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Hyperthermia in the treatment of cancer.
There is now considerable evidence that heat can be used to destroy tumours. The metabolism of many types of cancer cell is selectively damaged at temperatures of 42-43 degrees C, and deficient tumour blood-flow at raised temperature represents a further exploitable Achilles heel. A striking feature of tumour heating i...
84,218
[ -0.152566, 0.009366257, -0.3949741, -0.01093759, 0.1305435, -0.07341313, -0.1898459, 0.05598841, 0.4310609, 0.04271148, 0.1072966, -0.4163148, 0.1273221, -0.170406, -0.5242935, -0.1588922, 0.04863326, -0.2037339, -0.2619099, 0.446913, 0.4541221, -0.02625838, -0.3109357, ...
Isolation of alpha-1 fetoprotein.
A suitable method of the isolation of alpha-1 fetoprotein for the needs of enzyme immunoassay of this oncofetal antigen is described. By combining isoelectric focusing and "indirect" affinity chromatography the preparation of alpha-1 fetoprotein was obtained that was not contaminated with IgG, contrary to the isolation...
84,345
[ -0.4212978, -0.1500037, -0.3814285, 0.003829226, 0.03037615, -0.3877687, -0.2996982, 0.0492868, -0.1117882, 0.124433, 0.1412809, 0.1683124, 0.303642, -0.361225, -0.1267017, -0.07390282, -0.5456361, -0.09084431, 0.06778918, 0.0540802, 0.474477, -0.1215434, -0.2874286, 0....
Clinical evaluation of radio-labelled bleomycin for tumor detection.
Investigations with bleomycin labelled with radionuclides other than 57Co in patients with cancer and in tumor-bearing animals are described. In patients 57Co-bleo appears to be a better tumor-seeking radiopharmaceutical than 111In-bleo, 99mTc-bleo or 197Hg-bleo. This can be explained by a higher stability in vivo and ...
84,374
[ -0.04482057, 0.1369461, -0.599945, -0.4696488, -0.3587901, 0.0330257, -0.3410891, -0.01081751, -0.2197437, -0.2843125, -0.04792182, 0.2079566, 0.170485, -0.1413926, -0.5074309, -0.205227, -0.07271452, 0.2834886, 0.1592164, 0.4098012, 0.5662193, 0.434132, 0.2384786, 0.21...
Interaction of phosphatidylserine with mast cells.
Phosphatidylserine (PtdSer) potentiates histamine secretion from mast cells exposed to concanavalin A and Ca2+. In order to identify the form of PtdSer that is responsible for its effect on mast cell secretion, PtdSer containing a tritium-labeled serine moiety (3H-PtdSer) was synthesized from egg yolk phosphatidylcholi...
84,384
[ -0.1280649, -0.1803903, -0.3017791, -0.06539945, 0.239781, -0.001904418, -0.1762396, 0.1116443, 0.1559518, 0.1943686, -0.193205, 0.3156226, -0.2831306, 0.04445858, -0.4147475, 0.005625483, -0.4490693, -0.04339455, -0.2202457, 0.2648804, 0.2581966, 0.1723279, 0.1988878, ...
[Transurethral electroresection--an alternative to the indwelling catheter of old patients with prostatic hypertrophy].
The people become elder in this time, everywhere. The number of patients with adenoma of the prostate is increasing. Most of them have other diseases, too. A retrospective study (2646 cases in 8 years, exactly specially analysed 469 cases from 1975/1976) was done, comparing the results of TUR and open surgery. Well kno...
84,444
[ -0.01747344, -0.1308793, -0.2825279, -0.08897959, -0.2499524, -0.4741387, -0.3047903, 0.1255966, -0.2454782, 0.002171236, 0.1662867, 0.03490429, -0.212618, -0.4617786, -0.455686, -0.04420485, -0.4996893, 0.2944789, 0.3543808, -0.1678498, 0.2907026, 0.03360644, -0.113792, ...
[Determination of human IgI allotypes by using a set of stable erythrocyte antigenic diagnostica of varying specificity].
Technology of preparing a set of stable antigenic diagnostic agents of commercial type for determination of genetic determinants of human IgG and antibodies to them in the human blood sera and in the animal hyperimmune sera was worked out. Antisera against some human IgG allotypes were prepared. The frequency of detect...
84,455
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Serum alkaline phosphatase activity in acrodermatitis enteropathica: an index of the serum zinc level.
A significant positive correlation between serum zinc and serum alkaline phosphatase levels was demonstrated in four patients suffering from acrodermatitis enterophathica for which they received oral zinc sulphate therapy. In one of the male patients a significant inverse relation between serum zinc and serum copper wa...
84,482
[ -0.2159954, -0.3243789, -0.06710881, -0.1268394, -0.2682918, -0.09137279, -0.5023872, 0.09669889, -0.1375662, -0.06412005, 0.2530343, -0.03017513, 0.1650027, -0.01025949, -0.4213645, 0.1256903, -0.1480091, -0.06859571, -0.3732606, 0.004914229, 0.1809582, 0.1951223, -0.162...
Penetration of 65Zn through the skin of rats.
A study has been made of the penetration of 65Zn from various zinc chloride solutions, from a zinc oxide suspension and from a zinc tape containing zinc oxide through the intact skin of rats. 65Zn rapidly appeared in the blood and other tissues. The maximum 65Zn activity in serum occurred within or around the first hou...
84,485
[ -0.02450079, -0.09110077, -0.2125512, -0.28501, -0.07381652, -0.1351398, -0.4188275, -0.03037299, -0.06548696, -0.05529378, 0.1016332, 0.00383553, 0.009340464, 0.2070638, -0.1504296, -0.1616572, -0.04915796, 0.01871217, -0.03478968, 0.1120185, 0.3220486, 0.3013131, 0.1208...
Hormonal analysis and delayed hypersensitivity reactions in identical twins with severe acne.
Identical twins aged 17 and another pair aged 21 are described. One pair had febrile ulcerative conglobate acne; the other, cystic acne. The location of acne, the type of the lesions and the course of the disease were very similar in the two twins of each pair. The testosterone levels of the 17-year-old pair varied and...
84,495
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Abnormal glucose tolerance associated with lichen planus.
A study was made of 52 patients with lichen planus. Abnormal oral glucose tolerance was found in 19 (36%), including 5 with overt diabetes. The criteria for abnormality were based on an age-related score method. A family history of diabetes was found to be present in 14 (26%). The most common abnormality observed in th...
84,497
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Multiple glomus tumours: a report of a family in Denmark.
In a family affected by multiple glomus tumours, one of the members had approximately 500 tumours spread over the entire skin. The histopathological similarity to cavernous haemangioma is emphasized. We consider that multiple glomus tumour is a more common skin disease than is assumed today.
84,502
[ -0.1649276, 0.0482186, -0.2297633, -0.3329293, 0.1211374, -0.1671229, -0.1891512, -0.1965199, -0.01744233, 0.1409403, 0.3483584, 0.1158284, 0.121729, -0.2783646, -0.2425445, -0.05930566, -0.06812701, 0.2066907, 0.183812, 0.01709227, 0.2881728, 0.2962911, 0.07964559, 0.2...
The occurrence of homoreactant factors and the examination of their influence on IgG synthesis.
Authors studied the occurrence of antibodies agglutinating IgG determinants with Rh positive red blood cells covered with IgG molecules of anti-Rh(D) activity treated with papain, pepsin, and trypsin. The occurrence of Fab antibodies was studied in the sera of newborn and of 1-6 years old healthy children, further on q...
84,527
[ 0.1434468, -0.2000528, -0.268488, 0.2305856, 0.1738017, -0.1613486, -0.08192063, 0.1469462, 0.008958495, 0.3506933, 0.2554198, 0.241075, -0.08657188, 0.1312322, -0.3030367, -0.05581531, -0.3740192, -0.00874023, -0.07103432, 0.3734941, 0.3614442, 0.1413079, -0.2326256, -...
Prenatal methylmercury poisoning. Clinical observations over five years.
Thirty-two infants prenatally exposed to methylmercury and their mothers were examined over a five-year period after the Iraqi methylmercury epidemic. Severity of poisoning in mothers was related to the peak mercury concentration in their hair and in the infants to the maximum concentration in maternal hair during preg...
84,530
[ -0.2760977, -0.1824348, 0.09492474, -0.226574, -0.1223907, -0.04162265, -0.5278267, -0.1082921, 0.1006628, 0.1080553, 0.2088204, 0.125591, -0.2485967, 0.2606869, 0.4148695, -0.0637287, -0.5190147, 0.4529811, -0.2136936, 0.04521393, 0.2189251, 0.1924094, 0.3418062, 0.058...
Protected environment-prophylactic antibiotic program for malignant lymphoma. Randomized trial during chemotherapy to induce remission.
Fifty-eight patients with malignant lymphoma were randomly allocated to receive three courses of chemotherapy to induce remission with CHOP-Bleo on the protected environment-prophylactic antibiotic (PEPA) program (30 patients) or as controls (28 patients). The complete remission rate for all patients was 74 per cent, f...
84,532
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Interpreting elevated amniotic fluid alpha-fetoprotein levels in clinical practice: use of the predictive value positive concept.
The amniotic fluid alpha-fetoprotein assay (AF-AFP) is the single most valuable method of detecting anencephaly--spina bifida (ASB) in utero. A raised AF-AFP, however, is a more reliable indicator of a fetus with ASB in the pregnancy at high risk for ASB. Most women undergoing fetal chromosomal analysis are at low risk...
