title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Kinetics and equilibrium studies on autologous and heterologous recombinations of heavy and light chains of myeloma proteins. | 1. The kinetics of the heterologous recombination reaction of alkylated H chains of a myeloma protein (Jo) with alkylated L chains of another myeloma protein (Ita) were studied by following changes with time in the circular dichroism at 235 nm and the results were compared with those for the autologous recombination of... | 6,439 | [
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Trinitrophenylation of nucleic acids and their constituents. | 1. Under relatively mild conditions, nucleic acids and their constituents were trinitrophenylated with 2,4,6-trinitrobenzenesulfonate (TNBS) in aqueous solution (pH 8-11), yielding reddish-orange trinitrophenyl (TNP) derivatives. Guanine residues were trinitrophenylated on the base residues at the 2-amino group (N2-TNP... | 6,442 | [
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Cytochrome P-450 of bovine adrenal mitochondria. Ligand binding to two forms resolved by EPR spectroscopy. | The binding of cholest-5-ene-3beta,20alpha-diol (20alpha-hydroxycholesterol), 11-deoxycorticosterone, and aminoglutethimide to cytochrome P-450 in bovine adrenal mitochondria was measured by changes in optical spectra at room temperature and by EPR spectra at 14 K. The two methods provided nearly identical quantitation... | 6,460 | [
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Re-evaluation of the kinetics of lactate dehydrogenase-catalyzed chain oxidation of nicotinamide adenine dinucleotide by superoxide radicals in the presence of ethylenediaminetetraacetate. | The chain oxidation of lactate dehydrogenase-bound NADH initiated by superoxide radicals and propagated by oxygen was studied with pulse radiolysis. The kinetic parameters were re-evaluated in a system with carefully purified reagents (water and other chemicals) and in the presence of EDTA. The rate constant for the ox... | 6,464 | [
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Description of a polyvalent conjugate and a new serogroup of Bacteroides melaninogenicus by fluorescent antibody staining. | A polyvalent conjugate (fluorescein isothiocyanate-labeled antibody reagent) containing serogroups A, B, and C conjugates was prepared. This polyvalent conjugate gave a positive fluorescent antibody (FA) stain with 49 stains of Bacteroides melaninogenicus representing serogroups A, B, and C. When additional strains (92... | 6,487 | [
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beta-Adrenergic receptors in rat brain. | 125I-Iodohydroxybenzylpindolol ([125I] IHYP), a potent beta-adrenergic receptor antagonist, has been used to study beta-adrenergic receptors in rat brain. Binding of [125I] IHYP (30 pM) to a membrane fraction min and dissociation took place with a half time of about 16 min. Phentolamine (10(-4) M) decreased non-recepto... | 6,494 | [
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[Study of fetal heart rate in deliveries complicated by fetal acidosis]. | A study has been carried out on the parameters of the graph of the fetal heart rate (the basal rate and dips) in 44 cases of acute fetal distress with a pH lower than 7.2 in the blood and in 30 normal deliveries. The statistical analysis confirms that there is a significant rise in the number of heart rate abnormalitie... | 6,505 | [
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The cleaning and disinfection by heat of bedpans in automatic and semi-automatic machines. | This work is concerned with the cleaning and disinfection by heat of stainless-steel and polypropylene bedpans, which had been soiled with either a biological contaminant, human serum albumin (HSA) labelled with technetium-99m 99m(Tc), or a bacteriological contaminant, streptococcus faecalis mixed with Tc-labelled HSA.... | 6,591 | [
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On the interaction of NH+4 and Na+ fluxes in the isolated trout gill. | 1. Sodium influx was measured in isolated, previously perfused gill arches of rainbow trout, Salmo gairdneri, by measuring incorporation of 22Na into gill tissue following timed exposure to a 1 mM 22NaCl medium. Transport rates approximated those estimated for intact fish and were linear for at least one min. 2. NH4Cl-... | 6,610 | [
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The persistence of dextran 70 in blood plasma following its infusion, during surgery, for prophylaxis against thromboembolism. | An infusion of dextran (mean molecular weight 70000) in normal saline (either 1 litre or 500 ml) was given to patients undergoing hysterectomy. The infusion was started at induction of anaesthesia and continued throughout the operation and for up to 5 h thereafter. The rate of elimination of dextran was independent of ... | 6,646 | [
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The absorption and elimination of metoclopramide in three animal species. | The absorption and elimination of metoclopramide have been studied in the rat, rabbit and dog. Thin-layer chromatography followed by photodensitometry was used for the analysis of the unchanged drug and its metabolites. N-De-ethylation is an important Phase I metabolic reaction and conjugation with glucoronic acid and ... | 6,647 | [
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The isolated cremaster muscle preparation and (external) spermatic nerve-cremaster muscle preparation of the guinea-pig. | The isolated cremaster muscle preparation and spermatic nerve-cremaster muscle preparation of the guinea-pig were studied in vitro to determine their suitability as pharmacological test models. The preparation was contracted by acetylcholine, carbachol, succinylcholine and decamethonium (pD2 values, 4-2, 5-3, 7-3 and 7... | 6,717 | [
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Aggregation of antiacetylcholine drugs in aqueous solution: micellar properties of some diphenylmethane derivatives. | Light scattering methods have been used to examine the aggregation in aqueous solution of a series of antiacetylcholine drugs based on the diphenylmethane nucleus. The drugs investigated included adiphenine hydrochloride, piperidolate hydrochloride, benztropine mesylate, orphenadrine hydrochloride, chlorphenoxamine hyd... | 6,747 | [
