoma Study (IRS). | 141 patients with embryonal rhabdomyosarcoma (RMS) of the head and neck are reviewed. 57/141 had lesions of para-meningeal sites. 20/57 (35%) developed evidence of direct meningeal extension. 18/20 (90%) died of this complication. Radiation portals and doses were limited in 42% and 32%, respectively. All patients had c... | 667,796 | [
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Extraskeletal Ewing's sarcoma: a preliminary review of 26 cases encountered in the Intergroup Rhabdomyosarcoma Study. | Twenty-six of three hundred and fourteen (26/314) patients whose tumors were reviewed by the Pathology Evaluation Committee of the Intergroup Rhabdomyosarcoma Study have histologic subtypes I and II which have morphologic characteristics similar to Ewing's sarcoma of bone. They are somewhat more common in an extremity ... | 667,797 | [
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Steroid receptor analyses of nine human breast cancer cell lines. | Nine human breast cancer cell lines in permanent tissue culture and currently available to researchers have been assayed for their content of cytoplasmic estrogen receptors, progesterone receptors, androgen receptors, and glucocorticoid receptors, as well as for the presence of unfilled or hormone-filled nuclear estrog... | 667,841 | [
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Photoradiation therapy for the treatment of malignant tumors. | Administration of hematoporphyrin derivative i.v. followed by local exposure to red light has resulted in complete or partial response in 111 of 113 cutaneous or s.c. malignant lesions. Tumors treated have included carcinomas of the breast, colon, prostate, squamous cell, basal cell, and endometrium; malignant melanoma... | 667,856 | [
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Angiographic anatomy of the left Kugel's artery. | The left Kugel's artery is an uncommon but sometimes important collateral between the proximal circumflex artery and whatever artery supplies the crux of the heart. It passes anterior to the mitral valve ring, coursing in the interatrial septum, to anastomose usually with the atrioventricular node artery. The left Kuge... | 667,917 | [
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Submitral annular left ventricular aneurysm--unusual echocardiographic and angiographic features. | A submitral annular left ventricular aneurysm in a Nigerian patient is described. The features consisted of an abnormal bulge on the left heart border with curvilinear calcification, an echo-free space behind the posterior left ventricular wall, and unusual angiographic appearance of the left circumflex coronary artery... | 667,919 | [
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The replication of kinetoplast DNA networks in Crithidia fasciculata. | Kinetoplast DNA from the mitochondria of Crithidia is in the form of a two-dimensional network of thousands of minicircles each containing about 2.5 kb, and a small number of maxicircles each containing about 40 kb. Fractionation of kinetoplast DNA by equilibrium centrifugation in a CsCl-propidium diiodide gradient res... | 667,931 | [
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Length and sequence heterogeneity of the histone gene repeat unit of the sea urchin, S. purpuratus. | Histone gene repeats in S. purpuratus are shown to be of variable length and sequence. Two recombinant plasmids containing the full-length 6.3 kb histone repeat unit are found to differer in length at two sites in the repeating structure and in the occurrence of two restriction enzyme recognition sites. Variation in re... | 667,939 | [
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Isolation and characterization of amphotericin B-resistant cell lines in Chinese hamster cells. | Amphotericin B is a polyene macrolide antibiotic which interacts specifically with sterols in mammalian cell membranes. Amphotericin B-resistant (AMBr) lines of stable phenotype have been isolated from cultured Chinese hamster (V79) cells. Three AMBr clones (AMBr-1, -2 and -3) isolated independently after treatment wit... | 667,948 | [
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Sterol synthesis. Chemical synthesis, structure determination and metabolism of 14 alpha-methyl-5 alpha-cholest-7-en-3 beta, 15 beta-diol and 14 alpha-methyl-5 alpha-cholest-7-en-3 beta, 15 alpha-diol. | 14alpha-Methyl-5alpha-cholest-7-en-3beta,15beta-diol and 14alpha-methyl-5alpha-cholest-7-en-3beta,15alpha-diol have been prepared by chemical synthesis. Unequivocal establishment of these structures was based upon X-ray crystallographic analysis of 3beta-p-bromobenzoyloxy-14alpha-methyl-5alpha-cholest-7-en-15beta-ol an... | 668,029 | [
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A micromethod for separation and identification of digestive enzymes in brush border membrane fragments of single human intestinal biopsies. | A micromethod for the isolation of brush border membrane fragments from single peroral duodenal biopsies, and their subsequent analysis by polyacrylamide gel electrophoresis is described. The quantity of biopsy material used varied between 5 and 15 mg wet weight, leaving enough mucosa for histological examination. By c... | 668,114 | [
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Radioimmunoassay of digoxin employing charcoal entrapped in magnetic polyacrylamide particles. | Charcoal and magnetisable ferric oxide were entrapped in a polyacrylamide gel and, after lyophilisation and micronisation, empolyed for the uptake of free antigen in a radioimmunoassay for digoxin. The results obtained were similar to those using a conventional charcoal separation method. | 668,127 | [
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Antisecretory and antiulcer properties of prostaglandins. | Certain prostaglandins inhibit gastric secretion and exert an antiulcer activity. These properties, first discovered in animals, were confirmed in humans and are likely to be useful in the treatment of peptic ulcer. On the other hand, several prostaglandins given at high doses favor the passage of water and electrolyte... | 668,288 | [
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Contact urticaria provoked by balsam of Peru. | Six patients with chronic urticaria are described in whom immediate type hypersensitivity to balsam of Peru was proven by patch test. | 668,338 | [
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Simple methods for demonstration of epoxy resins of bisphenol A type. | Low molecular weight oligomers of epoxy resins of bisphenol A type are common sensitizers. For demonstrating the presence of sensitizing oligomers of these resins, two simple methods are described. The first one, a colour reaction, demonstrates the presence of the bisphenol A skeleton. If this test is positive, thin-la... | 668,339 | [
