title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Flow cytometric DNA analysis in fine needle aspiration biopsies from patients with prostatic lesions. Diagnostic value and relation to clinical stages. | Transrectal fine needle aspiration biopsy was carried out in 59 patients with cancer of the prostate, benign prostatic hypertrophy and prostatis for cytomorphological examination and flow cytometric DNA analysis. One major single peak in the DNA histogram was observed in patients with benign hyperplasia, prostatitis an... | 82,369 | [
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Serum haptoglobulin changes in patients with severe isolated head injury. | From a series of 74 patients with severe head injuries and massive brain lesions, we measured the changes in haptoglobulin in 33 cases. On average, the globulin was, after a short drop in the first two days, increased about three times towards the seventh day, and was still above normal after ten days. Seen together wi... | 82,376 | [
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Genetic control of the immune response to insulin: its dependence upon a macrophage mediated selection of distinct antigenic sites. | The immune response to insulin, in both mouse and guinea pig , is under control of H-linked immune response genes. When immunized with either pork or beef insulin to CFA, both strain 2 and 13 guinea pigs respond by antigen-specific lymphocyte proliferation and synthesis of specific antibody. The specificity of the elic... | 82,390 | [
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Cultured Plasmodium falciparum used as antigen in a malaria indirect fluorescent antibody test. | Human sera obtained from persons infected with Plasmodium falciparum were tested by a standard indirect fluorescent antibody (IFA) technique using antigen obtained from long term in vitro cultures of two strains of P. falciparum, and antibody in high titer was reproducibly detected. Sera from uninfected persons had und... | 82,407 | [
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Palliative dilation for dysphagia in esophageal carcinoma. | We retrospectively reviewed our experience with palliative dilation for dysphagia in esophageal carcinoma. During a 3-year period 26 patients with squamous-cell carcinoma of the esophagus underwent peroral esophageal dilation for relief of dysphagia. Twenty-four were able to resume a soft or regular diet after dilation... | 82,417 | [
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Differential staining of collagens type I, II and III by Sirius Red and polarization microscopy. | Organs of fish, amphibian, reptile, bird and mammals when stained by Sirius Red and studied with polarization microscopy present different colors in regions where collagens I, II and III have been described. Collagen type I presented a yellow, orange or red color while collagen type III appeared green. Collagen type II... | 82,432 | [
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Central spherules in pulmonary corpora amylacea. | Pulmonary corpora amylacea were found in 37 of 6,500 (0.6%) unselected autopsies. The patients had ranged in age from 48 to 87 years (average, 70). Among 1,000 corpora amylacea studied, there were 30 that contained centrally located, more or less intact, hollow spheres 15 to 20 mu in diameter. Morphologic consideration... | 82,433 | [
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Parathyroid identification by methylene blue infusion. | A preoperative infusion of methylene blue was employed in 20 patients undergoing neck exploration for hyperparathyroidism. The dye was noted to stain adenomas and hyperplastic glands a deep purple-blue colour. Normal parathyroid tissue stained to a lesser extent or not at all. All unstained parathyroid tissue was norma... | 82,440 | [
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5-azacytidine in acute leukemia. | 101 patients with acute leukemia in relapse were treated with 5-azacytidine according to three schedules: Regimen A--300 mg/m2(day divided intravenously at 8 hour intervals for 5 days; Regimen B--750 mg/m2 as a single iv pulse dose administered at 2 to 3 weeks intervals; and Regimen C--300 mg/m2/day by continuous infus... | 82,472 | [
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Polystyrene tube immunoradiometric assay for human alpha1-fetoprotein, and its use for mass screening. | We describe a two-site immunoradiometric assay for human alpha1-fetoprotein, with use of antibody-coated polystyrene tubes as solid phase. The sensitivity, precision, and simplicity of this system make it eminently suitable for mass-screening purposes. We currently use it for neonatal detection of hereditary tyrosinemi... | 82,493 | [
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Activation of latent collagenase of human leukocytes and gingival fluid by bacterial plaque. | Collagenase activity was studied in human leukocytes, gingival crevicular fluid and bacterial plaque, with soluble radioactive collagen as substrate. Inflamed gingiva liberated vertebrate type collagenase into the crevicular fluid in active form. Healthy gingiva, in contrast, released collagenase in a latent form that ... | 82,562 | [
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Expression of I-A and I-E,C region-coded Ia antigens on functional B cell subpopulations. | Ia antigens from specific subregions have been examined on functional B cell populations. Expression of both I-A and I-E,C region antigens was demonstrated on cells required for both lipopolysaccharide mitogenesis and polyclonal activation. Similar I-A and I-E,C subregion expression was found on cells required for resp... | 82,583 | [
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Purification of alpha-2 macroglobulin by immunoadsorbent chromatography. | A method for preparation of alpha-2 macroglobulin (alpha2M) by immunoadsorbent chromatography utilizing rabbit--anti-human alpha2M-conjugated Sepharose 4B is described. This procedure offers a rapid, simple and inexpensive method for purification of alpha2M from as little as 2.0 ml of human serum. By multiple applicati... | 82,589 | [
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Electrophoresis of immunoglobulin G. Facilitated migration of minute amounts in agarose. | Migration of very small amounts of immunoglobulin (20 ng) is restricted in agarose electrophoresis. Incorporation of a stable protein matrix (rabbit gamma globulin 1 mg/ml) in the agarose permits unrestricted migration so that immunoelectrophoresis of this quantity of radiolabelled antibody is possible. Very small amou... | 82,591 | [