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Anomalies in some properties of powder mixtures. | Mixtures of lactose and paracetamol and of lactose and oxytetracycline exhibit anomalous properties. The mean particle sizes, tensile strengths and flow properties of the mixtures are not proportionally intermediate between those of the constituents. The results are ascribed to changes that occur in the packing arrange... | 6,749 | [
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Preliminary investigations of the metabolism and pharmacological activity of beta-hydroxytryptamines in mammals. | beta-Hydroxytryptamine and beta-hydroxy-5-hydroxytryptamine were incubated with rat liver slices and oxidative deamination was established as the main route of metabolism: in both instances the corresponding indole-3-glycollic acids and indole-3-ethane diols were the major metabolites. However, the rates of deamination... | 6,751 | [
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The influence of growth medium on the interactions between Bordetella pertussis and Staphylococcus aureus. | Previous observers showed that many strains of Staphylococcus aureus stimulated the growth of Bordetella pertussis but we have found the reverse: the growth of all available strains of B. pertussis on charcoal-agar medium was inhibited by a standard strain of S. aureus; and 17 of 18 strains of S. aureus (as well as sev... | 6,798 | [
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Monitoring of midmyocardial and subendocardial pH in normal and ischemic ventricles. | Midmyocardial and subendocardial pH monitoring was used as an indirect method for continuous evaluation of regional canine myocardial ischemia. Left ventricular midmyocardial pH (pHm) at 4 mm. depth was monitored in 10 dogs, under resting conditions, by means of a 5 mm. Beckman pH probe. pHm was 6.96 +/- 0.03, recorded... | 6,826 | [
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[The use of "mesh graft" in traumatology]. | Vandeput and J. Tanner's method for the reconstruction of the reticular grafting skin has been used and is recommended by the authors for the treatment of not only the thermic--, but of the mechanis lesions. The author has obtained very good results. The method is discussed and its advantages are pointed out. | 6,827 | [
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[Solitary tuberculoma in the tendonous section of the m. quadriceps]. | A case of isolated tuberculosis observed in the tensinous part of the quadriceps muscle is reported by the authors. The rarity of the case is pointed out. A few possibilities of the development of this tuberculoma are dealt with. In the authors' case the focus developed probably after haematogenous generalization. One ... | 6,828 | [
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[Incidence of blood aspiration in fatal fractures of the base of the skull]. | The frequency of blood inhalation has been examined by the authors in the 15 years' material of the Institute of Forensic Medicine of the "Semmelweis" University Medical School. Out of 51.308 post mortem examinations 487 cases of isolated basicranial fractures were found. Out of them in 265 cases (=54%) blood inhalatio... | 6,831 | [
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[Takayasu-Onishi arteritis. Current etiopathogenetic aspects]. | By Takayasu-Onishi's arteritis is meant an arteritic process with unknown aetiology which electively affects young women, seemingly of prevalently Asiatic stock. The disease concerns almost exclusively large elastic arteries and presents clinically with early preocclusive symptomatology followed, after a varying period... | 6,924 | [
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Dibenzepin and amitriptyline in depressive states: comparative double-blind trial. | Dibenzepin and amitriptyline appeared to be equally efficacious in controlling target symptoms of depressive reactions. These results appear to be consistent with pharmacological profiles of the two drugs which are both tricylic compounds. Control of target symptoms occurred in an undulating and non-progressive manner ... | 6,928 | [
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[The effect of ACTH and several antimetabolites of vitamin B6 on the activity of tyrosine aminotransferase in the liver of intact and hypophysectomized rats]. | ACTH injected intraperitoneally in a dose of 140 Units per 1 kg of body weight to intact rats or to rats subjected to hypophysectomy 24 hours before the experiment produced an increase in the activity of tyrosine-aminotrasferase in the liver (4.5 or 2.5 times, respectively) in comparison with the normal. D-cycloserine ... | 6,954 | [
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Acute renal effects of new beta-adrenergic receptor site blocking agents on renal function. | The effects of two new beta blockers on renal function have been studied. There were significant decreases in urine flow, urea clearance, sodium and chloride excretion rates after acute administration. Fractional excretion of sodium (FeNa) fell significantly but did not continue to fall during chronic administration. B... | 6,959 | [
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Nucleation of microbiologic calcification by proteolipid. | The component of crude phospholipid responsible for B. matruchotii calcification was isolated. Crude phospholipid, extracted from the microorganism, was separated into five fractions by column chromatography. A single, protein-containing fraction catalyzed apatite formation in a metastable calcium phosphate solution. T... | 6,970 | [
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Prevention of memory loss following puromycin treatment. | Female C57BL/6J mice were trained on a one trial passive avoidance response. Twenty-four hours later, they were treated with puromycin in combination with either 2.0 or 10.0 mg/kg of amphetamine, 0.3 mg/kg of strychnine, or 20.0 or 50.0 mg/kg of pentylenetetrazol. Tests one week after training revealed that treatment w... | 6,975 | [