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Nephropathies due to analgesics. | Analgesic drugs causing kidney functional disturbances and histologically evident kidney derangements are reviewed. Today, not the pathological changes, which have dominated the scene of pathogenesis for analgesic nephropathies are in the foreground of investigative interest, but rather the biochemical interactions of ... | 668,381 | [
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Aggravating factor in lupus nephritis; electron microscopic observation. | 47 renal biopsies from 36 patients with SLE were examined in detail to compare with clinical courses and ultrastructural findings. Of 36 patients, 8 cases were free from renal involvement. The severity of electron dense deposits in glomeruli with lupus nephritis were generally well correlated with each clinical feature... | 668,383 | [
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The correlation of antibodies to nuclear ribonucleoprotein (RNP) and nuclear acidic protein (Sm) with nephritis in patients with systemic lupus erythematosus (SLE). | The role of antibodies to Sm and RNP in renal diseases in SLE was investigated using counter immunoelectrophoresis (CIE). Antibody to RNP was found in about 50% of lupus patients irrespective of the degree of renal involvement as evaluated clinically, histologically and immunopathologically. Antibody to Sm was found mo... | 668,385 | [
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-0.3692226,
0.1902616,
0.07546065,
0.02945074,
0.001099658,
0.4317604,
0.1930213,
-0.06329009,
-0.333554,
-0.1138959,
-0.1404556,
-0.1489544,
0.3745218,
0.3343333,
0.196656,
-0.01304314,
-0.5079054,
-... |
Rabies and cerebrospinal nematodosis in woodchucks (Marmota monax) from New York. | Abnormal behavior, suggestive of rabies, is not an unusual finding in woodchucks (Marmota monax). Necropsy records, rabies antibody tests, and necropsy examinations performed by the authors indicate that migration of ascarid larvae usually is responsible for the abnormal behavior, and that rabies is an infrequent findi... | 668,397 | [
-0.04599182,
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0.150571,
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0.04325908,
0.08980818,
0.01759967... |
Porphyria cutanea tarda: response to vitamin E. A review and two case reports. | Porphyria cutanea tarda is a disease characterized by a triad of cutaneous manifestations: "fragile" skin, usually involving the dorsal aspects of the hands, forearms, legs, or feet; mild hyperpigmentation; and hypertrichosis, especially of the face. The condition is due to a metabolic defect of liver function involvin... | 668,411 | [
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0.3800635,
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0.04793442,
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0.1147804,
0.06213033,
0.107587,
-0.007393062,
-0.1648688,... |
Physiologic effects of the position of the body in experimental unilateral emphysema. | The functional residual capacity (FRC), static compliance (Cst) of the respiratory system, minute ventilation, and arterial blood gas levels were studied in the prone, the suprine, and the right and left lateral decubitus positions in dogs with papain-induced emphysema of the right lung alone and were compared with con... | 668,439 | [
0.2602017,
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0.1160839,
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0.01374893,
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-0.5704951,
0.09561343,
-0.09526512,
-0... |
Corticosteroids in radiation-induced pericarditis. | We describe a patient who developed acute pericarditis with effusion six weeks following irradiation of the chest for bilateral carcinoma of the breast. Oral therapy with corticosteroids was rapidly followed by a decrease of the cardiac shadow and by clinical improvement; the pericardial fluid did not reappear during a... | 668,445 | [
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-0.002495163,
0.177573,
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-0.02097599,
0.1175036,
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-0.1475772,
-0.1376569,
0.5020933,
0.09969909,
-0.0... |
Phenotypic variations in gentamicin-resistant isolates of Staphylococcus aureus. | Eight clinical isolates of Staphylococcus aureus showing high level resistance to seven aminoglycosides are described. The resistance did not appear to be due to enzyme inactivation. Possible mechanisms of this resistance are discussed. Resistant strains showed phenotypic variations in the form of different colonial mo... | 668,448 | [
0.1199892,
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0.1050764,
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0.3984191,
0.2787261,
0.05772899,
0.1856737,
... |
[Haemodynamic effects of nefopam (author's transl)]. | The haemodynamic effects of nefopam (0.3 mg/kg i.v.) were measured for 45 minutes in ten patients with coronary heart disease. The drug is a new and highly potent analgesic without any respiratory depressant effect. Arterial blood pressure and cardiac output rose moderately, while left ventricular enddiastolic pressure... | 668,511 | [
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0.1924337,
0.2060427,
0.3043405,
-0.02990988,
-0.04773869,
-0.101... |
[Echovirus 30 epidemic (author's transl)]. | Echovirus 30 was the cause of abacterial meningitis and pharyngitis in 22 cases in the Ludwigshafen on Rhine area in summer 1976 and in a further 26 cases in various regions of the German Federal Republic. In 11 children echotype-30-virus could be isolated from the CSF. In 47 children the diagnosis was established by a... | 668,544 | [
-0.1602007,
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-0.2528887,
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-0.1586636,
0.2450092,
0.3098983,
0.1929442,
0.2379366,
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0.3660808,
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0.3540145,
0.3806064,
-0.00713765,
-0.1257422,
... |
[The effect of progesterone uterine therapeutic system on dysmenorrhoea: prostaglandin F2alpha levels in menstrual blood (author's transl)]. | The menstrual flow of five dysmenorrhoeic women was collected, four cycles with and two cycles without local intrauterine administration of progesterone (Progestasert). The menstrual flow of three eumenorrhoeic women served as control. Menstrual blood was collected by tampons stored in butyl-alcohol saturated with wate... | 668,582 | [
