title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Mortality and morbidity after esophagogastrectomy for cancer of the esophagus and cardia. | Forty-eight esophagastric resections performed for cancer of the esophagus and cardia resulted in a five-year survival rate of four per cent. An operative mortality rate of 23%, comparable to that reported by others, diminishes the value of esophagogastrectomy even for palliation. Nutritional depletion, commonly found ... | 835,905 | [
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Systemic therapy for metastatic breast cancer. | The data reviewed in this conference suggest that initial therapeutic decisions for patients with metastic breast cancer be based on the presence or absence of an estrogen receptor in the tumor. Patients with estrogen receptor in their original primary breast cancer or in a subsequent metastitic lesion are candidates f... | 835,932 | [
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Plasma glucose levels: long-term effect of diet in the Chicago Coronary Prevention Evaluation Program. | In 150 middle-aged men prone to coronary disease, long-term data based on the Chicago Coronary Prevention Evaluation Program's diet showed that there was a favorable effect on fasting glycemia level and glucose tolerance. This diet for reducing obesity and hypercholesterolemia was low in cholesterol and saturated fat a... | 835,935 | [
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Catgut and polyglycolic acid. An evaluation in the human stomach. | The breaking tensions of catgut and polyglycolic acid (Dexon) sutures placed within and then recovered from the human stomach were compared on each of 5 postoperative days. A substantial difference was evident in the performance of the two materials under these conditions. The extreme variability of catgut degeneration... | 835,985 | [
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Effects of amphotericin B on macrophages and their precursor cells. | The effect of amphotericin B (AmB) treatment on the mononuclear phagocyte system of mice was investigated. Peritoneal macrophages from mice that received AmB treatment showed a higher phagocytic and antibacterial activity than those from normal untreated mice. When the levels of macrophage precursor cells in bone marro... | 836,011 | [
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Chemically defined medium for Rothia dentocariosa. | A chemically defined medium for Rothia dentocariosa has been established. All strains tested, including the type strain, grew well in this medium. Rothia strains had a generation time of 3.5 to 4.0 h, with a yield of 62 mg (dry weight) per 100 ml after 72 h of growth in the chemically defined medium. | 836,021 | [
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Prognosis for infants weighing 1000 g or less at birth. | During the 10 years 1966-1975, 148 infants weighing less than or equal to 1000 g were admitted to the Neonatal Unit of University College Hospital. 48 (32%) survived the neonatal period. The neonatal survival rate for infants weighing less than or equal to 750 g was 8% and for infants weighing 751-1000 g, 41% 9 infants... | 836,072 | [
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Resolution of surgically induced right bundle-branch block. | In a retrospective study, the serial electrocardiograms of all patients with surgically induced right bundle-branch block (RBBB) were reviewed. None of these patients had had RBBB prior to operation. Seven patients who had RBBB from 6 to 16 days after operation showed resolution in ECGs done 3 to 8 months later. Two pa... | 836,102 | [
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Communication patterns and role structure in families of male schizophrenics a study using automated techniques. | Observers used automated methods to code who spoke to whom (Who-to-Whom) while families (mother, father, son) of 30 schizophrenics, 13 psychiatrically hospitalized nonschizophrenic controls, and 26 normal controls interacted on four tasks. From the Who-to-Whom data, measures of activity, channels of communication, and ... | 836,129 | [
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A comparison of the measurement characteristics of two circumferential penile transducers. | The measurement characteristics of two transducers which record penile circumference changes were compared. The subject wore two transducers simultaneously while viewing a section of an erotic film. Examination of the data revealed discrepancies in measurement between the two units, but these differences were shown to ... | 836,143 | [
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"Sex-role preference" as an explanatory variable in homosexual behavior. | Sex-role preference is an important neglected variable in statistically controlled studies of homosexual behavior. This variable must accompany controls for degree of psychopathology of respondents and degree of heterosexual and homosexual behavior experienced by respondents. Cross-cultural differences exist. Mexican m... | 836,144 | [
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Sexual counseling for cerebral palsied adults: case report and further suggestions. | A mildly cerebral palsied woman was seen for premarital counseling regarding sexuality and the bearing and rearing of children. A multidisciplinary approach was used; sexual counselors, a gynecologist, an orthopedist, and a geneticist met with the client for a total of 8 hr counseling time. This approach is suggested f... | 836,146 | [
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"Spoon bowl" deformity of proximal femoral bypass vein graft: a cause of late graft failure on four occasions. | We cite four examples of splaying of the proximal end of femoral bypass vein grafts accompanied by graft stenosis as a cause for late postoperative recurrent ischemic symptoms or graft failure. Though usually associated with dilation of the common femoral artery, one patient showed no arterial aneurysm. After appropria... | 836,151 | [
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EEG correlations with biochemical abnormalities in Reye syndrome. | A patient with Reye syndrome was studied throughout the course of the illness with continuous EEG monitoring, and these patterns were correlated with serial determinations of serum ammonia and short-chain fatty acid concentrations. There was high correlation between degree of EEG abnormality, clinical symptoms, and ele... | 836,179 | [