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Exposure in vivo of agoraphobics: contributions of diazepam, group exposure, and anxiety evocation. | Fifty-seven chronic agoraphobic outpatients were treated by 12 hours of exposure in vivo on four days over two weeks to check the effects of oral diazepam versus placebo during group exposure, group versus individual exposure, and high versus medium anxiety arousal during individual exposure. The controlled parallel de... | 6,985 | [
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Avoidance of graft versus host reactions in cured W-anemic mice. | Graft-versus-host reactions of parental cells in F1 hybrids were studied with two unrelated inbred strains of mice that differed at the mouse histocompatibility locus. W-anemic F1 recipients were compared with lethally irradiated normal F1 recipients. Both sets of recipients were populated by marrow and spleen cell gra... | 7,035 | [
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[Transparency of analytical results found by different methods of electrophoresis studies on casein (author's transl)]. | The electrophoretic mobility of the major casein components has been studied on different carriers. Besides free electrophoresis and paper electrophoresis starch gel, polyacrylamide gel and cellulose acetate gel have compared. With urea buffer mixtures of neutral to alkaline pH a mobility scale on all gels was found co... | 7,057 | [
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[Examinations to phenomenon of shock-lung (author's transl)]. | The pathogenesis of shock lung as well as the success of therapy in this condition was studied in 79 cases of extrathoracic trauma. The water-, hemoglobin-, and DNA contents of the lungs were measured in order to determine the extent of edema, the rate of perfusion, and proliferation. The cases were divided into two gr... | 7,060 | [
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The synthesis and properties of N6-substituted 2-amino-purine derivatives. | 1. The synthesis, ultraviolet absorption spectra, and behaviour in alkali of N6-methoxy-, N6-methyl, hydroxy-, and N6-hydroxy-2-aminopurines have been described 2. N6-Methoxy-2-aminopurine riboside 5'-pyrophosphate has been prepared and used for polymerization with polynucleotide phosphorylase. 3. The copolymer contain... | 7,092 | [
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[Vegetation analysis used for the detection of exophile tick populations in the south-east of France: the example Ixodes ricinus (Linne 1758) (acarina, ixodoidea)]. | The cross-linking relation between the evidence of outside living tick populations and specific vegetation units allows for efficiently using the vegetation maps, and more especially the medium scale maps. Ixodes ricinus is referred to here as an example. The limitations of this data derived from such maps are evaluate... | 7,119 | [
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[An abnormally formed Ctenophthalmus assimilis assimilis (siphonapteres hystrichosyllidae)]. | A female flea is described the body of which is abnormally formed and compressed. It is characterized by a split along its back, raised up abdominal segments and by a shortening of its head. These anomalies might be explained by longitudinal compression of the body during pupation. The possibility of a mutation is not ... | 7,121 | [
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[Epidemic of autochthonous hepatic and intestinal amebiasis in a place near Grenoble]. | We had the opportunity of studying an epidemic of autochthonous amoebiasis occurring in the autumn of 1974 in a small town of 4000 inhabitants 30 km from Grenoble. Attention was originally attracted by the occurrence in this town of two cases of hepatic amoebiasis and one of intestinal amoebiasis identified by rectosco... | 7,124 | [
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Mucocutaneous lymph node syndrome in the United States. | Sixteen patients with an unusual and distinct symptom complex were encountered during a four-year period. Principal features of this syndrome are (1) fever lasting more than seven days; (2) conjunctival injection; (3) changes in the mouth consisting of erythema of the oropharynx, "strawberry tongue", and erythema of th... | 7,134 | [
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A decrease in cell-mediated immunity in uremia associated with an increase in activity of suppressor cells. | The graft-versus-host (GVH) reactivity of uremic and control spleen cells was studied by popliteal lymph node assay in the rat. The reaction evoked by cells from animals with severe uremia was conspicuously weaker than that evoked by control cells. The magnitude of the GVH reaction induced by control cells was directly... | 7,140 | [
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Respiratory effects of 'lissive" anaesthesia using gallamine. | 'Lissive anaesthesia', the administration of a small dose of a non-depolarising muscle relaxant to a patient breathing nitrous oxide, oxygen and an anaesthetic vapour, is a technique popularly employed for minor procedures. In this study, the effects of intravenous gallamine triethiodide (40 mg) on the blood-gas status... | 7,150 | [
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Psychomotor skills during subacute treatment with thioridazine and bromazepam, and their combined effects with alcohol. | Twenty paid healthy students volunteered for a doubleblind cross-over trial on the effects of two weeks' treatment with placebo, thioridazine and bromazepam on psychomotor skills. The doses used were thioridazine 10 mg t.i.d. during the first week and 20 mg t.i.d. during the second week, or 6 mg of bromazepam t.i.d. du... | 7,178 | [
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Cultivation of mycoplasmas in a modified tissue culture medium. | A new medium, which contained a chemically defined tissue culture base ("medium 199"), was developed for the cultivation of mycoplasmas. When supplemented with albumin, glucose, serum, and yeast extract, the new medium adequately supported the growth of Mycoplasma and Acholeplasma species. | 7,199 | [
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[Studies on the properties of acid erythrocyte phosphatase in sheep and the isoenzymes of sheep and goat acid erythrocyte phosphatase]. | Ovine erythrocytic acid phosphatase showed two peaks of activity at pH 5.0 and 5.7 in acetate buffer with p-nitrophenylphosphate as substrate. The enzyme was only slightly inhibited by fluoride and L-phenylalanine, but high concentrations of urea strongly inhibited it. Activity of the enzyme was greater in goat erythro... | 7,216 | [
