title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
|---|---|---|---|
Lack of association between miR-27a, miR-146a, miR-196a-2, miR-492 and miR-608 gene polymorphisms and colorectal cancer. | Colorectal cancer (CRC) is one of the most common cancers worldwide with high mortality rates. MicroRNAs (miRNAs) have an established role in the development of different cancers. Single nucleotide polymorphisms (SNPs) in miRNA related genes were linked with various gastrointestinal malignancies. However, the data on a... | 25,103,961 | [
-0.1195168,
-0.2043079,
0.03232911,
-0.2549644,
-0.06968767,
-0.005841865,
-0.2606009,
0.01017007,
-0.04200849,
-0.04902256,
0.2029376,
0.4252779,
0.05341601,
-0.2757117,
-0.1719179,
-0.5196846,
-0.1277717,
0.03629993,
0.1400288,
0.1821962,
0.1191817,
0.4693217,
0.0176719... |
Systemic stiffening of mouse tail tendon is related to dietary advanced glycation end products but not high-fat diet or cholesterol. | Tendon pathology is related to metabolic disease and mechanical overloading, but the effect of metabolic disease on tendon mechanics is unknown. This study investigated the effect of diet and apolipoprotein E deficiency (ApoE(-/-)) on mechanical properties and advanced glycation end product (AGE) cross-linking of non-w... | 25,103,969 | [
-0.08216076,
0.1907424,
-0.4036627,
-0.05788797,
0.0317159,
-0.1809233,
0.2547496,
0.1274351,
0.04385726,
0.2699566,
-0.06179217,
0.2137241,
0.2215134,
0.2105431,
-0.5799321,
-0.25666,
-0.03461847,
0.1764513,
-0.5684521,
0.3631057,
0.03045549,
-0.1266393,
0.02794428,
-0... |
[Fall prevention counselling for patients with hearing and balance disorders]. | Otolaryngologists caring for patients with hearing and balance disorders are also responsible for advising patients about their increased risk of falling and informing them of fall prevention measures. This review will give a brief overview of appropriate programs. This systematic review is based on a selective literat... | 25,103,988 | [
-0.4525067,
0.3088834,
0.2976173,
-0.1565463,
0.07820396,
-0.3409496,
-0.0501536,
-0.2712447,
0.1053803,
0.1760419,
0.08426125,
-0.180901,
0.2161002,
-0.07720934,
-0.3019189,
0.1140769,
-0.3947452,
0.3598999,
-0.3557344,
-0.07976329,
-0.05224093,
0.3199569,
0.005241071,
... |
Biogenetically inspired total syntheses of Lycopodium alkaloids, (+)-flabellidine and (-)-lycodine. | The first asymmetric total synthesis of (+)-flabellidine (2) and the shortest total synthesis of (-)-lycodine (3) were accomplished by a strategy featuring the one-pot construction of a tetracyclic lycodine skeleton from a linear precursor, which was inspired by the biosynthetic consideration of Lycopodium alkaloids. | 25,103,992 | [
-0.10576,
0.1654154,
-0.3106038,
0.05787185,
0.2451394,
-0.0203666,
-0.2447108,
-0.05289167,
0.1143319,
-0.1136583,
-0.1561173,
0.1823879,
0.1543785,
0.3133113,
-0.05444745,
0.05075584,
-0.4959098,
0.1395682,
0.008348831,
-0.2324946,
0.4508607,
0.3410229,
-0.1975957,
-0... |
Evaluation of the hydrolysis specificity of protease from marine Exiguobacterium sp. SWJS2 via free amino acid analysis. | This study evaluates the hydrolysis specificity of newly developed protease from Exiguobacterium sp. SWJS2 (EP) based on the released free amino acid (FAA) during enzymolysis and through comparing with commercially available papain and Alcalase 2.4L. Results showed that EP had great potential in producing hydrolysates ... | 25,104,000 | [
-0.03071161,
-0.2656859,
-0.07020031,
-0.07233414,
-0.213385,
-0.2632397,
0.08393407,
0.6279607,
0.3303497,
-0.05561343,
0.1436547,
0.4496886,
0.0491255,
-0.09968192,
0.01124606,
-0.1301413,
-0.6334464,
0.4956243,
0.1097531,
-0.1088182,
0.4714245,
0.07052439,
-0.3158874,
... |
Chinese talismans as a source of lead exposure. | We describe a case of lead exposure after prolonged intake of ashes from burnt Chinese talismans. A 41-year-old woman presented with elevated blood lead level during screening for treatable causes of progressive weakness in her four limbs, clinically compatible with motor neuron disease. The source of lead exposure was... | 25,104,009 | [
-0.2150988,
0.1158061,
-0.2038994,
0.1168573,
-0.1557115,
-0.01786328,
-0.3600024,
0.08343434,
0.1034671,
0.2002484,
0.06675206,
0.4132529,
0.05394882,
-0.08656541,
0.07560345,
0.003562173,
-0.353947,
0.2120911,
-0.03535651,
0.06470452,
0.1434039,
0.603459,
0.01069801,
... |
Structural and kinetic insights into binding and incorporation of L-nucleotide analogs by a Y-family DNA polymerase. | Considering that all natural nucleotides (D-dNTPs) and the building blocks (D-dNMPs) of DNA chains possess D-stereochemistry, DNA polymerases and reverse transcriptases (RTs) likely possess strongD-stereoselectivity by preferably binding and incorporating D-dNTPs over unnatural L-dNTPs during DNA synthesis. Surprisingl... | 25,104,018 | [
0.02291697,
0.389119,
-0.18162,
0.274233,
0.1208242,
-0.2956522,
-0.2602664,
0.1064911,
0.2445905,
0.002810345,
0.1849947,
0.1943968,
-0.1211304,
0.428204,
-0.7487822,
0.0802582,
-0.4255059,
0.02753923,
-0.04989113,
0.2501531,
0.3264529,
0.1541978,
-0.5019172,
-0.033757... |
Arginine methylation of hnRNPK negatively modulates apoptosis upon DNA damage through local regulation of phosphorylation. | Heterogeneous nuclear ribonucleoprotein K (hnRNPK) is an RNA/DNA-binding protein involved in chromatin remodeling, RNA processing and the DNA damage response. In addition, increased hnRNPK expression has been associated with tumor development and progression. A variety of post-translational modifications of hnRNPK have... | 25,104,022 | [
-0.09795996,
0.2086832,
0.2324554,
-0.2043374,
-0.1115424,
-0.02614387,
0.1146625,
0.4924628,
0.5045864,
0.452856,
0.3137473,
0.04903328,
-0.3394839,
0.05083375,
0.3963119,
0.2677066,
-0.4850923,
-0.0201451,
0.0555825,
-0.3210033,
0.1086972,
0.2272627,
-0.3146577,
0.207... |
