title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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The "Moonies": a psychological study of conversion and membership in a contemporary religious sect. | The authors undertook this study to enhance psychiatric understanding of contemporary charismatic religious sects. After a pilot study, a representative sample of members of the Unification Church (N = 237) completed a 216-item structured questionnaire. Respondents were below the mean for an age- and sex-matched group ... | 760,544 | [
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Towards an understanding of chronic pain mechanisms: the use of psychologic tests and a refined differential spinal block. | Forty patients with chronic pain below the waist level were evaluated in a multidisciplinary pain clinic using a refined differential spinal block (DSB) technique. The refinements consisted of verbal instructions to prevent biasing the patients, coupled with a thorough evaluation of verbal and physiologic responses to ... | 760,599 | [
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Effect of two organophosphorus insecticides on the phosphate-dissolving soil bacteria. | Dimethoate and malathion added to soil at 10 and 100 microgram/g caused an initial stimulation of CO2 production. Total counts of bacterial propagules were increased. All insecticide applications increased bacteria producing phospholipases from week 1 until week 4 after the application; bacteria then returned to the o... | 760,634 | [
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Selective antibacterial action of 2-mercaptoethanol on propionibacteria in skin cultures. | 2-Mercaptoethanol applied to the surface of agar medium had a selective antibacterial effect on Propionibacterium acnes and Propionibacterium granulosum without interfering with the growth of Peptococcus saccharolyticus or staphylococci in anaerobic cultures of skin or in pure cultures. In aerobic broth culture, 2-merc... | 760,636 | [
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Pleural fluid lysozyme in human disease. | Lysozyme content was measured in the plasma and pleural fluid of 110 patients with pleural effusions of various causes. The concentration of pleural fluid lysozyme was significantly higher (P less than .001) in patients with tuberculous pleurisy than in those with primary pulmonary carcinoma, metastatic carcinoma of th... | 760,686 | [
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Crossing the border into borderline personality and borderline schizophrenia. The development of criteria. | Although there is a large psychiatric literature on various "borderline" conditions, there has been no agreement as to the definition of the concept. A review of the literature reviewed two major uses of the term: Borderline Schizophrenia and Borderline Personality. Two item sets were developed to provide diagnostic cr... | 760,694 | [
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Suicide and alcoholism. Interpersonal loss confirmed as a predictor. | We earlier reported that nearly one third of a consecutive series of 31 alcoholics who committed suicide had experienced loss of a close interpersonal relationship within six weeks or less of their death. In a replication study of 50 additional unselected alcoholic suicides, we found that 26% had experienced such loss ... | 760,697 | [
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Trigeminal neurotization of paralyzed facial musculature. Modification of the Lexer-Rosenthal surgical procedure. | We introduce a modification of the Lexer-Rosenthal surgical technique for reinnervation of the facial muscles by trigeminal neurolization in patients with facial paralysis. Four patients with such paralysis were seen in the Cranial Nerve Research Clinic, Oakland, Calif. Three of the four patients had their paralysis su... | 760,700 | [
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Clinical implications in calibration requirements in bone conduction standardisation. | Although international agreement has long been reached on a standard threshold for air conduction audiometry, no similar standard exists for bone conduction autiometry. It is argued that the techniques applied to the determination of the air conduction thresholds are not applicable to those for bone conduction which sh... | 760,723 | [
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Hearing-aid-processed signals: a new approach. | A new protocol for obtaining and utilizing hearing-aid-processed signals in hearing aid research or hearing aid selection is described. Data are presented which illustrate the extent to which this procedure may be expected to result in a signal spectrum at the subject's eardrum which is the same as the spectrum the sub... | 760,725 | [
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The effect of ageing on the hepatic clearance of propranolol. | 1. Plasma propranolol concentrations were measured in healthy old and young subjects following single oral doses of 40 mg, single i.v. infusions of 0.15 mg kg-1 and after nine 40 mg oral doses given four times daily. 2. In each of the three studies, the elderly had higher plasma propranolol concentrations than the youn... | 760,742 | [
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Metabolism of sulphadiazine in malnutrition. | 1. The kinetics of sulphadiazine were studied in well-nourished and under-nourished subjects. 2. The metabolic clearance rate of a single dose of sulphadiazine given either orally or intravenously was faster in under-nourished subjects. 3. The plasma protein binding of the drug was found to be reduced in under-nourishe... | 760,744 | [
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Haemodynamic and electrocardiographic effects of intravenous disopyramide (rythmodan) following acute myocardial infarction. | 1 The haemodynamic and electrocardiographic effects of intravenous disopyramide were studied in fifteen patients with acute myocardial infarction. 2 Five minutes after drug injection a rise in heart rate, aortic mean and diastolic pressures and systemic vascular resistence was noted which persisted for at least 30 min.... | 760,751 | [