84,534
[ -0.1076243, -0.2436104, -0.08042589, -0.1681455, 0.6491323, -0.07670218, -0.3570046, -0.2314295, 0.306968, -0.2011169, 0.2203477, 0.5167962, 0.1038792, -0.08719291, -0.006183867, -0.004702713, -0.6854485, 0.1506086, 0.04267116, -0.1686117, 0.2982178, -0.0109169, -0.149724...
Neuromuscular blocking agents and spontaneous sympathetic activity.
The action of neuromuscular blocking agents on the spontaneous sympathetic activity has been quantitated. "On line" spectrum analysis has been applied to the action potential of pre- and post ganglionic nerves of the coeliac plexus. The activity, the frequency spectrum and their changes after the injection of clinical ...
84,556
[ 0.08806357, -0.2881613, -0.5104589, -0.2972803, -0.07393865, 0.001190295, -0.1623046, -0.2475041, -0.1458399, -0.03148206, 0.009175698, -0.1310109, 0.1846229, 0.004072004, -0.1381423, -0.1750143, -0.9433687, 0.116504, -0.0407553, 0.2642684, 0.2465271, 0.09129708, 0.342127...
[Characteristics of myelin basic protein from dog spinal cord].
Some characteristics of the myelin basic protein from dog spinal cord were studied. The basic protein has a molecular weight of 18,000; the isoelectric point is 9.5. The amino acid composition of the protein was determined. Electrophoresis in 15% polyacrylamide gel revealed the heterogeneity of the basic protein. The E...
84,691
[ 0.0627966, 0.130838, 0.1365973, -0.02202328, -0.06555739, -0.406541, -0.1289831, -0.154631, -0.03995579, -0.06432439, -0.1054803, 0.1056028, 0.2497496, -0.01187679, -0.1089516, -0.03841808, -0.4813353, 0.3002653, 0.162159, -0.1298752, -0.1337807, 0.1977958, 0.1337554, -...
[Inhibition of compound 48--80 induced histamine liberation from mast cells by triton X-100].
Triton X-100 at concentrations preceding those which liberated histamine, produced dose-dependent inhibition of compound 48/80-induced histamine release from rat mast cells. Triton X-100 (0.00002 1/1) depleted ATP content in the mast cells and blocked compound 48/80-induced histamine release. The inhibition of compound...
84,694
[ -0.1478812, 0.1041843, 0.07378422, -0.02924911, 0.2369459, -0.004293249, -0.2049434, -0.08147121, 0.1268601, -0.1014128, 0.05224167, 0.2648262, 0.0004224613, 0.1120782, -0.5223363, 0.1563305, -0.3298356, 0.1743093, -0.2425615, 0.2270603, 0.06050722, 0.1100865, -0.1700154,...
Superiority of adriamycin-containing combination chemotherapy in the treatment of diffuse lymphoma: a Southwest Oncology Group study.
As a part of an ongoing prospective controlled trial, the Southwest Oncology Group compared the results of treatment of advanced non-Hodgkin's lymphoma with two CHOP regimens (cyclophosphamide, adriamycin, vincristine and prednisone with either low-dose bleomycin or BCG by scarification) to a COP regimen (cyclophospham...
84,706
[ -0.1395815, 0.1718204, -0.1729535, -0.6518904, -0.2631341, -0.4812048, -0.2640229, 0.03250901, 0.006311553, 0.1286117, -0.1622176, -0.2277623, 0.09207062, 0.2364521, -0.2842479, -0.2698689, 0.3376858, 0.1382951, 0.5854208, 0.0764337, -0.08782563, 0.009935993, -0.0617368, ...
Prenatal diagnosis of polycystic kidneys and encephalocele (Meckel syndrome).
Two unrelated families are presented with repeated occurrences of a congenital syndrome of which the main stigmata were polycystic kidneys and occipital encephalocele (Meckel syndrome). Prenatal diagnosis, followed by interruption of pregnancy, was performed in one case. The diagnosis was based on an increase of amniot...
84,722
[ -0.05437959, -0.1702348, -0.2367668, -0.13969, 0.6123632, -0.3659553, -0.09765291, -0.02019589, 0.1194146, 0.1417935, 0.08966572, 0.2733305, -0.1196126, 0.02238441, -0.0369356, -0.1324399, -0.6460183, -0.2345807, -0.2866528, -0.02691959, 0.1802884, -0.07587928, -0.1212761...
Long survival in patients with bronchogenic carcinoma complicated by superior vena caval obstruction.
When superior vena caval obstruction complicates cancer of the lung; the prognosis is grave; 1 percent of such patients survive for one year. Improved palliation is reported from many radiation therapy centers using higher initial dose fractions and tumoricidal doses. We now report the findings in three patients with h...
84,732
[ 0.0874257, -0.06339201, -0.3870175, -0.3662613, -0.1245853, -0.2038452, -0.004369346, -0.3095035, -0.1361515, 0.0779923, 0.02303472, 0.2492651, -0.3160355, 0.07706247, 0.1864755, -0.2854709, 0.0999957, 0.1740065, 0.428431, 0.3234351, 0.3658129, 0.4705553, -0.01584657, 0...
Quantitative assessment of photic driving in renal failure.
Photically driven EEGs were recorded from patients with renal disease using photic stimulation at integer rates between 3 and 12 flashes/sec. Changes in the structure of the power spectrum of the potentials produced by this stimulus paradigm are described as a function of a patient's clinical state. The basic overall f...
84,740
[ -0.09047503, 0.1913176, -0.525257, 0.1204297, 0.2193307, -0.3767124, 0.1007929, -0.1964481, 0.03663354, -0.07258309, 0.07494978, -0.2108362, -0.1493521, 0.01301108, -0.4415104, 0.08814583, -0.4446033, 0.1469761, -0.3423246, 0.08714348, 0.1295786, 0.2436714, 0.0773397, 0...
[Temporal organization of paroxysmal discharges in the child. II. Polygraphic recordings during sleep].
A study of the paroxysmal activities in the course of all night sleep was carried out on 6 children aged 6 to 12 years, who were previously recored by means of biotelemtry during the day (cf. Findji et al. 1978). The discharges were analysed and quantified in the same way as in daytime but here in relation to the organ...
84,742
[ 0.05659581, -0.009606444, -0.04035187, 0.2521555, 0.2209343, -0.3560362, -0.1507482, -0.1134798, -0.06176277, 0.1359117, -0.1197799, -0.05432077, -0.1104639, -0.1943022, -0.356239, -0.115094, 0.04118347, 0.3142784, 0.3362075, 0.1175377, 0.2873246, -0.07126163, -0.09920499...
Aberrant peptide hormones in patients with urogenital carcinomas.
A series of 229 patients with urogenital carcinomas were investigated for aberrant peptide hormone activities. Serum TSH and prolactin were frequently measured in elevated levels and showed some relation to the stage of disease. Ectopic production of beta-HCG was not observed in any of the cases, thyroid and steroid ho...
84,758
[ -0.2064839, -0.201702, -0.5780486, -0.3071532, -0.01932066, -0.2013077, -0.3092072, 0.1324423, -0.02403754, 0.3039435, 0.1512711, 0.3006514, 0.1324762, 0.04201829, 0.1429064, 0.02897621, -0.3919733, -0.2099234, 0.1906044, -0.2576469, 0.3779795, 0.1473878, -0.07096858, -...
Sensitivity of human lymphocytes to bleomycin increases with age.
The sensitivity of human peripheral blood lymphocytes to bleomycin and mitomycin-C was assessed by measuring the inhibition of phytohemagglutinin stimulated proliferation. The sensitivity to bleomycin, and not to mitomycin-C, increased with the age.
84,764
[ 0.01877283, -0.4172846, -0.333511, -0.2044074, 0.01146812, -0.06469345, -0.2273031, 0.02193756, -0.0766414, 0.07122624, 0.145403, 0.2656222, 0.01747297, 0.2096812, -0.155512, -0.3995648, -0.1149488, 0.189612, -0.1780208, 0.2756133, 0.5320508, 0.1094085, 0.1508903, -0.29...
Interphase studies with a simplified method of silver staining of nucleoli.
A simple silver staining method is presented providing a rapid and reliable technique for the selective staining of nuclear structures synthesizing ribosomal RNA (18S and 28S RNA).
84,766
[ -0.0297535, 0.3834251, 0.1583578, -0.02728572, 0.04366918, -0.1398231, -0.2116382, -0.08919095, 0.3148199, 0.0725593, -0.1103522, -0.1424488, 0.2091931, 0.3181393, -0.1886832, -0.1145948, -0.1992822, 0.1049118, -0.3752874, 0.1615369, 0.357563, 0.1059015, 0.0624914, 0.13...
Liposomes in immunology: further evidence for the adjuvant activity of liposomes.
The immune response to HSA-phosphatidylcholine complexes administered to rabbits was not markedly enhanced when compared with the response to unmodified HSA. It was found in earlier work that HSA entrapped in liposomes (mainly composed of phosphatidylcholine) evoked a strong immune response under conditions where no re...
84,783
[ 0.1292483, 0.0340656, -0.2296378, 0.01275066, 0.08992303, -0.04956668, -0.1326091, -0.01651711, -0.06756056, -0.002391909, -0.03102784, -0.000258589, 0.138764, -0.06432021, -0.5571175, -0.08116107, -0.2943979, 0.1542384, 0.06372371, 0.329272, 0.3081514, 0.08907753, 0.0494...
