title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Critical comparison of sample preparation strategies for shotgun proteomic analysis of formalin-fixed, paraffin-embedded samples: insights from liver tissue. | The growing field of formalin-fixed paraffin-embedded (FFPE) tissue proteomics holds promise for improving translational research. Direct tissue trypsinization (DT) and protein extraction followed by in solution digestion (ISD) or filter-aided sample preparation (FASP) are the most common workflows for shotgun analysis... | 25,097,466 | [
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Knowledge and attitude of Saudi mothers towards their preschool children's oral health. | To determine knowledge and attitude of Saudi mothers towards their preschool children's oral health. One hundred and one mothers (of children aged 16 to 40 months) attending well-baby clinics at Security Forces Hospital Polyclinics in Makkah Al-Mukarrama participated in the study. A questionnaire was used to collect th... | 25,097,504 | [
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Effects of recombinant human growth hormone therapy on carbohydrate, lipid and protein metabolisms of children with Turner syndrome. | To study the effect of recombinant human growth hormone (rhGH) therapy on carbohydrate, lipid and protein metabolisms of Turner syndrome (TS). Metho d s: Total 45 patients with TS admitted between Jul. 2008 and Jun. 2011 were involved in this study. All patients received the clinical evaluation of body fat, plasma lipi... | 25,097,506 | [
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Bacterial contamination of the hands of food handlers as indicator of hand washing efficacy in some convenient food industries in South Africa. | Hands of ready-to-eat food service employees have been shown to be vectors in the spread of foodborne disease, mainly because of poor personal hygiene and accounting for approximately 97% of food borne illnesses in food service establishments and homes. Our objective was to evaluate the efficacy of hand washing practic... | 25,097,511 | [
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Comparison of levonorgestrel-releasing intrauterine device with oral progestins in heavy menstrual bleeding (HMB) cases with uterine leiomyoma (LNG-IUD and oral progestin usage in myoma uteri). | To compare the effectiveness and acceptability of LNG-IUD with oral progesterone (norethisterone acetate; NETA) in achieving a reduction in volume of the myomas, hemoglobin levels, satisfaction of the women. This study includes randomized 30 women treated by LNG-IUD and randomized 30 women treated by oral norethisteron... | 25,097,527 | [
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Clinical therapeutic effects of AO/ASIF clavicle hook plate on distal clavicle fractures and acromioclavicular joint dislocations. | The aim of this study was to evaluate the security and effectiveness of AO/ASIF clavicle hook plate in the treatment of distal clavicle fractures and acromioclavicular joint dislocations. One hundred patients with distal clavicle fractures and acromioclavicular joint dislocations who were admitted in our hospital from ... | 25,097,534 | [
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Paecilomyces lilacinus fungaemia in an AIDS patient: the importance of mycological diagnosis. | Fungaemia due to Paecilomyces lilacinus is generally not considered in AIDS patients because this condition is not categorised as an AIDS-indicator illness. We report a case of a 25-year-old lady who presented to our hospital with Guillain-Barré Syndrome, with the subsequent development of refractory fungaemia, multi-o... | 25,097,544 | [
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Bladder preservation with brachytherapy compared to cystectomy for T1-T3 muscle-invasive bladder cancer: a systematic review. | Radical cystectomy currently is the treatment of choice in muscle-invasive bladder cancer. However, cystectomy is associated with considerable morbidity. Bladder sparing treatment consists of transurethral resection of the tumor (with or without partial cystectomy), external beam radiotherapy, and brachytherapy. The pu... | 25,097,561 | [
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Dose estimation for different skin models in interstitial breast brachytherapy. | Skin is a major organ at risk in breast-conserving therapy (BCT). The American Brachytherapy Society (ABS) recommendations require monitoring of maximum dose received, however, there is no unambiguous way of skin contouring provided. The purpose of this study was to compare the doses received by the skin in different m... | 25,097,562 | [
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The long head of the biceps tendon is a suitable cell source for tendon tissue regeneration. | Tendon tissue engineering (TTE) tries to produce tendinous tissue of high quality to replace dysfunctional tissue. One possible application of TTE might be the replacement of ruptured tissue of the rotator cuff. Autologous tenocytes seem to be most suitable as no differentiation in vitro is necessary. Today it is still... | 25,097,592 | [
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Comparison of postoperative bleeding between submucosal uvulopalatopharyngoplasty and tonsillectomy. | The aim of this study was to compare the incidence of postoperative secondary hemorrhage for tonsillectomy and submucosal uvulopalatopharyngoplasty (smUPPP). In this retrospective case series, the medical records of 404 patients who underwent tonsillectomy with unipolar electrocautery and smUPPP at our institution betw... | 25,097,602 | [
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Oxidative stress and hypertension: Possibility of hypertension therapy with antioxidants. | Hypertension is a major risk factor for myocardial infarction, heart failure, stroke, peripheral arterial disease, and aortic aneurysm, and is a cause of chronic kidney disease. Hypertension is often associated with metabolic abnormalities such as diabetes and dyslipidemia, and the rate of these diseases is increasing ... | 25,097,610 | [
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Cystatin C, N-terminal probrain natriuretic peptides and outcomes in acute heart failure with acute kidney injury in a 12-month follow-up: Insights into the cardiorenal syndrome. | Cystatin C (Cys C) has been implicated as a prognostic marker in cardiovascular disease. The aim of this study was to evaluate the value of Cys C as a marker of acute kidney injury (AKI) in acute heart failure (AHF), the impact of Cys C and N-terminal probrain natriuretic peptides (NT-proBNP) on in-hospital and 12 mont... | 25,097,621 | [