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Prognostic factors in small malignant melanomas of choroid and ciliary body. | Two hundre seventeen small malignant melanomas, each with a volume less than 1,400/cu mm, were studied to determine what factors were useful in predicting metastasis. Using a single-factor approach with 16 risk factors, we found seven that correlated well with outcome. These were cell type, pigmentation, size (largest ... | 836,203 | [
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Clinically unsuspected phacoanaphylaxis after ocular trauma. | Phacoanaphylaxis (lens-induced uveitis) is a potentially curable ocular inflammation secondary to lens truma. Recently we have seen three clinically undiagnosed enucleation specimens in our eye pathology laboratory with this entity. Our observations add an argument to the recent concept that early lens removal in cases... | 836,209 | [
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[Phlebography in fractures and dislocations of the talus (author's transl)]. | Late osteonecrosis and/or osteoarthrosis occurs frequently after dislocation and fracture dislocation of the talus. The cause seems to be a primary vascular lesion additionally to the initial damage of bone and cartilage and subsequent joint incognity. We recommended phlebography 3 to 6 months after injury for the proo... | 836,217 | [
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[The operative treatment of kyphose (author's transl)]. | Report is given on 17 patients with operative treatment of their kyphoses of various etiology. The correction itself has been carried out following diverse preoperative methods of correction using an anterior and/or dorsal approach to the spine. Altogether an average correction of 22.3 degree, that is 48 per cent could... | 836,224 | [
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Traumatic neuroma of the nose. | We report a case of a traumatic neuroma of the nose. It was an unusual site for two distinct types of tissue response to skin and soft trauma that exceeded the reparative needs of the body. In the first instance, a small cutaneous nerve was sectioned, and its inability to establish continuity distally resulted in a neu... | 836,227 | [
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Postnatal development of laryngeal reflexes in the dog. | An investigation of laryngeal reflex maturation was undertaken in the dog to identify its period of most rapid postnatal differentiation. The canine model was selected because of its laryngeal reflex similarity to that of the human being. Observations in the dog indicate maximum differentiation to occur 1 to 1 1/2 mont... | 836,240 | [
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Solitary extramedullary plasmacytoma of the larynx. | Plasmacytomas, indistinguishable histologically from plasma cell tumors arising in bone marrow, occur almost anywhere in the body-usually independently of multiple myeloma. Thus, they represent an isolated area of plasmacytic dyscrasia but occasionally can be the first evidence of multiple myeloma. From 1949 to 1974, s... | 836,244 | [
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A comparison of hearing aids with amplitude compression. | Intelligibility scores with a modified rhyme test were obtained for normally hearing subjects and subjects with sensorineural hearing impairment using several commercial hearing aids. These hearing aids differed mainly in values of time constants of compression and of harmonic distortion during overshoots. In general, ... | 836,256 | [
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Glucocorticosteroid inhibition of nonphagocytic discharge of lysosomal enzymes from human neutrophils. | Glucocorticosteroids and mineralocorticosteroids were tested for their capacity to inhibit the nonphagocytic discharge of two lysosomal enzymes--a cartilage matrix-degrading neutral protease and beta-glucuronidase--from highly purified human neutrophils. Lysosomal enzyme discharge from neutrophils adherent to nonphagoc... | 836,339 | [
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Influence of experimental stenosis on uptake of albumin by the abdominal aorta. | The influence of abdominal aortic stenosis on the uptake of the protein-binding trypan blue dye and 131I human serum albumin (HSA) has been studied. The major change was a region of high uptake proximal to the stenosis, returning to normal by the level of the renal arteries. There was reduced uptake distal to the steno... | 836,355 | [
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Lack of correlation between structural features and function of synthetic agents tested for leukocyte chemotaxis. | A number of proteins, poly-L-amino acids, oligopeptides and lipids were tested for neutrophil, eosinophil and macrophage chemotactic activity. One myoglobin preparation was active. Based on the negative findings for all other substances, primary structure, secondary structure, degree of hydrophobicity, size and charge ... | 836,432 | [
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Studies in ureteral regeneration: replacement of a large segment of ureter with an in situ pedicle graft of proximal ureter. | The phenomenon of ureteral regeneration has been of interest to clinicians, anatomists, and physiologists for many years. The object of this investigation was to study the regeneration of a long pedicle graft of ureter. Regeneration of the pedicle graft over a stent took place in 4 to 5 weeks. At sacrifice 8 to 10 mont... | 836,464 | [
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Handedness and the lateral distribution of conversion reactions. | The purpose of this investigation was to determine whether the observation of Ferenczi and Purves-Stewart that conversion reactions occur with higher frequency on the left side of the body than on the right side could be confirmed. Both right-handed and left-handed patients experienced a higher proportion of left-sided... | 836,484 | [