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0.003910747,
0.1069022,
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0.04916589,
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0.1050608,
0.135953,
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0.2823909,
0.3635563,
0.1083834,
-0.231048... |
Inhibin-like effects of interstitial testis fluid: effects on serum FSH and androgen-binding protein in epididymis. | Application of rat interstitial testis fluid (ITF) to orchidectomized rats diminishes significantly the rise of FSH in serum following castration. The effect is seen for 12-24 hours on day 3 and 50 after orchidectomy but not at 48 hours in rats treated 50 days after orchidectomy. LH levels are not significantly affecte... | 668,636 | [
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0.1092303,
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0.157877,
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0.03631464,
0.1771079,
0.05088912,
0.0956384,
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0.02005291,
0.07319427,
0.1757863,
-0.08347899,
0.07236201,
-0.1249255,
-... |
CNS--endocrine pancreas system. III. Further studies on the vagal responsiveness to insulin deficiency. | Distribution and activity of acetylcholinesterase (AChE) in the neurons of the central vagal nuclei at the level of the medulla oblongata were studied in intact and alloxan-diabetic adult male rats by Gomori's histochemical method. Peculiarities of intracellular distribution of the enzyme in the Nucl. dorsalis n. vagi ... | 668,640 | [
0.6139439,
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0.1766236,
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0.3730231,
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-0.1370087,
0.532216,
0.09698419,
0.1464881,
0.13485... |
Differences in cardio-respiratory responses to exhaustive exercise between athletes and non-athletes. | To study the factors limiting the O2 supply in heavy exercise, O2 uptake at exhaustion was determined by progressive loading method with a bicycle ergometer in 33 well-trained male runners and 34 male sedentary adults. Pulmonary ventilation, oxygen removal, respiratory rate, tidal volume, pulmonary diffusing capacity, ... | 668,678 | [
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0.5434564,
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0.2374161,
0.00006355951,
0.03250502,
-0.1198023,
0.1728873,
0.113826... |
Total and alactic oxygen debts after supramaximal work. | The total and alactic oxygen debts were measured in eight subjects following supramaximal treadmill running (14.5--16.1 km/h, 20% grade) to exhaustion, on two duplicate tests separated by 48 h. Mean total oxygen debts on the two trials were 5.28 +/- 0.42 1 and 4.57 +/- 0.46 1, (r = 0.34). Mean alactic oxygen debts were... | 668,682 | [
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0.09585857,
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-0.2744016,
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0.4044838,
0.06354333,
-0.01706486,
0.0277542,
0.4563483,
0.2075... |
Effect of high pressure, detergents and phospholipase on the break in the Arrhenius plot of Azotobacter nitrogenase. | It is shown that lipids are responsible for the breaks in the Arrhenius plots of Azotobacter nitrogenase. The physical evidence is that temperature at which the break occurs increases with increasing pressure by 20 K/1000 atm. This is in agreement with the pressure dependence of the transition temperature of several sy... | 668,700 | [
-0.2165409,
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0.0291973,
0.002332137,
0.2412435,
0.1190242,
0.2271476,
-0.18011... |
Preliminary immunological studies in spinal muscular atrophy. | Evidence of impaired cell-mediated immunity in children with spinal muscular atrophy was obtained using lymphocyte transformation with PHA (20 children) and skin tests with tuberculin and DNCB (35 children). Laryngological examination of 16 children demonstrated hypoplasia of lymphatic tissue in Waldeyer's ring and the... | 668,717 | [
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0.1174793,
0.237326,
0.1434918,
0.144796,
-0.17... |
Attempted dietary treatment of a boy with hyperammonemia due to ornithine transferase deficiency. | Dietary treatment of a male patient suffering from the delayed-onset type of OCT deficiency was attempted. Control of the hyperammonemia was attempted by restriction of protein intake, guided by monitoring the plasma ammonia and regular checking of the serum amino acid levels. The influence of supplementary citric acid... | 668,733 | [
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0.06122893,
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0.3025162,
-0.08919674,... |
Eosinophilic cystitis. | 4 cases of eosinophilic granulomatous cystitis are reported. The clinical presentation of this rare entity is disucssed. It is suggested that the lesion is probably akin to eosinophilic enteritis or eosinophilic granuloma of the gastrointestinal tract and represents a local intense allergic reaction of eosinophilic typ... | 668,739 | [
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-... |
Retrocaval ureter. | 3 cases of retrocaval ureter (one of them presenting multiple urological anomalies) are discussed. In the presence of hydronephrosis, early operative reposition of the ureter is essential. Provided that the condition is diagnosed before extreme renal deterioration, the surgical repair can salvage remaining renal functi... | 668,740 | [
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-0.457368,
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0.190546,
-0.07202265,... |
Right and left ventricular flow during mechanical alternans. | Pulmonary and aortic blood flow simultaneous with right and left ventricular isometric tension were measured in anesthetized dogs during mechanical alternans induced by rapid atrial driving. It was found that any steady state of mechanical alternation can be altered to another steady state by a single premature or dela... | 668,752 | [
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0.1700339,
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0.05071086,
0.2333041,
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0.01195123,
0.06724925,
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0.04483668,
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-0.3156155,
0.2895373,
0.02302104,
-0.0162192,
... |
Antihypertensive effect of various doses of hydrochlorothiazide and its relation to the plasma level of the drug. | Nine previously untreated hypertensive patients (WHO Stage I and II) were given hydrochlorothiazide (hct) 12.5, 25, 50 and 75 mg for two weeks after an initial four week period of placebo treatment. Blood pressure recordings were made casually and after 30 min rest in lying, sitting and standing positions. Plasma conc... | 668,773 | [