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Amniocentesis with and without ultrasound guidance. | The increasing use of amniocentesis requires that the technique be made as safe as possible. The results of 284 amniocenteses done under ultrasound control are presented and compared with the results of 140 amniocenteses performed without ultrasound control. The use of ultrasound guidance increased the success rate fro... | 760,758 | [
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Cell adhesion and spreading factor: chemical modification studies. | The purified fetal calf serum factor that promotes cell adhesion and spreading of baby hamster kidney cells on tissue culture substrata has been subjected to a variety of chemical modifications and then tested for activity. These studies have shown that modification of the carbohydrate portions of the factor by glycosi... | 760,793 | [
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The effect of ethanol on glycerolipid biosynthesis by primary monolayer cultures of adult rat hepatocytes. | This study evaluates the effects of ethanol exposure on glycerolipid production and release by hepatocyte monolayers. Glycerolipid formation from [1,3-14C]glycerol was increased in monolayers exposed to ethanol (1--50 mM) for 6 h. Monolayers exposed to 1 mM ethanol for 24 h also exhibited a rise in glycerolipid formati... | 760,795 | [
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Alteration of the lipase activities of muscle, adipose tissue and liver by rapeseed oil feeding of rats. | Feeding rapeseed oil, rich in erucic acid, for 4 days results in a significant increase of the lipoprotein lipase activities of heart and adipose tissue. The lipase activity of liver, which in earlier studies has been shown to be releasable by heparin perfusion, also increases by the dietary regimen. The increased lipo... | 760,798 | [
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Local interactions as a structure determinant for protein molecules: II. | Van der Waals interactions between sidechains are indicated to be important in determining the native state of the proteins of known structure by the following observations: 1. the average radial distribution of polarity increases continuously from the center of the molecule to its periphery. 2. nonpolar sidechains ten... | 760,806 | [
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I-cell disease: intracellular desialylation of lysosomal enzymes using an influenza virus vector. | It has been proposed that I-cell disease results from a primary deficiency of acid neuraminidase activity. Infection by influenza virus of fibroblasts from a patient with I-cell disease resulted in the production of abundant intracellular alpha2-3 neuraminidase activity. Despite electrophoretic evidence of desialylatio... | 760,815 | [
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Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver. | Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver have been investigated. After perfusing the lung to remove contaminating blood, this organ was found to have an apparent concentration of glutathione (2mM) which is approx. 20% of that found in the liver. Both or... | 760,819 | [
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Extracellular matrix metabolism by chondrocytes. 5. The proteoglycans and glycosaminoglycans synthesized by chondrocytes in high density cultures. | Proteoglycans were extracted from the extracellular matrix of cultures of embryonic chick chondrocytes grown at high density and were purified by CsC1 density gradient centrifugation. The chemical, physical and hyaluronate binding properties of the proteoglycans were similar to those observed in proteoglycans from othe... | 760,824 | [
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Additional comments on the use of Wiener filtering for the estimation of evoked potentials. | The problem of average potentials filtration in the case of periodic stimulation is discussed in the paper. Some considerations proving the correctness of Wiener filtering processes suggested by Doyle are presented here. The basic assumption of the proof is an approximation of the noise power density by means of a step... | 760,834 | [
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[Hematopoietic organs in mice following a single administration of hydrocortisone]. | Kinetics of the number and direction of CFU differentiating in mice after a single infusion of hydrocortisone in a dose of 5 mg per mouse was studied using the method of an exogenous cloning of the stem cells in the spleen and the bone marrow of the irradiated recipients. Against the background of the long-term involut... | 760,836 | [
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[Changes in hemodynamic and endocrine-metabolic parameters in the early post-resuscitation period]. | Changes in the system hemodynamics, renal and hind limb blood flow, as well as some endocrine-metabolic parameters were studied in 24 dogs which survived 17-minute circulatory arrest. As revealed, relative compensation and normalization of several functions and metabolic parameters in the course of 1 hour after reanima... | 760,840 | [
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[Cytotoxic effect of BCG-activated macrophages on tumor target cells in vitro]. | The macrophage-activating effect of fluid and lyophilized BCG vaccines and killed BCG was studied. Activation of murine peritoneal macrophages was determined by their cytotoxic action in vitro on the syngeneic tumour 51Cr-labeled target cells. Murine macrophages obtained 2 to 3 weeks after a single injection of the flu... | 760,842 | [
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[Transplacental blastomogenic effect of p-hydroxyphenyl lactic acid]. | Transplacental administration of tyrosine metabolite p-hydroxyphenyl lactic acid having blastomogenic activity induced development of malignant and benign neoplasms (leukemias and lymphosarcomas, adenomas and pulmonary carcinoma, hepatomas, papillomas, and cancer of the urinary bladder and other tumours) in progeny of ... | 760,843 | [
