title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Carbapenem-resistant Klebsiella pneumoniae infections in kidney transplant recipients: a case-control study. | Carbapenem-resistant Klebsiella pneumoniae (CRKP) infections have emerged as a significant challenge in solid organ transplantation. CRKP infections in other patient populations have been associated with higher mortality, when compared to infections caused by carbapenem-sensitive K. pneumoniae (CSKP). The aim of this s... | 25,092,500 | [
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Promoting Female Condom Use Among Female University Students in KwaZulu-Natal, South Africa: Results of a Randomized Behavioral Trial. | Relatively few interventions have tested the efficacy of female condom promotion either alone or in combination with other barrier methods. We evaluated the efficacy of a two-session (enhanced) cognitive-behavioral intervention (EI) (n = 147) against a one-session control (minimal) educational intervention (MI) (n = 14... | 25,092,513 | [
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Individual-Level and Partner-Level Predictors of Newly Diagnosed HIV Infection Among Black and White Men Who Have Sex with Men in Baltimore, MD. | Black MSM continue to be the group most disproportionately impacted by HIV in the United States. This study assesses the relationship between partner-level and respondent-level characteristics and newly diagnosed HIV infection among a sample of MSM. Ego-centric data were gathered using venue-based time-space sampling o... | 25,092,514 | [
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Inhibition of key markers linked with spermatogenesis and cellular ATP by subchronic exposure to leachate in a rat model. | Few or no studies have measured the toxic effects of subchronic exposure to leachate using key markers linked with spermatogenesis and cellular adenosine triphosphate (ATP) in an experimental rat model. This study was undertaken to evaluate the toxic effects of leachate obtained from the Elewi Odo municipal battery-rec... | 25,092,531 | [
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Comparison between results of high tibial osteotomy above and below tibial tubercle in relation to future total knee arthroplasty. | This prospective study included 50 patients with medial compartment osteoarthritis and varus knees. Twenty-five patients had high tibial closed wedge osteotomy above the tibial tubercle (TT) (group I), and the other 25 had the osteotomy just below it (group II). The two groups were matched. The osteotomies in both grou... | 25,092,563 | [
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Anti-C1q autoantibodies from active lupus nephritis patients could inhibit the clearance of apoptotic cells and complement classical pathway activation mediated by C1q in vitro. | Anti-C1q antibodies are prevalent in patients with active lupus nephritis and were found to be closely associated with renal involvement and predictive for a flare of nephritis. However, the pathogenesis of anti-C1q antibodies involved in human lupus nephritis remains unclear. C1q, which plays a key role in apoptotic c... | 25,092,568 | [
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Accuracy and reliability of pulp/tooth area ratio in upper canines by peri-apical X-rays. | Due to the real need for careful staff training in age assessment, in order to improve capacity, consistency and competence, new research on the reliability and repeatability of methods frequently used in age assessment are required. The aim of this study was twofold: first, to test the accuracy of this method for age ... | 25,092,574 | [
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Molecular weight distribution characterization of hydrophobe-modified hydroxyethyl cellulose by size-exclusion chromatography. | Size-exclusion chromatography (SEC) of hydrophobe-modified hydroxyethyl cellulose (HmHEC) is challenging because polymer chains are not isolated in solution due to association of hydrophobic groups and hydrophobic interaction with column packing materials. An approach to neutralize these hydrophobic interactions was de... | 25,092,594 | [
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Obesity in autoimmune diseases: not a passive bystander. | In the last decades, autoimmune diseases have experienced a dramatic increase in Western countries. The involvement of environmental factors is strongly suspected to explain this rise. Particularly, over the same period, obesity has followed the same outbreak. Since the exciting discovery of the secretory properties of... | 25,092,612 | [
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The pig as an animal model for human pathologies: A proteomics perspective. | Traditional biomedical models are easy to manage in experimental facilities and allow fast and affordable basic genetic studies related to human disorders, but in some cases they do not always represent the complexity of their physiology. Translational medicine demands selected models depending on the particularities o... | 25,092,613 | [
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The prevalence of undiagnosed diabetes mellitus and the association of baseline glycemic control on mortality in the intensive care unit: a prospective observational study. | Hyperglycemia is common during critical illness and can adversely affect clinical outcomes. We sought to determine the prevalence of undiagnosed diabetes among medical intensive care unit (MICU) patients with stress hyperglycemia and the association between baseline glycemic control and mortality. A prospective, observ... | 25,092,614 | [
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Establishment of multiple pesticide biodegradation capacities from pesticide-primed materials in on-farm biopurification system microcosms treating complex pesticide-contaminated wastewater. | On-farm biopurification systems (BPSs) treat pesticide-containing wastewater at farms by biodegradation and sorption processes. The inclusion of pesticide-primed material carrying a pesticide-degrading microbial community is beneficial for improving biodegradation, but no data exist for treating wastewater containing m... | 25,092,626 | [
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Experiences with provider and parental attitudes and practices regarding the administration of multiple injections during infant vaccination visits: lessons for vaccine introduction. | An increasing proportion of childhood immunization visits include administration of multiple injections. Future introduction of vaccines to protect against multiple diseases will further increase the number of injections at routine immunization childhood visits, particularly in developing countries that are still scali... | 25,092,632 | [