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Idiotypic cross-reactivity between antibodies of different specificities. | Cross-idiotypic specificity has been demonstrated between antibody populations of different specificities using antibodies directed toward human sickle cell hemoglobin (HbS). A site-specific antibody directed toward the beta6-position of HbS, anti-Val, was used to elicit an anti-idiotypic response in rabbits. Using thi... | 82,603 | [
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Involvement of H-2L gene products in virus-immune T-cell recognition. Evidence for an H-2L-restricted T-cell response. | The H-2L locus is closely linked to H-2D and codes for antigenic specificities present on a 45,000 mol wt glycoprotein that is distinct from the molecule which bears the D region private specificity. It was found that BALB/c-H-2db mice, which lack detectable cell-surface H-2L gene products, were able to generate influe... | 82,606 | [
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Corpora amylacea in mesothelioma of the atrioventricular node. | Rounded or polyhedral, acellular, dense lamellated structures were seen within gland-like spaces in a case of atrioventricular mesothelioma. These structures exhibited many of the histochemical characteristics of amyloid, viz., pink colour with green birefringence and bright red fluorescence with alkaline Congo red; or... | 82,614 | [
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Very long-term treatment of peptic ulcer with cimetidine. | In an open trial, 96 patients with endoscopically proven peptic ulcers were randomly allocated to treatment with cimetidine (1 g/day) for periods of 3, 6, 9, or 12 months. After their courses of treatment, the patients were followed up for at least 6 months. In 92% the ulcers had healed after treatment for 1 month, and... | 82,680 | [
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Hepatitis B and primary hepatocellular carcinoma in a European population. | The prevalence of serological markers of active of past hepatitis-B virus (H.B.V.) infection was determined in 80 Greek patients with primary hepatocellular carcinoma (P.H.C.), 160 age and sex matched controls and 40 patients with metastatic liver cancer (M.L.C.). The relative risk of the various patterns of H.B.V. ser... | 82,732 | [
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Autoantibodies to parathyroid hormone receptor. | Autoantibodies which block the binding of parathyroid hormone to membrane receptors for the hormone were detected in the sera (especially in the IgG fraction) of 49 out of 50 uraemic patients with secondary hyperparathyroidism (patients with high levels of C-regional parathyroid hormone). These antibodies are species-s... | 82,734 | [
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Effect of myo-inositol on peripheral-nerve function in diabetes. | myo-Inositol, 500 mg twice a day, given to seven diabetic patients for two weeks, increased the amplitude of the evoked action potentials of the median, sural, and popliteal nerves by an average of 76%, 160%, and 40%, respectively. There was no significant change in the conduction velocities of these nerves, myo-Inosit... | 82,784 | [
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Alpha2-plasmin-inhibitor deficiency (Miyasato disease). | A 25-year-old man, born in Okinawa, Japan, had a haemorrhagic diathesis characterised by prolonged bleeding and ecchymoses after minor trauma and spontaneous joint haemorrhage. The frequency and severity of these episodes were reduced by an antiplasminic drug. Routine coagulation studies revealed no abnormalities excep... | 82,839 | [
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Reciprocating tachycardia due to a right-sided unidirectional retrograde anomalous pathway (URAP). | An 8 year-old boy had extensive electrophysiological evaluation of his recurrent supraventricular tachycardias. His ECG never showed delta waves but intracardiac stimulation and recording disclosed the following (1) eccentric retrograde atrial activation; (2) increased cycle length and retrograde conduction time follow... | 82,948 | [
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Pacemaker surveillance "à la francaise": an attempt to detect faulty series of permanent pacemakers at an early stage. | Until the present, implantable pacemakers have not been subject to government regulation in France, as it had been feared that unreasonable controls would interfere with the development of this new form of therapy. Physicians were left to choose what seemed the most reliable device, and patients benefitted immediately ... | 82,952 | [
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Enhancement of banding patterns in human metaphase chromosomes by energy transfer. | Intermolecular energy transfer between appropriately chosen pairs of dyes can be used to induce or enhance banding patterns in human metaphase chromosomes. Energy transfer, calibrated by fluorometric studies on soluble dye.DNA complexes, can also be detected by photometric measurements on cytological preparations of me... | 82,970 | [
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Lymphoblastoid cell lines from patients with chronic lymphocytic leukemia: identification of tumor origin by idiotypic analysis. | Multiple lymphoblastoid cell lines have been derived from two patients with chronic lymphocytic leukemia with an associated monoclonal immunoglobulin (Ig) band. Idiotypic antisera raised against the monoclonal serum Ig bands were shown to be specific for the membrane Ig of the patients' leukemic cells. The idiotypic de... | 82,971 | [
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Gluten-sensitive enteropathy: genetic analysis and organ culture study in 35 families. | The genetic marker histocompatibility antigen HLA-B8 is present in 80% of patients with gluten-sensitive enteropathy (GSE). We studied 35 families with at least one affected member to determine whether an HLA-region gene alone could determine susceptibility to GSE. The incidence of HLA-B8 in the patients was 69% vs 22%... | 82,994 | [
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The operation of immunological networks in Graves' disease. | Association between Graves' disease and HLA--B8 has been previously documented, as have been associations between 1 gG heavy chain allotype markers (Gm). We found a significant increase in the phenotype fnb/fb (ie. positivity for fb) in patients with Graves' disease compared to controls, raising the possibility of allo... | 83,018 | [
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0.1061223,
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0.1732496,
0.06839778,
-0.3463749,
-0.04861651,
-0.3955536,
-0.06994063,
0.1912446,
0.2040483,
0.4019074,
0.2216623,
0.4843777,
-0.3029405,
