title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Pulp and periodontal healing after replantation of a maxillary immature incisor: a 13-year follow-up. | Traumatic tooth avulsions occur most often in 7 to 9 year-old children. Replantation is considered the treatment of choice and follow-up is required in order to prevent possible complications. A case of replantation of a maxillary immature incisor in a 9.2-year-old male is reported. Tooth 21 was stored in saliva, in th... | 25,101,501 | [
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Multicomponent [5 + 2] cycloaddition reaction for the synthesis of 1,4-diazepines: isolation and reactivity of azomethine ylides. | Air-stable azomethine ylides with an unusual pattern of charge distribution were efficiently prepared via the rhodium-catalyzed reaction between pyridines and 1-sulfonyl-1,2,3-triazoles. This reaction allowed for the first example of the catalytic multicomponent [5 + 2] cycloaddition reactions, thus resulting in the fo... | 25,101,524 | [
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Impact of 160 W Greenlight laser vaporization of the prostate on erectile function: a prospective randomized controlled trial with 1-year follow-up. | Our aim was to evaluate the impact of 160 W Greenlight laser vaporization of the prostate on erectile function by the International Index of Erectile Function (IIEF-5) in 1-year follow-up in patients with lower urinary tract symptoms (LUTS) caused by benign prostatic hyperplasia (BPH). Although high-power Greenlight la... | 25,101,536 | [
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Distal macro- and microembolization during subintimal recanalization of femoropopliteal chronic total occlusions. | To investigate the phenomenon of distal embolization during subintimal angioplasty with or without stenting of femoropopliteal chronic total occlusions (CTOs). This prospective study included 40 consecutive patients (35 men; mean age 65.4±9.3 years) who underwent subintimal angioplasty alone (n=14) or with stenting (n=... | 25,101,573 | [
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First-in-man implantation of a new hybrid carotid stent to prevent periprocedural neurological events during carotid artery stenting. | To report the initial clinical experience with a new hybrid stent to prevent neurological events during carotid artery stenting. A 77-year-old asymptomatic man presented with de novo high-grade stenosis (80%) of the right internal carotid artery (ICA) and occlusion of the contralateral ICA. He was referred for right IC... | 25,101,594 | [
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Surgical management of complex rectourethral fistulas in irradiated and nonirradiated patients. | Rectourethral fistulas are an uncommon, yet devastating occurrence after treatment for prostate cancer or trauma, and their surgical management has historically been nonstandardized. Anecdotally, irradiated rectourethral fistulas portend a worse prognosis. To review outcomes after surgical treatment of rectourethral fi... | 25,101,607 | [
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Expression and immune responses to MAGE antigens predict survival in epithelial ovarian cancer. | The MAGE cancer-testis antigens (CTA) are attractive candidates for immunotherapy. The aim of this study was to determine the frequency of expression, humoral immunity and prognostic significance of MAGE CTA in human epithelial ovarian cancer (EOC). mRNA or protein expression frequencies were determined for MAGE-A1, -A... | 25,101,620 | [
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Unsupervised feature learning improves prediction of human brain activity in response to natural images. | Encoding and decoding in functional magnetic resonance imaging has recently emerged as an area of research to noninvasively characterize the relationship between stimulus features and human brain activity. To overcome the challenge of formalizing what stimulus features should modulate single voxel responses, we introdu... | 25,101,625 | [
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Antibacterial function of the human cathelicidin-18 peptide (LL-37) between theory and practice. | The human cathelicidin-18 is an antimicrobial, immunomodulatory and tissue repair peptide. The LL-37 fragment of this peptide which is in fact the active domain of the cathelicidin-18 is critical for the human antibacterial defense and epithelial integrity. It's activity against resistant pathogens, the potential of ep... | 25,101,632 | [
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Recurrent takotsubo syndrome in a patient with myotonic dystrophy 1. | Stress-induced cardiomyopathy (takotsubo-syndrome, TTS) and its recurrence have not been described in myotonic dystrophy-1. The patient was a 47-year-old female who was suspected to suffer from myotonic dystrophy-1 at 20 years of age, upon the typical clinical presentation and the electrophysiological findings. During ... | 25,101,654 | [
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Effect of feed restriction on performance and postprandial nutrient metabolism in pigs co-infected with Mycoplasma hyopneumoniae and swine influenza virus. | As nutritional status and inflammation are strongly connected, feeding and nutritional strategies could be effective to improve the ability of pigs to cope with disease. The aims of this study were to investigate the impact of a feed restriction on the ability of pigs to resist and be tolerant to a coinfection with Myc... | 25,101,681 | [
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Assessing a financial incentive for reducing length of stay of psychiatric inpatients: implications for financing psychiatric services. | Restricted government budgets are forcing countries to implement more efficient health measures. Unlike in somatic medicine, the process of evaluating payment systems in psychiatry in Switzerland is ongoing. A pilot approach in one psychiatric hospital, here called "new remuneration system (NRS)", was introduced to bet... | 25,101,764 | [