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Derivatives of tetrahydro-1,4-benzodiazepines as potential antihypertensive agents. | 4-Amidino derivatives and quaternary salts of tetrahydro-1,4-benzodiazepines were synthesized and evaluated for antihypertensive activity in conscious rats by the oral route. Included in this study were derivatives of 1,2,4,5,6,7-hexahydropyrrolo[3,2,1-jk][1,4]benzodiazepine and 1,2,3,4,8,9,10,11-octahydro[1,4]diazepin... | 836,492 | [
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Inhibition of solid tumors by nitrosoureas. 1. Lewis lung carcinoma. | The utility of the Lewis lung carcinoma as a secondary screen for the evaluation of nitrosoureas as anticancer agents has been assessed. The activity of this series of compounds was determined against both the early (before metastasis) and late (after metastasis) forms of the disease. Although some exceptions were note... | 836,501 | [
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Synthesis and structure-activity relationship studies of cytotoxic epoxide derivatives of 7-oxabicyclo[2.2.1]heptane. | Dimethyl exo-5,6-oxido-7-oxabicyclo[2.2.1]hept-2-ene-2,3-dicarboxylate (1) and the 1-methyl homologue 2 were shown to exhibit significant cytotoxicity in the 9KB tissue culture assay. Several analogues of 1 were prepared and it was found that removal of the epoxide, or the oxygen bridge, or the 2,3 double bond from 1 r... | 836,504 | [
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[Liver cirrhosis due to a breast neoplasm metastasis. So-called metastatic-carcinomatous cirrhosis]. | A case is presented which, 9 years after surgical removal of a scirrhous breast cancer, exhibited morphologically atypical metastasis in the liver with fibrosis and reduction of liver parenchyma, as well as typical features of cirrhosis including portal hypertension and esophageal varices. Problems posed by the differe... | 836,563 | [
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Migrating birds respond to Project Seafarer's electromagnetic field. | Radar tracking of individual migrating birds flying over a large alternating-current antenna system showed that the birds turned or changed altitude more frequently when the antenna system was operating than when it was not. These results suggest that birds sense low-intensity alternating-current electromagnetic fields... | 836,585 | [
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Hereditary hemolytic anemia with increased red cell adenosine deaminase (45- to 70-fold) and decreased adenosine triphosphate. | Hereditary hemolytic anemia, a dominantly transmitted disorder, has affected 12 family members spanning three generations. The concentration of adenosine triphosphate in the red cells was about half that of comparably reticulocyte-rich blood. Since adenosine deaminase and adenosine kinase compete for a common substrate... | 836,588 | [
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Sexual calling behavior in primitive ants. | The wingless virgin females of the ponerine ant Rhytidoponera metallica attract males by the release of a pheromone from the tergal gland, a hitherto unrecognized exocrine gland located between the last two abdominal segments. This is the first evidence for sexual chemical communication in the large and primitive subfa... | 836,590 | [
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[Cyclic esotropia (alternate day squint) (author's transl)]. | One case of the extremely rare conditioning of cyclic esotropia is reported following a short review of the literature and clinical features of this form of strabism. According to our experience the only effective treatment is operative correction on the day of the squint. It is not advisable to wait until the alternat... | 836,616 | [
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Deficient acquisition strategies: a proposed conceptual framework for analyzing severe language deficiency. | A conceptual framework was proposed for analyzing aberrant or retarded language development. Recent developments in psycholinguistics have led to a view of language acquisition as an interactive process involving external interactions between child and environment and internal interactions between cognitive holdings an... | 836,633 | [
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Note on the interpretation of interactions in comparative research. | In comparative research it is often the case that attention centers around the existence of an interaction between subject population and an experimental manipulation. Several recent investigators have discussed problems in the interpretation of such interactions. The present paper concerns one particular conceptual di... | 836,640 | [
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Human amnion metabolism. II. Incorporation of fatty acids into tissue phospholipids in vitro. | The rate of incorporation of 3H-arachidonic acid and 14C-palmitic acid into 15 term amniotic membranes was studied during incubation of tissues in an artificial amniotic fluid medium. Phospholipids were extracted from the amnions, separated by thin-layer chromatography, and both the radioactivity and the phosphorus ass... | 836,645 | [
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Glucose and oxygen metabolism in normally oxygenated and spontaneously hypoxemic fetal lambs. | Whole blood glucose and oxygen concentration were measured in chronically catheterized fetal lambs, some of whom had implanted common umbilical artery flow transducers. Ten of the fetuses were well oxygenated (femoral arterial PaO2 less than 18 torr) and 13 fetuses had evidence of chronic hypoxemia (femoral arterial Pa... | 836,649 | [
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Implantation of pure crystalline pellets of estradiol for conception control. | Estradiol pellet implantation for contraception offers another alternative in conception control. The occurrence of only two pregnancies in 1,668 cycles (Pearl index: 1,42) reflects its efficacy. The advantages over oral contraceptives are: (1) absence of gastrointestinal symptoms, (2) minimal untoward effects, (3) no ... | 836,652 | [
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... |
HLA-B8 and dermatitis herpetiformis in patients with IgA deposits in skin. | The association between antigens of the HLA system and dermatitis herpetiformis (DH) using in vivo-bound IgA as an added criteria for diagnosis is reexamined. Twenty-eight of 33 (85%) immunologically proven patients with DH were HLA-B8 positive, whereas only 17 of 92 (18%) controls were HLA-B8 positive. | 836,691 | [