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When to suspect head injury or cervical spine injury in maxillofacial trauma? | The global status report of the World Health Organization (WHO) on road safety suggested that India is leading in road traffic accidents in the world. According to the report on road accidents in India in 2010 by the Transport Research Wing, Ministry of Road Transport and Highways, New Delhi, Kerala ranked third in acc... | 25,097,643 | [
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Endometrial stem cells in regenerative medicine. | First described in 2004, endometrial stem cells (EnSCs) are adult stem cells isolated from the endometrial tissue. EnSCs comprise of a population of epithelial stem cells, mesenchymal stem cells, and side population stem cells. When secreted in the menstrual blood, they are termed menstrual stem cells or endometrial re... | 25,097,665 | [
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Associated features in females with an FMR1 premutation. | Changes in the fragile X mental retardation 1 gene (FMR1) have been associated with specific phenotypes, most specifically those of fragile X syndrome (FXS), fragile X tremor/ataxia syndrome (FXTAS), and fragile X primary ovarian insufficiency (FXPOI). Evidence of increased risk for additional medical, psychiatric, and... | 25,097,672 | [
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Laparoscopic treatment of type III and IV hiatal hernia - authors' experience. | There are four types of hiatal hernias, and diagnosis is established on the basis of gastroscopy in the majority of cases. Type III represents a mixed type in which the abdominal esophagus as well as the gastric cardia and fundus protrude into the thorax through the pathologically widened esophageal hiatus. Type IV, th... | 25,097,681 | [
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Minimally invasive procedures in severe acute pancreatitis treatment - assessment of benefits and possibilities of use. | Acute pancreatitis (AP) consists of an extremely varied complex of pathological symptoms and clinical conditions, ranging from mild gastric complaints to multi-organ failure resulting in death. To present the authors' own experience regarding surgical treatment for pancreatic necrosis complicated by infection using dif... | 25,097,683 | [
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Comparison of hysterosalpingography and transvaginal hydrolaparoscopy in patients with tubal factor infertility: a prospective cohort study. | To evaluate the usefulness, diagnostic accuracy, and cost-effectiveness of transvaginal hydrolaparoscopy (THL) in infertile women with abnormal hysterosalpingogram (HSG) results without obvious pelvic pathology. THIRTY INFERTILE WOMEN (AGE: 20-40 years) who had tubal pathology in HSG were enrolled in the study. All pat... | 25,097,685 | [
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Single incision approach to totally extraperitoneal inguinal hernia repair. | Nowadays the vast majority of inguinal hernia repairs are laparoscopically assisted. Single incision laparoscopy aims to accelerate recovery and provide a better cosmetic outcome after the operation. To present our own modification of the totally extraperitoneal (TEP) procedure with a single incision and without a mult... | 25,097,687 | [
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Superficial plane endoscopy for carpal tunnel release. | In this publication we describe three techniques for endoscopic carpal tunnel release which use the palmar portal approach and the superficial plane to enable a view from above the transverse carpal ligament. These techniques prevent any iatrogenic compression of the median nerve inside the already narrow tunnel. Altho... | 25,097,697 | [
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Comparison of visualization of the middle ear by microscope and endoscopes of 30° and 45° through posterior tympanotomy. | Endoscopic-assisted microsurgery of the middle ear enables the field of view of the surgeon to be expanded during the removal of inflammatory tissue from the tympanic cavity and during myringo- and ossiculoplasty. Canal wall up tympanoplasty with posterior tympanotomy is a gold standard in surgical treatment of chronic... | 25,097,700 | [
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Prevalence and triggers of allergic rhinitis in the United Arab Emirates. | Allergic rhinitis is a morbid condition that is frequently overlooked by patients and physicians. This type of atopy has not been adequately investigated in the United Arab Emirates. This cross-sectional, population-based observational study was conducted in the seven Emirates (Abu Dhabi, Dubai, Sharjah, Ajman, Umm Al-... | 25,097,721 | [
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Stem cell delivery of therapies for brain disorders. | The blood brain barrier (BBB) poses a problem to deliver drugs for brain malignancies and neurodegenerative disorders. Stem cells such as neural stem cells (NSCs) and mesenchymal stem cells (MSCs) can be used to delivery drugs or RNA to the brain. This use of methods to bypass the hurdles of delivering drugs across the... | 25,097,727 | [
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Chemotherapy induced peripheral neuropathic pain. | Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most serious complications associated with anticancer drugs. CIPN leads to a lower quality of life and dysfunction of the sensory, motor, and autonomic systems, and often causes patients to discontinue chemotherapy. It is usually misdiagnosed and undertrea... | 25,097,731 | [
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Partially unroofed coronary sinus with persistent left superior vena cava: the utility of two and three-dimensional transesophageal echocardiography: a case report. | Unroofed coronary sinus (URCS) is a rare cardiac anomaly, in which communication occurs between the coronary sinus (CS) and the left atrium (LA) because of partial or complete absence of the CS roof. A 30-year-old woman was scheduled for surgical closure of atrial septal defect, mitral valve repair and tricuspid annulo... | 25,097,740 | [
