title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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46, X,X-X terminal rearrangement/45, X mosaicism in a child with short stature. | A phenotypically female child, investigated because of short stature, had abnormally large, often bipartite Barr bodies and a mosaicism of 45, X cells and cells with 46 chromosomes which included an exceptionally large metacentric chromosome (Xp+). G- and C-banding established that the chromosome was derived from two s... | 837,561 | [
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The 9p- deletion syndrome. A patient with a 45, XX-9, -15, +t(9/15) constitution due to maternal 3:1 meiotic disjunction. | Deletion of the short arm of chromosome 9, derived from a 3:1 meiotic segregation in the mother, carrier of a balanced 9/15 translocation, was found in a 3-year-old female. Severe psychomotor retardation with delayed speech, brachicephaly, flat occiput hypertelorism and long upper lip were the main signs in the girl. | 837,573 | [
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Congenital idiopathic clubfoot. | Using a relatively conservative approach to the problem, the results were fair to good in two-thirds of the patients in a series of 23 congenital idiopathic clubfeet with an average follow-up of 6 and one-half years. | 837,595 | [
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The use of the Varney brace for subluxating shoulders in stroke and upper motor neuron injuries. | Applying the Varney shoulder brace for painful subluxating shoulders in stroke and head injury patients with or without spasticity has proved to be an extremely effective means of reducing the subluxed shoulder. Other causes for painful shoulders in these patients must be ruled out. Not every shoulder which subluxes wi... | 837,609 | [
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Barton's fractures-reverse Barton's fractures. Confusing eponyms. | Anterior and posterior marginal fracture dislocations of the distal radius are unusual injuries, both of which are called Barton's fracture in the current world literature. Barton's original description delineates only the posterior marginal injury. An attempt is made to clarify the nature of these injuries by a comple... | 837,611 | [
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Preschool developmental testing in prediction of school problems. Studies of 55 children in Denver. | Sixty-five children from lower income families, first evaluated with the Denver Developmental Screening Test (DDST) and the Stanford-Binet Intelligence Scale at age 4 to 6 years, were followed up 3 years later to determine how well preschool test results could predict later school problems. Eighty-eight per cent of chi... | 837,629 | [
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Studies on digitalis. VIII. Digitoxin metabolism on a maintenance regimen and after a single dose. | The metabolic pattern of cardioactive and inactive conjugated metabolites of digitoxin on maintenance (9 patients) and after a single 0.6-mg dose (5 patients) was studied in patients with normal renal and hepatic function. Serum samples were obtained 24 hr after the last dose, and urine was collected over 24 hr. The ex... | 837,632 | [
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Conservative management of pes valgus with plantar flexed talus, flexible. | The type of flat foot that we have called pes valgus with plantar flexed talus, flexible, was treated in children with the Helfet heel seat or the UCBL shoe insert. In follow-up examination of 71 cases for periods longer than one year, 79 per cent of the patients showed that the UCBL shoe insert and the Helfet heel sea... | 837,624 | [
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Depression of renal clearance of furosemide in man by azotemia. | The renal clearance of furosemide and tetraethylammonium (TEA) were compared in 10 patients with hypertensive nephropathy. BUN and creatinine ranges were 10 to 88 mg/dl and 0.9 to 3.8 mg/dl, respectively. Diuretics were discontinued 48 hr prior to the study, and 2 consecutive clearances (ml/min/1.73 m2BSA) of creatinin... | 837,633 | [
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Perilesional vitiligo in melanoma. | The malignant transformation of a plantar nevus is presented. Perilesional vitiligo developed concurrently with the onset of malignancy. The primary lesion was controlled surgically, but the patient succumbed to metastiatic melanoma within a year. The relation of perilesional vitiligo in malignant melanoma to the so-ca... | 837,717 | [
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Myiasis Dermatobia hominis, Linn: report of a case and review of the literature. | A description of the life cycle of the tropical botfly, Dermatobia hominis, is presented. The entomology of this parasite is discussed along with the pathologic manifestations of human infestation and a description of the various modes of treatment. A recent case of multiple botfly infestation in a young man during a ... | 837,719 | [
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Bowen's Disease of the Finger. | Four cases of Bowen's disease of the finger have been treated, three during the past two years. This form of carcinoma-in-situ should be considered in the differential diagnosis of any persistent scaly and/or crusted lesion of the finger. Bowen's disease in this particular site may be more common than the literature su... | 837,726 | [
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The electrocardiographic response to maximal treadmill exercise of asymptomatic men with right bundle branch block. | This study presents the results of maximal treadmill testing and cardiac catheterization in 40 asymptomatic and apparently healthy men with acquired right bundle-branch block. Eight of the men had significant angiographic coronary artery disease, and six of the eight only had single-vessel disease. The 40 men had norma... | 837,747 | [
