title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Congenital QT interval prolongation. A review with a survey of three families. | The prolonged QT interval syndrome without hearing loss (Romano-Ward syndrome) is described in three families with 48 affected members. Syncope or dizziness caused by different ventricular tachyarrhythmias were the presenting symptoms in the symptomatic patients. Four of the subjects died suddenly. Right stellate gangl... | 700,996 | [
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Hemoglobin H disease in Sardinia: phenotypic and genetic observations. | In this study the clinical and hematological characteristics, the transmission pattern and the relative rates of globin chain synthesis were determined in the members of four Sardinian families with 14 patients affected by hemoglobin H disease. The severity of hemoglobin H disease in Sardinian subjects shows a high deg... | 701,089 | [
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Effects of angiotensin antagonism at rest and during exercise in sodium-deplete man. | Mean intra-arterial pressure (P-), heart rate (HR), cardiac index (CI), total peripheral resistance index (TPRI), and plasma renin activity (PRA), norepinephrine (PNE), and epinephrine (PE) were estimated in five normal male subjects placed on a low-sodium diet for the previous 7 days. Subjects were studied during rest... | 701,125 | [
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Management of some complications of the medallion circular loop lens. | Iris damage in the area with loop contact can be prevented by lowering the dosage of steroids. An already damaged iris can be saved with phospholine iodide followed by phospholine iodide combined with atropine to immobilize the iris. On a low dose keratic precipitate-like spots will be formed on the pseudophakos, but t... | 701,142 | [
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Comparison of titanium loop and supramid loop lens implants: 100 patients. | One-hundred patients having intracapsular cataract extraction with intraocular lens implantation are compared with 139 patients having routine intracapsular cataract extraction. All patients were operated on by one surgeon, utilizing one technique, and, where implantation was performed, utilizing one style of lens from... | 701,171 | [
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A quantitative study of peripheral nerve fibres in the mouse following the administration of drugs. 1. Age changes in untreated CBA mice from 3 to 21 months of age. | This study is concerned with the quantification of changes which occur in peripheral nerves of normal mice from the onset of maturity to old age. The parameters chosen were total fibre area and axon area. Size distributions of these were expressed in the form of histograms. From the area data notional fibre and axon di... | 701,188 | [
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The effect of position on the migration of muscle. | The tibial insertion of the M. semitendinosus of young rabbits was moved to a new location on the shaft of the tibia, either 5 or 10 mm proximal, or 0, 10, 20, 30, 40, or 50 mm distal to its original position. The animals were killed 8.5 months later. The results show that the greatest amount of proximal migration of t... | 701,193 | [
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Carbon monoxide binding to a fish hemoglobin under photostationary conditions. | Determinations of carbon monoxide binding curves for hemoglobin from Brevoortia tyrannus under equilibrium and photostationary conditions show that in the light, the curve is shifted to the right and altered in shape. The Bohr effect is much less in the light. The kinetics of the transition between equilibrium and phot... | 701,255 | [
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Isolation of monomeric cytochrome f from Japanese radish and a mechanism of autoreduction. | Monomeric cytochrome f from Japanese radish (Raphanus sativus L. var acanthiformis Makino) leaves was isolated in a homogeneous state with an A420.5/A277 of 7.6. Radish cytochrome f is a single polypeptide chain with a molecular weight of about 33,000. The midpoint potential is 350 mV. The amino acid analysis indicates... | 701,259 | [
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Characterization of intermediate hemoglobin produced during methemoglobin reduction by ascorbic acid. | Methemoglobin reduction by ascorbic acid was found apparently to cease halfway without further reduction. Studies by isoelectric focusing on Ampholine plate gel revealed that the solutions of the halfway reduced methemoglobin are composed of about 6% oxyhemoglobin, 59% intermediate hemoglobin, and 35% methemoglobin. Th... | 701,262 | [
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Peroxisomal localization of serine:pyruvate aminotransferase in human liver. | The distribution of L-serine:pyruvate aminotransferase (EC 2.6.1.51) in human liver was examined by centrifugation in a sucrose density gradient. The enzyme was located only in the peroxisomes and in the soluble fraction. The peroxisomal and soluble enzymes were highly purified and characterized. The two enzyme prepara... | 701,275 | [
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Inhibition of elongation steps of protein synthesis at reduced potassium concentrations in reticulocytes and reticulocyte lysate. | We treated intact reticulocytes with nystatin to make them permeable to small cations and varied the concentration of K+ in the medium; the ionic strength was kept constant by adjusting Na+. As the intracellular K+ was lowered, the rate of protein synthesis decreased. In a reticulocyte lysate, the dependence of the rat... | 701,288 | [
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Arthrodesis in failed total knee replacement. | Compression arthrodesis can be used as a salvage procedure in failed total knee replacement. In fourteen patients so treated, the fusion failed in five. As regards the cause of failure, the most important factor was technical inadequacy of the arthrodesis procedure; that is, the required stable fixation and solid bone-... | 701,312 | [