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Trials in the prevention of type 1 diabetes: current and future. | A major thrust in type 1 diabetes research is stopping the destruction of beta cells that leads to type 1 diabetes. Research over the past 30 years has defined genetic factors and evidence of autoimmunity that have led to the development of robust prediction models in those at high risk for type 1 diabetes. The ability... | 25,092,646 | [
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Modulation of a cytoskeletal calpain-like protein induces major transitions in trypanosome morphology. | Individual eukaryotic microbes, such as the kinetoplastid parasite Trypanosoma brucei, have a defined size, shape, and form yet transition through life cycle stages, each having a distinct morphology. In questioning the structural processes involved in these transitions, we have identified a large calpain-like protein ... | 25,092,656 | [
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Two sources of meaning in infant communication: preceding action contexts and act-accompanying characteristics. | How do infants communicate before they have acquired a language? This paper supports the hypothesis that infants possess social-cognitive skills that run deeper than language alone, enabling them to understand others and make themselves understood. I suggested that infants, like adults, use two sources of extralinguist... | 25,092,662 | [
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How arbitrary is language? | It is a long established convention that the relationship between sounds and meanings of words is essentially arbitrary--typically the sound of a word gives no hint of its meaning. However, there are numerous reported instances of systematic sound-meaning mappings in language, and this systematicity has been claimed to... | 25,092,667 | [
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Origin of symbol-using systems: speech, but not sign, without the semantic urge. | Natural language--spoken and signed--is a multichannel phenomenon, involving facial and body expression, and voice and visual intonation that is often used in the service of a social urge to communicate meaning. Given that iconicity seems easier and less abstract than making arbitrary connections between sound and mean... | 25,092,671 | [
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Linezolid manifests a rapid and dramatic therapeutic effect for patients with life-threatening tuberculous meningitis. | We conducted a retrospective cohort study of patients with MRC grade II/III tuberculous meningitis (TBM) who accepted a background antitubercular regimen (BR) with or without linezolid (LZD). At the 4th week, the LZD-BR group achieved a faster and higher percentage of Glasgow coma scale recovery and temperature recover... | 25,092,692 | [
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The activity of glycopeptide antibiotics against resistant bacteria correlates with their ability to induce the resistance system. | Glycopeptide antibiotics containing a hydrophobic substituent display the best activity against vancomycin-resistant enterococci, and they have been assumed to be poor inducers of the resistance system. Using a panel of 26 glycopeptide derivatives and the model resistance system in Streptomyces coelicolor, we confirmed... | 25,092,694 | [
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High prevalence of extended-spectrum β-lactamase, plasmid-mediated AmpC, and carbapenemase genes in pet food. | We evaluated the pet food contained in 30 packages as a potential origin of extended-spectrum cephalosporin-resistant Gram-negative organisms and β-lactamase genes (bla). Live bacteria were not detected by selective culture. However, PCR investigations on food DNA extracts indicated that samples harbored the blaCTX-M-1... | 25,092,703 | [
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Physiologically based pharmacokinetic prediction of telmisartan in human. | A previously developed physiologically based pharmacokinetic model for hepatic transporter substrates was extended to an organic anion transporting polypeptide substrate, telmisartan. Predictions used in vitro data from sandwich culture human hepatocyte and human liver microsome assays. We have developed a novel method... | 25,092,714 | [
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Quality-of-life measures for use within care homes: a systematic review of their measurement properties. | the aims of this review were (i) to identify quality-of-life (QoL) measures which have had their measurement properties validated in people residing in care homes or nursing homes, and to critically compare and summarise these instruments and (ii) to make recommendations for measurement instruments. bibliographic datab... | 25,092,719 | [
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Statin use after colorectal cancer diagnosis and survival: a population-based cohort study. | To investigate whether statins used after colorectal cancer diagnosis reduce the risk of colorectal cancer-specific mortality in a cohort of patients with colorectal cancer. A cohort of 7,657 patients with newly diagnosed stage I to III colorectal cancer were identified from 1998 to 2009 from the National Cancer Data R... | 25,092,779 | [
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Gemtuzumab ozogamicin in children and adolescents with de novo acute myeloid leukemia improves event-free survival by reducing relapse risk: results from the randomized phase III Children’s Oncology Group trial AAML0531. | To improve survival rates in children with acute myeloid leukemia (AML), we evaluated gemtuzumab-ozogamicin (GO), a humanized immunoconjugate targeted against CD33, as an alternative to further chemotherapy dose escalation. Our primary objective was to determine whether adding GO to standard chemotherapy improved event... | 25,092,781 | [
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Early activation of the kynurenine pathway predicts early death and long-term outcome in patients resuscitated from out-of-hospital cardiac arrest. | The kynurenine pathway (KP) is the major route of tryptophan (TRP) catabolism and is activated by inflammation and after cardiac arrest in animals. We hypothesized that the KP activation level correlates with severity of post-cardiac arrest shock, early death, and long-term outcome. Plasma was obtained from 245 patient... | 25,092,787 | [
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The use of crowdsourcing for dietary self-monitoring: crowdsourced ratings of food pictures are comparable to ratings by trained observers. | Crowdsourcing dietary ratings for food photographs, which uses the input of several users to provide feedback, has potential to assist with dietary self-monitoring. This study assessed how closely crowdsourced ratings of foods and beverages contained in 450 pictures from the Eatery mobile app as rated by peer users (fe... | 25,092,793 | [
