title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Cells of origin of subcortical afferents to the caudate nucleus: a horseradish peroxidase study in the cat. | The horseradish peroxidase tracing method was used to investigate the sources of subcortical input to the caudate nucleus in the cat. Of considerable interest was the finding, not previously described, that labeled neurons were present outside of the intralaminar complex, in the ventral anterior and mediodorsal thalami... | 698,789 | [
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On the appearance of acetylcholine receptors in denervated rat diaphragm, and its dependence on nerve stump length. | Acetylcholine (ACh) sensitivity and extrajunctional receptor distribution of the rat diaphragm were closely monitored during the early period following denervation. Both contracture in response to 10 microgram/ml of ACh and extrajunctional binding of [125I]alpha-bungarotoxin ([125I]alpha-BTX)) were first detectable 30 ... | 698,793 | [
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Presence of a pineal nerve (nervus pinealis) in the human fetus: a light and electron microscopical study of the innervation of the pineal gland. | The presence of a hitherto undiscovered nerve located in the subarachnoidal space just caudal to the pineal organ, connecting this organ and the posterior commissure, was demonstrated by light and electron microscopy in a series of 18 human fetuses. This nerve is believed to be ontogenetically equivalent to the pineal ... | 698,804 | [
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Specific glycine uptake by identified neurons of Aplysia californica. I. Autoradiography. | The identified giant neurons R3-R14 in the Aplysia parietovisceral ganglion (PVG) have a rapid, Na+-dependent and Hg2+-sensitive uptake system for glycine not found in neighboring neurons. In autoradiographs of PVG incubated in [3H]glycine (glutaraldehyde fix), the cytoplasms of R3-R14 have 3--4 times more silver grain... | 698,819 | [
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Tetrodotoxin sensitivity and Ca component of action potentials of mouse dorsal root ganglion cells cultured in vitro. | In the mouse dorsal root ganglia cultured in vitro, neurons were classified into 3 groups according to the responses of their action potentials to tetrodotoxin (TTX) and removal of Na ions from bathing medium: (1) the neurons whose action potentials were not affected by TTX by TTX (10(-6) - 10 (-5)g/ml) and which gener... | 698,823 | [
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Cupular movement and nerve impulse response in the isolated semicircular canal. | The aim of the study was to record nerve impulse responses to controlled displacements of the cupula and relate these to observations of cupular motion. The preparation was the skate semicircular canal, isolated and maintained in a chamber. The canal was cut and tied tightly to an oil-filled tube driven by a 1 microlit... | 698,838 | [
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Hiccup and ephedrine. | Twelve patients who developed hiccup during anaesthesia and surgery were treated successfully with an intravenous injection of ephedrine 5 mg (eleven cases) or 10 mg (one case). In nine patients ephedrine was successful after traditional methods had been tried and failed, and in three patients ephedrine was the only ag... | 698,875 | [
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Cutaneous Hodgkin's disease: indolent course and control with chemotherapy. | A case of nodulat sclerosing Hodgkin's disease in an elderly woman is presented. Following radiotherapy, widespread lymphomatous skin lesions developed anatomically unrelated to her nodal disease. These lesions have been controlled, but not eliminated by chemotherapy. Cutaneous manifestations of Hodgkin's disease are d... | 698,912 | [
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Long-term organ culture of human uterine endocervix. | Explants of human endocervix have been maintained in organ culture for 24 weeks. The epithelium was viable for the entire duration of culture, as demonstrated by ultrastructural morphology and mitotic activity. The epithelium of the explants retained a near normal morphology for 2 to 4 weeks. The only changes observed ... | 698,932 | [
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Restoration by adrenalectomy of weight and binding capacity of glucorcorticoid receptors of the thymus in AH 130 tumor-bearing rats. | The binding capacity of specific receptors for dexamethasone (11beta,17alpha,21-trihydroxy-9alpha-fluoro-16alpha-methyl-1,4-pregnadiene-3,20-dione) in the cytoplasm of the thymus of rats bearing AH 130 (solid-type) tumors decreased significantly during tumor growth. Adrenalectomy restored the binding capacity of the gl... | 698,964 | [
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Haemodynamic effects on the myocardial blood flow supply/oxygen demand ratio in pacing induced angina pectoris. | Angina pectoris results from an imbalance between oxygen supply and demand in the subendocardium. The haemodynamic effects contributing to this imbalance have been studied in 10 patients with coronary artery disease. Myocardial oxygen demand was estimated from the tension time index (TTI), potential subendocardial flow... | 698,987 | [
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Early development of noradrenaline-containing sympathetic nerves in the choroid plexus system of the rabbit. | The development of the adrenergic sympathetic innervation of the rabbit choroid plexus system was studied prenatally and up to two months after birth by a combination of fluorescence histochemistry (formaldehyde and glyoxylic acid methods) and quantitative enzymatic determinations of noradrenaline. The first signs of a... | 699,012 | [
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An autoradiographic study on the biosynthesis of the capillary basal lamina in the chick embryo telencephalon. | The elaboration of the basal lamina of telencephalic capillaries has been studied by autoradiography in chick embryos from day 16 to 19 of incubation. The cerebral vascular basal lamina is actively synthesized during the period of these stages of development. The animals were sacrificed 2, 15, 40 and 180 min after intr... | 699,018 | [
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A possible mammary stem cell line. | The cell line Rama 25 is derived from a mammary tumor induced in a rat by dimethylbenzanthracene. During rapid proliferation, Rama 25 cells appear as a single undifferentiated epithelial type; at high cell densities, however, small numbers of two other cell types are formed, which respectively resemble secretory and my... | 699,048 | [