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Fractures of the odontoid process in young children. | We reviewed eleven patients less than seven years old with fractures of the odontoid process in an effort to establish a more standard form of treatment for the injury and to determine what complications, if any, occur as a result of fractures of the odontoid process in pediatric patients. Our study showed that childre... | 701,339 | [
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Segmental fractures of the femur treated by closed intramedullary nailing. | Twenty acute segmental fractures of the femoral shaft were treated with closed intramedullary nailing. The severity of the soft-tissue damage and associated injuries necessitated careful preoperative care. The surgical technique and means of reduction are outlined. Follow-up of at least one year on all patients showed ... | 701,342 | [
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Acute ulnar neuropathy with fractures at the wrist. | Injury to the ulnar nerve associated with or following a fracture at the wrist is unusual. Three cases of this association are presented. Previously reported cases have been reviewed. The associated lesions tend to occur in young adults after higher-energy trauma and more dorsal displacement of the distal radial fragme... | 701,345 | [
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Heterogeneous nuclear RNA-protein fibers in chromatin-depleted nuclei. | The heterogeneous nuclear RNA-protein (hnRNP) fibers in HeLa cell nuclei are visualized by a nuclear subfractionation technique which removes 96% of the chromatin in a single step and 99% in a two-step elution but leaves the bulk of the hnRNA complexed with the remnant nuclear structure or lamina. Both steady-state and... | 701,354 | [
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Membrane proteins synthesized but not processed by isolated maize chloroplasts. | One-dimensional maps of proteolytic fragments generated by digestion with Staphylococcus aureus protease in sodium dodecyl sulfate (SDS) were used to identify three polypeptides synthesized by isolated Zea mays chloroplasts. This technique does not depend upon proper incorporation of the newly synthesized polypeptides ... | 701,358 | [
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Nerve growth factor prevents the death and stimulates the neuronal differentiation of clonal PC12 pheochromocytoma cells in serum-free medium. | The PC12 clone is a noradrenergic cell line derived from a rat pheochromocytoma. In culture medium containing horse serum, PC12 cells undergo mitosis; when nerve growth factor (NGF) is included in the medium, the cells cease multiplication and extend neuritis. It is shown here: (a) that PC12 cells are not viable in ser... | 701,359 | [
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Spatial orientation of glycoproteins in membranes of rat liver rough microsomes. I. Localization of lectin-binding sites in microsomal membranes. | Carbohydrate-containing structures in rat liver rough microsomes (RM) were localized and characterized using iodinated lectins of defined specificity. Binding of [125I]Con A increased six- to sevenfold in the presence of low DOC (0.04--0.05%) which opens the vesicles and allows the penetration of the lectins. On the ot... | 701,363 | [
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Physiological and morphological evidence for coupling in mouse salivary gland acinar cells. | Three experimental techniques were employed to examine coupling between acinar cells of the mouse salivary gland. Passage of DC current pulses via intracellular microelectrodes between neighboring cells showed that small ions could be directly passed from one cell to another. Intracellular iontophoresis of the dye Luci... | 701,371 | [
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Inhibition of sugar uptake in adenosine-treated 3T3 cells. | Addition of 5 to 250 micromolar adenosine to the culture medium resulted in a 30-80% inhibition of the rate of uptake of 2-deoxyglucose or 3-0-methylglucose by sparse or confluent 3T3 cells within three hours. The inhibition of deoxyglucose uptake could be reversed partially by changing the cells to medium without aden... | 701,388 | [
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The osmotic properties of the acrosome of guinea-pig sperm. | The osmotic behaviour of the acrosome in intact guinea-pig sperm has been examined by light and electron microscopy. Because the acrosome is retained within the cell, it can only experience the changes in tonicity of the cytoplasm and these have first to be related to the changes in tonicity in the external medium. Nev... | 701,392 | [
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Developmental stages in the formation of inverted gap junctions during turnover in the adult horseshoe crab, Limulus. | Stages leading to the formation of inverted gap junctions between certain basal replacement or interstitial cells in the mid-gut of adult Limulus can be followed by freeze-fracturing. Free, 13-nm EF intramembranous particles first appear to be organized into short linear arrays or small clusters of particles, which the... | 701,397 | [
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Invasive locomotory behaviour between malignant human melanoma cells and normal fibroblasts filmed in vitro. | Explants of human malignant melanoma (MM96), normal adult human skin fibroblasts (HSF) and embryonic chick ventricle were confronted in pairs. The 2 outwandering populations in each confrontation eventually met in a situation where each could potentially invade the other. The human explants were artificially prepared f... | 701,403 | [
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Selecting somatic cell hybrids with hat media and nystatin methyl ester. | The structurally modified polyene antibiotic nystatin methyl ester (NME) has been utilized as a half-selection agent for isolating interspecific mouse--Syrian hamster hybrids. By using HAT media supplmented with NME we have isolated hybrid clones from polyethylene glycol-fused cultures of biochemically defective mouse ... | 701,404 | [