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0.2442064,
-0.3280498,
-0.261161,
0.1192723,
-0.1343484,
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-0.02138975,
-0.2505622,
0.1175585,
0.3827319,
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0.004988437,
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0.20362,
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0.4150974,
0.009850809,
0.3768358,
0.04060691,
-... |
Paracetamol (acetaminophen) kinetics in patients with Gilber's syndrome. | The pahrmacokinetics of paracetamol after intravenous and oral administration has been studied in 6 patients with Gilbert's syndrome, and 6 healthy controls. Paracetamol clearance was significantly less in the patients (255 ml/min SE +/- 23 ml/min) than in the normal subjects (352 ml/min SE +/- 40 ml/min). Moreover, wh... | 668,775 | [
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0.009661284,
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0.1613246,
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0.01248806,
-0.007933639,
0.5431715,
0.06743451,
-0.1205565,
0.2606645,
-0.03483785,
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-0.4142509,
0.1132452,
-0.08156577,
0.2213119,
0.02961153,
0.1786098,
0.011576... |
Protein binding of salicylate in cutaneous hepatic porphyria. | (1) Plasma protein binding of salicylate was studied in 14 patients with cutaneous hepatic porphyria (CHP) and 11 normal subjects using ultrafiltration with centrifugation (membrane cones) and continuous ultrafiltrations. (2) Albumin and haemoglobin levels were significantly reduced in patients with CHP, and salicylate... | 668,790 | [
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0.01927678,
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0.185634,
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0.4153117,
0.3605535,
0.1865518,
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0.1056132,
-0.3688842,
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-0.1784211,
0.2012299,
-0.09180898,
0.09454359,
-0.2432993,
... |
Effect of diazoxide on capacitance vessels. | Haemodynamic changes after an i.v. bolus of diazoxide 300 mg were studied in 11 hypertensive subjects. A hypotensive effect due to a fall in total peripheral vascular resistance was found in all of them, but changes in the peripheral circulation were less regular. A uniform change in forearm blood volume, blood flow, v... | 668,792 | [
-0.09283029,
-0.06442898,
-0.261745,
-0.132864,
0.1643152,
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-0.02141913,
-0.0555117,
0.175073,
0.1968601,
-0.07683326,
-0.009052073,
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-0.5101101,
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0.116451,
-0.1166598,
0.3112106,
-0.09266198,
-0.07105605,
0.1249421... |
Influence of bed rest on the pharmacokinetics of phenazone. | The pharmacokinetics of a single dose of phenazone was studied in six objects while ambulant and during bed rest for 3 days. Elimination of the drug was followed for 12 h after oral and intravenous administration. The elimination rate constant and total body clearance were significantly increased during bed rest as com... | 668,797 | [
-0.04799176,
0.136694,
-0.1258066,
-0.09618969,
0.1265803,
-0.2776004,
-0.3611504,
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-0.2007461,
-0.03921054,
0.02741246,
0.08665948,
0.08595571,
0.1850765,
-0.4294831,
0.1760283,
-0.4592533,
0.3119494,
-0.1844878,
0.1709475,
-0.1174664,
0.2559994,
0.1674642,
... |
Evidence for independent genetic regulation of the expression of different antibody classes in anti-sheep red blood cell responses. | Three levels of variation are described in the response to sheep red blood cells (SRBC). Inbred strains of mice are distinguishable in terms of early or late kinetics of IgM response, high or low overall IgG response, and the relative expression of IgG1, IgG2a and IgG2b antibody in their response to SRBC. Results using... | 668,801 | [
0.0860929,
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-0.176834,
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0.2574649,
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0.03069952,
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0.03582541,
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-0.07671756,
0.2300195,
0.3497996,
0.07408104,
-0.008442374... |
Effects of phenytoin on sympathetic reflex responses in the cat. | Phenytoin (DPH), in a low dose (2 mg/kg) was found to potentiate reflex elevations in blood pressure and responses of the nictitating membrane induced either by the electrical stimulation of the sciatic nerve or by intravenously applied pentetrazol in light anaesthetized cats. Pressor responses to carotid occlusion und... | 668,808 | [
-0.07831216,
-0.1389503,
-0.253558,
0.03788339,
0.0009171398,
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-0.08816685,
-0.2986789,
0.09324117,
0.05417481,
-0.0759732,
-0.1008058,
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-0.5679526,
0.1839247,
-0.1776086,
0.2227672,
0.01524142,
0.1599814,
0.090... |
Indomethacin and diclofenac sodium increase sodium and water excretion after extracellular volume expansion in the rabbit. | The renal effects of an acute extracellular fluid volume expansion (50 ml Ringer/kg body weight/60 min) were studied in aldosterone-treated (100 microgram/kg), anesthetized rabbits with and without pretreatment with either indomethacin (3.0 mg/kg) or diclofenac sodium (3.0 mg/kg), two different inhibitors of renal pros... | 668,809 | [
-0.05028921,
0.2107912,
-0.5890983,
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0.2994039,
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0.0235281,
0.06294279,
0.1983102,
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-0.1086217,
0.3805895,
0.2893759,
0.2902987,
-0.02998941,
0.07367887,
-0.2526138... |
Studies on mast cells of Rana tigrina. | Mast cell degranulators cause vasoconstriction in the frog. A comparative study of the mesenteric mast cells of the frog and rat showed that the frog mast cells differed from those of the rat in having a dense perigastric instead of a sparse ideal distribution, and in responding to compound 48/80 by a rapid and marked ... | 668,813 | [
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0.02867391,
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0.1739797,
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0.1946121,
0.1076401,
0.2890917,
0.02152397,
0.2770515,
0.0008165858,... |
