title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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A new class of irreversible muscarinic antagonists: beta-haloethylamine furoates. | The synthesis of a class of ultra-long acting muscarinic antagonists is described. Furthermore, it is noted that the stability of the, in situ, aziridinium ion is sufficiently great so that these agents can be used to study the effect of temperature upon the conformation of the muscarinic cholinoceptor. The inactivatio... | 10,393 | [
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Data point weighting in pharmacokinetic analysis: intravenous paracetamol in man. | Compartmental analysis of plasma paracetamol concentrations following intravenous injection of 12 mg kg-1 in aqueous solution to normal subjects was performed using analogue and digital computer methods. Using a "simplex" non-linear optimization procedure, the pharmacokinetic parameters were found to be influenced cons... | 10,395 | [
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Liquid chromatography in pharmaceutical analysis V: determination of an isoniazid-pyridoxine hydrochloride mixture. | Operating parameters are described for the qualitative and quantitative analysis of an isoniazid-pyridoxine hydrochloride mixture by high-pressure liquid chromatography. Each compound was chromatographed on an octadecyl column, using absolute methanol-water (60:40) (pH 2.5) containing 0.01 M dioctyl sodium sulfosuccina... | 10,409 | [
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Loperamide binding to opiate receptor sites of brain and myenteric plexus. | Loperamide, a new antidiarrheal agent, was tested to determine whether its biological activity involves binding to opiate receptor sites. Loperamide and morphine competitively inhibited 3H-naloxone binding to homogenates a guinea-pig brain and myenteric plexus. The Kp values obtain in the presence of Na+ were: morphine... | 10,422 | [
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Exonuclease associated with bacteriophage T5-Induced DNA polymerase. | T-5-induced DNA polymerase has been shown to possess a 3' leads to 5'-exonucleolytic activity. The exonuclease acts on both native and denatured DNA, but the apparent rate of degradation of denatured DNA is about five times faster than that for native DNA. The enzyme appears to act only on 3'-OH ends and produces mainl... | 10,451 | [
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Structural proteins of polyoma virus: proteolytic degradation of virion proteins by exogenous and by virion-associated proteases. | A model has previously been proposed for the genetic relatedness of the structural proteins of polyoma virus, based upon similarities in the peptide maps of the major capsid protein VP1 with the virion proteins VP2 and VP3. Newer evidence suggests that this model is incorrect, and that protein VP1 is a product of one v... | 10,452 | [
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A new analgesic testing method using ultrasonic stimulation. I. Effects of narcotic and nonnarcotic analgesics. | A quantitative method for measuring pain threshold by the use of ultrasonic stimulation in mice has been designed. The method had the advantage of precision, simplicity of technique, rapidity of measurement, and the fact that the stimuli is innocuous upon repeated application. The nature of the senstaions induced by ul... | 10,456 | [
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HLA antigens in arterial occlusive diseases in Japan. | Using a NIH standard lymphocytotoxicity test, a possible Japanese specific HLA antigen, HLA-BJW 22.2 was identified in 17 out of 48 patients with thromboangiitis obliterans (35.4 per cent), in 5 out of 15 patients with Takayasu's arteritis (33.3 per cent) and in 11 out of 113 normal controls (9.7 per cent). On the othe... | 10,460 | [
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[Hypoxia and polytrauma]. | The importance of polytrauma and hypoxia, resp., is discussed by the authors with regard to the mortality and the common effect of these is analysed. It was found that in the mortality of the patients suffered polytraumatism the first place (59,4%) is taken by such lesions, in which simultaneous lesion of the skull and... | 10,478 | [
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[Classification and diagnosis of ankle injuries]. | A new method for the classification of the injuries of the ankle is recommended by the author. The main types according to his classifixation are the following: pronation-flexion, pronation-extension, supination-extension, supination-flexion and supination-extension types. His classification is compared with Lauge-Hans... | 10,479 | [
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Triacetylated insulin: biologic activity and resistance to degradation. | Tritiated N-hydroxysuccinimide acetate was prepared with specific activities up to 5 Ci/mmole and utilized to prepare tritiated triacetyl insulin. Binding of triacetyl insulin to liver plasma membranes was measured by its capacity to displace 125I-monoiodoinsulin. At low concentrations, less than 10 ng/ml triacetyl ins... | 10,504 | [
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Effect of hydrogen ion buffers on photosynthetic oxygen evolution in the blue-green alga, Agmenellum quadruplicatum. | The photosynthetic oxygen evolution capacity of Agmenelium quadruplication suspended in four hydrogen ion buffers (pH 7.4, 0.05 M) and its synthetic marine growth medium was measured with an oxygen electrode. High rates of oxygen evolution were obtained in the growth medium and N-tris(hydroxymethyl)-methylglycine (Tric... | 10,506 | [
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Biochemical properties of the prostaglandin/thromboxane synthetase of human blood platelets and comparison with the synthetase of bovine seminal vesicles. | The enzyme system which synthesizes prostaglandins and thromboxanes in extracts of washed human platelets has been characterized with respect to kinetic parameters, pH and cofactor dependence, and inhibitor potencies. Arachidonate and dihomo-gamma-linolenate were shown to be mutually competitive substrates, thus provi... | 10,602 | [
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[The Göttinger minipig as a laboratory animal (author's transl)]. | Blood pictures, serumelectrolytes, acid-base- and bloodgas-values of the arterial blood were determined from two juvenile and one adulte collectives of minipigs (Gottingen strain), which were kept under SPF-conditions. The results were compared with the corresponding values of human blood and should be regarded as base... | 10,610 | [