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Patterns of innervation of the lacrimal gland with clinical application. | Parasympathetic stimulation of the lacrimal gland is responsible for tear production, and this innervation originates from fibers conveyed in the facial nerve. After synapse in the pterygopalatine ganglion, postsynaptic parasympathetic fibers travel within the zygomatic and zygomaticotemporal nerves (ZTN) into the orbi... | 25,092,807 | [
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Medicaid admissions and readmissions: understanding the prevalence, payment, and most common diagnoses. | Reducing hospital readmissions is a way to improve care and reduce avoidable costs. However, there have been few studies of readmissions in the Medicaid population. We sought to characterize acute care hospital admissions and thirty-day readmissions in the Medicaid population through a retrospective analysis in ninetee... | 25,092,834 | [
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Children's health insurance program premiums adversely affect enrollment, especially among lower-income children. | Both Medicaid and the Children's Health Insurance Program (CHIP), which are run by the states and funded by federal and state dollars, offer health insurance coverage for low-income children. Thirty-three states charged premiums for children at some income ranges in CHIP or Medicaid in 2013. Using data from the 1999-20... | 25,092,836 | [
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Exploring regional differences in the reading competencies of Italian students. | Recently, the study of territorial differences in educational outcomes has assumed a particular importance for the policy strategies related to the socioeconomic conditions of different geographical areas. In Italy, international surveys for student assessments have introduced a regional stratification only recently, a... | 25,092,864 | [
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RHEX, a novel regulator of human erythroid progenitor cell expansion and erythroblast development. | Ligation of erythropoietin (EPO) receptor (EPOR) JAK2 kinase complexes propagates signals within erythroid progenitor cells (EPCs) that are essential for red blood cell production. To reveal hypothesized novel EPOR/JAK2 targets, a phosphotyrosine (PY) phosphoproteomics approach was applied. Beyond known signal transduc... | 25,092,874 | [
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Dietary manipulation of oncogenic microRNA expression in human rectal mucosa: a randomized trial. | High red meat (HRM) intake is associated with increased colorectal cancer risk, while resistant starch is probably protective. Resistant starch fermentation produces butyrate, which can alter microRNA (miRNA) levels in colorectal cancer cells in vitro; effects of red meat and resistant starch on miRNA expression in viv... | 25,092,886 | [
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Potential immune mechanisms associated with anemia in Plasmodium vivax malaria: a puzzling question. | The pathogenesis of malaria is complex, generating a broad spectrum of clinical manifestations. One of the major complications and concerns in malaria is anemia, which is responsible for considerable morbidity in the developing world, especially in children and pregnant women. Despite its enormous health importance, th... | 25,092,911 | [
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Automated conversation system before pediatric primary care visits: a randomized trial. | Interactive voice response systems integrated with electronic health records have the potential to improve primary care by engaging parents outside clinical settings via spoken language. The objective of this study was to determine whether use of an interactive voice response system, the Personal Health Partner (PHP), ... | 25,092,938 | [
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Axial length measurement acquisition rates of two optical biometers in cataractous eyes. | To compare the ability of two optical biometers to acquire the axial length (AL) measurement in cataractous eyes. This prospective, comparative, single-center study comprised 105 eyes (63 patients). AL was acquired by the composite mean value of 20 measurements (composite-20 IM) and five measurements (composite-5 IM) (... | 25,092,960 | [
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Cerebellar dysregulation and heterogeneity of mood disorders. | This paper discusses diverse studies to consider the hypothesis that cerebellar pathology supports the heterogeneous metabolic pathologies of mood disorders. The evidence presented includes studies selected from the following areas of scientific research: magnetic resonance imaging, histology, clinical syndromes, compa... | 25,092,983 | [
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High expression of HEF1 is associated with poor prognosis in urinary bladder carcinoma. | Human enhancer of filamentation 1 (HEF1) is a multidomain scaffolding protein that has been thought to play an important role in the tumor progression of various cancers. HEF1 expression has not previously been reported in urinary bladder carcinoma, and little is known about its prognostic significance. The aim of this... | 25,092,988 | [
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Pioglitazone improves the cardio-ankle vascular index in patients with type 2 diabetes mellitus treated with metformin. | Type 2 diabetes is known to be associated with elevated cardiovascular mortality. Pioglitazone improves blood pressure (BP) and pulse wave velocity (PWV), which is an arterial stiffness parameter. Arterial stiffness is closely associated with cardiovascular disease. However, PWV is correlated with BP. The cardio-ankle ... | 25,092,992 | [
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Cognitive control in bilinguals: Advantages in Stimulus-Stimulus inhibition. | Bilinguals have been shown to outperform monolinguals at suppressing task-irrelevant information and on overall speed during cognitive control tasks. Here, monolinguals' and bilinguals' performance was compared on two nonlinguistic tasks: a Stroop task (with perceptual Stimulus-Stimulus conflict among stimulus features... | 25,093,009 | [