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Differential suppressive effects of testosterone on immune function in fresh water snake, Natrix piscator: an in vitro study. | Reptiles represent the crucial phylogenetic group as they were the ancestors of both birds and mammals hence very important to study. The objectives of the present study were to investigate the potential roles of testosterone in the innate immune responses and splenic lymphocyte proliferation in fresh water snake, Natr... | 25,101,765 | [
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Can economic deprivation protect health? Paradoxical multilevel effects of poverty on Hispanic children's wheezing. | Prior research suggests that economic deprivation has a generally negative influence on residents' health. We employ hierarchical logistic regression modeling to test if economic deprivation presents respiratory health risks or benefits to Hispanic children living in the City of El Paso (Texas, USA) at neighborhood- an... | 25,101,769 | [
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The historical distribution of main malaria foci in Spain as related to water bodies. | The possible connectivity between the spatial distribution of water bodies suitable for vectors of malaria and endemic malaria foci in Southern Europe is still not well known. Spain was one of the last countries in Western Europe to be declared free of malaria by the World Health Organization (WHO) in 1964. This study ... | 25,101,771 | [
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Response regulator heterodimer formation controls a key stage in Streptomyces development. | The orphan, atypical response regulators BldM and WhiI each play critical roles in Streptomyces differentiation. BldM is required for the formation of aerial hyphae, and WhiI is required for the differentiation of these reproductive structures into mature spores. To gain insight into BldM function, we defined the genom... | 25,101,778 | [
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Formation of highly ordered self-assembled monolayers of alkynes on Au(111) substrate. | Self-assembled monolayers (SAMs), prepared by reaction of terminal n-alkynes (HC≡C(CH2)nCH3, n = 5, 7, 9, and 11) with Au(111) at 60 °C were characterized using scanning tunneling microscopy (STM), infrared reflection absorption spectroscopy (IRRAS), X-ray photoelectron spectroscopy (XPS), and contact angles of water. ... | 25,101,784 | [
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Highly conductive anion exchange membrane for high power density fuel-cell performance. | Anion exchange membrane fuel cells (AEMFCs) are regarded as a new generation of fuel cell technology that has the potential to overcome many obstacles of the mainstream proton exchange membrane fuel cells (PEMFCs) in cost, catalyst stability, efficiency, and system size. However, the low ionic conductivity and poor the... | 25,101,785 | [
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Common distal elements orchestrate CIITA isoform-specific expression in multiple cell types. | Major histocompatibility class II (MHC-II) expression is critical for immune responses and is controlled by the MHC-II transactivator CIITA. CIITA is primarily regulated at the transcriptional level and is expressed from three main promoters with myeloid, lymphoid and interferon (IFN)-γ-treated non-hematopoietic cells ... | 25,101,797 | [
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The upside of failure: how regional student groups learn from their mistakes. | Success is the result of planning, hard work, determination, foresight, and a little bit of luck. Unfortunately, nobody has thought to pave the road to success. Although failure can be discouraging and time-consuming, it presents incredible learning opportunities-the biggest difference between those who succeed and tho... | 25,101,799 | [
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High-density genotyping of immune loci in Kawasaki disease and IVIG treatment response in European-American case-parent trio study. | Kawasaki disease (KD) is a diffuse and acute small-vessel vasculitis observed in children, and has genetic and autoimmune components. We genotyped 112 case-parent trios of European decent (confirmed by ancestry informative markers) using the immunoChip array, and performed association analyses with susceptibility to KD... | 25,101,798 | [
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4-Aminopyridyl-based CYP51 inhibitors as anti-Trypanosoma cruzi drug leads with improved pharmacokinetic profile and in vivo potency. | CYP51 is a P450 enzyme involved in the biosynthesis of the sterol components of eukaryotic cell membranes. CYP51 inhibitors have been developed to treat infections caused by fungi, and more recently the protozoan parasite Trypanosoma cruzi, the causative agent of Chagas disease. To specifically optimize drug candidates... | 25,101,801 | [
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Impact of porcine maternal aerobic exercise training during pregnancy on endothelial cell function of offspring at birth. | The purpose of this investigation was to test the hypothesis that maternal exercise training during pregnancy enhances endothelial function in offspring at birth. Six-month-old gilts (n = 8) were artificially inseminated and randomized into exercise-trained (n = 4) and sedentary groups (n = 4). Exercise training consis... | 25,101,806 | [
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Extending the validity of the Personality Assessment Inventory's (PAI) Level of Care Index (LOCI) in multiple psychiatric settings. | The purpose of this study was to extend the validity and clinical application of the Level of Care Index (LOCI) from the Personality Assessment Inventory (PAI) in 2 independent psychiatric samples. In Study 1 (N = 201), the LOCI effectively differentiated level of care (inpatients from outpatients), and was also meanin... | 25,101,817 | [
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The role and advances of immunomodulator therapy for inflammatory bowel disease. | Immune modulating drugs such as thiopurines (azathioprine and 6-mercaptopurine) and methotrexate has been a mainstay for treatment of inflammatory bowel disease (IBD) for decades. However, despite widely used in IBD, questions still remain concerning the most rational treatment regimens of these agents. Results from a ... | 25,101,818 | [