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A centrally mediated prolonged hypotension produced by oxotremorine or pilocarpine. | 1 Oxotremorine, methyloxotremorine, pilocarpine or arecoline were given intravenously to anaesthetized cats, dogs or rats, and intraperitoneally to conscious normotensive and spontaneously hypertensive rats, pretreated with doses of methylatropine that completely blocked peripheral muscarinic receptors, to ascertain th... | 760,887 | [
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Effects of noradrenaline and carbachol on temperature regulation of rats. | 1 Noradrenaline (0.2 to 20 micrograms) and carbachol (0.1 to 1 microgram) injected into the preoptic/anterior hypothalamic area, evoked dose-dependent falls in core temperature at all sites tested, followed in most experiments by delayed increases that were not dose-related. Muscarine (0.1 to 10 microgram) produced eff... | 760,890 | [
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0.1963452,
0.06808155,
0.2133133,
0.1788265,
... |
Detection of deep venous thrombosis by scanning of 99mtechnetium-labelled red-cell venous pool. | A comparative study of 32 patients with suspected deep venous thrombosis was carried out using blood-pool radionuclide scanning and conventional x-ray phlebography. Results of the two methods showed close agreement, the sensitivity (positive correlation) of the scan being 100% and its specificity 89%. We conclude that ... | 761,002 | [
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5-HT concentration in cat's brain. | Endogenous concentrations of TRP, 5-HT and 5-HIAA were determined in the different cortical and subcortical areas of adult cat's brain, using ion-exchange chromatography and spectrofluorimetric methods. Tryptophan is homogeneously distributed in all structures of the brain. 5-HT is mainly accumulated in the brain stem... | 761,067 | [
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Further observations on transganglionic degeneration in trigeminal primary sensory neurons. | Transganglionic degeneration has been studied with the Fink-Heimer method in the trigeminal sensory nuclei of adult cats and rats following peripheral nerve transections. Degeneration was observed ipsilaterally as well as contralaterally in all cats, surviving 11-30 days after transection of the infraorbital nerve. In ... | 761,074 | [
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An intraspinal sympathetic preganglionic pathway: physiologic evidence in the cat. | Electrical stimulation of the zona intermedia of the lower thoracic/upper lumbar cat spinal cord resulted in increases of heart rate (HR), blood pressure (BP) and cardiac contractility (dp/dt). Sites of maximal cardiovascular response (SMCR) were localized histologically to the intermediolateral nucleus (ILN). The inot... | 761,078 | [
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Effect of halothane on the pulmonary vascular response to hypoxia in dogs. | The pulmonary vascular response to alveolar hypoxia with and without halothane exposure was measured in dogs. Hypoxia increased pulmonary artery pressure (Ppa) and pulmonary vascular resistance (PVR) so that in each case inverse linear relationships were found with arterial oxygen saturation. These responses were highl... | 761,116 | [
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Bone and joint tuberculosis: a continuing problem. | Although tuberculous disease of bones and joints is becoming uncommon, it still occurs and may cause devastating sequelae. It is frequently not diagnosed prior to the onset of permanent damage to the joints or spine; the most important reason for this delay may be the fact that it is not considered in the differential ... | 761,142 | [
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0.1141198,
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On the prognostic importance of white depressed areas in the primary lesion of superficial spreading melanoma. | The lesions of 163 patients with superficial spreading melanoma (SSM) were examined for the presence of white, depressed areas; and lesions with and without these areas of "regression" were compared. There was no statistically significant correlation with the histological level of invasion (Clark-Mihm), sex or age of t... | 761,159 | [
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0.04940332,
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Fecal bile acids in two Japanese populations with different colon cancer risks. | Some workers have associated fecal bile acids with colon cancer frequency. They suggest that the risk for colon cancer increases with a rise in the level of total and degraded fecal bile acids. The Japanese in Hawaii, who are at high risk for this cancer, had higher concentrations of deoxycholic acid (a degraded bile a... | 761,204 | [
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... |
Nuclear ultrastructure of epithelial cell lines derived from human carcinomas and nonmalignant tissues. | The nuclear ultrastructure of sixteen human epithelial cell lines has been characterized in detail by transmission electron microscopy. The cell lines were derived from normal tissues, nonmalignant tissues of cancerous organs, primary carcinomas, and metastatic carcinomas. Every cell section on a grid containing a clea... | 761,205 | [
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... |
Inhibitory effect of growth hormone on Gross passage A virus-induced thymus leukemia in C3Hf mice. | Administration of ovine growth hormone to young C3Hf mice inhibited Gross passage A virus-induced leukemogenesis as manifested by a delayed onset and a lower incidence of thymus leukemia. These results can be interpreted that growth hormone inhibited thymus-dependent leukemogenesis perhaps through thymotrophic influenc... | 761,214 | [
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Dihydrofolate reductase in primary brain tumors, cell cultures of central nervous system origin, and normal brain during fetal and neonatal growth. | Dihydrofolate reductase (DHFR) was measured during the development in rats of brain tumors induced following inoculation with avian sarcoma virus. Increasing activity of this enzyme in brain was correlated with the course of primary brain tumor growth. The specific activities of DHFR in primary human brain tumor tissue... | 761,221 | [