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Carbonic anhydrase inhibitor in trout plasma. | A manometric assay has been constructed such that carbonic anhydrase dehydration activity can be determined utilizing intact erythrocytes. It was found that unwashed whole trout blood lacks any dehydration activity quite in contrast to whole rat blood. Removal of the plasma and replacement with physiological saline res... | 10,613 | [
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Structural studies on des-pentapeptide (B26-30)-insulin. V. High resolution NMR studies. | Preliminary studies have been made of the 250 MHz nuclear magnetic resonance spectra of both insulin and DPI. Differences have been found between DPI and insulin spectra, which indicate that the splitting off of the B-chain C-terminal pentapeptide from insulin has brought about local changes in the conformation of the ... | 10,624 | [
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[Hydrogen ion activity in the cell]. | Literature data and results of our experiments evidence for a heterogenous hydrogen distribution in cells. Intracellular pH should be regarded as a mean activity of hydrogen ions which is the sum of activities in different phases of a cell. Intracellular pH value does not depend on the transmembrane action potential di... | 10,657 | [
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[Activity and variability of aminopeptidases and gamma-glutamyl transpeptidase of the cutaneous mucous membrane in the cow's rumen]. | The authors studied the activity, chromatographic and electrophoretic distribution of leucylarylamidase, cystinamino peptidase, and gamma-glutamyl transpeptidase of the cytoplasmatic fraction of cow's rumen mucous membrane homogenate. The results of comparative analysis draw attention to the existence of a certain numb... | 10,665 | [
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[Cleavage of alpha-L-arabinofuranoside, beta-D-glucopyranoside and beta-cellobioside of 4-nitrophenol by enzymes of various fungi - a contribution to increase the selectivity of tumor therapy]. | To carry out long-term experiments as part of a therapy concept of malignant tumours using inactive transport forms of cancerostatic substances and their specific cleavage in the acidic pH region of the tumours by application of extraneous enzymes, we require enzymes with similar catalytic and pharmacokinetic propertie... | 10,689 | [
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[Different deoxyribonuclease-activities in bull seminal plasma (author's transl)]. | By means of the in situ assay of deoxyribonucleases in DNA-containing polyacrylamide gels after separation by micro-disc-electrophoresis different deoxyribonucleases are detectable in bull seminal plasma. There are two groups of acid deoxyribonuclease-activities with a pH optimum at pH 5.0, one with a pH optimum at pH ... | 10,693 | [
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[Etiopathogenesis of necrotizing arteritis (leukocytoclastic vasculitis)]. | The small vessel's necrotizing angiitis (necrotizing microangiitis (NMA), leucocytoclastic angiitis) form a continuous spectrum from the exclusively cutaneous forms of Gougreot, to those which seriously affect the viscera, as the very acute and fatal cases of Zeek, passing through a series of intermediate phases, in wh... | 10,721 | [
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Controlled trial of fetal intensive care. | A fetal intensive care unit was formed at the Queen Victoria Memorial Hospital in 1972. Because of some doubt concerning the value of fetal intensive care, a controlled clinical trial including all high-risk patients was performed. The trial clearly showed that intensive care is associated with improved neurologic and ... | 10,731 | [
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[Anaphylactic shock to pentothal induction]. | In a patient who had been anaesthetised twice with penthiobarbitone, who had contracted a localised then a generalised eczema, collapse appeared during a third anaesthetic induction, 30 minutes after the injection of penthiobarbitone which was revealed by Shelley's test to be the most positive product. | 10,761 | [
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[Allergy and anesthesia: environment and psychological factors]. | The assessment of so-called risk "carriers" is difficult from the standpoint of true allergy and consideration must be given to the following:- the psychology and environment of the patient to be anaesthesia, with regard to any warning signs. -also, though, the psychology and environment of the anaesthetist; himself al... | 10,766 | [
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[Determination of serum IgE]. | After recalling the properties of IgE antibodies responsible for allergic reactions, the author looks at the methods of assay by the techniques of radial immunodiffusion and radio-immunology. The total serum IgE of 13 subjects who had had an anaphylactic accident during anaesthesia, were assayed according to the latter... | 10,770 | [
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[Does anesthesia have an immunosuppressive effect?]. | Immune depression occurs after general anaesthesia. It is related to depression of serum factors after anesthesia with ether or chloroform, or secondary to depression of antibody-producing cells after anaesthesia with halothane, nitrous oxyde or Pentothal. This immune depression augments proneness to bacterial and vira... | 10,775 | [
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[Antigenicity of drugs used in anesthesiology]. | The authors studies the factors involved in the antigenicity of the principal medications used in anaesthetics, including general anaesthesia, local anaesthetics and muscle relaxants. Any attempt at establishing a correlation between the chemical properties of these medications and their haptenic power would seem diffi... | 10,785 | [
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[Plasma level of the thiocyanate ion in sodium nitroprusside perfusion]. | 24 subjects were selected at random out of a group of 80 patients undergoing surgery under a hypotensive anaesthetic technique by means of nitroprusside perfusion; the variation of one of the metabolites, the thiocyanide ion, were assayed. Hypotension was of 30 to 380 minutes duration and mean dosage of 12,44 mg (1,99 ... | 10,791 | [
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0.4283805,
0.3546746,
0.2716814,
0.2905061,
0.06420869,
... |