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[Bony tumors of the thoracic wall. Report of 35 cases (author's transl)]. | The authors report 35 cases of bony tumours of the thoracic wall and emphasize:--the necessity of wide removal even in the case of benign tumours to avoid possible relapses;--the use of rigid material which in the case of anterior parietal breaches, is alone able to give satisfactory solidity to the thoracic wall which... | 701,411 | [
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Automated quantitative gas--liquid chromatography of intact lipids. I. Preparation and calibration of the column. | A method for quantitative gas chromatographic determination of plasma lipids (free cholesterol, cholesteryl esters and triglycerides) in the low concentration range is described. This method permits a determination of not only the lipid classes mentioned above, but also their fractions according to molecular weight, do... | 701,423 | [
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0.3170161,
0.1744455,
0.01074458,
-0.4019709,
... |
Assay of pemoline in human plasma, saliva and urine by capillary gas chromatography with nitrogen-selective detection. | A simple gas chromatographic assay of the psycho-stimulant pemoline in human urine, plasma and saliva has been developed. Instead of direct extraction of the drug from urine, plasma and saliva, it is hydrolyzed to 5-phenyl-2,4-oxazolidine-dione with 1 N hydrochloric acid. After extraction this compound is methylated wi... | 701,438 | [
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Role of large arteries in regulation of cerebral blood flow in dogs. | Previous studies have demonstrated a significant pressure gradient from carotid artery to pial or middle cerebral arteries. This pressure gradient suggests that large cerebral arteries contribute to cerebral resistance. We have tested the hypothesis that large cerebral arteries contribute to regulation of cerebral bloo... | 701,475 | [
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Decreased insulin sensitivity of forearm muscle in myotonic dystrophy. | Previous studies of patients with myotonic dystrophy have demonstrated hyperinsulinism after glucose loading. This hyperinsulinism has been attributed by some investigators to tissue insulin resistance. We have directly studied insulin sensitivity of forearm muscle in patients having such hyperinsulinism. The effect of... | 701,484 | [
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Absence of thoracic osteophytosis in the area adjacent to the aorta: computed tomography demonstration. | Computed tomography of the chest shows that right-sided unilateral thoracic osteophytosis is a common phenomenon. The cross-sectional images obtained appear to support the thesis that aortic pulsations have a preventive effect on the formation of left-sided osteophytes. | 701,503 | [
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Noise limitations in X-ray computed tomography. | A lower bound for the statistical accuracy in X-ray computed tomography, which, under certain conditions, is independent of the reconstruction algorithm, is derived. An evaluation of this bound indicates that little improvement is possible over the performance of the convolutional algorithm. | 701,527 | [
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Computed tomography of anatomic specimens. | To obtain high quality computed tomographic (CT) images of specimens, the specimens must be submerged in water and immobilized. We describe a simple, effective technique for imaging brain specimens in various CT scanners. Anatomic sections that correspond exactly to the plane of the CT image may be obtained | 701,531 | [
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Comparison between tail vein and jugular vein cannulation in cattle. | Blood samples obtained simultaneously from the jugular and tail (coccygeal) veins during induction of bovine mastitis infection and after administration of 250 IU of adrenocorticotropin did not differ in percentage of hematocrit, concentration of total corticosteroid in plasma, or concentrations of total circulating er... | 701,538 | [
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Fluorescent lighting: a purported source of hyperactive behavior. | Seven first-grade children with conduct disorders and/or hyperactivity attended full-day sessions at a laboratory school classroom. During an 8-week period, the classroom lighting conditions alternated at the end of each week. During odd-numbered weeks, the classroom was illuminated by a standard cool-white fluorescent... | 701,640 | [
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Thermal destruction of folacin in microwave and conventional heating. | Folacin derivatives were found to vary greatly in thermal stability. It is worth mention that pteroylmonoglutamic acid (PGA), the folate used therapeutically and in food supplementation, was extremely stable to heat under the experimental conditions, that is, at 100 degrees C. in neutral solution. Under these condition... | 701,671 | [
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Problems in rehabilitation after age sixty-five. | Of 100 patients on the Rehabilitation Service of a general hospital (New England Memorial), 75 were past 65 years of age. In this age group, recovery from illness or an accident is longer and slower, with many more complications. Rehabilitation that accomplishes independence in daily-living skills is extremely importan... | 701,703 | [
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Maturational variations and genetic-dynamic issues. | Psychic issues may influence apparatus functioning, and thus may lead to maturational variations. However, in this papper I have emphasized the converse: the influence of maturational variations on psychic issues. I have singled out for discussion three areas of the originally autonomous sphere: perception, motility, a... | 701,734 | [
