title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Elongation factor T from Bacillus stearothermophilus and Escherichia coli. Purification and some properties of EF-Tu and EF-Ts from Bacillus stearothermophilus. | Homogeneous preparations of elongation factors EF-Tu and EF-Ts from Bacillus stearothermophilus have been obtained with specific activities of 20000 +/- 2000 and 500000 +/- 50000 units/mg, respectively. By dodecylsulphate-polyacrylamide gel electrophoresis the molecular weight of EF-Tu was found to be 49000 +/- 2000 an... | 767,105 | [
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The Stein-Leventhal syndrome: a neuropituitary disorder. | Hypothalamic and pituitary gonadotropin function and responsiveness in four patients with well-documented Stein-Leventhal syndrome were studied. All patients were of reproductive age and had had menstrual disorders since menarche. Estrogen production was assessed by measuring the circulating levels of immunoreactive es... | 767,160 | [
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The conservative restoration of class IV and VI defects. | Success in conservatively restoring Class IV and VI defects depends upon the method of retention and the restorative material chosen to best fulfill the clinical need. This need is determined by the size of the defect and its location in the arch relative to the functional load, age, vanity, and general dental apprecia... | 767,175 | [
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Early behavioral differences: gender or circumcision? | In human studies, the possible long-term effects on behavior of early physical insult or pharmacological agents have received little attention. We present both circumstantial and direct evidence that circumcision of male infants leads to behavioral changes. In some American studies using circumcised infants, reported ... | 767,183 | [
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Inhibition of insulin rlease by scorpion toxin in rat pancreatic islets. | Toxin purified from venom of the scorpion Leiurus quinquestriatus was used to release the norepinephrine from adrenergic nerve terminals in isolated pancreatic islets perifused in vitro. Addition of toxin (10 mug./ml) to the perifusion medium caused a sixfold increase in release of norepinephrine in the presence or abs... | 767,185 | [
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Insulin and the glucose-glucagon feedback mechanism in the duck. | The relationship between insulin and the glucose-glucagon feedback mechanism was studied by testing the effectiveness of various routes, doses and timing of insulin administration prior to and during a glucose tolerance test in Peking ducks made transiently diabetic by subtotal pancreatectomy. Insulin injections or inf... | 767,188 | [
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Search for a biochemical basis of diabetic microangiopathy. | Diabetic microangiopathy, particularly as seen in the renal glomerulus, is characterized by morphological and biochemical alterations of the capillary basement membrane. Observations from a number of disciplines have indicated that the microvascular disease is not a separately inherited entity but a true consequence or... | 767,187 | [
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[Base pair substitutions induced by Escherichia coli K-12 mutator gene prv]. | Using the trpA system of Yanofsky, it is shown that the mutator gene prv of Escherichia coli K-12 induces transitions in both directions (A:T in equilibrium G:C), and not A:T leads to leads to C:G and C:G leads to A:T transversions. The prv1 mutation was found to be recessive in prv+/prv1 merodiploid. | 767,212 | [
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Outcome studies of therapeutic community and halfway house treatment for addicts. | This paper reviews the outcomes of follow-up studies of addicts in therapeutic communities. The aim is to assess the research problems in such studies and the range of recovery rates found. It was found that controlled studies are few in number and available only for correctional institutions, not for Daytop, Synanon, ... | 767,260 | [
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Biochemical properties of cultivated Mycobacterium lepraemurium. | 1. Dehydrogenase activity of whole cell of cultivated M. lepraemurium is accelerated with sodium laurate, but not with the other substrates. 2. Dehydrogenase activity of cell free extract of cultivated M. lepraemurium is accelerated with citrate or malate. 3. There is no acceleration of oxygen consumption corresponding... | 767,264 | [
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Transplant nephrectomy and simultaneous second graft retransplantation. | Tranplant nephrectomy and retransplantation has become an established modality in treating patients with rejected kidney allografts. Experience with 29 patients who underwent simultaneous transplant nephrectomy and retransplantation is presented. This procedure did not involve a considerably greater risk than a primary... | 767,295 | [
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Excision repair of ultraviolet-irradiated deoxyribonucleic acid in plasmolyzed cells of Escherichia coli. | A system of cells made permeable by treatment with high concentrations of surcrose (plasmolysis) has been exploited to study the excision repair of ultraviolet-irradiated deoxyribonucleic acid in Escherichia coli. It is demonstrated that adenosine 5'-triphosphate is required for incision breaks to be made in the bacter... | 767,327 | [
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Regulation of lysine transport by feedback inhibition in Saccharomyces cerevisiae. | A steady-state level of about 240 nmol/mg (dry wt) occurs during lysine transport in Saccharomyces cerevisiae. No subsequent efflux of the accumulated amino acid was detected. Two transport systems mediate lysine transport, a high-affinity, lysine-specific system and an arginine-lysine system for which lysine exhibits ... | 767,329 | [
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Evaluation of the hemolysis-in-gel test for the screening of rubella immunity and the demonstration of recent infection. | The hemolysis-in-gel method for detection of antibodies to rubella virus gave results which correlated well with results of hemagglutination inhibition and neutralization tests. With a diffusion time of 24 or 48 h, a linear correlation was obtained between the logarithm of antibody concentration and the diameter of the... | 767,364 | [