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Silicosis in slate pencil workers. A clinicoradiologic study. | We present a study of 151 persons working in slate-pencil manufacturing industries located in the Mandsaur district of Madhya Pradesh, India. Cough, dyspnea, and pain in the chest were the important symptoms. Cyanosis, rhonchi, and crepitations were found in varying numbers of cases. The chest x-ray films were abnormal... | 837,763 | [
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[Persistent duodenal septum in an adult]. | A case of duodenal obstruction by a congenital duodenal web in a 34-year-old woman is presented. A mucosal diaphragm obstructed the duodenum. It showed an excentric opening of 0.8 cm diameter, but the dilated diaphragm caused a total stop during the last months. Despite a typical history, exact X-ray, and endoscopic ex... | 837,796 | [
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An investigation of some problems concerning nucleolus organizers in salamanders. | Observed differences in the sizes of lampbrush nucleolus organizers in Plethodon cinereus have been shown by in situ hybridization to reflect true molecular differences in the numbers of ribosomal cistrons located at these organizers. Likewise, from in situ hybridization experiments on lampbrush and spermatocyte chromo... | 837,805 | [
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Preoccupation with death in schizophrenic men. | A systemic review of psychiatric histories of 205 hospitalized, schizophrenic men (veterans) revealed that 80 had expressed fear of dying, being killed, of no longer existing, or other evidence of preoccupation with death. These expressions of fear appeared either at the clinical onset of the psychosis, or during exace... | 837,823 | [
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[Children of mothers with phenylketonuria (author's transl)]. | Microcephaly and considerable motor and mental retardation occurred in two non-phenylketonuric children of an untreated mother with phenylketonuria. The cerebral damage of the children must be considered the consequence of the maternal metabolic disorder. Since the first phenylketonuric children who were treated on str... | 837,853 | [
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Appearances of responses to glucagon in cultured neoatal rat heart cells. | Heart cells from neonatal rats have been cultured. The ability of 10(-5)M glucagon to stimulate adenylyl cyclase activity, and to increase the cAMP concentration and the beating rate in these cells was followed as a function of time in culture. The cultured cells show no response to 10(-5)M glucagon until 5 weeks. By c... | 837,888 | [
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A clotting defect in an Arab colt foal. | A multiple clotting defect in a 3 month old Arab colt foal associated with a deficiency in Factors VIII, IX, and XI is described. No abnormalities in clotting factors were detected in the colt's sire, dam, half-sister and half-brother. | 837,896 | [
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Properties of a baby-hamster-kidney cell line with increased resistance of 2-deoxy-D-glucose. | A cultured cell line with increased resistance to 2-deoxy-D-glucose was obtained from cloned baby hamster kidney fibroblasts, BHK 21/C13, after repeated exposure to high concentrations of 2-deoxyglucose. The increased resistance could not be attributed to a decreased permeability of deoxysugar. The resistant cell line ... | 837,919 | [
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Forms AI and AII DNA-dependent RNA polymerases as components of two defined pools of polymerase activity in mammalian cells. | Two species of form A (or I) RNA polymerase have been identified in eucaryotic cells and there is evidence that this alpha-amanitin-insensitive activity exists as two discrete pools: a pool of 'free' activity, which is identified by its ability to transcribe poly d(A-T) in the presence of actinomycin in vitro, and a po... | 837,929 | [
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Covalent structure of collagen: isolation of chymotryptic peptides and amino acid sequence of the amino-terminal region of alpha2-CB3 from chick skin. | Five chymotryptic peptides were isolated from alpha2-CB3 of chick skin collagen by a combination of ion-exchange and molecular sieve chromatography. Together, they account for the entire amino acid content of the parent peptide. Their alignment was deduced by isolation and sequence analyses of overlapping tryptic pepti... | 837,937 | [
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Digoxin elimination by exchange transfusion. | The report covers four cases presenting simultaneous indications for digitalisation and exchange transfusions. Intravenous administration of digoxin was followed: 1. by monitoring of the behaviour of the plasma digoxin level; 2. by determination of the total amount of glycoside eliminated by the blood exchange. Particu... | 837,948 | [
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Nonspecific immunotherapy with BCG vaccine in bladder tumors: a preliminary report. | The therapeutic and prophylactic value of nonspecific immunological stimulation with BCG vaccine against papillary bladder carcinomas has been evaluated. Nine patients were treated and followed for periods of 4-9 months. Attempts have been made to compare the effects of BCG vaccine administered via dermal scarification... | 837,949 | [
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Transrectal ultrasono-tomography. | A relatively simple and painless technique of transrectal ultrasono-tomography is presented. It constitutes a reliable and objective adjuvant to the determination of size and possible infiltration of prostatic and bladder tumours in the human. | 837,953 | [
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Effect of dexamethasone on monoamine oxidase inhibiton by iproniazid in rat brain. | Chronic (6 days) dexamethasone administration caused a slight decrease of rat brain MAO enzyme activity which was reflected by lower levels of 14C-homovanillic acid (HVA) and increased levels of 14C-3-methoxytyramine (3MT) following intracisternal injections of 14C-dopamine (DA). Opposite results with dexamethasone wer... | 837,973 | [