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[Tubal microsurgery: methodology (author's transl)]. | --A few assessments concerning general methodology of microsurgery and surgical repair of the Fallopian tubes are presented. --Some serials on the operating room setting-up are proposed on a practical point of view. --The value of the microsurgical approach is then reviewed for each particular technique of tuboplasty. | 701,746 | [
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Intraosseous wiring of the digital skeleton. | One hundred cases of osteosynthesis done by the use of intraosseous wiring are presented. Two techniques of wiring are described, one used in transverse fractures and arthrodeses in which an additional Kirschner wire is employed, the other in which No. 0 monofilament wire can be placed perpendicular to the line of oste... | 701,766 | [
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Myxomatosis: the occurrence of antibody to a soluble antigen of myxoma virus in wild rabbits, Oryctolagus cuniculus (L.), in Victoria, Australia. | The occurrence of antibody of myxoma virus in wild rabbits following epizootics is highest in the semi-arid north-west of Victoria and lowest in temperate southern Victoria. Occurrence ranges up to about 90% in the north-west and to about 70% in the south except on the Western Plains where epizootics are rare and antib... | 701,788 | [
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A survey of Nairobi sheep disease antibody in sheep and goats, wild ruminants and rodents within Kenya. | The distribution of antibody to Nairobi sheep disease in sheep and goats in Kenya was found to coincide closely with that of the tick, Rhipicephalus appendiculatus. The proportions of a population in an enzootic area with antibody was similar in the different age groups. No antibody to the virus was found in rodent ser... | 701,789 | [
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The safety of the Trexler isolator as judged by some physical and biological criteria: a report of experimental work at two centres. | We have assessed the effectiveness of flexible-film negative-pressure isolators by physical and biological means. We found that they afford a high degree of containment and therefore also of safety to hospital staff. We offer some recommendations on the operation of these isolators to ensure the optimum degree of prote... | 701,792 | [
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Phagocytosis of technetium-99m sulfur colloid by human polymorphonuclear leukocytes. | This study characterizes a new phagocytic assay system utilizing technetium-99m sulfur colloid as the phagocytic particle. Uptake of sulfur colloid by human polymorphonuclear leukocytes is a time and temperature dependent process that requires glucose for optimal uptake. In contrast to many other systems, sulfur colloi... | 701,815 | [
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The stability of vitamin A-induced metaplasia of mouse vibrissa follicles in vitro. | Tests were made of the stability of the previously described glandular morphogenesis and mucous metaplasia of embryonic mouse vibrissa follicles produced in vitro by excess vitamin A. The changes in individual follicles were observed in living tissue explants and serial sections. Upper lip skin of 13.5-day embryos unde... | 701,843 | [
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A rare case of malignant otitis externa in a non-diabetic patient. | A case of an elderly non-diabetic patient suffering from malignant otitis externa is reported. The organisms were resistant to Gentamicin and the cause of death was a sub-dural abscess causing pressure on the pons. | 701,982 | [
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Control of the acute phase response. Demonstration of C-reactive protein synthesis and secretion by hepatocytes during acute inflammation in the rabbit. | To determine the cell of origin of C-reactive protein (CRP) and to cast light on the mechanisms leading to the acute phase response, we used an immunoenzymatic technique to visualize this protein in livers from rabbits at intervals after intramuscular injection of turpentine. CRP was detected only in hepatocytes. 8 h a... | 702,046 | [
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The effect of complement on the ingestion of soluble antigen-antibody complexes and IgM aggregates by mouse peritoneal macrophages. | Complement was found to stimulate markedly the ingestion of soluble antigen-antibody complexes by mouse peritoneal macrophages. This was shown indirectly by measuring the release of degradation products when the complexes were labeled with 125I, or directly when the antigen, that was human transferrin, was labeled with... | 702,063 | [
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Exploring the doctor-patient relationship: a sociocultural pilot study in a family practice residency. | Family physicians' growing attention to the nature of their patients' live should include the social and cultural factors that influence patient health and illness behavior. Patient visits to a family practice residency program were found to be influenced by the patients' beliefs about symptoms and the beliefs of their... | 702,070 | [
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Obstetrics in family practice: a model for residency training. | Family physicians have a unique service to offer families at the time of their reproduction, and have a role to play that cannot be duplicated by an obstetrician-gynecologist or pediatrician. The process of a family integrating a new member is a natural concept to family practice and lends itself to a family-centered m... | 702,071 | [
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Toward the evaluation of family practice: development of a family utilization index. | This paper describes a research project that establishes criteria for utilization patterns of a family practice that could be used to develop evaluation techniques for family practice as a method of delivering primary medical care. The criteria are summarized in a Family Utilization Index, which measures the utilizati... | 702,075 | [