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Bone morphology and bone loss in periodontal disease. | A clinical study of the distribution of different types of bone defects in chronic periodontitis was carried out on 30 patients. An analysis of 176 defects suggests that their distribution reflects the original morphology of the alveolar bone. The role of function as a determinant of that morphology is examined. While ... | 767,365 | [
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Experimental contribution to the pathogenesis of spina bifida. | Reopening of the central canal in 3-day-old chick embryos results in the development of a typical myeloschisis within 5 min. Focal continuity between the ectoderm and neural tissue at the site of experimentally induced spina bifida (SB) may be achieved in 2 hr and increases in consecutive hours. In 24 hr a secondary ne... | 768,430 | [
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Discriminating adolescent male delinquents through the use of kinetic family drawings. | Studied the discriminatory potential of the Kinetic Family Drawing technique (KFD). The drawings of 20 male adolescent delinquents were compared to a group of 20 normal male adolescents in order to discover whether any hypothesized differences existed. Significant chi square differences were found on only three of the ... | 768,443 | [
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Effect of continuous infusion of gonadotrophin-releasing hormone in ewes at different times of the year. | Gn-RH (3 mug/hr for 8 hr) evoked a surge of LH in ewes during the anoestrous season which was of similar peak height to that found at oestrus but of shorter duration. When Gn-RH was given on 3 consecutive days, the response was considerably reduced on the 2nd and 3rd day. Follicles grew as a result of Gn-RH infusion bu... | 768,465 | [
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The interrelation of LH-RH, ovarian steroids and the adenohypophysis. | In this presentation experimental evidence is reviewed and new information is presented concerning the question of cyclic fluctuations in pituitary responsiveness to endogenous and exogenous hypothalamic-releasing hormones as well as the direct role of steroids in modulating pituitary sensitivity. Experiments are descr... | 768,469 | [
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Antimalarials. 8. Synthesis of amino ethers as candidate antimalarials. | Based upon the antimalarial activities demonstrated by compounds I and II a series of amino ethers represented by structures III-VI was synthesized. These structures incorporated several modifications of compound II. The compounds prepared displayed no activity in either the Rane P. berghei mouse screen or the Rane P. ... | 768,473 | [
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Immunosuppression by Moloney leukemia virus: lack of correlation between virus replication and the immunosuppressive effect. | Young adult mice were infected with 10(4) plaque-forming units (PFU) or Moloney murine leukemia virus M-MuLV. Two different virus preparations were used: a) M-MuLV obtained from serial passage in mice [animal passage (AP)] and b) tissue culture (TC)-grown virus harvested after three in vitro passages of the AP M-MuLV i... | 768,506 | [
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Identification and preliminary characterization of a mutant defective in the bacteriophage T4-induced unfolding of the Escherichia coli nucleoid. | The nucleoids of Escherichia coli S/6/5 cells are rapidly unfolded at about 3 min after infection with wild-type T4 bacteriophage or with nuclear disruption deficient, host DNA degradation-deficient multiple mutants of phage T4. Unfolding does not occur after infection with T4 phage ghosts. Experiments using chloramphe... | 768,519 | [
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[Present state in synchronization therapy of malignant tumors and acute leukemias (author's transl)]. | Chemotherapy of malignant tumors can be made more effective by synchronization of the cell cycle. Synchronization therapy consists of a synchronizing step (phase I), an interval and a cytocidal step (phase II). Some regimens till now approved in clinical treatment are presented. The results are found to be encouraging.... | 768,630 | [
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[Core and surface antigen of the Dane particle in liver tissue - relation to different forms of hepatitis B (author's transl)]. | The complete Dane particle consists of two serologically and morphologically different components: Core (HBc) and Surface (HBs). HBc is located almost exclusively in the liver cell nucleus and can be demonstrated by immunofluorescence and electron microscopy, but not by light microscopy. HBs is located exclusively in t... | 768,668 | [
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The induction of mutation in yeast by hydrogen peroxide. | The inactivation and mutation to respiratory deficiency of yeast cells by H2O2 are shown to vary progressively with the phase of cell growth, with a sharp transition occurring as the cells complete logarithmic growth. Respiratory deficient mutants isolated from the wild-type population are of two types, one of which is... | 768,759 | [
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Late psychologic effects of a serious illness in childhood. | The results of psychologic testing and parent interviews showed that children who experience catastrophic illness between 2 and 5 years of age do not necessarily have severe adjustment problems at a later date. Only 2 of the 18 children studied, who are long-term survivors of childhood cancer, have been found to have m... | 768,931 | [
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Identification of biological molecules in situ at high resolution via the fluorescence excited by a scanning electron beam. | Proteins, nucleic acids, and fluorescein-conjugated antibody are shown to be identifidable in situ via the fluorescence excited by the focused electron beam of a canning electron microscope. A molecular species is identified by its characteristic fluorescence spectrum and by a characteristic alteration of the spectrum ... | 768,980 | [