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Ecto-Fc MS identifies ligand-receptor interactions through extracellular domain Fc fusion protein baits and shotgun proteomic analysis. | Ligand-receptor interactions represent essential biological triggers that regulate many diverse and important cellular processes. We have developed a discovery-based proteomic biochemical protocol that couples affinity purification with multidimensional liquid chromatographic tandem mass spectrometry (LCLC-MS/MS) and b... | 25,101,821 | [
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KDM6 demethylase independent loss of histone H3 lysine 27 trimethylation during early embryonic development. | The early mammalian embryo utilizes histone H3 lysine 27 trimethylation (H3K27me3) to maintain essential developmental genes in a repressive chromatin state. As differentiation progresses, H3K27me3 is removed in a distinct fashion to activate lineage specific patterns of developmental gene expression. These rapid chang... | 25,101,834 | [
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Isolated unilateral pulmonary agenesis and other fetal thoracic anomalies. | Although the diagnostic workup and management regimens for many of the common fetal thoracic lesions have been well described, the understanding of pulmonary agenesis is more limited. A better understanding of the published reports of this condition is essential to provide proper care for these complicated pregnancies.... | 25,101,843 | [
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A moving line in the sand: a review of obstetric management surrounding periviability. | Periviable birth poses numerous clinical and ethical challenges for the practicing clinician. We review the data surrounding the administration of corticosteroids for fetal lung maturity, antibiotics in the case of preterm premature rupture of membranes, magnesium sulfate for cerebral palsy prophylaxis, fetal monitorin... | 25,101,845 | [
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Modulatory effects of vasoactive intestinal peptide on intestinal mucosal immunity and microbial community of weaned piglets challenged by an enterotoxigenic Escherichia coli (K88). | Toll-like receptors (TLRs) recognize microbial pathogens and trigger immune response, but their regulation by neuropeptide-vasoactive intestinal peptide (VIP) in weaned piglets infected by enterotoxigenic Escherichia coli (ETEC) K88 remains unexplored. Therefore, the study was conducted to investigate its role using a ... | 25,101,851 | [
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Transcriptional expression analysis of genes involved in regulation of calcium translocation and storage in finger millet (Eleusine coracana L. Gartn.). | Finger millet (Eleusine coracana) variably accumulates calcium in different tissues, due to differential expression of genes involved in uptake, translocation and accumulation of calcium. Ca(2+)/H(+) antiporter (CAX1), two pore channel (TPC1), CaM-stimulated type IIB Ca(2+) ATPase and two CaM dependent protein kinase (... | 25,101,868 | [
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Immune-enhancing activity of polysaccharides from Cyrtomium macrophyllum. | The goal of the present study was to investigate the immune-enhancing activity of polysaccharides from Cyrtomium macrophyllum (CMP). Two experiments were carried out. In immunosuppression experiment, the immune-enhancing effect of CMP in immunosuppressive mice was performed. The results showed that CMP at high and medi... | 25,101,877 | [
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Development of a nanomaterial bio-screening platform for neurological applications. | Nanoparticle platforms are being intensively investigated for neurological applications. Current biological models used to identify clinically relevant materials have major limitations, e.g. technical/ethical issues with live animal experimentation, failure to replicate neural cell diversity, limited control over cellu... | 25,101,878 | [
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Multiparametric imaging of adhesive nanodomains at the surface of Candida albicans by atomic force microscopy. | Candida albicans is an opportunistic pathogen. It adheres to mammalian cells through a variety of adhesins that interact with host ligands. The spatial organization of these adhesins on the cellular interface is however poorly understood, mainly because of the lack of an instrument able to track single molecules on sin... | 25,101,882 | [
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CFTR potentiators: not an open and shut case. | Insights into the positive and negative effects of drugs to treat cystic fibrosis (CF) patients with a common mutation raise questions about how we discover and translate CF therapeutics (Veit et al. and Cholon et al., this issue). | 25,101,884 | [
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Defective PTEN regulation contributes to B cell hyperresponsiveness in systemic lupus erythematosus. | PTEN regulates normal signaling through the B cell receptor (BCR). In systemic lupus erythematosus (SLE), enhanced BCR signaling contributes to increased B cell activity, but the role of PTEN in human SLE has remained unclear. We performed fluorescence-activated cell sorting analysis in B cells from SLE patients and fo... | 25,101,889 | [
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Factor structure and construct validity of the temporal experience of pleasure scales. | Feelings of pleasure felt in the moment of goal attainment (consummatory pleasure) are thought to be dissociable from feelings of desire connected with the motivated approach of goals (anticipatory pleasure). The Temporal Experience of Pleasure Scales (TEPS; Gard, Gard, Kring, & John, 2006) was developed to assess ... | 25,101,907 | [