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Critical transitions in a game theoretic model of tumour metabolism. | Tumour proliferation is promoted by an intratumoral metabolic symbiosis in which lactate from stromal cells fuels energy generation in the oxygenated domain of the tumour. Furthermore, empirical data show that tumour cells adopt an intermediate metabolic state between lactate respiration and glycolysis. This study mode... | 25,097,747 | [
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Prevalence and Pattern of Third Molar Impaction: A retrospective study of radiographs in Oman. | The aim of this retrospective study was to investigate the prevalence and pattern of third molar impaction in patients between 19-26 years old attending Sultan Qaboos University Hospital (SQUH) in Muscat, Oman. The study reviewed 1,000 orthopantomograms (OPGs) of patients attending the Oral Health Department of SQUH be... | 25,097,776 | [
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Mycoplasma agalactiae, an Etiological Agent of Contagious Agalactia in Small Ruminants: A Review. | Mycoplasma agalactiae is one of the causal agents of classical contagious agalactia (CA), a serious, economically important but neglected enzootic disease of small ruminants. It occurs in many parts of the world and most notably in the Mediterranean Basin. Following the infection common complications are septicaemia, m... | 25,097,796 | [
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Prospective assessment of a score for assessing basic critical-care transthoracic echocardiography skills in ventilated critically ill patients. | We studied a score for assessing basic transthoracic echocardiography (TTE) skills exhibited by residents who examined critically ill patients receiving mechanical ventilation. We conducted a prospective study in the 16 residents who worked in our medical-surgical ICU between 1 May 2008 and 1 November 2009. The residen... | 25,097,797 | [
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Involvement of cortical midline structures in the processing of autobiographical information. | The term autobiographical self has been used to refer to a mental state that permits reflection on self-identity and personality and the answer to related questions (Damasio, 1998). It requires the retrieval and integrated assembly of memories of facts and events that define an individual's biography. The neural mechan... | 25,097,820 | [
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MicroRNAs in Cholangiopathies. | Cholangiocytes, the cells lining bile ducts, comprise a small fraction of the total cellular component of the liver, yet perform the essential role of bile modification and transport of biliary and blood constituents. Cholangiopathies are a diverse group of biliary disorders with the cholangiocyte as the target cell; t... | 25,097,819 | [
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Galectins in epithelial functions. | Galectins are a family of animal lectins comprising 15 members in vertebrates. These proteins are involved in many biological processes including epithelial homeostasis and tumor progression by displaying intracellular and extracellular activities. Hence Galectins can be found either in the cytoplasm or the nucleus, as... | 25,097,826 | [
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Augmented plasma adiponectin after prolonged fasting during ramadan in men. | Intermittent fasting during Ramadan entails major changes in metabolism and energy expenditure. This study sought to determine effect of the Ramadan fasting on serum levels of adiponectin and tumor necrosis factor-α (TNF-α) as two inter-related peptides involved in cells sensitivity to insulin and glucose metabolism. T... | 25,097,840 | [
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Effects of presowing pulsed electromagnetic treatment of tomato seed on growth, yield, and lycopene content. | The use of magnetic field as a presowing treatment has been adopted by researchers as a new environmental friendly technique. The aim of this study was to determine the effect of magnetic field exposure on tomato seeds covering a range of parameters such as transplanting percentage, plant height, shoot diameter, number... | 25,097,875 | [
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Effect of damping and yielding on the seismic response of 3D steel buildings with PMRF. | The effect of viscous damping and yielding, on the reduction of the seismic responses of steel buildings modeled as three-dimensional (3D) complex multidegree of freedom (MDOF) systems, is studied. The reduction produced by damping may be larger or smaller than that of yielding. This reduction can significantly vary fr... | 25,097,892 | [
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[The effect of enzymatic treatment using proteases on properties of persistent sodium current in CA1 pyramidal neurons of rat hippocampus]. | We investigated the effect of proteases, widely used for neuron isolation in electrophysiological studies, on the amplitude and kinetic characteristics of persistent sodium current (I(NaP)) in hippocampal CA1 pyramidal neurons. Properties of I(NaP) were studied on neurons isolated by mechanical treatment (control group... | 25,097,934 | [
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[Endoscopic transpapillary interventions in chronic pancreatitis]. | The results of treatment of 12 patients, suffering complicated forms of chronic pancreatitis (CHP), in a General Surgery Department of Ivano-Frankivsk regional clinical hospital in 2011 - 2013 yrs, were analyzed. There were 10 (83.3%) men and 2 (16.7%) women, ageing 22-57 yrs old. Previously 6 (50%) patients were treat... | 25,097,992 | [
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Quality physical education: a commentary on effective physical education teaching. | In my commentary in response to the 3 articles (McKenzie & Lounsbery, 2013; Rink, 2013; Ward, 2013), I focus on 3 areas: (a) content knowledge, (b) a holistic approach to physical education, and (c) policy impact. I use the term quality teaching rather than "teacher effectiveness." Quality teaching is a term with t... | 25,098,010 | [
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Effect of taurocholic acid on fetoplacental arterial pressures in a dual perfusion placental cotyledon model: a novel approach to intrahepatic cholestasis of pregnancy. | To determine if continuous infusion of taurocholic acid into the fetoplacental and intervillous circulation of a placental cotyledon affects the fetal arterial pressure response after injection of the thromboxane mimetic U44619. Taurine conjugated bile acid is one bile acid putatively mediating intrahepatic cholestasis... | 25,098,026 | [