Serum proteins and secretory component in human carious dentin.
By the use of the peroxidase-labeled antibody method, significant localization of IgG, IgA, albumin and transferrin was demonstrated in the deep lesion of 20 carious teeth, where the secretory component was absent. These serum proteins formed a distinct zone, surrounding the overlying, shallow lesion infected with bact...
84,822
[ 0.0389608, 0.06395863, -0.03293624, 0.06204667, -0.4962541, -0.2391476, -0.2130957, 0.2283653, 0.3535363, 0.2943827, 0.04625074, 0.2373705, -0.1326911, -0.01433809, 0.1123015, -0.4942617, -0.3082354, -0.2862017, -0.03178708, -0.2061253, 0.2030544, 0.1280612, -0.0287456, ...
A simple reliable system for studying antigen-specific murine T cell proliferation.
Antigen-specific T cell proliferation can be readily elicited from the popliteal lymph node cells of mice which have received immunizations of antigen in the hind footpads. The advantages of our system over other published methods are (i) simplicity in method and materials, (ii) much improved reproducibility, (iii) neg...
84,843
[ -0.05147371, -0.2192041, -0.04477349, 0.1616979, 0.2939004, -0.4770777, -0.1066901, 0.2858166, 0.02707753, 0.01987034, -0.2354488, -0.06110625, 0.1883336, 0.202109, -0.5824248, -0.3515065, -0.3734405, -0.1564403, -0.3913801, 0.4515101, 0.2485589, 0.04203115, -0.02984701, ...
Clinical and theoretical aspects of head movement dependent oscillopsia (HMDO). A review.
Head movement-dependent oscillopsia (HMDO) with peripheral vestibular, brainstem and cerebellar lesions is reviewed. The differentiation of this kind of oscillopsia is based mainly on clinical grounds. HMDO with bilateral abolition of caloric responses, and in the absence of disease of the central nervous system, is du...
84,858
[ -0.3433451, -0.3367763, 0.05546971, -0.2591236, 0.2795545, -0.6081874, 0.1561815, -0.2430089, -0.05459678, 0.1286194, 0.140377, 0.02893799, -0.1672097, -0.2429433, 0.152666, -0.1947305, -0.5960877, 0.3332444, -0.2795491, -0.2819958, -0.0739696, -0.1488354, -0.05690023, ...
Experimental studies on hydrocarbon neuropathies induced by methyl-ethyl-ketone (MEK).
An outbreak of neuropathies among Berlin solvent sniffers was closely related to the denaturation by methyl-ethyl-ketone (MEK) of the mixture used. The solvent was composed of n-hexane, toluene and ethyl-acetate. Nervous system responses to chronic repeated exposure to 10,000 ppm pure n-hexane, 10,000 ppm MEK/n-hexane ...
84,859
[ -0.1206127, -0.003336939, -0.1212886, -0.2331798, -0.0167068, -0.2385608, 0.04868637, -0.1438115, -0.01016823, -0.04185965, -0.1713469, -0.3507117, 0.182484, 0.1624314, -0.1863641, -0.1566691, -0.4753472, 0.3867696, 0.2473318, 0.4550787, 0.1596138, 0.3405843, 0.1256755, ...
T and B lymphocytes in the cerebrospinal fluid of various neurological diseases.
Cerebrospinal fluids (CSF) from 66 patients with a variety of neurological disorders were studied for total protein content, absolute amount of albumin, IgA, IgG and IgM, as well as their quotients (fraction to total protein ratio), cell numbers and B cell and T cell levels. In addition, the percentage of B cells and T...
84,862
[ -0.1516983, -0.2014535, -0.2043081, -0.05399597, -0.04901494, -0.5067879, 0.1585524, 0.2151208, -0.3003234, 0.2240372, 0.04222704, 0.02507003, 0.09670432, 0.1393252, -0.2524002, -0.1429438, 0.08892743, 0.2332951, -0.2057418, 0.3042336, 0.01760295, -0.06508204, 0.1079019, ...
Immunocytochemical localization of human choriogonadotropin in human malignant trophoblast. Model for human choriogonadotropin secretion.
Human choriogonadotropin (HCG) and its subunits have been studied immunocytochemically using a recently developed unlabeled antibody method. Factors influencing the antigenicity of HCG and its subunits were explored, and optimum conditions were determined. HCG has been successfully localized at the cellular level using...
84,888
[ 0.2932603, -0.22697, -0.3800533, -0.05542431, 0.03431414, -0.1333958, -0.1563087, 0.1397192, 0.1778285, 0.2844203, 0.01939118, -0.1033582, -0.1034148, 0.1132481, 0.0496003, -0.2357473, -0.2696566, -0.102358, -0.3230812, 0.05334798, 0.2906142, 0.3034794, -0.1734728, 0.05...
Rapid diagnosis of Bacteroides infections by indirect immunofluorescence assay of clinical specimens.
43 specimens from a variety of sites were directly examined by indirect immunofluorescence assay (I.F.A.) with specific antisera against the capsular polysaccharide of Bacteroides fragilis and pooled antisera against a number of serotypes of Bacteroides sp. (all of the former B. fragilis subspecies). The findings were ...
84,899
[ 0.0285312, 0.01468306, 0.09608671, -0.0004400271, 0.09991014, -0.01199813, -0.1267943, 0.4651479, 0.01530157, -0.1275448, 0.08465011, 0.1986026, 0.0822209, -0.04745404, 0.01850588, -0.7599376, -0.4016236, 0.07098049, -0.1782636, 0.1777727, 0.2907065, -0.02668744, -0.14026...
Congenital rubella deafness: a preventable disease.
Over a 4-year period (1972-75) an unselected sample of 568 children aged under 4 years attending the Nuffield Hearing and Speech Centre were tested for rubella antibody. Sensorineural deafness was subsequently diagnosed in 349 of these children, and 83 (24%) of this group had rubella antibody. In contrast, only 19 (9%)...
84,910
[ -0.1950122, -0.1612825, -0.01822645, 0.05501112, 0.1274571, -0.2652971, -0.1909904, -0.1847778, 0.1132256, 0.1664726, 0.458955, 0.1427826, 0.00396064, -0.198126, 0.3864097, -0.191768, -0.1867031, 0.07010351, -0.0325932, -0.05008064, 0.07665701, 0.1082996, 0.05016084, -0...
Cardiovascular disease in patients with retinal arterial occlusion.
103 patients with retinal-artery occlusion causing permanent visual-field defect were examined clinically and angiographically to assess the extent of cardiovascular disease. The 68 patients with branch-artery occlusion had a higher prevalence of previous transient episodes, ischaemic and valvular heart-disease, and mo...
84,946
[ 0.07438449, 0.1489479, -0.1925222, -0.2303001, -0.03157242, -0.4742004, 0.2221548, -0.05556304, -0.0867566, 0.0006084339, 0.1055429, 0.259374, -0.1511847, -0.193324, 0.1834958, -0.02499443, -0.5594405, 0.3100124, 0.3046055, -0.04100438, 0.007924177, 0.2563369, -0.1031653,...
Delay in diagnosis and treatment of symptomatic colorectal cancer.
Mean delay between the onset of symptoms and treatment was 30.5 weeks in a hundred patients with colonic carcinoma and 38 weeks in a hundred patients with rectal carcinoma. Most of this delay occurred outside hospital and delays attributable to the patient and family doctor were almost equal in duration. Patient delay ...
84,959
[ 0.06046574, 0.02168049, -0.367546, -0.1602806, 0.2243852, -0.3472366, 0.1928885, -0.3599164, -0.1598998, -0.06060409, 0.1995942, 0.3624791, -0.07518081, -0.2932078, -0.2710202, -0.1472346, -0.216966, 0.171039, -0.06814943, 0.04260902, 0.3874451, 0.2550648, 0.04209665, 0...
Rapid emergence of El Tor Vibrio cholerae resistant to antimicrobial agents during first six months of fourth cholera epidemic in Tanzania.
110 El Tor Vibrio cholerae isolates from 102 patients with cholera between November, 1977, and March, 1978, during the early stages of the fourth epidemic of cholera in Tanzania had minimum inhibitory concentrations to tetracycline, chloramphenicol, nitrofurantoin, neomycin, ampicillin, and sulphadimidine determined. A...
85,001
[ -0.1594018, -0.06887744, -0.1736773, -0.3187303, -0.1729327, -0.1171788, -0.1705764, -0.06253218, 0.2055265, -0.04401824, 0.1977829, 0.05862056, -0.01777179, 0.1657903, 0.05124416, -0.4249618, -0.4336563, 0.1156042, -0.1764046, 0.2827776, 0.03164149, 0.2319137, -0.1519886...
Diagnostic value of rectal mucosal acetylcholinesterase levels in Hirschsprung's disease.
Acetylcholinesterase (AChE) activity was measured in rectal biopsy specimens obtained from 68 children aged between 2 days and 14 1/2 years in whom Hirschsprung's disease was suspected. The diagnosis was subsequently established in 12; in these, the mean AChE activity was found to be 30.5 X 10(-7) units/g tissue (range...
85,002
[ -0.07082029, -0.2105594, -0.2989038, -0.179573, -0.1530817, -0.1854617, -0.1775023, -0.02168941, -0.01215146, -0.04186782, 0.4083432, 0.3257107, 0.1129035, 0.02906918, -0.4822269, -0.04031683, -0.6888709, 0.1253911, 0.02107446, 0.2986589, 0.4128881, -0.02074947, -0.174559...