[Comparative studies on lactate dehydrogenase in serum and plasma of rats (author's transl)]. | Values of serum and plasma LDH in rats were comparatively studied, and the following results were obtained: 1) The activity of LDH increased in serum with time during clotting, but no changes of LDH activity were found in plasma. 2) When platelet rich plasma (PRP) was recalcified and allowed to clot, LDH-release from p... | 668,815 | [
-0.03631888,
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0.0188306,
0.1384663,
0.3853207,
0.1133806,
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0.009984366,
0.1034203,
0.5722401,
0.4677785,
0.08343111,
-0.074020... |
Aflatoxin B1 hepatotoxicity in rats pretreated with ethanol. | Ethanol pretreatment has the potentiation of the aflatoxin B1-induced hepatotoxicity was indicated by an increase in the activities of plasma GPT, plasma GOT and in the severity of liver necrosis. The effect of ethanol pretreatment on an increase in the accumulation of liver triglycerides is additive in nature. | 668,855 | [
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0.09257129,
0.2736587,
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0.2255738,
0.1465686,
0.3243198,
-0.108... |
[The effect of the polymeric quaternary ammonium salt,2,5-ionene on blood coagulation]. | In modelling overdosages of the polymeric antagonist in cases of heparin neutralization the effect of 2.5-ionene on the blood coagulation in rabbits was considered during investigations in vivo. It is shown that even appreciable overdosages of 2.5-ionene are not attended by the effect of hypocoagulation. Shortening the... | 668,865 | [
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0.1960257,
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0.1641484,
0.2298456,
0.639652,
0.09445748,
0.05353547,
... |
[Kinetics of accumulation and elimination of 14C-dipine, an antineoplastic drug]. | An investigation on evaluating the distribution of 14C-dipine in rats with sarcoma 45 was carried out. With intragastric administration of the drug its resorption occurs largely in the small intestine. The maximally absorbed portion of the tag is detected in 1 hour and by this time it reaches 36.4 per cent of the intro... | 668,875 | [
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0.2502228,
0.07022622,
0.6334168,
0.1616226,
0.2604497,
-0.01114114... |
A longitudinal analysis of artificial insemination with donor semen. | A longitudinal analysis of artificial insemination with donor semen (AID) in 114 consecutive couples revealed a 37% over-all pregnancy rate. The 45 pregnancies occurred in 39 patients, and approximately 90% of these pregnancies occurred within six cycles of AID. Pregnancy rates were higher in the age group 25 to 30, in... | 668,934 | [
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0.1443923,
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0.04782053,
0.1904726,
0.4063473,
-0.1770157,
... |
Intrauterine insemination of isolated motile sperm. | Semen from infertile males was filtered through liquid albumin, and sperm retrieved from the most distal fraction were used for intrauterine insemination. Compared with the ejaculate, the isolated specimens contained fewer sperm but an increased percentage of motile sperm. The fractions were also free of the debris (wh... | 668,936 | [
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0.03224551,
-0.2792427,
0.1212709,
0.08464415,
-0.08047121... |
Serum uric acid levels in untreated and PUVA-treated patients with psoriasis. | Hyperuricemia occurs frequently in patients with psoriasis. An increased purin breakdown due to the enhanced epidermal turnover was stressed as a reasonable explanation. To prove this theory serum uric acid, cholesterol, triglyceride levels and the average body overweight were determined in 318 untreated psoriatic pati... | 668,975 | [
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0.6533335,
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0.02137961,
0.0724877,
0.1082491,
0.128295,
0.3613008,
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0.2977246,
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0.0260304,
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0.02890354,
0.242813,
0.3212253,
-0.5072206,
-0.1... |
Plasma glucose and insulin in the hibernating hedgehog. | Plasma glucose and insulin have been studied during lethargy and spontaneous arousal of hibernating hedgehogs. During lethargy, plasma glucose and insulin were low and showed no variation. Glucose and insulin injections given during lethargy showed no effects on plasma insulin and glucose respectively but confirmed a v... | 668,977 | [
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-0.4938896,
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0.04511529,
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-0.4346508,
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0.01459016,
0.08652758,
0.4002377,
0.1814259,
-0.3105016,
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0.08547137,
0.005213544,
-0.482789,
0.1991545,
0.05928524,
-0.09822015,
0.09876228,
0.1184081,
0.04981599... |
[Metabolism of capillary endothelium tissue and its abnormalities in diabetes mellitus (author's transl)]. | Glucose is the major energetic substrate of blood capillary endothelium; aerobic glycolysis is quantitatively the most important pathway. Insulin has no direct effect on glucose utilization. The glucokinase activity of the capillary endothelium is undetectable and the plasma cell membrane is freely permeable to glucose... | 668,982 | [
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0.2109531,
0.1111149,
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0.1689853,
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0.01076588,
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0.2329749,
-0.109704,
0.152231,
0.5327066,
0.2282626,
0.1489702,
-0.2974... |
Effect of early weaning of the neonatal rat on pancreatic acinar cell responsiveness to urecholine. | Pancreatic response to urecholine was studied in rats weaned prematurely on the morning of their 13th, 15th, 17th and 19th day and killed 2 1/2 days later. In pups kept with their mother and weaned at 21 days, amylase chymotrypsin and lipase concentrations increased gradually. Weaning after 12, 14 and 16 complete days ... | 669,078 | [
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0.08735315,
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0.09894501,
0.4835554,
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-0.4171802,
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-0.1638605,
0.127946,
0.3003649,
0.2455159,
0.0670... |