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Increase in concanavalin A binding sites in mouse blastocysts during implantation. | The number of concanavalin A (Con A) binding sites were determined in mouse blastocysts before and during implantation. In intact pregnant mice (Day 1 = day of finding vaginal plug), the Con A binding sites per blastocyst were increased from 169 million on Day 4 morning to 1160 million on Day 5 morning when implantatio... | 702,085 | [
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The effect of oxygen on the development of preimplantation mouse embryos in vitro. | The optimal oxygen tension for development of preimplantation mouse embryos to the blastocyst stage in vitro was found to be between 2.5% and 5%. One- and two-cell embryos had a more sharply defined range of oxygen tension capable of supporting development than 8-cell and morula stages. At all stages of development, mo... | 702,089 | [
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... |
Differences in sialic acid content of human interferons. | Human leucocyte, lymphoblastoid and fibroblast interferons were separately treated with sialidase and the effect of this on their isoelectric focusing was examined using a system in which full dissociation of complexes occurred. Both leucocyte and lymphoblastoid interferons showed a single form with an isoelectric poin... | 702,115 | [
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Cognitive and evoked response measures of information processing in schizophrenics with and without a family history of schizophrenia. | Twenty-four male schizophrenics, 12 (SFH) with schizophrenia in the immediate family and 12 (SNFH) with no evidence of schizophrenia in the family background, and 24 male control subjects, 12 highly educated (HEC), and 12 minimally educated (MEC), were assessed for premorbid social adjustment and were administered the ... | 702,129 | [
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0.3449748,
0.11059... |
A clinical study of chronic childhood spinal muscular atrophy. A review of 141 cases. | The case histories and clinical details of 141 children (67 males and 74 females) with chronic childhood spinal muscular atrophy (SMA) have been reviewed. Hundred of these children were alive at the time of the study. The cases comprise a consecutive unselected series of all with this disease who presented to two large... | 702,181 | [
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0.2933648,
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Effect of postweaning feed restriction on adipose cellularity and body compositon in polygenic obese mice. | The M16 line of mice, selected for rapid postweaning gain, exhibits polygenically controlled obesity and hyperphagia. The effect of limiting postweaning energy intake on the subsequent growth and development of obesity in M16 mice was investigated. Male mice from M16 and an unselected line (ICR) were provided either ad... | 702,208 | [
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... |
Revaccination of previous recipients of killed measles vaccine: clinical and immunologic studies. | Clinical and immunologic studies were performed in association with revaccination with live measles vaccine in 75 adolescents 11 to 14 years after immunization with killed measles vaccine. Ten subjects had local pain with swelling or erythema or both at the injection site; in three, the local reactions were severe and ... | 702,235 | [
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Randomized trial of early closure of symptomatic patent ductus arteriosus in small preterm infants. | As a result of randomized assignment, 15 preterm infants weighing 1,500 gm or less at birth and who had a symptomatic PDA were treated according to a medical management protocol, and ten according to an early surgical closure protocol. All infants required mechanical ventilation at the time of study entry, which was on... | 702,245 | [
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Surgical resection for pulmonary interstitial emphysema in the newborn infant. | Three patients with pulmonary interstitial emphysema are presented in whom the course was similar and progressive. Eventually all three infants developed respiratory insufficiency and chronic dependence on mechanical ventilation, cardiovascular complications of patent ductus arteriosus with congestive heart failure, an... | 702,247 | [
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Neonatal transport: a controlled study of skilled assistance. Mortality and morbidity of neonates less than 1.5 kg birth weight. | To attempt to demonstrate the need for skilled care of sick neonates in transport, a modified randomized controlled study of infants being transported to this institution was carried out. Although special equipment was used, ambulances were not modified. Results of the first phase reported here show that infants weighi... | 702,248 | [
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Pulmonary pressure/volume relationships during the last phase of delivery and the first postnatal breaths in human subjects. | Intrathoracic pressure and volume changes during delivery and the first postpartum breaths were measured in 17 term infants. The following findings emerged: (1) Infants were often exposed to high pressures during delivery, when significant volumes of lung fluid were expressed. (2) Despite this, none of the infants' lun... | 702,249 | [
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Progestin permeation through polymer membranes I: diffusion studies on plasma-soaked membranes. | The potential of several commercially available polymeric materials for use in controlled-release drug delivery devices was investigated. Progesterone was used as a model hydrophobic drug. The progesterone permeation rates through polydimethylsiloxane, two polyether urethanes, a hydroxyethyl methacrylate, a polyether u... | 702,276 | [
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Enhancement of bioavailability of a hydrophobic amine antimalarial by formulation with oleic acid in a soft gelatin capsule. | The relative availability of the orally administered hydrophobic antimalarial alpha-(dibutylaminomethyl)-6,8-dichloro-2-(3',4'-dichlorophenyl)-4-quinolinemethanol (I) from two dosage forms was determined in beagle dogs. Compound I was soluble in oleic acid to the extent of 23.5% (w/w), and oleic acid was suitable for e... | 702,283 | [