Fulminant psittacosis.
Two patients died of psittacosis after presenting with generalised toxaemia, acute renal failure, and evidence of pancreatitis. Death was attributed to the virulence of the chlamydial strain and the delay in antemortem diagnosis. In one case Chlamydia psittaci was isolated from necropsy lung tissue. A third case of psi...
85,004
[ -0.3460262, -0.07238217, 0.09776983, 0.08912782, 0.002138697, -0.0451767, -0.1121221, -0.002324369, -0.2611077, -0.1235963, 0.4310978, 0.05224113, -0.0619514, 0.3806685, 0.298512, -0.2280921, -0.1058484, -0.1377122, -0.04032673, 0.02715847, -0.02479752, 0.2225147, -0.2386...
Dried-blood spot screening for cystic fibrosis in the newborn.
Serum-immunoreactive-trypsin (I.R.T.) was measured in children with cystic fibrosis (C.F.) and a variety of controls. In the first few months of life all C.F. children had a raised serum-I.R.T. A dried blood-spot assay for I.R.T. was established and has potential as a screening test for C.F. in the newborn.
85,057
[ -0.07523744, -0.02120056, -0.1182567, -0.07566392, 0.06482778, -0.09782866, -0.120321, 0.2666695, 0.1165505, 0.1694809, 0.291117, 0.5891023, -0.176791, 0.009566585, -0.3216164, -0.4183616, -0.3868243, -0.06151403, 0.212974, -0.06915944, -0.1599932, 0.1335212, -0.239486, ...
Transmission of non-A non-B hepatitis to chimpanzees by factor-IX concentrates after fatal complications in patients with chronic liver disease.
6 cases of non-A non-B hepatitis which followed administration of four different batches of concentrates of coagulation factor IX from commercial and non-commercial sources are described. Of 17 patients who received the concentrate on account of chronic liver disease, 4 developed hepatitis, and in 3 of these the illnes...
85,107
[ -0.3911938, -0.003245721, -0.08382711, 0.1057269, 0.1585153, -0.4809023, -0.3105547, 0.1056017, -0.05720069, 0.02022201, -0.07636144, 0.0370814, 0.3372461, -0.05914119, -0.298703, -0.1543136, 0.1686826, -0.2863324, -0.06503483, 0.404841, 0.2478513, 0.1902212, -0.1075102, ...
Evidence that Alzheimer neurofibrillary tangles originate from neurotubules.
Antiserum against normal human neurotubules purified by in-vitro assembly precipitated both neurotubules and a polypeptide isolated from Alzheimer neurofibrillary tangles in Ouchterlony double-diffusion tests. The antiserum specifically labelled neurofibrillary tangles, in isolated neurons by immunofluorescence and in ...
85,165
[ -0.03183131, -0.3668967, -0.1302683, -0.0445332, -0.146485, -0.1012545, -0.3944123, 0.09914719, 0.1352509, 0.256444, 0.106731, 0.1245568, 0.1862029, -0.01105356, -0.3036494, 0.145674, -0.4948685, 0.197485, 0.003405445, 0.1734618, 0.2210848, 0.03643218, 0.01770792, -0.05...
Inhibition of prostaglandin synthesis as a treatment for biliary pain.
Twenty patients with confirmed gallbladder disease were treated with intravenous indomethacin during 24 separate attacks of biliary pain. In all cases the pain was promptly relieved and there were no important side-effects. Indomethacin, and inhibitor of prostaglandin synthesis, may reduce intraluminal pressure in the ...
85,168
[ -0.1442456, 0.1641975, -0.1303138, -0.0771597, -0.1952279, -0.09989028, -0.1639178, -0.04467983, 0.08984477, -0.1922222, 0.1111864, 0.007086062, -0.1802826, 0.03811185, -0.1249797, -0.161995, -0.3472352, 0.1049094, -0.0728156, 0.1553486, 0.1305115, 0.1270369, -0.03118681,...
Murine model for immunoprophylaxis of cytomegalovirus infection. I. Efficacy of immunization.
Murine cytomegalovirus was utilized as a model for human cytomegalovirus, which had no experimental animal, to study immunoprophylaxis of the cytomegalovirus infections. (1) Murine cytomegalovirus (MCMV) serially propagated in mouse embryonic fibroblasts had lost pathogenicity for weanling mice including neonatally thy...
85,239
[ -0.1314178, -0.264507, -0.434811, -0.3215515, 0.09795154, 0.01694671, -0.2269232, 0.1374245, 0.1739074, -0.0320759, -0.01257863, 0.008697367, -0.1235888, 0.1948686, -0.4670143, -0.02436125, -0.3220965, 0.01957558, -0.08590834, 0.3804536, 0.1327825, 0.0995703, -0.1001381, ...
Recognition of antigens by T lymphocytes.
The present review briefly summarizes our knowledge of antigen-specific B and T lymphocyte receptors. Antigen-specific receptors on mammalian B lymphocytes are mainly monomeric IgM and IgD consisting of conventional immunoglobulin heavy and light chains. The nature of the T lymphocyte receptor which can specifically re...
85,255
[ -0.09357497, -0.09913873, -0.1827421, -0.1483605, 0.3653788, -0.5428333, -0.1108291, 0.2080175, -0.01325514, 0.5027286, 0.0415117, -0.04294292, 0.3061844, 0.08948083, -0.53173, -0.3134954, -0.276178, 0.2420283, 0.04656033, 0.0477682, 0.2879441, 0.2478726, -0.06570508, -...
[The lupus erythematosus (LE) phenomenon. Status in 1978].
The results of 835 studies of LE cells carried out over 8 years in 563 clinical cases of various nature are reported. The LE phenomenon--i.e. LE cells, LE globs and rosettes--was encountered exclusively in patients with LES, whereas tart-cells, nucleophagocytosis A and nucleophagocytosis B, although present in initial ...
85,283
[ 0.1342164, -0.1278792, 0.03041088, 0.1186241, 0.2297567, -0.3935414, -0.144112, -0.1509739, 0.01436404, 0.275194, 0.04737685, 0.4080056, 0.08205472, 0.180665, -0.3645442, -0.1198858, -0.3322532, -0.02633603, 0.3348636, 0.09974876, 0.3040239, 0.02576576, -0.2067032, -0.1...
Microbial-like antigens in human leukemia.
Antigens present in leukemic sera and organ extracts, but absent from non-leukemic sera and tissues, were detected by examining their reactions with anti-microbial antisera by means of counter-immunoelectrophoresis. Out of 110 different antisera used, 12 antisera, those produced against Micropolyspora, Coccidioides, Sa...
85,287
[ -0.3976646, -0.3185199, 0.1008779, 0.03058719, 0.09052135, 0.03734991, -0.5390731, 0.1170018, -0.1541007, 0.2447845, 0.05723742, 0.1281869, 0.09577999, 0.09999773, -0.4207493, 0.06314072, -0.6583711, -0.08380444, 0.02272489, -0.03474673, 0.4950503, -0.09748101, -0.153805,...
Rapid sequence determination of late simian virus 40 16S mRNA leader by using inhibitors of reverse transcriptase.
A method for the determination of the primary structure of spliced mRNA junction and leader sequences is described. By analogy to the DNA sequencing procedure of Sanger et al. [Sanger, F., Nicklen, S. & Coulson, A. R. (1977) Proc. Natl. Acad. Sci USA 74, 5463--5467], we use 2",3'-dideoxynucleoside triphosphates as ...
85,304
[ -0.001636873, 0.2435237, -0.3355198, -0.306286, 0.5306512, 0.1036955, -0.08735162, 0.0251226, 0.3165304, -0.1848054, -0.06879734, 0.06826566, 0.3785689, -0.2942547, -0.5517495, 0.1583645, -0.1856073, 0.1206907, -0.09826396, 0.1464625, 0.4194345, 0.04097671, -0.08436097, ...
Quantitation of enzymes in tissue sections by estimation of hydrolytic activity and antigenic determinants.
The method and instrumentation for the analysis of enzyme activity and of fluorescent antibody of antigen binding is described. It is based on the microscopic photometry of stain intensities per area of functional units. Thus it was shown that the concentration of aminopeptidase (EC 3.4.2.1) per area in procimal tubule...
85,312
[ 0.04791936, -0.3167937, -0.2911412, 0.2810989, 0.220218, -0.2385358, 0.04550132, 0.1403943, 0.2523265, 0.0125853, -0.03416483, -0.3613993, 0.1200183, -0.05611926, -0.6700099, 0.09701618, -0.6903476, 0.2495825, -0.1505499, 0.3664414, 0.2861761, 0.104011, -0.05805366, -0....
Lymphoblastoid cell lines are polyclonal activators of human T lymphocytes.
Following stimulation with autologous or allogeneic lymphoblastoid cell lines (LCL) human T lymphocytes acquire two properties which suggest that LCL act as polyclonal activators. Cytotoxic activity, which has an antigen-specific component, is produced towards normal lymphocytes and LCL, and the cells become capable of...
85,333
[ -0.07876702, -0.2602089, -0.3967342, -0.2257451, 0.3814499, -0.1220405, -0.2929659, 0.4241157, 0.02166735, 0.2877465, -0.07503942, 0.2747321, -0.05527778, -0.02190178, -0.2454865, -0.09753733, -0.3781893, -0.1489077, 0.04753134, 0.2975591, 0.6211213, 0.3142753, -0.1148093...