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Inadvertent vaginal entry during cesarean delivery: a report of two cases. | Inadvertent vaginal entry is a rare intraoperative complication that may occur during cesarean deliveries performed in advanced labor or during emergency cesarean deliveries. We report two cases of inadvertent vaginal entry complicating cesarean delivre eries. The first cesarean delivery was performed after prolonged s... | 25,098,037 | [
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Presentation of maxillofacial injuries in the 2005 earthquake victims. | Earthquakes cause a lot of damage to life and property. Maxillofacial injuries constitute an important proportion of injuries in earthquakes and some 13% of the trauma patients after the earthquakes suffer from maxillofacial injuries. The objective of this study was to assess the presentation of maxillofacial injuries ... | 25,098,040 | [
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Risk factors for stroke: a prospective hospital based study. | The stroke is third leading cause of death in world and most patients die with an acute event in stroke. Various clinical variables have been investigated as risks factors of stroke. The study was aimed to identify these risks factors for stroke. This prospective study included 205 consecutive patients of stroke admitt... | 25,098,044 | [
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Pap smear, an important screening tool to detect precancerous stage of carcinoma of cervix. | Many women can be saved from carcinoma of cervix by detecting and treating its precancerous stage. Pap smear is cheap and easily available in majority of institutes. The objective of this study is to determine the frequency of abnormal Pap smear and role of Pap smear in detecting precancerous stage of cancer cervix in ... | 25,098,046 | [
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Delay in diagnosis and treatment of benign paroxysmal positional vertigo in current practice. | More than 50% of the patients with peripheral vestibular disorders are suffering from Benign Paroxysmal Positional Vertigo (BPPV). Diagnosis is established by positive Dix-Halpike test and/or roll test. Objective of this study was to analyse the delay in diagnosis and treatment of BPPV in current practice and to sugges... | 25,098,065 | [
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Nutritional status of primary school children in Abbottabad. | In Abbottabad district, with the vast poverty stricken rural majority and 80% literacy rate, primary-level education faces great influx of students. This study was carried out to see the nutritional status of children 5-10 years of age attending primary schools of Abbottabad. This was a descriptive, cross-sectional stu... | 25,098,074 | [
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Awareness regarding obesity amongst general physicians of Karachi. | Obesity is considered a disease and one of the fastest growing global threats. In Pakistan General Physicians (GPs) are approached first in case of any disease thus their knowledge and practices regarding obesity are very important to assess. Our objective was to assess the knowledge and practices of GPs regarding obes... | 25,098,078 | [
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Reasons for failure of exclusive breastfeeding in children less than six months of age. | Human milk is the natural food for full term infants and is the most appropriate milk for the human infants. The objective of the study was to determine the frequency of common reasons of failure of exclusive breastfeeding in children less than six months of age. It was a cross-sectional study conducted at Rawal instit... | 25,098,086 | [
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Role of cranial computed tomography in predicting clinical outcome in patients with minor head injury. | Optimal management of patients with mild head injury in the emergency department is still under debate. The objective of this study was to determine the diagnostic efficacy of computed tomography in patients with minor head injury. A cross-sectional comparative study was conducted in the Radiology department of PIMS, I... | 25,098,092 | [
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[Penetrating keratoplasty in high-risk children: prevention of graft rejection]. | To evaluate the efficacy of prolonged courses of systemically administered subtherapeutic Metipred and cyclosporine in prevention of graft rejection in high-risk children. The study included 27 children at high risk of graft rejection due to re-keratoplasty (n = 8), limbo-keratoplasty for corneal staphyloma (n = 4), or... | 25,098,116 | [
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[The characteristics of and social support for pathological gamblers among "pachinko" or "slot" users in Japan]. | In Japan, there are one to two million people suspected of being pathological gamblers according to the definition in DSM-IV-TR. Almost all of them use "pachinko" or "slot," which are gambling stores, throughout Japan, that number 12,000 in total. However, the characteristics and ratio of pathological "pachinko" and "s... | 25,098,151 | [
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[The therapeutic structure and clinical staff skills that is needed for establishing the community-based treatment of the people with schizophrenia: the short report of recent reform process of "day care" and outreach team in National Center of Neurology and Psychiatry]. | As aging and disease structure has changed mainly in accordance with adult disease, general medical treatment has been expected to take a role as a part of the"Comprehensive Care" that contributes to improve the quality of life. The similar paradigm change is needed for the treatment for the people with severe mental i... | 25,098,155 | [
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Seeing life through positive-tinted glasses: color-meaning associations. | There is a growing body of literature to show that color can convey information, owing to its emotionally meaningful associations. Most research so far has focused on negative hue-meaning associations (e.g., red) with the exception of the positive aspects associated with green. We therefore set out to investigate the p... | 25,098,167 | [