Double substituted variant of Bacillus amyloliquefaciens esterase with enhanced enantioselectivity and high activity towards 1-(3',4'-methylenedioxyphenyl)ethyl acetate. | Bacillus amyloliquefaciens esterase (BAE) was applied to produce (R)-1-(3',4'-methylenedioxyphenyl)ethanol, a chiral drug intermediate. In this study, we improved the enantioselectivity of BAE by protein engineering instead of process engineering as used in our previous work. Saturation mutagenesis was carried out on e... | 25,104,035 | [
-0.1796306,
0.0501737,
-0.2598507,
0.01551357,
-0.07474995,
-0.07834888,
-0.05521158,
0.04349829,
0.04698654,
0.03212498,
-0.0533646,
0.0794305,
-0.2441563,
0.325969,
-0.4339938,
0.01150542,
-0.4554839,
0.1134932,
-0.1337793,
0.2419253,
0.1892509,
0.2667859,
0.01572421,
... |
The Arabidopsis polyadenylation factor subunit CPSF30 as conceptual link between mRNA polyadenylation and cellular signaling. | Alternative polyadenylation plays important roles in growth processes in plants. Although the scope and significance of the phenomenon have been described to considerable extent, the mechanisms that govern differential poly(A) site selection remain active areas of investigation. Of particular interest are the means by ... | 25,104,048 | [
0.04117877,
-0.1669821,
-0.1116807,
-0.005828973,
0.2266244,
0.1164204,
0.04331939,
0.03199357,
0.0575262,
0.1274825,
0.1037678,
0.1615298,
-0.0420353,
-0.2623249,
-0.1048703,
-0.2509651,
-0.488672,
-0.007339776,
-0.07670591,
-0.09791699,
0.3174123,
0.4395456,
-0.1595102,... |
ABA-dependent and ABA-independent signaling in response to osmotic stress in plants. | Plants have adaptive robustness to osmotic stresses such as drought and high salinity. Numerous genes functioning in stress response and tolerance are induced under osmotic conditions in diverse plants. Various signaling proteins, such as transcription factors, protein kinases and phosphatases, play signal transduction... | 25,104,049 | [
0.2255841,
-0.2013873,
0.2562522,
-0.02380498,
-0.08841467,
-0.09244598,
0.005121931,
-0.007979307,
0.02528258,
-0.2846293,
0.1971298,
0.002424324,
-0.3123316,
-0.0328416,
-0.03736186,
-0.5408809,
-0.4063889,
0.1722941,
-0.1215295,
-0.2968162,
0.3311549,
0.3040153,
-0.422... |
Disciplined doctors: does the sex of a doctor matter? A cross-sectional study examining the association between a doctor's sex and receiving sanctions against their medical registration. | To examine the association between doctors' sex and receiving sanctions on their medical registration, while controlling for other potentially confounding variables. Cross-sectional study. The General Medical Council (GMC)'s List of Registered Medical Practitioners (LRMP) database of doctors practising in the UK. All d... | 25,104,057 | [
-0.01416788,
0.05840186,
0.2683664,
-0.1369674,
-0.01734391,
-0.3551424,
-0.05549052,
-0.1421955,
-0.008209287,
0.06581534,
-0.2146481,
0.05466843,
0.2537613,
-0.0105521,
-0.2406536,
-0.5879645,
-0.06310593,
-0.2549817,
-0.04511258,
-0.001214419,
-0.2211784,
-0.04416342,
... |
Loss of adaptive variation during evolutionary responses to climate change. | The changes in species' geographical distribution demanded by climate change are often critically limited by the availability of key interacting species. In such cases, species' persistence will depend on the rapid evolution of biotic interactions. Understanding evolutionary limits to such adaptation is therefore cruci... | 25,104,062 | [
0.2014544,
-0.1011683,
-0.09530509,
0.08576822,
0.006710331,
-0.01899707,
-0.1279972,
-0.005337113,
0.06535356,
0.03416296,
0.134524,
0.01217121,
-0.09100666,
-0.1826067,
-0.217206,
-0.2659284,
-0.2440174,
0.1211936,
-0.01867024,
0.09970347,
0.05047542,
0.3828216,
-0.3693... |
New strategies in advanced cervical cancer: from angiogenesis blockade to immunotherapy. | Cervical cancer remains unique among solid tumor malignancies. Persistent infection with oncogenic subtypes of the human papillomavirus (HPV) results in carcinogenesis, predominantly occurring at the cervical transformation zone where endocervical columnar cells undergo metaplasia to a stratified squamous epithelium. T... | 25,104,084 | [
-0.1477768,
0.2225588,
0.07537977,
-0.133343,
-0.1468942,
-0.4111926,
-0.01560633,
0.2641877,
0.3756193,
0.2094319,
0.09182,
0.2505502,
-0.269425,
-0.3343575,
-0.1367424,
-0.1800139,
-0.169535,
-0.1606494,
0.2911263,
-0.1709214,
0.1127972,
0.3864982,
-0.2554636,
0.08937... |
Encapsulation of albumin in self-assembled layer-by-layer microcapsules: comparison of co-precipitation and adsorption techniques. | The objective of this study is to prepare and characterize polymeric self-assembled layer-by-layer microcapsules (LbL-MC) to deliver a model protein, bovine serum albumin (BSA). The aim is to compare the BSA encapsulation in LbL-MC using co-precipitation and adsorption methods. In co-precipitation method, BSA was co-pr... | 25,104,114 | [
-0.1169305,
0.04942952,
-0.1286923,
-0.01741889,
-0.07122551,
-0.06008134,
-0.2172953,
0.0801504,
0.1398354,
0.1512822,
-0.07374226,
0.2104159,
0.03079159,
-0.1391897,
-0.4394258,
0.05245866,
-0.2841496,
-0.1151576,
0.1519802,
0.2665582,
0.2953572,
0.1219673,
-0.09823176,... |
A perpetual source of DNA or something really different: ethical issues in the creation of cell lines for African genomics research. | The rise of genomic studies in Africa - not least due to projects funded under H3Africa - is associated with the development of a small number of biorepositories across Africa. For the ultimate success of these biorepositories, the creation of cell lines including those from selected H3Africa samples would be beneficia... | 25,104,115 | [
-0.1293851,
-0.002420455,
0.04733026,
-0.2244385,
0.02183379,
0.01166307,
-0.233105,
0.3239928,
0.1238044,
0.04525133,
-0.09675002,
-0.005237786,
0.07497246,
0.05530148,
-0.568175,
-0.1343223,
-0.04474591,
0.06719662,
-0.5328046,
0.2473603,
0.1510201,
0.3344632,
-0.319803... |
