title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Immunological factors and post coital test in unexplained infertility. | Twenty-four couples facing longstanding primary or secondary infertility underwent semen analysis, PCT, functional evaluation of menstrual cycle, hysterosalpingography and laparscopy. All clinical findings were normal with the exception of PCT which was positive in 13 and negative in 11. All the women underwent a multi... | 8,390 | [
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Purification of properties of dihydroorotase, a zinc-containing metalloenzyme in Clostridium oroticum. | Dihydroorotase +4,5-L-dihydro-orotate amidohydrolase [EC 3.5.2.3]), which catalyzes the reversible cyclization of N-carbamyl-L-aspartate to L-dihydroorotate, has been purified from orotate-grown Clostridium oroticum. The enzyme is homogeneous when subjected to polyacrylamide gel electrophoresis and is stable at pH 7.6 ... | 8,424 | [
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Factors affecting growth and nitrogen fixation of Spirillum lipoferum. | Spirillum lipoferum grows vigorously on malate, succinate, lactate, or pyruvate, moderately on galactose or acetate, and poorly on glucose or citrate. It reduces 15N2. Acetylene reduction rates decrease rapidly when the pH of the culture rises above 7.8. The organism is highly aerobic and had doubling times as low as 2... | 8,430 | [
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Reactivity of the phosphopyridoxal groups of cystathionase. | Aminooxyacetate and alpha-amino-gamma-aminooxybutyrate (canaline) react specifically with the P-pyridoxal groups of cystathionase to produce characteristic changes in the absorption and fluorescence properties of the bound cofactor. The increase in fluorescence at 450 nm was used to monitor the reaction. Aminooxyacetat... | 8,458 | [
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Separation of slow reacting substance of anaphylaxis (SRS-A) from human lung into four biologically active fractions. | Slow reacting substance of anaphylaxis (SRS-A) was released from human lung passively sensitized with ragweed antibody and challenged with specific antigen E. After purification by ethanol extraction, incubation with alkali (0.1 M NaOH for 30 min at 37 degrees C) and chromatography on silicic acid and DEAE-cellulose, h... | 8,568 | [
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Purification, specificity, and hypervariable region sequence of anti-pneumococcal polysaccharide antibodies elicited in a single rabbit. | Four homogeneous antibodies to type VIII pneumococcal polysaccharide (S8) were isolated from the serum of a single rabbit (3322) by affinity chromatography on an S8 immunoadsoebent by utilizing gradient elution with cellobiose and NaCl. The binding properties of these antibodies were determined by a radioimmunoassay wi... | 8,570 | [
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Physiological and pharmacological aids in the differential diagnosis of tremor. | Physiological and pharmacological studies of more than 150 patients with movement disorders are reported. Particular attention is paid to the differentiation of various types of tremor on the basis of rate, rhythm, and pattern of EMG activity in antagonistic muscles. The typical 'tremor-at-rest' of Parkinson's disease-... | 8,592 | [
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The reliability of pH-values in fetal blood samples - A study of the second stage. | In 119 cases fetal blood analysis (FBA) was done in the last 15 minutes before birth together with blood sampling from the umbilical artery (UA) immediately after delivery before the first breath. Using the measured pH-values we investigated the relationship between these variables, in particular the degree of influenc... | 8,601 | [
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The haemolytic effect of phallolysin. | Phallolysin from the toadstool, Amanita phalloides, is a basic protein that causes direct haemolysis of red cells. The dose-response curve is steep; the pH optimum is in the weakly acid range. The rate of haemolysis increases with the concentration of the lysin, the optimal temperature is 20 degrees C. The percentage h... | 8,736 | [
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Desensitization of kitten atria to chronotropic, inotropic and adenylyl cyclase stimulating effects of (-)isoprenaline. | Desensitization of kitten atria with 30muM (-)isoprenaline resulted in a 6-fold and 15-fold increase in the EC50's of (-)isoprenaline for its positive chronotropic effects (sinus pacemakers) and positive inotropic effects (left atria), respectively, but only in a 2-fold increase of the EC50 of (-)isoprenaline for adeny... | 8,737 | [
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The antihypertensive action of several beta-adrenoreceptor-blocking drugs. | The antihypertensive and pulse-slowing effects of racemic propranolol, oxprenolol, pindolol, practolol and d-propranolol were assessed in 54 hypertensive patients. Drug dosage was selected to be proportionate to beta-adrenoreceptor-blocking potency; d-propranolol dosage equalled approximately that of racemic propranolo... | 8,748 | [
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A double blind study of the antidepressants dibenzepin (Noveril) and amitriptyline. | The study undertook to compare the efficacy of dibenzepin and amitriptyline in the treatment of endogenous depression. The outcome of the study was that both drugs appear to be equally effective in the treatment of depression, but dibenzepin was more efficient in reducing associated anxiety. Both drugs are appropriate ... | 8,749 | [
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Spectrophotometric characteristics of bilirubin. | Spectrophotometric characteristics of bilirubin at low concentrations (0.005-2.500 mg/100 ml) have been studied under various physical conditions in order to gain a better understanding of the state of bilirubin when preparing "solutions" for laboratory use. Standing, minimal shaking, or stirring of the bilirubin prepa... | 8,755 | [
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Binding of [3H]dihydroazapetine to alpha-adrenoreceptor-related proteins from rat vas deferens. | The potent alpha-adrenoreceptor blocking agent, azapetine, has been catalytically reduced with tritium gas to form [3H]dihydroazapetine. [3H]Dihydroazapetine retains significant ability to block alpha-adrenoreceptors and has been used as a ligand to study the receptor in a subcellular fraction containing membrane fragm... | 8,779 | [