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Increased frequency of FBN1 truncating and splicing variants in Marfan syndrome patients with aortic events. | Marfan syndrome is a systemic disorder that typically involves FBN1 mutations and cardiovascular manifestations. We investigated FBN1 genotype-phenotype correlations with aortic events (aortic dissection and prophylactic aortic surgery) in patients with Marfan syndrome. Genotype and phenotype information from probands ... | 25,101,912 | [
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The earliest pigeon fanciers. | Feral Pigeons have colonised all corners of the Earth, having developed a close association with humans and their activities. The wild ancestor of the Feral Pigeon, the Rock Dove, is a species of rocky habitats, nesting typically on cliff ledges and at the entrance to large caves. This habit would have brought them int... | 25,101,932 | [
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An antifungal role of hydrogen sulfide on the postharvest pathogens Aspergillus niger and Penicillium italicum. | In this research, the antifungal role of hydrogen sulfide (H2S) on the postharvest pathogens Aspergillus niger and Penicillium italicum growing on fruits and under culture conditions on defined media was investigated. Our results show that H2S, released by sodium hydrosulfide (NaHS) effectively reduced the postharvest ... | 25,101,960 | [
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Ligation of ICAM-1 on human aortic valve interstitial cells induces the osteogenic response: A critical role of the Notch1-NF-κB pathway in BMP-2 expression. | Calcific aortic valve disease (CAVD) is a chronic inflammatory condition and affects a large number of elderly people. Aortic valve interstitial cells (AVICs) occupy an important role in valvular calcification and CAVD progression. While pro-inflammatory mechanisms are capable of inducing the osteogenic responses in AV... | 25,101,972 | [
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The ordered acquisition of Class II and Class I mutations directs formation of human t(8;21) acute myelogenous leukemia stem cell. | The cellular properties of leukemia stem cells (LSCs) are achieved at least through Class I and Class II mutations that generate signals for enhanced proliferation and impaired differentiation, respectively. Here we show that in t(8;21) acute myelogenous leukemia (AML), hematopoietic stem cells (HSCs) transform into LS... | 25,101,977 | [
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Crohn's disease successfully treated with infliximab in a patient receiving hemodialysis: case report and review of the literature. | There is limited information in the use of antitumor necrosis factor α, infliximab, in patients on hemodialysis. In Crohn's disease (CD), only 3 cases are reported.A 76-year-old man on hemodialysis for renal failure caused by immunoglobulin A nephropathy developed diarrhea and abdominal pains. A marked edema was observ... | 25,101,989 | [
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The cohesin subunit Rad21 is required for synaptonemal complex maintenance, but not sister chromatid cohesion, during Drosophila female meiosis. | Replicated sister chromatids are held in close association from the time of their synthesis until their separation during the next mitosis. This association is mediated by the ring-shaped cohesin complex that appears to embrace the sister chromatids. Upon proteolytic cleavage of the α-kleisin cohesin subunit at the met... | 25,101,996 | [
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Random migration and signal integration promote rapid and robust T cell recruitment. | To fight infections, rare T cells must quickly home to appropriate lymph nodes (LNs), and reliably localize the antigen (Ag) within them. The first challenge calls for rapid trafficking between LNs, whereas the second may require extensive search within each LN. Here we combine simulations and experimental data to inve... | 25,102,014 | [
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Effects of nanoparticle size and gestational age on maternal biodistribution and toxicity of gold nanoparticles in pregnant mice. | Gold nanoparticles (GNPs) have considerable applications in biomedicine, such as in bio-sensing, bio-imaging, drug delivery and photothermal therapeutics. However, currently there are limited information regarding the impact of pregnancy on their biodistribution, elimination and toxicity. In this study, we investigated... | 25,102,025 | [
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Whole genome expression analysis in primary bronchial epithelial cells after exposure to sulphur mustard. | Sulphur mustard (SM) is a highly toxic chemical agent and poses a current threat to both civilians and military personnel in the event of a deliberate malicious release. Acute SM toxicity develops over the course of several hours and mainly affects the skin and mucosal surfaces of the eyes and respiratory system. In ca... | 25,102,026 | [
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Quantitative CT analysis of pulmonary ground-glass opacity nodules for the distinction of invasive adenocarcinoma from pre-invasive or minimally invasive adenocarcinoma. | We aimed to analyze the CT findings of ground-glass opacity nodules diagnosed pathologically as adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA), and invasive adenocarcinoma in order to investigate whether quantitative CT parameters enable distinction of invasive adenocarcinoma from pre-invasive or... | 25,102,064 | [
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Performance of Simplexa dengue molecular assay compared to conventional and SYBR green RT-PCR for detection of dengue infection in Indonesia. | Diagnostic tests based on detection of dengue virus (DENV) genome are available with varying sensitivities and specificities. The Simplexa Dengue assay (Focus Diagnostics) is a newly developed real-time RT-PCR method designed to detect and serotype DENV simultaneously. To assess the performance of the Simplexa Dengue a... | 25,102,066 | [