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Impact of centralising acute stroke services in English metropolitan areas on mortality and length of hospital stay: difference-in-differences analysis. | To investigate whether centralisation of acute stroke services in two metropolitan areas of England was associated with changes in mortality and length of hospital stay. Analysis of difference-in-differences between regions with patient level data from the hospital episode statistics database linked to mortality data s... | 25,098,169 | [
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Seasonal variation of serum KL-6 concentrations is greater in patients with hypersensitivity pneumonitis. | Serum KL-6 is a useful biomarker for the diagnosis of interstitial lung diseases (ILD). However, KL-6 has not been used to discriminate different types of ILD. Serum KL-6 concentrations can vary depending on antigen exposure levels in patients with hypersensitivity pneumonitis (HP); however, seasonal changes in serum K... | 25,098,177 | [
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Pretreatment of human cerebrovascular endothelial cells with CO-releasing molecule-3 interferes with JNK/AP-1 signaling and suppresses LPS-induced proadhesive phenotype. | Exogenously administered CO interferes with PMN recruitment to the inflamed organs. The mechanisms of CO-dependent modulation of vascular proadhesive phenotype, a key step in PMN recruitment, are unclear. We assessed the effects/mechanisms of CO liberated from a water-soluble CORM-3 on modulation of the proadhesive phe... | 25,098,198 | [
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Percutaneous mitral heart valve repair--MitraClip. | Mitral regurgitation (MR) is the most common cardiac valvular disease in the United States. Approximately 4 million people have severe MR and roughly 250,000 new diagnoses of MR are made each year. Mitral valve surgery is the only treatment that prevents progression of heart failure and provides sustained symptomatic r... | 25,098,200 | [
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Appearance-based multimodal human tracking and identification for healthcare in the digital home. | There is an urgent need for intelligent home surveillance systems to provide home security, monitor health conditions, and detect emergencies of family members. One of the fundamental problems to realize the power of these intelligent services is how to detect, track, and identify people at home. Compared to RFID tags ... | 25,098,207 | [
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Dual-element transducer with phase-inversion for wide depth of field in high-frequency ultrasound imaging. | In high frequency ultrasound imaging (HFUI), the quality of focusing is deeply related to the length of the depth of field (DOF). In this paper, a phase-inversion technique implemented by a dual-element transducer is proposed to enlarge the DOF. The performance of the proposed method was numerically demonstrated by usi... | 25,098,208 | [
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[Genetic mutations and the relationship with clinical phenotype in patients with mucopolysaccharidosis type I in northeast Mexico]. | The mutations found in the IDUA gene depend on racial and genetic background. The aim of this paper is to determine the mutations of the IDUA gene in patients with MPS I in the Northeast of Mexico and the relationship with phenotype. Molecular studies were performed in seven patients from Nuevo Leon with MPS I. Five pa... | 25,098,213 | [
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NMR Structure Elucidation of Small Organic Molecules and Natural Products: Choosing ADEQUATE vs HMBC. | Long-range heteronuclear shift correlation methods have served as the cornerstone of modern structure elucidation protocols for several decades. The (1)H-(13)C HMBC experiment provides a versatile and relatively sensitive means of establishing predominantly (3)J(CH) connectivity with the occasional (2)J(CH) or (4)J(CH)... | 25,098,228 | [
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Understanding the CD28/CTLA-4 (CD152) pathway and its implications for costimulatory blockade. | T cell activation is a key event in the adaptive immune system and vital in the generation of protective cellular and humoral immunity. Activation is required to generate CD4 effector T cell responses and provide help for B cell and cytotoxic T cell responses. While defective T responses to foreign antigen result in in... | 25,098,238 | [
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Combination treatment with Gua Sha and Blood-letting causes attenuation of systemic inflammation, activated coagulation, tissue ischemia and injury during heatstroke in rats. | Gua Sha and Blood-letting at the acupoints were Chinese traditional therapies for heatstroke. The purpose of present study was to assess the therapeutic effect of Gua Sha on the DU Meridian and Bladder Meridian combined with Blood-letting acupoints at Shixuan (EX-UE 11) and Weizhong (BL 40) on heatstroke. Anesthetized ... | 25,098,257 | [
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The functional basis of adaptive evolution in chemostats. | Two of the central problems in biology are determining the molecular basis of adaptive evolution and understanding how cells regulate their growth. The chemostat is a device for culturing cells that provides great utility in tackling both of these problems: it enables precise control of the selective pressure under whi... | 25,098,268 | [
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Adverse events in cancer genetic testing: the third case series. | After repeated media attention in 2013 due to the Angelina Jolie disclosure and the Supreme Court decision to ban gene patents, the demand for cancer genetic counseling and testing services has never been greater. Debate has arisen regarding who should provide such services and the quality of genetics services being of... | 25,098,283 | [
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The immunotherapeutic role of regulatory T cells in Leishmania (Viannia) panamensis infection. | Leishmania (Viannia) parasites are etiological agents of cutaneous leishmaniasis in the New World. Infection is characterized by a mixed Th1/Th2 inflammatory response, which contributes to disease pathology. However, the role of regulatory T cells (Tregs) in Leishmania (Viannia) disease pathogenesis is unclear. Using t... | 25,098,291 | [