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The free musculocutaneous flap. | We report the transfer of a free musculocutaneous compound flap, including the gracilis muscle, in one stage by microvascular surgery. The advantages of this free flap are discussed. | 769,005 | [
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Thumb reconstruction in the severely burned hand. | The standard techniques have generally been adequate for thumb reconstruction in the severely burned hand. The basic principles of preservation of length, prevention of malposition and contracture by appropriate splinting, early motion, and early skin coverage are all applicable. The nature of the tissue changes wrough... | 769,006 | [
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Free skin flap from the retroauricular region to the nose. | We present two new, one-stage methods for resurfacing a part of the face-- (1) the microvascular transfer of a free retroauricular flap, and (2) an island flap from the galea covered by a full-thickness skin graft from the retroauricular region. Both procedures provided the same good color match, without leaving a read... | 769,007 | [
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Tissue distribution of 14C-labeled ethylene disbromide in the guinea pig. | A study was undertaken to determine the tissue distribution of uniformly 14C-labeled ethylene dibromide in guinea pigs following intraperitoneal administration. Organs containing the greatest concentration of radioactivity per unit weight (kidneys, liver, adrenals, pancreas, and spleen) were the same organs in which pa... | 769,120 | [
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[Digestive complications and kidney transplantations]. | A survey of 54 patients who had received one or two renal homografts revealed that 15 presented 18 types of serious digestive complications. A relation between immunosuppressive treatment and subsequent appearance of a complication is frequently encountered. Gastrointestinal bleeding constitutes a real danger for the t... | 769,153 | [
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[Direct bonding in orthodontics]. | Composite materials have been used to attach orthodontic brackets on the conditioned enamel surface. A method of direct bonding with Enamelite of metal brackets with a mechanical retention on the basis is described. Clinical experience with the adhesive technique, its range of indication and possible failures are discu... | 769,154 | [
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Renal transplantation between HL-A haploidentical donor-recipient pairs: functional and morphological evaluation. | Fifty-nine recipients received renal allografts from an HL-A haploidentical family member. Immunogenicity of the incompatible haplotype was measured by skin grafts exchanged within each family when possible, and renal allograft recipients were assigned prospectively to two groups depending on the skin graft survival ti... | 769,209 | [
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Perfusion time and the survival of cadaver transplants. | Perfusion of cadaver kidneys up to 48 hours did not adversely affect the long-term renal allotransplant function and did not result in an increased rate of rejection. In fact, cadaver kidneys perfused for longer periods of time had a slightly better functional survival rate than did kidneys perfused for shorter periods... | 769,218 | [
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Perfusion-related injury in renal transplantation. | The implantation and one hour post-transplant renal biopsies from three types of allograft recipients were compared with a blind grading system: (1) 25 cadaver kidneys preserved by pulsatile perfusion, (2) seven cadaver kidneys preserved by simple hypothermia following electrolyte solution flush, (3) 18 kidneys from li... | 769,223 | [
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Nonstaphylococcal bacteria in renal cortical abcess. | Five cases of renal cortical abscess are presented, of which four yielded gram-negative pathogens. Along with a review of the recent literature, this suggests that nonstaphylococcal bacteria are a more common cause of this disease. | 769,286 | [
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[Morphology of transplanted liver. an experimental study (author's transl)]. | Experimental orthotopic livertransplantation is a very difficult procedure (Largiadér). This is due to the difficult specific anatomy of the liver, the high sensibility of the liver against anoxia and the distrubance of blood coagulation during transplantation. This investigation demonstrates that ischemia does not onl... | 769,354 | [
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[Several biological properties of the surface antigens of the agent of pseudotuberculosis]. | Capsular substance and extracellular proteins of the causative agent of pseudotuberculosis caused in the organism of guinea pigs a specific immunological reconstruction with the accumulation in the blood of antibodies in low titres, chiefly of macroglobulin type. The blood sera of these animals failed to protect the mi... | 769,431 | [
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Studies of Escherichia coli O antigen specific antibodies in human milk, maternal serum and cord blood. | Studies of Escherichia coli O antigen specific antibodies in human milk, maternal serum and cord blood. Acta Paediatr Scand, 65:216, 1976.--The quantity and class specificity of E. coli O antibodies in human milk, maternal serum and cord blood was determined by the enzyme-linked immunosorbent assay. The predominant Ig-... | 769,481 | [
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Kinetics of the reactive cell clones after immunosuppression and induction of tolerance: (1) inhibition of 19 S and 7 S plaque-forming cells in the primary and secondary immune response to sheep red blood cells by cyclophosphamide and 036.5122 (Asta). | The kinetics of the reactive cell clones after primary and secondary immunization with SRBC1) modified by cyclophosphamide and a newly synthesized cyclophosphamide analogue 036.5122 (Asta), have been studied. After primary immunization, both substances caused a severe and dose dependent depletion of 19 S PFC2). The 7 S... | 769,507 | [