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Relationship between transitional objects and personality disorders in female psychiatric inpatients: a prospective study. | Patients often bring transitional objects (TO) to inpatient units. The authors quantified the frequency of TO possession in an inpatient psychiatric setting and assessed whether TO use is specific to a personality disorder (PD) diagnosis, focusing on borderline PD (BPD). TO possession was assessed using the Transitiona... | 25,102,087 | [
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Novel tetra-peptide insertion in Gag-p6 ALIX-binding motif in HIV-1 subtype C associated with protease inhibitor failure in Indian patients. | A novel tetra-peptide insertion was identified in Gag-p6 ALIX-binding region, which appeared in protease inhibitor failure Indian HIV-1C sequences (odds ratio=17.1, P < 0.001) but was naturally present in half of untreated Ethiopian HIV-1C sequences. The insertion is predicted to restore ALIX-mediated virus release ... | 25,102,091 | [
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Regiospecific Ficini [2 + 2] cycloaddition of ynamides with cyclic isoimidium salts under catalyst-free conditions. | The regiospecific [2 + 2] cycloaddition of cyclic isoimidium salts with ynamides is described. This effort led to the development of the first successful example of a catalyst-free, thermally driven Ficini [2 + 2] cycloaddition process of ynamides with α,β-unsaturated carbonyl compounds, giving the stable cyclobutenami... | 25,102,092 | [
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Over-the-counter migration of steroid use: impact on the eye. | To provide opinions on the potential impact of increasing use of steroids by various formulations, as recent approvals have switched intranasal steroids to over-the-counter (OTC) status. Systemic glucocorticosteroids are the predominant formulations available only by prescription, whereas low-dose dermatological formul... | 25,102,105 | [
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The use of biologicals in cutaneous allergies - present and future. | Up-to-date biologicals in cutaneous allergies play - unfortunately - only a minor role. However, this situation might change. Recently, omalizumab was licensed for chronic urticaria; this article reviews recent advances in the use of biologicals in cutaneous allergies. Interestingly, the mechanism of omalizumab appears... | 25,102,106 | [
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Update on the challenges facing the adult with congenital heart disease community: for both the patient and provider. | The success in the management of congenital heart disease has resulted in a growing population now expected to reach adulthood. The declining mortality during childhood results in adults with decades of cardiovascular disease burden. The purpose of this review is to provide an update on some of the common issues encoun... | 25,102,108 | [
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Molecular expression and functional activity of vitamin C specific transport system (SVCT2) in human breast cancer cells. | The main goal of this study is to investigate the expression of sodium dependent vitamin C transport system (SVCT2). Moreover, this investigation has been carried out to define uptake mechanism and intracellular regulation of ascorbic acid (AA) in human breast cancer cells (MDA-MB231, T47D and ZR-75-1). Uptake of [(14)... | 25,102,111 | [
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von Hippel-Lindau disease and pregnancy: what an obstetrician should know. | von Hippel-Lindau disease is an autosomal dominant genetic disorder that presents with a variable constellation of symptoms and signs due to formation of hemangioblastomas and cysts. We address the management of pregnancies associated with this disorder from an obstetric perspective. A 26-year-old known to have type 2A... | 25,102,122 | [
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Possible antioxidant mechanism of melanoidins extract from Shanxi aged vinegar in mitophagy-dependent and mitophagy-independent pathways. | Melanoidins are widely reported to have antioxidant activity; however, their mechanism has not been frequently studied. In this study, we found that melanoidins from Shanxi aged vinegar induced mitopahgy, the specific autophagic elimination of mitochondria, as assessed by up-regulation of the autophagy markers LC3-II a... | 25,102,123 | [
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Memory beyond expression. | The idea that memories are not invariable after the consolidation process has led to new perspectives about several mnemonic processes. In this framework, we review our studies on the modulation of memory expression during reconsolidation. We propose that during both memory consolidation and reconsolidation, neuromodul... | 25,102,126 | [
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Stepwise preparation of all-cis 1,3,4-trifluoro-2-phenylcyclohexane, avoiding a phenonium intermediate. | The original synthesis of all-cis 1,2,4,5,-tetrafluoro-2-phenylcyclohexane resulted in a trifluorocyclohexene as a significant co-product of the final fluorination step. This product was notable in that an elimination reaction was accompanied by C-F bond formation that had occurred with a retention of configuration. In... | 25,102,142 | [
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Pt@Au nanorods uniformly decorated on pyridyne cycloaddition graphene as a highly effective electrocatalyst for oxygen reduction. | Preparing metal-supported graphene nanocomposites is both interesting and challenging because of their well-defined morphologies and have potential application for oxygen reduction reaction (ORR). Here, we present an easy approach to synthesizing a novel hybrid material composed of Pt@Au nanorods (NRs) uniformly disper... | 25,102,156 | [
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The association of early childhood cognitive development and behavioural difficulties with pre-adolescent problematic eating attitudes. | Few studies have prospectively investigated associations of child cognitive ability and behavioural difficulties with later eating attitudes. We investigated associations of intelligence quotient (IQ), academic performance and behavioural difficulties at 6.5 years with eating attitudes five years later. We conducted an... | 25,102,171 | [