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The effects of a multi-ingredient dietary supplement on body composition, adipokines, blood lipids, and metabolic health in overweight and obese men and women: a randomized controlled trial. | The present study investigated the effects of a multi-ingredient dietary supplement (MIDS) containing caffeine, conjugated linoleic acid (CLA), green tea, and branched-chain amino acids (BCAA) taken for 8 weeks on body composition, blood lipid profile, glucose, insulin, adiponectin, leptin, and high-sensitivity C-react... | 25,093,015 | [
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Electrophoretic Deposition of Carbon Nanotubes over TiO2 Nanotubes: Evaluation of Surface Properties and Biocompatibility. | Titanium (Ti) is often used as an orthopedic and dental implant material due to its better mechanical properties, corrosion resistance, and excellent biocompatibility. Formation of TiO2 nanotubes (TiO2 NTs) on titanium is an interesting surface modification to achieve controlled drug delivery and to promote cell growth... | 25,093,017 | [
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Large deletion causing von Hippel-Lindau disease and hereditary breast cancer syndrome. | Patients with intragenic mutations of the VHL gene have a typical disease presentation. However in cases of large VHL gene deletions which involve other genes in the proximity of the VHL gene a presentation of the disease can be different. To investigate whether large VHL deletions that remove the FANCD2 gene have an e... | 25,093,046 | [
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The SNPs (-1654C/T, -1641A/G and -1476A/T) of protein C promoter are associated with susceptibility to pulmonary thromboembolism in a Chinese population. | Pulmonary thromboembolism (PTE) is a common and potentially lethal disease. It is significant to investigate the gene mutations of protein C for clarifying the etiology of PTE. In this present study, we investigated the promoter region polymorphism sites including -1654C/T, -1641A/G and -1476A/T of the protein C gene i... | 25,093,091 | [
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Predictive value of lactate in unselected critically ill patients: an analysis using fractional polynomials. | Hyperlactatemia has long been associated with poor clinical outcome in varieties of intensive care unit (ICU) patients. However, the impact of temporal changes in lactate has not been well established and there are some shortcomings in model building in previous studies. The present study aims to investigate the associ... | 25,093,098 | [
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Structural Features of the Telomerase RNA Gene in the Naked Mole Rat Heterocephalus glaber. | Telomere length, an important feature of life span control, is dependent on the activity of telomerase (a key enzyme of the telomere-length-maintaining system). Telomerase RNA is a component of telomerase and, thus, is crucial for its activity. The structures of telomerase RNA genes and their promoter regions were comp... | 25,093,110 | [
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High-throughput Method of One-Step DNA Isolation for PCR Diagnostics of Mycobacterium tuberculosis. | The efficiency of one-step and multi-step protocols of DNA isolation from lysed sputum samples containing the Mycobacterium tuberculosis complex has been compared. DNA was isolated using spin-cartridges containing a special silica-based sorbent modified with fluoroplast and polyaniline, or using an automated isolation ... | 25,093,111 | [
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Lipid-protein nanodiscs offer new perspectives for structural and functional studies of water-soluble membrane-active peptides. | Lipid-protein nanodiscs (LPNs) are nanoscaled fragments of a lipid bilayer stabilized in solution by the apolipoprotein or a special membrane scaffold protein (MSP). In this work, the applicability of LPN-based membrane mimetics in the investigation of water-soluble membrane-active peptides was studied. It was shown th... | 25,093,115 | [
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Construction of a pIX-modified Adenovirus Vector Able to Effectively Bind to Nanoantibodies for Targeting. | Current targeting strategies for genetic vectors imply the creation of a specific vector for every targeted receptor, which is time-consuming and expensive. Therefore, the development of a universal vector system whose surface can specifically bind molecules to provide efficient targeting is of particular interest. In ... | 25,093,116 | [
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Idelalisib for the treatment of chronic lymphocytic leukemia. | Chronic lymphocytic leukemia is the most common leukemia in the United States. It is a slowly progressive disease, with an 82% five-year survival rate. The treatment strategies are highly individualized with patients in the early and stable stages typically not requiring treatment. However, those with progressive or cl... | 25,093,123 | [
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Severe Hypercholesterolemia: A Unique Presentation of Non-Hodgkin's Lymphoma in a Patient with Neurofibromatosis Type 1. | We report a case of non-Hodgkin's lymphoma (NHL) with an unusual initial manifestation as severe hypercholesterolemia and obstructive jaundice in a patient with neurofibromatosis type 1 (NF 1). NHL should be considered in the evaluation of obstructive jaundice alone or in combination with severe hypercholesterolemia. R... | 25,093,126 | [
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Unusual relapse of primary central nervous system lymphoma at site of lumbar puncture. | Primary CNS lymphoma (PCNSL) is a rare non-Hodgkin's lymphoma confined to the CNS. Local relapse of this disease is common, but extracranial or subcutaneous metastasis is rare with only a few cases being reported in literature. We report a 63-year-old male patient, who responded well to treatment for PCNSL but relapsed... | 25,093,130 | [
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Extended inferior turbinate flap for endoscopic reconstruction of skull base defects. | Objective When the use of the nasoseptal flap for endoscopic skull base reconstruction has been precluded, the posterior pedicle inferior turbinate flap is a viable option for small midclival defects. Limitations of the inferior turbinate flap include its small surface area and limited arc of rotation. We describe a no... | 25,093,144 | [
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Curcumin loaded microsponges for colon targeting in inflammatory bowel disease: fabrication, optimization, and in vitro and pharmacodynamic evaluation. | The present study was aimed to develop and optimize the microsponges of curcumin for colon specific drug delivery in a view to bypass the upper gastrointestinal tract (GIT) for enhanced therapeutic effect. Microsponges were developed by quasi emulsion solvent diffusion method using 3(2) full factorial design. Prepared ... | 25,093,165 | [