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Post-meiotic gene activity in spermatogenesis of the mouse. | Mouse male germ cells at middle-late pachytene and early spermatid stages obtained by velocity sedimentation at unit gravity in albumin gradients were labelled in culture with [3H]uridine. The newly synthesized RNAs extracted from polysomes of the 2 cell types were studied by sucrose gradient fractionation and poly(U) ... | 699,051 | [
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[Lymphoepitheloid malignant lymphoma (Lennert)]. | A group of 22 lymfoepitheloid malignant lymphomas was singled out from a wider group by means of demonstating nuclear atypias in epitheloid cells. There were three roughly equal subgroups: the first corresponding to malignant lymphogranuloma, the second to different malignant lymphomas of the ono-Hodgkin type. At first... | 699,110 | [
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[Arthrotic manifestations on the patella in the x-ray and microscopy pictures]. | 40 patellae of different age groups were examined by X-ray and histology. X-ray changes found in the cartilage, corticalis and cancellous bone were in full agreement with histological findings. However, more than a quarter of the patellae were found to be affected by microscopic fibrillation of the surface of the carti... | 699,111 | [
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Epoxide metabolizing enzyme activities in rat testes: postnatal development and relative activity in interstitial and spermatogenic cell compartments. | Microsomal epoxide hydrase (EH) and 176 000 g supernatant fraction glutathione-S-transferase (GSH-S-T) activities were determined with styrene oxide as substrate in rat testes during postnatal development. The development of these enzymes was also followed in liver for comparison. Testes of 6-day-old rats had high GSH-... | 699,170 | [
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Mutagenicity of dichlorvos and other structurally related pesticides in Salmonella and Streptomyces. | The following pesticides: azinphosmethyl, diallate, dichlorvos, EPTC, fenchlorphos, mevinphos, monocrotophos, noruron, parathionmethyl, triallate, trichlorphon and vegadex were tested for the ability to induce his+ revertants in four histidines requiring strains of Salmonella typhimurium--TAI 535(missense), TAI 536, TA... | 699,179 | [
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Computer-generated graphic models of the N2-substituted deoxyguanosine adducts of 2-acetylaminofluorene and benzo[a]pyrene and the O6-substituted deoxyguanosine adduct of 1-naphthylamine in the DNA double helix. | Computer models of three deoxyguanosine-carcinogen adducts in double-helical DNA are presented. The carcinogen moiety is rotated and the best fit within the double helix is evaluated. The 2-acetylaminofluorene (AAF) derivative, 3-(deoxyguanosin-N2-yl)-AAF, is found to be situated within the minor groove, has very littl... | 699,181 | [
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[Incidence of recurrent nerve paralysis in personal cases of thyroid surgery]. | The authors review their series of thyroid operations, totaling 383 cases in the last seven years. In that series the incidence of recurrent nerve lesions leading to permanent sequels was 1.07% (all treated without surgical preparation of the nerve); an additional 0.53% of the patients developed transient paralysis of ... | 699,223 | [
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[Personal experience with anterior resection of the rectum]. | Authors experience in the Dixon's operation regarding the surgical treatment of cancer of the rectum and recto-sigmoid junction is reviewed. It consists in 224 cases of malignant lesions which were treated by Miles operation (106 cases--47%), Dixon's operation (49 cases--21%), palliation anterior resection (16 cases--7... | 699,228 | [
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Noninvasive assessment of left ventricular function from the mitral valve echogram. Relation of final anterior mitral leaflet closing velocity to peak dp/dt and aortic velocity. | Since final mitral valve (MV) closure and aortic ejection velocity are mediated by the same forces in early left ventricular (LV) contraction, the rate of final MV closure (BC slope) should reflect LV performance. We first verified whether peak final closing velocity (ds/dt) of the anterior MV leaflet (AMVL) is related... | 699,251 | [
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Stability of blood pressure rank and urinary kallikrein concentration in childhood: an eight-year follow-up. | Previous studies in a population of 721 children aged 2--14 years demonstrated the familial aggregation of blood pressure in children, and a significant regression coefficient (b = 0.25) of follow-up on initial blood pressures over a four-year period. Urinary kallikrein concentration (UKal) also aggregated in families,... | 699,259 | [
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Automated metabolic profiling of organic acids in human urine. I. Description of methods. | We describe a complete procedure for separation and mechanized analysis of organic acids in human urine. The acid fraction of urine is separated by anion-exchange chromatography on diethylaminoethyl-Sephadex. Individual acids are identified and measured by use of a gas-chromatography/mass spectrometer/computer system t... | 699,272 | [
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Negative-ion mass spectrometry of amphetamine congeners. | Negative-ion chemical ionization mass spectrometry with a conventional combined gas chromatograph-mass spectrometer has been used for the analysis of amphetamine-like compounds. Ammonia was used as the reagent gas, which gives rise to few but specific sample-fragment ions, such as (M--1)- as the base peak, m/z 91, and ... | 699,276 | [
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Enzymic micro-assay for blood glutamine. | Blood glutamine is hydrolyzed by glutaminase; the resulting ammonia is dialyzed out and measured by use of a continuous-flow colorimetric microassay. Concentrations in the range of 10 to 1300 micromol of glutamine per liter can be determined in a 40-microliter sample. With slight modifications, higher concentrations, u... | 699,278 | [
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High-performance liquid-chromatographic determination of free nicotinic acid and its metabolite, nicotinuric acid, in plasma and urine. | We report a liquid-chromatographic procedure for determining free nicotinic acid and a metabolite, nicotinuric acid, in plasma and urine. Five-tenths milliliter of urine or deproteinized plasma is evaporated and the residue analyzed isocratically by reversed-phase ion-pair chromatography, with measurement of the eluted... | 699,281 | [