-... |
Eperythrozoon ovis. I. Serological diagnosis of infection by the indirect immunoflurescent antibody test. | The indirect immunofluorescent antibody test (IFAT) was evaluated for the detection of Eperythrozoon ovis infection in sheep. The test first became positive, on the average, 10 days following exposure to E. ovis and remained positive for 24 months, the longest period checked. Reciprocal titres in the first three days a... | 83,044 | [
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0.3730854,
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0.... |
[Monitoring the effectiveness of conservative treatment of benign prostatic hypertrophy by means of uroflowmetry]. | 96 patients with benign hyperplasia of the prostate and dysuric complaints in stage I and beginning stage II were treated conservatively and medicamentously up to 12 months. In the collective of patients subdivided into 4 groups the conservative therapy was carried out in 3 groups with different phyto-preparations and ... | 83,057 | [
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0.4079368,
0.2451492,
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-0... |
[Relationship between the dynamics of mental disorders in patients with primary hypogonadism and surgical intervention (testicular transplantation)]. | Clinico-catamnestical, experimental-psychological and EEG studies were made of 60 patients with primary hypogonadism. Variants of protracted pathological reactions to the disease and pathological personality development are described. The studies indicate an intercorrelation of the dynamics of mental disorders and the ... | 83,064 | [
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0.2410424,
0.1842555,
0.1008197,
-0.1132... |
Failure of transfer factor therapy in atopic dermatitis. | A controlled clinical study was conducted on 6 patients with atopic dermatitis to assess the efficacy of transfer factor. After the code was broken the 3 patients treated with placebo preparation were treated with transfer factor for a further period of 10 weeks. No definite therapeutic effects could be demonstrated. T... | 83,072 | [
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0.3129933,
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0.01698246,
-0.03... |
Distribution of complement and immunoglobulin in oral pemphigus lesions. | The present report describes four cases of oral pemphigus vulgaris lesions in which complement, in contrast to the situation as reported for skin, was found only in the basal and parabasal layer, whereas IgG was present in all layers of the epithelium. | 83,081 | [
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0.3277429,
0.4111861,
0.018617... |
Treatment of acne vulgaris with topically applied erythromycin and tretinoin. | A twice daily application of 2% erythromycin base in hydroalcoholic solution accompanied by once daily use of 0.05% tretinoin (retinoic acid) solution was substantially more effective than tretinoin or erythromycin alone for treatment of inflammatory acne of moderate severity. Therapeutic enhancement by this combinatio... | 83,088 | [
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0.008957883,
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0.01154587,
0.06342763,
0.1187699,... |
Residual nitrous oxide in operating room personnel. | The concentrations of nitrous oxide in the blood and end-tidal air of 10 operating-room nurses were assayed by gas chromatography immediately and 1, 2, 5, and 21 h after 3 hours of exposure to an average of 380 ppm of nitrous oxide in operating-room air. In the second trial the nurses' end-tidal air concentrations of n... | 83,091 | [
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0.2349311,
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0.5042201,
0.1577273,... |
Immuno-histochemical localization of cyclic nucleotides in the periodontium: mechanically-stressed cells in vivo. | Cyclic AMP and cyclic GMP, considered to be cell proliferation regulators, have been reported to fluctuate in proliferating fibroblasts in vitro. The objectives of this experiment were to study the localization, distribution and staining patterns of these cyclic nucleotides in mechanically-stressed, proliferating perio... | 83,116 | [
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Mesencephalotomy for intractable pain due to malignant disease. | 40 mesencephalotomies were carried out on 38 patients with intractable pain secondary to malignant disease. In 2 patients with bilateral pain, a bilateral mesencephalotomy was required. Most of the patients had pain in the head, neck or upper trunk secondary to carcinoma of the nasopharynx, jaw, tongue, or neck. | 83,121 | [
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[Morphological virus diagnosis--electron microscopy study of animal viruses with negative contrast procedure]. | Reported in this paper are results obtained in morphological virus diagnosis by using the negative contrast technique on the basis of electron microscopy. The availability of high-efficiency electron microscopy as well as of perfectly improved techniques of preparation, knowledge of the latest virus model concepts, and... | 83,124 | [
-0.1988244,
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... |
[The effect of pesticide combinations on laboratory rats. II. Modification of selected hematological parameters and blood glucose]. | Reference is made to the first communication made under this heading. The haematological parameters did not undergo any visible change in response to the chosen experimental arrangement. Further studies should be undertaken, with the view to elucidating the possibility of bone marrow change. The blood glucose levels we... | 83,127 | [
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0.000237862... |
A clinical analysis of pseudopapilledema. II. Visual field defects. | Goldmann perimetry was performed on patients with pseudopapilledema. The cases were subdivided into those with ophthalmoscopically visible hyaline bodies (HB), (group 1) and those without (group 2). In group 1, 37 of 52 eyes (71%) demonstrated field abnormalities, including enlargement of the blind spot (68%) and vario... | 83,136 | [
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0.008102069,
0.2053296... |
Subcellular and polypeptide distributions of slowly transported proteins in the garfish olfactory nerve. | In the garfish olfactory nerve proteins labeled with [3H]leucine are transported by slow axonal flow as a well-defined crest of radioactivity. At 21 degrees C slow flow moves along the axon with a velocity of 0.92 +/- 0.02 mm/day. It has been possible to analyze 4 subcellular fractions (soluble, mitochondrial and 2 mem... | 83,181 | [