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Predictive factors affecting the short term and long term exodrift in patients with intermittent exotropia after bilateral rectus muscle recession and its effect on surgical outcome. | To determine the predictive factors that affect short term and long term postoperative drift in intermittent exotropia after bilateral lateral rectus recession and to evaluate its effect on surgical outcome. Retrospective review of 203 patients with diagnosis of intermittent exotropia, who had surgical corrections with... | 25,093,170 | [
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... |
Neuroendocrine differentiation is a prognostic factor for stage II poorly differentiated colorectal cancer. | Neuroendocrine differentiation (NED) in colorectal cancer is an indistinct phenomenon and may define a new cancer subtype, especially in the poorly differentiated colorectal cancer (PDCRC). The clinical features of PDCRC with NED remain controversial, thus confusing the implementation of individualized treatment. This ... | 25,093,184 | [
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Mutational analysis of oculocutaneous albinism: a compact review. | Oculocutaneous albinism (OCA) is an autosomal recessive disorder caused by either complete lack of or a reduction of melanin biosynthesis in the melanocytes. The OCA1A is the most severe type with a complete lack of melanin production throughout life, while the milder forms OCA1B, OCA2, OCA3, and OCA4 show some pigment... | 25,093,188 | [
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Role of rutin on nitric oxide synthesis in human umbilical vein endothelial cells. | Nitric oxide (NO), produced by endothelial nitric oxide synthase (eNOS), is a major antiatherogenic factor in the blood vessel. Oxidative stress plays an important role in the pathogenesis of various cardiovascular diseases, including atherosclerosis. Decreased availability of endothelial NO promotes the progression of... | 25,093,198 | [
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Distribution of subsequent primary invasive melanomas following a first primary invasive or in situ melanoma Queensland, Australia, 1982-2010. | Melanoma survivors are known to have a highly elevated risk of subsequent primary melanomas. To determine the relative risk of subsequent primary invasive melanomas following a first primary invasive or in situ melanoma, with a focus on body site. A retrospective cohort study was conducted using population-based admini... | 25,093,216 | [
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Depressive symptoms precede memory decline, but not vice versa, in non-demented older adults. | To determine whether depressive symptoms typically precede or follow memory declines. An autoregressive latent trajectory model was used to examine the direction of the relationship between depressive symptoms and memory decline observed over 12 years. Washington/Hamilton Heights Inwood Columbia Aging Project, a commun... | 25,093,232 | [
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Guiding brain tumor resection using surface-enhanced Raman scattering nanoparticles and a hand-held Raman scanner. | The current difficulty in visualizing the true extent of malignant brain tumors during surgical resection represents one of the major reasons for the poor prognosis of brain tumor patients. Here, we evaluated the ability of a hand-held Raman scanner, guided by surface-enhanced Raman scattering (SERS) nanoparticles, to ... | 25,093,240 | [
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A few positively charged residues slow movement of a polypeptide chain across the endoplasmic reticulum membrane. | Many polypeptide chains are translocated across and integrated into the endoplasmic reticulum membrane through protein-conducting channels. During the process, amino acid sequences of translocating polypeptide chains are scanned by the channels and classified to be retained in the membrane or translocated into the lume... | 25,093,244 | [
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Responsive Design, Weighting, andVariance Estimation in the 2006-2010 National Survey of Family Growth. | Objective-The National Survey of Family Growth (NSFG) collects data on pregnancy, childbearing, men's and women's health, and parenting from a national sample of men and women aged 15-44 in the United States. The 2006-2010 NSFG design was a significant departure from the previous periodic design, used in 1973-2002. Thi... | 25,093,250 | [
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The sensitivity of the Kleihauer-Betke test for placental abruption. | The Kleihauer-Betke (KB) test evaluates fetal blood in the maternal circulation, and is often used when placental abruption is suspected. At our centre, it is the protocol to perform a KB test in all suspected cases of abruption. We carried out a retrospective study of all cases of abruption that occurred at our centre... | 25,093,255 | [
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Molecular cloning and expression analysis of tea plant aquaporin (AQP) gene family. | The role of aquaporin proteins (AQPs) has been extensively studied in plants. However, the information of AQPs in the tea plant (Camellia sinensis) is unclear. In this manuscript, we isolated 20 full-length AQP cDNAs from the tea plant, and these sequences were classified into five subfamilies. The genes in these subfa... | 25,093,260 | [
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Directed evolution of squalene synthase for dehydrosqualene biosynthesis. | Squalene synthase (SQS) catalyzes the first step of sterol/hopanoid biosynthesis in various organisms. It has been long recognized that SQSs share a common ancestor with carotenoid synthases, but it is not known how these enzymes selectively produce their own product. In this study, SQSs from yeast, human, and bacteria... | 25,093,296 | [
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[Pathogenesis of HIV-1]. | The human immunodeficiency virus type 1 (HIV-1) establishes a chronic, lifelong infection finally leading to the acquired immunodeficiency syndrome (AIDS), which is characterized by the onset of opportunistic infections and tumors. The natural course of HIV-1 infections is very variable and depends on the virus and its... | 25,093,308 | [
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Isolation and characterization of CD34+ blast-derived exosomes in acute myeloid leukemia. | Exosomes are membrane-bound vesicles found in all biological fluids. AML patients' plasma collected at diagnosis contains elevated exosome levels relative to normal donor (ND) plasma. The molecular profile of AML exosomes changes in the course of therapy and may serve as a measure of disease progression or response to ... | 25,093,329 | [