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Reduced-volume radioimmunoassays for parathyrin and calcitonin in serum, for use in pediatric and small-animal studies. | Radioimmunoassays for circulating parathyrin and calcitonin used in most laboratories require 0.6--0.7 ml of serum or plasma, or more, for assay of one hormone. Such volumes are often difficult to obtain safely or repeatedly from pediatric patients or in small-animal studies. We modified our existing procedures to mark... | 699,296 | [
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Use of a chromogenic substrate for the diagnosis of Krabbe's disease, with special reference to its application in prenatal diagnosis. | A chromogenic substrate, 2-hexadecanoylamino-4-nitrophenyl-beta-D-galactopyranoside, has recently been described for the diagnosis of Krabbe's disease. Hydrolysis of this substrate by extracts of cultured cells and tissues was compared with the activities of lactocerebrosidase I and non-specific beta-galactosidase. Und... | 699,319 | [
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Serum methionine: its rapid determination by continuous-flow colorimetry. | A rapid automated method for the determination of serum methionine is presented for use with the Technicon AutoAnalyzer system. It is based on the decolorisation of halide platinates by organic sulphides, including methionine. The 5--95% reference range from 249 sera from hospital patients (excluding those with liver a... | 699,322 | [
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[Potentiometric determination of hepatitis B surface antigen in biological fluids (author's transl)]. | The present report describes a sensitive and reliable method for potentiometric determination of hepatitis B surface antigen in biological fluids, as an application of enzyme-linked immunoassay technique by a "sandwich" procedure. Specific antibodies are immobilized on a gelatine membrane which covers the sensor of an ... | 699,328 | [
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A practical proposal for arginine-vasopressin radioimmunoassay. | This work proposes the use of (a) a commercially available homologous system AVP antibody-AVP (Arginine Vasopressin) standard and (b) new acquisitions for the improvement of sensitivity for AVP radioimmunoassay by separate or simultaneous use of two-phase sequential incubation and epsilon-aminocaproic acid (EACA). The ... | 699,331 | [
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The quantitative determination of 5-S-cysteinyldopa and dopa in normal serum and in serum from patients with malignant melanoma by means of high-pressure liquid chromatography. | A method is described for quantitative determination of 5-S-cysteinyldopa and Dopa in serum involving high-pressure liquid chromatographic analysis (HPLC) and electrochemical detection. The chromatographic system allows estimation of injected amounts corresponding to 25 pg of 5-S-cysteinyldopa and Dopa. In normal subje... | 699,334 | [
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A simple and rapid method for the estimation of serum haemoglobin binding capacity on Ultrogel AcA 44. | A method is described for the estimation of serum haemoglobin binding capacity. The method is based on the separation of the high molecular weight haemoglobin . haptoglobin complex formed after addition of haemoglobin in excess to serum from uncomplexed haemoglobin by gel filtration through Ultrogel AcA 44. Agar gel el... | 699,342 | [
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A simple modification to an LKB 8600 reaction rate analyser for rapid measurement of enzymes showing lag phases in a coupled system. | An enzyme assay which utilizes a coupled enzyme system may show a lag phase. To help to overcome problems associated with the kinetic measurement of these enzymes a modification to an LKB 8600 reaction rate analyser is described. It has been applied successfully to a kinetic method for the measurement of 5'-nucleotidas... | 699,345 | [
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An XYY boy with short stature and a case of Klinefelter's syndrome (XXY) in a family with inversion 9. | A patient with Klinefelter's syndrome and a boy with XYY sex chromosomes were both found to have a pericentric inversion of chromosome 9. An unusual feature of the XYY patient was that he presented because of short stature and disturbed behaviour. A family study showed that the patients were related and that there was ... | 699,364 | [
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Agonistic and antagonistic actions of 3,4-dihydroxy-substituted phenoxypropanolamines in guinea-pig atria and trachea. | 1. Racemic mixtures of noradrenaline, adrenaline, isoprenaline, N-t-butylnor-adrenaline and their corresponding derivatives containing an oxymethylene (OM) link between the phenyl ring and ethanolamine side-chain have been tested for their effects on beta-adrenoceptors in isolated guinea-pig atrial and tracheal prepara... | 699,383 | [
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Home treatment of uremia with gastrointestinal dialysis. | Twenty patients with end-stage renal disease and a creatinine clearance of less than 5 ml/min were tre ated with oral gastrointestinal (GI) dialysis. The dialyzate contained an electrolyte solution with 180-220mmoles/l of mannitol. In fasting state in the morning the self-prepared 7 liters of dialyzate was drunk at a ... | 699,395 | [
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Recurrent renal vein thrombosis consequent to membranous glomerulonephritis. | The diagnosis by inferior vena cavography of right renal vein thrombosis with extension into the vena cava was made in a 33 year old man with idiopathic membranous glomerulonephritis and multiple pulmonary emboli. After one year of continuous anticoagulant drug therapy with heparin and coumadin, venography showed absen... | 699,397 | [
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Radiation nephritis and intravascular coagulation. | A 23 year old male with embryonal cell carcinoma of the testicle was treated with radiation, receiving 2250 Rads to his abdomen twice, only once with kidney shielding. He developed acute renal failure approximately eleven months later. Associated with the renal failure were hemolytic anemia, thrombocytopenia, hypofibri... | 699,403 | [
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Pharmacokinetics of netilmicin in renal insufficiency and haemodialysis. | The pharmacokinetics of intravenously administered netilmicin, an investigational aminoglycoside antibiotic, were studied in 38 patients with creatinine clearance ranging from 150 to Oml/min/1.73m2 in order to determine the influence of kidney function status on the disposition of the antibiotic. The serum disappearanc... | 699,461 | [