[Problems presented by closed laryngeal-tracheal injuries]. | The authors consider the problems raised by severe closed laryngotracheal trauma and report 4 cases. -the immediate tisk to life is due to direct involvement of the respiratory tract requiring emergency measures including cardiorespiratory resuscitation in cases of acute asphyxia. -the origin of the initial respiratory... | 10,813 | [
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[Personal experience with anesthesia of ambulatory patients operated on in odontostomatological offices]. | The authors report their experience of anaesthesia of ambulatory patients operated on in dental surgeries; the authors review safety factors, specially, choice of material, drugs and techniques which seem to them essential. They expose in detail their personal techniques, in particular, nasotracheal intubation and open... | 10,817 | [
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0.2793066,
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Effects of lithium and rubidium on antinociception and behaviour in mice. I. Studies on narcotic analgesics and antagonists. | The effects of acute and chronic LiCl and RbCl treatments on the antinociception caused by morphine, pethidine, methadone, pentazocine, nalorphine or naloxone were studied in mice using the hot plate and phenylquinone writhing tests. In both tests morphine, pethidine, and methadone caused significant antinociception wh... | 10,866 | [
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Evaluation of intrinsic sympathomimetic activity of beta-adrenoceptor blocking drugs in the treatment of patients with angina pectoris. | Beta-adrenoceptor blocking drugs with intrinsic sympathomimetic activity (ISA) may be less effective in the treatment of patients with angina pectoris than some others that lack this property. A review of 14 trials comparing beta-adrenoceptor blocking drug with ISA and those without ISA in angina pectoris has been made... | 10,882 | [
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... |
Characterization of hemoglobin Burke [beta 107 (G9) Gly replaced by Arg]. | Hb Burke [beta 107 (G9) Gly replaced by Arg] was discovered in a young woman with hemolytic anemia. A substitution in this position has not been previously reported either in the human beta-chain or in any of the animal beta-chains so far sequenced. The abnormal hemoglobin shows heat instability and a lowered oxygen af... | 10,883 | [
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Identification and properties of the covalently bound flavin of beta-cyclopiazonate oxidocyclase. | Beta-Cyclopiazonate oxidocyclase from Penicillium cyclopium has been previously shown to contain flavin dinucleotide in covalent linkage to the protein. In the present study, a pure flavin mononucleotide peptide was isolated from the enzyme by tryptic-chymotryptic digestion, chromatography on Florisil and on diethylami... | 10,963 | [
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A simple, quantitative approach to the coupling of photophosphorylation to electron flow in terms of proton fluxes. | A simple relationship between observed phosphorylation efficiencies (P/e ratios) and internal proton concentration in spinach chloroplast thylakoids has been derived. P/e ratios, varked by either changing the light intensity or by adding the energy transfer inhibitor, 4'-deoxyphlorizin, were found to change with intern... | 10,966 | [
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Properties and subcellular distribution of guanylate cyclase activity in rat renal medulla: correlation with tissue content of guanosine 3',5'-monophosphate. | The properties of the guanylate cyclase systems of outer and inner medulla of rat kidney were examined and compared with those of the renal cortex. A gradation in steady-state cyclic guanosine 3',5'-monophosphate (cGMP) levels was observed in incubated slices of these tissues (inner medula greater than outer medulla gr... | 10,967 | [
-0.2562744,
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0.2417515,
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0.12... |
Properties and subcellular localization of CMP-N-acetylneuraminic acid hydrolase of calf kidney. | The properties and subcellular distribution of CMP-N-acetylneuraminic acid (CMP-NAcNeu) hydrolase were studied in the cortex of calf kidney. The pH optimum was 9.0 in both Tris - HCl and glycine/NaOH buffer. The apparent Km was 0.47 mM and the apparent V 15.3 mumol/h/g wet wt of calf kidney cortex. A stimulation by div... | 10,974 | [
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... |
Studies on aspartase. III. Alteration of enzymatic properties upon trypsin-mediated activation. | Highly purified aspartase (L-aspartate ammonia-lyase, EC 4.3.1.1) from Escherichia coli, already of full activity, is further activated 3.3-fold by limited treatment with trypsin. The activation requires a few minutes to attain maximum level, and hereafter the activity gradually decreases to complete inactivation. Prio... | 10,995 | [
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0.01444603,
... |
Heterogeneity of histidine transport in the Ehrlich cell. | We have reexamined the heterogeneity shown by histidine in its uptake by the Ehrlich ascites tumor cell, in the face of a contradiction of our earlier interpretation. We again find the fraction of histidine uptake at neutral pH inhibitable by the model substrate for System A, 2-(methylamino)-isobutyric acid, to be full... | 11,000 | [
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0.3873051,
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[Effect of cocaine on the tyrosine hydroxylase of rat hypothalamus]. | The influence of cocaine on tyrosine hydroxilase of rat brain hypothalamus was investigated in vivo (0.5 mg/kg) and in vitro (10(--6)--10(--5)M). Cocaine was used as a substance with a known adrenergic type of action. It was shown that under standard conditions cocaine in vitro increased the enzyme activity and decreas... | 11,011 | [
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-... |
Differences in the altered energy metabolism of hemorrhagic shock and hypoxemia. | The effect of hemorrhagic shock, hypoxemia, and anoxia on the levels of adenine and pyridine nucleotides of liver and kidney was assessed. ATP levels in liver and kidney of animals in shock or animals subjected to 7 min of anoxia decreased by 85 and 73%, respectively. Under hypoxic conditions (arterial PO2 AT 18 MMHg),... | 11,040 | [
-0.06016487,
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0.166201,
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-0.009... |