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0.1242378,
... |
Preliminary characterization in mice of the effect of isoprinosine on the immune system. | A preliminary characterization of the immunomodulatory activity of isoprinosine in mice was conducted in both normal and tumor-bearing mice. Under the experimental conditions employed, isoprinosine given ip and orally was found to possess some immunomodulatory capacity in various model systems. The compound appeared t... | 83,191 | [
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0.02031172,
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An avian oncovirus mutant (SE 21Q1b) deficient in genomic RNA: biological and biochemical characterization. | We have isolated a nonconditional mutant of PR-RSV-E with unique properties. This virus (SE 21Q1b) is shed from a continuously growing culture of transformed quail cells. 21Q1b virions are unable to transform or replicate in other quail or chicken cells after exogenous infection, despite the fact that the viral particl... | 83,199 | [
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Techniques and therapies for primary and metastatic liver cancer. | In summary, of the 460 patients of primary carcinoma of the liver admitted to the University Surgical Unit at the Queen Mary Hospital over a period of 12 years, more than 40% could not be treated, and only 91 of the patients were candidates for curative resection. The cure rate is very small; a 1- to 2-year survival wa... | 83,219 | [
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0.4472302,
0.2502947,
... |
Interaction between barium, strontium and calcium in histamine release by compound 48/80. | Pre-incubating rat peritoneal and pleural mast cells for 30 min at 2 degrees C in Ca2+-free Tyrode containing Ba2+ (30 mM) markedly reduced histamine release by compound 48/80 (0.5 microgram/ml). Evoked secretion was not significantly altered by pre-incubation with Sr2+ (30 mM) at this temperature whilst Mg2+ (30 mM) a... | 83,238 | [
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0.3809005,
0.1710724,
0.3841041,
0.1868134,... |
Nigrothalamic pathway in the cat demonstrated by autoradiography and electron microscopy. | Light microscopic autoradiography and electron microscopy were used to trace the nigrothalamic projections and to study the sites of termination of this pathway in the cat. Injections of tritiated amino acids or electrolytic lesions were placed in the substantia nigra pars reticularis (SNr). An accumulation of radioact... | 83,240 | [
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0.3256649,
0.2067958,
0.29147... |
Identification of the projection from the visual cortex to the claustrum by anterograde axonal transport in the cat. | Visual cortex, including areas 17, 18, and sometimes 19, was injected with tritiated leucine. Terminal labelling could be detected by autoradiography in the dorsocaudal part of the ipsilateral claustrum in all cases. | 83,241 | [
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Specificities of heterologous antisera against human leukaemia cells. 2. Reactions against fetal liver cells and absorption studies with fetal tissue. | Rabbit or goat antisera directed to ALL and AML cells were investigated in cytotoxicity tests with fetal liver cells as targets. After absorption with erythrocytes and spleen cells from allogenic donors the antisera killed fetal liver cells. There was no reaction with remission leukocytes or blood leukocytes from norma... | 83,266 | [
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Protein cross-match test for the diagnosis and prevention of reactions after the transfusion of blood and cryoprecipitate. | The examination by means of counterimmunoelectrophoresis for protein incompatibility of the serum of 62 patients who developed an allergic or pyretic post-transfusion reaction revealed incompatibility in 23 cases (37.2%). It was due to the presence of antibodies in 8 recipients (34.8%) and in 15 blood donors (65.2%). T... | 83,277 | [
-0.07722075,
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0.1410124,
-0.2062029... |
Demonstration of shared and unique immunological determinants in enterotoxins from Vibrio cholerae and Escherichia coli. | Immunodiffusion and biological neutralization studies demonstrated that the heat-labile enterotoxin (LT) from Escherichia coli has antigenic determinants in common with each of the isolated subunits (A and B) of the enterotoxin (choleragen) from Vibrio cholerae. Each of the enterotoxins also possesses unique antigenic ... | 83,301 | [
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Graphic representation of the distribution of acetylcholinesterase in cat dorsal root ganglion neurons. | Acetylcholinesterase (AChE) activity of primary sensory neurons of the cat has been quantitated and correlated with cell size. Dorsal root ganglia of the fourth and fifth thoracic spinal levels were studied. Frozen longitudinal and cross-sections were collected serially and stained with Cresyl Violet for total cell cou... | 83,316 | [
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0.01359764,
0.02... |
Location of taste buds in intact taste papillae by a selective staining method. | Taste buds were found to stain strongly and selectively in intact papillae with highly acidic dyes such as ponceau S. In intact tongues the taste buds in the fungiform, circumvallate and foliate papillae of the cynomolgus monkey and in the fungiform papillae of the rat as well as the taste discs in the fungiform papill... | 83,317 | [
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0.09232156,
0.007126268... |
Striated myofibrils in anti-myosin stained, isolated chicken gizzard smooth muscle cells. | Highly purified chicken gizzard myosin was used to induce antibody production in rabbits. The IgG fraction was separated from the antisera and coupled to fluorescein isothiocyanate (FITC). Specific antibody (AGM) was isolated from the IgG fraction by affinity purification. Comparisons of the specificity of IgG and AGM ... | 83,318 | [
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... |
Plasminogen activator synthesis by cultured human embryonic lung cells: characterization of the suppressive effect of corticosteroids. | The synthesis of plasminogen activator (PA) by cultured human embryonic lung (HuEL) cells has been examined. The production of PA by these cells was found to be reversibly inhibited by physiological levels of glucocorticoids. The suppression of PA synthesis in HuEL cells was not accompanied by an inhibition of cell gro... | 83,324 | [
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0.04325804,