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A new 2α,5α,10β,14β-tetraacetoxy-4(20),11-taxadiene (SIA) derivative overcomes paclitaxel resistance by inhibiting MAPK signaling and increasing paclitaxel accumulation in breast cancer cells. | Tumor resistance due to multiple mechanisms seriously hinders the efficacy of chemotherapy drugs such as paclitaxel. The most widely studied P-glycoprotein inhibitors still have limited ability to reverse resistance in the clinic. In this study, NPB304, a novel Sinenxan A (SIA) derivative, was found to significantly se... | 25,093,335 | [
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Electronic structure, novel synthesis, and O-H...O and C-H...O interactions in two 6-oxopiperidine-2-carboxylic acid derivatives. | Molecules of (S)-6-oxo-1-(thiophen-2-ylmethyl)piperidine-2-carboxylic acid, C11H13NO3S, crystallize as single enantiomers in the space group P21 and the thiophene ring is disordered over two positions, while (S)-6-oxo-1-(thiophen-3-ylmethyl)piperidine-2-carboxylic acid, C11H13NO3S, crystallizes as a single enantiomer i... | 25,093,366 | [
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Topological analysis of the three-dimensional coordination polymer poly[(μ4-azido)[μ4-5-(pyridin-4-yl)tetrazolido]disilver(I)]. | The title compound, [Ag2(C6H4N4)(N3)]n, was obtained under hydrothermal conditions at 433 K. The asymmetric unit of the orthorhombic space group (Pna21) consists of two Ag(+) cations, an anionic 5-(pyridin-4-yl)tetrazolide (4-ptz(-)) ligand and an anionic azide ligand. Both Ag(+) centres are coordinated by four N atoms... | 25,093,367 | [
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Homoleptic 2,2'-bipyridine metalates(-I) of iron and cobalt, one cocrystallized with an anthracene radical anion and the other with neutral anthracene. | Homoleptic 2,2'-bipyridine (bipy) metalates of iron and cobalt have been synthesized directly from the corresponding homoleptic anthracene metalates. In the iron structure, bis[([2.2.2]cryptand)potassium(I)] tris(2,2'-bipyridine)ferrate(-I) anthracene(-I), [K(C18H36N2O6)]2[Fe(C10H8N2)3](C14H10), the asymmetric unit con... | 25,093,368 | [
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... |
Web search behavior and information needs of people with multiple sclerosis: focus group study and analysis of online postings. | Multiple sclerosis (MS) patients and their family members increasingly seek health information on the Internet. There has been little exploration of how MS patients integrate health information with their needs, preferences, and values for decision making. The INtegrating and Deriving Evidence, Experiences, and Prefere... | 25,093,374 | [
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Obesity-related genomic loci are associated with type 2 diabetes in a Han Chinese population. | Obesity is a well-known risk factor for type 2 diabetes. Genome-wide association studies have identified a number of genetic loci associated with obesity. The aim of this study is to examine the contribution of obesity-related genomic loci to type 2 diabetes in a Chinese population. We successfully genotyped 18 obesity... | 25,093,408 | [
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Length and GC content variability of introns among teleostean genomes in the light of the metabolic rate hypothesis. | A comparative analysis of five teleostean genomes, namely zebrafish, medaka, three-spine stickleback, fugu and pufferfish was performed with the aim to highlight the nature of the forces driving both length and base composition of introns (i.e., bpi and GCi). An inter-genome approach using orthologous intronic sequence... | 25,093,416 | [
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Pneumococcal vaccines for cystic fibrosis. | Invasive pneumococcal disease is associated with significant mortality and many countries have introduced routine pneumococcal vaccination into their childhood immunisation programmes. Whilst pneumococcal disease in cystic fibrosis is uncommon, pneumococcal immunisation may offer some protection against pulmonary exace... | 25,093,421 | [
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A novel method for non-transferrin-bound iron quantification by chelatable fluorescent beads based on flow cytometry. | The reliable measurement of non-transferrin-bound iron (NTBI) in serum has proved to be difficult and generally time consuming. We have sought a simple and fast method for such a determination. We adopted a fluorescence assay and designed a fluorescent dye with a chelating agent attached to sense iron. To avoid autoflu... | 25,093,426 | [
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A Novel Approach to Realizing Routine HIV Screening and Enhancing Linkage to Care in the United States: Protocol of the FOCUS Program and Early Results. | The United States health care system remains far from implementing the Centers for Disease Control and Prevention's recommendation of routine human immunodeficiency virus (HIV) screening as part of health care for adults. Although consensus for the importance of screening has grown, innovations in implementing routine ... | 25,093,431 | [
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Classification of sequential swallowing types using videoendoscopy with high reproducibility and reliability. | This study aimed to classify sequential swallowing types using videoendoscopy (VE) avoiding radiation exposure and compare the results using videofluoroscopy (VF). Twenty-one healthy adults simultaneously underwent VF and VE during sequential straw drinking. Each discrete swallow was classified into an L-segmental type... | 25,093,442 | [
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Pharmacokinetics and toxicity predictors of new s-triazines, herbicide candidates, in correlation with chromatogrpahic retention constants. | Herbicides, which are ubiquitously present in soil and food, have been proven to cause human health hazard effects, hence development of new herbicide-active compounds is recommended. In this paper, nine 2,4-bis(cycloalkyl)-6-chloro-s-triazines were considered as herbicide candidates and their pharmacokinetics and toxi... | 25,093,448 | [
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Unambiguous Determination of the Absolute Configuration of Dimeric Stilbene Glucosides from the Rhizomes of Gnetum africanum. | Dimeric stilbene glucosides 1-3 [two diastereomers of (-)-gnemonoside A (1a and 1b), (-)-gnemonoside C (2), and (-)-gnemonoside D (3)] as well as a mixture of the two enantiomers of gnetin C (4) were isolated from the rhizomes of Gnetum africanum. The two enantiomers of gnetin C, (+)-4 and (-)-4, were obtained from the... | 25,093,453 | [