Microdose mammography. | Tens of thousands of mammograms are performed daily in the United States. Accumulated radiation biologic data suggest that approximately 90-rad is the level of radition to the breast above which the incidence of cancer may be increase. A microdose system of roentgenography is described that provides better images at on... | 11,043 | [
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0.2564758,
0.112743,
... |
Group desensitization of dissimilar anxieties. | Group desensitization is an effective, efficient anxiety-reduction therapy that, nonetheless, is not applicable in most mental health settings. This paper outlines several procedural modifications that make possible the desensitization of diverse anxieties within a single group and thus make group desensitization a mor... | 11,056 | [
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Effect of ascorbic acid on arylsulfatase A and B activities in human chondrocyte cultures. | Cultured normal human articular cartilage chondrocytes exhibited decreasing levels of arylsulfatase A and B activities when grown in the presence of increasing levels of ascorbic acid (0 to 90 mug/ml) in the media. That this was not a general effect on all lysosomal enzymes was supported by the increase in acid phospha... | 11,078 | [
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Ferredoxin from a red alga, Porphyra umbilicalis. | A plant-algal type ferredoxin was isolated from the red alga, Porphyra umbilicalis. In its oxidised form the ferredoxin had absorption maxima at 277, (281), 323, 420 and 462 nm. Two atoms each of non-haem iron and labile sulphur were present per molecule protein. The midpoint potential of the protein was -400 mV and it... | 11,097 | [
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... |
Mechanisms by which hapten conjugates of pneumococcal polysaccharide interfere with the challenge of anti-hapten memory cells. | Incubation of trinitrophenylated hemocyanin (TNP-KLH)-primed spleen cells with microgram amounts of 2,4-dinitrophenyl (DNP) or 2,4,6-trinitrophenyl (TNP) conjugates of pneumococcal polysaccharide type 3 (SIII) for as little as 5 min at 4 degrees C results in a specific "block" of the 19 S and 7 S adoptive memory respon... | 11,101 | [
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... |
Suprression of local graft-versus-host reactions by mouse fetal and newborn spleen cells. | Fetal splenic but not thymic lymphocytes significantly reduce the ability of parenteral adult spleen cells to elicit local graft-versus-host reactions in F1 recipients. This suppressive activity wanes early after birth. There is no requirement for histo compatibility between reacting and suppressor cells. | 11,102 | [
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Antiarrhythmic action of a new beta-adrenergic blocking agent, 6-(2-hydroxy-3-isopropylaminopropyloxy)-benzothiazole succinate (KF-577), compared with that of propranolol. | The antiarrhythmic activity of a new beta-adrenergic blocking agent, 6-(2-hydroxy-3-isopropylaminopropyloxy)-benzothiazole succinate (KF-577), was compared with that of propranolol. KF-577 antagonized ouabain-induced arrhythmias in normal and bilaterally vagotomized guinea pigs; its antagonistic activity was equal to t... | 11,105 | [
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Relationship between the prevention of rat gastric erosions and the inhibition of acid secretion by prostaglandins. | The formation of gastric mucosal erosions induced by indomethacin in the rat was inhibited in a time- and dose-dependent manner by antisecretory prostaglandins, the methyl analogues of PGE2 being 400 times as active as the parent prostaglandin. PGA2, a methyl analogue of PGF2alpha and the H2-receptor antagonist metiami... | 11,107 | [
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Centrally induced reduction in sympathetic tone-a postsynaptic alpha-adrenoceptor-stimulating action of imidazolines. | Naphazoline or oxymetazoline (both 30 mug/kg) were injected into the cisterna magna of anaesthetized cats and reduced blood pressure, heart rate and the electrical discharge rate of small fibre bundles of the preganglionic sympathetic splanchnic nerve. Cats were depleted of endogenous noradrenaline by pretreatment with... | 11,108 | [
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Lower esophageal sphincter response to oral administration of cimetidine in normal subjects. | Anithistamines that specifically block the gastric and secretory action of histamine have recently been developed. One of these H2-receptor blockers, metiamide, has been found to increase lower esophageal sphincter (LES) pressure in the opossum. Because of reported agranulocytosis with metiamide, another H2-receptor bl... | 11,144 | [
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[Characteristics of two new mutant forms of erythrocyte glucose-6-phosphate dehydrogenase: "Kirovograd" G6PD and "Zhitomir" G6PD]. | The paper comprises the description of properties of three mutant forms of glucoso-6-phosphate dehydrogenase characterized according the WHO program. Preparations of the enzymes were isolated from erythrocytes of patients with G6PD deficiency from three unrelated to one another Ashkenasi families coming from the Ukrain... | 11,150 | [
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Extrinsic signals for monitoring the association reaction of proteins as introduced by fluorescent and non-fluorescent labels. | Two known dansyl labels (I, II) and 5-[2-(iodoacetamido)ethylamino]-1-naphthalene-sulfonic acid (III) and three new azo-dyes (IV - VI) were covalently attached to alpha-chymotrypsin and to basic pancreatic trypsin inhibitor by four different reactive groups. In order to protect the contact region of the proteins the co... | 11,168 | [
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The distribution of hepatitis B surface antigen in Africa and the tropics: report of a population study in Nigeria. | This preliminary study was designed to examine the distribution of hepatitis B surface antigen (HBsAg) in two contrasting groups in an urban area situated in the tropical forest belt. The sample from the traditional area represents a population of low socio-economic status, living in the central slum areas of the city,... | 11,191 | [
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Rapid microspectrofluorometric studies in EL2 cells following intracellular accumulation of dibenzocarbazoles. | Microspectrofluorometric observations were carried out in EL2 ascites cancer cells and dibenzo(a,e)fluoranthene (diB(a,e)F)-grown EL2 cells, following treatment (5 min) with three dibenzocarbazoles (1,2,7,8; 1,2,5,6 and 3,4,5,6). After microinjection of glucose-6-P leading to reduction of NAD(P), a sequence of differen... | 11,198 | [