Differentiation of vanA-positive Enterococcus faecium from vanA-negative E. faecium by matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry. | Vancomycin-resistant enterococci are important nosocomial pathogens that require rapid and accurate detection for infection control. Matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry (MALDI-TOF/MS) has begun to be used in many clinical laboratories because it is a rapid, simple and inexpensiv... | 25,104,134 | [
-0.03885739,
-0.2402936,
0.03863232,
-0.2459639,
-0.018564,
-0.3182455,
0.1510513,
0.007488342,
0.1095534,
-0.09299143,
0.2390748,
0.5603316,
0.2458375,
-0.1591483,
-0.05365139,
-0.5169644,
-0.3814122,
0.3168961,
0.251166,
0.04860615,
-0.186021,
0.001148599,
-0.2883261,
... |
Economic development and coastal ecosystem change in China. | Despite their value, coastal ecosystems are globally threatened by anthropogenic impacts, yet how these impacts are driven by economic development is not well understood. We compiled a multifaceted dataset to quantify coastal trends and examine the role of economic growth in China's coastal degradation since the 1950s.... | 25,104,138 | [
0.08088022,
-0.0005567908,
0.2422571,
0.2042458,
-0.07281432,
-0.00863116,
-0.2821815,
0.3884206,
0.196969,
-0.07311242,
-0.07691301,
-0.2272343,
-0.2355023,
0.06623333,
-0.04286941,
0.09836534,
-0.2154693,
0.3078558,
0.1328799,
0.1556429,
-0.06140733,
0.4678356,
-0.22681... |
Overexpression of GOLPH3 is associated with poor prognosis and clinical progression in pancreatic ductal adenocarcinoma. | Golgi phosphoprotein 3 (GOLPH3) has been identified as an oncoprotein in various human cancers; however, its role in pancreatic ductal adenocarcinoma (PDAC) is unknown. We examined GOLPH3 expression levels and relationship with survival in patients with PDAC to establish the significance of GOLPH3 in the development an... | 25,104,140 | [
0.1649239,
-0.0173307,
-0.3372111,
0.165211,
-0.08022287,
-0.196663,
0.07635974,
0.2586592,
0.0513979,
0.1626363,
0.05845515,
0.006328867,
-0.01638606,
-0.3189824,
-0.2587793,
-0.3041643,
-0.2677504,
0.3010321,
0.378921,
0.002316171,
-0.1841505,
0.1767007,
-0.1017428,
0... |
Risk factors for noma disease: a 6-year, prospective, matched case-control study in Niger. | Noma is a poorly studied disease that leads to severe facial tissue destruction in children in developing countries, but the cause remains unknown. We aimed to identify the epidemiological and microbiological risk factors associated with noma disease. We did a prospective, matched, case-control study in Niger between A... | 25,104,163 | [
-0.06422279,
-0.1224307,
0.1656259,
-0.07485833,
-0.002533301,
-0.4560401,
-0.1729124,
-0.1798831,
-0.1853487,
-0.3492541,
-0.2010735,
0.001050642,
0.1668206,
-0.17151,
-0.3520323,
-0.1146719,
-0.3285864,
-0.06513645,
0.05850329,
-0.01357133,
0.181005,
0.2153463,
-0.30205... |
Can positron emission tomography-computed tomography predict response in locally advanced rectal cancer patients treated with induction folinic acid and 5-florouracil? | The aim of this study was to determine the pathological complete response rates in a group of locally advanced rectal cancer patients who underwent chemoradiotherapy (CRT) after treatment with induction folinic acid and 5-florouracil (FOLFOX) chemotherapy and the relationship between the complete response and positron ... | 25,104,195 | [
0.1099265,
-0.1659469,
-0.2848722,
-0.06633249,
0.2414511,
-0.4157323,
0.1601316,
-0.03937946,
-0.1238718,
0.1025817,
-0.06210431,
0.03072467,
0.0108088,
0.1871571,
-0.2571786,
-0.499653,
-0.03300202,
0.4793265,
0.1444098,
0.2348411,
0.1725608,
0.3746178,
-0.3479153,
0.... |
Hemi- and holo-directed lead(II) complexes in a soft ligand environment. | To investigate the geometry and stereochemical activity of the lone pair at the lead atom, lead(ii) complexes () with one tripodal (L(1)), one dipodal (L(2)) boron-centred soft ligand and eight other small soft heterocyclic ligands, 2-mercaptobenzimidazole (L(3)), 2-mercapto-5-methylbenzimidazole (L(4)), 3-mercapto-1,2... | 25,104,214 | [
-0.1375085,
0.1486398,
-0.01793743,
0.1867937,
-0.03582068,
-0.07222711,
-0.3905787,
0.02752903,
-0.03188159,
-0.05803278,
-0.01416945,
0.3128516,
0.07195252,
0.1084143,
-0.4833464,
-0.1717564,
-0.5751672,
0.2082369,
0.09315505,
0.2764191,
0.4351211,
0.4290683,
-0.0505255... |
A randomised controlled trial of a computerised intervention for children with social communication difficulties to support peer collaboration. | An intervention aiming to support children with social communication difficulties was tested using a randomised controlled design. Children aged 5-6 years old (n=32) were tested and selected for participation on the basis of their scores on the Test of Pragmatic Skills (TPS) and were then randomly assigned to the inter... | 25,104,223 | [
-0.07320201,
0.4536046,
0.1306346,
-0.05524386,
0.06102468,
-0.08823229,
-0.3900787,
-0.01496276,
-0.001461695,
-0.3756038,
0.1519382,
0.1862635,
-0.3756777,
-0.2001594,
-0.4086277,
0.0392217,
0.3755483,
0.2173664,
-0.0643642,
-0.06038738,
0.04304965,
0.1559878,
0.0739274... |
Identification of children with mathematics learning disabilities (MLDs) using latent class growth analysis. | The traditional way of identifying children with mathematics learning disabilities (MLDs) using the low-achievement method with one-off assessment suffers from several limitations (e.g., arbitrary cutoff, measurement error, lacking consideration of growth). The present study attempted to identify children with MLD usin... | 25,104,225 | [
-0.1682692,
0.5124876,
0.2946467,
-0.1015514,
0.3055135,
0.06861529,
-0.4847983,
-0.0791033,
0.1378449,
-0.1602831,
0.02863838,
0.2543868,
-0.3561214,
0.002443327,
-0.4712817,
0.3783762,
-0.1188271,
0.06727795,
-0.2725342,
-0.08307461,
0.3176102,
0.3531589,
0.1040299,
0... |