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The effect of cycle length on cardiac refractory periods in the denervated human heart. | We have previously demonstrated that the transplanted human heart is functionally denervated. With the use of the extra stimulus technique during His bundle electrocardiography, refractory periods of the arterioventricular (A-V) conduction system were determined at several heart rates after pacing-induced changes in cy... | 769,517 | [
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Histological analysis of undecalcified thin sections of archeological bone. | Archeological bone often lends itself to histological analysis. Sections from bone samples approximately one thousand years old may show as much structural preservation as those only a few hundred years old; hence, it appears that the degree of preservation is not necessarily affected by time. Enough structure may be p... | 769,565 | [
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Cerebral hemodynamic crisis. Physiology, pathophysiology, and approach to therapy. | The physiology and pathophysiology of the cerebral circulation have been discussed in relation to treatment of the cerebral hemodynamic crisis. Data are presented to show how cerebral vascular resistance, the intracranial compartments, and brain metabolic demand may be manipulated to effect internal decompression and r... | 769,584 | [
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Dysrhythmias associated with oral surgery. | Seventy-eight fit adult patients undergoing minor oral surgery received one of three intravenous premedications or were unpremedicated. Cardiac rhythm was monitored during surgery. A significantly higher incidence of dysrhythmias was associated with intravenous atropine 0-3 mg/given prior to surgery. Droperidol 0-1 mg/... | 769,595 | [
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Thiopentone and suxamethonium crash induction. An assessment of the potential hazards. | A technique of 'crash induction' using thiopentone and suxamethonium with cricoid pressure was studied in 100 unselected patients at risk from vomiting or regurgitation. No episode of regurgitation occurred. There was difficulty with intubation due to poor relaxation in 7 patients and, in 61 cases, it was believed that... | 769,596 | [
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Antagonism of neuromuscular blockade. | Although acetylcholinesterase inhibitors are accepted antagonists of nondepolarizing neuromuscular blockade, many basic questions are still unanswered. What is the relationship between receptor occupancy and adequate ventilation? What are the effects of changes in acid-base balance and temperature? What are the mechani... | 769,606 | [
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Prescribing of chloramphenicol in ambulatory practice. An epidemiologic study among Tennessee Medicaid recipients. | During the 1-year period from July 1973 through June 1974, 1761 chloramphenicol prescriptions were written for 992 outpatients in the Tennessee Medicaid program. Sxi percent (250 of 3409) of participating physicians prescribed chloramphenicol; 20 physicians wrote 55% of the prescription. Both family practice and rural ... | 769,624 | [
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Leukotactic dystunction in sarcoidosis. | The leukotactic function of patients with sarcoidosis was studied. A defect was found in 19 of the 20 patients tested and was due to moderately elevated serum levels of the chemotactic factor inactivator. The chemotactic factor inactivator levels were not as high as those previously reported in patients with Hodgkin's ... | 769,631 | [
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Normal disposition of oxazepam in acute viral hepatitis and cirrhosis. | Oxazepam (Serax) is a tranquilizer-sedative of the benzodiazepine group that is predominantly metabolized to a pharmacologically inactive glucuronide and subsequently excreted by way of the kidneys. We administered this drug as a single oral dose to seven patients with acute viral hepatitis, to six with cirrhosis, and ... | 769,632 | [
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Antibiotic resistance and Hly plasmids in serotypes of Escherichia coli associated with porcine enteric disease. | A total of 359 hemolytic Escherichia coli strains, representing eight pig pathogenic serotypes and isolated from pigs with enteric disease, was tested for transferable resistance to eight antibiotics. The co-transfer of plasmids controlling hemolysin production (Hly) with antibiotic resistance plasmids (R-factors) was ... | 769,674 | [
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Elimination of resistance determinants from R-factor R1 by intercalative compounds. | Eighteen deoxyribonucleic acid (DNA)-complexing compounds, among them 15 intercalative substances, and, additionally, nalidixic acid eliminated with different frequencies four antibiotic resistance determinants from the R-factor R1, carried by Salmonella typhimurium. Eliminating concentrations did not inhibit growth of... | 769,675 | [
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Clinical and pharmacological studies of ticarcillin in gram-negative infections. | Twenty-seven patients with serious gram-negative infections were treated with ticarcillin in an average daily dosage of 237 mg/kg (range, 174 to 307 mg/kg). Ticarcillin was bactericidal for all infecting organisms in concentrations ranging from 31.2 to 125 mug/ml. Five of 8 patients (62%) with overwhelming Pseudomonas ... | 769,676 | [
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Suppressive activity of mefloquine in sporozoite-induced human malaria. | Mefloquine hydrochloride [WR 142,490; alpha-(2-piperidyl)-2,8-bis(trifluoromethyl)-4-quinolinemethanol hydrochloride] was tested for suppressive effect on sporozoite-induced malaria in nonimmune volunteers living in an area where malaria is not naturally transmitted. Single doses of 250 mg were given at weekly interval... | 769,678 | [