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0.02609... |
Presence and cell growth-related variations of glycogen in human colorectal adenocarcinoma cell lines in culture. | The presence and kinetics of intracellular glycogen levels were studied, in relationship to cell growth, in asynchronous and in synchronized cultures of four human colorectal adenocarcinoma cell lines (HT-29, HRT-18, SW-480, and Caco-2). The results show that a specific pattern of glycogen accumulation occurs during th... | 761,227 | [
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0.1605681,
0.5058772,
0.4363296,
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Radioimmunoassay for pantothenic acid in blood and other tissues. | We describe a radioimmunoassay for pantothenic acid in biological tissues. D-Pantothenic acid was conjugated with bovine serum albumin by use of a bromoacetyl derivative of pantothenic acid, and antibody to this antigen was raised by injecting it into the foot pads of rabbits. For the radioimmunoassay, a 100-fold dilut... | 761,345 | [
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Performance of the Du Pont aca ammonia method. | We evaluated the performance of the Du Pont aca ammonia procedure with regard to (a) linearity, (b) precision, (c) interferences, and (d) effect of anticoagulants. Linearity extends to 2,000 mumol/L. The SD of the method was essentially constant (2 to 3 mumol/L) and independent of the NH3 concentration. Hemoglobin, bil... | 761,361 | [
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Determination of amniotic fluid phospholipids by thin-layer chromatography, with use of a hydrogen flame ionization detector. | We describe a new specific method for measuring lecithin, sphingomyelin, and phosphatidylglycerol in amniotic fluid by thin-layer chromatography, with use of a hydrogen flame ionization detector. After extraction and acetone precipitation to isolate surface-active lecithin, the phospholipids are separated on a thin rod... | 761,375 | [
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Dual-isotope separation technique for radioassay. Precision of calculated results affected by degree of separation. | The dual-isotope separation technique for radioassay is reviewed. An expression is derived describing the effect of counting errors on the precision of the calculated bound count rate in the dual-isotope technique. This mathematic model is tested in experiments using sodium iothalamate (I-125) as a marker in the Phadeb... | 761,388 | [
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0.... |
Enhancement by L-dopa of the renal action of aldosterone in the rat. | 1. The administration of aldosterone to adrenalectomized rats produces an increase in K+ and decrease in Na+ excretion in the urine. The relationship of the post-aldosterone to the pre-aldosterone urinary sodium and potassium excretion is termed the renal response to aldosterone. 2. The administration of L-dopa enhance... | 761,430 | [
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0.1012003,
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... |
Simultaneous modeling of pharmacokinetics and pharmacodynamics: application to d-tubocurarine. | We propose a model of drug pharmacodynamic response that when integrated with a pharmacokinetic model allows characterization of the temporal aspects of pharmacodynamics as well as the time-independent sensitivity component. The total model can accommodate extremes of effect. It allows fitting of simultaneous plasma co... | 761,446 | [
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... |
A computer program for life table regression analysis with time dependent covariates. | This paper presents a computer program for analyzing time-dependent covariables in survival studies by the life table regression model described by Holford [3]. Basically, life table regression incorporates the elements of regression and the life table into a single model. Regression parameters are estimated by the met... | 761,455 | [
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... |
Hydromediastinum after aberrant central venous catheter placement. | After central venous catheter placement via the right subclavian route, a hydromediastinum was produced. Aberrant placement of the catheter was undiscovered for 13-1/2 hours despite clinical and radiographic signs. Careful interview of the patient and analysis of postcatheterization chest radiographs are imperative in ... | 761,472 | [
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Multiple determination of cardiac output using a two-bottle technique. | A technique is described to perform multiple determinations of cardiac output; two 150 ml bottles of 5% dextrose in water, stored in identical conditions, are immersed in an ice slush, contained in a styrofoam cooler. Comparison of cardiac output determinations obtained with this technique and with multiple syringes in... | 761,474 | [
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0.06927767... |
Chromosomal imbalance in ovulated oocytes from Syrian hamsters (Mesocricetus auratus) and Chinese hamsters (Cricetulus griseus). | Chromosomes were studied in ovulated oocytes from Syrian hamsters (Mesocricetus auratus) and Chinese hamster (Cricetulus griseus) to assess the degree of chromosomal imbalance after first meiotic division of oogenesis. Only one hyperploid oocyte among 307 studied was detected in the former, and none in oocytes from the... | 761,487 | [
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[Comparison of bicycle ergometry and step-ladder exercise (author's transl)]. | Repeat exercises (three hours apart) on a bicycle ergometer and a vertical step-ladder were performed in a randomised series on 79 subjects: 13 doctors, 44 patients and 22 sportsmen. Duration of exercise was on average 250% longer in the three groups on the step-ladder than the bicycle. Correspondingly, exercise-pulse ... | 761,518 | [
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0.02395714,
0.115187... |