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RNA synthesis by nuclei and nucleoli from ischemic liver cells. | Nuclei and nucleoli were isolated from rat livers subjected to an interruption of the blood supply for periods of different duration, as well as after restoration of the blood supply. They were assayed for RNA synthesis under conditions of diverse ionic strengths, and in the presence of an exogenous template, such as p... | 83,325 | [
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-... |
Atrial specific granules of the rat heart: light microscopic staining and histochemical reactions. | An investigation was carried out to determine general staining and histochemical properties of rat atrial specific granules. It was found that these granules may be demonstrated using aldehyde fuchsin after pretreatments which involve oxidation or thiosulfation. This new way of demonstrating atrial granules is compared... | 83,339 | [
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-0.5336325,
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0.1350959,
0.1944166,
0.04739031,
0.2845344,
-0.1960... |
The tumor-producing effect of automobile exhaust condensate and fractions thereof. Part III: mathematical-statistical evaluation of the test results. | This paper deals with the mathematical-statistical evaluation of experiments devoted to the following problems: 1. To what extent is the carcinogenic potency of automobile exhaust gas condensate dependent on the dose? 2. What fractions (groups of substances) of the automobile exhaust gas condensate are mainly responsib... | 83,349 | [
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[Toxicological studies on pepleomycin sulfate (NK 631). I. Acute toxicity of pepleomycin in mice, rats and dogs (author's transl)]. | Studies on acute toxicities of pepleomycin sulfate were carried out in both sexes of mice and rats, comparing with bleomycin, and male dogs. Pepleomycin was administered subcutaneously, intravenously and intraperitoneally in both sexes of mice and rats, and intravenously in male dogs respectively. Mice and rats, and in... | 83,404 | [
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0.2367253,
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0.3583891,
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[Absorption, excretion, distribution and metabolism of 3H-labelled pepleomycin sulfate (author's transl)]. | Absorption, excretion, distribution and metabolism of pepleomycin sulfate (NK631) were investigated in rats after intravenous administration of 3H-NK631 by whole-body autoradiography, CM-Sephadex column chromatography and high performance liquid chromatography. The highest radioactivity was found in kidney, followed by... | 83,412 | [
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0.3265156,
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Lack of correlation between mesenchymal cell death and morphogenesis after different extents of apical ectodermal ridge/rim ectoderm removal in the chick embryo wing bud. | The removal of the apical ectodermal ridge (A.E.R.) subsequently causes distal deletion defects in the limb. There have been contradictory reports as to the appearance of cell death in the mesenchyme after A.E.R. removal, as well as to its morphogenetic significance. In our study the A.E.R./ rim ectoderm removal was va... | 83,457 | [
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Further studies of the prospective fates of blastomeres at the 32-cell stage of Xenopus laevis embryos. | Each blastomere in the marginal zone of Xenopus laevis embryos at the 32-cell stage was stained with Nile blue sulphate. Only specimens with the typical arrangement of blastomeres of morulae of this species were used, and special care was taken to prevent the dye from spreading to neighbouring cells and to determine th... | 83,458 | [
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0.121382... |
Fetal damage despite low-phenylalanine diet after conception in a phenylketonuric woman. | A woman with phenylketonuria gave birth to an infant with a cardiac defect and microcephaly despite introduction of a low-phenylalanine diet 5 weeks after conception (3 weeks after the first missed period). In maternal phenylketonuria fetal damage leading to reduced brain growth and cardiac malformations probably occur... | 83,464 | [
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0.2692796,
0.0817490... |
Assessment of inactivated influenza-A vaccine after three outbreaks of influenza A at Christ's Hospital. | The boys of Christ's Hospital experienced outbreaks of influenza A in 1972 (A/England/42/72), in 1974 (A/Port Chalmers), and in 1976 (A/Victoria). In each outbreak, the protective effect of inactivated influenza-A vaccine was limited to those boys, not already immune, who were vaccinated for the first time with the mos... | 83,475 | [
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[Principles of radical treatment of soft tissue tumors (author's transl)]. | Malignancy should always be suspected for any soft tissue tumor. Thus, histologic examination of the totally excised growth is mandatory. Amputation is indicated as a curative measure for recurrencies and lesions that cannot be excised locally. It is also indicated for palliation in cases with ulceration, impaired func... | 83,521 | [
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[Prognosis of cardia carcinoma]. | Based on a material of 223 patients treated for cardia carcinoma the surgical problems and the results after palliative, radical and enlarged resection are discussed. In the early stage without nodular involvement (I) in 72% of the radically operated patients a 5-years and 10-years cure could be obtained, in relation t... | 83,559 | [
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Cell surface antigens containing beta2-microglobulin as the common subunit. | beta2-Microglobulin, which was first discovered in various biological fluids, has been shown to be the common subunit of the human HLA-A,B,C antigens. In the mouse beta2-microglobulin is associated with H-2K, D and L antigens and with TL and Qa-2 antigens, beta2-microglobulin and the heavy HLA antigen chains are simila... | 83,566 | [
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0.0... |
[Comparison of serum levels of beta2-microglobulin and carcino-embryonic antigen in the follow-up of lung cancer (author's transl)]. | Serum levels of carcino-embryonic antigen (CEA) and beta2-microglobulin (beta2m) were assayed on 133 sera during follow-up of 31 patients with lung carcinoma (squamous cell ca. without recurrence : 2, squamous cell ca. with recurrence : 11, anaplastic cell ca. : 4, adenocarcinoma : 2, unclassifiable : 5). Normal creati... | 83,584 | [
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-0.0... |