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Clamp for wire closure of sternum. | A modification of the Kocher clamp used for wire closure of the sternum is described. With the clamp applied securely to the individual strands, the wire can be readily twisted; the shorter length of the clamp allows the surgeon a much firmer grip on the wire and saves considerable time during closure. | 769,713 | [
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Influence of operating room surface contamination on surgical wounds: a prospective study. | The influence of operating room contamination on wound infection rates in clean, clean-contaminated, contaminated, and septid procedures was studied by a prospective randomized study of 2,020 surgical wounds. Operating room surface contamination was assessed by the RODAC bacterial plate method. Control rooms uniformly ... | 769,751 | [
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[Pathologic anatomy of experimental listeriosis]. | The authors present a survey of the Soviet and foreign literature and findings of their own experimental studies. On the basis of these data the pathologo-anatomic picture of listerosis in laboratory animals (white mice, guinea-pigs and rabbits) is given in dynamics and histogenesis of focal changes in this disease in ... | 769,757 | [
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0.2946824,
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Double blind trial of L-dopa in chronic schizophrenia. | A double blind study in 28 patients with chronic schizophrenia was carried out comparing L-dopa (up to 1250 mgm daily) with placebo (both groups continuing to receive regular neuroleptic medication) over a six week period. Assessments by the psychiatrists and psychologist using Rockland and Pollin Rating Scale showed d... | 769,772 | [
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Isolation of Yersinia (Pasteurella) pseudotuberculosis from the Palm dove (Streptopelia senegalensis). | Yersinia pseudotuberculosis was isolated from a sick Palm dove (Streptopelia senegalensis) picked up near a turkey farm in Nir-Banim, Israel. Clean birds and a guinea pig inoculated with the isolate died of the infection, or were killed in extremis. Y. pseudotuberculosis showing the same cultural characteristics as the... | 769,770 | [
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Air operations and circadian performance rhythms. | This paper reviews experimental results and pertinent data from the literature on circadian behavioural rhythms and their modifications through various factors. It relates them to the operation of aircrews "round the clock" and on transmeridian routes and discusses some possibilities of an appropriate scheduling. | 769,776 | [
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0.05709... |
[Simplification of methods for the study of beta hemolytic Streptococcus in faryngeal exudate]. | A procedure of possible epidemiological application is described. The material is taken from pharynx in infants in an attempt to control the serious problem of rheumatic fever in our environment. The investigation is carried out in two steps: in the first, the samples are inoculated in a selective medium impregnated in... | 769,798 | [
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Immunogenicity of a rat leukaemia of spontaneous origin (SAL). | The SAL rat leukaemia, which resembles acute myeloblastic leukaemia, appeared initially to be non-immunogenic since resistance to an i.p. challenge with as few as 100 cells could not be obtained using stimulation of the RES or by immunization with SAL cells exposed to x-rays, nitrogen mustard, iodoacetate or glutaralde... | 769,814 | [
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0.001453941,
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The altered fibrous form of vitreous collagen following solubilization with pepsin. | Collagen occurs in the extracellular matrix of the bovine vitreous as fibers which have a fairly uniform diameter of approximately 195 A and exhibit an indistinct axial periodicity. Following treatment with pepsin approximately three quarters of the collagen was rendered soluble and by gel electrophoresis and compariso... | 769,829 | [
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Development of bacteriophage Ha2, a phiX174 derivative, in Escherichia coli strains carrying a thermosensitive mutation in the dnaG gene. | Ha2 is a derivative of HaHb, a phiX174 mutant able to grow on several Escherichia coli K 12 strains which are insensitive to phiX174 wild type. Ha2 was isolated after nitrous acid mutagenesis and selected as being able to give large plaques in equal number at 42 degrees C as well as 30 degrees C when plated on Escheric... | 769,843 | [
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Brain concentrations of biogenic amine metabolites in acutely treated and ethanol-dependent rats. | 1 Mass fragmentography was used to measure whole brain concentrations of some of the major metabolites of tyramine, octopamine, dopamine and noradrenaline in acutely treated and in ethanol-dependent rats. 2 Treatments with ethanol, either acutely or chronically, failed to alter significantly brain concentration of p-hy... | 769,883 | [
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Causes of failure to harvest cadaver kidneys for transplantation. | Fifty-two possible donors of cadaver kidneys were referred to the Nuffield Transplantation Surgery Unit, Edinburgh, in 12 months. Only 12 (23%) yielded kidneys, while a further 12 were medically unsuitable as donors. Refusal by relatives to allow cadaver nephrectomy was the largest avoidable loss of potentially transpl... | 769,904 | [
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Results of a randomized study comparing DTIC with TIC mustard in malignant melanoma. | This prospective randomized Eastern Cooperative Oncology Group (ECOG) study (1071) was designed to compare a new and promising cytotoxic agent TIC Mustard (triazeno imidazole carboxamide mustard, NSC 82196) with DTIC (dimethyl triazeno imidazole carboxamide, NSC 45388) in the treatment of inoperable melanoma. One hundr... | 769,936 | [
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0.4184998,
0.04306188,
0.2413939,
-0.0393435... |
Role of DTIC (NSC-45388) in the chemotherapy of sarcomas. | DTIC was one of the first of several new agents evaluated by the Southwest Oncology Group (SWOG) and the M.D. Anderson Hospital and Tumor Institute (MDAH) in the therapy of adult patients with metastatic sarcomas. It yielded an overall response rate of 17%. This is similar to that seen in a review of 138 patients who r... | 769,974 | [