Genetic relation of life span to metabolic rate for inbred mouse strains and their hybrids. | Average life spans were estimated for the male progeny from 21 of the 25 possible matings of 5 inbred mouse strains. Oxygen consumption was measured in an open system over a 48-hour interval. Resting metabolism, Mre, and average metabolism, Mav, were determined at 6-8 months of age, and at 24-34 months. Body weight, W,... | 761,651 | [
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Bronchial mucosal cells. | The eight epithelial cell types and their features are described--the basal, Kultschitzsky, intermediate, brush, ciliated, serous, Clara, and mucous cell. In the irritated airway the separate secretory cell types are able to change, through transitional cell types, from the Clara and the serous to the mucous cell. Each... | 761,653 | [
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... |
Spermatic grauloma: an often painful lesion. | Spermatic granulomas are specialized abscesses which frequently occur at the site of vasectomy. Although some are often silent, others can be agonizingly painful. A series of 154 granulomas is presented. Of these, 83 were symptomatic and 63 required surgery for relief of pain. | 761,679 | [
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Connective fibers involved in the dermoepidermal anchorage. An electron microscopical study. | The human dermoepidermal anchoring fibrils, the oxytalan fibers and the elaunin fibers have been related with dermoepidermal adherence. In the present work their ultrastructure and origin are studied. The similarity between the segment longspacing tropocollagen molecular aggregates and the anchoring fibrils band patter... | 761,689 | [
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... |
Glucagon-induced small intestinal hypotonia demonstrating bleeding lymphoma. | While a patient was being evaluated for melena, a glucagon-induced hypotonic examination of the small intestine demonstrated a small ulcerated mass in the jejunum. The tubeless hypotonic examination was performed after multiple gastrointestinal series, small intestinal series, barium enemas, and visceral arteriography-... | 761,746 | [
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0.4780534,
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0.224119,
0... |
[The forensic value of the length and weight of newborns, the placental weight and the correlation between placental and newborn weight in the evaluation of paternity (author's transl)]. | The length of the infant, the weight of the infant, the weight of the placenta, and the correlation between the weight of the placenta and the weight of the infant are coarse parameters for the estimation of the maturity of an infant. We plotted these parameters of 20,000 deliveries in relationship to the stated length... | 761,753 | [
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[Secondary amenorrhoea in a case adrenocortical tumour (author's transl)]. | The paper reports on a rare case of a secondary amenorrhea caused by a tumour of the adrenal cortex. The exact preoperative diagnosis, the therapy and the further postoperative control are discussed. | 761,759 | [
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Serum alkaline phosphatase phenotypes and secretor status in several Jewish populations in Israel. | The frequency of serum alkaline phospatase phenotypes and secretor trait is determined for Israeli Jews originating from three distinct geographical regions: Eastern and Central Europe (group I), North Africa (group II) and the Middle East (group III). The frequency of the Pp 2 serum alkaline phosphatase phenotype in e... | 761,918 | [
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... |
Effects on in vitro tumor growth of macrophages isolated from human ascitic ovarian tumors. | Macrophages were isolated from 22 human ascitic ovarian epithelial tumors and their growth-inhibitory capacity was tested using as targets the following in vitro tumor cell lines: murine TLX9 lymphoma and FS6 sarcoma; human myeloid K562 leukemia and human E cell line derived from an ovarian carcinoma. Macrophage prepar... | 761,940 | [
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0.5236948,
0.2695979,
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Metabolic fate of aromatic hydrocarbons in aquatic organisms: analysis of metabolites by thin-layer chromatography and high-pressure liquid chromatography. | Aquatic organisms convert aromatic hydrocarbons into a variety of conjugated and nonconjugated derivatives. Analytical techniques based on thin-layer chromatography (TLC) and high-pressure liquid chromatography (HPLC) were employed to separate, identify and quantitate individual metabolites from fish exposed to radiola... | 761,967 | [
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Contrast sensitivity of the human neonate measured by the visual evoked potential. | Visual evoked potentials (VEPs) were recorded from a total of 97 1- to 10-day-old infants, with phase-reversing sinusoidal grating stimuli. The grating contrast or spatial frequency for which 50% of infants gave a statistically significant VEP was taken as a measure of threshold. This procedure yielded an estimate of n... | 761,974 | [
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-... |
Psychodiagnosis and psychoanalytic psychotherapy. | Patients with conditions in the intermediate range of severity often show adequate capacity to test reality but poor ego integration. To many, a modified psychoanalytic method is often applied. These patients are not easily classified within the standard nomenclature. The term "borderline" has been applied, in an illde... | 761,988 | [
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0.2560665,
-0.09118138,
... |
Thienamycin, a new beta-lactam antibiotic. I. Discovery, taxonomy, isolation and physical properties. | A new beta-lactam antibiotic, named thienamycin, was discovered in culture broths of Streptomyces MA4297. The producing organism, subsequently determined to be a hitherto unrecognized species, is designated Streptomyces cattleya (NRRL 8057). The antibiotic was isolated by adsorption on Dowex 50, passage through Dowex 1... | 761,989 | [