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Nutrient transport systems in dog brain. | The cerebral circulation of the dog was isolated and an extracorporeal system was used to perfuse the brain with diluted blood. Transport of blood-borne substances was investigated by measurement of arteriovenous (a-v) differences (net transport) and by the indicator dilution method (unidirectional influx). The net mov... | 838,084 | [
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0.08706801,
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0.09796274,
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-... |
Comparative effect of food on absorption of ampicillin and pivampicillin. | The effect of food on the absorption of simultaneously ingested ampicillin or pivampicillin was compared in a crossover study in eight healthy volunteers. The absorption of both ampicillin and pivampicillin was delayed by simultaneous food intake as judged by serum concentration and urinary excretion of ampicillin. The... | 838,114 | [
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The encephalitogenicity of the Hempt vaccine. | The encephalitogenic property of rabies vaccines of brain tissue origin (Hempt vaccine produced in different institutes, Semple vaccine, International Standard of Rabies Vaccine) was studied in animal experiments. Guinea pigs inoculated with the vaccines in complete Freund adjuvant were observed for clinical signs and ... | 838,141 | [
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... |
Detection of endotoxin in biological products by the limulus test. | The limulus amebocyte lysate (LAL) test is established as a beneficial quality assurance measure for the parenteral drug industry because of its sensitivity, specificity, and simplicity. Limulus amebocyte lysate reacts with various forms of endotoxin to form an opaque gel under acceptable conditions of pH, temperature,... | 838,151 | [
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Retinopathy and plasma growth hormone levels in idiopathic hemochromatosis with diabetes. | In patients with idiopathic hemochromatosis, retinopathy was investigated by ophthalmoscopy and fluorescein angiography and was present in eight out of 23; this prevalence is similar to that reported in patients with diabetes aged between 30 and 60 years at onset of diabetes and with the same duration of the disease; i... | 838,164 | [
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Failure of lactose and glucose to influence in vivo intestinal calcium transport in normal rats. | The influence of luminal lactose and glucose on intestinal calcium transport was examined in vivo in normal post-weaned young rats. In situ segments of duodenum, midgut and ileum were perfused through the lumen for 1 h with an isotonic solution of 3.4 mM calcium containing radioactive isotopic 45Ca as tracer and additi... | 838,174 | [
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Gastroduodenostomy in dogs with and without parietal cell vagotomy. Effect upon gastric emptying and motility, Heidenhain pouch acid secretion and serum gastrin concentration. | Heidenhain pouch (HP) dogs were studied. After gastroduodenostomy (GD) gastric emptying time was unaffected, but cineradiography showed that the strength of the antral contractions diminished considerably, while the number of peristaltic waves increased. "Circus movements" of the barium meal through the GD to the duode... | 838,181 | [
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Non-parallel response of amylase and chymotrypsinogen biosynthesis following pancreatic stimulation: a possible explanation for observed non-parallelism in pancreatic secretion. | The response of amylase and chymotrypsinogen to a pancreatic secretory stimulation (intragastric administration of oleic acid or sodium oleate) are compared in rats. This comparison concerned the rates of biosynthesis of the two enzymes, their intrapancreatic levels of storage and their rates of excretion in the juice.... | 838,183 | [
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... |
HLA-types, C-peptide and insulin antibodies in juvenile diabetes. | HLA-types were determined in 102 juvenile diabetics. HLA-B8 was found in 39 patients (RR 2.64; p less than 0.01) and HLA-BW15 in 32 patients (RR 1.33; n.s.). HLA-B7 was found in 14 patients (RR 0.40; p less than 0;05). There were no correlations between HLA-B8 or BW15 and family history of diabetes, occurrence of infec... | 838,199 | [
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... |
Factors affecting bilirubin excretion in patients with cholesterol or pigment gallstones. | To identify factors affecting bilirubin excretion, the effects of bile flow and bile salt excretion on bilirubin output into bile have been examined in normobilirubinemic, cholecystectomized patients with balloon-occludable, reinfusion T-tubes, 8 patients with cholesterol (CS) and 2 with pigment (PS) gallstones. Anothe... | 838,216 | [
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... |
Minimal bile acid malabsorption and normal bile acid breath tests in cystic fibrosis and acquired pancreatic insufficiency. | This study was undertaken because of reports of a marked increase in fecal bile acid excretion by children with cystic fibrosis. We attempted to confirm this finding by performing [1-14C]cholylglycine breath tests and by measuring fecal bile acid and fat excretion in patients with cystic fibrosis and acquired pancreati... | 838,220 | [
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Effects of catecholamines and their inhibitors on the isolated canine pancreas. II. Dopamine. | Dopaminergic agonists (dopamine, 2, 10, 50, and 250 mug; apomorphine, 1 mg; noradrenaline, 2, 20, and 200 mug), and inhibitors (haloperidol, 5 mg; pentamethonium, 500 mg; phenoxybenzamine, 15 mg, and atropine sulfate, 10 mg), were tested on isolated perfused canine pancreas; under basal conditions and under stimulation... | 838,228 | [
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0.135... |
Salicylate hepatitis. | Two patients developed acute hepatic injury as a result of salicylate therapy. In each patient serum salicylate levels were below 25 mg per 100 ml during the development of hepatic dysfunction. Liver biopsies, obtained a few days after the peak abnormalities in serum transaminases, revealed nonspecific acute hepatitis.... | 838,229 | [