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Prevalence of hypertension in a renal transplant population on alternate-day steroid therapy. | A study of the prevalence of hypertension in a group of renal transplant patients on alternate-day maintenance steroid therapy was conducted. Twenty-four percent of the transplant clinic population was hypertensive. The factors that were associated with a lower prevalence of hypertension were good graft function, bilat... | 770,034 | [
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Clinical assessment of azapropazone in rheumatoid arthritis. | Azapropazone was investigated in a 2-week double-blind clinical out-patient trial against placebo in 23 patients with definite rheumatoid arthritis. The drug was given at a dose of 1200 mg. per day before food. At this dose level the drug was shown to have an antirheumatic effect in terms of pain relief, articular tend... | 770,079 | [
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Prolonged treatment with azapropazone. | In an open study of 40 patients with chronic rheumatoid polyarthritis, azapropazone was given alone in daily doses between 1200 mg. and 1800 mg. over a period of 6 months. Six patients were withdrawn, 2 because of side-effects (1 with an allergic-type rash; 1 with ankle oedema) and 4 because azapropazone alone did not ... | 770,084 | [
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... |
Clinical use of immunosuppressive drugs: part I. | While immunosuppressive drugs are principally used in the treatment of malignant disease, their use in non-malignant disease and transplantation has become commonplace. The mechanisms of action of immunosuppressive agents differ. Alkylating agents react with nucleophilic centres of D, and rna. Folic acid antagonists pr... | 770,131 | [
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[Amitriptyline in psychiatric therapeutics. Apropos of 8 years of its use in hospital practice]. | A hundred and thirty patients have been treated with Amitriptylin in the "Clinique de Psychiatrie" in Marseille during the last eight years. The review of the hundred cases for which the information are the most detailed show that Amitriptylin remains one of the most powerful, manageable and well-tolerated anti-depress... | 770,151 | [
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... |
The major proteins of the Escherichia coli outer cell-envelope membrane. Heterogeneity of protein I. | One of the major proteins of the Escherichia coli outer cell envelope membrane, protein I, can be separated electrophoretically into protein components Ia and Ib. Strain differences exist regarding presence or absence of component Ib and this component can selectively be lost by mutation to resistance against a phage. ... | 770,169 | [
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Functional hybrid enzymes reconstituted from Escherichia coli and Serratia marcescens RNA polymerase subunits. | RNA polymerase was isolated from Escherichia coli and Serratia marcescens. The subunits of both enzymes were separated by electrophoresis on cellulose acetate sheets in the presence of urea. Under conditions favouring reconstitution of the RNA polymerases, stoichiometric amounts of the subunits were allowed to interact... | 770,171 | [
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Labelling of L-isoleucine tRNA ligase from Escherichia coli with L-isoleucyl-bromomethyl ketone. | L-Isoleucine: tRNA ligase from Escherichia coli could be irreversibly inactivated by L-isoleucyl-bromomethyl ketone but not by L-isoleucyl-chromethyl ketone. The inactivation rate exhibited a saturation concentration dependence typical for an affinity reagent. L-Isoleucine provided 100% protection against inactivation ... | 770,172 | [
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Membrane hybridization by centrifugation analysed by lipid phase transitions and reconstitution of NADH-oxidase-activity. | A procedure is described to hybridize cytoplasmic membranes of Escherichia coli. The method involves high-speed contrifugation of two different vesicle preparations at 37 degrees C in the presence of cations such as spermine or Mg2+. The occurrence of hybridization is shown by the following experiments. Firstly, format... | 770,174 | [
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Factors affecting the release of folded chromosomes from Escherichia coli. | 1. The envelope-bound folded chromosome prepared by gentle lysis of Escherichia coli K 12 DG 75 cells in the presence of 1.0 M sodium chloride was found to be a non-specific complex of DNA strands entangled in vesicle-like envelope structures. This envelope remnant is still more or less rod-shaped. 2. Both the envelope... | 770,175 | [
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Dryander of Marburg's woodcut (the oldest transposition?) | A sixteenth century woodcut depicting atypical congenitally corrected transposition is described. The possibility that the artist saw an example of the condition is considered in the light of Galen's theory of the circulation. | 770,178 | [
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Animal models of diabetes and obesity, including the PBB/Ld mouse. | Diabetes mellitus occurs in many animals species. However, only a few have been utilized in systematic studies designed to answer unsolved problems associated with the disorder in man such as molecular basis, pathogenesis of the vascular and neural lesions, and the roles of diet, exercise and obesity. Among the animal ... | 770,197 | [
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Maintenance of a constant brain extracellular potassium. | The development of potassium specific ion exchanger microelectrodes has enabled investigators to measure directly brain extracellular potassium ion activity. Although serum potassium in various species ranges between 3.5 and 6 mEq/l, brain extracellular potassium is maintained at a level close to 3 mEq/l independent of... | 770,198 | [