-0.009596271,
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0.02026584,
0.1877552,
0.463834,
0.1514075,
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... |
pH-dependent binding of immunoglobulins to intestinal cells of the neonatal rat. | Rat and rabbit IgG immunoglobulins conjugated to horseradiah peroxidase as a histochemical marker bind at 0 degrees C to the luminal surface of absorptive cells in isolated segments of jejunum from 10-12-day old rats. Binding is observed at pH 6.0, near the normal luminal pH of the duodenum and jejunum at this age, but... | 11,223 | [
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... |
Interaction of erythrocytes with human serum proteins. I. Analysis of the effect of pH and ionic strength of the medium. | The effect of ionic parameters of the medium (pH and ionic strength) on the processes of interaction of tannin-treated erythrocytes and the protein fractions of human serum (macroglobulins, microbulins and albumin) was studied in factorial experiments. Complex effect of these parametres on the processes under investiga... | 11,260 | [
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The coordinate roles of branchial nerve activity and potassium in the stimulation of ciliary activity in Mytilus edulis: observations with phenoxybenzamine, bromolysergic acid and fluorescence histochemistry. | Potassium concentrations in excess of 30 mM increase the rate of beating of lateral cilia on the gill of Mytilus edulis. Cilioexcitation produced by low frequency (5 beats/s) electrical stimulation was potentiated with potassium but blocked with bromolysergic acid (a serotonergic inhibitor). Cilioinhibition produced by... | 11,265 | [
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An unusual bilateral pathological fracture. | An unusual case of a bilateral pathological fracture of the mandible has been presented. The fracture of the right side of the mandible was through an area of bacteroides osteomyelitis and the fracture of the left side of the mandible was through a large cementifying fibroma, which had replaced the left body of the man... | 11,280 | [
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The determination of phenothiazine drugs in pharmaceutical preparations by a difference spectrophotometric method. | A method is described for the rapid determination of phenothiazine drugs in a wide variety of pharmaceutical preparations. The drugs are determined by a difference spectrophotometric technique based upon the absorbance of the sulphoxide derivative of the drug relative to the absorbance of a solution of the underivatize... | 11,285 | [
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A comparison of the effects of morphine and pethidine upon body temperature and the reversal of reserpine's effects upon body temperature in the mouse. | The effects of morphine and pethidine upon body temperature and upon the reversal of reserpine hypothermia in the mouse were investigated. Both morphine and pethidine produced a dose-dependent fall in body temperature, that of morphine being totally antagonized by nalorphine and partially by naloxone, while that of pet... | 11,291 | [
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0.0744... |
Enhancement of ethonol-induced withdrawal convulsions by blockade of 5-hydroxytryptamine receptors. | Male Swiss-Webster mice were made physically dependent on ethanol using the ethanol vapour inhalation technique. Animals pretreated with methysergide, a known 5-hydroxytryptamine receptor blocking agent, had significantly greater alcohol-induced withdrawal convulsions than saline pretreated controls. These findings sug... | 11,292 | [
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Effects of animal maturity on smooth muscle and blood pressure responses to prostaglandins E2 and F2alpha. | The effects of prostaglandins E2 (PGE2) and F2alpha (PGF2-alpha) on muscle strips from mature and immature rats and guinea-pigs and on rat blood pressure were investigated in the presence of atropine. The colon and stomach strips from immature rats were equally responsive to PGE 2 and PGF2alpha where mature colons were... | 11,308 | [
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Changes in crystallinity and solubility on comminution of digoxin and observations on spironolactone and oestradiol. | Using infrared spectroscopy, X-ray diffractometry, differential thermal analysis, scanning electron microscopy, solubility and dissolution rate measurements, it was demonstrated that the comminution of digoxin results in the appearance of an amorphous phase. The examination of spironolactone and 17 beta-oestradiol by i... | 11,314 | [
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Heat treatment of laser-welded gold alloys. | (1) Three alloys, G-3, SMG-2, and Ceramco-0, showed no ductility in the aswelded condition. (2) The Ney G-3 as-welded samples had no ductility, but heat treating greatly increased their yield stress. (3) The simulated ceramic firing cycle created a small amount of ductility in SMG-2, but the lowering of the yield stre... | 11,343 | [
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Pharmacological activity of nitroxide analogues of dichloroisoproterenol and propranolol. | Spin-labeled analogues of dichloroisoproterenol and propranolol were synthesized. It was found that the KD's of both probes for the beta-adrenergic receptors of frog erythrocytes were about 30-fold higher than the KD's previously reported for the parent antagonists. Thus the introduction of a bulky nitroxide moiety in ... | 11,346 | [
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Benzodiazepines and withdrawal psychosis. Report of three cases. | Three cases of acute psychotic illness following sudden withdrawal from high daily doses of benzodiazepines were associated with agitation and confusion. Disorientation was prominent in two of the patients. None of the patients had had previous psychotic episodes. The condition of all patients was reversed dramatically... | 11,358 | [
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Effect of glucose and sucrose on the survival in batch culture of Streptococcus mutans C67-1 and a non-cariogenic mutant C67-25. Morphological studies. | This study comprised an ultrastructural examination of a cariogenic strain of Streptococcus mutans, C67-1, and a non-cariogenic mutant of that strain, C67-25. The aim of the work was to define more clearly the relationship between S. mutans and dental caries and, more specifically, to elicit ultrastructural evidence fo... | 11,393 | [