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[Lymphografy--a meaningful diagnostic method for classification of gynaecological tumours (author's transl)]. | The data about the significance of lymphografy vary between 50% and 90%. The histological findings of the lymphnodes by patients with carcinoma of the cervix uteri operated according to the method of Wertheim-Meigs showed that the findings of lymphografy agree in 68% of the cases with the histological ones. An agreemen... | 838,264 | [
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0... |
The special problems of heart disease in old people. | The major difference between heart disease in the old and the young is that elderly people almost have one or more other major, even life-threateninng conditions. These associated diseases challenge the physician in establishing a diagnosis and prognosis, understanding the pathogenesis of the symptoms and signs, and de... | 838,277 | [
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Influence of age and different drugs on the healing process in human skin wounds. | The paper contains the results the authors obtained when following, by means of electron-microscopic examination, the healing process of skin specimens after tetracyclin and hydrocortisone administration with regard to age. The results were compared to those in experiments, in which the healing of skin wounds in animal... | 838,284 | [
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Gastric histology and its relation to anaemia in the elderly. | During 1 year 725 consecutive patients admitted to a geriatric unit were investigated for anaemia. 51% of men had haemoglobin levels below 13.5 g/dl and 41% of women had levels below 12 g/dl. 657 patients had an azuresin tubeless test meal following an augmented dose of histamine acid phosphate and 450 (68%) had achlor... | 838,286 | [
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[Injuries and emergencies in othorhinolaryngology. Diagnosis and immediate therapy. 1. Injuries of the ear]. | Following the general discussion of the causes of accidents and emergencies in the ENT-field, important accident-situations are classified and explained according to anatomical criteria. The differential diagnostic aspects as well as possibilities of first aid are discussed. The most important aspect of first aid is to... | 838,421 | [
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[Model of intramedullary compression-osteosynthesis procedure for the humerus]. | A method of osteosynthesis is being tested for its effectiveness by means of physican and experimental study and animal research. This could make it possible to stabilize fractures of the humerus diaphysis safely with pressure produced intramedullary on the interfragmentary, that is to say through "Kompressions-Bündeln... | 838,440 | [
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0.2868735,
... |
[Syndrome of the unilateral or partially "hyperlucent lung"]. | The paper presents the picture of the unilateral or partial "hyperlucent lung" syndrome. The most common causes of this anomaly are described according to pathological and anatomical criteria. The difficult diagnosis of its X-ray-appearance is discussed. The value of differential diagnostic criteria is demonstrated in ... | 838,453 | [
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0.0626... |
CNS regulation of salt and water intake. | The brain has evolved a number of mechanisms to maintain body fluid balance. They include the sensation of thirst, which stimulates water intake, the secretion of vasopressin, which helps prevent water loss, and the secretion of aldosterone, which helps prevent sodium depletion. In the research described here, all thre... | 838,497 | [
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Plasma cells in vertebrate paraocular glands. | The Harderian and lachrymal glands of eight mammals and two reptiles were examined histologically for plasma cells and the extent of infiltration compared to that in the Harderian gland of the fowl. Moderate accumulations were observed in one or both glands of the goat, sheep, cow, horse, dog and pig, but only few cell... | 838,515 | [
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... |
Long-term administration of DDT or phenobarbital-Na in Wistar rats. | In lifespan studies, outbred male and female Wistar rats were given either technical DDT mixed into the diet at a dose of 500 parts per million (ppm) or phenobarbital-sodium dissolved in drinking water at a dose of 500 ppm. Liver-cell tumors developed in treated animals but not in controls. The incidence of liver tumor... | 838,519 | [
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Cellular effects of combined adriamycin and x-irradiation in human tumor cells. | The effects on cell survival in tissue culture of Adriamycin, of various Adriamycin derivatives and of the parent compound, daunomycin, have been studied. Adriamycin and three of its C-14 derivatives show similar toxicities towards cells chronically exposed in culture. Acute (30 min) exposures are significantly less to... | 838,520 | [
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... |
Interaction of tolbutamide and chloramphenicol in diabetic patients. | In study 1 we investigated 8 diabetic female patients treated with tolbutamide who received chloramphenicol to combat urinary tract infections. In 5 patients, chloramphenicol was found to produce a distinct decrease of glycemia. Evaluation of the whole series revealed that the latter averaged 31.5%. No patient develope... | 838,527 | [
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Focal spots: II. Models. | A new "smeared filament image" focal spot model is suggested. This model and previous models are compared to experimental results. It is found that the proposed model fits the experimental data in a self consistent and accurate manner. The rectangular model also gives satisfactory results in situations where the focus ... | 838,558 | [