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Events at the cardiac sarcolemma: localization and movement of contractile-dependent calcium. | At present there is a controversy about the appropriate model for excitation-contraction (E-C) coupling in mammalian heart muscle. There is an apparent conflict between the data derived from voltage clamp experiments and data derived from isotopic exchange studies. The maximum transsarcolemmal Ca influx as derived from... | 770,200 | [
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Ultrastructural aspects of activation and contraction of vascular smooth muscle. | Ultrastructural studies of potential intracellular calcium storage sites and of the organization of contractile proteins in vascular smooth muscle are reviewed. The sarcoplasmic reticulum (SR) is a system of closed tubules present in every smooth muscle examined. The volume of the SR varies in different smooth muscles ... | 770,202 | [
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A prospective controlled trial of azathioprine in primary biliary cirrhosis. | Between 1968 and 1974, azathioprine has been used in a controlled prospective trial to treat patients with symptomatic but precirrhotic primary cirrhosis. Forty-five patients were admitted, of whom 22 were given azathioprine in a dose of 2 mg per kg of body weight. During the 1st year, serum aspartate transaminase leve... | 770,224 | [
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0.514643,
-0.06457328,
0.02797247,
0.1321... |
Terminal redundancy heterozygotes involving the first-step-transfer region of the bacteriophage T5 chromosome. | Individual progeny of two-factor crosses between A1am and A2am T5 phages give rise to bursts containing more than one type of plaque. The simplest explanation for these mixed bursts is that the A1 and A2 genes are located within the terminally repeated portion of the T5 genome and that the mixed bursts are made by "ter... | 770,228 | [
-0.2720594,
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-0.2598159,
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0.5379271,
0.05014028,
-0.2197684,
... |
UV mutagenesis in radiation-sensitive strains of yeast. | The yeast Saccharomyces cerevisiae appears to possess a single mutagenic or "error prony" pathway for the repair of UV damage; rev1, rev2, rev3 (Lemontt 1971a), rad6, rad8, rad9 and rad18 (Lawrence et al. 1974; present results). Strains carrying rad6 are the most sensitive to the lethal effects of UV light in this grou... | 770,231 | [
0.1031127,
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0.003385382,
0.2918157,
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0.2752938,
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0.2679277,
0.1798061,
0.3723412,
0.2895732,
0.009047366,
... |
5-Hydroxytryptophan (5-HTP) and a MAOI (nialamide) in the treatment of depressions. A double-blind controlled study. | Through a controlled double-blind study in 30 hospitalized patients affected with endogenous depression, the antidepressant action of the combination of nialamide+l-5-HTP has been evaluated and compared with a control group which only received nialamide (+ placebo). The patients treated with nialamide + l-5-HTP achieve... | 770,365 | [
-0.2282043,
0.1016334,
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0.1663709,
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0.2140196,
-0.112511... |
A computer program for the localization of small areas in roentgenological images. | A method and associated algorithm are presented which allow a simple and accurate determination to be made of the location of small symmetric areas presented in roentgenological images. The method utilizes an operator to visually spot object positions but eliminates the need for critical positoning accuracy on the oper... | 770,390 | [
0.03362031,
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0.2218273,
0.1804814,
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... |
Threonine deaminase from a nonsense mutant of Escherichia coli requiring isoleucine or pyridoxine: evidence for half-of-the-sites reactivity. | The mutant IP7 of Escherichia coli B requires isoleucine or pyridoxine for growth as a consequence of a mutation in the gene coding for biosynthetic threonine deaminase. The mutation of IP7 was shown to be of the nonsense type by the following data: (1) reversion to isoleucine prototrophy involves the formation of exte... | 770,416 | [
-0.1848416,
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0.03353558,
0.2611003,
0.4448636,
0.188039,
0.4265033,
-0.04243188,
0.0826... |
Regulation of purine utilization in bacteria. VI. Characterization of hypoxanthine and guanine uptake into isolated membrane vesicles from Salmonella typhimurium. | Uptake of hypoxanthine and guanine into isolated membrane vesicles of Salmonella typhimurium TR119 was stimulated by 5'-phosphoribosyl-1'-pyrophosphate (PRPP). For strain proAB47, a mutant that lacks guanine phosphoribosyltransferase, PRPP stimulated uptake of hypoxanthine into membrane vesicles. No PRPP-stimulated upt... | 770,425 | [
-0.486192,
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0.2197935,
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0.3462413,
0.2405567,
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... |
Mode of replication of the conjugative R-plasmid RSF1040 in Escherichia coli. | Replicating deoxyribonucleic acid (DNA) molecules of plasmid RSF1040, a deletion mutant of the conjugative R plasmid R6K, appear in the electron microscope as partially supercoiled structures with two open circular branches of equal size, although open structures with three branches, two branching points and no superco... | 770,431 | [
0.07817048,
0.2806556,
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0.1250122,
0.02713707,
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0.4917286,
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0.00395523,
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0.1031158,
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0.1401675,
-... |
Mapping of two loci affecting the regulation of branched-chain amino acid transport in Escherichia coli K-12. | Two mutant loci resulting in derepression of, respectively, the L-leucine-specific transport system (lstR) and both the leucine-specific and the general branched-chain amino acid transport LIV-I systems (livR) were mapped by conjugation and transduction. Both livR and lstR were found to be closely linked to aroA at min... | 770,444 | [