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Interactions of caffeine and theophylline with p-cresol: UV studies. | UV absorption studies demonstrated the formation of weakly bonded charge transfer complexes between caffeine and theophylline with p-cresol in chloroform. The transitions involved were detected at wavelengths longer than those of the single pure substances. Equilibrium constants from the Benesi-Hildebrand equation coul... | 702,285 | [
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Semiautomated system for high-pressure liquid chromatographic determination of dissolution rate of fludrocortisone acetate tablets. | A new semiautomated high-pressure liquid chromatographic (HPLC) system is described to determine the dissolution rate of fludrocortisone acetate tablets. The system uses a miniaturized dissolution basket and shaft assembly having the same geometry as that given in USP XIX. This reduced size permits use of smaller volum... | 702,288 | [
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0.027506... |
Simultaneous solubilization of steroid hormones I: estrogens and C21 steroids. | The simultaneous solubilization of some estrogens and C21 steroids in aqueous polysorbate 40, tetradecyltrimethylammonium bromide, and sodium lauryl sulfate was studied. The less soluble estrogen estradiol was solubilized independently of the C21 steroids. The micellar solubilities of ethinyl estradiol and both cortico... | 702,293 | [
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0.1298603,
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Conductivity of drugs used for iontophoresis. | The electrical conductivities of drugs were measured in vitro using a conductivity MHO-meter. These experiments indicate that local anesthetics, vasoconstrictors, some corticosteroids, several anticancer drugs, and several antiviral agents are suitable for iontophoresis. The contribution to conductivity of buffers and ... | 702,299 | [
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Mass fragmentographic determination of methadyl acetate in urine using stable isotope labeled analog as internal standard. | A quantitative GLC-mass spectrometric assay was developed for the determination of methadyl acetate in urine. The assay utilized selective ion focusing to monitor, in a GLC effluent, the M--15 ion generated by electron-impact ionization of methadyl acetate. Methadyl acetate-d4 was used as an internal standard. The assa... | 702,312 | [
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Color analysis of dextrose solutions using a color difference meter. | A method for quantitating color measurements in dextrose solutions by using a color difference meter is described. This method was shown to correlate well with standard American Public Health Association (APHA) color measurements. A mathematical relationship was developed relating yellowness index values to APHA number... | 702,313 | [
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0.07293556... |
Carrier-mediated transport of the organic cation procaine amide ethobromide by isolated rat liver parenchymal cells. | Using hepatocytes isolated by collagenase perfusion, we studied the kinetic characteristics of the uptake process for procaine amide ethobromide (PAEB). Determination of initial uptake velocities (Vo) at substrate concentrations from 30 to 400 micrometer demonstrated a saturable process with a Km of 54 +/- 10 micromete... | 702,324 | [
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Central cholinergic and noradrenergic stimulation in spontaneously hypertensive rats. | In order to test the integrity of central receptors, spontaneously hypertensive rats (SHR) of the Okamoto strain and weight-matched control rats of the Wistar Kyoto (WKY) strain were given intracerebroventricular (i.vt.) injections of carbachol and norepinephrine. The rats, in an unanesthetized, unrestrained state, wer... | 702,327 | [
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Handling of triamterene by the isolated perfused rat kidney. | Quantitative studies on the renal handling of [3H]triamterene were performed in an isolated perfused rat kidney with near normal function and in an isolated kidney with negligible filtration rate, but preserved perfusate flow rate. The excretory pattern for [3H]triamterene is compatible with that of other weak bases su... | 702,330 | [
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Kinetics of metabolite formation and elimination in the perfused rat liver preparation: differences between the elimination of preformed acetaminophen and acetaminophen formed from phenacetin. | Both [14C]phenacetin and [3H]acetaminophen in tracer concentrations were perfused simultaneously once through the rat liver preparation at a constant perfusate flow rate (10 ml/min), and the rates of appearance of [14C]acetaminophen and [3H]acetaminophen in the effluent were compared. The data indicated that the extrac... | 702,339 | [
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Pharmacological analysis of the action of diuretics in the newborn pig. | The effects of furosemide, ethacrynic acid, hydrochlorothiazide and amiloride on renal function of newborn piglets, 5 to 10 days old, were evaluated. Furosemide and ethacrynic acid were the most effective diuretics. Furosemide infusion at 0.5 mg/kg/hr inhibited reabsorption of 21% filtered sodium and ethacrynic acid, 1... | 702,345 | [
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0.023124... |
Vascular and metabolic responses to adrenergic stimulation in isolated canine subcutaneous adipose tissue at normal and reduced temperature. | 1. The circulatory and metabolic effects of temperature reduction were studied in autoperfused canine subcutaneous adipose tissue in situ. 2. Cooling the adipose tissue sufficiently to reduce venous effluent temperature by 5--6 degrees C decreased blood flow from an average of 6.4--4.1 ml. min-1 . 100g-1. 3. Vasoconstr... | 702,388 | [