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Cystic echinococcosis in the Province of Álava, North Spain: the monetary burden of a disease no longer under surveillance. | Cystic echinococcosis (CE) is endemic in Spain but has been considered non-endemic in the province of Álava, Northern Spain, since 1997. However, Álava is surrounded by autonomous regions with some of the highest CE prevalence proportions in the nation, casting doubts about the current classification. The purpose of th... | 25,102,173 | [
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Salivary gland proteome analysis reveals modulation of anopheline unique proteins in insensitive acetylcholinesterase resistant Anopheles gambiae mosquitoes. | Insensitive acetylcholinesterase resistance due to a mutation in the acetylcholinesterase (ace) encoding ace-1 gene confers cross-resistance to organophosphate and carbamate insecticides in Anopheles gambiae populations from Central and West Africa. This mutation is associated with a strong genetic cost revealed throug... | 25,102,176 | [
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Anorexia, anxiety, and the object. | Anorexia among young girls is an increasingly common phenomenon, one that raises questions of psychopathology. Anorexia at the time of puberty is not so much a rejection of femininity as an attempt to limit the "feminine jouissance," in Lacan's terminology, demarcated neither by border nor by semblance. Currently, wher... | 25,102,186 | [
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Postoperative restoration of foveal inner retinal configuration in patients with epiretinal membrane and abnormally thick inner retina. | To investigate foveal inner retinal layer (IRL) restoration and its relationship with functional visual outcomes after membrane peeling in eyes with idiopathic epiretinal membrane (ERM) with foveal central thick IRL. Consecutive eyes (n = 57) with a thick foveal IRL that underwent 25-gauge vitrectomy for ERM treatment ... | 25,102,192 | [
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Combined hamartoma of the retina and retinal pigment epithelium: findings on enhanced depth imaging optical coherence tomography in eight eyes. | To assess combined hamartoma of the retina and retinal pigment epithelium with enhanced depth imaging optical coherence tomography. Retrospective, observational cases series in eight eyes of eight patients, with comparison between affected and unaffected eyes regarding enhanced depth imaging optical coherence tomograph... | 25,102,194 | [
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Liver bioengineering: from the stage of liver decellularized matrix to the multiple cellular actors and bioreactor special effects. | Liver bioengineering has been a field of intense research and popular excitement in the past decades. It experiences great interest since the introduction of whole liver acellular scaffolds generated by perfusion decellularization (1-3). Nevertheless, the different strategies developed so far have failed to generate he... | 25,102,189 | [
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Sampling of intracellular metabolites for stationary and non-stationary (13)C metabolic flux analysis in Escherichia coli. | The analysis of metabolic intermediates is a rich source of isotopic information for (13)C metabolic flux analysis ((13)C-MFA) and extends the range of its applications. The sampling of labeled metabolic intermediates is particularly important to obtain reliable isotopic information. The assessment of the different sam... | 25,102,204 | [
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Comparative gene array analysis of progenitor cells from human paired deep neck and subcutaneous adipose tissue. | Brown and white adipocytes have been shown to derive from different progenitors. In this study we sought to clarify the molecular differences between human brown and white adipocyte progenitors cells. To this end, we performed comparative gene array analysis on progenitor cells isolated from paired biopsies of deep and... | 25,102,227 | [
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D-α-tocopherol polyethylene glycol succinate-based redox-sensitive paclitaxel prodrug for overcoming multidrug resistance in cancer cells. | To overcome the multidrug resistance (MDR) of P-glycoprotein (P-gp) substrate anticancer drugs, such as paclitaxel (PTX), a novel dual-functional prodrug, D-α-tocopherol polyethylene glycol succinate (TPGS) based PTX prodrug (TPGS-S-S-PTX), was synthesized here to fulfill the synergistic effect of P-gp inhibiting and i... | 25,102,234 | [
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Fat mass and obesity-associated (FTO) gene polymorphisms are associated with physical activity, food intake, eating behaviors, psychological health, and modeled change in body mass index in overweight/obese Caucasian adults. | The fat mass and obesity-associated (FTO) gene is currently recognized as the most robust predictor of polygenic obesity. We investigated associations between the FTO rs1421085 and rs17817449 polymorphisms and the FTO rs1421085-rs17817449 haplotype and dietary intake, eating behavior, physical activity, and psychologic... | 25,102,252 | [
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Antibiotic susceptibility of periodontal Streptococcus constellatus and Streptococcus intermedius clinical isolates. | Streptococcus constellatus and Streptococcus intermedius in subgingival dental plaque biofilms may contribute to forms of periodontitis that resist treatment with conventional mechanical root debridement/surgical procedures and may additionally participate in some extraoral infections. Because systemic antibiotics are ... | 25,102,269 | [
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First-in-man demonstration of a fully implanted myoelectric sensors system to control an advanced electromechanical prosthetic hand. | Advanced motorized prosthetic devices are currently controlled by EMG signals generated by residual muscles and recorded by surface electrodes on the skin. These surface recordings are often inconsistent and unreliable, leading to high prosthetic abandonment rates for individuals with upper limb amputation. Surface ele... | 25,102,286 | [