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[The problem of dissecting aneurysm of the aorta and its benign course]. | On the basis of a personal case, the clinical, diagnostic and therapeutic problems of variants of dissecting aneurysm of the aorta with benign course are discussed. The usefulness of cardio-aortic angioscintigraphy in the interests of early diagnosis of aneurysm and aortography by catheterism for specifying its locatio... | 11,426 | [
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[Preparative isolation of terrilytin components and study of their enzymatic properties]. | By ion-exchange chromatography the composition of the fibrinolytic enzyme from Aspergillus terricola-terrilytine-was studied. The preparation contained five components that differed in their substrate specificity. Three of the components and proteolytic and fibrinolytic activities. The isolated fractions were examined ... | 11,462 | [
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[Autogenic training within the therapeutic scope of schizophrenic patients]. | The author calls the reader's attention to the rather strange fact that autogenic training, in spite of worldwide recognition and extensive uses of the method in various disciplines of medicine and spheres of live, has not so far been finding wide application in the medical specialty dealing with mental disorders. Afte... | 11,518 | [
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Effects of drugs on the uptake of acetylcholine by human term placenta fragments. | An active concentrative component of the ACh accumulation in fragments of human term placenta followed kinetics predicted by the Michaelis-Menten equation (Km greater than 15 mM). This process was competitively inhibited by choline or hemicholinium-3, suggesting the possibility that a common carrier existed. Morphine r... | 11,531 | [
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Relationship of plasma motilin response to lower esophageal sphincter pressure in man. | The effect of intraduodenal instillation of 0.1 N hydrochloric acid or 0.9% saline (control) on lower esophageal sphincter pressure (LESP) and plasma motilin concentrations was studied in five normal volunteers. After acid, LESP and plasma motilin rose concomitantly exceeding basal by about 80% (p less than 0.025) and ... | 11,547 | [
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... |
Fetal thymus transplantations in severe combined immunodeficiency. | Two brothers with severe combined immunodeficiency were treated with repeated transplantations of fetal thymus tissue. The first patient was not treated until he was critically ill, and the intramuscular transplants had no effect. He died at 11 months of age of overwhelming pneumonia. At postmortem examination a transp... | 11,548 | [
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Cytotoxicity in graft-versus-host reaction. II. Lysis of target cells of parental genotyppe by F1 hybrid macrophages. | Graft-versus-host (GVH) reactions were induced in adult F1 hybrid mice with the i.p. injection of parental strain spleen cells. Peritoneal exudate and spleen cells of the F1 hybrids taken 8 days after the induction of GVH reaction had a nonspecific in vitro cytotoxic effect which was measured by using 51Cr-labeled targ... | 11,578 | [
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... |
Long survival and immunologic reconstitution following transplantation with syngeneic or allogeneic fetal liver and neonatal spleen cells. | (1)Spleen cells from newborn syngeneic and allogeneic mice that lack fully differentiated T lymphocytes can be used as a hematopoietic source to reconstitute both hematopoietic and lymphoid systems of lethally irradiated mice without producing a GVHR. (2) Fetal liver cells from syngeneic and allogeneic mice that lack p... | 11,582 | [
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0.06873163,... |
Enzyme histochemical study on fat-storing cells (so-called Ito's cell) of liver. | Inorder to gain a foothold in clarifying the functional significance of fatstoring cells, an enzyme histochemical study on these cells was carried out. Fat-storing cells showed no alkaline phosphatase, acid phosphatase or esterase activity but demonstrated a marked gamma-glutamyl transpeptidase activity suggesting the ... | 11,635 | [
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Some physicochemical properties of human leucocyte migration inhibitory factor (LIF). | Leucocyte migration inhibitory factor (LIF) obtained from human lymphocytes stimulated with concanavalin A was consistently and irreversibly blocked by the serine-esterase inhibitor phenyl-methyl sulphonylfuoride (PMSF). This effect was not due to fluoride ions, hydrolysis products of PMSF or to impurities. PMSF pulse ... | 11,637 | [
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[Distribution and ecology of Ixodes trianguliceps (Birula, 1895) (Acarina, Ixodoidea) in France, particularly in the South-East]. | Ixodes trianguliceps, parasite of insectivores and rodent mammals seems to be distributed throughout France, except in the mediterranean low altitude areas. This tick which does not manifest any parasitic specificty, has meanwhile preferred hosts (Clethrionomys glareolus, especially). At low altitudes, it likes forests... | 11,660 | [
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0.4334375,
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Buoyant density of some togaviruses in sucrose density gradient and capacity of their haemagglutinin fractions to interact with antibody. | The buoyant densities of Western equine encephalomyelitis virus (an Alphavirus) and tick-borne encephalitis (TBE) virus (a Flavivirus) antigens prepared by different methods were studied. Sucrose density centrifugation revealed a heterogeneity in the density of the virions. The sedimentation pattern and height of peaks... | 11,662 | [
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Some immunological mechanisms of the influenza virus antitumour effect. | Vaccine strains of influenza A virus inhibited the growth of ascitic tumour cells and outbred rats or inbred mice. The infected tumour bearers had an enhanced immune response to viral and specific tumour antigens. These phenomena are apparently due to the formation of complexes of both antigens on cell membranes and in... | 11,666 | [