Pancreatic polypeptide, glucagon and insulin secretion from the isolated perfused canine pancreas. | The release of pancreatic polypeptide (PP) by gut hormones, acetyl choline and adrenaline was investigated in an isolated perfused pancreas preparation. PP was potently released by 1 nmol/1 caerulein (186 +/- 12%, p is less than 0.001) and gastric inhibitory peptide (GIP) (211 +/- 31%, p is less than 0.005) as well as ... | 669,104 | [
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0.1918725,
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0.1201335,... |
[Mitral and aortic regurgitation: a rare association in ankylosing spondylitis (author's transl)]. | The occurrence of mitral regurgitation in ankylitis is very unusual. The case reported herein is a remarkable one because the subaortic bump at the base of the anterior mitral leaflet, the mose characteristic aspect of the heart involvement in this disease, was visualized for the first time by echocardiography. Moreove... | 669,114 | [
-0.3945384,
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0.3441566,
0.53002,
0.1894318,
-0.00804... |
[Clinical and angiographic observations in aneurysm of the membranous septum. Pathologenetic implications]. | Aneurysm-like kialations of the membranous septum are described with increasing frequency in association to a ventricular septal defect (VSD). Their etiology may be congenital, though with different pathogenesis and acquired. An anatomical distinction between true aneurysm of the membranous septum and pseudoaneurysm is... | 669,119 | [
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0.1416828,
0.007054879,
0.4410437,
-0.07359172,
-0.104... |
Esophageal stricture secondary to candidiasis. | Esophageal candidiasis may rarely progress to stricture formation. All patients reported to date with stricture due to candidiasis have had an underlying immunologic deficiency or were undergoing chemotherapy for malignancies. Early diagnosis and adequate anti-fungal therapy are recommended to prevent this disabling co... | 669,154 | [
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0.2408044,
0.1802627,
0.046227... |
Radiologic demonstration of multiple foci of malignancy in the esophagus. | Three patients, each with two synchronous esophageal carcinomas demonstrated radiologically, are presented. The importance of complete esophageal evaluation in patients with one obvious tumor of the esophagus is emphasized. Assessment of the full extent of disease in such cases directly affects treatment planning. | 669,163 | [
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0.398452,
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0.... |
Hypotonic duodenography--too often performed but of too little value? A comparison with conventional spot films. | Hypotonic duodenography was compared with conventional barium examination in 68 patients (70 examinations) with clinically suggested or verified disease of the pancreas or duodenum. In 13 cases (18.5%) conventional examination demonstrated the duodenal anatomy better than hypotonic duodenography. In nine cases (13%) hy... | 669,182 | [
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0.06001632,
0.04015586,... |
Use of the C-terminal octapeptide of cholecystokinin in clinical radiology. I. The gallbladder. | Two 30-min. infusion doses of the octapeptide of chloecystokinin (C8-CCK) (1 and 4 ng/kg/min) produced equal and consistent gallbladder contractions (75 +/- 8% mean and SEM decrease in size) in 24 human volunteers. The long 30-min infusion method of C8-CCK administration appears better than bolus injection (30 to 180 s... | 669,185 | [
-0.1888361,
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0.1211461,
0.1381011,
0.3252361,
0.2195991,
0.05244017,
0.1535... |
Radiologic findings in anorectal gonorrhea. | Gonorrhea is the most prevalent communicable disease in the United States and the incidence of anorectal involvement is high. Anorectal gonorrhea may be clinically elusive making the radiologic findings crucial in suggesting the diagnosis. Edematous rectal mucosa with limited distensibility and small ulcerations are th... | 669,190 | [
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0.0570765,
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-0.02042753,
0.1073744,
0.00104143... |
Therapeutic effect of histidine decarboxylase inhibitor on chronic active hepatitis. | The effect of orally administered histidine decarboxylase inhibitor on liver function tests and histological appearance as well as on plasma histamine level were evaluated in biopsy proven 13 patients with chronic active hepatitis, whose liver function tests were refractory to other measures. Tritoqualine was used as h... | 669,195 | [
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-0.2781684,
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0.1591599,
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0.1214415,
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0.3542566,
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0.1887228,
-0.008806132,
-0.0... |
Nodular regenerative hyperplasia of the liver. Report of six cases and review of the literature. | The authors report the cases of 6 adult patients suffering from nodular regenerative hyperplasia of the liver, an uncommon lesion characterized by small-sized hepatocytic nodules scattered throughout the liver, with no or slight fibrosis. The histological recognition of nodular regenerative hyperplasia of the liver was... | 669,201 | [
-0.2532948,
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-0.1827498,
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0.1133526,
-0.02416774,
-0.129505... |
[Comparison of nipple care in the Puerperium with powder and ointment (author's transl)]. | Recommendations for the care of the nipple postpartum are numerous and variable. Cracks and fissures in the nipple must be prevented to prevent mastitis. A randomized prospective study shows that it does not matter whether powder or ointments or nothing is placed on the nipples after nursing. The incidence of cracked n... | 669,246 | [
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0.1004679,
0.3151741,
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0.2454565,
-0.202592,
-0.027359... |
Genetics of hemoglobin in the deer mouse, Peromyscus maniculatus. I. Multiple alpha- and beta-globin structural loci. | Genetic data, together with molecular structure studies, have demonstrated that the complex hemoglobin phenotypes in four subspecies of P. maniculatus are generated by at least four, and probably five, globin structural loci. The Hba and Hbc loci apparently arose by duplication of an ancestral alpha-type locus, while H... | 669,255 | [
0.06039691,
0.2952106,
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0.0888631,
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0.1587664,