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A comparison of the effects of flurazepam 30 mg and triazolam 0.5 mg on the sleep of insomniacs. | The effects of oral, bedtime triazolam 0.5 mg and flurazepam 30 mg, on the laboratory sleep of 12 insomniacs were compared in a double blind, crossover study. A 22 consecutive night schedule was used: Nts. 1--2 placebo; 3--6 first drug; 7--8 placebo; 9--14 no drugs; 15--16 placebo; 17--20 second drug; 21--22 placebo. I... | 8,813 | [
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Characteristics of pentobarbital discrimination in the gerbil: transfer and antagonism. | Experiment 1. Gerbils were trained in a T-shaped maze to discriminate the effects produced by pentobarbital (P-barb. 15 mg/kg, i.p.) and the effects of saline. The response, a left or right turn in the maze, was thus contingent upon the prevailing training condition (P-barb. or saline). The criterion of performing 8 co... | 8,815 | [
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A long-term study of benorylate in patients with rheumatoid arthritis. | The analgesic and anti-inflammatory efficacy and adverse effects of benorylate were studied over a period of 6 months in 33 patients suffering from definite or classical rheumatoid arthritis. The average dose used was 6 g daily and examinations were made before treatment and at regular intervals during treatment to ass... | 8,835 | [
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Non-adrenergic inhibition of the electrical activity of the antrum muscle fibers of the guinea-pig stomach. | The changes in the electrical activity of the antrum muscle fibers of the guinea pig stomach caused by ATP and its related compounds were compared with those caused by catecholamines. The antrum preparation exhibited spontaneous electrical activity and this was suppressed or inhibited by treatment with catecholamines (... | 8,859 | [
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Studies on new process procedures in plasma fractionation on an industrial scale. II. Experiments in concentrating dilute albumin solutions using hollow fiber ultrafiltration. | Ultrafiltration with a hollow fiber device was studied as an alternative method to the lyophilization or thin-layer distillation techniques in the production of salt-poor, concentrated human albumin preparations for clinical use. A number of process parameters are discussed. Combination of gel filtration and ultrafiltr... | 8,872 | [
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[Resistance against intra- and extracellular bacteria in experimentally aged rats (author's transl)]. | The authors study the cellular activity of RES against the microbes intracellular and extracellular parasites in rats with pronounced Progeria-like syndrome of Selye. RES of the experimentally aged animals copes, through with a certain delay, with the invading extracellular bacterium Diplococcus pneumoniae, but is utte... | 8,878 | [
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[Vetorial presentation of left-ventricular pressure parameters for the assessment of ventricular function]. | The ventricle function can be established by the vectorial description of left-ventricular pressure parameters or flow sizes, respectively. The vector diagrammes result from the momentaneous pressure within the ventricle on the X-axis and the differentiated pressure curve or the aortic flow, respectively, on the Y-axis... | 8,880 | [
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Liver enzymes in alcohol-discordant twins. | Seventy moderately alcohol-discordant male twin pairs have been investigated with respect to some liver enzymes. No differences were found as regards S-ALAT, while significantly higher enzyme levels were demonstrated for S-ASAT, S-ALP and S-GT among the high alcohol consumers compared to their low consuming co-twins. E... | 8,959 | [
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Development of Trypanosoma (Trypanozoon) brucei in Glossina morsitans inoculated into the tsetse haemocoel. | Classically, infective development of Trypanosoma (Trypanozoon) brucei in tsetse flies is thought to take the route crop-midgut-hindgut proventriculus-hypopharynx-salivary gland, where the parasites reach their infective phase. It has been shown experimentally that T. (T.) brucei is capable of developing up to the infe... | 8,974 | [
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[General survey of the present distribution of helminths in Iran and comparison with those of past years]. | In this paper the literature on helminthiasis in Iran is reviewed and the distribution, prevalence and intensity of infections caused by helminths are discussed. A comparison of prevalence and intensity of infections was accomplished in the recent 10 years by the author. Hookworm infections are found mostly in the nort... | 8,977 | [
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Acid-base changes in milk and blood of rats in acidosis and alkalosis. | Lactating white rats (Rattus norvegicus) were subjected to metabolic and respiratory acidosis and metabolic alkalosis. Before and during the various treatments, the acid-base status of heart blood and milk was determined. Acute metabolic acidosis lowered the pH of plasma and milk; Pco(2) and bicarbonate concentrations ... | 8,989 | [
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Interorgan transport of amino acids in hemorrhagic shock. | Arterial concentrations and net organ metabolism of amino acids (AA), O2, CO2, H+, and glucose (Glc) were measured in two dogs before and during hemorrhage and after blood replacement. Shock caused increased splanchnic and decreased peripheral blood flow and O2 consumption. Po2 decreased more in hepatic venous than in ... | 8,993 | [
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Protein chromatography on adsorbents with hydrophobic and ionic groups. Chromatography of dodecyl sulphate-solubilized proteins of the human erythrocyte membrane on N-(3-carboxypropionyl)aminodecyl-sepharose. | Human erythrocyte 'ghosts' were solubilized in 0.5% (w/v) sodium dodecyl sulphate at pH 4.0(I = 0.012 mol/I). At a loading of 1-2 mg of protein/ml of column volume, all of membrane proteins were adsorbed to a column of CPAD [N-(3-carboxypropionyl)-aminodecyl]-Sepharose at pH 4.0 (I = 0-012 mol/1) and room temperature (... | 9,064 | [
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0.3245066,
0.2678973,
0.2791962,
-0.1744... |
Kinetic analysis of the individual reductive steps catalyzed by beta-hydroxy-beta-methylglutaryl-coenzyme A reductase obtained from yeast. | The mechanism of action of yeast beta-hydroxy-beta-methylglutaryl-coenzyme A reductase has been investigated through kinetic studies on the oxidation of mevaldate by nicotinamide adeninine dinucleotide phosphate (NADP) in the presence of coenzyme A (CoA) and on the reduction of mevaldate by reduced NADP (NADPH) in the ... | 9,133 | [
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0... |