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Branch migration prevents DNA loss during double-strand break repair. | The repair of DNA double-strand breaks must be accurate to avoid genomic rearrangements that can lead to cell death and disease. This can be accomplished by promoting homologous recombination between correctly aligned sister chromosomes. Here, using a unique system for generating a site-specific DNA double-strand break... | 25,102,287 | [
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Capsid protein VP4 of human rhinovirus induces membrane permeability by the formation of a size-selective multimeric pore. | Non-enveloped viruses must deliver their viral genome across a cell membrane without the advantage of membrane fusion. The mechanisms used to achieve this remain poorly understood. Human rhinovirus, a frequent cause of the common cold, is a non-enveloped virus of the picornavirus family, which includes other significan... | 25,102,288 | [
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Transplantation between monozygotic twins: how identical are they? | Advances in developmental biology have shown that monozygous twins may not be as phenotypically identical as once believed, and the mechanisms responsible for such differences are now becoming clearer. Whether such phenotypic differences are capable of triggering graft rejection of an organ transplanted between identic... | 25,102,303 | [
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Validating the allogeneic stem cell transplantation disease risk index: sample size, follow-up, and local data are important. | Reporting allogeneic hematopoietic stem cell transplantation (alloHSCT) outcomes by disease and disease stage can limit statistical power. Recently, the disease risk index (DRI) was developed and validated to stratify clusters of patients with various combinations of disease and stage for overall survival (OS), progres... | 25,102,305 | [
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Kinematic analysis of basic rhythmic movements of hip-hop dance: motion characteristics common to expert dancers. | In hip-hop dance contests, a procedure for evaluating performances has not been clearly defined, and objective criteria for evaluation are necessary. It is assumed that most hip-hop dance techniques have common motion characteristics by which judges determine the dancer's skill level. This study aimed to extract motion... | 25,102,329 | [
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Effect of some experimental interviewing techniques on reporting in the health interview survey. | This experimental field study was carried out to test certain questionnaire designs and inter-viewing techniques which might improve the re-porting of health events in a modified Health Interview Survey household interview. This study is one in a series conducted for the National Center for Health Statistics (NCHS); th... | 25,102,349 | [
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Expression and localization of rhoptry neck protein 5 in merozoites and sporozoites of Plasmodium yoelii. | Host cell invasion by Apicomplexan parasites marks a crucial step in disease establishment and pathogenesis. The moving junction (MJ) is a conserved and essential feature among parasites of this phylum during host cell invasion, thus proteins that associate at this MJ are potential targets of drug and vaccine developme... | 25,102,354 | [
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Cell therapies for tendons: old cell choice for modern innovation. | Although tissue engineering and cell therapies are becoming realistic approaches for medical therapeutics, it is likely that musculoskeletal applications will be among the first to benefit on a large scale. Cell sources for tissue engineering and cell therapies for tendon pathologies are reviewed with an emphasis on sm... | 25,102,358 | [
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0.1949204,
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-... |
Comorbidity and functional mobility in persons with Parkinson disease. | To report the frequency, severity, and types of comorbidities in people with Parkinson disease (PD) using a validated self-report comorbidity screening tool, and to determine the relationship between comorbidity and functional mobility. A secondary analysis and cross-sectional observational study design. University hos... | 25,102,383 | [
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Seeing liquids from visual motion. | Most research on human visual recognition focuses on solid objects, whose identity is defined primarily by shape. In daily life, however, we often encounter materials that have no specific form, including liquids whose shape changes dynamically over time. Here we show that human observers can recognize liquids and thei... | 25,102,388 | [
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Dopamine D3 receptor Ser9Gly and catechol-o-methyltransferase Val158Met polymorphisms and acute pain in sickle cell disease. | Pain in sickle cell disease (SCD) is characterized by episodes of acute pain, primarily responsible for acute health care utilization, and persistent chronic pain. Pain severity and frequency vary significantly among patients with SCD. In this study, we investigated the possible contribution of monoamine gene polymorph... | 25,102,390 | [
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Reverse intersystem crossing in rhodamines by near-infrared laser excitation. | The population of the long-lived first excited triplet state (T1) of a fluorescence dye represents a major limitation in single-molecule spectroscopy. Reverse intersystem crossing (ReISC) is one of the processes that may prevent considerable loss of luminescence. In the present quantum chemical study we have analyzed r... | 25,102,421 | [