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[Origination and importance of glycolysis for malignomas and utilization of this property in the chemotherapy of cancer (author's transl)]. | Glycolysis is not of importance for the process of carcinogenesis. It is very likely, however, that certain molecular-biological and genetic changes are produced which enable the malignant cell to develop an intensive glycolysis, for instance, to form specialized glycolytic isoenzymes already during oncogenesis, and ma... | 7,218 | [
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Isolation, by partial pepsin digestion, of the three collagen-like regions present in subcomponent Clq of the first component of human complement. | 1. Digestion of human subcomponent C1q with pepsin at pH4.45 for 20h at 37 degrees C fragmented most of the non-collagen-like amino acid sequences in the molecule to small peptides, whereas the entire regions of collagen-like sequence that comprised 38% by weight of the subcomponent C1q were left intact. 2. The collage... | 7,240 | [
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Polar-group behaviour in mixed monolayers of phospholipids and fusogenic lipids. | 1. The surface potentials of mixed monolayers of synthetic phospholipids with lipids that are fusogenic for hen erythrocytes were investigated. 2. At pH 5.6 and 10, but not at pH2, mixed monolayers of the fusogenic lipid, glycerol mono-oleate, with phosphatidylcholine exhibited negative deviations from the ideality rul... | 7,246 | [
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[MASCA-model of biochemical-pharmacological drug research/Part VIII: Examples (author's transl)]. | In this report two examples (inhibition of alcohol dehydrogenase by pyridine and benzamide derivates) are given for the interpretation of the MASCA-model. | 7,279 | [
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Guanylate cyclase. Existence of different forms and their regulation by nucleotides in calf uterus. | The activity of calf uterus guanylate cyclase (EC 4.6.1.2) exists in at least two and most probably three distinct forms. The cytosolic enzyme exhibits hyperbolic substrate curves with respect to GTP and Mn2+, while the particulate cyclases (nuclear and microsomal)display sigmoidal (GTP) and hyperbolic (Mn2+) relations... | 7,317 | [
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Ca++ binding properties of human prothrombin. | The binding of Ca++ to human prothrombin has been investigated by equilibrium dialysis. The protein exhibited a positive cooperativity phenomenon for the first three Ca++ bound. Eleven to twelve Ca++ binding sites have been found. They could be differentiated in terms of two classes of sites with respect to their Ca++ ... | 7,324 | [
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[A method of continuous recording on microsamples of the Hb-O2 association curve. II. A study of Bohr effect and carbamino-formation (author's transl)]. | The authors have worked out an adaptation to microsamples (200-400 mul) of the DUVELLEROY et al. method, allowing the continous registration of the O2-Hb association curve. The microsample being diluted in buffer solution, it is possible to predetermine its pH and PCO2. The prefixed conditions are maintained during the... | 7,333 | [
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Pain as a major cause of postoperative nausea. | The incidence of nausea in relation to pain was recorded in 104 patients after abdominal operations. Ten per cent of the patients had episodes of nausea not related to pain. One hundred and fourteen episodes of concomitant pain and nausea were recorded in 61 patients (58.6 per cent). The intravenous injection of morphi... | 7,347 | [
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Influence of DNA acidification on DNA premelting and template properties. | Acidification of a T7 DNA sample was found to be partly irreversible as ultraviolet difference spectra measured at various sub-melting temperatures were different from those observed for a 'normal' DNA sample. This implies some subtle conformational change which is not reversed by return to neutral pH. In the same cond... | 7,456 | [
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A new type of fluorocarbon liquid oxygenator. | A new oxygenator based on gas transfer across liquid-liquid interfaces (liquid oxygenator) is introduced. Perfluorinated chemicals are used as gas carriers. This liquid oxygenator differs from others in its concept basing on the dispersion of the blood droplets in an inert liquid by means of shear forces. This method a... | 7,460 | [
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Purification and some properties of NADP+ -specific isocitrate dehydrogenase from an extreme thermophile, Thermus flavus AT-62. | Thermostable NADP+ -specific isocitrate dehydrogenase (EC 1.1.1.42) was purified from crude extract of an extremely thermophilic bacterium Thermus flavus AT-62 through DEAE-cellulose column, acetone fractionation, DEAE-Sephadex A-50 column and isoelectric focussing. The enzyme was purified about 500-folds in its specif... | 7,466 | [
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Studies on the inhibition of thermolysin. | Thei nhibition of the thermolysin catalyzed hydrolysis of FA-Gly-Leu-NH2 and FA-Gly-Phe-NH2 has been reported. The results suggest a model for substrate and inhibitor binding involving the hydrophobic specificity pocket, Arg-203 and Glu-143. | 7,470 | [
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Hemoglobin function in stored blood. XIII. A citrate-adenine preservative with optimal pH to maintain red cell 2,3-DPG (function) and ATP (viability). | Increasing pH by a 0.5 increment over the commonly used preservative, acid-citrate-dextrose with adenine (ACD-Ad), results in a significant improvement in 2,3-DPG, with no significant loss in concentrations of ATP. The intermediate pH preservative, 6.0, also had ATP concentrations which equaled those of the low pH pres... | 7,517 | [