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Cutaneous manifestations of idiopathic hemochromatosis. Study of 100 cases. | Skin manifestations of idiopathic hemochromatosis (IH) are presented in 100 cases with emphasis on the previously unrecognized high frequency of ichthyosis-like states and koilonychia. In 50 cases with treated and nontreated groups, histological siderosis and clinical skin pigmentation were found to decrease postphlebo... | 836,692 | [
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[Epidemiology of skin diseases in 10,000 patients of pediatric age]. | Ten thousand new patients were seen between January 1971 and January 1975 at the Department of Pediatric Dermatology, "Hospital del Niño IMAN" in Mexico City. The patients were between 0 and 18 years old. They represented 10.4% of the entire pediatric population attending the general out-patient clinic of the hospital.... | 836,712 | [
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Mechanism for the incorporation of S-(1,2,3,4-tetrahydro-2-hydroxy-1-naphthyl)-L-cysteine into protein. | Evidence is presented which indicates that S-(1,2,3,4-tetrahydro-2-hydroxy-1-naphthyl)-L-cysteine (THN-cysteine), formed by the reaction of 1,2-epoxy-THN with cysteine, can be incorporated into protein; The position of incorporation of THN-cysteine into protein would depend on whether the epoxide of THN reacts with cys... | 836,759 | [
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Cervical cancer: Age at registration and age at death. | The 5-year survival of women with localized (early-stage) cervical cancer is much higher than for women with non-localized (late-stage) cancer, but women with localized cancer tend also to be younger than those with advanced cancer. A new method of presenting the long-term survival is suggested, and the registrations o... | 836,761 | [
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... |
Bovine serum albumin and aqueous guanidine hydrochloride solutions. Preferential and absolute interactions and comparison with other systems. | The partial specific volume, upsilon20, of bovine serum albumin at 25 degrees C was found to be 0.728 +/- 0.001 ml/g in solutions of guanidine hydrochloride (GuHC1), 0.01 M dithioerythritol (DTE), independent of GuHC1 concentration (3-6 M). The volume decrease upon denaturation is about 400 ml/mol (upsilon20 in water a... | 836,784 | [
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Effects of detergents on the properties of 4-hydroxybenzoate. Polyprenyl transferase and the specificity of the polyprenyl pyrophosphate synthetic system in mitochondria. | The properties of 4-hydroxybenzoate:polyprenyl transferase and the system synthesizing polyprenyl pyrophosphate have been studied in mitochondria from rat and guinea pig livers. With solanesyl pyrophosphate and 4-hydroxybenzoate as substrates the formation of 3-nonaprenyl-4-hydroxybenzoate was linear with time, concent... | 836,803 | [
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Evidence for the preferential interaction of glycophorin with negatively charged phospholipids. | Glycophorin, extracted from the erythrocyte membrane after treatment with lithium-diiodo-salicylate, still contains a significant amount of phospholipid, consisting predominantly of phosphatidylserine. Methods are described which lead to a full delipidation of the protein. After treatment with neuraminidase, delipidate... | 836,822 | [
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gamma-Aminobutyric acid-stimulated chloride permeability in crayfish muscle. | gamma-Aminobutyric acid selectively increased Cl- permeability in isolated strips of crayfish abdominal muscle. Muscle fibers incubated in Van Harrevald's solution at room temperature took up 36Cl- to the extent of 700 ml/kg wet weight with a halftime of 2.5 min. During 15-S incubations, the control 36Cl- uptake space ... | 836,825 | [
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Energy-dependent uptake of calcium by the yeast Schizosaccharomyces pombe. | 1. In resting cells of the fission yeast Schizosaccharomyces pombe, the uptake of calcium is stimulated by the addition of 90 mM glucose in the presence as in the absence of respiration and inhibited by Antimycin A in the absence of exogenous carbon source. This uptake therefore requires fermentative or respiratory met... | 836,827 | [
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The effects of hypothyroidism and fasting on electrogenic amino acid transfer: possible evidence for multiple neutral amino acid carrier systems in rat jejunum. | The jejunal mechanisms for the electrogenic transfer of four neutral amino acids (alanine, leucine, methionine, valine) and for sarcosine were characterised by an electrical method in vitro. The values for apparent Km obtained electrically agree well with those assessed by conventional chemical techniques. Hypothyroidi... | 836,828 | [
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The effect of S-adenosylhomocysteine on DNA methylation in isolated rat liver nuclei. | DNA methylation was studied in vitro using whole nuclei from regenerating rat liver. Methyl incorporation from S-adenosyl-[Me-3H]methionine in nuclei from regenerating liver was four times higher than that of normal liver. The effect of S-adenosylhomocysteine on DNA methylation was examined, and it was found at equal m... | 836,843 | [
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Radioimmunoassay for canine creatine kinase isoenzymes. | Antibodies specific for the B and M subunits of creatine kinase (ATP: creatine N-phosphotransferase, EC 2.7.3.2) isoenzymes were obtained by immunization of rabbits with canine BB and MM creatine kinase. A radioimmunoassay capable of measuring picomolar amounts of creatine kinase isoenzymes has been developed which mea... | 836,852 | [
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Raman spectra of some saturated, unsaturated and deuterated C18 fatty acids in the HCH-deformation and CH-stretching regions. | We have analyzed the Raman spectra of stearic acid and two deuterated derivatives thereof, 2,2-dideutero stearic acid and 18,18,18-trideutero stearic acid, as well as of four unsaturated, C18 acids, (cis,-9; cis, cis-9,12, cis, cis, cis-9,12,15; and trans, trans-9,12) in their solid and liquid states. The different spe... | 836,854 | [