0.08952393,
0.03417078... |
[Role of the genetic-physiological interrelationships of mother-progeny in establishing the viability and fertility of mammals. II. The weight of the embryos of BALB, CBA and DBA strain mice developing from transplanted blastocysts]. | The weights of embryos and their placentas obtained by blastocysts of CBA/LacY and DBA/2 mouse strains transfer in recipient females of BALB/c strain and also by blastocysts of BALB/c mouse strain transfer in recipient females of CBA/LacY strain were analysed on the 16th gestation day. It is shown that placental weight... | 669,262 | [
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0.05622952,
0.321588,
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0.1672624,
0.08643198,
0.3149288,
-0.102861... |
Time-dependency of serum carbamazepine concentration. | Serum CBZ concentration was determined by gas liquid chromatographic method in 14 epileptic patients (32 samples) treated initially with CBZ alone, and the following results were obtained: 1. The relationship between serum CBZ concentration and CBZ dose was expressed by a regression line that sloped sharply upwards at ... | 669,497 | [
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0.202346,
0.4218447,
0.02237434,
-0.... |
[Study report on the lack of interaction between mianserine and noradrenaline in man]. | Tricyclic antidepressants are known to potentiate the increase in blood pressure caused by noradrenaline. Five depressive patients were given intravenous noradrenaline before and after 2--4 weeks of treatment with Org GB 94 (Tolvin). The dose of noradrenaline was increased until a rise of 30 mmHg in systolic blood pres... | 669,524 | [
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0.08209269,
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0.4983719,
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0.4460116,
0.1043327,
-0.1086898,
0.01453236,
0... |
[Functional effects of micro-oil embolization following lymphography]. | Lymphography, if performed correctly, has few clinically relevant complications. Nevertheless, the passage of oily contrast medium into the pulmonary vascular bed along physiological pathways can usually be verified radiographically and functionally. Since that part of the contrast medium filtered in the lungs is of no... | 669,530 | [
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0.272331,
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0.07555201,
0.2089306,
... |
[Ambulatory blood sugar control of diabetics on insulin therapy during pregnancy by means of the Eyetone reflectometer]. | The data obtained in this study show that sufficiently accurate blood glucose values can be obtained by the pregnant diabetic with the Eyetone reflectometer. It is possible to lower the blood glucose value of the pregnant diabetic to the normal range as soon as pregnancy is confirmed. Prolonged hospital confinement can... | 669,544 | [
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0.09565829,
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0.02552071,
0.1292434,
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0.2111229,
... |
[A clinical study with apexcardiogram, kinetocardiogram and carotid pulse tracing in aortic insufficiency (author's transl)]. | The apexcardiogram, kinetocardiogram and carotid pulse tracing were studied in 24 normal subjects and 20 patients with aortic insufficiency. The electrocardiogram and phonocardiogram were recorded simultaneously as the time reference. The study of the carotid pulse tracing and systolic time intervals was made using the... | 669,560 | [
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0.08232859,
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0.1292528,
0.1860435,
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0.2719462,
0.1996619,
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0.08836702,
-0.5431746,
-0.04602952,
-0.3285591,
0.4888655,
0.706188,
-0.2793354,
0.2415249,
... |
Effects of melatonin and natural and synthetic analogues of arginine vasotocin on plasma prolactin levels in adult male rats. | A significant elevation in plasma prolactin was observed 10 min following the intravenous injection of 100 microgram of melatonin into either estrogen-progesterone (EP) primed or into nonsteroid-treated male rats. 60 min postinjection in the EP primed rat, the groups treated with 100 microgram or 10 mg of melatonin had... | 669,573 | [
0.02189159,
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0.07073571,
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Snake venoms. The amino-acid sequence of protein S5C4 from Dendroaspis jamesoni kaimosae (Jameson's mamba) venom. | A major component (S5C4) was purified from Jameson's mamba by gel filtration on Sephadex G-50 and by ion-exchange chromotography on CM-cellulose. Protein S5C4 contains 60 amino acid residues and is cross-linked by four intrachain disulphide bridges. The complete primary structure of the protein has been elucidated. The... | 669,583 | [
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0.4814182,
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0.4624969,
0.2273099,
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A conceptual approach to deinstitutionalization. | Many serious problems in deinstitutionalization result from conceptual oversights or confusion. Understanding deinstitutionalization as a process and a philosophy, as well as a fact, permits planning that will accommodate the variety of patient populations that are the products of the deinstitutionalization movement. T... | 669,607 | [
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0.09245... |
Function of hospital-based planner must match organizational need. | Different types of hospital-based planners perform different functions and assume different degrees of authority. A hospital must assess its planning needs and the characteristics of each type of planner in order to hire properly. The hospital staff members and the planner then must accommodate each other's work styles... | 669,639 | [
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0.07218137,
0.0524005... |
Distribution of G6PD phenotypes in red blood cells of Southern African Negroids: evidence for somatic selection. | In a recent population study, we observed a striking deficit of G6PD heterozygotes among Southern African Negroid females. This finding was interpreted tentatively as evidence for a small number of hematopoetic stem cells in man. In a follow-up study we examined peripheral blood and cord blood in 547 mothers and in the... | 669,705 | [
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0.2780223,
0.4265629,
-0.071226... |