pH-sensitive glass microelectrodes and intracellular pH measurements. | 1. Some properties of the open-tipped, uninsulated, pH-sensitive glass microelectrode were examined in several electrical experiments. 2. Based on these observations, technical and theoretical problems were considered for application to the pH measurement in small cells. 3. The intracellular pH, (pH)i, of the epithelia... | 9,164 | [
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0.07729241,
0.3645016,
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0.2530684,
0.... |
Autolysis of Neisseria gonorrhoeae. Relation between mechanical stability and viability. | The relationship between the mechanical stability and the viability of N. gonorrhoeae (Type 4) in suspension was investigated. A correlation between viability and optical density recordings was often found. However, in spite of increased mechanical stability in solutions with low pH (5-2) or containing Cu++ or sucrose ... | 9,178 | [
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0.1974068,
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0.3890059,
0.01304788,... |
Isolation and characterization of isoenzymes of human salivary and pancreatic alpha-amylase. | Human salivary and pancreatic alpha-amylase (1,4-glucan 4-glucanohydrolase, EC 3.2.1.1) were separated by electrofocusing. In the first case we obtained six isoenzymes with isoelectric points of pH 5.70, 5.72, 6.23, 6.32, 6.73 and 6.88. Human pancreatic alpha-amylase has been separated into eight isoenzymes with isoele... | 9,210 | [
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0.1416624,
0.2271278,
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0.0... |
Photolysis of desmosine and isodesmosine by ultraviolet light. | 1. Desmosine and isodesmosine were separated by ion-exchange and paper chromatography, after acid hydrolysis of purified elastin from beef ligamentum nuchae. The fractions obtained by ion-exchange chromatography were clearly mixtures of related compounds. The desmosine fraction could be resolved into seven compounds an... | 9,274 | [
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The role of interchain disulphide bridges in the conformational stability of human immunoglobulin G1 subclass. Hydrogen-deuterium exchange studies. | The hydrogen-deuterium exchange data of human immunoglobulin G1 (IgG1) are interpreted by assuming fast fluctuations of the protein conformation, through which the peptide groups become exposed to the solvent. The probability of solvent exposure of peptide hydrogens reflects a rather loose conformation for native IgG i... | 9,279 | [
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0.004508381,
0.07376843,
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Hypoxia in fibroblast cultures. I. Changes in glucose consumption by 5 vol.-% oxygen concentration and reduced pH. | In secondary cultures of rat embryonic fibroblasts the glucose consumption and lactate concentration were comparatively investigated in 5 and 21 Vol.-% O2 environment at pH 6.6 and pH 7.4 (HEPES-buffer). The results were correlated with cell density. The following observations were made: 1. At pH 6.6 the rate of cell p... | 9,309 | [
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... |
[Polygraphic recording of sleep under the influence of Plantival plus]. | 10 patients with moderate non-psychotic sleep disturbances were investigated polygraphically for a total of 14 nights each. These 14 nights were subdivided into 4 test series: Placebo was given during the first, Plantival plus during the second and third and placebo again during the fourth series. The results showed th... | 9,347 | [
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... |
On the mechanism and some properties of vinylacetyl-CoA delta-isomerase of Clostridium kluyveri. | Vinylacetyl-CoA delta-isomerase from Clostridium kluyveri grown on ethanol/acetate was purified 32-fold. The enzyme is rather labile. All experiments were conducted with the substrate analog thioester of vinylacetic acid and N-acetylchysteamine (vinylacetyl-SEtNAc (1 f)). 3-Butinoyl-SEtNAc is a strong inhibitor of the ... | 9,349 | [
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A kallikrein-specific inhibitor in rat kidney tubules. | A kallikrein inhibitor was found in tubules of the rat kidney and purified by chromatography on Sephadex G-100. The molecular weight of the inhibitor, estimated by gel filtration and dodecylsulfate electrophoresis, is about 4700. It inhibits the following kallikreins: porcine submanidbular and pancreatic kallikrein, ra... | 9,350 | [
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Purification and properties of streptococcal hyaluronate lyase. | Hyaluronate lyase (hyaluronidase) has been purified and characterized from a group A type 4 Streptococcus. Production of the enzyme was favored by growth in trypsinized veal infusion in the presence of hyaluronate oligosaccharide and tetrasaccharide. Detectable enzymatic activity was diminished in the presence of N-ace... | 9,365 | [
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0.01214719,
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Hypnotic and minor tranquilizer use among inpatients and after discharge. | A major concern in prescribing hypnotics and minor tranquilizers in the hospital is that long-term habituation might develop. Former psychiatric inpatients were surveyed to assess hypnotic and minor tranquilizer use following discharge. Patients who used flurazepam and chloral hydrate as inpatients were no more likely ... | 9,366 | [
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On the mechanism of action of oligomycin and acidic uncouplers on proton translocation and energy transfer in "sonic" submitochondrial particles. | A study is presented of the effect of acidic uncouplers and oligomycin on energy-linked and passive proton translocation, oxidative phosphorylation, and energy-linked nicotinamide-adenine-nucleotide transhydrogenase in EDTA submitochondrial particles from beef-heart. A flow potentiometric technique has been applied to ... | 9,385 | [
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... |
Phosphofructokinase. I. Mechanism of the pH-dependent inactivation and reactivation of the rabbit muscle enzyme. | The kinetics of inactivation and reactivation of rabbit skeletal muscle phosphofructokinase have been studied as a function of pH and enzyme concentration at constant temperature in phosphate buffer. From the enzyme concentration dependence, we conclude that the minimal mechanism for inactivation involves a protonation... | 9,393 | [