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An analysis of the relationships among obesity, plasma insulin and hepatic lipogenic enzymes in "viable yellow obese" mice (Avy/a). | The development of obesity, hyperinsulinemia and six hepatic lipogenic enzymes in Avy/a mice were compared to that in a/a mice. Correlation between body weight, liver weight, plasma insulin concentration and activities of hepatic enzymes was analyzed. In the Avy/a mice, body weight, liver weight and plasma insulin leve... | 7,520 | [
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Potentiometric studies on benzeneboronic acid-alpha-chymotrypsin interactions. | When the competitive inhibitor benzeneboronic acid (BBA) forms a complex with alpha-chymotrypsin [EC 3.4.21.1] protons are released in the acidic pH region. The proton release can be measured by a difference potentiometric technique. The proton release is also observed in chymotrypsinogen A but not in TRCK-, DIP-, and ... | 7,550 | [
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... |
Comparative studies on polyguanylate polymerase and polyadenylate polymerase activities in the DNA-dependent RNA polymerase I fraction from cauliflower. | The properties of poly(G) polymerase and poly(A) polymerase activities in the DNA-dependent RNA polymerase [nucleosidetriphosphate: RNA nucleotidyltransferase EC 2.7.7.6] I fraction from cauliflower (Brassica oleracea var. botrytis) were comparatively investigated. The pH optimum, the effect of ionic strength, the effe... | 7,554 | [
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0.025... |
Studies on the molecular species of DNA polymerase extracted from rat ascites hepatoma cells. | DNA polymerase [EC 2.7.7.7] activities present in hypotonic extract from rat ascites hepatoma AH130 cells were eluted in three separable peaks on DEAE-cellulose column chromatography. Peak I activity had an alkaline pH optimum, and was relatively resistant to SH-blocking reagents and salt concentration. These propertie... | 7,555 | [
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Duodenal immunoglobulin deficiency in graft versus host disease (GVHD) mice. | The small intestine is a well documented target organ in mouse and human GVHD, and diarrhea is a prominent part of the clinical GVHD syndrome. Although a plethora of systemic immune deficits has been documented in GVHD, the integrity of the small intestinal immune system has not been investigated. A correlation has not... | 7,629 | [
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Comparison of uptake and binding of disodium cromoglycate and phenol red in rat lung. | In rat lung slices 3H-disodium cromoglycate (3H-DSCG) (0.001 mM) was taken up rapidly and 3H-DSCG tissue spaces, which equilibrated by 30 minutes, remained constant over a 4-hour incubation period. In contrast, 35S-phenol red (0.001 mM) accumulated in lung slices to a much greater extent than did DSCG, and the measured... | 7,666 | [
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Permeability parameters of the toad isolated stratum corneum. | A technique for isolating the stratum corneum from the subjacent layers of the epithelium was developed which permits studying the stratum corneum as an isolated membrane mounted between half-chambers. The method basically consists of an osmotic shock induced by immersing a piece of skin in distilled water at 50 degree... | 7,676 | [
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0.164594... |
Hemodynamic effects of beta-adrenergic blockade with pindolol, oxprenolol, propranolol and bufetolol hydrochloride in essential hypertension. | Hemodynamic studies (using (131)I-labeled albumin [RISA]) Were performed before and 5 and 42 weeks after the oral administration of pindolol (av. 30 mg/day), oxprenolol (av. 216 mg/day), propranolol (av. 75 mg/day) or bufetolol hydrochloride (av. 30 mg/day) in 40 patients with essential hypertension. Responders to the ... | 7,688 | [
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[Arterial hypertension and chronic hemodialysis]. | Basing on the literature data and their own observations of patients with chronic hemodialysis the authors have analysed the pathogenesis, course, hemodynamic shifts and possibilities of purposeful treatment in terminal uremia. Besides two variants of the hypertension course (controlled and noncontrolled), a third type... | 7,700 | [
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[Use of beta-blockader visken in children with primary arterial hypertension]. | The effect of Visken was analysed in children with primary arterial hypertension, Stage IB, with reference to their general state, dynamics of cardiac contractions, arterial pressure, cardiac output, and vascular peripheral resistance. The treatment was undertaken in 28 children lasting from 6 to 8 weeks. A multiformit... | 7,701 | [
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[Effect of actinomycin D on transformation of the planulae of Obelia loveni (Allman)]. | The incubation of planulae Obelia loveni in the actinomycin D solution (40 mug/ml) for 3 hrs at 17--20 degrees resulted in the marked inhibition of the process of attachment of planulae to the substrate and their transformation in polyps. A suggestion is put forward that at the final phase of larval development a speci... | 7,762 | [
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0.7549429,
0.04940735,
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Pneumothorax in the respiratory distress syndrome: incidence and effect on vital signs, blood gases, and pH. | We determined the incidence of pneumothorax in 295 infants (mean birthweight, 1,917 gm) with the respiratory distress syndrome (RDS) treated according to the same protocol. Fifty-five infants (mean birthweight, 1,594 gm) developed pneumothorax (incidence, 19%); incidence varied with severity of RDS and intensity of res... | 7,768 | [
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Purification, characterization, and quantitation of the antigen employed in the immunodiffusion test for diagnosis of equine infectious anemia. | Equine infectious anemia (EIA) antigen extracted from the spleen of horses infected with EIA virus was purified by pH treatment, (NH4)2SO4 fractionation and affinity chromatography. The homogeneity of the antigen was indicated by sedimentation rate and sedimentation equilibrium experiments. A S20,w of 0.51 was determin... | 7,782 | [