Diabetes mellitus and mortality from all-causes, cancer, cardiovascular and respiratory disease: evidence from the Health Survey for England and Scottish Health Survey cohorts. | Diabetes mellitus is associated with differing rates of all-cause and cause-specific mortality compared with the general population; although the strength of these associations requires further investigation. The effects of confounding factors, such as overweight and obesity and the presence of co-morbid cardiovascular... | 25,104,237 | [
-0.02445488,
-0.2356017,
-0.2185502,
-0.03052809,
-0.2461905,
-0.3650234,
-0.0531078,
0.1479963,
-0.07053363,
0.1417704,
0.1019665,
0.2604876,
-0.01659231,
-0.2280003,
0.05272941,
-0.09138231,
0.1724013,
0.3162616,
0.1254822,
0.05175812,
-0.2124927,
0.2814424,
-0.1290439,... |
Exercise and sleep in aging: emphasis on serotonin. | Reductions in central serotonin activity with aging might be involved in sleep-related disorders in later life. Although the beneficial effects of aerobic exercise on sleep are not new, sleep represents a complex recurring state of unconsciousness involving many lines of transmitters which remains only partly clear des... | 25,104,243 | [
-0.2744271,
-0.01653007,
-0.05609018,
-0.07739375,
0.3576023,
-0.3629396,
-0.03763497,
-0.2108563,
0.03426998,
-0.1390894,
0.0719967,
-0.1781472,
-0.2351857,
-0.1783302,
-0.3935791,
-0.08685037,
-0.5932303,
0.2241548,
-0.1905369,
-0.1383572,
-0.3031127,
0.3275506,
-0.0836... |
Spectroscopic and structural insights on molecular assembly consisting high potential zinc phthalocyanine photosensitizer attached to PyC60 through non-covalent interaction. | Efforts to improve the ease of self-assembly formation through non-covalent interaction has led to the development of zinc phthalocyanine (zinc-2,9,16,23-tetra-tert-butyl phthalocyanine, i.e., ZnPc) as a high potential photosensitizer molecule towards C60 pyrrolidine tris-acid ethyl ester (PyC60) in toluene and 1,2-dic... | 25,104,284 | [
-0.008120813,
0.1288294,
0.08444722,
-0.07023956,
0.01117483,
-0.2240557,
-0.365189,
-0.07925098,
0.008389662,
0.04713859,
-0.09138866,
0.06898553,
-0.1899249,
-0.228506,
-0.6196002,
-0.3854648,
-0.1809975,
0.4354608,
0.09171937,
0.04656101,
0.2718684,
0.2744989,
0.058797... |
Mapping p53 mutations in low-grade glioma: a voxel-based neuroimaging analysis. | Brain tumor location has proved to be a prognostic factor that may be associated with features of neoplastic origin. Mutation of p53 is an atypical genetic change that occurs during tumorigenesis. Thus, a potential correlation may exist between tumor location and p53 status. The purpose of the current study was to iden... | 25,104,286 | [
-0.0675199,
0.1411878,
0.02079502,
-0.2527243,
-0.05551141,
-0.2644969,
-0.006062083,
-0.03564944,
-0.04271032,
0.1291784,
0.03463132,
0.1703975,
-0.3654552,
-0.2330593,
-0.2356791,
0.05483725,
0.06191906,
0.5041425,
0.2376568,
-0.0646863,
-0.07228204,
0.4803585,
-0.13774... |
Beryllium is an inhibitor of cellular GSK-3β that is 1,000-fold more potent than lithium. | Glycogen synthase kinase 3β (GSK-3β) is a key regulator in signaling networks that control cell proliferation, metabolism, development, and other processes. Lithium chloride is a GSK-3 family inhibitor that has been a mainstay of in vitro and in vivo studies for many years. Beryllium salt has the potential to act as a ... | 25,104,312 | [
-0.1012616,
-0.02164732,
-0.210332,
0.03730766,
-0.08968171,
-0.03876892,
-0.05666796,
0.156444,
-0.2247247,
0.04201999,
-0.2109291,
0.409475,
-0.09038389,
0.02017498,
-0.08475,
-0.1032994,
-0.1541107,
0.2179774,
-0.2748204,
0.2870445,
0.1524986,
0.5136912,
0.02929727,
... |
Abnormal white matter integrity in long-term abstinent alcohol dependent patients. | A number of diffusion tensor imaging (DTI) studies have reported substantial white matter (WM) abnormalities in alcohol-dependent patients. These studies were usually performed in recovering alcohol-dependent patients who had been abstinent for days to several weeks. The current study was designed to examine WM microst... | 25,104,315 | [
0.01114172,
0.3106994,
-0.2403127,
0.2017939,
0.392441,
-0.4148278,
-0.04960569,
0.2326275,
-0.2634478,
0.1404223,
0.2059408,
0.245654,
-0.1490846,
0.2481933,
-0.2952461,
-0.1039125,
-0.403713,
0.7715583,
-0.391735,
-0.2173565,
-0.1260292,
0.4363158,
-0.1177749,
0.02353... |
Overexpression of a dominant-negative mutant of SIRT1 in mouse heart causes cardiomyocyte apoptosis and early-onset heart failure. | SIRT1, a mammalian ortholog of yeast silent information regulator 2 (Sir2), is an NAD(+)-dependent protein deacetylase that plays a critical role in the regulation of vascular function. The current study aims to investigate the functional significance of deacetylase activity of SIRT1 in heart. Here we show that the ear... | 25,104,317 | [
0.04813033,
0.04455002,
-0.2194059,
0.07426629,
0.2734404,
0.1621937,
0.5671784,
0.207225,
0.1794966,
-0.05172,
0.1644048,
0.2366204,
-0.2320163,
0.08797697,
-0.346597,
0.03234161,
-0.3536685,
-0.1110759,
-0.01098112,
-0.2415341,
0.3650949,
0.6242896,
-0.3542987,
0.1990... |
Scoring the collective effects of SNPs: association of minor alleles with complex traits in model organisms. | It has long been assumed that most parts of a genome and most genetic variations or SNPs are non-functional with regard to reproductive fitness. However, the collective effects of SNPs have yet to be examined by experimental science. We here developed a novel approach to examine the relationship between traits and the ... | 25,104,319 | [
0.09767062,
-0.05755578,
0.02348742,
-0.2643762,
0.2301533,
-0.5118274,
-0.002799668,
0.08688246,
0.08271737,
-0.03788032,
-0.1154858,
0.3230161,
0.3715765,
0.325222,
-0.439739,
-0.08248674,
-0.237833,
-0.008658649,
0.1006118,
0.4485464,
0.06933325,
-0.01172587,
-0.281039... |