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The malleability of infant motor development: cautions based on studies of child-rearing practices in Yucatan. | Tests with the Bayley Motor Scale were given to 288 infants, equally divided by sex, in Yucatan, Mexico. These were 2 to 54 weeks in age and came from three sociocultural levels. In comparison to USA infants, early acceleration of motor development was followed by a marked downward trend. This phenomenon, if observed i... | 699,470 | [
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Analytical subcellular fractionation of jejunal biopsy specimens: enzyme activities, organelle pathology and response to corticosteroids in patients with non-responsive coeliac disease. | 1. Jejunal biopsies from five patients with non-responsive coeliac disease have been subjected to analytical subcellular fractionation and enzymic microassay in order to compare the organelle pathology of this group with untreated but glutensensitive patients. 2. Compared with the gluten-sensitive group these non-respo... | 699,505 | [
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The distribution of cardiac output in the anaesthetized spontaneously hypertensive rat. | 1. Radioactive 15 micrometer and 50 micrometer diameter microspheres were used to determine cardiac output, its regional distribution and tissue blood flow in adult normotensive Wistar and Okamoto spontaneously hypertensive rats. 2. Cardiac output in the spontaneously hypertensive rats was the same as in Wistar normote... | 699,508 | [
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Promises, promises or community mental health services and training: ships that pass in the night. | In common with other publicly funded human-service programs, community mental health centers are victimized by a political advocacy process that inflates expectations, distorts value judgments and, as a result, helps promote ultimate disillusionment. The problems resulting from this "overpromise" are compounded by the ... | 699,532 | [
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Models of staff support for mental health/mental retardation community boards. | With the advent of the 1975 Amendments to federal mental health legislation which call for community governing bodies to oversee local mental health services, the question of effective board functioning becomes crucial. This paper describes professional staff roles and staff support models that can be used to enable be... | 699,533 | [
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Clinical interest of coronal and sagittal CT sections. | Normal and pathological anatomy of the brain can be studied in different cross-sectional planes. Of specific interest here are sagittal and coronal views obtained by computer reconstruction procedures. The three different planes for the reconstruction of the images are complementary, of real clinical interest, and are ... | 699,541 | [
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Clinical symptomatology and computerized tomography in brain metastasis. | In 50 patients with a diagnosis of brain metastasis, a study was made commencing with the appearance of the first neurological symptom. Severe headaches were observed in 48% of the patients, followed by a change in character in 11% and motor disorders in 11%. The search for initial neurological signs will help dictate ... | 699,546 | [
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Sensitivity and specificity of radioisotope renography in renovascular hypertension. | Effective drug therapy for hypertension modifies the urgency of establishing a diagnosis of renal arterial stenosis. The cost of establishing a diagnosis must be considered with other factors in determining the usefulness of renography in renovascular hypertension. Recently published studies estimate the cost effective... | 699,574 | [
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Renal secretion of inactive renin. | Human plasma contains a non-dialyzable factor which is not enzymatically active in its native form but shows renin-like activity after exposure to low pH (inactive renin). In 3 out of 13 patients with renovascular hypertension the renal to peripheral vein ratio for inactive renin on the affected side was above 1.40, in... | 699,585 | [
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Ethnicity and patterns of help-seeking. | This study reconstructs and analyzes pathways of help-seeking traveled by severely disabled mental patients in the community. Ethnicity is a prime factor in differentiating patterns of help-seeking in that Chinese patients are kept for prolonged periods of time within their families in the beginning of pathways, while ... | 699,621 | [
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... |
Combined antiviral effect of DNA inhibitors on adenovirus multiplication. | 9 purine or pyrimidine analogues or other inhibitors of DNA synthesis were studied on their single and combined inhibitory effect on the multiplication of adenovirus 9--15 in HeLa cell cultures. The criterium of inhibition was the total suppression of the formation of infectious virus. Inhibiting concentrations were de... | 699,675 | [
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Giardiasis and intestinal malabsorption: Report of a case. | The possibility of giardiasis should be considered in any case in which the patient has watery diarrhea and malabsorption syndrome. Investigation should include examination of at least three separate fecal specimens for Giardia lamblis. In case of negative results, this examination should be followed by aspiration of d... | 699,730 | [
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... |
Dissolution of Barium-impaction ileus by Gastrografin. | Ileus caused by impaction of hardened residual barium stagnated in the colon-a rare complication of barium-meal examination-constitutes a particularly serious problem when it occurs following abdominal operations, leading to postoperative ileus. The administration of Gastrografin in such cases has proven efficacy in th... | 699,741 | [
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0.1701958,
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Leiomyosarcoma of the rectum: report of three cases. | Three cases of leiomyosarcoma of the rectum are reported. The first patient underwent palliative surgery and died 18 months after diagnosis; local radiotherapy was not effective and chemotherapy failed as well. The second patient underwent radical surgical treatment but monetheless the tumor recurred and the patient di... | 699,743 | [