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Latex agglutination in the diagnosis of pneumococcal infection. | A latex agglutination (LA) method for detection of pneumococcal antigens was evaluated and compared with counterimmunoelectrophoresis (CIE). LA was 2 to 10 times more sensitive than CIE for the detection of purified capsular polysaccharides in defined media, but only when a 1+ or 2+ agglutination reaction was interpret... | 9,422 | [
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Immune response to acute otitis media: association between middle ear fluid antibody and the clearing of clinical infection. | Clearing of the middle ear fluid in patients with acute otitis media due to Streptococcus pneumoniae or Haemophilus influenzae was significantly associated with the presence and concentration of specific antibody in the middle ear fluid at the time of diagnosis. | 9,424 | [
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Evaluation of the fetal state by automatic analysis of the heart rate. 2. Deceleration areas and umbilical artery blood pH. | Fetal heart rate (FHR) deceleration areas were studied to obtain by objective measurement of the FHR, their prognostic value of the new-born state. 1. There is a reasonably good correlation between FHR deceleration areas and UApH (Tab. II). Such a correlation was found by SHELLEY and TIPTON [6] for the whole decelerati... | 9,500 | [
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Clonidine and related analogues. Quantitative correlations. | Twenty-two structural derivatives of clonidine [2-(2,6-dichlorophenylimino)imidazolidine] have been synthesized and their main physicochemical parameters (log P, deltaRM, pKa) determined. Quantitative correlations between the peripheral alpha-mimetic action (pithed rats) and physicochemical parameters pointed out the c... | 9,510 | [
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... |
Alpha-adrenoceptor-mediated coronary artery spasm. | Selective coronary arteriography performed on a 41-year-old woman with angina pectoris demonstrated proximal stenosis of the right and left main coronary arteries that was unaffected by nitrate therapy. To exclude coronary artery spasm, the study was repeated, and a striking increase in the narrowing of the right coron... | 9,522 | [
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0.09349746,
0.1562446,
-0.058431... |
[In vitro antibacterial effects of spectinomycin and penicillin G on Neisseria gonorrhoeae singly and in combination (author's transl)]. | The antibacterial effects of spectinomycin and penicillin G on clinical isolates of Neisseria gonorrhoeae were studied. The concentrations of penicillin G at which the isolates showed drug sensitivity ranged widely from 0.011 to 6.25 mug/ml. Some of the isolates were resistant to penicillin G. Sensitivity to spectinomy... | 9,523 | [
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0.4210551,
0.835125,
0.0307037,
0.2808991,
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Absence of blocking effect of quinidine on responses to norepinephrine in the isolated dog atrium. | The isolated right dog atrium was perfused through the sinus node artery with blood led from a heparinized support dog under constant perfusion pressure of 100 mmHg. The positive chronotropic and inotropic responses to norepinephrine were not significantly suppressed by treatment with large amounts of quinidine or proc... | 9,524 | [
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Molecular sensory physiology of Euglena. | After a short description of the motile physiology of Euglena gracilis the responses to light stimulation are analyzed and a new nomenclature is proposed concerning flagellar motility variations. A discussion follows about the characteristics of the photoreceptive system of Euglena and about the flavinic nature of its ... | 9,595 | [
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0.1107161,
0.1871352,
0.3566793,
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[Changes in partial pressures of gases and of pH in the arterial blood of hypocapnic and hypercapnic subjects subjected to oxygen therapy]. | The behaviour of partial tensions of respiratory gases and pH in the arterial blood was evaluated in anoxiaemic and hypercapnic (1st group) and hypo-eucapnic (IInd group) subjects undergoing oxygen therapy. The following phenomena were observed: 1) normalization in paO2 values in both groups; 2) statistically significa... | 9,599 | [
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0.07056283,
0.09309095,
0.3458653,
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0.0630235... |
The reaction between thiols and 8-azidoadenosine derivatives. | Thiols react at room temperature in dilute solution with 8-azidoadenosine and its nucleotides to give the corresponding 8-aminoadenosine derivatives. The reaction which takes place in the dark is base-catalysed and is particularly rapid when dithiols, e.g. dithiothreitol are used. | 9,623 | [
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0.277911,
0.3569899,
0.008169165,
-0.2473708,
-0.049... |
Flurazepam ('Dalmane') in the treatment of insomnia in patients with respiratory disorders. | The effects on subjective aspects of sleep of flurazepam 15 mg and amylobarbitone sodium 100 mg were compared in insomniac patients with chest disease. A double-blind technique was used. The results indicate a significant superiority of flurazepam over the other drug. | 9,636 | [
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0.02490519,
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0.06739714,
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Implications of cross inhibitory interactions of potential mediators of hormone and neurotransmitter action. | Mediators of hormone and neurotransmitter action may exert negative control on the accumulation of one another (adenosine 3':5'-cyclic monophosphate, or conversely). A model in which one agonist stimulates the formation of two mediators which inhibit each other's accumulation has been simulated. Three types of agonist-... | 9,639 | [
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0.1997197,
0.347939,
0.05944966,
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... |
Supersaturation in sickle cell hemoglobin solutions. | The kinetic inhibition of the gelation of hemoglobin S is compared to the change in hemoglobin S soulbility, when the solubility is altered by carbon monoxide, pH, or urea. By means of a new technique, the delay time and the extent of gelation are measured on the same sample. They delay time, td, is found to be proport... | 9,640 | [
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0.250525,
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Bandage-backfall reaction: occurs in infancy, hypothalamic damage, and catalepsy. | In cataleptic clinging, produced either by catecholamine-blocking drugs or lateral hypothalamic damage in adult cats, rats, or monkeys, bandaging the face and neck causes the head to fall backwards. Early in development, a similar reaction can be seen in normal undrugged infants. | 9,643 | [