[Oncornavirus activation and accumulation in cell cultures under the influence of hormones].
Sex hormones (testosterone, estradiol) and thyroxine would activate irregularly the production of the specific group antigen (GS-antigen) of avian ribodesoxyviruses in the culture of "normal" chick embryonal cells (CEC, phenotype C/O, GS-). The mentioned hormones as well as hydrocortisone and insulin would not prevent ...
85,368
[ 0.1466068, 0.04268014, -0.3159548, -0.5149779, 0.1923338, -0.0838531, 0.02364009, -0.03672777, -0.3603424, 0.1864795, -0.0627157, 0.2920965, 0.2574669, 0.08615974, -0.5855573, -0.2464076, -0.260082, -0.3095963, 0.08633646, 0.3488444, 0.4149865, -0.01383709, -0.3695154, ...
[Antigenicity of the human trophoblast].
In this a rabbit immunological serum against human trophoblast was obtained after triple intramuscular superficial villi extract injection from chorion of 6--7 week pregnancy with Freund's adjuvant. In immunofluorescent indirect reaction to this serum made on chorion and placenta sections some most intense specific flu...
85,393
[ 0.2530443, 0.01248979, -0.04316107, 0.1157259, 0.1986773, -0.3116102, -0.3288927, 0.06572863, 0.2093879, 0.04951375, 0.050623, -0.002436667, 0.1946298, -0.07062829, -0.2482797, -0.5180118, -0.5143497, 0.008905259, -0.152178, 0.4893894, 0.2920752, 0.2296263, -0.117391, 0...
[Improvement in the tactics of systematic gamma globulin prevention of viral hepatitis taking the morbidity prognosis into account].
On the example of 4 cites of the RSFSR under conditions of expected epidemic threat a possibility was shown of directed influence on the viral hepatitis A epidemic process of preseasonal gamma-globulin prophylaxis conducted in 90% of "organized" children, aged from 1 to 12 years. The dose used was 0.75 ml of a 10% prep...
85,395
[ 0.173292, -0.1893339, -0.2790007, -0.003197555, 0.2076594, -0.09867579, -0.2738527, -0.09417614, -0.1768421, 0.1650099, 0.1042073, 0.2008342, 0.1198929, 0.2244533, -0.4822216, -0.2108127, 0.2879982, -0.09548674, 0.2753668, 0.3686314, 0.458817, 0.09486273, -0.2901515, -0...
[Makeup and properties of a polycomponent meningococcal vaccine].
The polycomponent meningococcae vaccine represented a preparation of the high-molecular fraction of meningococcus cell wall substances. Meningococcae strains for the vaccine preparation were chosen in such a way that the end preparation contained antigens of group specificity A, B, C and also other antigens detected in...
85,399
[ 0.01458633, 0.1467439, 0.06413551, -0.06875541, 0.1201842, -0.264862, -0.1916442, 0.05996799, 0.1239416, 0.1435714, 0.02851261, -0.02434079, 0.1449322, -0.0442994, -0.4628772, -0.008156773, -0.3811826, 0.1574439, 0.06763502, 0.4164473, 0.5530579, 0.1043047, -0.09127682, ...
Histochemical demonstration of acidic glycosaminoglycans in the cell nuclei of the iris and other tissues.
Using histochemical methods, the presence of acidic glycosaminoglycans in the cell nuclei of 51 human irides and a series of monkey organs was demonstrated. In general, these substances are sensitive to testicular hyaluronidase and chondroitinase ABC and also to Streptomyces hyaluronidase, when using special staining m...
85,402
[ 0.1135673, -0.155684, -0.3969837, 0.22892, 0.1797879, -0.1494801, -0.1878075, 0.2392724, 0.0909701, 0.1770141, 0.1575257, -0.1586323, 0.2327007, -0.2350813, -0.1847352, 0.06011454, -0.1950862, -0.08707926, 0.04591814, 0.1257268, 0.635955, -0.1547072, 0.001534068, -0.179...
Differences in mouse ovarian cells as distinguished by horseradish peroxidase labelling.
The extracellular space of mouse ovarian follicles and stroma contained horseradish peroxidase (HRP) reaction product one minute after intravenous injection of the tracer. In addition to pinocytotic uptake of the tracer, non-vesicular staining with HRP reaction product, heretofore unrecognized, was noted in a variety o...
85,420
[ -0.06860106, -0.2687158, -0.1016553, 0.01375587, 0.187844, -0.2649766, 0.3942583, 0.1244477, -0.013073, 0.3461256, -0.06852575, 0.02143734, -0.1631976, -0.06435205, -0.3767046, -0.1123469, -0.3413258, 0.2488547, 0.3266604, 0.009870226, -0.07054823, 0.1105401, 0.04715934, ...
The effect of alkaline earth cations on the release of histamine from rat peritoneal mast cells treated with compound 48/80 and peptide 401.
1 Extracellular calcium ions have a dual effect on the release of histamine from rat peritoneal mast cells treated with compound 48/80 and peptide 401. The release is either potentiated or inhibited according to the relative concentrations of ion and inducer.2 Strontium similarly potentiates the release produced by opt...
85,466
[ -0.2015267, -0.01200022, -0.1443675, -0.07470186, 0.1581604, -0.06451391, 0.01799233, 0.007911744, 0.2374688, 0.2492893, -0.2042452, 0.125178, 0.03813125, -0.2165987, -0.198721, 0.0768991, -0.3284151, -0.008554275, -0.3035803, 0.04975295, 0.1306242, 0.3146029, -0.01972963...
Role of the inferotemporal cortex in visual selective attention.
Electrocortical recordings were made from monkeys performing in a multidimensional visual task. Wave forms dependent on the stimulus presented (irrespective of task required) were recorded immediately following the stimulus primarily from electrodes implanted in the striate and prestriate cortex. Wave forms dependent o...
85,535
[ -0.01725, 0.3016873, -0.1850998, -0.3084477, -0.07003225, -0.577602, -0.1659924, -0.02480296, -0.001518806, 0.1261216, 0.1659871, -0.1251682, -0.004436172, -0.02426543, -0.5520849, -0.1859884, -0.3923324, 0.3533472, -0.08679829, 0.0777549, 0.4898055, 0.05193239, 0.1154539...
Quantified electrographic scales on 10 pre-term healthy newborns followed up to 40-43 weeks of conceptional age by serial polygraphic recordings.
Full-term newborns with seizures exhibit EEG patterns that appear reliable in predicting neurological outcome in almost 75% of the cases in a prospective investigation. These patterns are unreliable for over 25% of infants with seizures and even more so for term and pre-term babies with other complications. Observation...
85,542
[ 0.1288855, -0.1072734, -0.4422168, -0.2390385, -0.00132962, -0.437222, -0.1386565, -0.3364985, 0.06344082, 0.09346306, -0.1809596, 0.1066592, 0.02478872, 0.1349614, -0.1802171, 0.1608452, -0.3521259, 0.3602074, 0.01959764, -0.04793131, 0.2543462, 0.131978, 0.01262423, -...
REM sleep episodes during the Multple Sleep Latency Test in narcoleptic patients.
Forty narcoleptic patients were given the Multiple Sleep Latency Test, consisting of 20 min opportunities to sleep offered at 10.00, 12.00, 14.00, 16.00 and 18.00 o'clock. Eleven patients had 2 episodes of REM sleep, 5 had 3, 11 had 4, and 13 had 5 before they were awakened. Fourteen control subjects given similar oppo...
85,544
[ -0.2732612, 0.09500332, -0.2642713, -0.3556874, 0.09119741, -0.07250735, -0.422132, -0.2012578, 0.05983417, -0.1850984, 0.18462, 0.5285273, 0.1770912, 0.1208811, -0.4055493, 0.07495249, -0.4343088, 0.3524587, 0.3028567, -0.02334455, -0.1417209, 0.1315155, 0.08455998, -0...
[Classification of non-Hodgkin's lymphomas: facts and perspectives].
Previous classifications of malignant non-Hodgkin lymphomas (nHL) are based on morphological and histological-cytological findings. The rapid development of immunology, the application of immunocytological, cytochemical and electromicroscopic methods led to new classifications of nHL based on immunology. They are found...
85,568
[ -0.007919471, -0.1853541, -0.01868869, -0.3301547, 0.1383637, -0.2537262, 0.155671, 0.03913458, -0.1651036, 0.5223808, -0.06145992, 0.003222582, 0.227149, 0.08701571, -0.5858969, -0.1493442, -0.09599809, 0.02136311, 0.3113982, 0.1990747, 0.5543393, 0.1175547, -0.1249302, ...
The economic side of blood banking and plasma fractionation.
While cellular components have a relatively short half-life, must be necessarily administered group-specifically and kept available on a round-the-clock basis, all of which add significantly to the basic cost per unit, products isolated from plasma are not handicapped by these disadvantages. Another important advantage...
85,581
[ -0.3169676, 0.4150013, -0.1783306, 0.08226183, 0.1651735, -0.4077646, -0.03710171, 0.223497, -0.06469969, 0.2351104, 0.01917813, -0.02645824, 0.03889706, 0.1041856, -0.3197342, -0.1701896, 0.2635554, 0.05553568, -0.0538594, -0.02255867, 0.3200972, 0.4892685, -0.03186544, ...
Immunostimulatory effect of zinc in patients with acute lymphoblastic leukemia.