p16(INK4a) /Ki-67 co-expression specifically identifies transformed cells in the head and neck region. | p16(INK4a) immunohistochemical overexpression is an overall reliable surrogate marker of human papillomavirus (HPV)-associated head and neck squamous cell carcinomas (HNSCC). However, cases of ambiguous p16(INK4a) overexpression are regularly detected in the head and neck: p16(INK4a) expression can be observed in non-m... | 25,104,331 | [
-0.27584,
-0.07390103,
-0.4548746,
-0.2616423,
0.1031242,
-0.6479935,
-0.3167563,
0.1769044,
0.3776049,
0.5044178,
-0.1072776,
0.07122152,
-0.2501569,
-0.3606269,
-0.6809586,
-0.1276587,
0.02002566,
0.1663753,
-0.08666983,
-0.07435507,
0.4683236,
-0.1840026,
-0.158853,
... |
Discovery of biomarkers predictive of GSI response in triple-negative breast cancer and adenoid cystic carcinoma. | Next-generation sequencing was used to identify Notch mutations in a large collection of diverse solid tumors. NOTCH1 and NOTCH2 rearrangements leading to constitutive receptor activation were confined to triple-negative breast cancers (TNBC; 6 of 66 tumors). TNBC cell lines with NOTCH1 rearrangements associated with h... | 25,104,330 | [
-0.007313167,
-0.007855916,
-0.1453274,
-0.5590097,
-0.1757821,
0.2031591,
-0.1744689,
0.002403661,
0.3803396,
0.2892174,
0.1163472,
0.4702451,
-0.2697765,
-0.1619876,
-0.276277,
-0.1259557,
-0.3683031,
0.1790756,
-0.2648835,
0.1379258,
0.4140084,
-0.08812873,
0.09992345,... |
The spatiotemporal dynamics of chromatin protein HP1α is essential for accurate chromosome segregation during cell division. | Heterochromatin protein 1α (HP1α) is involved in regulation of chromatin plasticity, DNA damage repair, and centromere dynamics. HP1α detects histone dimethylation and trimethylation of Lys-9 via its chromodomain. HP1α localizes to heterochromatin in interphase cells but is liberated from chromosomal arms at the onset ... | 25,104,354 | [
0.05774755,
0.004746617,
-0.09340326,
-0.1870016,
-0.04949765,
-0.1543097,
-0.2885206,
0.2755562,
0.3169673,
0.05677781,
0.2986814,
0.1214472,
-0.1933165,
0.2230571,
-0.3947473,
-0.02619234,
-0.5794212,
-0.1099343,
0.1280074,
-0.201193,
0.08835779,
0.4311531,
-0.1072138,
... |
Motor neuron disease. SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy. | Spinal muscular atrophy (SMA) is a genetic disease caused by mutation or deletion of the survival of motor neuron 1 (SMN1) gene. A paralogous gene in humans, SMN2, produces low, insufficient levels of functional SMN protein due to alternative splicing that truncates the transcript. The decreased levels of SMN protein l... | 25,104,390 | [
0.1253096,
0.02102797,
-0.06387945,
-0.4477631,
0.06540418,
0.1134858,
0.02286587,
0.1560695,
0.1238814,
-0.3742501,
0.01789014,
0.2167139,
0.2271352,
-0.09642369,
-0.1967874,
-0.102298,
-0.3505339,
0.06997063,
-0.1700761,
0.3017958,
0.3110763,
0.2336048,
0.01185452,
-0... |
Design and synthesis of 4'-O-alkyl-chitobiosyl-4-methylumbelliferone as human chitinase fluorogenic substrates. | The synthesis of three fluorogenic chitobiosyl derivatives, modified at the non-reducing 4'-OH with, either a methyl, an isopropyl or a cyclohexylmethyl substituent, is described. The 4'-capped 4-methylumbelliferyl chitobiosides are hydrolysed by the human chitinase CHIT1 following Michaelis-Menten kinetics and in cont... | 25,104,395 | [
-0.2828487,
-0.133151,
-0.009214371,
-0.109063,
0.1028104,
-0.1967036,
-0.1166477,
0.1063639,
-0.1232592,
0.044202,
0.2147738,
-0.07886169,
0.186386,
-0.12656,
-0.4828977,
0.2041108,
-0.7758035,
0.4418863,
-0.122194,
0.2150568,
0.4039196,
-0.03474562,
-0.2883024,
-0.125... |
Design and characterization of a handheld multimodal imaging device for the assessment of oral epithelial lesions. | A compact handpiece combining high resolution fluorescence (HRF) imaging with optical coherence tomography (OCT) was developed to provide real-time assessment of oral lesions. This multimodal imaging device simultaneously captures coregistered en face images with subcellular detail alongside cross-sectional images of t... | 25,104,410 | [
0.0330005,
-0.1532502,
-0.2883876,
-0.1266693,
-0.09654105,
-0.1621624,
0.1081252,
0.1124134,
0.261692,
0.08084384,
-0.1021079,
-0.1601323,
0.1230215,
-0.102678,
-0.46632,
-0.2896619,
-0.2673174,
-0.04417254,
0.04314685,
-0.1291046,
0.2369609,
0.3046097,
-0.1800634,
0.3... |
Label-free photoacoustic nanoscopy. | Super-resolution microscopy techniques - capable of overcoming the diffraction limit of light - have opened new opportunities to explore subcellular structures and dynamics not resolvable in conventional far-field microscopy. However, relying on staining with exogenous fluorescent markers, these techniques can sometime... | 25,104,412 | [
0.01630112,
0.04810621,
-0.3426514,
0.1628876,
0.003956179,
-0.2113046,
-0.02764182,
0.1868779,
0.3872886,
-0.03995564,
0.05326779,
-0.2772291,
0.1067011,
-0.1328656,
-0.4469004,
0.09732015,
-0.4965728,
-0.04169612,
-0.03698583,
0.1056168,
0.3554921,
0.1196435,
-0.3272779... |
Does age of onset of risk behaviors mediate the relationship between child abuse and neglect and outcomes in middle adulthood? | Child maltreatment has been linked with a number of risk behaviors that are associated with long-lasting maladaptive outcomes across multiple domains of functioning. This study examines whether the ages of onset of four risk behaviors-sexual intercourse, alcohol use, drug use, and criminal behavior-mediate the relation... | 25,104,419 | [
-0.3768758,
0.5582346,
-0.206138,
-0.08493209,
0.1420741,
-0.3358197,
-0.2997245,
0.06379465,
-0.03742205,
0.04099254,
0.04523324,
-0.07881261,
-0.04874797,
-0.1040923,
0.2886418,
-0.2691986,
0.07871853,
0.2870586,
0.09636702,
-0.0248604,
0.1750523,
0.1870051,
-0.1824725,... |
Development of gold nanoparticle-sheathed glass capillary nanoelectrodes for sensitive detection of cerebral dopamine. | To develop in vivo monitoring strategies of neurotransmitters involved in brain chemistry is a challenging work for progress in understanding the roles that biomolecules play in pathology and physiology. Here we report a new type of gold nanoparticle-sheathed glass capillary nanoelectrode (Au/GCNE) for sensing cerebral... | 25,104,436 | [