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0.223108,
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Piperacillin (T-1220), a new semisynthetic penicillin. II. In vitro antimicrobial activity and synergy comparison with carbenicillin and gentamicin. | Piperacillin, a new semisynthetic penicillin, was found to have potent antimicrobial activity against nearly all (405) tested bacterial species. Piperacillin was consistently 4 approximately 16-fold more active than carbenicillin against the Enterobacteriaceae, 16 approximately 32-fold against Pseudomonas aeruginosa an... | 761,991 | [
0.02867501,
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0.0297481,
0.2521736... |
Biosynthesis and cellular distribution of the two superoxide dismutases of Dactylium dendroides. | The synthesis and subcellular localization of the two superoxide dismutases of Dactylium dendroides were studied in relation to changes in copper and manganese availability. Cultures grew normally at all medium copper concentrations used (10 nM to 1 mM). In the presence of high (10 muM) copper, manganese was poorly abs... | 762,015 | [
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... |
Haloperidol-induced comatose state with hyperthermia and rigidity in adolescence: two case reports with a literature review. | Two adolescents who developed severe extrapyramidal and hypothalamic reactions due to haloperidol therapy are describe. This is a rarely reported result of utilizing this medication in children and youth, and caution is urged in its use. Prolonged reactions have occurred. | 762,029 | [
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Benzodiazepines in the treatment of aggressive patients. | A double-blind, controlled clinical trial of chlordiazepoxide, oxazepam and placebo was conducted in 65 outpatients with past histories of temper outbursts, assaultive behaviour and impulsiveness associated with anxiety, irritability and hostility. Of those tests showing statistically significant results, there was a t... | 762,032 | [
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0.02620069,
... |
Proteins exposed on the outer surface of the plasma membranes of AH-66 hepatoma ascites cells. | The cell surface proteins of AH-66 hepatoma ascites cells were examined both by fluorescent labeling with cycloheptaamylose-fluorescamine complex and by radioiodination with lactoperoxidase. The labeled proteins were analyzed by measuring the distribution of fluorescence or radioactivity in polyacrylamide gels after el... | 762,041 | [
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Amino acid sequences of the alpha and beta chains of adult hemoglobin of the European hedgehog, Erinaceus europaeus. | Globin prepared from hemoglobin of the European hedgehog (Erinaceus europaeus) was separated into alpha and beta polypeptide chains by chromatography on a CM 52 column. The S-aminoethylated alpha and beta chains were each digested with trypsin and the resulting peptides were isolated. The sequences of all the tryptic p... | 762,046 | [
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Ribulose-1,5-biphosphate carboxylase. Evidence in support of the existence of distinct CO2 activator and CO2 substrate sites. | Ribulose-1,5-biphosphate carboxylase forms a complex with Mn2+ and CO2 that exhibits a considerably enhanced water proton relaxation rate. This effect is diminished upon interaction of the complex with the substrate, ribulose biphosphate, or with the competitive inhibitor, ribitol 1,5-biphosphate (Ki=0.55 mM). Included... | 762,058 | [
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0.... |
Biological effects of cesalin, an anti-tumor protein, on cultured mammalian cells. | The effects of the protein cesalin were studied to determine the site of its toxic action in KB cells for which the ID50 is 0.9 pg/ml. Several effects have been noted: (i) respiration in KB cells was reduced by greater than 50% within 1 h after cesalin addition, which could not be explained on the basis of mitochondria... | 762,073 | [
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The amino acid sequence of dihydrofolate reductase from the mouse lymphoma L1210. | The determination of the amino acid sequence of the dihydrofolate reductase (EC 1.5.1.3) from cells of the mouse lymphoma L1210 is described. The protein was cleaved by cyanogen bromide to produce the six fragments CB1 (residues 1 to 14), CB2 (residues 15 to 52), CB3 (residues 53 to 111), CB4 (residues 115 to 125), CB5... | 762,074 | [
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... |
Isolation and characterization of single chain bovine factor V. | A procedure for the isolation of bovine Factor V has been developed. The Factor V is isolated from bovine plasma by a series of steps including barium citrate adsorption, polyethylene glycol precipitation, QAE-cellulose adsorption, hydrophobic chromatography on octyl Sepharose, ammonium sulfate fractionation, preparati... | 762,076 | [
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0.294251,
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0.02173172,
-0.06256782... |
Structural studies on human spectrin. Comparison of subunits and fragmentation of native spectrin. | Native spectrin has trypsin-susceptible sites spaced at a constant molecular weight interval. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis of spectrin treated with trypsin at low salt concentrations shows a ladder of fragments spaced at approximately 8,000-dalton intervals, from the intact Band 1 (240,000 ... | 762,104 | [
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0.1787442,
0.2180775,
0.3816763,
-0.0211... |
The subunit structure of thrombin-activated factor V. Isolation of activated factor V, separation of subunits, and reconstitution of biological activity. | Activated Factor V (Va) was prepared by treating a high molecular weight form of Factor V with thrombin. The activated Factor V was isolated by ion exchange chromatography and was composed of two polypeptide chains (Mr = 115,000 and 73,000). These chains were separated by ion exchange chromatography in the presence of ... | 762,106 | [
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0.4205719,