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Dietary and hormonal regulation of the content of acetyl coenzyme A carboxylase-synthesizing polysomes in rat liver. | Specific polysomes involved the the synthesis of acetyl-CoA carboxylase [acetyl-CoA: carbon-dioxide ligase (ADP-forming), EC 6.4.1.2] have been identified by the binding of 125I-labeled antiacetyl-CoA carboxylase to rat liver polysomes. The binding is highly specific and occurs through the recognition of the nascent pe... | 7,784 | [
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Economizing with psychotropic drugs. | Every health practitioner can reduce the cost of his treatments without compromising their quality. A review of the magnitude of the cost problem with regard to psychotropic drugs, variables which affect cost, the methods by which the clinician can manipulate the variables to reduce costs, and the application of these ... | 7,793 | [
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Drug inhibition of ecto-ATPase and of phagocytosis in leukocytes. | Substituted phenothiazines and tricyclic antidepressants which inhibited the ecto-ATPase in leukocytes also markedly decreased the phagocytic activity of these cells. In affecting either the enzyme or phagocytosis the order of potency of the drugs was similar. Various other CNS drugs were ineffective. The results sugge... | 7,807 | [
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Alpha-N-Benzoylarginine-2-naphthylamide hydrolase (cathepsin BI?) from rat skin. III. Substrate specificity, modifier characteristics, and transformation of the enzyme at acidic pH. | Some properties of rat skin benzoylarginine-2-naphthylamide hydrolase types I (preparations I and AI) and II (preparations II and NII) were studied. Both types were activated by dithiothreitol and EDTA, but responded differently to 1 mM KCN, when benzoylarginine-2-naphthylamide (BANA) was used as a substrate: type I wa... | 7,911 | [
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[Physical and mental fatigue of probable hyperuricemia origin]. | A blood uric acid analysis has been effected on 193 Iranians of the intellectual group aged from 25 to 60, of which the normal average rate for 99 women and 94 men of a normal state are (47.5 +/- 2.73) and (53.62 +/- 2.73) respectively. After having controlled the uricemia of these subjects during a period of three yea... | 7,923 | [
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Electrophoretic separation and characterization of subunits released from influenza virus by detergents. | Subunits released from influenza A/Singapore/1/57 (H2N2) virus by either Triton-X-100 (T-X-100); or sodium lauryl sarcosinate (SLS) or ether were separated by electrophoresis in agarose suspension into a rapidly migrating fraction (I) and a slowly migrating fraction (II). Fraction I obtained after T-X-100 treatment con... | 7,935 | [
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[Resistance test to streptokinase. Its value in the establishing of a thrombolytic treatment using this enzyme]. | The reckoning of the rate of serous anti-streptokinase (ASK) evidenced that 8 p. 100 of the test-sample presented a distinct resistance to Streptokinase (SK), and that this percentage could be more important under certain pathological circumstances. On account of this fact and also because SK injectable preparations ma... | 7,980 | [
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[Nitric oxide production in rice soils (author's transl)]. | Nitric oxide gas evolution from nitrite was studied in vitro in three rice soils by gas chromatography. Autoclaved soils showed an NO evolution when supplemented with nitrite. Yet, when temperature of incubation, soil pH, soil moisture content and nitrite concentration were varied in the three soils, and with addition ... | 7,989 | [
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0.05589711,
0.3416524,
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0.2652446,
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Autolysis of high-GC isolates of Pseudomonas putrefaciens. | High-GC isolates of P. putrefaciens undergo extensive autolysis after growth, resulting in a marked decrease in turbidity and the release of high-molecular-weight DNA which imparts a high viscosity to culture broths. The native DNA released is resistant to attack by the exocellular DNase activity of the culture broths.... | 7,999 | [
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Inhibition of Clostridium perfringens by heated combinations of nitrite, sulfur, and ferrous or ferric ions. | Heating mixtures of sodium nitrite, cysteine, and either ferrous sulfate or ferric chloride at 121 C for 20 min at pH 6.5 or 6.3 produced a potent inhibitor of Clostridium perfringens vegetative cells and spores when added to previously heat-sterilized fluid thioglycolate medium. When the mixtures containing FeSO4 at p... | 8,004 | [
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Hypotensive action of propranolol and a new beta-blocking agent, D-32 in conscious normotensive and renal hypertensive dogs. | The hypotensive actions of dl-propranolol and a new beta-blocking agent, dl-tert-butylamino-3-(2', 3'-dimethylphenoxy)-2-propanol hydrochloride (D-32) were studied in conscious normotensive and renal hypertensive dogs, using a cross-over design. The effects were compared with that of placebo (lactose 200 mg/head, p.o.)... | 8,021 | [
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The effects of proteolytic digestion by trypsin on the structure and catalytic properties of reduced nicotinamide-adenine dinucleotide dehydrogenase from bovine heart mitochondria. | 1. At 21 degrees C incubation of NADH-ubiquinone-1 reductase (Complex 1) with trypsin caused selective inhibition of nicotinamide nucleotide transhydrogenase activity. The reduction of K3Fe(CN)6 by NADH or NADPH was unaffected, but a slow decrease in the rate of reduction of ubiquinone-1 by NADH was observed. 2. The pH... | 8,040 | [
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The regulation of rat liver tryptophan pyrrolase activity by reduced nicotinamide-adenine dinucleotide (phosphate). Experiments with glucose and nicotinamide. | 1. Chronic administration of glucose or nicotinamide in drinking water inhibits the activity of rat liver tryptophan pyrrolase, and subsequent withdrawal causes an enhancement. The enzyme activity is also inhibited by administration in drinking water of sucrose, but not fructose, which is capable of preventing the gluc... | 8,041 | [