0.1255915,
0.05681767,
-0.2369742,
0.07980631,
0.08744603,
0.04774107,
-0.247745,
-0.07922757,
0.1760116,
0.1922982,
0.03779191,
-0.05715297,
0.1046866,
-0.02448955,
-0.2821476,
0.1389078,
-0.4221964,
-0.0219391,
0.1883858,
0.01175532,
0.2433846,
0.1602959,
-0.1673637,
... |
Target network differences between western drugs and Chinese herbal ingredients in treating cardiovascular disease. | Western drugs have achieved great successes in CVDs treatment. However, they may lead to some side effects and drug resistance. On the other hand, more and more studies found that Traditional Chinese herbs have efficient therapeutic effects for CVDs, while their therapeutic mechanism is still not very clear. It may be ... | 25,104,437 | [
-0.185199,
0.105513,
0.1248371,
-0.01330419,
0.1852406,
0.00761813,
-0.03325273,
0.3969197,
0.2325096,
0.4074064,
-0.04169942,
0.4597158,
0.015853,
0.06689544,
-0.4235473,
-0.08838145,
-0.4459537,
0.2565938,
-0.3552639,
0.5072066,
0.09835344,
0.3940157,
-0.3546104,
-0.0... |
An updated view on the differentiation of stem cells into endothelial cells. | Endothelial cells form the internal barrier between circulating blood and the vessel wall. They regulate arterial activity and mediate pathological reactions to vascular injuries such as atherosclerosis and balloon angioplasty. The development and differentiation of endothelial cells is a complex and coordinated proces... | 25,104,448 | [
-0.2634147,
-0.1210386,
0.04311272,
-0.237209,
0.08232304,
-0.1492977,
0.01786361,
0.1601321,
0.1109384,
0.3410689,
0.1525955,
0.03532308,
-0.1027574,
-0.009566603,
-0.4347472,
0.007839786,
-0.4305099,
-0.006773723,
-0.2845815,
0.078206,
0.2058455,
0.2209293,
-0.1434965,
... |
Correlation between the activity of the autonomic nervous system and endothelial function in patients with acute coronary syndrome. | The endothelium and sympathetic nervous system play an important role in the pathogenesis of acute coronary syndrome (ACS). The aim of our study was to evaluate correlations between noninvasive markers of the endothelial function and the sympathetic nervous system in patients with a recent ACS. The study included 52 pa... | 25,104,470 | [
0.1175135,
-0.1378588,
-0.1518686,
-0.05142932,
0.05839375,
-0.3546742,
-0.0193979,
-0.2469825,
-0.08257481,
0.1830703,
-0.04368455,
0.05429322,
-0.143497,
0.04522333,
-0.2356104,
-0.2309205,
-0.4771871,
0.0001628566,
-0.06667595,
0.1257905,
0.1332099,
0.01688875,
-0.0484... |
Ovulation induction in pre-pubertal Sahiwal-Friesian cross bred heifers by the use of clomiphene citrate and hCG. | In this study, an attempt was made to induce ovulation in crossbred pre-pubertal heifers by the use of clomiphene citrate (an anti-estrogen) and hCG. The hypothesis was that the clomiphene citrate, being anti-estrogen, would remove negative feedback effect of estrogen on the release of pituitary gonadotropins. Elevated... | 25,104,473 | [
0.005825991,
0.3809309,
0.1170097,
-0.2478278,
0.2261128,
-0.2220748,
-0.2082486,
0.02350954,
-0.02502943,
-0.16673,
-0.1030091,
0.5293419,
0.2370816,
-0.182479,
-0.614549,
-0.2112188,
-0.2254066,
-0.00965206,
-0.1448599,
-0.02104669,
-0.223277,
0.2266398,
-0.1386609,
-... |
Region- and age-dependent reductions of hippocampal long-term potentiation and NMDA to AMPA ratio in a genetic model of Alzheimer's disease. | To characterize the mechanisms underlying region- and age-dependent hippocampal synaptic dysfunction in Alzheimer's disease, we used transgenic CRND8 mice, expressing the Swedish-Indiana APP mutation. In 2-month-old mice, no β-amyloid plaques deposition, but the presence of soluble oligomers, were found in CA1 area but... | 25,104,560 | [
0.1787308,
-0.08381908,
-0.2910668,
-0.3215696,
-0.06856237,
-0.1092313,
0.05332422,
-0.07919939,
0.2417683,
0.2031519,
-0.1692796,
0.3355131,
0.1587287,
-0.07937379,
-0.05841993,
0.03619218,
-0.488144,
-0.1022754,
0.005641875,
0.3018273,
0.1195665,
0.3591253,
0.1369992,
... |
Genomics of cellulolytic bacteria. | The heterogeneous plant biomass is efficiently decomposed by the interplay of a great number of different enzymes. The enzyme systems in cellulolytic bacteria have been investigated by sequencing and bioinformatic analysis of genomes from plant biomass degrading microorganisms with valuable insights into the variety of... | 25,104,562 | [
0.07886672,
-0.04278701,
0.1005539,
0.1001599,
0.009432027,
-0.1578447,
-0.1409983,
0.02593358,
0.06079918,
-0.02426747,
0.1588243,
-0.2515999,
-0.2896858,
-0.02602031,
-0.5183762,
0.1322404,
-0.3659966,
0.2150471,
0.2088806,
-0.0168929,
0.1415187,
0.4625694,
-0.2642296,
... |
The drug and vaccine landscape for neglected diseases (2000-11): a systematic assessment. | In 1975-99, only 1·1% of new therapeutic products had been developed for neglected diseases. Since then, several public and private initiatives have attempted to mitigate this imbalance. We analysed the research and development pipeline of drugs and vaccines for neglected diseases from 2000 to 2011. We searched databas... | 25,104,602 | [
-0.2146149,
0.305849,
0.3614476,
-0.2414584,
-0.104693,
-0.1691705,
-0.06625109,
0.2155798,
-0.03590456,
-0.1776056,
0.08194465,
0.03832888,
0.03380013,
0.09662531,
-0.4801956,
-0.09688859,
-0.1125263,
0.1642373,
-0.06014016,
0.05972021,
0.06630211,
0.3056337,
-0.09709169... |
Management of somatic pain induced by head and neck cancer treatment: pain following radiation therapy and chemotherapy. Guidelines of the French Otorhinolaryngology Head and Neck Surgery Society (SFORL). | The authors present the section of the guidelines of the French Otorhinolaryngology Head and Neck Surgery Society (SFORL) for the management of somatic pain induced by head and neck cancer treatment concerning management of pain following radiation therapy and chemotherapy. A multidisciplinary work group was entrusted ... | 25,104,641 | [