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... |
Mitochondrial biogenesis in cultured mammalian cells. III. Synthesis of mitochondrial phospholipids by subcellular fractions isolated from normal and chloramphenicol-treated BHK-21 cells. | The capacity of subcellular fractions isolated from chloramphenicol-treated BHK-21 cells to synthesize various mitochondrial phospholipids in vitro and examined. Both mitochondria and microsomes showed the capacity to acylate sn-glycerol 3-phosphate and dihydroxyacetone phosphate to lysophosphatidic acid and acyldihydr... | 836,855 | [
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0.0184599,
... |
Tyrosyl fluorescence in hemocyanin from the scorpion Leirus quinquestriatus. | The fluorescence properties of hemocyanin from the scorpion Leirus quinquestriatus were studied. Emission and excitation spectra were determined for protein in both its oxygenated and deoxygenated forms. Oxygenation was found to bring about a large blue shift in the position of the fluorescence maximum, in addition to ... | 836,875 | [
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Purification of human immunoglobulin M by affinity chromatography on protamine-Sepharose. | Human IgM has been isolated from plasma by a simple procedure in high yield. The first step was adsorption to protamine-Sepharose and elution by increasing the ionic strength with NaCl. This was followed by two gel filtration steps resulting in a 98% pure IgM in about 30% yield. A somewhat modified procedure could also... | 836,879 | [
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Reinvestigation of the primary structures of red deer and roe deer pancreatic ribonuclease and proline sites in mammalian ribonucleases. | The sequences of amino acid residues 15-23 of red deer (Cervus elaphus) and roe deer (Capreolus capreolus) pancreatic ribonuclease and the identity of residue 99 in roe deer ribonuclease are corrected. Earlier results are explained by the cleavage of an Asp-Pro bond in both enzymes during the treatment with CNBr in 70%... | 836,889 | [
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The isolation and identification of 2-methyl-2,4-thiazolidine dicarboxylate as a by-product in the conversion of cysteine to glucose in the perfused rat liver. | Cysteine is one of the more toxic amino acids, however the toxic agent associated with cysteine toxicity has not been identified. Recently it was shown that 2-methyl-2,4-thiazolidine dicarboxylate (MTD) was formed fromcy steine by rat liver and would be toxic to the rat. This suggested that MTD formed by the rat liver ... | 836,890 | [
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Application of polarography to the study of chemical radiosensitization of DNA components. | The half-wave reduction potentials of a range of nitroheterocyclic compounds were measured polarographically and compared with their radiosensitizing abilities in a simple radiation biochemical assay for damage to 5'-GMP. The chemical enhancement ratio for sensitization of inorganic phosphate release from irradiated 5'... | 836,895 | [
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Plasminogen activator from human embryonic kidney cell cultures. Evidence for a proactivator. | The nature of the trypsin-activatable plasminogen activator produced by kidney cell cultures (Bernik, M.B (1973), J. Clin. Invest. 52, 823-834) was investigated using human embryonic kidney (HEK) cell cultures in serum-free medium. Plaminogen activator activity ratios (trypsin-activated/ untreated controls) in HEK cell... | 836,903 | [
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A tryptic digestion fragment of nerve growth factor with nerve growth promoting activity. | A peptide, isolated from the acid-insoluble portion of a tryptic digest of cyanogen bromide cleaved nerve growth factor, favors life maintenance of sensory target cells and promotes rapid neurite outgrowth from 7-day-old chick embryo sensory ganglia. The fragment has been identified as a 30 amino acid peptide consistin... | 836,904 | [
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Studies on the receptors to 5alpha-androst-16-en-3-one and 5alpha-androst-16-en-3alpha-ol in sow nasal mucosa. | The presence of receptors to the "boar taint" pheromones 5alpha-androst-16-en-3-one and 5alpha-androst-16-en-3alpha-ol has been demonstrated in sow olfactory mucosa. Binding studies indicated that a sufficiently low concentration of olfactory tissue homogenate exhibited saturation of binding of 5alpha-androst-16-en-3-o... | 836,907 | [
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Purification of rat intestinal receptor for intrinsic factor-vitamin B-12 complex by affinity chromatography. | Rat intrinsic factor was bound to vitamin B-12-Sepharose to produce intrinsic factor-vitamin B-12-Sepharose. Intestinal receptor for intrinsic factor-vitamin B-12 complex was purified from rat ileal extract by affinity chromatography using the intrinsic factor-vitamin B-12-Sepharose as an affinity adsorbent with recove... | 836,908 | [
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Migration of transfused granulocytes in leukopenic dogs. | Although granulocyte transfusion therapy has been shown to be effective in infected granulocytopenic animals and humans, the relative effectiveness of granulocytes (PMN) harvested by continuous flow centrifugation (CFC) or by continuous flow filtration leukapheresis (FL) remains uncertain. Studies in vitro of morpholog... | 836,957 | [
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Uptake and metabolism of noradrenaline by the mesenteric arteries of the dog. | Uptake and metabolism of tritiated noradrenaline by the mesenteric arteries of the dog and concomitant behaviour changes in endogenous noradrenaline are described. Posterior mesenteric artery strips were incubated for 30 min in Krebs solution containing (-)-7-3H-noradrenaline (1,084 muM); suitable pretreatments and/or ... | 836,961 | [