[Serum beta2-microglobulin and carcino-embryonic antigen in cancerous patients. A preliminary study of 258 cases (author's transl)]. | In this preliminary study dealing with beta2-microglobulin (beta2m) levels in the series of 258 patients, two group are considered:--a group of 208 patients with evolutive tumour;--a group of 50 patients with no evolutive tumour. This study shows a significantly higher incidence of cases with elevated levels of carcino... | 83,587 | [
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[Occurrence of beta2-microglobulin in normal and carcinomatous renal tissue (author's transl)]. | Fifty renal tissues and renal tumours are examined and the occurrence of beta2-microglobulin (beta2m) are measured. It is found especially in the solubilized fraction of the tissue. The renal tumours contain four time more beta-2m but they are to be divised into two populations in accordance to their microscopic and ma... | 83,588 | [
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Suppression of demand mechanism by inactive myocardial electrodes. | A 14 year old girl, at age 8, had had a bipolar pulse generator implanted with myocardial leads. Because one of the myocardial leads fractured near the electrode, a second pair of myocardial leads were implanted. Thus, the patient had two pairs of myocardial leads and one demand pulse generator implanted. When the pati... | 83,608 | [
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Evaluation of a rechargeable pacemaker system. | A rechargeable-demand nickel-cadmium pulse generator for permanent transvenous cardiac pacing was evaluated in 66 patients. During a cumulative follow-up period of 2,333 patient months (194.4 patient years), failure of the pacing circuit occurred in 3 patients at 21, 25, and 27 months, respectively. Nine patients had d... | 83,632 | [
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0.2277389,
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Partial pacemaker recycling of implanted QRS-inhibited pulse generators. | In the evaluation of twenty-three patients with implanted QRS-inhibited lithium-powered pulse generators (Intermedics C-MOS-1 and ARCO L1-2D), we repeatedly observed the phenomenon of partial pacemaker recycling (PPR), in which the escape interval induced by a premature ventricular beat is shorter than the automatic in... | 83,633 | [
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... |
Fc receptor bearing 'hairy cells' of leukaemic reticuloendotheliosis bind soluble antigen--antibody complexes and adhere to immobilized complexes, but fail to mediate antibody dependent cellular cytotoxicity. | The majority of hairy cells from three patients with leukaemic reticuloendotheliosis were adherent cells bearing surface immunoglobulin, complement receptors, and Fc receptors. Highly purified populations of malignant hairy cells, which readily bound soluble antigen-antibody complexes in suspension and were able to adh... | 83,669 | [
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0.08... |
Radioimmunoassay of the insulin receptor: a new probe of receptor structure and function. | A sensitive and specific radioimmunoassay for the insulin receptor has been developed employing receptor autoantibodies from the serum of a patient with insulin-resistant diabetes. The assay detects insulin binding sites at concentrations as low as 0.1 nanomolar; distinguishes between receptors originating from human p... | 83,675 | [
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[Efficacy of the use of combinations of teaching aids in propaedeutics education]. | Audio-visual and printed teaching and learning aids are used for the instruction in the subject of "propaedeutics of prosthetic stomatology". The achievements and the time required for the guidance and supervision of the students were evaluated. Furthermore, the use of the teaching and learning aids by the students was... | 83,697 | [
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... |
A complex of HLA-D specificities detected by HTC typing: Dw7, Dw11, and TMo. | Homozygous typing cells defining HLA-D antigens related to Dw7 appear to identify a complex of partially overlapping structures. The relationships between these specificities were analyzed using 7th Workshop cells and other cells sent to the reference laboratory. The local cells JLe and KA seem to fit the antigen Dw11,... | 83,707 | [
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... |
The formation of phenylethane-1,2-diol 2-acetate in the metabolism of styrene oxide by rabbit liver microsomes in vitro. | 1. Phenylethane-1,2-diol 2-acetate has been isolated from the incubation of styrene oxide or styrene diol with liver microsomes of phenobarbital-pretreated rabbits. 2. Observed ratios of phenylethane-1,2-diol to its 2-acetate in the incubation mixtures ranged between 19 : 1 and 5 : 1 with different microsomal preparati... | 83,739 | [
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-... |
[Mass media. Prevention and the media]. | Though the information communicated by the media is important in so far as it wakes and upholds the interest of the population on a subject such as preventive medicine, it is not sufficient to change the behaviour of this population. The real reasons why opinion shows too much indifference towards preventive medicine s... | 83,745 | [
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0... |
Histochemical fibre types in human extraocular muscles, an investigation of inferior oblique muscle. | In order to test histochemical fibre types in human extraocular muscles, 2000 fibres from 5 inferior oblique muscles were examined in serial sections for myosin ATP-ase following preincubation at pH 4.3, menadione-linked alpha-GPD and NADHTR activity. In ATP-ase 4.3, +/- 15% of fibres in central and peripheral areas st... | 83,777 | [
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0.... |
Diurnal rhythmicity in folic acid metabolism of rat liver and kidney. | In rat liver and kidney, tetrahydrofolate formylase activities show diurnal rhythms with maxima in the middle of the dark phase. The rhythms are not generated by de novo synthesis of enzyme protein. Dihydrofolate reductase activity is arrhythmic in both liver and kidney. | 83,823 | [
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[Role of duodenal serotonin in the pharmacological effects of DOPA and dopamine in the isolated rat duodenum]. | We have studied the responsibility of tissue serotonin reserves in the excito-motor effects induced by DOPA and dopamine on the isolated rat duodenum in vitro in certain experimental conditions. Two groups of experiments have been performed: first the determination of serotonin endogenous stores after administration of... | 83,826 | [