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[Practice and further development of the AMP-system (a report about a symposion and a seminar) (author's transl)]. | During two days in November 1974 TV-tapes of psychiatric interviews were demonstrated and the psychopathology was documented on AMP-record sheet 3. It was a purpose of the discussion to get stimulation for the improvement of the AMP-manual and to decrease the interrater-variance. It was only the first tape which was no... | 9,649 | [
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Treatment of phenothiazine-induced dyskinesia. | Previous experience indicated the possibility that a serotonin antagonist substance, was effective in relieving dyskinesia as a reaction to phenothiazine antipsychotic drugs. Since the substances used in the original observations did not become available on the United States market, a compound known to be a serotonin a... | 9,653 | [
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Effects of a novel anti-aggressive agent upon two types of brain stimulated emotional behavior. | The effects of anti-aggressive agent Sch 12679 were evaluated upon stable baselines of rage and predation elicited by electrical stimulation of the hypothalamus in cats. Sch 12679 depressed approach and terminal aspects of both forms of attack. This is consistent with previous reports, and suggests the drug is effectiv... | 9,658 | [
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Regulation of tyrosine and phenylalanine biosynthesis in Salmonella. | Several types of 4-fluorophenylalanine resistant mutants were isolated. In one type of mutant DAHP synthetase (tyr) and prephenate dehydrogenase were coordinately derepressed. The mutation was linked to aroF and tyrA and was cis- dominant by merodiploid analysis, thus confirming that it is an operator constitutive muta... | 9,783 | [
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Interference stimulated by tick-borne encephalitis virus: influence of divalent cations. | The effects of divalent cations (barium, cobalt, calcium, copper, magnesium, zinc and iron) on the interference of tick-borne encephalitis (TE) virus with vaccinia virus in Detroit-6 cell cultures were investigated. An increase in interference was shown in the presence of cobalt, zinc, copper, and magnesium. Barium and... | 9,799 | [
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Infection of Hela cells with a virulent and an attenuated strain of pseudorabies virus studied by electron microscopy. | Hollow-core particles, forming crystals in nuclei, prevailed in HeLa cells infected with an attenuated strain of pseudorabies virus (PRV). After infection with a virulent PRV strain, the cells contained mainly fully infectious dense-core particles. These findings might explain the lower susceptibility of HeLa and some ... | 9,806 | [
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Replication dynamics of tick-borne encephalitis virus in, and glycolytic activity of, human diploid cells. | Tick-borne encephalitis (TBE) virus (Western subtype) strains replicated very rapidly in human diploid embryonic lung (HDEL) cells, namely within the first 24 hours of infection. Greater amounts of both intra- and extracellular virus were produced after inoculation of a virulent than of an attenuated strain. With the v... | 9,821 | [
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A diagram to facilitate the understanding and therapy of mixed acid base disorders. | A diagram based on in-vivo relationships between arterial hydrogen ion activity (H+) and carbon dioxide tension (PCO2) in primary abnormalities of acid base homeostasis is presented. It is designed to facilitate the interpretation of pH data by including the 95% confidence limits described in patients with simple metab... | 9,841 | [
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[Pulmonary edemas of infectious origin]. | Diffuse pulmonary edema, capable of arising in the absence of hemodynamic disorders is rare in infectious disease. They take on two different clinical appearances: a) acute edema of the lung with the syndrome of asphysia, b) a subacute dyspneic pneumonia with hypoxemia and hypo or normocapnia. These initial disorders c... | 9,855 | [
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[Pulmonary water and thoracic impedance. Evaluation of a measurement technic]. | We measured transthoracic electrical impedance in 17 anesthetized and mechanically ventilated dogs with a four-electrode system. A current (5 KHZ, 50 mu A) is injected and detected at axillary levels. Transthoracic impedance was 67 +/- 14 ohms (S.D.) with insignificant shifts in control animals. Pulmonary edemas were i... | 9,860 | [
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[Corticoids in respiratory pathology]. | After briefly recalling the action of corticosteroids on the normal and pathological lung, the authors review the different etiologies where they can be used in respiratory pathology. | 9,881 | [
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[Immunological aspects of corticotherapy]. | The therapeutic effectiveness of corticoids in transplantation, in autoimmune conditions and in numerous diseases in which the pathogenic role of hypersensitivity reactions is invoked, is perfectly established on the empirical basis of clinical cases. The study of the effects of corticoids on the immunological response... | 9,882 | [
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[Corticoids and shock]. | After recalling the major role of catecholamines in the genesis of irreversible shock, the anti-shock action of glucocorticosteroids, owing to properties which are "alpha-blocking" , is discussed in this work. The works of LILLEHEI on the effectiveness of corticosteroids in different types of shock are summarized and d... | 9,884 | [
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[On the ecology of marine chromatiaceae and chlorobiaceae (author's transl)]. | Number and genera (types) of phototrophic red and green sulfur bacteria have been determined in the upper layer of eleven marine sediment samples from the euphotic zone in the Mediterranean Sea. Origin and nature of the sediment samples are given as well as their pH, total nitrogen and sulfide content. The results show... | 9,896 | [
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[Alterations of cat papillary muscle mechanics induced by changes of preload under variation of physical and chemical parameters (author's transl)]. | A rapid change in length of cat papillary muscle induces two reciprocal diastolic and systolic processes: stretching causes a viscoelastic relaxation of the muscle. The opposite behavior is observed after abrupt releases when - subsequent to an increase in resting tension - diastolic force attains its new equilibrium. ... | 9,930 | [