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[Significance of spontaneous and evoked temperature changes in the brain in applying the thermoclearance technic to the determination of cerebral blood flow]. | The authors carried out studies on cats under urethane narcosis and found that the presence of spontaneous temperature changes in two neighbouring regions of the cerebral cortex, were discovered at a distance of 5 mm from each other in a parallel course. After administration of pharmacological agents such as papaverine... | 699,870 | [
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Spectral properties of chlorophyll a monolayers in the presence of an exogenous electron donor and acceptor. | Chlorophyll a monolayers are studied at a nitrogen-water interface in the presence of a reducing or oxidizing agent: sodium ascorbate and benzyl viologen, respectively. Absorption spectra of the films are measured directly on the aqueous surface. With the aid of a computer, fourth derivative and difference spectra are ... | 699,913 | [
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Intravenous and oral practolol in the acute stages of myocardial infarction. | The influence of routine administration of the beta adrenoceptor blocking drug practolol on the outcome of acute myocardial infarction has been studied in 94 patients. The study was restricted to patients under the age of 70 experiencing their first myocardial infarction and in whom there was no contraindication to bet... | 699,938 | [
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... |
Congenital apical aneurysm of the left ventricle: surgical removal in two infants. | The case histories are described of 2 infants, representing either type of congenital apical left ventricular aneurysm. Case 1 had a finger-like, pulsatile, actively contracting aneurysm which was associated with a split distal end of the sternum and a ventral hernia. In contrast to most of the 55--60 cases hitherto de... | 699,941 | [
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Anomalous origin of the right coronary artery from the main pulmonary artery. | A case of anomalous origin of the right coronary artery from the main pulmonary artery, in a previously asymptomatic young woman, is presented. Direct transposition into the aortic root of the anomalous vessel was performed. To our knowledge this is the 4th case of this malformation to be successfully corrected. | 699,943 | [
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Intrathymic pathogenesis of myasthenia gravis: transient expression of acetylcholine receptors on thymus-derived myogenic cells. | Differentiation of myogenic stem cells from undifferentiated thymic stem cells is thought to play a critical role in the pathogenesis of myasthenia gravis. The expression of membrane acetylcholine receptor (AChR) on the membranes of developing muscle clones in cultures of murine thymus reticulum was followed and found ... | 699,955 | [
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The role of calcium in supersensitivity to the inotropic effects of norepinephrine. | Experiments using electrically stimulated rabbit left atria have demonstrated that supersensitivity to the inotropic effects of norepinephrine can be induced by either chronic reserpine pretreatment or hypothermia (lowering the temperature of the bathing medium). These two experimental conditions for inducing supersens... | 699,962 | [
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0.1224544,
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Responses of central neurones to piribedil and 2-bromo-alpha-ergocryptine: comparison with dopamine and apomorphine. | The effects of two putative dopamine receptor agonists, piribedil and 2-bromo-alpha-ergocryptine were studied by means of microiontophoresis. Their effects were compared with those of dopamine and apomorphine on neurones of the frontal cortex and of the caudate nucleus both of which are rich in dopaminergic terminals. ... | 699,972 | [
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... |
Effects of cold or restraint on incidence of gastric ulceration induced in rats by ulcerogenic drugs. | Exposure to cold (4degreesC) or restraint increased the incidence and severity of gastric ulceration induced after i.p. injection of phenylbutazone, aspirin and indomethacin but not of histamine. Oral administration of cimetidine, an H2-receptor blocker, 30 min before drug injection, prevented the occurrence of gastric... | 699,974 | [
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Transient effect of intracellular dantrolene on E--C coupling in skeletal muscle. | The effect of dantrolene-Na (DAN) on electrical and mechanical responses was investigated to single fibers of frog semitendinosus. Twitch tension was potentiated over 2--4 min by intracellular application of DAN and was rapidly decreased thereafter. Extracellular DAN depressed the tension with all dosages used. Althoug... | 699,975 | [
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... |
Microbiological oxidation of the pentyl side chain of cannabinoids. | Syncephalastrum racemosum ATCC 18192 and Mycobacterium rhodochrous ATCC 19067 partially degrade the n-pentyl side chain of cannabidiol, cannabinol, delta8-tetrahydrocannabinol and delta9-tetrahydrocannabinol. Carboxylic acid and alcohol side chain derivatives are major metabolites. | 700,011 | [
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Current(I)-voltage(V) relationships of the neuromembrane of an identifiable giant neurone of an African giant snail (Achatina fulica Férussac) in the presence of an inhibitory tripeptide, L-Lys-L-Phe-L-Tyr. | An inhibitory tripeptide, L-Lys-L-Phe-L-Tyr, caused membrane hyperpolarization of the TAN (tonically autoactive neurone) resulting in an elevated firing level. The tripeptide, however, did not markedly affect either the TAN I-V curve or the firing pattern obtained by transmembrane triangular current injection. | 700,024 | [
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Changes in cellular noradrenaline fluorescence in the denervated rat superior cervical ganglion. | The microfluorimetrical investigation showed that in the principal perikarya of the rat superior cervical ganglion, after inhibition of noradrenaline-synthesis and unilateral preganglionic axotomy, the fluorescence of newly synthesized noradrenaline was most intense at the periphery of the perikarya of the intact side. | 700,033 | [
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Family therapy and drug abuse: a national survey. | The following report describes the results of a national study of the role of family therapy in the drug abuse field. Characteristics of agencies that work with families are described, as well as the demographic characteristics and psychological problems of the clients most apt to be treated in family therapy. The stud... | 700,066 | [