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0.3259228,
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The role of the cat choroid plexus in regulating cerebrospinal fluid magnesium. | 1. The regulation of c.s.f. Mg concentration was studied using the cat choroid plexus isolated in a chamber in situ. 2. An increase in plasma Mg concentration was accompanied by the usual reciprocal decrease in plasma Ca concentration. Chamber fluid Ca concentration was unaffected. 3. Hypermagnesemia (plasma Mg concent... | 702,402 | [
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The Department of General Practice at the Erasmus University of Rotterdam. | The philosophy which provides the framework for looking after patients, teaching, and research at the University Department of General Practice in Rotterdam is described and the need stressed that this philosophy should be discussed continually with other departments and with local general practitioners.In particular I... | 702,448 | [
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The benefits to an elderly population of continuing geriatric assessment. | There is currently great interest in the care of the elderly in general practice and discussion about the role of surveillance programmes. We report a comparison between two surveys of an elderly population carried out with a view to determining the difference in findings between two surveys of the same population.Each... | 702,458 | [
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Symptom prevalence in the community. | The prevalence of physical symptoms among a sample of patients registered at a health centre is described as recorded from home interviews. The number of physical symptoms per person is then correlated with personal characteristics and environmental factors, using computer programmes. | 702,465 | [
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The anastomotic leak syndrome. | To evaluate the mechanisms, diagnosis, treatment, and prevention of the anastomotic complex, 151 anastomotic disruptions (representing a 20-year-study) were analyzed from records of St. Frances General Hospital, Pittsburgh. These leaks are serious postoperative problems which require individualized treatment. Preventio... | 702,545 | [
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Racism, narcissism, and integrity. | Recently there has been much literature pertaining to the psychodynamics of narcissism and its relation to psychopathological and normal psychic functions. While these models of the mind are primarily aimed at understanding individual behavior in the therapeutic relationship, they are also useful in clarifying one's th... | 702,554 | [
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Postmortem examination of an x-ray tube. | During rapid sequence radiographics in a special procedure room, unexplained random loss of contrast was observed. The effective focal-spot size, output, and the half-value layer of the tube was measured. The focal-spot size was within the +50 percent established by the National Electrical Manufacturer's Association (N... | 702,556 | [
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0.4378628,
0.08931763,
0.2433948,
... |
Splenic abscess in a tropical zone. | Abscess of the spleen is uncommon. The reported incidence varies widely and early observations of an association with tropical fevers are no longer evident. The pathogenesis is ill-understood and diagnosis is difficult and usually late. A careful clinical examination combined with the recent utilization of (99)Techniti... | 702,559 | [
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0.08368965,
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0.2384821,
-0.08021505,... |
Physical examinations in inner-city preschools. | This paper describes the physical examination program started in March 1974 and carried out by the Anacostia Headstart Program in Washington DC. Annual totals of 362, 274, and 458 preschool children were examined in 16 schools during the 1973-1974, 1974-1975, and 1975-1976 school years, respectively. For these years, 8... | 702,588 | [
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Evaluation and treatment of patients with impotence. | Impotence is a common problem of adult males. Thorough history from both partners, physical examination, and laboratory work uncover a small minority who are suffering from an organic cause. The majority of such patients have a psychological basis for the condition. In the absence of demonstrated organic disease, psych... | 702,601 | [
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... |
Absence of phospholipase activity in bacteriophage T4. | We assayed phospholipase activity in T4Dt+ and in t mutant phage grown under permissive and restrictive conditions. There was no correlation between the presence of the t+ gene product and phospholipase activity. Phospholipase activity in phage lysates could be attributed to the presence of bacterial debris or to the u... | 702,644 | [
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0.0620291,
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Cell-mediated immune competence in patients with prostatic carcinoma. | The immune competence of 65 patients with prostatic cancer was evaluated by 2 in vivo and 2 in vitro tests to study the contribution of host factors to the progress of the disease. Patients with benign prostatic hypertrophy served as controls. Our results indicate that the delayed skin hypersensitivity response to comm... | 702,665 | [
0.1280134,
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Iglesias articulated endoscopy teaching attachment. | A new articulated teaching attachment with a single joint is described. The attachment allows a 360-degree rotation in 3 planes (sagittal, horizontal and frontal) by the 3 rotary unions at the single joint with only 2 tubes. Simultaneous observation by 2 persons and the operator is achieved by combining 2 of these opti... | 702,670 | [
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0.06189737,