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Adaptations of enzymes for regulation of catalytic function. | 1. Enzymes must not only be extremely effective catalysts, but must also be the operating components of very sensitive and sophisticated regulatory systems. Appropriate evolutionary adjustment of the properties of different enzymes causes the sites that bind typical metabolic intermediates to be only partially saturate... | 9,941 | [
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Mung bean nuclease I. Physical, chemical, and catalytic properties. | A simplified purification procedure for mung bean nuclease has been developed yielding a stable enzyme that is homogeneous in regards to shape and size. The nuclease is a glycoprotein consisting of 29% carbohydrate by weight. It has a molecular weight of 39 000 as determined by polyacrylamide gel electrophoresis in the... | 9,973 | [
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Regulatory properties of the pyridine nucleotide transhydrogenase from Pseudomonas aeruginosa. Kinetic studies and fluorescence titration. | Mechanisms involved in the action of the pyridine nucleotide transhydrogenase from Pseudomonas aeruginosa (EC 1.6.1.1) have been investigated by means of kinetic studies and fluorescence titration. Our results, as well as those from previous investigations, suggest that the allosteric MWC model (Monod, J., Wyman, J., a... | 9,983 | [
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Studies on phenylalanine and tyrosine hydroxylation by rat brain tyrosine hydroxylase. | Tyrosine hydroxylase (EC1.14.16.2), presumably the rate-limiting enzyme in the biosynthesis of catecholamines, is known to catalyze the hydroxylation of both phenylalanine and tyrosine. Using both an isolated enzyme preparation and a synaptosomal preparation, where some architectural integrity of the tissue has been pr... | 9,989 | [
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Microheterogeneity of arylsulfatase A from human tissues. | Human arylsulfatase A (cerebroside-3-sulfate 3-sulfohydrolase, EC 3.1.6.8) exhibited microheterogeneity on isoelectric focusing in polyacrylamide gels. Pure urinary enzyme gave 3 bands of activity with pI values of 4.7, 4.8 and 4.9, whereas purified liver enzyme yielded six equally spaced bands from pI 4.4 to 4.9. Dete... | 9,992 | [
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Photocontrol of urease activity in spiropyran collagen membrane. | 1. Collagen fibrils were modified with beta-1-[3,3-dimethyl-6'-nitrospiro-(indoline-2,2'-2H-benzopyran)] propionic anhydride. 2. Urease (urea amidohydrolase, EC 3.5.1.5) was immobilized in spiropyran collagen membrane. The activity of the urease-spiropyran collagen membrane was found to increase in the dark and then de... | 9,996 | [
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Study of the biological significance of cytochrome methylation. I. Thermal, acid and guanidinium hydrochloride denaturations of baker's yeast ferricytochromes c. | The iso-cytochromes c from baker's yeast: iso-1 methylated and unmethylated forms and iso-2 have been purified and their stabilities towards denaturants compared to that of horse heart cytochrome c. Thermal, acid and guanidinium hydrochloride denaturations were followed using fluorescence emission of their tryptophan 5... | 10,001 | [
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Distinct testicular 17-ketosteroid reductases, one in interstitial tissue and one in seminiferous tubules. Differential modulation by testosterone and metabolites of testosterone. | The final step in the biosynthesis of testosterone is the reduction of androstenedione, which is catalyzed by the microsomal enzyme 17-ketosteroid reductase. Evidence is presented which suggests that there are two distinct 17-ketosteroid reductases in rat testes, one in interstitial tissue and one in seminiferous tubul... | 10,012 | [
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The chemical ecology of Biomphalaria glabrata: the effects of ammonia on the growth rate of juvenile snails. | When juvenile specimens of Biomphalaria glabrata were subjected to concentrations of ammonia ranging from 1-100 mug/ml in various media the following effects were observed: the addition of ammonia to borate buffered media caused mortality. Both borate and tris-buffered media caused a decrease in the growth rate of snai... | 10,014 | [
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0.5173661,
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Fresh symptom emergence after intensive behaviour therapy. | The outcome of a standard four-day intensive symptomatic treatment programme with 39 agoraphobics is examined in relation to the incidence of fresh symptom emergence. Twenty-six patients suffered fresh symptom emergence during follow-up, and there was a significant association of fresh symptom emergence with poorer out... | 10,038 | [
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Production of volatiles from decomposing plant tissues and effect of these volatiles on Rhizoctonia solani in culture. | Volatiles, of which NH3 is a major component, were evolved from decomposing immature corn tissue (c:n9) and affected R. solani in culture two ways: they supplied additional nitrogen to the growth medium so that fungal mycelial growth increased; and they raised substrate pH from 5.5 to 8.2 which induced melanization of ... | 10,069 | [
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Psychotropic drug use among women. | The consistent 2:1 ratio of women to men in the receipt of prescriptions for psychotropic drugs is reflected in the higher rates for women of neurotic illness, symptoms of both physical and mental discomfort, and help-seeking and drug-taking behaviour. Physicians' perceptions of the problems presented by their male and... | 10,075 | [
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-0.2949724,
0.358061,
-0.09302629,
-0.07034722,
-0.09096076,
0.1984626,
-0.25... |
Adoptive immunotherapy of a Gross virus producing lymphoma and a methylcholanthrene-induced fibrosarcoma in tolerant rats. | Immunological tolerance to Gross virus-specific transplantation antigens in rats given neonatae transfer of donor lymphoid cells beneath the kidney capsule of syngeneic recipient rats. Immune or normal donor cells invariably developed a cell-mediated immune reaction in kidneys of GV-tolerant recipients, presumably agai... | 10,076 | [
0.003954258,
-0.1167732,
-0.06896595,
-0.2597055,
0.2126014,
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0.2091466,
0.3434331,
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0.06661341,
0.08638263,