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Some notes on the use of family sculpture in therapy. | Therapists learning to use family sculpture as a tool often find difficulty in exploiting the technique to its fullest. This article, designed to encourage therapists to take the risks involved in using a technique new to them, describes how the author and his cotherapists used sculpture in three cases in different way... | 700,071 | [
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How many children do couples really want? | Program workers and policy makers may be seriously misled if they put too great a reliance on statements about preferred family size. Underlying biases toward more or fewer children than the stated number affect the timing and effectiveness of contraceptive practice, and may help explain discrepancies between desired a... | 700,065 | [
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0.02909... |
[Pharmacology of calenduloside B, a new triterpene glycoside from the roots of Calendula officinalis]. | Calendulozide B--trioside of oleanolic acid, isolated from rhizomes of Calendula officinalis, Fam. Compositae, used perorally in doses of 5, 10, 20 and 50 mg/kg exerted an antiulcerous action in 3 experimental ulcer models of different genesis (caffein-arsenic, butadion and induced by ligation of pylorus) and also disp... | 700,077 | [
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0.1151... |
[Resistance to hypoglycemic sulfanilamides and biguanidines and its immune genesis]. | In blood of patients with diabetes mellitus receiving bucarban or adebit antibodies to these drugs were discovered. Patients medicated with bucarban demonstrated an elevated content of antibodies to insulin. The appearance of specific antibodies occurred in rabbits and rats following introduction of bucarban, glucophag... | 700,085 | [
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0.01212031,
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0.01850517,
0... |
[Effect of quinolaline di-N-oxide derivatives on the DNAse and plasmocoagulase of Staphylococcus aureus]. | The effect of the di-N-oxide quinoxaline on the activity and biosynthesis of DNA-ase and plasmocoagulating properties of the Staphylococcus aureus, strain Zhaev, was studied. The highest action in respect to DNA-ase of the Staphylococcus is shown to display dioxydine (1,4-di-N-oxide of 2,3-dioxymethylquinoxaline). Unde... | 700,089 | [
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... |
Relationship between vitamin K-dependent carboxylation and vitamin K epoxidation. | It has been postulated that the liver microsomal conversion of vitamin K hydroquinone to its 2,3-epoxide (epoxidase activity) is coupled in some obligatory fashion to the vitamin K-dependent carboxylation (carboxylase activity) event also occurring in microsomes. This hypothesis is supported by the observations that th... | 700,169 | [
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0.327201,
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The interaction of migration, income, and employment in Sweden. | A common approach in migration studies is to explain interregional migration by single-equation models. Such models are likely to suffer from simultaneous-equation bias when used in studies attempting to analyze migration over a long period of time. In this study, a simultaneous-equation appraoch is applied, which tak... | 700,223 | [
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Replication of mouse mammary tumor cells in monolayer cultures stimulated with embryo extract. | A particulate fraction derived from homogenized chicken embryos was added to primary monolayer cultures of mouse mammary tumor cells. All culture media contained fetal calf serum (10%). After 4 days, the extract had stimulated a twofold increase (relative to controls lacking the extract) in (1) total DNA per culture; (... | 700,243 | [
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0.3317992,
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0.009126024,
-0.292384... |
Osteopenia in insulin treated diabetes mellitus. Its relation to age at onset, sex and duration of disease. | Bone mineral content was measured by photon absorptiometry in 215 insulin treated diabetic out-patients aged 7--70 years. As bone mass increases until the age of 20--25 years, patients were so selected that all remained within the same phase of bone mineral storage throughout the entire course of their diabetes. Other ... | 700,276 | [
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0.185789,
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... |
Pilot study of self-measurement of blood glucose using the Dextrostix-Eyetone system for juvenile-onset diabetes. | Self-measurement of blood glucose was performed by eight insulin-dependent juvenile-onset diabetics. The patients were well motivated and improved control of diabetes was obtained. The method would seem to be useful for juvenile-onset diabetics, especially of the unstable type and for pregnant diabetics. | 700,277 | [
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... |
Somatotrophic diabetes: insulin release responses to arginine and glucagon in dogs. | Growth hormone injected daily in 6 dogs for 6 days caused a 20-fold elevation in fasting serum immunoreactive insulin (IRI) without appreciable change in serum glucose in 1 day. In the somatotrophic diabetes that occurred after 2 days, the hyperinsulinaemia was maintained and the serum IRI/glucose (I/G) ratio declined ... | 700,282 | [
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0.3029854,
0.3003012,
0.2244361,
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[Doppler echocardiography in the diagnosis of tricuspid anomalies (author's transl)]. | Doppler echocardiography has been applied in a study of the tricuspid and central venous blood velocity curves in a number of cases, including eleven cases of insufficiency, six cases of stenosis, five cases of steno-insufficiency of the tricuspid valve and one case of Ebstein's disease. The tracings were compared to n... | 700,300 | [
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-0.07787892,
... |
Immune responses in human colon cancer. I. Microcytotoxicity assay for measuring killing of adherent human colon cancer cell lines. | A short term microcytotoxicity assay system using radioisotope release as an index of target cell damage has been developed to evaluate immune killing of cultured adherent human colon cancer cell lines. Using this assay system, complement-dependent cytotoxicity, antibody-dependent cell-mediated cytotoxicity, and sponta... | 700,323 | [
-0.2577353,
-0.1358629,
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0.07762002,