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Basic ethers of cyclohexylphenols with beta-blocking activity: synthesis and pharmacological study of exaprolol. | The paper describes the preparation and study of the pharmacological properties of a series of derivatives with the general formula. (see article) where R is a cyclohexyl or cyclohexenyl radical and R1 is a hydrogen, methyl or cyclohexyl. The compounds with a single cycloaliphatic radical ortho to the basic chain, and ... | 8,056 | [
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General pharmacological properties of a new non-opiate antitussive: zipeprol (3024 CERM). I. Action on respiratory function and acute toxicity. | 1-(2-Methoxy-2-phenyl)-ethyl-4-(2-hydroxy-3-methoxy-3-phenyl)-propyl-iperazine-dihydrochloride (zipeprol, Respilene) is a substance of non-phenanthrenic chemical structure. In the cat, it antagonised cough induced by stimulation of the superior laryngeal nerve or by direct mechanical excitation of the sensitive tracheo... | 8,057 | [
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-0.4779419,
0.03854369,
0.1761477,
0.1475438,
0.01473173,
0.00247588,
-0.07852341,
... |
Actions of narcotics on brain dopamine metabolism and their relevance for "psychomotor" effects. | A review is given about the effects of narcotic analgesics, particularly of morphine, on the dopamine metabolism in the corpus striatum and about the relations of these effects to motility and "psychomotor" phenomena. In rats, acute doses of morphine decrease the dopaminergic neurotransmission in brain, without blockin... | 8,059 | [
-0.09941799,
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0.2043069,
0.3004211,
0.09561711,
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0.1497641,
-0.0890923... |
Structural elucidation and properties of 8alpha-(N1-histidyl)riboflavin: the flavin component of thiamine dehydrogenase and beta-cyclopiazonate oxidocyclase. | In addition to 8alpha-(N3-histidyl)riboflavin, 8alpha-(N1-histidyl)riboflavin is also formed during the reaction of Nalpha-blocked histidine with 8alpha-bromotetraacetylriboflavin in a yield of 20-25% of the total histidylflavin fraction. The properties of 8alpha-(N1-histidyl)riboflavin are inditical with those of the ... | 8,076 | [
-0.1802675,
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0.04413933,
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0.02430772,
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0.2987039,
0.01447765,
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0.008861241,
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0.4669181,
0.287576,
0.3496861,
-0.2076194,
... |
Histone interactions in solution and susceptibility to denaturation. | Histone interactions in solution may depend upon treatments used for purification. Optical rotatory dispersion and sedimentation-velocity measurements have been made in a reference solvent, before and after exposure to various treatments, to investigate histone susceptibility to irreversible denaturation. Some acid con... | 8,079 | [
-0.002494842,
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0.122776,
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0.04666278,
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0.3491966,
0.0006620153,
-0.03... |
Mechanism of inhibition of Chromatium D growth by L-methionine. Regulation of L-threonine biosynthesis by the intracellular level of S-adenosylmethionine. | (1) An unusual accumulation of S-adenosyl-L-methionine in Chromatium D was associated with a marked growth inhibition by L-methionine. The inhibition was overcome by L-isoleucine, L-leucine, L-phyenylalanine, L-threonine, L-valine and putrescien. Based on their effects, these compounds are classified into 3 types. (2) ... | 8,102 | [
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0.4609982,
0.1642537,
0.06921913,
... |
Purification and some properties of a neutral protease from human leukocyte granules and its comparison with pancreatic elastase. | 1. A cationic protease has been purified from the granule fraction of blood-donor leukocytes by a preparative method including precipitation by acetone and chromatography on Bio-Gel A 1.5 m, CM-Sephadex C-50 and Sephadex G-G-75. 2. The pH optimum against denatured bovine hemoglobin is 7.4. Gel chromatography indicated ... | 8,109 | [
0.1737742,
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0.3513972,
0.5594673,
0.3669069,
0.3327393,
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0... |
Redox potential of plastoquinone A in spinach chloroplasts. | The redox potential of plastoquinone A in spinach chloroplasts was determined. The midpoint potential of the quinone is about +80 mV at pH 7.0 with an n value of 2. The pH-dependence of the potential is -30 mV per pH between pH 4.0 and 5.7, and -60 mV per pH between pH 5.7 and 8.0. The change of the slope at pH 5.7 is ... | 8,122 | [
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0.1077976,
0.4174152,
0.3261319,
0.2456906,
... |
Effect of portacaval anastomosis on the activities of hepatic enzymes related to cholesterol and bile acid metabolism in rats. | 1. The effect of a portacaval anastomosis on the activities of hepatic enzymes related to cholesterol metabolism was investigated in rats. 2. Portacaval anastomosis led to a fall in body weight and liver weight/body weight ratio, and to a rise in the activities of hydroxymethylglutaryl-CoA reductase and cholesterol 7al... | 8,128 | [
0.04338598,
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0.02767093,
0.235306,
0.1257698,
0.4424504,
0.2157506,
0... |
HCO-3-activated adenosine triphosphatase in intestinal mucosa of the eel. | An HCO-3-activated and SCN--inhibited ATPase (ATP phosphohydrolase, EC 3.6.1.3) found in homogenates of intestinal mucosa of the eel was solubilized by Triton X-100. Optimal HCO-3-concentration and pH for the enzyme were 25 mM and 8.7, respectively. HCO-3-ATPase activity in both homogenate and solubilized preparations ... | 8,150 | [
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0.2550652,
0.1802241,
0.05137137,
-0.4106... |