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... |
Short stay surgery in pediatric urology. | Short stay surgery represents an innovation in the delivery and cost of medical care. The short stay surgical unit at the Children's Hospital of Michigan has provided urologic care for 311 children during the most recent 12 months of its operation. Eighteen patients (5.7 per cent) required postoperative hospitalization... | 702,672 | [
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0.08704376,
0.08597144,
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0.01408727,
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0.0038032... |
Scintigraphic assessment of left ventricular aneurysms. | Thirty-five patients with coronary artery disease and possible left ventricular aneurysm underwent routine clinical examination, gated cardiac blood pool scintigraphy, and radionuclide cineangiography. Thirty-three of the 35 patients had coronary angiography and contrast left ventriculography. Sixteen patients had segm... | 702,727 | [
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0.06417958,
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... |
Botulism and guanidine. Ten years later. | Guanidine hydrochloride was introduced as an adjunct in the treatment of botulism in 1968. It has been reported to be of benefit in 39 cases and of no benefit in 13 cases. No serious side effects have occurred with the short-term therapy required in botulism. Our two cases are similar to earlier cases in that the impro... | 702,753 | [
-0.3968705,
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0.05844724,
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0.08540744,
-0.04244547,
-0.182807,
0.3903777,
0.3048663,
0.279179... |
Brainstem acetylcholine sensitive neurons activated by cutaneous impulses in cats. | In order to determine the cholinoceptive mechanism associated with cutaneous inhibition of jaw-closing and lumbar motoneurons, the area related to the inhibition produced by stimulation of the superficial radial nerve was identified by a lesion within the pontomedullary reticular formation and effects of drugs upon neu... | 702,939 | [
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-0.4084365,
0.1170117,
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0.02367908,
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0.1125841,
0.2261867,
0.3096943... |
Enhancement of 5-hydroxytryptamine-induced contraction of the guinea pig ileum by a new sulfur compound, tripropylsulfonium bromide. | In the presence of tripropylsulfonium bromide (TPS) (1 X 10(-4) g/ml), a new compound, the phasic contraction of the isolated guinea pig ileum to 5-hydroxytryptamine (5-HT) (5 X 10(-7) g/ml) was consistently enhanced ("TPS effect"). TPS alone increased moderatley the spontaneous movement of the ileum. When the contract... | 702,940 | [
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0.09658726,
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0.1673998,
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0.4006287,
0.3868914,
0.05239658,
0.1167786,
-0.07497197,
... |
[Psychophysiological correlations in paroxysmal forms of cardiac rhythm disorders]. | Fifty-two patients with paroxysmal disorders of cardiac rhythm were under observation for periods of 6 months to 3 years. Paroxysmal supraventricular tachycardia was registered in 16, ventricular tachycardia in one, paroxysmal cardiac fibrillation in 35. The method of comprehensive examination of personality (modified ... | 703,045 | [
-0.1341513,
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0.1153214,
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0.4300475,
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0.5234579,
-0.09719981,
-0.01875522,
-0.199142... |
[Surgical treatment of mitral stenosis]. | Open and closed methods of mitral commissurotomy are appraised in comparison. Open correction of mitral stenosis was performed under conditions of extracorporeal circulation, closed correction was accomplished by the instrumental method from right and left approaches. The advantages of open mitral commissurotomy in com... | 703,052 | [
-0.1095756,
0.4295471,
-0.1304792,
-0.01032738,
-0.1248533,
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0.2835943,
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0.1082113,
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0.3956478,
-0.02038779,
-0.154... |
[Indices of the sympathetic-adrenal and hypophyseal-adrenocortical system reactions in myocardial infarct patients during physical rehabilitation]. | Changes in the content of hormones of the cortical and medullary layers of the adrenals in 40 patients with myocardial infarction were studied during physical rehabilitation. Increased activity of the sympathetico-adrenal and hypophyseal-adrenocortical systems after therapeutical gymnastics was revealed. The greatest s... | 703,063 | [
-0.207789,
0.1486507,
0.05970593,
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0.4567351,
0.3555581,
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0.02791376,
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Breeding and reproductive physiology of the desert gerbil, Meriones crassus. | Meriones crassus were bred under laboratory conditions. The mean gestation period was 21.6 days, with a range between 21 and 24 days. The mean litter size was 4.4. Mean litter size varied from 3.4 in October to 5.6 in April. Studies of vaginal smears revealed four phases of the estrous cycle, and the mean length of thi... | 703,248 | [
0.1365264,
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0.2909189,
0.3601203,
0.08483654,
-0... |
Acoustic-reflex dynamics for pulsed signals. | Contralateral acoustic-reflex measurements were taken for 10 normal-hearing subjects using a pulsed broadband noise as the reflex-activating signal. Acoustic impedance was measured at selected times during the on (response maximum) and off (response minimum) portions of the pulsed activator over a 2-min interval as a f... | 703,278 | [
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0.2448548,
-0.02786418,
0.1801989,
... |
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