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Fatal paralytic shellfish poisoning in Kittlitz's Murrelet (Brachyramphus brevirostris) nestlings, Alaska, USA. | Paralytic shellfish poisoning (PSP) is an acute toxic illness in humans resulting from ingestion of shellfish contaminated with a suite of neurotoxins (saxitoxins) produced by marine dinoflagellates, most commonly in the genus Alexandrium. Poisoning also has been sporadically suspected and, less often, documented in ma... | 25,098,307 | [
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Genotoxic Maillard byproducts in current phytopharmaceutical preparations of Echinodorus grandiflorus. | Extracts of Echinodorus grandiflorus obtained from dried leaves by three different techniques were evaluated by bacterial lysogenic induction assay (Inductest) in relation to their genotoxic properties. Before being added to test cultures, extracts were sterilized either by steam sterilization or ultraviolet light. Onl... | 25,098,311 | [
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Effectiveness of the Assessment of Burden of Chronic Obstructive Pulmonary Disease (ABC) tool: study protocol of a cluster randomised trial in primary and secondary care. | Chronic Obstructive Pulmonary Disease (COPD) is a growing worldwide problem that imposes a great burden on the daily life of patients. Since there is no cure, the goal of treating COPD is to maintain or improve quality of life. We have developed a new tool, the Assessment of Burden of COPD (ABC) tool, to assess and vis... | 25,098,313 | [
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Smartphone ownership and interest in mobile applications to monitor symptoms of mental health conditions. | Patient retrospective recollection is a mainstay of assessing symptoms in mental health and psychiatry. However, evidence suggests that these retrospective recollections may not be as accurate as data collection though the experience sampling method (ESM), which captures patient data in "real time" and "real life." How... | 25,098,314 | [
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Donation after circulatory death: a national survey of current practice in England in 2012. | In recent years, England has seen renewed interest in donation after circulatory death. Many national and local initiatives have been implemented to encourage and support donation after circulatory death. To assess whether practice is in line with published guidance, we conducted a national survey with regard to curren... | 25,098,334 | [
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An update on leptin as immunomodulator. | Until the discovery of leptin 20 years ago, adipose tissue was considered only as a fat storage organ, involved in the regulation of energy homeostasis. At present, it is well known that adipokines, being leptin the forerunner of this superfamily, may act in different biological processes, including inflammation and im... | 25,098,336 | [
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Diagnostic values for skin temperature assessment to detect diabetes-related foot complications. | Skin temperature assessment is a promising modality for early detection of diabetic foot problems, but its diagnostic value has not been studied. Our aims were to investigate the diagnostic value of different cutoff skin temperature values for detecting diabetes-related foot complications such as ulceration, infection,... | 25,098,361 | [
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L-Leucine improves the anaemia in models of Diamond Blackfan anaemia and the 5q- syndrome in a TP53-independent way. | Haploinsufficiency of ribosomal proteins (RPs) and upregulation of the tumour suppressor TP53 have been shown to be the common basis for the anaemia observed in Diamond Blackfan anaemia and 5q- myelodysplastic syndrome. We previously demonstrated that treatment with L-Leucine resulted in a marked improvement in anaemia... | 25,098,371 | [
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Investigation into the role of potentially contaminated feed as a source of the first-detected outbreaks of porcine epidemic diarrhea in Canada. | In January 2014, approximately 9 months following the initial detection of porcine epidemic diarrhea (PED) in the USA, the first case of PED was confirmed in a swine herd in south-western Ontario. A follow-up epidemiological investigation carried out on the initial and 10 subsequent Ontario PED cases pointed to feed as... | 25,098,383 | [
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Structural properties of dense hard sphere packings. | We numerically study structural properties of mechanically stable packings of hard spheres (HS), in a wide range of packing fractions 0.53 ≤ ϕ ≤ 0.72. Detailed structural information is obtained from the analysis of orientational order parameters, which clearly reveals a disorder-order phase transition at the random cl... | 25,098,389 | [
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Oolong, black and pu-erh tea suppresses adiposity in mice via activation of AMP-activated protein kinase. | It is well known that tea has a variety of beneficial impacts on human health, including anti-obesity effects. It is well documented that green tea and its constituent catechins suppress obesity, but the effects of other types of tea on obesity and the potential mechanisms involved are not yet fully understood. In this... | 25,098,399 | [
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Role of water in protein folding, oligomerization, amyloidosis and miniprotein. | The essential involvement of water in most fundamental extra-cellular and intracellular processes of proteins is critically reviewed and evaluated in this article. The role of water in protein behavior displays structural ambivalence; it can protect the disordered peptide-chain by hydration or helps the globular chain-... | 25,098,401 | [
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Transcriptome-wide analysis of WRKY transcription factors in wheat and their leaf rust responsive expression profiling. | WRKY, a plant-specific transcription factor family, has important roles in pathogen defense, abiotic cues and phytohormone signaling, yet little is known about their roles and molecular mechanism of function in response to rust diseases in wheat. We identified 100 TaWRKY sequences using wheat Expressed Sequence Tag dat... | 25,098,419 | [