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Morningness-eveningness questionnaire score and metabolic parameters in patients with type 2 diabetes mellitus. | "Morningness" and "Eveningness" represent lifestyle patterns including sleep-wake patterns. Although previous studies described a relationship between the morningness-eveningness trait and glycemic control in patients with type 2 diabetes mellitus (T2DM), the mechanism underlying this association remains unknown. The s... | 25,102,425 | [
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Bovine papillomavirus isolation by ultracentrifugation. | The bovine papillomavirus (BPV) is the etiological agent of bovine papillomatosis, which causes significant economic losses to livestock, characterized by the presence of papillomas that regress spontaneously or persist and progress to malignancy. Currently, there are 13 types of BPVs described in the literature as wel... | 25,102,429 | [
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New developments in the treatment of pediatric allergic rhinitis and conjunctivitis. | The primary care physician is the first line of treatment for allergic rhinitis, which affects approximately one-fourth of children in the United States. There is an increasing trend toward self-management by patients or parents due to high-deductible insurance plans and the over-the-counter availability of allergy med... | 25,102,489 | [
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Adolescent hallux valgus revisited. | Treatment of adolescent hallux valgus with first metatarsal double osteotomy is well described in the literature. Unfortunately, first metatarsal phalangeal joint stiffness and deformity recurrence have been reported at relatively high rates. The authors revisit a technique aimed at preventing these complications. | 25,102,495 | [
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Clinical outcomes of single-row arthroscopic revision rotator cuff repair. | This article reports the authors' experience with single-row arthroscopic revision rotator cuff repairs and analyzes the variables associated with a poorer long-term outcome. A retrospective review was performed of patients who had undergone an all-arthroscopic, single-row revision rotator cuff repair for pain with a d... | 25,102,504 | [
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Performance and return-to-sport after ACL reconstruction in NFL quarterbacks. | Anterior cruciate ligament (ACL) rupture is a significant injury in National Football League (NFL) quarterbacks. The purpose of this study was to determine (1) return-to-sport (RTS) rate in NFL quarterbacks following ACL reconstruction, (2) performance upon RTS, and (3) the difference in RTS and performance between pla... | 25,102,509 | [
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Review of mobile health technology for military mental health. | Mental health problems pose challenges for military veterans, returning service members, and military family members including spouses and children. Challenges to meeting mental health needs include improving access to care and improving quality of care. Mobile Health, or "mHealth," can help meet these needs in the gar... | 25,102,529 | [
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En route care patient safety: thoughts from the field. | The purpose of this study was to describe the patient safety culture of en route care in the United States Air Force aeromedical evacuation system. Almost 100,000 patients have been transported since 2001. Safety concerns in this unique environment are complex because of the extraordinary demands of multitasking, time ... | 25,102,543 | [
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0.258875... |
Pathophysiology of blast-induced ocular trauma with apoptosis in the retina and optic nerve. | Blast-induced ocular trauma is a frequent cause of morbidity for survivors of improvised explosive devices. Blast overpressure (BOP) of 120 ± 7 KPa has been shown to cause damage to lungs, brain, and gut in a rat model; however, the effects of BOP on ocular tissues have not been characterized. To elucidate the pathophy... | 25,102,547 | [
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0.1300027,
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0.19653... |
MicroRNA maintenance of cone outer segments. | The function of cone photoreceptors depends upon the formation and maintenance of outer segments, which are lost in degenerative diseases. reveal a critical role for microRNAs, specifically miR-182 and miR-183, in the maintenance of these specialized structures. | 25,102,555 | [
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Ready, set, grow. | As baby boomers age, they'll need more health care services. That poses a challenge to the new models of care now being developed. | 25,102,623 | [
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[Pollen morphology of species of genus Senna (Fabales: Fabaceae) in Southeast Ibera, Corrientes, Argentina]. | The system of Ibera lake and marshes in the Province of Corrientes, covers an area of approximately 12 000km2, and is considered one of the most important wetlands in Latin America. Given the wide diversity of tropical communities in this area, it is important to generate new information about the different species of ... | 25,102,657 | [
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Spatial references and audio-tactile interaction in cross-modal dynamic capture. | In audiotactile dynamic capture, judgment of the direction of an apparent motion stream (such as auditory motion) was impeded (hence 'captured') by the presentation of a concurrent, but directionally opposite apparent motion stream (such as tactile motion) from a distractor modality, leading to a cross-modal dynamic ca... | 25,102,666 | [
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Analgesic effect of different moxibustion durations in rheumatoid arthritis rats. | To observe the influence of different moxibustion durations on hypothalamic pro-opiomelanocortin (POMC) and prodynorphin (PDYN) mRNA expressions and plasma beta-endorphin (beta-EP) content in rheumatoid arthritis (RA) rats, to understand the mechanism of moxibustion analgesia and its dose-effect relationship. Twelve ma... | 25,102,697 | [
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... |
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