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0.4546574,
0.1387922,
0.08547249,
-0.05340... |
A comparison of maternal serum levels of alpha-fetoprotein in normal and pre-eclamptic pregnancies. | Alpha-fetoprotein (AFP) concentrations were measured by radioimmunoassay in serum from women with normal and pre-eclamptic pregnancies. An analysis of the results obtained in normal pregnancy was made using arithmetic and semi-logarithmic scales, and a statistical conversion of the AFP values in relation to gestational... | 83,874 | [
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0.07024086,
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... |
Demonstration of tube leukocyte adherence inhibition assay with coded samples of blood. | Heparinized samples of blood from three different patients were coded by impartial observers. The buffy coat leukocytes from the coded samples of blood were isolated and incubated separately with extracts of colon and pancreatic cancer in the tube leukocyte adherence inhibition assay. At the completion of the assay, th... | 83,917 | [
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-0.2674522,
-0.2404801,
-0.1185619,
0.2915031,
0.4222443,
-0.01965942,
-0.08295514,... |
Induction of high frequencies of endoreduplication in mammalian cell cultures with 33258 Hoechst and rubidazone. | Cells of the mouse L strain and the Chinese hamster CHO line were treated with 33258 Hoechst, rubidazone, and a combination of these. Recovering cell populations following the drug removal exhibited a high frequency (20--50%) of metaphases with diplochromosomes (endoreduplication), especially in the combination treatme... | 83,930 | [
0.07060582,
-0.2742045,
0.07567595,
0.07008265,
0.2615432,
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-0.07562976,
-0.1991009,
0.4699593,
-0.05246037,
-0.01497289,
0.06566329,
0.02101966,
0.3768029,
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-0.4653886,
-0.1181508,
-0.1011731,
0.2270904,
0.3830206,
0.2765684,
-0.08686534... |
Comparison of the karyotypes of four Cercopithecoidae: Papio papio, P. anubis, Macaca mulatta, and M. fascicularis. | The karyotypes of two species of baboons, Papio papio and P. anubis, and of two species of Macaca, M. mulatta and M. fascicularis, are compared after the use of numerous banding techniques. No difference was detected between the karyotype of the two Papio species. However, a minor change in the T-staining of a short se... | 83,931 | [
0.07045379,
0.2928457,
0.1291395,
-0.1737453,
0.1349808,
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-0.01060698,
-0.1001013,
0.09643263,
0.1836249,
0.2066419,
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0.02828939,
-0.01749853,
-0.4641845,
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-0.2616224,
-0.01843872,
0.03523148,
-0.06483348,
0.3062408,
0.2500696,
-0.0913343... |
Reassessment of presumed Y/22 and Y/15 translocations in man using a new technique. | A new chromosome banding technique, distamycin A plus DAPI, has been used to reexamine cases of presumed Y/autosome translocations. In contrast with the results obtained with quinacrine fluorescence (Q-banding), the satellites of acrocentric chromosomes do not fluoresce brightly with this new (DA-DAPI) method, making i... | 83,932 | [
-0.4194103,
0.1646305,
0.1294244,
0.078416,
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-0.2413987,
0.2182921,
0.223107,
0.01845874,
0.1627321,
0.1633029,
0.2985653,
0.1070559,
-0.5904144,
-0.2970403,
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-0.04115811,
-0.1420697,
-0.2477491,
0.469164,
0.04797598,
-0.2518,
-0.135778... |
Searching for euthanatos: the hospice alternative. | American culture, with its insistence on happiness and its obsession with technology, discourages a realistic approach to death. Within the concept of Euthanatos, a "good death," however, patients get the chance in the comfortable surroundings of the hospice to integrate dying into their total life experience. Here, th... | 83,957 | [
-0.2570641,
-0.1574385,
0.02178719,
0.07819323,
0.04829112,
-0.006656654,
-0.152603,
-0.08277529,
-0.1012096,
-0.557003,
0.04691536,
0.05378473,
-0.06712539,
-0.1026734,
-0.2729151,
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-0.4716242,
-0.04776715,
0.1357711,
-0.02684509,
-0.1245573,
0.2325202,
-0.2... |
Cell mediated immunity to human myelin basic protein in Vogt-Koyahagi-Harada syndrome. | An immunological basis for neurological involvement in Vogt-Koyanagi-Harada syndrome was sought by means of the migration-inhibition factor technique with human myelin basic protein. The test was carried out in four patients who had recent manifestations of the syndrome, two of whom were evaluated both before and after... | 83,972 | [
0.04342597,
-0.06605297,
-0.05166919,
-0.3725766,
0.01546333,
-0.3490315,
0.06845792,
0.1554513,
0.0258618,
-0.1597645,
0.0491818,
-0.04626308,
0.01224356,
-0.1952664,
-0.2246736,
0.02974549,
-0.3102873,
0.07388882,
-0.1640076,
0.1832522,
0.1774157,
0.1079683,
0.2064179,
... |
Histochemical staining of lymphatic anchoring filaments. | Lymphatic anchoring filaments are stained by means of histochemical methods that demonstrate disulfide-groups. Thiosulfation of sections either followed by aldehyde-fuchsin staining or by Alcian Blue +0.8 M MgCl2 staining has been used. Lymphatic anchoring filaments display striking fine structural similarities to "ela... | 83,976 | [
0.0004195416,
0.01226812,
-0.3876272,
0.04150287,
0.05891539,
-0.241597,
0.0960483,
0.07856005,
-0.05820172,
0.3122466,
0.05927069,
-0.0785253,
0.4892955,
0.01211582,
-0.4300195,
-0.0001036169,
-0.3652784,
-0.1014737,
-0.1850865,
0.4255603,
0.2758875,
-0.1187885,
0.019024... |
Electron microscopic observations of polysaccharide components in polymyxin B treated outer membranes from Serratia marcescens. | Treatment of outer membranes of Serratia marcescens with polymyxin B results in the formation of blebs. This effect is thought to be due to the action of the antibiotic on the lipopolysaccharides, proteins, phospholipids or a combination thereof. It is unclear whether this effect is dissociative, degradative or due to ... | 83,989 | [
0.09143598,
-0.001238109,
-0.06030995,
0.07376455,
-0.09831922,
-0.1513077,
0.06004067,
-0.03441092,
0.1872278,
0.0856804,
0.01873385,
-0.07571852,
-0.2996076,
-0.1323932,
-0.1101481,
0.07872885,
-0.5056377,
-0.2402532,
0.2221843,
-0.03039183,
0.5810058,
0.1841015,
0.1131... |
A requirement for ATP for beta-galactoside transport by Bacillus alcalophilus. | Lactose-grown cells of Bacillus alcalophilus actively transported methylthio-beta, D-galactoside (TMG) in a range of pH values from 7.5 to 10.5 with a pH optimum at 8.5. The TMG was accumulated in a chemically unmodified form, and cell extracts failed to catalyze either ATP or P-enolpyruvate-dependent phosphorylation o... | 83,995 | [