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0.0946724,
0.1386942,
0.367148,
0.4280929,
0.1955271,
-0.2091335,
... |
Isolation and identification of benzodiazepine drugs and their metabolites in urine by use of Amberlite XAD-2 resin and thin-layer chromatography. | We used the method described here to detect and identify seven benzodiazepine derivatives--diazepam, chlorodiazepoxide, nitrazepam, cloxazolam, oxazolam, oxazepam, and medazepam--and their metabolites in the urine of rabbits given the seven drugs orally. We column-chromatographed 25-ml samples of urine on Amberlite XAD... | 10,093 | [
-0.07401101,
0.6417524,
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0.03129362,
0.2323183,
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0.309829,
0.05279829,
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0.345939,
0.3001447,
0.3068348,
0.2815205,
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0.2667988,
0.3818657,
0.03937498,
0.3497346,
0.1557573,
-0.1239512,
0.05192... |
Characterization of adenosine deaminase isozymes from normal human erythrocytes. | Adenosine deaminase of phenotype ADA was partially purified by chromatography on CM-Sephadex C-50 and ammonium sulphate precipitation. With DEAE-Sephadex A-50 three isozymes could be detected. a. The KM values for the substrate adenosine were found to be 30 muM for each isozyme. b. pH optimum was 7.0 and the molecular ... | 10,102 | [
-0.0173345,
0.09382984,
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0.2546253,
0.0677241,
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0.09310604,
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0.2598031,
0.3867378,
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0.4552588,
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0.2647809,
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0.09912845,
0.132029,
0.3208934,
0.7779646,
0.07439821,
-0.1210726,
0.083... |
Effect of sulfasalazine on digoxin bioavailability. | Low levels of digoxin were noted in a patient receiving digoxin and sulfasalazine (SSA). Discontinuation of SSA resulted in a significant increase in serum digoxin levels. To determine whether or not SSA consistently interfered with the therapeutic effect of digoxin, both drugs were administered to 10 normal subjects i... | 10,123 | [
-0.2918221,
0.05711828,
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0.05242806,
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0.1156139,
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0.188435,
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0.03590884,
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0.1117807,
0.01323226,
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... |
The influence of beta-adrenoceptor antagonists on accommodation of the lens. | 1. A study of the influence of single oral doses of the adrenergic-beta-receptor anatagonists alprenolol (100 mg) and propranolol (50 mg) on the accommodation of the lens was made in six healthy male subjects. 2. There was no significant influence of either drug on lens accommodation. | 10,118 | [
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0.05877878,
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0.002811113,
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0.0772889,
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0.01009949,
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0.2604702,
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0.1834361,
0.1174336,
0.3798406,
-0.003774495,
0... |
Pharmacokinetics of oxprenolol in normal subjects. | The effect of oxprenolol administered intravenously (10 and 20 mg) and orally (20, 40, 80, and 160 mg) on plasma concentrations of the drug, resting heart rate, exercise-induced tachycardia, and arterial blood pressure was assessed as a function of time in 6 healthy subjects. The pharmacokinetics of oxprenolol followin... | 10,124 | [
-0.2487369,
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0.2568405,
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0.04374014,
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0.03182103,
0.1018218,
0.1790187,
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0.524501,
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... |
Intrarenal arterial aneurysms. | Intraparenchymal renal aneurysms have been reported with increasing frequency; yet, to our knowledge, this subject has not been reviewed in radiologic literature. The spectrum of such aneurysms includes congenital aneurysms, those secondary to disease usually affecting the main renal arteries, those associated with ren... | 10,134 | [
-0.4096434,
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0.05434417,
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0.1962269,
0.1090071,
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0.09625828,
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-0.3220554,
0.2405991,
0.1434987,
-0.1197842,
-0.03725811,
-0.004586309,
-0.12... |
Efficiency of oxidative phosphorylation and energy dissipation by H+ ion recycling in rat-liver mitochondrial metabolizing pyruvate. | A method was developed for the calculation of metabolic fluxes through individual enzymatic reactions of pyruvate metabolism including the citric acid cycle in rat liver mitochondrial incubated at metabolic states between state 4 and state 3. This method is based on the measurement of the specific radioactivities of th... | 10,160 | [
-0.1356407,
0.2627418,
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0.3077461,
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0.1106033,
0.2410543,
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0.035059,
0.03259708,
0.1345959,
0.2438752,
0.06253326,
0.3009169,
0.... |
Plasma and brain amino acids in fulminant hepatic failure and their relationship to hepatic encephalopathy. | Amino acid concentrations were determined in plasma, whole blood, cerebrospinal fluid and brain tissue of 45 patients with grade 3 or 4 coma due to fulminant hepatic failure. The concentration of 15 of the 19 amino acids determined were significantly increased in blood and the increases were greatest for the amino acid... | 10,164 | [
-0.1505427,
0.07227565,
0.1663002,
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0.2659093,
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0.2288183,
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0.2110813,
0.1296117,
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0.5548112,
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0.02592297,
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0.2663642,
0.01766979,
0.1307687,
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0.1843738,
0.06783725,
... |