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Stable erythrocyte diagnostic preparation for passive haemagglutination test with herpes simplex virus antigen. | A method for the preparation of stable suspensions of erythrocytes sensitized with herpes simplex virus (HSV) antigen and for their use in the passive haemagglutination test (PHAT) was developed. Formolized sheep erythrocytes were treated with tannin and sensitized with HSV antigen prepared from infected chick embryo c... | 11,670 | [
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-0.2647201,
0.6721827,
-0.4583234,
0.3619091,
0.09456245,
-0.1541893,
-0.1146415,
... |
Present state of alpha and beta adrenergic drugs. II. The adrenergic blocking agents. | There are selective blocking agents (antagonists) for alpha receptors and beta receptors. These blocking agents prevent the response to injected agonists and neurogenically released norepinephrine. The principal cardiovascular response to alpha blockade is postural hypotension with reflexly induced cardiac stimulation.... | 11,680 | [
-0.04883566,
-0.2280761,
-0.4952004,
-0.5611506,
0.2174722,
-0.3410676,
-0.2343812,
-0.1915927,
-0.03842496,
-0.04023793,
0.09955325,
0.3280456,
0.1231307,
0.0462106,
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-0.2793399,
-0.4799686,
0.0656535,
-0.07194186,
0.2468734,
-0.02759073,
0.05241139,
-0.028718... |
Pharmacology and therapeutic use of antihistamines. | The classes of antihistaminic agents, their pharmacology and therapeutic uses, adverse effects, drug interactions, toxic overdoses and abuse are reviewed. It is concluded that antihistamines are valuable drugs for treating a number of conditions and diseases (e.g. allergic rhinitis, motion sickness and parkinsonism), b... | 11,685 | [
-0.4976582,
-0.09766331,
-0.2803232,
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0.07038374,
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0.07581884,
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0.08167479,
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0.06963929,
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0.2871862,
-0.1076195,
-0.02171387,
0.101... |
Effect of virus infection on the inflammatory response. Depression of macrophage accumulation in influenza-infected mice. | To better define the mechanisms by which viruses depress immune function, the effect of influenza infection on the ability of macrophages to accumulate at sites of inflammation was determined. Mice were inoculated with virus, and their inflammatory response measured in vivo by counting the number of leukocytes which ac... | 11,695 | [
-0.1477948,
-0.2681889,
-0.3731461,
-0.1940334,
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0.009431965,
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0.01702061,
0.1880108,
0.01774151,
0.2908879,
-0.04598146,
-0.1896267,
0.04756... |
Formation of slow-reacting substance by guinea pig immunoglobulins. | The capacity of guinea pig antibodies to mediate the antigen-induced release of slow-reacting substance (SRS) in the rat peritoneal cavity is restricted to IgG2 and, to a lesser extent, to IgG1 populations of immunoglobulin. IgM and homocytotropic antibody of the reaginic type lacked this activity. The process was part... | 11,696 | [
0.1646097,
0.02312367,
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0.1086835,
0.3272102,
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0.2548873,
0.0668034,
0.1296359,
-0.1045095,
-... |
Fluctuation in activity of the molecular forms of cellular DNA polymerase during infection by SV40. | Infection of BSC-1 cells by SV40 brings about an increase of 7--11-fold in DNA polymerase activity, found in the nuclei and cytoplasm, respectively. The overall ratio between activites of DNA polymerase beta (3.1S) and DNA polymerase alpha (5.5S) remains fairly constant throughout infection. However,there is a large in... | 11,762 | [
-0.1380636,
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0.3214578,
0.4356486,
0.4221554,
0.04420966,
0.03416193,
... |
Thiol-protein disulphide oxidoreductases. Assay of microsomal membrane-bound glutathione-insulin transhydrogenase and comparison with protein disulphide-isomerase. | 1. Inhibition of endogenous microsomal NADPH oxidase by CO enables membrane-bound glutathione-insulin transhydrogenase (EC 1.8.4.2) to be assayed conveniently by a linked assay involving NADPH and glutathione reductase (EC 1.6.4.2). 2. The specific activity of the enzyme in rat liver microsomal preparations is of the o... | 11,783 | [
-0.0790021,
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-0.09457765,
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0.2357789,
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0.07797263,
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0.2011553,
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0.3157482,
0.01904055,
0... |
The action of psychotropic drugs on DOPA induced behavioural responses in mice. | The "DOPA potentiation" test in mice was investigated for its usefulness in the detection of compounds with antidepressant properties. It was found that the anti-depressant drugs imipramine, amitriptyline, 5-methylamino-acetyl-6-methyl-5,6-dihydro-phenanthridine-HCl (Org OI77) and 1,2,3,4,10,14b-hexahydro-2-methyl-dibe... | 11,809 | [
-0.2755963,
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0.5252995,
0.003645207,
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0.2287603,
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0.2818525,
-0.5351935,
0.4758349,
0.3251698,
0.5046613,
0.2038823,
-0.2353884,
-0.204137,
-0... |
Fluorine-containing analogues of intermediates in the Shikimate pathway. | The phosphoenolpyruvate analogue (Z)-phosphoenol-3-fluoropyruvate is a substrate for phenylalanine-inhibitable 3-deoxy-D-arabino-heptulosonic acid-7-phosphate synthase from Escherichia coli. In the presence of excess erythrose 4-phosphate, apparent KM values of 65 and 38 muM were observed for phosphoenol-3-fluoropyruva... | 11,811 | [
-0.3318183,
0.05576436,
-0.4058441,
0.07728854,
0.09389555,
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0.3542742,
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0.1579931,
0.3201747,
0.1973547,
-0.2279284,
0... |
Studies on the ferrochelatase activity of isolated rat liver mitochondria with special reference to the effect of oxidizable substrates and oxygen concentration. | The mitochondrial ferrochelatase activity has been studied in coupled rat liver mitochondria using deuteroporphyrin IX (incorporated into liposomes of lecithin) and Fe(III) or Co(II) as the substrates. 1. It was found that respiring mitochondria catalyze the insertion of Fe(II) and Co(II) into deuteroporphyrin. When Fe... | 11,817 | [
-0.3381113,
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-0.4630699,