0.1559434,
0.02908133,
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0.484839,
0.03226328,
0.1471326,
0.1166166,
0.1097216,
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0.2673374,
0.09692557,
0.3687017,
0.5920846,
0.1188424,
0.02261095,
0... |
[Desire for therapeutic abortion in the dependents of foreign workers. Outpatients psychiatric evaluation (author's transl)]. | The change in paragraph 218 of the criminal code regarding abortion was responsible for new guidelines for the psychiatric evaluation regarding a therapeutic abortion is reported. The commonest indications were medical reasons such as exhaustion, and reactive depression. There was one case of schizophrenia, one case of... | 700,347 | [
-0.191966,
0.5335668,
0.2183079,
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0.335873,
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0.002165515,
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0.1024352,
0.3831098,
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0.09372446,
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0.004481055,
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0.1682728,
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0.2520265,
-0.1729558,
0.476196,
-0.1634301,
0.... |
Changes in the relative amount of surface antigens on the living cells after treatment with insoluble protease derivatives. | Relative amount of surface antigen was compared on L 1210 leukaemia cells treated with soluble or insoluble derivatives of trypsin and papain. Trypsin or trypsin insoluble derivative do not change the amount of antigen significantly as compared with control. However, papain insoluble derivative decrease the relative am... | 700,504 | [
-0.07159166,
0.0320008,
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0.03432005,
0.1159307,
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0.390142,
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0.3066072,
0.3279669,
0.1435742,
-0.2811324,
... |
[Action of 4-amino-alpha-](tertbutylamino) methyl]-3, 5-dichlorobenzylalchol hydrochloride (N-AB 365, clenbuterol) on the respiratory system (author's transl)]. | The bronchodilating effect and other related pharmacological properties of N-AB 365 were studied in comparison with those of isoproterenol, salbutamol and clorprenaline. N-AB 365 was found to produce a bronchodilating effect 1/20 approximately 1/100, 1/10 approximately 1/40 and was 2 to 5 times as strong as effects of ... | 700,519 | [
-0.06478731,
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0.1776254,
0.03551734,
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0.1300289,
0.08836038,
0.5196607,
0.2633933,
0.1842074,
-0.04658808,
... |
Microcycle sporulation in the Claviceps purpurea 244. | The mutant strain Claviceps purpurea 244 forming hyphae composed mainly from sclerotium-like cells was found to sporulate both in liquid and solid media, particularly in the form of terminal chlamydospores (4.0 x 6.5 micrometer). Chlamydospores produced during submerged cultivation germinated, new chlamydospores being ... | 700,525 | [
0.0004300575,
0.0780516,
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0.08905759,
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0.08939709,
0.004730088,
0.3060251,
0.7155538,
0.4509275,
0.1287913,
-0.... |
[Polymyalgia arteriitica]. | A description of the polymyalgia arteriitica is presented: preference of beginning in higher age, leading symptom being muscular pain at the back of the neck, around the shoulders, the upper arms, the buttocks and thighs as well as the visibly augmented erythrocyte sedimentation rate. The arteriitic manifestation being... | 700,564 | [
-0.02533795,
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0.3821357,
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0.003154294,
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0.1237938,
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0.1010313,
0.5851333,
0.5076459,
0.02504298,
-0.03606358,... |
Community residential treatment for schizophrenia: two-year follow-up. | Two-year outcome data from a study comparing two kinds of treatment given similar groups of young, newly diagnosed, unmarried schizophrenic patients deemed in need of hospitalization are reported. The experimental program, Soteria, is a nonmedical, psychosocial program with minimal use of antipsychotic drugs; it is sta... | 700,610 | [
-0.2399624,
0.3684475,
0.07091099,
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0.1718195,
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0.0366469,
0.0138833,
0.07971424,
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0.08389757,
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0.007747,
0.2189243,
-0.1137653,
-0.05883761,
-0.2560464,
0.1781578,
-0.00399529... |
Anatomic and chromosomal anomalies in 944 induced abortuses. | A total of 944 induced abortuses, 922 of which apparently were anatomically normal and 22 of which were anatomically abnormal, were set up in culture. Of these abortuses, 910 (96.4%) were successfully karyotyped. The study can be divided into two periods. In the initial period, specimens without recovered fetal tissues... | 700,699 | [
-0.03365786,
0.1593893,
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0.3692348,
0.3953976,
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0.01971255,
0.111424,
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0.1384657,
0.2419288,
-0.04267433,
0.2002652,
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-0.4456097,
0.03959558,
-0.009895572,
-0.2052757,
0.2097089,
0.4266589,
-0.3573333... |
Growth rhythms of the cartilage of the mandibular condyle: effects of orthopaedic appliances. | The growth rate of the cartilage of the mandibular condyle in the young rat exhibits: - a circadian cycle with a maximum of the 3H-thymidine labelled cells around 13(00) and a minimum around 01(00); with a maximum in the number of mitoses around 21(00) and a minimum around 09(00). - a circannual cycle with a maximum in... | 700,904 | [
-0.1818825,
0.1488391,
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-0.4279359,
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0.0843363,
-0.09784976,
-0.03994866,
-0.059169,
-0.01789069,
-0.0229467,
-0.173308,
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0.05025347,
0.03105626,
0.05400189,
-0.1213455,
0.01635911,
0.1570779,
-0.3047557,
0.07070792,... |
Dose equations without protein-binding parameters. | Simple and practical dose equations for oral administration and intravenous infusion are derived by means of pharmacokinetics. These equations have no troublesome parameters for adsorption of drug on protein in blood, as these are eliminated with the help of information obtained by the pilot dosing. | 700,909 | [