The studies have been performed in 27 ALL patients, aged 4 to 21 years, during their first remission induced by the Memphis Center therapeutic schedule (New Eng. J. Med., 1974, 5, 1230). The onset of therapy with zinc took place immediately after cessation of remission supporting treatment (Vincristine, Prednison, intr...
85,583
[ 0.2106891, -0.04305884, -0.3465906, -0.0720684, -0.05277273, -0.1893363, -0.04848428, 0.04184125, 0.01389885, 0.02219153, -0.03463653, 0.2257807, 0.1810067, 0.1762248, -0.5388151, 0.09918603, 0.05929163, 0.2953091, -0.3473279, 0.5312361, 0.2318508, 0.1593945, 0.02030847, ...
Cultivation of fresh and frozen mouse bone marrow. - Application of methyl cellulose.
The culture of cells of both fresh and frozen mouse bone marrow on methyl cellulose (MC) was approached. We used 1.5%-concentration of MC and proved the stem cells of fresh and frozen mouse bone marrow to proliferate and form haemopoietic colonies on MC. We established that the freezing process did not significantly de...
85,584
[ -0.3615796, -0.02390925, -0.01651276, -0.04303055, 0.09700754, 0.144849, -0.1820986, 0.3245776, 0.0311695, 0.04837967, -0.05153072, 0.2236042, -0.2647406, 0.1718748, -0.5750723, -0.2892279, 0.02747073, 0.1000184, -0.3494769, 0.4576572, 0.4918909, -0.1147762, 0.01562616, ...
[Postoperative changes of the thrombocyte number and function].
In 30 patients the number of thrombocytes was determined 24-48 hours after surgical interventions and compared with the normal range. The function of thrombocytes was determined by the method of pressure registration in combined thrombocyte-aggregation-adhesion (DKTA method). In spite of the occurring thrombocytosis th...
85,594
[ 0.1022989, 0.08499753, -0.1006866, -0.4550305, -0.1076509, -0.7190372, 0.07919735, 0.2010498, 0.2445893, 0.03814377, -0.004915101, -0.07605463, -0.1032477, -0.2285834, -0.4926279, -0.2136795, 0.05549011, -0.04189674, 0.08209616, 0.3699049, 0.5096329, 0.07157752, -0.363422...
Thermonuclease seroinhibition test for distinguishing Staphylococcus aureus from other coagulase-positive staphylococci.
Since coagulase-positive staphylococci from animals are heterogeneous, another test is necessary to distinguish Staphylococcus aureus from them. Staphylococcal thermonucleases appear to be heterogeneous; antisera raised against S. aureus isolated from humans inhibit thermonuclease activity as demonstrated by the metach...
85,633
[ -0.06919781, -0.170392, 0.1953861, -0.06141659, -0.2782023, -0.007818026, -0.3309549, -0.006331491, 0.2124681, -0.19555, 0.3060925, 0.2915494, 0.1629274, -0.06532152, -0.2049858, -0.07181042, -0.3902552, 0.1023694, -0.2405033, 0.3347681, 0.3008734, 0.3339689, 0.1403338, ...
The escape of cyclic AMP from human diploid fibroblasts: general properties.
A variety of human diploid fibroblasts released large amounts of cAMP to the medium in a time-dependent fashion concomitant with stimulation of the cells by agonists of the adenylate cyclase. In WI-38 cells increased medium cAMP levels were detectable as quickly as increased cellular levels. Escape was not secondary to...
85,640
[ -0.2988763, -0.2116969, -0.327344, -0.3429662, 0.2225964, -0.1673206, -0.2336177, 0.2317001, 0.2256578, 0.1116077, 0.1319362, 0.06071866, 0.1269452, 0.2035122, -0.4585235, -0.07567555, -0.2451267, -0.1740767, -0.4919997, 0.6664044, 0.3694286, 0.08406453, -0.217899, 0.04...
The audio-visual revolution: do we really need it?
In the United Kingdom, The audio-visual revolution has steadily gained converts in the nursing profession. Nurse tutor courses now contain information on the techniques of educational technology and schools of nursing increasingly own (or wish to own) many of the sophisticated electronic aids to teaching that abound. T...
85,645
[ -0.4261055, 0.06233088, -0.2299509, -0.3005871, 0.1919935, -0.2409869, -0.05037614, -0.08616869, 0.07601803, -0.113942, 0.1035471, 0.09328426, -0.08214185, -0.07605158, -0.07002594, -0.02275462, -0.2293695, -0.04964666, -0.2027943, -0.2828362, 0.06771418, 0.449432, -0.131...
Distinct functions of monoclonal IgG antibody depend on antigen-site specificities.
Intraveneous hyperimmunization of selectivity bred rabbits with streptococcal group A-variant vaccines elicits antibody responses of restricted heterogeneity at high antibody levels. All antisera contain two functionally distinct antibody populations, which can be isolated in single-band purity upon analytical isoelect...
85,686
[ -0.1359172, -0.1158253, -0.2802724, 0.1480047, 0.04276448, -0.1106636, -0.09805395, -0.08450907, -0.03768808, 0.2771496, 0.2733499, 0.2133734, -0.02498913, 0.06520317, -0.2167837, -0.2233514, -0.4710521, 0.1863996, 0.2747084, 0.1296279, 0.2857006, 0.2766269, -0.1415641, ...
Serological definition of the lentivirus group of retroviruses.
The major polypeptides of visna viruses and other lentiviruses have been isolated and shown to be closely related if not identical in radioimmunoassays. By this criterion the lentiviruses form a distinct group of retroviruses unrelated to spuma viruses, mammalian and avian retroviruses that cause tumors, and unclassifi...
85,722
[ 0.1700396, -0.2916606, 0.1184283, -0.2181427, 0.1790827, -0.1207826, -0.2392273, -0.007286751, -0.0693161, 0.04354424, -0.003762798, 0.0508865, 0.3742114, -0.02447179, -0.2723305, -0.05101681, -0.4318604, 0.1191119, 0.3376975, -0.04844369, 0.4635908, -0.1549061, -0.171461...
Rosettes from Friend leukemia virus envelope: preparation and physicochemical and partial biological characterization.
Rosette-shaped particles mainly containing gp85 were isolated from Friend leukemia virus. The isolation procedure comprised lysis of the virion by Triton X-100, affinity chromatography on concanavalin A-Sepharose, and velocity sedimentation. The rosettes displayed a mean sedimentation constant of 32S and a buoyant dens...
85,724
[ -0.03003992, -0.07594744, -0.211765, 0.07866308, 0.2928428, -0.04190501, 0.06468427, -0.05706791, 0.02393741, 0.3731847, 0.03665213, 0.2244529, -0.05204855, 0.2583999, -0.02980748, 0.1569066, -0.2307975, -0.05726907, -0.07915732, 0.293557, 0.3171677, 0.1753724, -0.1160599...
A method for the identification and detection of alpha-fetoprotein.
This paper describes the detection and identification of alpha-fetoprotein (AFP) using a simple, economical, time saving and sensitive method. Twelve serum samples can be evaluated at the same time. Antigens are precipitated within 45--60 minutes on a cellulose acetate membrane by counter-immunoelectrophoresis. This me...
85,735
[ -0.09412951, 0.05068988, -0.1329867, -0.006144109, 0.243111, -0.0846308, -0.4987641, 0.3836456, 0.003847247, 0.2051856, -0.05354334, 0.2253679, 0.2985739, -0.00214066, -0.1295879, -0.03582814, -0.1939459, -0.03415225, -0.2996351, -0.0005925405, 0.2869124, -0.02403588, -0....
Carrier detection in Duchenne muscular dystrophy: Assessment of the effect of age on detection-rate with serum-creatine-kinase-activity.
In 40 known carriers of the gene for Duchenne muscular dystrophy (mean age 38 years) the detection-rate with a standard assay of serum-creatine-kinase was 53%. In 52 daughters of known carriers (mean age 16 years) the detection-rate was 45% after correction of age. This implies a much higher detection-rate (about 90%) ...
85,935
[ -0.08583587, -0.04392859, -0.1143062, -0.2596588, 0.02607487, -0.1070881, -0.1380621, 0.04864824, -0.1157172, -0.077831, 0.2251886, 0.4731413, 0.2224671, 0.1728637, -0.3596934, -0.2333082, -0.327116, 0.0875344, -0.01223225, 0.2459721, 0.3888948, 0.1172511, -0.1357848, -...
Biochemical and haematological changes induced by tienilic acid combined with propranolol in essential hypertension.
Sixteen patients with moderate essential hypertension completed a double-blind crossover trial with four treatment periods each of 6 weeks. They received in random order: placebo; tienilic acid 250 mg/day; propranolol 80 mg twice daily; and tienilic acid 250 mg/day combined with propranolol 80 mg twice daily. Average b...
85,937
[ 0.002134175, 0.1372561, 0.0741169, 0.04765918, 0.2315089, -0.211052, -0.3474331, 0.08956999, 0.3041019, -0.2583945, -0.09958762, 0.6059775, 0.01683296, 0.3729956, -0.724237, 0.15115, -0.4340818, 0.05078196, -0.3472093, 0.6228047, -0.4364038, 0.3270768, -0.05282243, -0.0...
Modified Feulgen staining of DNA with aqueous solution of pinacyanol.
The paper reports on the use of a quinoline dye, pinacyanol, towards staining of acid hydrolysed DNA. The dye as an aqueous solution can be used after treatment of mammalian tissue sections in concentrated phosphoric acid at 5 degrees C for 20 min followed by hydrolysis in 6N HCl at room temperature for 15 min, for sta...