0.3574097,
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0.03326676,
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-0.1422478,
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0.3006627,
0.07941537,
0.1978929,
0.0452618,
... |
Fluorescence properties of 2' (or 3')-O-(2,4,6-trinitrophenyl) adenosine 5'-triphosphate and its use in the study of binding to heavy meromyosin ATPase. | 2' (or 3')-O-(2,4,6-Trinitrophenyl) adenosine 5'-triphosphate (N3ph-ATP), which contains a Meisenheimer complex moiety, is one of the class of compounds which do not fluoresce in water but fluoresce both in low polarity solvents and when bound to the protein molecule. Fluorescence intensity of N3ph-ATP in the range of ... | 11,824 | [
-0.3466944,
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0.2985481,
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0.05959501,
0.7569299,
-0.1493752,
-0.1154646,
... |
Excretion and metabolism of nikethamide in the horse. | It is well known that nikethamide (N,N-diethylnicotinamide, CoramineR) is metabolized very rapidly to nicotinamide. Hence, there is difficulty in proving that nikethamide has been used as a doping substance because nicotinamide is a normal physiological metabolite in the organism as well as a vitamin preparation. Howev... | 11,864 | [
-0.4096351,
0.3104432,
-0.3491941,
0.01232462,
0.5476884,
-0.181383,
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0.04891741,
0.1688965,
0.1442001,
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0.08987257,
0.04422342,
0.2363803,
0.2311651,
0.3220661,
-0.01676286,
-0.1... |
Studies on the multiple forms of gamma-glutamyltransferase. | In sera of 53 patients with highly raised gamma-glutamyltransferase (gamma-GT) (EC 2.3.2.2) activity, the gamma-GT was separated by column chromatography on Sephadex DEAE A-50 into two fractions. In 35 sera only one gamma-GT fraction was found at a conductivity of 2.0--2.5 mS and in 18 sera two gamma-GT fractions were ... | 11,908 | [
0.007243906,
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-0.1604952,
-0.1467255,
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0.3402628,
0.2561693,
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-0.433281,
-0.1482646,
-0.005037019,
0.2983648,
0.2192194,
0.10478,
-0.2869809,
... |
Lorazepam in the treatment of neurosis. | An open study was carried out in 40 ambulatory neurotic patients with classical symptoms of anxiety to assess which of their symptoms responded most readily and favourably to treatment with lorazepam. Doses ranged from 2 mg to 15 mg daily and were adjusted to individual patient needs. The study period lasted 4 weeks an... | 11,961 | [
-0.04533662,
-0.116998,
-0.01752915,
-0.3058979,
0.07802302,
-0.2966728,
-0.4368066,
-0.4274765,
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0.1457062,
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0.02691578,
0.08572558,
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-0.6468139,
0.2621027,
-0.1788034,
0.005041143,
0.2455213,
0.1194417,
-0.0255145... |
Immediate hypersensitivity to tuberculin. In vivo and in vitro studies. | Immediate responses of hypersensitivity to skin testing with purified derivative of tuberculin (PPD) were observed in 2.3 percent of 3,248 patients seen in an allergy clinic, and the relationship to delayed responses was questioned. Immediate cutaneous reactions to testing with PPD appeared in all age groups and occurr... | 11,970 | [
0.03438186,
-0.2523948,
-0.3345782,
0.0515522,
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0.1315782,
0.104149,
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0.1939642,
0.07923542,
0.1616567,
0.15828,
0.1825347,
0.1809716,
-0.... |
Plasma testosterone in prepubertal cryptorchid boys under long-term HCG therapy. | Plasma testosterone concentrations were determined before and after 6 weeks of human chorionic gonadotropin treatment in 36 prepubertal boys with bilateral or unilateral cryptorchidism. Mean +/- SD basal and post-treatment values (ng/100 ml) in the bilateral group were: treatment successful (n = 14): 32 +/- 19 and 302 ... | 12,073 | [
-0.1140997,
0.1631159,
-0.3644046,
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0.2443054,
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0.1742831,
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0.01176613,
0.3163846,
0.362534,
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0.1772339,
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-0.01027428,
0.3305149,
0.3406215,
-0.09626734,
... |
Completed pregnancy following vascularized heterotopic autotransplantation of the Fallopian tube in the ewe. | Transplantation of the Fallopian tube is a technically feasible operation. Previous authors have reported pregnancies following turbo-ovarian transplants, but there appears to be no record of gestation following transplantation of the isolated oviduct. This communication illustrates the method that we have used to perf... | 12,117 | [
-0.08218689,
-0.03572135,
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0.106883,
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0.3114156,
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0.1414834,
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-0.366951,
-0.04783089,
0.3903699,
-0.048123... |
Blastoid transformation of lymphocytes in response to spermatozoa. | Microlymphocyte transformation tests were done on 33 female rabbits immunized with different components of rabbit ejaculate. In rabbits injected with total ejaculate or washed spermatozoa a specific stimulation of lymphocytes could be demonstrated by exposure to washed spermatozoa. It is shown that it is necessary to n... | 12,120 | [
0.05521656,
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0.03712974,
0.1867541,
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0.03241668,
0.652405,
0.2777123,
0.2519823,
-0... |
Reduced red cell membrane potential and acidification of the plasma in response to contrast materials. Time course of the alteration in plasma pH. | Radiographic contrast materials added to blood reduce the red cell membrane potential by balancing the internal impenetrable anions, hemoglobin and organic phosphates. In so doing, a redistribution of protons occurs such that plasma is acidified. The time course of acidification of plasma is measured in seconds, with a... | 12,127 | [
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0.05719003,
0.1146505,
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0.1049216,
0.08955938,
0.1002659,
0.2537341,
0.02222077,
0.1560786,
-... |
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