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Focal spots: III. Field characteristics. | Experimental results for focal spot field characteristics are presented. These results do not agree completely with results published by Moores and Roeck but are in agreement with Doi's theory as applied to separable focal spots. A new image plane origin called the principal ray is proposed. The variation of the star t... | 838,559 | [
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Focal spots: I. MTF separability. | Focal spot models have been based on the implicit assumption that the two dimensional MTF is mathematically separable in the form P(u, v) = P(u)P(v). Experimental results for nine foci are presented. It is concluded that the assumption of separability can be used without introducing a large error. As a consequence of t... | 838,556 | [
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[Skin syphilids, only incidental findings]. | Six cases of syphilides- rarely seen cutaneous manifestations today--are reported and the difficulties in finding the correct diagnosis are stressed. Considerations with particular reference to the differential diagnosis of clinically and histomorphologically similar diseases are discussed. Beside case history and sero... | 838,578 | [
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0.1226708,
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0.05049752,
0.02580083,
0.2199783,
0.3864321,
0.004615364,
-0.02... |
[Malignant granular cell tumor]. | A case of malignant granular cell tumor is reported. A 44-year-old male patient presented a tumor starting from the left side of the neck which finally extended shoulder and left thoracic region. Despite repeated gammatron radiations and cytostatic therapy death occurred three years after the discovery of the primary t... | 838,580 | [
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0.1842487,
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[Spontaneously occuring and experimentally induced enzymatic changes in the rat parotid gland: a possible experimental model of ageing (author's transl)]. | The activity, specificity and stability of many enzymes decreases in ageing organisms. This fact is attributed to the accumulation of errors in protein biosynthesis. Due to its very active protein metabolism, the parotid gland is a suitable experimental model for the investigation of such age-dependent processes. By ad... | 838,610 | [
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0.09268449,
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A new aminoglycoside antibiotic complex--the seldomycins. I. Taxonomy, fermentation and antibacterial properties. | A soil isolate named Streptomyces hofunensis sp. nov. was found to produce seldomycin factors 1, 2, 3 and 5, new aminoglycoside antibiotics. Taxonomy of the producing organism, a study of cultural conditions for seldomycin production, and antibacterial activity of seldomycins are reported. Seldomycin factor 5 was the m... | 838,628 | [
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0.02588499,
0.09166... |
Hemodynamic response to graded exercise after chronic beta-adrenergic blockade. | The effect of sustained beta-adrenergic blockade (BB) on the hemodynamic response to graded exercise has been studied in 31 patients with high blood pressure. Hemodynamic investigations were conducted during a control period and were repeated after 1 mo of BB. Similar readjustments were observed at rest and during subm... | 838,637 | [
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0.0783849... |
Mechanism of change in pulmonary shunt flow with hemorrhage. | In the presence of regional atelectasis, hemorrhage increases the pulmonary shunt fraction (Qs/Qt). We wanted to determine if the increase in Qs/Qt occurs due to inhibition of hypoxic vasoconstriction or due to hydrostatic effects associated with a collapsed lung and decrease in cardiac output. We compared the effects ... | 838,645 | [
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... |
Lung elasticity and airway dynamics in Peruvian natives to high altitude. | To evaluate the role of genetic and environmental factors in the genesis of large lungs in high-altitude natives, we measured forced vital capacity (FVC), static lung pressure-volume characteristics and maximum expiratory flow-volume loops in 17- to 20-yr-old Peruvian natives to 3,850 m (highlanders) and 800 m (lowland... | 838,649 | [
0.2423794,
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0.003847037,
0.04664458,
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0.2973655,
-0.33041... |
Interaction of lung volume and chemical drive on respiratory muscle EMG and respiratory timing. | The effect of increased FRC on the change in respiratory muscle electrical activity (EMG) and the duration of inspiration (Ti) and expiration (Te) produced by increases in chemical drive (i.e., progressive hypercapnia and isocapnic hypoxia) was assessed in 15 anesthetized, spontaneously breathing dogs. FRC was raised b... | 838,652 | [
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0.002289609... |
Combined effects of breathing resistance and hyperoxia on aerobic work tolerance. | Effects of three curvilinear inspiratory resistances (R1, R2, R3) on the cardiorespiratory responses of seven well-trained men during incremental cycling tests to exhaustion were studied by comparison to the low resistance R0 (at 1 l/s, R0 = 0.2; R3 = 6.5 cmH2O-s/l). Submaximal VO2 and the gas exchange anaerobic thresh... | 838,665 | [
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0.01908761,
0.09045... |
Measurement of mucociliary clearance from the trachea of conscious and anesthetized rats. | A technique is described whereby particles are injected as a suspension into the trachea of conscious rats. Tracheostomy and cannulation are performed under halothane, but the particles are injected 10 min after recovery. Clearance of BaSO4 particles labeled with 133Ba was determined with a collimated slit gamma-counte... | 838,667 | [
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Anodal block of medullated cardiopulmonary vagal afferents in cats. | In anesthetized cats examination was made of the conditions under which the application of DC current to a mixed nerve permits determination of whether a reflex response is mediated by medullated or nonmedullated afferents. The following precautions should be observed. The nerve must be stripped of its sheath and bleed... | 838,668 | [