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A comparison of the effects of sodium thiocyanate and dantrolene sodium on a mammalian isolated skeletal muscle. | 1 A combination of electrical and pharmacological stimulation has been used to compare the effects of sodium thiocyanate and dantrolene sodium on the excitation-contraction coupling (ECC) mechanism of the mouse soleus muscle. 2 Thiocyanate prolonged the 'active state' after electrical stimulation and increased the resp... | 836,993 | [
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Sleep induced by drugs injected into the inferior horn of the lateral cerebral ventricle in dogs. | 1 In unanaesthetized dogs, cholinomimetic drugs and their antagonists were injected into the inferior horn of the left lateral cerebral ventricle. Injection volumes of 5 mul were used to limit spread of the drugs beyond the inferior horn. The effects on EEG and behaviour were recorded and compared with the effects of t... | 837,011 | [
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The clinical diagnostic value of the carcinoembryonic antigen (CEA) in haematuria. | Plasma and urinary CEA levels in patients presenting with haematuria have been studied to assess whether they facilitate the differentiation between benign and malignant urothelial conditions. Plasma CEA is of no diagnostic value although, if raised, it may suggest an invasive tumour. Urinary CEA levels are only of val... | 837,050 | [
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Can drug compliance in the elderly be improved? | Three instruction schemes for self-medication in older patients were designed and compared to see whether they improved drug compliance. Forty-six patients in two rehabilitation units were divided into three different groups. Each group was instructed verbally on the nature and amount of their medication. One group was... | 837,099 | [
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Clinical trials of the treatment of breast cancer in Britain and Ireland. Report by co-ordinating committee. | Thirteen trials of systemic chemotherapy in early breast cancer were identified and protocols obtained. The differences in the latter prevented a true comparison of the results. In setting up any trial it is important to define the primary objectives and to include a statistician from the start. Only truly random alloc... | 837,100 | [
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Rapid dendritic atrophy following deafferentation: an EM morphometric analysis. | The nucleus laminaris (NL), a third-order brain stem auditory nucleus in birds, receives afferents to its dorsal dendrites from the ipsilateral nucleus magnocellularis (NM), while the ventral dendrites of NL neurons are innervated by axons from the contralateral NM via the crossed dorsal cochlear tract (CTrX). The CTrx... | 837,214 | [
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Ontogeny of lipid bodies in the endoplasmic reticulum of Fusarium sulphureum. | The ontogeny of lipid bodies during the differentiation of conidial cells to chlamydospores in Fusarium sulphureum (F. sambucinum f. 6) is described. The lipid bodies are first seen as electron-transparent areas within dilated cisternae of the endoplasmic reticulum (ER). One or more such cisternae may be formed within ... | 837,253 | [
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Economic status and survival of cancer patients. | The relation of economic status to survival was studied for 39 kinds of cancer representing all types for which 60 or more indigent patients were seen in University of Iowa Hospital for primary care during the years 1940-1969. For every type the indigent patients had poorer survival than non-indigent patients. Quality ... | 837,332 | [
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Intravenous Corynebacterium parvum: an adjunct to chemotherapy for resistant advanced ovarian cancer. | This is a prelimianry report of an effort to treat women with advanced (Stage III and IV) ovarian cancer who had progressive disease in spite of previous surgery, chemotherapy and/or radiation by a program of reductive surgery, intensive immune stimulation and combination chemotherapy. An initial laparotomy was done wh... | 837,334 | [
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Inhibitory effects of selenium on 1,2-dimethylhydrazine and methylazoxymethanol acetate induction of colon tumors. | Sprague-Dawley rats were injected weekly with either 1,2-dimethylhydrazine (DMH) or methylazoxymethanol acetate (MAM). Addition of 4 ppm selenium (sodium selenite) in the drinking water reduced the number of rats developing DMH-induced colon tumors from 13 to 6 groups of 15 each. The total number of tumors observed in ... | 837,360 | [
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Macromolecular binding of glucocorticoids in human mammary carcinoma. | The presence of glucocorticoid receptors was examined in 100 primary and 22 metastatic human breast cancer lesions. Aliquots of cytosol were incubated in vitro with tritiated cortisol and dexamethasone with and without competing steroids. Two different types of glucocorticoid receptors were detected. One is similar to ... | 837,365 | [
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A clinical evaluation of serum C3DP levels in individuals with malignant diseases. | A human serum DNA-binding protein (C3DP) derived from complement component C3 has been found in elevated concentrations in the sera of individuals with malignant diseases. An assay system has been devised which reveals quantitative values of serum C3DP levels. Results obtained using this system indicate that normal hum... | 837,370 | [
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The phosphorylation of histones in rat liver undergoing malignant transformation. | The incorporation of inorganic phosphate into H1-histones of rat liver was stimulated after the repeated s.c. administration of diethylnitrosamine. This stimulation was observed as early as after the fifth daily injection of the carcinogen and amounts to approximately 3 times the control value on the 60th day of the ex... | 837,377 | [
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In vitro and in vivo cytotoxicity of adriamycin and daunomycin for murine macrophages. | In virto exposure of murine lymphoma cells to adriamycin and daunomycin (DM) for 24 hr resulted in comparable cytotoxicity as assessed by viable cell counts and inhibition of DNA synthesis. The spontaneous DNA synthesis of spleen lymphocytes in vitro was also equally affected by the two agents. However, when the in vit... | 837,378 | [