0.08204278,
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0... |
The structure and stability of human plasma cold-insoluble globulin. | The molecular properties of cold-insoluble globulin have been investigated by velocity centrifugation, circular dichroism, and fluorescence at neutral and alkaline pH. The stability of the protein to thermal and guanidine hydrochloride has been evaluated under both conditions. The close parallelism between the properti... | 762,148 | [
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0.4963,
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... |
Malate dehydrogenase, inhibition of pig heart supernatant enzyme by iodoacetamide. | Pig heart supernatant malate dehydrogenase is alkylated by 250 mM iodoacetamide at 37 degrees C in pH 7.5 Tris/acetate buffer which is 0.05 M with respect to acetate to form enzyme with 1,3-dicarboxamidomethyl histidine, 3-carboxamidomethyl histidine, 1-carboxamidomethyl histidine, carboxamidomethyl cysteine, and carbo... | 762,157 | [
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0.007001094,
0.499607,
0.01090374,
0.194617,
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0.115... |
Identification of ATP citrate lyase as a phosphoprotein. | ATP citrate lyase has been purified from rat liver by a new procedure which results in high yields of an intact and stable enzyme. The pure lyase (specific activity approximately equal to 10 at 25 degrees C) exhibits a single protein band upon sodium dodecyl sulfate (SDS)-gel electrophoresis (Mr = 110,000). This proced... | 762,167 | [
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0.1994721,
0.1293262,
-0.007229037,
0.2520164,
-0.0941775... |
An electron microscopic study of pyruvate carboxylase. | Pyruvate carboxylases, purified to homogeneity from sheep and chicken liver, have been examined in the electron microscope and found to have a splayed tetrahedral structure which, in some views, appears similar to that described for this enzyme isolated from yeast. The square-planar tetrameric image previously ascribed... | 762,170 | [
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0.14147,
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0.05... |
A re-examination of the electron microscopic appearance of pyruvate carboxylase from chicken liver. | Electron microscopic studies of chicken liver pyruvate carboxylase conducted under a variety of conditions show that this enzyme has an overall rhombic appearance and is comprised of four nonspherical subunits. The square planar tetramers originally identified by Valentine et al. (Valentine, R.C., Wrigley, N.G., Scrutt... | 762,171 | [
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0.1309385,
0.04941655,
0.1392918,
-0.2765964,
-0.20... |
Determination of propranolol and six metabolites in human urine by high-pressure liquid chromatography. | A method for the determination of propranolol and six of its metabolites, as well as their glucuronide and/or aryl sulfate conjugates in human urine is described. Propranolol and its basic and neutral metabolites are extracted into ether at pH 9.8, evaporated to dryness, reconstituted, separated on a reversed-phase, hi... | 762,208 | [
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0.1179222,
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-... |
Gas-liquid chromatography of isobutyl ester, N(O)-heptafluorobutyrate derivatives of amino acids on a glass capillary column for quantitative separation in clinical biology. | A gas chromatographic method adapted to routine analysis has been developed for quantitative separation on glass capillary columns for free proteic and other known amino acids normally or abnormally found in physiological fluids. The procedure involves ion-exchange chromatography and isobutyl ester, N(O)-heptafluorobut... | 762,216 | [
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0.2391302,
-0.01118336,... |
A specific and sensitive method for the determination of the anticoagulant phenprocoumon in plasma. | A specific thin-layer chromatographic assay for phenprocoumon has been developed with a sensitivity of 5 ng/ml of plasma, using only 0.2 ml. This sensitivity is more than 20 times higher than that of the published methods. The drug is extracted from acidified plasma, an aliquot of the extract is applied to a silica-gel... | 762,222 | [
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0.5570872,
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0.2281963,
0.01849963,
... |
Lymphocyte adherence in multiple sclerosis: effect of aspirin. | Peripheral blood lymphocytes from multiple sclerosis (MS) patients form substantially greater numbers of rosettes with measles virus-infected human epithelial cells than do lymphocytes from healthy controls or from patients with other diseases. We have previously shown that prostaglandin E(1)-treated normal lymphocytes... | 762,244 | [
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The handling of immunoreactive vasopressin by the isolated perfused rat kidney. | Using the isolated rat kidney perfused with an artificial medium containing glucose as the sole fuel, we studied the renal handling of immunoreactive arginine vasopressin (AVP) and determined the effect of various factors on the ability of the kidney to remove AVP. In control kidneys perfused with AVP at concentrations... | 762,248 | [
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Analysis of parathyroid hormone and its fragments in rat tissues: chemical identification and microscopical localization. | After intravenous injection of [(125)I]-iodo-parathyroid hormone in the rat, uptake of the hormone was greatest in the liver and kidneys. Uptake was rapid, reaching a maximal concentration by 4 and 8 min, respectively. Extracts, prepared from both these organs at intervals soon after the injection of intact hormone, sh... | 762,250 | [
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Electrophysiologic properties of coffee in man. | There is no information on the effects of coffee on the human conduction system. His bundle electrograms were obtained in 12 patients before and 20 minutes after the ingestion of coffee containing 150 mg caffeine. Antegrade and retrograde refractory periods were obtained with the extrastimulus method. The effective and... | 762,254 | [