Electrostatic interactions at charged lipid membranes. I. Effects of pH and univalent cations on membrane structure. | Electrostatic interactions at charged lipid membranes make a significant contribution to the free energy of the system, and can be varied within a wide range by alteration either of the membrane's surface charge density or of the concentration of electrolytes in the surrounding medium. Changes in the charged membrane's... | 8,167 | [
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0.3143167,
0.1723099,
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... |
Successful bone marrow transplantation against mixed lymphocyte culture barrier. | If bone marrow transplantation is to become widely applicable in the treatment of patients with leukemia and aplastic anemia, the necessity to have a perfectly histocompatible donor must be overcome. In an effort to define the roles of HL-A type and mixed lymphocyte culture (MLC) reactivity in the determination of succ... | 8,180 | [
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0.2150659,
0.6052099,
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-0.2223763,
... |
Comparison of propranolol, metoprolol, and acebutolol on insulin-induced hypoglycaemia. | Metoprolol and acebutolol, two supposedly cardio-selective beta-adrenergic recptor blocking agents, were tested in healthy volunteers against propranolol, a non-selective drug, for their effect on blood glucose levels during insulin-induced hypoglycaemia. There was not significant difference between propranolol and met... | 8,187 | [
-0.2571416,
0.01215494,
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0.2319996,
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0.03679798,
0.183459... |
Malignant germ cell tumor in situ in a cryptorchid testis. | A case of a malignant undifferentiated germ cell tumor in situ of an undescended testis diagnosed by needle biopsy is described. Four similar cases have been so far recorded in the literature, all of them in the infertile men with normally descended descended testes. Two of them developed embryonal carcinoma of testis ... | 8,206 | [
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0.06249113,
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0.7612031,
-0.03506954,
-0.1669971... |
Fine structure of complex ocelli of a cubomedusan, Tamoya bursaria Haeckel. | The retina of the distal and proximal lens-bearing complex ocelli are composed of pigmented sensory cells and long pigmented cells. A ciliary sheath from each sensory cell, together with the processes of long pigmented cells, extends through the vitreous layer as far as the capsule that envelops the lens. Each ciliary ... | 8,210 | [
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0.1099308,
0.08901961,
0.3471199,
0.3100652,
0.1369616,
0.381795... |
Intracellular acid-base heterogeneity in nucleated avian erythrocytes. | 1. Intracellular hydrogen ion activity, [H+]i, was extimated in human erythrocytes and in nucleated avian erythrocytes from measurements of the distribution of ammonia and 5,5'-dimethyloxazolidine-2,4'-dione (DMO) between intracellular and extracellular fluid. 2. In human erythrocytes there was no difference between va... | 8,234 | [
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0.03874933,
0.05016489,
0.3801638,
0.1877114,
0.1002909,
-... |
Telephone management of poisonings using syrup of ipecac. | Seven hundred and seventy-six cases were studied during a six-month period to see if induction of emesis could be successfully managed at home by telephone. Emesis was successful in 98.8% of cases. In 6.7% of all cases, symptoms were found at 4-hour follow-up that were referrable to the ingestion, but all were consider... | 8,236 | [
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0.07627796,
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0.3231185,
-0.04225082,
... |
Metabolism of 2,4,5,2',5'-pentachlorobiphenyl in the rat. Qualitative and quantitative aspects. | The metabolism of 2,4,5,2',5'-pentachloro [14C] biphenyl (5-CB) was studied in the male rat. Following iv administration of 5-CB (0.6 mg/kg), 84% of the total dose was excreted within 7 days and 89% of the radioactivity excreted was in the form of 5-CB metabolites. Mass spectral and proton nuclear magnetic resonance an... | 8,291 | [
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0.208614,
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0.04926892,
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0.1376668,
0.3204406,
0.1359352,
0.... |
Inactivation of porcine calcitonin by rat kidney microsome. | Biological activity of porcine calcitonin was most actively inactivated by the rat kidney homogenate than by other tissue homogenates. Among the various subcellular fractions of the rat kidney homogenate examined, microsome fraction was most active in the in vitro inactivation of porcine calcitonin. Inactivation of por... | 8,306 | [
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0.1189905,
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0... |
[Studies of various factors in thyrotropoin releasing hromone TRH) radioimmunoassay for serum (author's transl)]. | To study the significance of TRH in the hypothalamo-pituitary-thyroid axis measurement of TRH in body fluid are needed. We previously reported TRH radioimmunoassay for urine. TRH radioimmunoassay for serum has not established yet, because TRH immunoreactivity is inactivated with serum. We investigated effects of variou... | 8,343 | [
0.1286786,
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0.04367234,
0.3682473,
0.1906575,
0.2627116,
-0.175995,
-0.065... |
[Cutaneous side effects of systemic drugs. Part 4 of a synopsis. 6/7. Drugs affecting the central nervous system. C. Drug-induced photosensitivity. D. Drug-induced changes of skin color]. | This, the fourth part of a synopisis of cutaneous side effects of drugs, covers the drugs affecting the central nervous system: antiepileptics, hypnotics, narcotics and psychopharmaceutics; the myorelaxants and antiallergics follow, and lastly there is a section on drug addiction and placebo. The various cutaneous side... | 8,344 | [
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0.008664668,
0.2828182,
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0.4275934,
0.2448922,
0.2224099,
0.3353691,
0.4212086,
-0.1789241,
... |
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