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The villous stroma of the human placenta. I. The ultrastructure of fixed connective tissue cells. | In human placental villi the connective tissue is constructed by mesenchymal cells, small and large reticulum cells and fibroblasts. During early pregnancy mesenchymal cells dominate; starting with the third month of gestation the reticulum cells are in the majority within the terminal villi, the fibroblasts within the... | 837,398 | [
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... |
Freeze-fracturing of the auditory basilar papilla in the lizard Calotes versicolor. | Membrane-associated structures were studied in the cells of the basilar papilla, the hearing organ of a lizard, Calotes versicolor, by means of freeze-fracture. Zonulae occludents of an intermediate to tight type were found to join the apical membranes of sensory and supporting cells. Gap junctions were frequently obse... | 837,417 | [
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Exocrine pancreas under experimental conditions. III. Membrane and cell junctions in isolated acinar cells. | The ultrastructure of the cell membrane and intercellular junctions was studied after isolation of exocrine pancreatic cells by tryptic digestion and mechanical treatment. The number and distribution of membrane associated particles does not change significantly when acinar cells in situ are compared to those after the... | 837,418 | [
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0.1608967,
0.2534272,
0.3771009,
0.247721,
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-0.2781058,
-0.1617647,
-0.3560093,
-0.2697889,
-0.004169442,
-0.3384833,
-0.2141614,
0.2622173,
-0.006195827,
0.304057,
0.04892462,
-0.04995... |
Measurements of noradrenaline fluorescence in axons of chick embryo sympathetic ganglia grown in three day culture. | Chicken embryo sympathetic ganglion fragments, grown in culture for three days, were incubated for short periods in appropriate experimental and control media to provide information on axonal uptake of exogenous noradrenaline in the presence and absence of the uptake-blocking drugs, protriptyline and phenoxybenzamine. ... | 837,425 | [
-0.01938375,
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0.339208,
0.5001136,
0.2141608,
0.09552148,... |
External counterpulsation: coronary hemodynamics and use in treatment of patients with stable angina pectoris. | External pressure counterpulsation (ECP) has been reported to improve the clinical status of patients with angina pectoris. To document the mechanisms for such an improvement left ventricular oxygen consumption and lactate metabolism, coronary sinus blood flow, and cardiac index were studied in 10 patients with angina ... | 837,432 | [
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0.08934274,
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Single left pulmonary vein with normal pulmonary venous drainage: association with partial anomalous pulmonary venous return. | An unusual case of a single left pulmonary vein draining the left lung and joining the left atrium without venous obstruction is reported. This anomaly occurred in association with partial anomalous pulmonary venous return from the upper lobe of the right lung to the superior vena cava. A similar case has been previous... | 837,434 | [
-0.0413832,
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0.2862656,
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0.4011299,
0.02735591,
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... |
Visualization and mapping of late nuclear adenovirus RNA. | Nuclei of KB cells harvested at late stages of productive infection with adenovirus type 2 (Ad2) harbor RNA molecules which measure up to 13 mum in length, as determined by electron microscopy of denatured RNA. While some of the molecules display features of secondary structure that are characteristic for precursor rRN... | 837,447 | [
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0.02005422,
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0.08155344,
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0.81194,
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-0.167472... |
Clonal variation in colony morphology and growth of CHO cells cultured on agar. | Single Chinese hamster ovary (CHO) cells plated on agar form macroscopic colonies with high efficiency. Colonies produced by cells from the uncloned cell line increase in diameter continuously for 10-12 days after plating to form mounds of cells about 1 mm in diameter. With further incubation, some of these colonies do... | 837,451 | [
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0.3703268,
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0.0... |
Heavy metal complexation in polluted molluscs. I. Limpets (Patella vulgata and Patella intermedia). | The accumulation of cadmium, zinc and copper by the marine gastropod molluscs Patella vulgata and Patella intermedia has been studied by gel permeation chromatography of water-soluble extracts of environmentally contaminated shellfish. A major proportion of the water-soluble cadmium and copper in these molluscs is asso... | 837,462 | [
-0.056695,
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0.1244908,
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0.2943461,
0.2464076,
0.02846501,
-0.04800046,
0... |
Action of 1,10-phenanthroline transition metal chelates on P388 mouse lymphocyte leukaemic cells. | (1)Fully coordinated 1,10-phenanthroline and 2,2'-bipyridine chelates of Ru(II) are lethal in vitro to cultured and ascites P388 mouse lymphocytic leukaemic cells; 1,10-phenanthroline chelates are generally more potent than corresponding 2,2'-bipyridine compounds, and mixed-ligand (acetylacetonato) monovalent chelates ... | 837,467 | [
-0.1046586,
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0.1475724,
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0.4149984,
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0.0845689,
0.03077835,
0.2... |