-0.2122331,
-0.2232312,
-0.3559556,
0.2215733,
0.01395908,
-0.0748478,
-0.2650311,
0.2548067,
-0.09902813,
-0.152566,
0.06215965,
0.2762595,
-0.1261698,
0.05891802,
-0.298183,
0.1954922,
-0.3002573,
0.2534178,
-0.1259224,
0.1277712,
0.6595421,
0.009714084,
-0.06083339,
... |
A rapid ocular smear technique for optometrists: a preliminary report. | The preliminary report discusses a clinical procedure in acquiring conjunctival smears, fixing the acquired sample and interpreting the results. Included is a description of the white blood cells frequently found in ocular smears and the clinical significance of each. | 84,009 | [
-0.1621426,
0.01270599,
-0.3177312,
-0.08997495,
-0.0118952,
-0.168935,
-0.3827404,
0.06036813,
0.3209106,
-0.06399948,
0.08948937,
0.4948847,
0.01082364,
0.1448983,
-0.1151618,
-0.1621474,
-0.4340465,
-0.1223996,
0.0236849,
0.06481335,
0.04433774,
0.1267824,
-0.08161938,... |
Identification of a subspecies-specific capsular antigen from Bacteroides melaninogenicus subspecies asaccharolyticus by immunofluorescence and electron microscopy. | An indirect fluorescent antibody test was developed with the use of hyperimmune rabbit antiserum to a purified capsular polysaccharide of Bacteroides melaninogenicus subspecies asaccharolyticus. All of 23 strains of B. melaninogenicus subspecies asaccharolyticus were fluorescence-positive in this test. All 11 strains o... | 84,036 | [
0.2687574,
0.1410449,
-0.1852378,
0.1534491,
0.04546234,
-0.2594914,
0.1598447,
0.3431314,
0.0437992,
0.2321512,
0.1051937,
-0.06415978,
-0.2354874,
-0.3894332,
-0.297204,
-0.4352525,
-0.3438684,
0.3375029,
0.06251051,
-0.3180928,
0.3811815,
-0.3229566,
0.1765702,
-0.17... |
Early detection of aminoglycoside nephrotoxicity with urinary beta-2-microglobulin. | We used a radioimmunoassay to evaluate the changes in the urinary excretion of beta2-microglobulin (beta2M) in 21 patients receiving aminoglycosides for treatment of infection. Excretion of this protein rose to a peak at least 5 times the baseline value in the urine, and declined rapidly to control values after drug ad... | 84,037 | [
-0.2943658,
-0.03540572,
-0.3881073,
-0.2228224,
0.0688078,
-0.1844509,
-0.4012743,
0.08236919,
0.1652218,
-0.07760377,
0.0838219,
0.1971297,
0.2732776,
0.2654711,
-0.2985959,
-0.03574139,
-0.1011922,
0.1321787,
-0.1945447,
0.0971028,
0.2474284,
-0.008773542,
0.04563893,
... |
Lymphocyte specificity to protein antigens. II. Fine specificity of T-cell activation with cytochrome c and derived peptides as antigenic probes. | Murine T-lymphocyte specificity was determined in a system of antigen driven in vitro T-cell proliferation using cytochrome c molecules from different species, their derived peptides and reconstituted hybrid proteins. It was observed that primed T cells could discriminate between peptide fragments which differed from e... | 84,044 | [
0.04085359,
-0.125425,
-0.2505685,
0.19442,
0.2246882,
-0.2714279,
0.2062801,
0.3038494,
0.2153066,
0.2849582,
0.00669342,
-0.05026593,
0.2004573,
0.2374528,
-0.2327916,
-0.4705952,
-0.7120069,
-0.1636719,
0.07954049,
0.1182762,
0.3758069,
0.05209583,
-0.2331238,
0.0385... |
Klinefelter syndrome and neurological disease. | Six patients with Klinefelter syndrome (47,XXY) and different neurological disease are described. Essential tremor has been reported repeatedly but its significance deserves further studies. The prevalence of epilepsy with the Klinefelter syndrome is higher in comparison with the normal poplation, but it is not greater... | 84,058 | [
-0.1285902,
0.3627508,
0.3004072,
0.02835466,
-0.3653179,
-0.1759471,
-0.150772,
-0.2772333,
-0.1442624,
0.2136426,
0.4158266,
0.3446632,
-0.0804949,
0.2062383,
-0.2920237,
-0.03866963,
-0.1518245,
0.1360813,
-0.2997608,
-0.1490689,
-0.1484931,
0.2916921,
-0.06207354,
0... |
Serologically defined, unique surface antigen on a mouse mammary adenocarcinoma. | Syngeneic A.SW mice were immunized with sublethal viable cells of a spontaneous mammary adenocarcinoma S3W. The serum was tested by complement-dependent cytotoxicity against in vitro-cultured S3W cells and a spectrum of controls. S3W cells were found to react with at least four different kinds of antibodies in the seru... | 84,092 | [
-0.1100767,
-0.2305049,
-0.1397567,
-0.4043257,
-0.02270542,
-0.01946335,
-0.1013903,
0.04081857,
0.3161117,
0.2696838,
0.01660421,
0.063685,
0.3088296,
-0.1552245,
-0.1766042,
-0.1091367,
-0.5118893,
-0.2399501,
-0.1662976,
0.2725524,
0.3063523,
0.06272525,
-0.3443784,
... |
Social inequalities undiminished. | Traditional differences in death-rates by social class continue in Britain in the 1970s, mostly at lower levels of mortality. The professions do well, unskilled workers and their families particularly badly. Data on health services are scanty, but they suggest that lower-class families, with greater needs, do not make ... | 84,138 | [
-0.3464395,
0.4238865,
-0.139944,
0.06995256,
0.03288379,
-0.1112158,
-0.05748502,
0.0004940925,
-0.2660338,
0.1649228,
0.0530673,
0.001339001,
-0.3113661,
-0.3584245,
-0.1120847,
-0.06396624,
-0.06809167,
0.2208701,
-0.09349378,
0.1882102,
0.1472383,
0.5183196,
-0.150195... |
Growth-stimulating factor in regenerating canine liver. | Extracts from dog livers which had been regenerating for 24, 48, and 72 h after hepatectomy were infused for 6 h into the left portal vein of animals which had fresh portacaval shunts (Eck fistula) and which were killed 2 and 3 days later. The brief exposure to the 48-h and especially the 72-h regenerating liver extrac... | 84,151 | [
-0.1374391,
-0.1052742,
-0.2438169,
-0.1413849,
0.3611257,
-0.07272477,
0.17673,
-0.2612878,
0.1641031,
0.002795617,
0.03382258,
0.05817641,
-0.1824762,
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-0.2602946,
0.0470992,
0.243525,
0.05782105,
0.2042097,
-0.09692697,
0.3040599,
-0.07282853,
... |
Seminiferous tubule hypercurvature: A newly recognised common syndrome of human male infertility. | Testicular biopsy specimens from 42 of a series of 70 consecutive cases of primary male infertility and from 25 normal controls were morphometrically analysed. Although all the specimens from infertile males were normal by conventional histological standards, stereological measures of curvature in histological sections... | 84,205 | [
0.04873563,
0.04099778,
-0.1608115,
-0.08985077,
0.05267511,
-0.1865752,
-0.03527544,
0.07211476,
-0.0003495782,
0.08966034,
0.1947563,
0.2499492,
-0.1200133,
0.2311102,
-0.1706801,
-0.3617056,
-0.08523192,
-0.00495777,
-0.1865398,
-0.2040134,
0.05808422,
0.2145007,
-0.05... |
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