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In vitro study of a novel nanogold-collagen composite to enhance the mesenchymal stem cell behavior for vascular regeneration. | Novel nanocomposites based on type I collagen (Col) containing a small amount (17.4, 43.5, and 174 ppm) of gold nanoparticles (AuNPs, approximately 5 nm) were prepared in this study. The pure Col and Col-AuNP composites (Col-Au) were characterized by the UV-Vis spectroscopy (UV-Vis), surface-enhanced raman spectroscopy... | 25,093,502 | [
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-0.1069055,
-0.3989792,
-0.07050709,
-0.5782523,
-0.05812664,
-0.2704538,
0.04683188,
-0.1660654,
0.3032114,
0.03650631,
-0.03333359,
0.077958... |
Self-reported spatial hearing abilities across different cochlear implant profiles. | The goal of this study was to determine how self-reported spatial hearing abilities differ across various cochlear implant (CI) profiles and to examine the degree of subjective benefit following cochlear implantation across different groups of CI users. This was a retrospective study of subjective spatial hearing abili... | 25,093,507 | [
0.04388926,
0.1037502,
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0.06701788,
0.124760... |
Anterior Chamber Depth, Lens Thickness, and Related Measures in African American Females With Long Anterior Zonules: A Matched Study With Control for Refractive Error. | To investigate anterior chamber depth (ACD), lens thickness (LT), vitreous body length (VBL), and axial length (AL) in African American females with long anterior zonules (LAZ) while controlling for refractive error. The eyes of 50 African American females with LAZ were compared with 50 controls matched with age, race,... | 25,093,521 | [
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0.04350148,
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0.2232765,
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0.1686826,
0.1987244,
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0.08636165,
0.1900934,
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... |
Reminiscence functions and the health of Israeli Holocaust survivors as compared to other older Israelis and older Canadians. | Existing research with English-speaking samples indicates that various ways in which older adults recall their past affect both their physical and mental health. Self-positive reminiscence functions (i.e. identity, problem-solving, death preparation) correlate and predict mental health in later life whereas self-negati... | 25,093,526 | [
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0.05411101,
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0.3699869,
0.2025888,
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Interplay between longitudinal and transverse contrasts in Fe3O4 nanoplates with (111) exposed surfaces. | Iron oxide has been developed as either T1 or T2 magnetic resonance imaging (MRI) contrast agents by controlling the size and composition; however, the underlying mechanism of T1 and T2 contrasts in one iron oxide entity is still not well understood. Herein, we report that freestanding superparamagnetic magnetite nanop... | 25,093,532 | [
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0.09024391,
-0.15... |
Differentiation of bel-7402 human hepatocarcinoma cells induced by aqueous extracts of fresh gecko (AG) and its anti-tumor activity in vivo. | Gecko, a kind of reptile, has been widely used as a traditional Chinese medicine to treat various diseases including cancer in China for thousands of years. The aim of this study was to investigate the anti-tumor effect of AG (aqueous extracts of fresh gecko) on human hepatocellular carcinoma cell Bel-7402 in vitro and... | 25,093,547 | [
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0.1646739,
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0.1154467,
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0.5042333,
0.004423294,
-0.0641432,
-0.1422... |
2-Nitrophenol reduction promoted by S. putrefaciens 200 and biogenic ferrous iron: the role of different size-fractions of dissolved organic matter. | The reduction of nitroaromatic compounds (listed as a priority pollutant) in natural subsurface environments typically coexists with dissimilatory reduction of iron oxides effected by dissolved organic matter (DOM). Investigating the impact of the DOM that influences those reduction processes is crucial for understandi... | 25,093,552 | [
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0.2327798,
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0.3181263,
0.04723922,
0.07634383,
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0.1084336,
-0.182416... |
Morphogenesis: a Mob rules from the rear. | The giant ciliated protozoan Stentor coeruleus is re-emerging as a model organism for morphogenesis and patterning in unicellular organisms. A new study provides evidence that cytokinesis and morphogenesis are mechanistically linked through the Mob1 protein. | 25,093,564 | [
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0.07341631,
0.2011212,
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0.1508568,
0.1830524,
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Reproductive technology and the life course: current debates and research in social egg freezing. | While there are currently few confirmed births from previously frozen eggs in the UK, the improved outcomes of new technologies of vitrification and intra-cytoplasmic sperm injection (ICSI) have led to the marketing of egg freezing for non-medical reasons, whereby women are offered the possibility of preserving their e... | 25,093,571 | [
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-0.01952316,
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-0.2429518,
-0.1302842,
0.6829917,
-0.159... |
"Let's talk about sex": a qualitative study of Rwandan adolescents' views on sex and HIV. | This qualitative study explored the views and experiences of adolescents with perinatally acquired HIV in Kigali, Rwanda, regarding sex, love, marriage, children and hope for the future. The study enrolled 42 adolescents who had received combination antiretroviral therapy for at least 12 months, and a selection of thei... | 25,093,572 | [
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0.1775822,
0.0204861,
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0.1190408,
0.1701232,
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0.2553671,
0.3865137,
0.3458452,
-0.05865432,
0... |
Precipitation regime shift enhanced the rain pulse effect on soil respiration in a semi-arid steppe. | The effect of resource pulses, such as rainfall events, on soil respiration plays an important role in controlling grassland carbon balance, but how shifts in long-term precipitation regime regulate rain pulse effect on soil respiration is still unclear. We first quantified the influence of rainfall event on soil respi... | 25,093,573 | [