-0.05319407,
-0.08234125,
-0.01910839,
-0.1741973,
-0.005269624,
-0.5732432,
-0.1593254,
0.01440025,
-0.1361923,
0.1802509,
0.1501016,
0.007938565,
-0.2912112,
-0.6398793,
-0.02172785,
-0.198986,
-0.1156492,
0.01388866,
0.03598426,
0.160446,
-0.08239593,
0.003651587,
-0.2... |
Caffeic acid directly targets ERK1/2 to attenuate solar UV-induced skin carcinogenesis. | Caffeic acid (3,4-dihydroxycinnamic acid) is a well-known phenolic phytochemical present in coffee and reportedly has anticancer activities. However, the underlying molecular mechanisms and targeted proteins involved in the suppression of carcinogenesis by caffeic acid are not fully understood. In this study, we report... | 25,104,643 | [
0.08333366,
-0.06390215,
0.02597613,
0.1006417,
0.1171654,
0.0182997,
-0.2680765,
0.2344614,
0.3210714,
0.05118864,
0.1600806,
0.1698763,
-0.06702138,
-0.0826367,
-0.1876248,
0.2375372,
0.03974869,
0.001615597,
-0.1637982,
-0.2595847,
0.1410153,
0.3749018,
-0.2837267,
-... |
Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis. | Numerous population-based studies of age-related macular degeneration have been reported around the world, with the results of some studies suggesting racial or ethnic differences in disease prevalence. Integrating these resources to provide summarised data to establish worldwide prevalence and to project the number of... | 25,104,651 | [
-0.04245094,
-0.2285138,
-0.001615797,
-0.1767038,
0.08142447,
-0.4426848,
0.225512,
-0.0631167,
0.1058542,
-0.1990842,
-0.03930244,
-0.04453892,
0.06342117,
-0.07416971,
-0.06638376,
-0.2780848,
-0.1810712,
0.3680253,
0.1308887,
-0.2324596,
0.1543086,
0.5633432,
-0.25799... |
Malaria burden and control in Bangladesh and prospects for elimination: an epidemiological and economic assessment. | Malaria is endemic in 13 of 64 districts in Bangladesh. About 14 million people are at risk. Some evidence suggests that the prevalence of malaria in Bangladesh has decreased since the the Global Fund to Fight AIDS, Tuberculosis and Malaria started to support the National Malaria Control Program (NMCP) in 2007. We did ... | 25,104,666 | [
-0.1347059,
0.1884949,
0.1075935,
0.1276385,
0.1183494,
-0.1667331,
-0.1652025,
-0.1296134,
-0.04821015,
-0.09274893,
-0.06357405,
0.08443177,
0.1045599,
0.5666171,
-0.3379163,
-0.1218752,
-0.06975202,
0.25009,
-0.04136604,
-0.100082,
0.1013741,
0.5863121,
-0.08203591,
... |
Dental photography in record keeping and litigation. | Dental photography is essential in record keeping and it is important for all members of the dental team to be appropriately trained and for each practice to have the appropriate equipment. This article provides an overview of the applications of dental photography and equipment, and highlights issues of consent and du... | 25,104,693 | [
-0.1841414,
0.256048,
-0.09772565,
-0.03216733,
-0.16577,
-0.09758167,
-0.09367592,
-0.1481539,
0.0472656,
-0.1778994,
0.1680309,
-0.005073087,
-0.2068733,
0.03391001,
-0.3602525,
-0.1050959,
-0.1697584,
0.1998515,
-0.1221493,
-0.1887295,
0.2421055,
0.07905558,
-0.1216898... |
Herbicides as weed control agents: state of the art: I. Weed control research and safener technology: the path to modern agriculture. | The purpose of modern industrial herbicides is to control weeds. The species of weeds that plague crops today are a consequence of the historical past, being related to the history of the evolution of crops and farming practices. Chemical weed control began over a century ago with inorganic compounds and transitioned t... | 25,104,723 | [
-0.3261388,
0.341224,
0.04768165,
0.0000886789,
0.09680717,
-0.2306908,
-0.5700052,
0.1070581,
0.08896025,
-0.1373085,
0.1517047,
0.04620435,
0.008211511,
-0.2976998,
-0.2452574,
-0.03394895,
-0.2673025,
0.2567462,
0.1741299,
0.09973497,
-0.23366,
0.3097112,
-0.4430996,
... |
Natural variation of root traits: from development to nutrient uptake. | The root system has a crucial role for plant growth and productivity. Due to the challenges of heterogeneous soil environments, diverse environmental signals are integrated into root developmental decisions. While root growth and growth responses are genetically determined, there is substantial natural variation for th... | 25,104,725 | [
0.2563437,
-0.1902522,
0.1575394,
0.1411647,
-0.03152043,
-0.3114371,
-0.2289467,
-0.1795131,
-0.05313638,
0.05361928,
0.02139511,
-0.105294,
-0.3216693,
-0.022098,
-0.4526795,
-0.078368,
-0.5554724,
0.2654194,
0.1011169,
-0.1320691,
0.164901,
0.3599931,
-0.2752391,
0.1... |
Effects of within-generation thermal history on the flight performance of Ceratitis capitata: colder is better. | The influence of thermal history on temperature-dependent flight performance was investigated in an invasive agricultural pest insect, Ceratitis capitata (Diptera: Tephritidae). Flies were exposed to one of four developmental acclimation temperatures (Tacc: 15, 20, 25, 30°C) during their pupal stage and tested at these... | 25,104,754 | [
0.2797755,
0.1071982,
-0.04420345,
0.01813994,
-0.1832771,
-0.3531115,
-0.08962244,
-0.03907783,
0.3672285,
-0.1589433,
0.04051163,
0.004717513,
0.03283808,
-0.08530989,
-0.5513834,
-0.1884961,
-0.1260398,
-0.06748132,
0.12627,
0.09632923,
-0.4678542,
0.3476251,
-0.163210... |
Screening of Lactobacillus strains of domestic goose origin against bacterial poultry pathogens for use as probiotics. | Lactobacilli are natural inhabitants of human and animal mucous membranes, including the avian gastrointestinal tract. Recently, increasing attention has been given to their probiotic, health-promoting capacities, among which their antagonistic potential against pathogens plays a key role. A study was conducted to eval... | 25,104,766 | [
-0.1646233,
-0.3118286,
0.2016403,
0.0001893159,
0.09820821,
0.1280838,
-0.1959738,
-0.04905737,
0.004881233,
-0.4119079,