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... |
A Golgi study of the early postnatal development of the visual cortex of the hooded rat. | Although neuroanatomical plasticity has been demonstrated in the rat visual cortex, no systematic data on the dendritic development of the area are available. In the present study, the visual cortex of hooded rats at 1, 3, 5, 7, 10 and 15 postnatal days of age (P1-P15) was impregnated with the rapid Golgi method. The c... | 762,257 | [
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0.03117847... |
An electron microscope study of the early postnatal development of the visual cortex of the hooded rat. | Synaptic plasticity in response to environmental events has been clearly demonstrated in the visual cortex of the rat, but no detailed data concerning the course of early synaptogenesis in this area are available. In this study, synaptogenesis in the visual cortex of hooded rats at 1, 3, 5, 7 and 10 postnatal days of a... | 762,258 | [
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0.14672... |
The generation of neurons involved in an early reflex pathway of embryonic mouse spinal cord. | The generation of lateral motor neurons (LMNs), interneurons and dorsal root ganglion (DRG) neurons of the cervical mouse spinal cord has been investigated by [3H]thymidine autoradiographic techniques. This investigation has two main objectives: (a) to determine on which embryonic days these three neuronal populations ... | 762,268 | [
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0.09594589,
... |
Proprioceptive reflex connections of head musculature and the mesencephalic trigeminal nucleus in the carp. | The location of the sensory cells concerned with the proprioception of respiratory and extraocular musculature in the carp was studied by retrograde transport of horseradish peroxidase. Sensory cell labeling after intramuscular HRP injection was exclusively found in the trigeminal-facial-anterior lateral line ganglion ... | 762,276 | [
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0.1753663,
... |
Does immunotherapy have any value in the treatment of malignant melanomas? | To date, immunotherapy has not proven to be curative of malignant melanomas. Some immunologic procedures have produced regressions of some recurrences and perhaps have prolonged life by eliminating some dispersed malignant cells that would have gone to metastasis, but have not affected established, disseminated metasta... | 762,297 | [
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... |
The relationship of family structure and interaction to nutrition. | The relationship of nutritional adequacy to family structure and interaction is reviewed in light of previous research. Family structure is described by demographic data and measures of organization and status discrepancy of family members. Measures of family interaction include parent-child interactions, shared activi... | 762,338 | [
-0.1356536,
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0.3161705,
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0.2383543,
0.05950657,
0.06620716,
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Nutritional status of white college students in Virginia. | The nutritional status of the fifty men, fifty-three women, and forty-seven women taking oral contraceptives--all white--between the ages of seventeen and twenty-two years--as reflected by height-weight measurements, hemoglobin-hematocrit values, and dietary records, was similar or slightly better than reported by othe... | 762,340 | [
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0.1325245,
0.3570468,
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0.... |
Vietnam, 1978: crisis in food, nutrition, and health. | Evidence of shortages of food, medical equipment, and supplies and indications of malnutrition were observed by an American Study Mission to Vietnam in the summer of 1978. Recommendations of humanitarian aid were made by the study team and presented as promoting peace and stability in Southeast Asia. | 762,356 | [
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A social policy directed toward the health and welfare of the aged in the Soviet Union. | Dealt with in detail are the factors which have determined the characteristics and peculiarities of medical and social care for the aged in the USSR. The forms of geriatric care, personnel training and delivery of social and domestic services to the aged are also presented. Facts are given about the state policy direct... | 762,366 | [
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... |
Dihydroergotoxine: 6-mg versus 3-mg dosage in the treatment of senile dementia. Preliminary report. | In 14 patients with senile dementia, a study was made of two dosage levels (3 mg or 6 mg daily) of dihydroergotoxine mesylate (DEM, Hydergine). Only a nonstatistically significant trend was found for superiority of the higher dosage. However, one patient showed remarkable clinical improvement during the 6-mg period; th... | 762,369 | [
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Measuring contrast sensitivity with gratings: A new simple technique for the early diagnosis of retinal and neurological disease. | The measurement of contrast sensitivity using gratings is a new clinical procedure which yields information about the functioning of the visual system. Previously, this type of information has not been readily obtainable in the clinical environment. This article includes the basic concepts of measuring contrast sensiti... | 762,375 | [
-0.145143,
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The electroretinogram: concepts and clinical applications. | This paper describes the clinical applications of the electroretinogram (ERG). Its purpose is to familiarize the practitioner with the capabilities, and limitations, of the ERG. This discussion includes ERG theory, test procedures, and interpretation of results. | 762,378 | [
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0.03944228,
0.2040154,
... |
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