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... |
Generation of a transmembrane electric potential during respiration by Azotobacter vinelandii membrand vesicles. | Membrane vesicles isolated from Azotobacter vinelandii strain O by lysis of spheroplasts in potassium of sodium phosphate buffer develop a transmembrane electric potential during respiration. The magnitude of this potential was determined by three independent methods: (i) fluorescence of 3,3'-dipropylthiodicarbocyanine... | 838,687 | [
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0.19539... |
Differentiation of metal ion-induced transitions of prothrombin fragment 1. | The intrinsic fluorescence of human and bovine prothrombin fragment 1 is quenched (approximately -35%) when calcium ions are bound. The intrinsic fluorescence of prothrombin is also quenched by the binding of Ca2+ but to a lesser extent (total change is approximately -6%). The prothrombin fragment 1 fluorescence transi... | 838,700 | [
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... |
Binding of concanavalin A to the surface of sea urchin eggs and its alteration upon fertilization. | The binding of concanavalin A (Con A) to Strongylocentrotus purpuratus eggs has been investigated using 125I-concanavalin A (125I-Con A). The lectin binds specifically to the egg surface and does not produce agglutination of the eggs. High 125I-Con A concentrations are necessary to saturate all of the surface binding s... | 838,717 | [
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Pyruvate metabolism in bovine epididymal spermatozoa. | Treating bovine epididymal spermatozoa with rutamycin or rotenone inhibited both respiration and motility supported by endogenous substrates. When oxidative phosphorylation had been blocked with various inhibitors, pyruvate was metabolized to yield ATP and restored motility. Fructose, which is metabolized via glycolysi... | 838,718 | [
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-... |
"Brown tumor" of hyperparathyroidism induced with anticonvulsant medication. | A case history is presented of a 50-year-old epileptic receiving massive dose of phenobarbital and small doses of dilantin. Following a minor injury to her forearm a "brown tumor" of hyperparathyroidism and osteomalacia, both of which responded to vitamin D.A review of the literature is given; this is the second case r... | 838,762 | [
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Gap junctions. Structural changes after uncoupling procedures. | The freeze-fracture appearance of rat stomach and liver gap junctions changes after uncoupling procedures such as inhibition of the metabolism of perfusion with hypertonic sucrose. In control stomach, either fixed immediately or kept for 1 h in a well-oxygenated Tyrode's solution at 37 degrees C, most gap junctions bet... | 838,770 | [
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Two fractions of rough endoplasmic reticulum from rat liver. II. Cytoplasmic messenger RNA's which code for albumin and mitochondrial proteins are distributed differently between the two fractions. | Subcellular fractions were obtained from rat liver homogenates under conditions which prevented degradation of polysomes (pH 8.5 and high ionic strength). Rough endoplasmic reticulum (RER) was recovered in high yields from a low-speed nuclear pellet (rapidly sedimenting endoplasmic reticulum, RSER) and from a postmitoc... | 838,773 | [
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0... |
Rapid decline thymidine kinase activity during differentiation of Naegleria. | A logarithmically growing population of Naegleria gruberi differentiate into flagellates synchronously in about 85 to 90 minutes after the stimulation. Using this system, two separate enzymes that phosphorylate thymidine were assayed. Thymidine kinase activity decreases rapidly after the stimulation, while nucleoside p... | 838,776 | [
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0.3368491,
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... |
Determination of the configurations of lactic and glyceric acids from human serum and urine by capillary gas-liquid chromatography. | The separation of the enantiomers of lactic and glyceric acids can be achieved by capillary gas chromatography on SP-1000 using the corresponding O-acetylated methyl esters. The structures of the derivatives were proved by proton magnetic resonance spectroscopy and mass spectrometry. The method has been used for the de... | 838,825 | [
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-... |
Renin reactivity in plasma of patients with normal renin and low renin essential hypertension. | Plasma renin reactivity (PRR) is the rate of angiotensin generation in vitro after addition of exogenous renin to plasma. To evaluate the hypothesis that suppressed plasma renin activity (PRA) in patients with low renin essential hypertension may be related to an alteration of the kinetics of the in vitro renin reactio... | 838,842 | [
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0.06434078,
0.01691667,... |
A variant of iodotyrosine-dehalogenase deficiency. | Three siblings (products of consanguineous marriage) affected with iodotyrosine-dehalogenase deficiency (presumed homozygotes) were found to have low thyroxine and large multinodular goiters, but none was mentally retarded. Iodide therapy corrected the serum T4 and thyroidal iodide uptake and discharge curve. The goite... | 838,849 | [
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Steady state hormonal secretion in traumatic quadriplegia. | Physiologically complete cervical spinal cord transection results in motor and sensory quadriplegia and interruption of the sympathetic neural pathways; this condition leads to metabolic deficiencies suggestive of abnormal endocrine function. An investigation of the non-stimulated secretion of some of the hormones infl... | 838,851 | [
0.0250218,
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0.4880466,
0.0872455... |