86,146
[ -0.2149659, 0.0192664, -0.3415258, 0.0625683, 0.1619177, 0.05461469, -0.3126234, 0.008256241, 0.3912043, 0.1010051, 0.1906649, 0.1841656, 0.3026223, -0.3740074, -0.5021083, -0.1346553, -0.1564397, 0.1202393, -0.3371384, 0.5345001, 0.2441145, -0.09569646, -0.08970019, -0...
Ineffectiveness of topical adenine arabinoside 5'-monophosphate in the treatment of recurrent herpes simplex labialis.
The ability of topical 10 per cent adenine arabinoside 5'-monophosphate to decrease the severity and frequency of recurrent herpes simplex labialis was evaluated in a double-blind, randomized study of 233 patients at three collaborating institutions. Nine clinical and four virologic measurements were used to evaluate d...
86,158
[ 0.02041092, -0.2564588, -0.3117843, -0.08306753, 0.437297, -0.1062354, -0.2250982, -0.04967099, 0.1107926, -0.2117326, 0.07167331, -0.0509856, 0.144165, 0.3380725, -0.4067177, -0.0525774, -0.08179773, 0.05841546, -0.5119748, 0.3160097, 0.2284895, 0.08797693, -0.1091878, ...
Use of cis-Pt(II)-uracil for electron microscopic cytochemistry of rat brain nucleic acids.
Cis-Pt(II)-uracil staining reveals nucleic acids in a relatively specific manner when applied alone for 1 h to rat brain tissue specimens. Poor contrast and resolution are observed when glutaraldehyde-fixed and epoxyembedded thin sections are post-stained with cis-Pt(II)-uracil alone. Counterstaining thin sections with...
86,272
[ 0.1748639, 0.1101151, -0.1385582, 0.004834629, 0.1941878, -0.3498767, -0.2279606, -0.0451314, 0.0569497, 0.1460781, -0.06601896, 0.2212862, 0.3326432, -0.0658787, -0.5856495, 0.07396567, 0.1085216, 0.179044, -0.1923782, 0.2350298, -0.09272914, 0.1234414, -0.07966787, -0...
Mutants of Streptococcus lactis subsp. diacetylactis lacking diacetyl reductase activity.
Three strains of Streptococcus lactis subsp. diacetylactis, namely DRC-1, DRC-2 and DRC-3 which produced diacetyl up to 120 h of incubation were exposed to the ultraviolet irradiation as well as N-methyl-N'-nitro-N-nitrosoguanidine (NTG) to isolate mutants lacking diacetyl reductase activity. UV irradiation did not pro...
86,283
[ 0.1367587, -0.1455615, 0.1191207, -0.2648218, -0.08504566, -0.2263525, -0.1660216, -0.3708511, 0.3100621, 0.02038703, 0.196382, 0.01149466, -0.2223989, 0.009236876, -0.4258406, 0.02479751, -0.2841031, 0.1112386, 0.417533, 0.1727179, 0.4694096, 0.3961509, -0.05832531, -0...
Granulocyte transfusion therapy: state of the art.
Previously, granulocyte transfusion therapy was impractical due to insufficient yields obtained from normal donors. With the advent of such technical advances as continuous-flow centrifugation (CFC) and filtration leukapheresis (FL), the procurement of sufficient amounts of normal donor neutrophils becomes feasible. Th...
86,298
[ -0.1713822, 0.02774256, -0.005917849, -0.1849883, 0.3812681, -0.2554464, -0.08348066, -0.05084264, -0.1974491, 0.00543982, -0.1425537, 0.08110544, -0.2254931, 0.2946787, -0.1106131, -0.7210802, 0.04215111, -0.1688477, -0.2326366, 0.05335008, 0.1909166, -0.1077399, -0.0201...
The effect of some unspecific stimuli on defence mechanisms in weaned pigs.
The studies were performed to find out whether a prophylactic use of unspecific stimuli affects appreciably the selected biologic indices in weaned pigs. The variables used in the experiment were found to exert a favourable effect on the state of health and growth of pigs but they had no essential influence on the leve...
86,338
[ 0.04057296, -0.08321242, 0.06153833, 0.008466534, 0.07320108, -0.1863531, -0.1829261, -0.05974337, -0.08074173, 0.04522703, -0.0299408, -0.1754181, 0.2833181, 0.06276432, -0.3344139, -0.009249264, -0.5060408, -0.1327187, -0.1976569, 0.410576, 0.1612758, 0.1495037, -0.1967...
The effect of uremia and dialysis on cell-mediated immunity.
Delayed-type hypersensitivity to PPD, two types T rosettes as well as lymphokine production were studied in patients with end-stage renal failure maintained on hemodialysis. A significant impairment of skin reactivity and the lowering of the number of T cells were found, while no definite changes of lymphokine producti...
86,344
[ 0.04260824, -0.3345638, -0.2238054, 0.06785639, 0.5847118, -0.3811608, 0.05201138, 0.1103341, 0.02655165, 0.4423135, 0.1053055, 0.0227042, -0.01504062, 0.3380532, -0.6349124, -0.241211, 0.07763965, -0.08175655, 0.005487798, 0.1040952, 0.1569137, 0.2428354, 0.05958292, -...
Peritoneovenous shunting in the management of malignant ascites.
The incapacitating, malignant ascites of 37 patients were treated with peritoneovenous shunt using the LeVeen valve. Palliation of ascites was achieved in 27 of 37 patients until they died of their underlying diseases. In ten of the 37 patients, no long-term palliation was accomplished. Complications relating to the sh...
86,345
[ -0.1407997, -0.03538234, -0.1173951, -0.2374276, 0.03089095, -0.2942697, -0.2408081, -0.2583385, -0.2848954, 0.03730153, 0.06643581, 0.06360698, -0.1867612, 0.1328043, 0.2260587, 0.06953555, -0.1715852, -0.1419704, 0.0298896, -0.04480295, -0.01657832, 0.02321899, -0.06300...
Nerve growth factor (NGF) in the rat CNS: absence of specific retrograde axonal transport and tyrosine hydroxylase induction in locus coeruleus and substantia nigra.
Selective, highly efficient uptake of [125I]NGF by nerve terminals followed by retrograde axonal transport, and specific induction of tyrosine hydroxylase by NGF are well known phenomena in peripheral adrenergic neurons of adult rats. In the present study these parameters were used in order to detect possible interacti...
86,378
[ 0.2008133, -0.03714209, -0.219938, -0.2588541, 0.1412223, -0.5105566, -0.2333741, -0.1391933, -0.1368131, 0.1041072, 0.05469992, -0.1157566, 0.04531011, -0.04504444, -0.1721382, 0.02596829, -0.4019486, 0.1613708, 0.08048344, 0.3141591, 0.1439076, -0.04039056, 0.008724592,...
Antenatal diagnosis of neural tube defects in Canada: extension of a collaborative study.
Experience with the diagnosis of neural tube defects from alpha1-fetoprotein (AFP) concentrations in amniotic fluid is reported from a prospective study of five laboratories testing for 13 Canadian genetic centres. The results of the study indicate that antenatal diagnosis of open neural tube defects is being carried o...
86,382
[ -0.2668987, -0.2661453, -0.2415088, -0.1548083, 0.2265327, -0.2886536, -0.2434282, -0.144397, 0.1765227, -0.128251, 0.08044013, 0.3818178, 0.0536982, -0.2337128, 0.1406165, -0.2483399, -0.3585064, -0.07062411, -0.03163499, -0.08100375, 0.3577295, -0.06512696, -0.05225355,...
Prenatal diagnosis of severe congenital malformations associated with elevated amniotic fluid alpha-feto protein.
Two cases of severely malformed infants with abnormal fetal images on B-scan sonography and markedly elevated amniotic fluid AFP are presented. There was no evidence of neural tube anomalies. The importance of an amniocentesis and AFP in pregnancies with an abnormal fetal image on B-scan sonography is emphasized, takin...
86,399
[ -0.1215244, -0.2985157, -0.23684, -0.320561, 0.2310613, -0.1673744, -0.369566, -0.2480727, -0.01413434, 0.1735875, 0.1666327, 0.11298, -0.1708845, 0.1172515, 0.1122992, -0.2194049, -0.3621592, 0.03042951, 0.006877344, -0.2548036, 0.340492, -0.03343025, -0.06408649, 0.09...
Evaluation of event-related desynchronization (ERD) preceding and following voluntary self-paced movement.
A method of accurate storage and on-line preprocessing of an EEG signal, preceding and following a trigger signal, elicited by button pressing, is described. The method was used to study the changes occurring in the power of the rhythmic activity within the alpha band in central areas, during voluntary, self-paced move...
86,421
[ -0.2384577, 0.51063, -0.3259883, -0.2240683, 0.3036686, -0.5690576, -0.1646547, -0.2177566, -0.05479642, 0.02088043, -0.0192843, -0.05796105, -0.01557499, -0.3083784, -0.6928753, -0.2062896, -0.1641169, 0.01640429, -0.1218924, -0.06166944, 0.3427611, 0.1868385, 0.03561363...
Sleep induced by low doses of apomorphine in rats.
The effect of apomorphine on the EEG of freely moving rats was studied. Apomorphine at the dose of 1 mg/kg caused stereotypy and a marked reduction of total sleep. On the contrary, acute subcutaneous administration of apomorphine at the dose of 100 microgram/kg, or less, markedly increased the amount of total sleep (co...