-0.1435909,
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0.2254871,
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0.1806176,
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0.936178,
0.3133466,
-0.1670257,
... |
Extragenic suppression of two ribosomal protein cistrons lying near the rif locus in Escherichia coli. | The experiments reported here involve temperature-sensitive mutations in two of five cistrons encoding 50S ribosomal proteins that lie near the rif locus in Escherichia coli. I selected spontaneous TS+ mutants able to grow at elevated temperatures in which the TS+ event takes place outside this tract of cistrons near r... | 770,447 | [
0.1398799,
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0.03167983,
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0.1738102,
-0.2516309,
0.2745895,
0.2030166,
-0.07260... |
Centrifugal separation of irradiated cultures of Escherichia coli cells into viable and nonviable populations. | Incubation of ultraviolet-irradiated Escherichia coli B/r cultures with 0.7% Triton X-100 resulted in a large decrease in turbidity. Under phase-contrast optics, most of the irradiated detergent-treated cells were smaller than normal and of low phase density; only a small percentage were normal or larger than normal an... | 770,460 | [
-0.07798389,
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-0.28834,
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0.1200206,
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0.06819721,
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0.2909256,
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0.02419803,
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0.2424121,
0.6216607,
0.2380361,
-0.007383... |
In vivo methylation by Escherichia coli K-12 mec+ deoxyribonucleic acid-cytosine methylase protects against in vitro cleavage by the RII restriction endonuclease (R. Eco RII). | We have analyzed the susceptibility of the deoxyribonucleic acid (DNA) of phage fd replicative form (RF) and of Escherichia coli to in vitro cleavage by purified RII restriction endonuclease (R. Eco RII). The results are summarized as follows: (i) fd, mec- RFI, isolated from infected E. coli K-12 mec- bacteria (a mutan... | 770,462 | [
-0.4170306,
0.07817687,
-0.2343091,
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0.07921741,
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0.1033625,
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0.0673863,
0.2896927,
0.3098931,
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0.1666199,
0.002599066,
0.128808,
0.1055046,
0.08517814,
-0.3535345,
-... |
Visualization of stimulated nerve endings by preferential calcium accumulation of mitochondria. | Calcium was detected by X-ray microanalysis in the mitochondria of electrically stimulated nerve endings. The phenomenon described here offers a simple means for identifying the stimulated nerve endings in the electron microscope and appears to be a promising new method for following spontaneous and drug-stimulated tra... | 770,484 | [
-0.04956522,
0.0556429,
-0.1986453,
0.0590895,
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0.1075596,
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0.04113535,
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0.01573978,
-0.2673108,
0.07555459,
-0.04717035,
0.1285003,
0.4492002,
0.1906752,
0.187952... |
Gonadotropin output and response to LRH administration in congenital virilizing adrenal hyperplasia. | Three premenarchial, 2 primary amenorrheic, and 5 post-menarchial patients with congenital virilizing adrenal hyperplasia (CAH) were examined, utilizing frequent blood sampling techniques and the administration of synthetic luteinizing hormone-releasing hormone (LHRH) to determine whether a normal pattern of gonadotrop... | 770,494 | [
-0.2173534,
-0.2195893,
-0.5059758,
-0.3815909,
-0.07470648,
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0.1088527,
0.2414071,
0.1514102,
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0.1337498,
0.3570528,
0.1481327,
-0.1085677... |
Cariogenic flora: establishment, localization, and transmission. | The foregoing is a review of current information on various aspects of the development of the cariogenic flora and it illustrates some of the complexities involved. The multifactorial nature of dental caries makes it necessary to look at this disease in a special way. Etiologic forces represented by a complex bacterial... | 770,522 | [
0.0833144,
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0.2567174,
0.2797597,
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0.1396417,
0.1105709,
0.02037378,
0.07527333,
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0.137645,
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0.1369924,
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-0.122245,
0.3076813,
0.173741,
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0... |
Streptococcus mutans serotypes: some aspects of their identification, distribution, antigenic shifts, and relationship to caries. | For an immunologic point of view, several facts are worth consideration. S mutans can be separated into at least seven serotypes. Five of the types are based on antigens that may be specific for S mutans. One type, e, is related to the Lancefield group E streptocci, and one type, f, may lack an antigen that shows serol... | 770,523 | [
0.04166094,
0.3686335,
0.09487534,
0.09559123,
0.02908476,
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0.1157937,
0.1682163,
0.03924996,
0.3740877,
0.3278788,
-0.04129307,
0.0... |
Susceptibility of mice to group B coxsackie virus is influenced by the diabetic gene. | A positive correlation was found between genetic predisposition to diabetes in the mouse and susceptibility to group B Coxsackie virus in this host. Male mice of the inbred strain C57BL/Ks and the following genetic variants were used; mice homozygous for the autosomal recessive gene for diabetes (db/db), the phenotypic... | 772,154 | [
0.02176253,
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0.07206362,
0.04499684,
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0.3917719,
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-0.002910827,
0.1576509,
0.2478774,
0.06743441,
0.1680335,
0.02574724... |
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