Measurement of pulmonary capillary blood flow in infants by plethysmography. | An accurate method for measuring effective pulmonary capillary blood flow (Qc eff) in infants has been developed with an adaptation of the plethysmographic technique. Measurements were made on 19 preterm. 14 small-for-dates, and 7 fullterm normal infants with a constant volume whole body plethysmograph in which the inf... | 838,861 | [
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0.264596,
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0.09199534,... |
Haemocytometry by laser-beam optics: evaluation of the Hemac 630L. | Hemac is an automated blood counting system which is based on production of impulses from light scattered and diffracted by cells flowing past a laser beam. The pulses are processed electronically for cell counts and packed cell volume; haemoblobin is measured as cyanmethaemoglobin; absolute values are computed. On eva... | 838,872 | [
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0.01744796,
-... |
A sensitive urine-test method for monitoring the ingestion of isoniazid. | A method is described for monitoring the ingestion of isoniazid based on detecting its metabolites, isonicotinic acid, and isonicotinylglycine in the urine. The sensitivity of the method is high so that reliably positive results were obtained up to about 24 hours after the ingestion of 100 mg isoniazid. The method shou... | 838,875 | [
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0.03516642,
0.09346022,
... |
Unmyelinated axons in thoracic ventral roots of the cat. | This study shows that approximately 30% of the axons in the T11 and T12 ventral roots of the cat are unmyelinated. The unmyelinated axons fall into two categories. Slightly less than half are efferents from the spinal cord and slightly more than half arise from dorsal root ganglion cells. The efferent fibers are regard... | 838,878 | [
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0.5004267,
0.009499... |
Quantitative studies of cell size in the cat's dorsal lateral geniculate nucleus following visual deprivation. | The effects of visual deprivation upon dorsal lateral geniculate (DLG) cell size were compared for seven kittens reared with monocular lid-suture (MD), seven with binocular lid-suture (BD), and six with one eye lid-sutured and the other eye enucleated soon after birth (MD-E). Six additional kittens were reared normally... | 838,882 | [
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0.2258595,
-... |
Regeneration of fungiform taste buds: temporal and spatial characteristics. | The gross morphology of the tongue of the Mongolian gerbil Meriones unguiculatus), the location of papillae and taste buds, and the normal innervation pattern of the tongue and taste buds were determined. The chorda tympani nerve was interrupted to produce degeneration of fungiform taste buds. Regenerating chorda tympa... | 838,892 | [
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0.3741477,
0.2962291,
0.011... |
Relatively brief environmental enrichment aids recovery of learning capacity and alters brain measures after postweaning brain lesions in rats. | Enriched postlesion experience aided in overcoming effects of simultaneous bilateral cerebral lesions made at 30 days of age in one experiment with inbred Fischer rats and in a second experiment with the Berkeley S1 strain. The lesions were directed to the occipital cortex, but in most cases there was also some impairm... | 838,916 | [
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0.2514614,
0.1890932,
0.2343761,
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The reaction of nerve tissue to various suture materials: a study in rabbits. | Adult, male white New Zealand rabbits were used to compare two new synthetic suture materials, polyglycolic acid (Dexon) and polypropylene (Prolene), with wire, plain catgut, and silk. The purpose of the study was simply to determine the reaction of nerve tissue to each of the five different materials. No attempt was m... | 839,053 | [
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... |
An improved method for the histochemical localization of glucose-6-phoshate dehydrogenase in animal and plant tissues. | An improved procedure is reported for the histochemical localization of glucose-6-phosphate dehydrogenase in fresh-frozen sections of animal and plant tissues. Used in this procedure are an incubation medium and an inert high-molecular-weight polyvinyl alcohol as a stabilizer to check enzyme diffusion. The incubation m... | 839,060 | [
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... |
Determination of RNA antibodies in serum and unconcentrated CSF by counterimmunoelectrophoresis. | A quantitative counterimmunoelectrophoresis technique has been applied to evaluation of RNA antibodies in serum and unconcentrated CSF. Serum anti-RNA antibodies have been found at high dilutions in some patients with infectious diseases, subacute panencephalitis and multiple sclerosis. RNA antibodies in CSF are signif... | 839,079 | [
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0.06224343,... |
The effects of indomethacin on long-wave ultraviolet-induced delayed erythema. | Indomethacin, a known inhibitor of prostaglandin synthesis, administered topically as a 2.5% solution, intradermally in 10 mug doses, and orally in a dose of 150 mg/day for 2 days did not diminish the delayed erythema produced a long-wave ultraviolet light (320-400 nm). The delayed phototoxic erythema produced by 8-met... | 839,086 | [
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0.1334073,
0.3115422,
0.01625216,
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... |
Regulation of plasma lecithin:cholesterol acyltransferase. II. Activation during alimentary lipemia. | The effect of dietary fat on plasma lecithin:cholesterol acyltransferase (LCAT) activity has been investigated in 14 normal male subjects. After determination of postabsorptive lipid and LCAT levels, a high-fat liquid test meal (1 to 2 gm./kg. body weight) was fed, followed by lipid and LCAT determinations at 2.5 hour ... | 839,110 | [
0.001266458,
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0.2123397,
0.01716957,
0.3500474,
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0.... |