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Severe Oculofacial Sequelae of Cutaneous Blastomyces dermatitidis. | This study reports a case of Blastomyces dermatitidis soft tissue infection resulting in a disfiguring lower eyelid ectropion from cicatricial and postinflammatory cutaneous changes. Primary treatment included intravenous amphotericin B followed by long-term oral itraconazole, which resulted in complete remission of th... | 25,098,446 | [
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[Ultrasound-guided renal biopsy: evaluation of different models of biological simulator]. | Percutaneous ultrasound-guided renal biopsy is the gold standard for diagnosis and treatment of renal diseases. Recently, many studies strongly support the role of renal biopsy for the management of small renal mass. The experience of the operator is crucial in reducing the incidence of major complications. The use of ... | 25,098,459 | [
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[Marketing in health service]. | The gradual emergence of marketing activities in public health demonstrates an increased interest in this discipline, despite the lack of an adequate and universally recognized theoretical model. For a correct approach to marketing techniques, it is opportune to start from the health service, meant as a service rendere... | 25,098,468 | [
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... |
[Low protein dinner: patients in the kitchen]. | Diet therapy is important in renal failure to slow down the progression of the nephropathy and to control uremic symptoms. The main barrier is long-term poor compliance because of flavour and appetizing of a low protein meal. We organized an educational cooking event in a kitchen laboratory with a chef.Fifty patients c... | 25,098,470 | [
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0.1079399,
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0.03530233,
0.1622492,
0.02290274,
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Evaluation of the Ryegrass Stem Rust Model STEMRUST_G and Its Implementation as a Decision Aid. | STEMRUST_G, a simulation model for epidemics of stem rust in perennial ryegrass grown to maturity as a seed crop, was validated for use as a heuristic tool and as a decision aid for disease management with fungicides. Multistage validation had been used in model creation by incorporating previously validated submodels ... | 25,098,496 | [
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0.2334719,
0.2445101,
0.06152033,
0.209433,
0.4097907,
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0.256... |
Validating the three-step return-to-play decision model. | The purpose of this study was to validate a recently proposed return-to-play (RTP) decision model that simplifies the complex process into three underlying constructs: injury type and severity, sport injury risk, and factors unrelated to injury risk (decision modifiers). We used a cross-over design and provided clinica... | 25,098,497 | [
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0.07399599,
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0.2493773,
-0.08035... |
Negative/positive home-based caregiving appraisals by informal carers of the elderly in Japan. | This study aimed to determine factors associated with negative/positive home-based caregiving appraisals by informal carers of older people in Japan to consider which family carers' community health nurses should focus on. Because of the increasing older population in Japan, those needing a high level of care have beco... | 25,098,529 | [
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0.06874398,
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Evaluation of influence of chronic kidney disease and sodium disturbances on clinical course of acute and sub-acute stage first-ever ischemic stroke. | Chronic kidney disease (CKD) is an independent risk factor for cardiovascular morbidity and mortality. Hyponatremia is the most common electrolyte disturbance encountered in the neurological and neurosurgical intensive care units, and can exacerbate existing neurological deficits. The objective of this study was to obs... | 25,098,531 | [
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0.0626847,
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Contribution of ATXN2 intermediary polyQ expansions in a spectrum of neurodegenerative disorders. | The aim of this study was to establish the frequency of ATXN2 polyglutamine (polyQ) expansion in large cohorts of patients with amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and progressive supranuclear palsy (PSP), and to evaluate whether ATXN2 could act as a modifier gene in patients carrying th... | 25,098,532 | [
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0.2654853,
0.03727883,
0.3570259,
0.2316927,
0.07612949,
... |
Vitamin D and the risk of dementia and Alzheimer disease. | To determine whether low vitamin D concentrations are associated with an increased risk of incident all-cause dementia and Alzheimer disease. One thousand six hundred fifty-eight elderly ambulatory adults free from dementia, cardiovascular disease, and stroke who participated in the US population-based Cardiovascular H... | 25,098,535 | [
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0.002929306,
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0.2619098,
0.02634901,
0.07400899,
0.08052245,
0.3266693,
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CT angiography spot sign in intracerebral hemorrhage predicts active bleeding during surgery. | To determine whether the CT angiography (CTA) spot sign marks bleeding complications during and after surgery for spontaneous intracerebral hemorrhage (ICH). In a 2-center study of consecutive spontaneous ICH patients who underwent CTA followed by surgical hematoma evacuation, 2 experienced readers (blinded to clinical... | 25,098,540 | [
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0.363754,
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0.04344762,
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0.1539833,
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0.005136134,
0.05157,
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0.0... |