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0.007529811,
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0.1563717,
0.1878051,
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0.3609596,
-0.04665397,... |
Structural modeling of iron halogenases: synthesis and reactivity of halide-iron(IV)-oxo compounds. | A structural synthetic model of the iron(IV)-oxo-halide active species of non-heme iron dependent halogenases is reported. Compounds with general formula [Fe(IV)(O)(X)(Pytacn)](+) (1-X, X = Cl, Br) have been prepared and characterized spectroscopically and chemically with regard to their oxidizing ability. 1-X performs... | 25,093,575 | [
-0.2936893,
0.00483657,
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0.265312,
0.1532155,
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0.07076639,
0.004137607,
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0.03891923,
0.06414396,
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0.2616924,
0.1502519,
0.1297817,
0.2135168,
0.09978497,
-0.4046235,
... |
Use of the ADOS for assessing spontaneous expressive language in young children with ASD: a comparison of sampling contexts. | The current study compared the spontaneous expressive language of children with autism spectrum disorder (ASD) across multiple language sampling contexts: the Autism Diagnostic Observation Schedule (ADOS; Lord, Rutter, DiLavore, & Risi, 1999) and play with an examiner or parent. Participants were children with ASD ... | 25,093,577 | [
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0.3404652,
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0.3626252,
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0.1099728,
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0.08858503,
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0.250304,
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0.2560135,
0.06069928,
-0.2130293,
0.1842396,
-0.1634064,
-0.1382156,... |
Meta-analysis of operative mortality and complications in patients from minority ethnic groups. | Insight into the effects of ethnic disparities on patients' perioperative safety is necessary for the development of tailored improvement strategies. The aim of this study was to review the literature on safety differences between patients from minority ethnic groups and those from the ethnic majority undergoing surger... | 25,093,587 | [
-0.1874537,
-0.05518618,
-0.3962302,
-0.423872,
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0.02486224,
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0.03322478,
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0.3442441,
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0.4481776,
0.1227738,
-0.09529703,
0.01009224,
0.3703863,
0.03492531... |
Solvent reorganization plays a temperature-dependent role in antibiotic selection by a thermostable aminoglycoside nucleotidyltransferase-4'. | The aminoglycoside nucleotidyltransferase-4' (ANT) is an enzyme that causes resistance to a large number of aminoglycoside antibiotics by nucleotidylation of the 4'-site on these antibiotics. The effect of solvent reorganization on enzyme-ligand interactions was investigated using a thermophilic variant of the enzyme r... | 25,093,604 | [
0.1483277,
0.01575035,
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0.220524,
0.01731165,
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0.129899,
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0.5584391,
0.07300587,
0.232904,
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0.08352109,
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0.1515466,
0.2085624,
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0.00... |
Posttraumatic administration of luteolin protects mice from traumatic brain injury: implication of autophagy and inflammation. | Secondary brain insult induced by traumatic brain injury (TBI), including excitotoxicity, oxidative stress, inflammatory response, and neuronal degeneration, is sensitive to therapeutic interventions; therefore, searching for neuroprotective agents represents a promising therapeutic strategy for TBI treatment. Luteolin... | 25,093,609 | [
0.03581584,
0.1252688,
0.1708934,
0.03844517,
0.06909109,
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0.01510378,
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0.2380284,
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0.1428222,
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0.3535359,
0.1529218,
0.194332,
0.06751326,
-0... |
Estimating healthy life expectancies using longitudinal survey data: methods and techniques in population health measures. | Objective-Summary measures of population health are statistics that combine mortality and morbidity to represent overall population health in a single index. Such measures include healthy life expectancy, also called disability-free life expectancy and active life expectancy. Healthy life expectancy can be calculated u... | 25,093,608 | [
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0.0249953,
0.01053614,
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0.4041596,
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0.08464886,
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0.03772389,
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0.2297583,
0.4047711,
0.008097913,
... |
Human paraoxonase 1 hydrolysis of nanomolar chlorpyrifos-oxon concentrations is unaffected by phenotype or Q192R genotype. | The organophosphorus insecticide chlorpyrifos has been widely used. Its active metabolite chlorpyrifos-oxon (CPO) is a potent anticholinesterase and is detoxified by paraoxonase 1 (PON1). PON1 activity is influenced by numerous factors including a Q192R polymorphism. Using forty human blood samples bearing homozygous g... | 25,093,614 | [
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0.0311215,
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0.1561321,
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0.2349543,
-0.03854329,
0.5146565,
-0.1707401,
-... |
The polycystic ovary syndrome evolutionary paradox: a genome-wide association studies-based, in silico, evolutionary explanation. | Polycystic ovary syndrome (PCOS) is a common female endocrine disorder characterized by phenotypes ranging from hyperandrogenism to metabolic disorders, more prevalent in people of African/Caucasian and Asian ancestry. Because PCOS impairs fertility without diminishing in prevalence, it was considered an evolutionary p... | 25,093,623 | [
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0.2609645,
-0.2271727,
-0.341788,
0.1964538,
-0.235765... |
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