Iodination by human polymorphonuclear leukocytes: a re-evaluation. | The conversion of iodide to a trichloroacetic acid-precipitable form (iodination) by polymorphonuclear leukocytes (PMN's) has been re-evaluated as a measure of neutrophil function. Optimum conditions are described which result in an iodination value for normal cells during the phagocytosis of zymosan of 64.1 +/- 13.2 (... | 839,126 | [
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0.3979951,
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0.3303094,
0.01... |
Temporal bone findings in the late stage of secretory otitis media. | The temporal bone findings in a patient with secretory otitis media are presented. One ear had been fitted with tympanostomy tubes for five and the other for three years. Before death the latter ear had been without a tube for two years. Histological study revealed secreting tympanic mucosa with a very high density of ... | 839,133 | [
-0.2943089,
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0.3847967,
0.1639278,
0.30... |
Developing behavioral science for a family practice residency. | The development of behavioral science in a family practice residency has first to be structured around a statement of purpose and adequate goals. These goals can only be implemented when the purely custodial function of the medical profession is rejected and the ethical responsiblity of the physician to society is allo... | 839,170 | [
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0.1453148,
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0.2487173,
0.02676304,
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0.1741482,... |
Inhibition of hamster sperm acrosome reaction and fertilization by oligomycin, antimycin A, and rotenone. | Effects of respiratory inhibitors (oligomycin, antimycin A and rotenone) on hamster sperm acrosome reaction and fertilization were studied. Hamster spermatozoa were incubated in a mixture of a modified Tyrode's solution and heat-treated human serum in the presence and absence of inhibitors. Oligomycin (2.4 x 10(-6) M),... | 839,182 | [
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0.004090044,
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0.4744011,
0.1179711,
-0.07341894,... |
The relationship between growth, developmental stage and postamputation age of the regeneration blasterma of the newt, Notophthalmus viridescens. | The growth of the regeneration blastema of the newt forelimb has been quantitated and analyzed as a function of postamputation age, developmental stage, animal weight, animal length, and cross sectional diameter of the blastemal base in both the anteroposterior and dorsoventral dimensions. Correlation coefficients comp... | 839,186 | [
-0.09027391,
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0.1397862,
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0.07463895,
0.1734423,
0.04128166,
-0.062113... |
Isolation of Enterobacteriaceae bacteriophage particles catalysing cell wall lipopolysaccharide degradation. | Using pairs of smooth and rough forms of Enterobacteriaceae, six smooth-specific bacteriophages were isolated from sewage and another was obtained from Dr Hedda Milch, Budapest. Upon incubation of the individual extracted (smooth) host cell wall lipopolysaccharides with the homologous purified viruses, liberation of re... | 839,201 | [
0.098433,
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0.07697166,
0.3703436,
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0.2054996,
0.3199846,
-0.028417,
0.... |
A case of functional sleep seizures. | The author presents a case of functional seizures occurring only when the patient is asleep. Discussion of the case includes the limitations of the traditional psychoanalytic explanation of conversion reactions, and focuses on reassessing conversion phenomena in terms of their communicated messages. | 839,209 | [
-0.3203239,
0.04570608,
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0.06696469,
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0.1573635,
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... |
Neuromelanin and RNA in cells of substantia nigra. | We have found that with accumulation of neuromelanin granules within cell bodies of neurones of the human substantia nigra there is a reduction in cytoplasmic RNA and a decrease in nucleolar volume. These observations imply a gradual decrease in the functional capacity of the cell such that eventually, the cell is unab... | 839,244 | [
-0.1669014,
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0.2467547,
0.1495717,
0.1162696,
0.01232738,
0.04735266,
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0.1475004,
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0.07692599,
0.05143804,
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0.5075126,
-0.08485345,
0.018756... |
Congenital abscence of the left pericardium detected by imaging of the lung: case report. | A patients with congenital absence of the left pericardium had an unusual scintillation camera image of the lung showing perfused lung between the heart and diaphragm and a priminence in the area of the pulmonary artery. This finding was not duplicated in 500 other gamma images of the lung and is probably characteristi... | 839,275 | [
-0.2265293,
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0.2870108,
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0.2218324,
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0.09807863,
0.05246837,
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0.3277669,
0.1902654,
-0.01188125... |
In vivo labeling of red blood cells with 99mTc: a new approach to blood pool visualization. | A simple and rapid procedure for in vivo labeling of red blood cells (RBC) is presented. The labeling is done with two consecutive intravenous injections, first of "cold" stannous pyrophosphate (Sn-PYP) and then of 99mTc-pertechnetate. Experimentally, a lag time of 30 min between the two injections was found to result ... | 839,281 | [
-0.04092783,
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-0.3121281,
-0.2459712,
-0.002318095,
0.6376451,
0.3671294,
0.4360509,
0.038561... |
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