Trisomy-8 mosaicism: report of a case. | An 8-year-old male with mental retardation, speech difficulties, and minor congenital anomalies is presented. The clinical findings suggest the trisomy-8 syndrome. The karyotype indicates trisomy-8 mosaicism with trisomic as well as normal cell lines in blood lymphocytes. | 669,713 | [
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0.204817,
0.09597953,... |
Investigations on the PGMa1 polymorphism (phosphoglucomutase--EC 2.7.5.1) by isoelectric focusing. | The determination of phosphoglucomutase (PGM1) phenotypes was performed by isoelectric focusing on samples from 1678 unrelated individuals from Hessen, Germany. Ten common phenotypes are considered as gene products of four alleles at the PGM1 locus with the following frequencies: PGMa1(1) = 0.6305, PGMa2(1) = 0.1844, P... | 669,719 | [
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0.04127454,
0.4135251,
0.3897313,
0.12961,
... |
DNA, RNA and protein content of tissue during growth and embryogenesis in wild-carrot suspension cultures. | A highly selected population of cells (clumps from 63 to 125 micron in diameter), obtained by screening 14-day-old stock suspension cultures of wild carrot (Daucus carota L.), was used to initiate cultures in this study. Time-course changes in DNA, RNA and protein were followed when these cultures were grown in the pre... | 669,724 | [
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0.09326769,
0.2955,
0.5914568,
0.199327,
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-0.0437... |
Cell cycle analysis and synchronization of the TN-368 insect cell line. | A cell cycle analysis of the Trichoplusia ni (TN-368) insect cell line is described. By means of autoradiography and percent labeled metaphase data, the cell cycle parameters were determined to be as follows: S, 4.5 hr; G2, 8.5 hr; M, 0.5 hr; G1, 1.0 hr; the total cell time being 14.5 hr. A synchronization procedure us... | 669,727 | [
0.1266686,
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0.4782259,
0.6633545,
-0.1379522,
... |
In vitro analysis of proliferating epithelial cell populations from the mouse mammary gland: fibroblast-free growth and serial passage. | Normal and neoplastic mouse mammary epithelial cells were cultured in nutrient medium containing D-valine substituted for L-valine. Fibroblast overgrowth was prevented and epithelial cell functions and morphology were retained in cultures maintained in D-valine medium up to 2 months. A nonenzymatic technique was devise... | 669,728 | [
-0.2868665,
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0.2219197,
0.1883939,
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Innate resistance of mice to experimental infection with Naegleria fowleri. | The mouse system provides an excellent model for studying host resistance to Naegleria fowleri, the agent of primary amoebic meningoencephalitis. Innate resistance to infection with N. fowleri was examined with respect to infecting dose and the age, sex, and strain of mice. Intravenous inoculation with 10(7) amoebae pe... | 669,800 | [
-0.3300946,
-0.5794874,
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-0.3957715,
0.09880774,
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0.3932423,
-0.4705586,
0.07673255,
0.04482548,
0.3396806,
0.06724828... |
Delayed-type hypersensitivity in mice immunized with Trypanosoma rhodesiense antigens. | When mice were immunized intravenously, subcutaneously, or by the footpad route with formaldehyde-killed Trypanosoma rhodesiense, delayed-type hypersensitivity was elicited by the use of frozen-thawed trypanosomal antigen. The delayed footpad swelling technique was used to measure delayed hypersensitivity. Hypersensiti... | 669,805 | [
-0.1694524,
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0.3099739,
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0.3602903,
0.01213977,
-0... |
Antigenic analysis of coccidioidin and spherulin determined by two-dimensional immunoelectrophoresis. | Immunological tests are valuable aids for diagnosis of mycotic infections and, in some cases, as objective guides for clinical management and prognosis. The usefulness of these procedures is limited to the extents that crude antigen preparations are employed, that these are difficult to standardize uniformly, and that ... | 669,811 | [
-0.04859736,
0.1002134,
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0.02102982,
0.009255794,
0.1412025,
0.4004281,
-0.1... |
Effect of cytochalasin D on Toxoplasma gondii cell entry. | Cytochalasin D did not prevent attachment but did prevent entry of Toxoplasma gondii into peritoneal macrophages and bladder tumor 4934 cells. Inhibition of entry of T. gondii into peritoneal macrophages by cytochalasin D was dose related and comparable to inhibition of phagocytosis. Prevention of entry of T. gondii in... | 669,821 | [
-0.2263505,
-0.03243015,
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0.09899761,
0.478828,
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0.17905,
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0.1121842,
0.05499207,
0.3437136,
-0.1613769,
0.4... |
Scanning electron microscopy of lymphoid cells from leukemia virus-infected mice. | Spleen, lymph node, bone marrow, and thymus cells from Friend leukemia virus (FLV)-infected mice were examined by scanning electron microscopy. Whereas splenocytes from normal, noninfected animals showed the expected morphological classes of lymphocytes, including cells with numerous villous projections and smoother ce... | 669,822 | [
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0.2194,
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0.04013634,
-0.037114,
... |
Toxicity of emulsified trehalose-6,6'-dimycolate (cord factor) in mice depends on size distribution of mineral oil droplets. | Toxicity of emulsified trehalose-6,6'-dimycolate administered intravenously into mice depended on the size distribution of the mineral oil droplets. Emulsions containing the greatest number of the largest oil droplets were the most toxic. Emulsions of trehalose-6,6'-dimycolate made with peanut oil or with olive oil wer... | 669,824 | [
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0.1205247,
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0.02131023,
0.3209555,
0.1436146,
-0.0191... |
Suppression of Staphylococcus aureus extracellular nuclease and alpha-toxin synthesis by acetylmethylcarbinol. | Acetylmethylcarbinol added to the inoculated culture of Staphylococcus aureus Wood 46 suppressed 85% of the differential rates of extracellular nuclease and alpha-toxin. | 669,826 | [
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-0.3187952,
0.04145328,
0.06210307,
0.3181584,
0.4034447,
0.1301489,
-0.3391053,... |
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