Intrarenal renin-angiotensin-sodium interdependent mechanism controlling postclamp renal artery pressure and renin release in the conscious dog with chronic one-kidney Goldblatt hypertension. | We studied postclamp renal artery pressure and renin release in eight conscious dogs with one-kidney Goldblatt hypertension. On normal sodium intake, intrarenal blockade of angiotensin II with Sar1-Ala8-angiotension II (P-113, saralasin acetate) markedly decreased postclamp renal artery pressure and increased renin rel... | 837,470 | [
-0.2206713,
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0.06638741,
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0.2191614,
-0.2482191,
... |
Reproducibility of thallium-201 myocardial imaging. | Seventy-six thallium-201 myocardial perfusion studies were performed on twenty-five patients to assess their reproducibility and the effect ofvarying the level of exercise on the results of imaging. Each patient had a thallium-201 study at rest. Fourteen patients had studies on two occasions at maximum exercise, and tw... | 837,485 | [
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0.3337825,
0.05318935,
0.1226997,
0.2488238,
0.... |
Hemodynamic effects of dobutamine in patients following open heart surgery. | Dobutamine, a new synthetic inotropic agent, was administered by intravenous infusion to 22 patients following open heart surgery. The dosage of dobutamine started from 2 mug/kg/min and was increased stepwise to 4, 6, and 8 mug/kg/min. Cardiac index increased from 2.54 +/- 0.13 to 3.11 +/- 0.19 and 3.50 +/- 0.22 L/min/... | 837,487 | [
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0.2676348,
0.1164206,
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0.3225089,
0.05782671,
-0.1415515,... |
Asymptomatic left ventricular aneurysm: a sequela of blunt chest trauma. | A routine chest X-ray taken four months after blunt chest trauma revealed a left ventricular aneurysm in a totally asymptomatic patient. At surgery a thin-walled, clot-filled aneurysm was successfully removed. This case demonstrates the need for careful follow-up of all patients sustaining blunt chest trauma even thoug... | 837,491 | [
-0.2308796,
0.5179597,
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0.2735387,
0.1619014,
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0.4386987,
0.1283553,
-0.03474857,
0.327... |
Coronary arterial origin in persistent truncus arteriosus. | Specimens of heart from 30 subjects with persistent truncus arteriosus were studied for the nature and sites of coronary arterial origin. These factors were related to the sinuses of the truncus valve. Bicuspid truncal valve was observed in six cases (20%) and tricuspid in 21 cases (70%). Single coronary artery was obs... | 837,493 | [
-0.02814548,
0.09336362,
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0.1340238,
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0.2200249,
0.2240345,
-0.1995207,
... |
Myocardial metabolism in cyanotic congenital heart disease studied by arteriovenous differences of lactate, phosphate, and potassium at rest and during atrial pacing. | To study myocardial metabolism in chronic hypoxia due to cyanotic congenital heart disease, coronary arteriovenous differences of lactate (L), pyruvate (P), inorganic phosphate (Pi) and potassium (K) were measured in 14 cyanotic patients and seven controls, at rest and during atrial pacing. At rest, there was no differ... | 837,511 | [
-0.3128618,
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0.05595315,
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0.1002217,
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0.2960432,
0.08771017,
0.09196574,
0.1532779,
-0.2237023... |
Effect of structure on the excretion of steroidal acids in human urine and their potential colorimetric assay as 17-oxogenic steroids. | Following the oral administration of tritiated coricosterone, cortisol, deoxycorticosterone and progesterone to human subjects, 14.9%, 12.8%, 3.4% and 2.1% of the dose was recovered in the acidic metabolite fraction of 48 h urines after conventional hydrolysis and solvent partition. Neutral and acidic 17-oxogenic stero... | 837,525 | [
0.04487375,
0.2727135,
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0.1766602,
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0.07261905,
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0.1172724,
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0.1393123,
0.3036623,
0.3411112,
0.4342733,
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0.... |
Separation of serum creatine kinase isoenzymes by ion-exchange column chromatography. | We describe a practical, technically convenient DEAE-Sephadex chromatographic column and a three-fraction salt-gradient elution procedure, with which serum creatine kinase activity is rapidly and quantitatively separated into the isoenzyme components with excellent analytical recovery of the total activity applied. The... | 837,538 | [
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0.317149,
0.3400013,
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... |
Cortisol production rate determined by radio gas-chromatography. | We describe a ratio gas-chromatographic method for determination of cortisol production rate by measuring the isotope dilution of urinary cortisol metabolites. The method was calibrated by analyzing [3H]tetrahydrocortisol and [3H]tetrahydrocortisone of known specific activities. Results are reasonably well reproducible... | 837,540 | [
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0.268616,
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0.3038989,
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0.3198484,
0.3527383,
0.01361611,
-0.08543481,
-0.... |
Biological variability in aspartate aminotransferase activity in serum of healthy persons, and effect of in vitro supplemantation with pyridoxal 5-phosphate. | Aspartate aminotransferase (EC 2.6.1.1) activities in sera from nine healthy individuals were monitored during two weeks, both with and without first supplementing the serum with pyridoxal phosphate. Pyridoxal phosphate supplementation caused a mean increase of 39% (range, 33-55%) in measured activity. The biological v... | 837,543 | [
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0.04099983,
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0.4955906,
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0.4628655,
0.0217374,... |
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