-0.2389517,
-0.1090207,
-0.01871496,
-0.09728502,
0.2427381,
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0.04808175,
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0.06579041,
0.08158486,
0.07032756,
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-0.4145439,
0.04531394,
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0.2676263,
0.05879066,
0.108131,
0.1841168... |
Carcinogens and analogs: trace analysis of thirteen compounds in admixture in wastewater and human urine. | A gas chromatographic method is described for determining traces of 13 carcinogens and related compounds (aromatic amines and estrogens) in admixture in wastewater and human urine. This method was developed for use in toxicological research for monitoring the safe disposal of wastewater and to signal any accidental exp... | 700,918 | [
-0.2257656,
0.4081991,
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-0.1215297,
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0.1648298,
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0.465142,
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-0.2089868,
0.2719685,
0.2517108,
0.1865094,
0.1493025,
0.1786505,
-0.1985933,
... |
Evaluating liaison program effectiveness: the use of unobtrusive measurement. | The author suggests that the goal of liaison psychiatry as well as its organizational and clinical properties require the use of measures which are non-reactive and developmental in nature. In this paper four categories are theorized as representing the implicit working assumptions of nonpsychiatric housestaff in clini... | 700,927 | [
-0.2642545,
0.398064,
0.202039,
-0.2826707,
0.05365073,
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0.03675342,
0.1278164,
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0.1312672,
0.03691179,
0.2603552,
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0.1852228,
-0.3676655,
0.2368494,
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-0.02786698,
0.1636497,
0.1271245,
0.04809207,
-0... |
Esophageal reflux after gastrectomy: a hazard after Billroth-I subtotal gastrectomy. | One hundred and seventy-six patients were evaluated for esophageal reflux after gastrectomy. Apart from proximally and totally gastrectomized cases, the conventional Billroth-I type of distal subtotal gastrectomy destroys many esophageal reflux preventive mechanisms. The Roux-en-Y type of repair should be adopted for t... | 700,935 | [
-0.00122798,
-0.02774515,
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0.2746641,
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0.1365049,
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0.05428801,
0.2868714,
0.3232554,
0.06758346,
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-0.223648,
0.1700691,
0.07997376,
-0.09448498,
0.239261,
0.3511789,
0.02306638,
... |
Treatment of testicular hypofunction with gonadotrophic hormones. | The paper reports on the response to gonadotrophic hormone treatment in cases of male infertility. The report includes 119 cases treated between 1971 and 1975. The evaluation of the results of gonadotrophic hormone treatment led to the following conclusions. Treatment with Praedyn has been relatively successful and the... | 700,942 | [
0.2720478,
0.2302804,
-0.4306752,
0.08634305,
0.2662133,
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0.09641138,
0.007146397,
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0.1281503,
0.1260414,
0.1438656,
-0.06308199,
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0.01130067,
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0.06446502,
-0.1057829,
0.1742749,
0.2804229,
0.1674293,
-0.0859343,
-... |
Effects of 1alpha-hydroxyvitamin D3 on serum calcium and immunoreactive parathyroid hormone in patients with chronic renal insufficiency. | Six patients with chronic renal failure on regular dialysis treatment were given low doses (0.5--1.0 microgram/day) of 1alpha-hydroxyvitamin D3, monitoring the serum calcium, inorganic phosphate, immunoreactive parathyroid hormone concentration (IPTH) and alkaline phosphatase activity. The serum calcium rose in all pat... | 700,946 | [
-0.3331884,
0.01624978,
-0.2491362,
-0.2086058,
0.2723792,
-0.1529198,
-0.0187253,
0.1669998,
0.05824508,
0.01471722,
0.1514731,
0.3042953,
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-0.02617873,
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0.3125727,
0.09643324,
0.3008603,
0.1904033,
0.5795678,
-0.1615388,
0.1... |
Monochromatic (red-free) photography and ophthalmoscopy of the peripapillary retinal nerve fiber layer. | The appearance of the peripapillary retinal nerve fiber layer (PRNFL) is crucial in the evaluation of patients with presumed optic neuropathies as well as in the differentiation of true optic disc edema from pseudopapilledema. Monochromatic (red-free) photography performed at 2 + magnification with a Zeiss fundus camer... | 700,962 | [
0.04762133,
-0.009764239,
-0.194789,
-0.02190104,
-0.1980063,
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0.5487065,
-0.02042188,
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0.05364334,
0.1776137,
-0.02963478,
0.1988357,
-0.1642692,
-0.2742075,
-0.318483,
-0.1846506,
0.07263388,
-0.1825269,
-0.1199887,
0.2036776,
0.1043155,
-0.07562... |
Electroretinography with noncorneal and corneal electrodes. | The noncorneal ERG is essential for certain patients in which corneal recording is contraindicated. A preliminary report is presented investigating ERGs from three noncorneal montages and their correlation with the corneal ERG. Statistical analysis showed that an electrode at the medial canthus combined with medial vie... | 700,963 | [
-0.1822722,
0.084846,
-0.3465543,
-0.2792914,
0.09420974,
-0.2224205,
-0.1877753,
-0.2446893,
0.1570309,
0.01431315,
-0.1679604,
0.04946499,
0.07534689,
0.2580137,
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0.002412501,
-0.160958,
0.2676049,
-0.3072316,
-0.03673889,
0.1087498,
-0.03755799,
0.4071831,
... |
Instrumented measurement of human joint motion. | Accurate measurement of human joint motion is essential to the design and evaluation of internal joint prostheses and artificial limb replacements. A triaxial electrogoniometer instrumented by three miniature precision potentiometers was developed to fulfill this task. A special linkage was used to attach this apparatu... | 700,993 | [
-0.02683622,
0.3814705,
-0.2591403,
0.3647221,
0.09834074,
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0.472048,
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-0.02934515,
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0.1228881,
-0.4332492,
-0.4189871,
0.1289468,
-0.3475538,
0.147705,
-0.6584344,
-0.3201612,
0.2521407,
-0.1193795,
0.2464035,
... |
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