86,429
[ -0.04592703, -0.2740515, -0.1504317, -0.1482792, 0.3984688, -0.2864898, -0.2558002, -0.4979174, -0.2782357, -0.1212218, 0.1947122, -0.05143056, -0.01013725, 0.1755648, -0.2666622, -0.09387783, -0.7030185, 0.02275499, 0.4238284, -0.1953149, -0.2351877, 0.05257436, 0.068733...
Automatic analysis of interictal epileptic activity related to its morphological aspects.
The objectives of this paper are to describe: (i) an algorithm, conventionally called TD (transient discriminator) which allows morphological discrimination among different EEG transients, and (ii) an automated methodology, based upon the proposed algorithm. The completely automated analysis performed by this method ca...
86,432
[ -0.08016808, 0.3523429, -0.07387212, -0.04070038, 0.1241244, -0.5520092, -0.203629, -0.4023164, 0.2158424, -0.1027571, -0.07039274, -0.001909376, -0.1759709, -0.1315582, -0.5118093, -0.0754457, -0.3945353, 0.1309196, 0.2256212, 0.06675375, -0.08583809, 0.1005815, -0.09317...
Effects of ouabain on insulin release, adenosine 3',5'-monophosphate and guanine 3',5'-monophosphate in pancreatic islets.
Isolated pancreatic islets of noninbred ob/ob mice were used to test the hypothesis that adenylate cyclase responds to changes of the transmembrane milieu or electric field in intact beta-cells. In the presence of a phosphodiesterase inhibitor, ouabainstimulated both the release of insulin and the islet content of cAMP...
86,435
[ -0.2232949, -0.1095416, -0.3961188, 0.1154416, 0.2027933, -0.001562143, 0.1811638, 0.06298552, 0.1315088, 0.1402603, 0.01787396, -0.03016707, -0.06862079, -0.06657438, -0.5261964, -0.08149633, -0.4154954, 0.1989982, -0.0960722, 0.02423779, 0.3876463, -0.07468148, 0.100956...
Normal immunosuppressive protein inhibition of human and murine lymphoblastoid cell line proliferation.
Normal immunosuppressive protein, prepared from human plasma by DEAE-cellulose chromatography, inhibits DNA synthesis in human cell lines of lymphocytes of both T and B origin. It also inhibits [3H]thymidine incorporation in mouse cell lines. Normal immunosuppressive protein was able to inhibit the proliferation of the...
86,450
[ -0.1956705, -0.07041961, -0.1563659, -0.2044566, 0.4278666, 0.007023354, -0.2192146, 0.1831882, 0.1514211, 0.08764771, -0.1117449, 0.04071267, 0.1051854, 0.2043717, -0.5365193, 0.1012665, -0.2565381, -0.1135115, -0.1273278, 0.4821225, 0.1007229, 0.1067211, -0.1568446, 0...
A comparative study of the efficiency of hydroxyprogesterone caproate and of chlormadinone acetate in the prevention of premature labor.
The efficacy of caproate of hydroxyprogesterone and acetate of chlormadinone in preventing premature labore was compared in a controlled trial. The survey was based on 211 pregnant women with a high risk of premature delivery discovered during clinical examination. There are no significant differences between the two g...
86,468
[ 0.001195524, 0.1382478, -0.07590127, 0.2179998, -0.09965079, -0.08042422, -0.2925891, -0.2731619, 0.1801063, 0.1121813, 0.06611645, 0.05552499, 0.2472273, 0.2143763, -0.09931719, -0.1935375, -0.1423385, 0.06631043, -0.2067591, 0.2148697, 0.4345168, 0.2846681, 0.06155121, ...
Liver-specific and shared cell membrane antigens. Studies by light- and electron microscopy.
Liver-specific and shared saline-insoluble cell surface antigens were localized by immunofluorescence as well as by light- and electron microscopic immunoenzyme techniques. Antisera against purified mouse liver cell membranes were surface membrane but not organ-specific. Variable quantities of shared antigens were pres...
86,503
[ 0.1311758, -0.1938364, -0.2180694, 0.02869471, 0.03192433, -0.2369705, -0.3562348, 0.09150609, 0.1216118, 0.1127205, 0.1093382, -0.1420943, 0.2480095, -0.1243166, -0.3467735, -0.008532188, -0.6007474, 0.02032815, -0.1924419, 0.376072, 0.1605518, -0.02707442, -0.0420419, ...
Regulatory mechanism of autoantibody production in mice to bromelin-treated isologous red blood cells.
In the spleen of mice immunized with bromelin treated rat red blood cells (RBC), the number of PFC against bromelin treated isologous RBC increased, although immunization with non-treated rat RBC or bromelin treated isologous RBC gave no increase in number of these PFC. This immune response was found to be T-independen...
86,507
[ -0.07118958, 0.02569554, -0.2415667, -0.1092262, 0.3538411, -0.1278073, -0.002978952, -0.07364758, -0.1349664, 0.1506389, -0.04910104, 0.4216746, 0.2926069, -0.006079488, -0.3003016, 0.05636716, -0.1830385, -0.05002679, 0.3928365, 0.2386275, -0.2005225, 0.01236412, 0.0636...
Immunogenetics of the McB1 macroglobulin allotype in cattle.
The paper describes a cattle serum antigen (McB1) which is controlled by a dominant gene (McB1), independent from those controlling the two macroglobulin markers McA1 and McA2 as well as from that controlling the low-density lipoprotein marker Ld1A1. McB1 is located on a high-molecular-weight serum protein which, very ...
86,518
[ -0.1251084, -0.07566303, -0.1347303, -0.3514023, -0.1075141, -0.2467087, -0.334523, 0.1226332, -0.1830795, 0.0446509, 0.1903326, 0.3667502, 0.1333714, -0.0129943, -0.1670581, -0.04894384, -0.2188226, -0.248786, 0.2257606, -0.0390347, 0.2103264, 0.1339616, -0.1323511, -0...
Moloney lymphoma cells express a polyprotein containing the GAG gene-coded p15 and the Moloney leukemia virus-induced cell surface antigen (MCSA).
The relationship between MCSA and the viral structural proteins in YAC Moloney lymphoma cells was further investigated by using membrane immunofluorescence and immunoadsorbent columns. As previously observed, MCSA showed only minimal capping and thereby differed in behaviour from gp70, p30 and p12 virion antigens. Wher...
86,525
[ 0.08214024, 0.03814871, -0.2907575, -0.208009, 0.01744507, 0.2327849, -0.1081894, 0.09537397, -0.03330583, 0.3557088, 0.01247276, 0.1404133, 0.03915116, 0.1785565, -0.5048895, 0.1638463, 0.2714099, -0.1299384, 0.1128225, 0.2020014, 0.4296065, 0.0136425, -0.0648853, 0.10...
Lysogenic pneumococci and their bacteriophages.
About half of pneumococci recovered from pediatric patients and one-third of isolates from adult patients yielded bacteriophages active against one or more of four noncapsulated indicator strains of pneumococcus. Strains of capsular types most frequently causing pediatric infections were associated with lysogeny. Class...
86,538
[ 0.06231827, 0.03595227, -0.0815115, -0.04288242, -0.2451113, -0.2044903, -0.3481148, -0.01865004, 0.02279114, 0.00764454, 0.01348138, 0.1361826, -0.122731, -0.1486016, -0.1853081, 0.2191465, -0.1127333, 0.1494306, 0.06708106, -0.04761754, 0.2848929, -0.123425, -0.193006, ...
Cytomorphologic results of preparation experiments for monolayer deposition of cervical material.
For automated prescreening methods by high resolution analysis serving as a detecting method in gynecologic mass screening programs a new monolayer deposition method of cervical material has been used. This method will be outlines briefly and the mode of evaluation as well as current cytomorphological findings will be ...
86,561
[ -0.07695724, 0.1915837, -0.1135899, 0.009639399, 0.09097653, -0.197517, -0.2260414, 0.1333764, 0.5003696, 0.2156559, 0.008996692, -0.1391004, 0.0412649, 0.03804386, -0.3586406, 0.05207239, -0.09468, 0.06324952, -0.09532472, 0.1780164, 0.5589435, 0.1887826, -0.108515, 0....
Ultrastructure of Bacteroides species: Bacteroides asaccharolyticus, Bacteroides fragilis, Bacteroides melaninogenicus subspecies melaninogenicus, and B. melaninogenicus subspecies intermedius.
Representative strains of two subspecies of Bacteroides melaninogenicus (subspecies melaninogenicus and subspecies intermedius) and Bacteroides asaccharolyticus as well as B. asaccharolyticus strain 536B isolated from a human perirectal abscess and Bacteroides fragilis ATCC 25285 were examined by glutaraldehyde-osmium ...
86,590
[ -0.01333647, -0.140514, -0.0210258, 0.3059513, -0.3112973, -0.2804254, 0.3667586, 0.1259063, 0.06718675, 0.178492, -0.2541775, 0.09299401, -0.3504578, -0.2234533, -0.6129523, 0.02773011, -0.5144136, -0.1639784, -0.2850462, 0.1850371, 0.1334884, 0.2723204, 0.05918382, 0....
Haemangiopericytoma in otolaryngology.
Haemangiopericytoma is a rare vascular tumour with variable pathological behaviour. It arises from the proliferation of special cells called 'pericytes' which are found outside the blood capillaries. There is no specific predilection for any site in the body. Clinically and histologically, it can be benign or malignant...
86,592
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