Regulation of enzymes of ethanol metabolism in yeast (Rhodotorula gracilis). | The three enzymes of ethanol metabolism alcohol dehydrogenase, aldehyde dehydrogenase and acetyl-CoA synthetase in the obligate aerobic yeast Rhodotorula gracilis are repressed by glucose and induced by C2 metabolic fuels with a regulatory pattern indicating a correlation in the control mechanisms. To try an identifica... | 10,176 | [
0.0602114,
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0.2102415,
0.123995,
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0.173534,
0.3530721,
0.323054,
-0.04079837,
-0.... |
Salycylamide glucuronide formation in liver disease and its change by drugs. | Salicylamide glucuronide (SAMG) in 0-6 and 6-12 hours-urine specimens was determined after oral administration of salicylamide in 7 normal volunteers (NV), in 51 cases of various liver diseases and hyperbilirubinemias, and in 19 cases after drug administration, to predict the in vivo drug metabolism in man and its chan... | 10,219 | [
-0.07382371,
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0.4529189,
0.1513601,
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0.191259,
0.2772301,
0.4095752,
0.2764524,
0.3025243,
-0.04340522,
... |
[Action mechanisms of the contracting drugs, K, acetylcholine, histamine and Ba and of the antispasmodics, isoproterenol and papaverine in the isolated guinea pig ileum, particularly in relation to Ca]. | Shapes of the contractions induced by K, acetylcholine (AHc), histamine and Ba consisted of the phasic contraction (PC) and the subsequent tonic contraction (TC). PCs by K, ACh and histamine are initiated by the release and the passive influx of Ca, whereas that by Ba is only initiated by the release of Ca. TCs by K, A... | 10,235 | [
0.034664,
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0.330381,
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0.1834818,
0.2348563,
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0.08625672,
0.04247986,
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0.2289246,
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-0.95714,
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0.1103644,
-0.03712188,
0.4267965,
0.09957127,
0.06036692,
-0... |
Effect of hypophysectomy and insulin on lipogenesis in cockerels. | Hypophysectomy increases hepatic lipogenesis in cockerels. In an attempt to find the possible hormonal mechanism for this we have examined the effects of hypophysectomy, insulin and pituitary homogenates on hepatic lipogenesis. Insulin (5 U/kg) injected intravenously, simultaneously with glucose-14C tracer, increased t... | 10,239 | [
0.2917451,
-0.4147584,
-0.02185861,
0.05907341,
0.04478422,
-0.1602712,
-0.2296389,
0.3051099,
0.007880587,
0.2886541,
0.2217279,
0.1003591,
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0.05550141,
-0.3100229,
0.03889054,
-0.04143194,
0.4088581,
0.2342597,
0.218922,
0.05791071,
... |
Cardiac myosin from pig heart ventricle. Purification and enzymatic properties. | A method is described for the preparation of high purity myosin from the left ventricle of pig heart. The purified myosin was free from nucleic acid, actin, tropomyosin, troponin, the 150,000 molecular weight protein and other contaminants. Analyses of subunits in the purified myosin were carried out on 3.5% acrylamide... | 10,292 | [
-0.3574871,
0.2102288,
-0.2660448,
-0.1465118,
0.2404552,
-0.1409428,
-0.2137195,
0.3054642,
0.1328882,
0.1686712,
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0.263142,
0.09883668,
0.1042315,
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0.2060177,
-0.5185331,
-0.03960541,
0.2853996,
0.2217982,
0.4489988,
0.1332056,
-0.3720131,
0.330... |
Quantitative aspects of relationship between glucose 6-phosphate transport and hydrolysis for liver microsomal glucose-6-phosphatase system. Selective thermal inactivation of catalytic component in situ at acid pH. | Studies of the thermal stability of rat liver glucose-6-phosphatase (EC 3.1.3.9) were carried out to further elevate the proposal that the enzymic activity is the result of the coupling of a glucose-6-P-specific translocase and a nonspecific phosphohydrolase-phosphotransferase. Inactivation was observed when micorsomes... | 10,305 | [
0.02612235,
-0.1316537,
-0.2966235,
0.01227279,
0.03011156,
-0.492743,
-0.0398691,
0.3387266,
0.1512638,
0.02900265,
0.1263198,
-0.2795374,
0.01637013,
0.06810831,
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0.3112212,
-0.2565128,
-0.05043605,
-0.04108404,
0.2095641,
0.1989862,
0.01016902,
0.0824378,
... |
The occurrence of salmonellas, mycobacteria and pathogenic strains of Escherichia coli in pig slurry. | Ninety-eight samples of pig slurry from 54 farms were examined for the presence of salmonellas, porcine enteropathogenic strains of haemolytic Escherichia coli and mycobacteria. Salmonellas were isolated from 12 farms (22%) and enteropathogenic E. coli from 13 farms (24%). Pathogenic mycobacteria were not isolated. Sal... | 10,332 | [
-0.417661,
0.1310956,
0.3832057,
0.001360085,
-0.2209733,
-0.2890533,
-0.3377327,
-0.06839729,
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-0.4279573,
0.1288684,
-0.08615311,
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0.2100653,
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0.08228686,
-0.5625327,
-0.07486009,
0.1455257,
0.04128625,
0.1219966,
0.3294935,
-0.00498663... |
Nitrogen intake and tumorigenesis in rats injected with 1,2-dimethylhydrazine. | Tumor incidence was studied in 1,2-dimethylhydrazine (DMH) injected male rats assigned at weaning to isoenergetic casein-sucorse deits containing 7.5%, 15%, or 22.5% protein with or without 2.5% urea. Twenty rats fed each diet were given weekly intraperitoneal injections of DMH (15 mg/kg body weight/week) for the first... | 10,359 | [
-0.4151484,
-0.4096591,
-0.2423596,
-0.06660461,
0.1381134,
-0.6783379,
0.03248662,
0.1988824,
0.06837676,
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0.1276235,
0.06968066,
-0.01463239,
0.2389464,
-0.134... |
Interactions of bradykinin, prostaglandin E1, 5-hydroxytryptamine, histamine and adenosine-5'-triphosphate on the dry leakage response in rat skin. | Dye leakage in rats produced by intracutaneous injections of irritants was quantitated using an azovan blue technique. Concentration-response lines were obtained for irritants alone and in presence of constant concentrations of other irritants. 5-Hydroxytryptamine (5-HT) (10-7M) potentiated histamine, bradykinin and pr... | 10,368 | [
-0.1644486,
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0.2275239,
0.06181667,
0.05389964,
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0.1316418,
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0.2243127,
0.07750557,
0.123861,
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0.02157809,
-0.20435,
-0.08092555,
0.1083203,
0.05628728,
0.1264347,
0.... |
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