Bifunctional DNA architectonics: three-way junctions with sticky perylene bisimide caps and a central metal lock. | A new type of a bifunctional DNA architecture based on a three way junction is developed that combines the structural motif of sticky perylene bisimide caps with a tris-bipyridyl metal ion lock in the center part. A clear stabilizing effect was observed in the presence of Fe(3+), Ni(2+) and Zn(2+) by the formation of c... | 25,098,549 | [
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0.4629051,
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0.06980689,
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0.2393016,
0.4234486,
0.1763796,
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0.... |
Comparison of location, depth, quality, and intensity of experimentally induced pain in 6 low back muscles. | The pattern of pain originating from experimentally induced low back pain appears diffuse. This may be because sensory information from low back muscles converges, sensory innervation extends over multiple vertebral levels, or people have difficulty accurately representing the painful location on standardized pain maps... | 25,098,553 | [
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0.03899132,
0.1677491,
0.136593... |
Acinetobacter apis sp. nov., isolated from the intestinal tract of a honey bee, Apis mellifera. | A novel Gram-negative, obligate aerobic, non-motile, and both coccobacillus- and bacillus-shaped bacterium, designated strain HYN18(T), was isolated from the intestinal tract of a honey bee (Apis mellifera). The isolate was oxidase-negative and catalase-positive. Strain HYN18(T) showed optimum growth at 25°C, pH 6-7, a... | 25,098,562 | [
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0.3546741,
0.02608676,
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0.1000915,
0.1214086,
0.183458... |
The sphenoid sinus: an unusual presentation of a typical carcinoid tumor. | Carcinoid tumors are neuroendocrine tumors that are most commonly found in the gastrointestinal tracts and lungs. They seldom develop in the head and neck area as a primary tumor, and there have been rare reports of them arising in the sinonasal area. We report a case of a 47-year-old woman with a typical carcinoid tum... | 25,098,581 | [
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0.323031,
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0.3272541,
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0.1467294,
0.1333091,
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Clinical presentation of intralabyrinthine schwannomas: a multicenter study of 110 cases. | To describe the presentation of intralabyrinthine schwannomas (ILSs). Retrospective multicenter study involving 12 European skull base surgery tertiary referral centers. One hundred ten patients with the diagnosis of ILS, either labyrinth confined or extending into the internal auditory meatus for less than 50% of thei... | 25,098,591 | [
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0.06012499,
0.1360059,
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0.3067594,
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0.3353251,
0.1391464,
-0.08578772,... |
How to support the needs of mothers with physical disabilities? | The objectives of this study were: (1) to understand and describe the challenges that women with physical disabilities face during their motherhood process; (2) to understand and describe their strengths, and (3) to produce a list of supports that health professionals and policy makers should apply in order to address ... | 25,098,594 | [
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0.1189155,
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-0.2990789,
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-0.4744886,
0.1844572,
-0.5242179,
-0.07636382,
-0.09658346,
-0.07762016,
-0.17839... |
Integrated control of Na transport along the nephron. | The kidney filters vast quantities of Na at the glomerulus but excretes a very small fraction of this Na in the final urine. Although almost every nephron segment participates in the reabsorption of Na in the normal kidney, the proximal segments (from the glomerulus to the macula densa) and the distal segments (past th... | 25,098,598 | [
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0.03596123,
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0.269578,
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0.1144923,
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-0.04845277,
0.00260632,
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0.1102826,
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0.07373596,
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0.1038363,
-0.1034265,
-0.09270735... |
Inhibition of PKC-dependent extracellular Ca2+ entry contributes to the depression of contractile activity in long-term pressure-overloaded endothelium-denuded rat aortas. | We examined the contractile responsiveness of rat thoracic aortas under pressure overload after long-term suprarenal abdominal aortic coarctation (lt-Srac). Endothelium-dependent angiotensin II (ANG II) type 2 receptor (AT2R)-mediated depression of contractions to ANG II has been reported in short-term (1 week) pressur... | 25,098,618 | [
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Selective naked-eye detection of Hg²⁺ through an efficient turn-on photoinduced electron transfer fluorescent probe and its real applications. | A simple molecular fluorescent probe 5 has been designed and synthesized by appending anthracene and benzhydryl moieties through a piperazine bridge. The probe upon interaction with different metal ions showed high selectivity and sensitivity (2 ppb) for Hg(2+) through fluorescence "turn-on" response in HEPES buffer. T... | 25,098,642 | [
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0.06893431,
0.3828454,
0.3201958,
0.002277312,
... |
Liquid chromatography-electrospray ionization-tandem mass spectrometry quantitation of urinary [pyridine-D4]4-hydroxy-4-(3-pyridyl)butanoic acid, a biomarker of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolic activation in smokers. | 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK, 1) is a potent tobacco-specific lung carcinogen believed to play a key role in the development of lung cancer in smokers. Metabolic activation of NNK to DNA damaging reactive intermediates proceeds via α-hydroxylation pathways. The end products of these pathways are ... | 25,098,652 | [
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0.391283,
0.4057221,
0.05569793,
0.1876553,
0.4000382,
0.00296903,
-0.... |
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