0.07268261,
-0.02126824,
-0.3327218,
0.01541056,
-0.3575144,
0.1175165,
-0.4961623,
0.02666067,
-0.2806014,
-0.02362578,
0.3053976,
-0.02704358,
-0.01... |
Fly emergence from manure of Japanese quail fed thymol- or isoeugenol-supplemented diets. | Many problems in poultry production are caused by a combination of interrelated factors such as management, stress, nutrition, and exposure to pathogens. Saprophagous flies that develop in poultry manure are a potential route of pathogen transmission. Besides being a nuisance, defecation and regurgitation of flies soil... | 25,104,767 | [
-0.2544312,
0.2100319,
0.08447357,
-0.3701746,
-0.01902346,
-0.5115228,
-0.1299903,
-0.1797051,
0.0929504,
-0.5550437,
-0.09845903,
-0.3625153,
-0.2222966,
0.03098508,
-0.2556218,
0.3624672,
-0.8830808,
0.04588759,
0.355474,
0.1392585,
-0.427798,
0.143155,
-0.3456659,
0... |
Subjective well-being associated with size of social network and social support of elderly. | The current study examined the impact of size of social network on subjective well-being of elderly, mainly focused on confirmation of the mediator role of perceived social support. The results revealed that both size of social network and perceived social support were significantly correlated with subjective well-bein... | 25,104,778 | [
-0.2158182,
0.001041043,
0.2117422,
-0.06745893,
0.1936565,
-0.04107872,
-0.2353097,
0.128275,
-0.07356376,
-0.3754747,
0.03437085,
-0.2900784,
-0.06648469,
-0.03710572,
-0.1821821,
0.1153084,
-0.2274034,
0.3465497,
0.1608408,
0.003288973,
-0.2536786,
0.2437726,
0.0729819... |
A method for de novo nucleic acid diagnostic target discovery. | A proper target or marker is essential in any diagnosis (e.g. an infection or cancer). An ideal diagnostic target should be both conserved in and unique to the pathogen. Currently, these targets can only be identified manually, which is time-consuming and usually error-prone. Because of the increasingly frequent occurr... | 25,104,813 | [
-0.1487135,
-0.09863917,
-0.3175719,
0.01239534,
0.2601955,
-0.0611351,
-0.6011709,
0.4219826,
0.4370033,
-0.2212417,
-0.3219456,
-0.1190059,
0.08098996,
0.219028,
-0.6708823,
0.1744313,
-0.3164446,
0.04531276,
-0.2539034,
0.007059478,
0.4304914,
0.1965401,
-0.107274,
0... |
Despite substantial progress In EHR adoption, health information exchange and patient engagement remain low in office settings. | The United States is making substantial investments to accelerate the adoption and use of interoperable electronic health record (EHR) systems. Using data from the 2009-13 Electronic Health Records Survey, we found that EHR adoption continues to grow: In 2013, 78 percent of office-based physicians had adopted some type... | 25,104,827 | [
-0.3421526,
0.3084374,
0.1306598,
-0.1328714,
0.01224516,
-0.1516047,
-0.06694686,
-0.008022067,
-0.1455174,
-0.1047013,
0.06339192,
0.1392654,
-0.1191668,
-0.1258107,
-0.5652894,
-0.09594062,
-0.2084933,
0.1626115,
0.3468715,
-0.3229932,
-0.2805819,
-0.00002221193,
-0.28... |
Property damage and long-term psychological distress after the 2004 Niigata-Chuetsu earthquake in Ojiya, Japan: a community-based study. | This study aimed to assess psychological distress (PD) in earthquake-stricken communities with regard to the extent of property damage for 3 years following the 2004 Niigata-Chuetsu earthquake in Japan. Subjects were participants of health check examinations in a community near the epicentre, and included 7097 resident... | 25,104,841 | [
0.1193378,
0.04671267,
0.3594382,
-0.164121,
0.04717371,
0.06639452,
-0.06287308,
0.113539,
0.3712611,
0.1342445,
-0.1162687,
-0.3503467,
-0.05190763,
0.07366364,
-0.196513,
-0.1366903,
-0.329155,
0.522439,
0.4248562,
0.03386973,
-0.06138112,
0.166745,
0.09179326,
-0.17... |
Recursive and non-linear logistic regression: moving on from the original EuroSCORE and EuroSCORE II methodologies. | EuroSCORE II, despite improving on the original EuroSCORE system, has not solved all the calibration and predictability issues. Recursive, non-linear and mixed recursive and non-linear regression analysis were assessed with regard to sensitivity, specificity and predictability of the original EuroSCORE and EuroSCORE II... | 25,104,857 | [
0.07230834,
-0.2650195,
-0.3200718,
-0.1603199,
0.2141433,
-0.4424719,
-0.2031059,
0.002003291,
-0.03776856,
0.1321892,
0.2274591,
0.3977241,
-0.03432637,
0.003262974,
0.2287847,
-0.1005495,
-0.4394343,
0.2324043,
-0.01229622,
-0.01077926,
0.2248531,
-0.1149265,
0.1242781... |
The Role of Empowerment in a School-Based Community Service Program with Inner-City, Minority Youth. | Despite considerable fiscal and structural support for youth service programs, research has not demonstrated consistent outcomes across participants or programs, suggesting the need to identify critical program processes. The present study addresses this need through preliminary examination of the role of program empow... | 25,104,875 | [
-0.3211989,
0.3700235,
-0.1424597,
-0.1888641,
0.1834387,
-0.2932206,
-0.170564,
-0.09649529,
0.00179427,
0.02121054,
-0.1013094,
0.004830768,
-0.3309187,
-0.3891357,
-0.1431592,
-0.3470791,
-0.05230347,
0.2033063,
-0.4574672,
0.01849881,
-0.1893036,
0.2497708,
-0.124422,... |
Results of the treatment of the open femoral shaft fractures in children. | Intramedullary nailing has become the treatment of choice for closed femoral shaft fractures in children and adolescents. Immediate intramedullary nailing of open fractures of femur in children remains controversial, with most surgeons preferring to treat grade II or III open fractures either by debridement and tractio... | 25,104,890 | [
0.1177657,
0.1757397,
-0.08164418,
0.05535327,
0.06305988,
-0.2249939,
-0.3234372,
0.1730693,
-0.462661,
0.3080556,
0.243534,
0.0547736,
-0.4591256,
-0.2817141,
-0.1252229,
-0.2841405,
-0.1838542,
0.3033616,
-0.4509226,
-0.2364549,
0.4025643,
-0.2554334,
0.1871957,
0.27... |
Short-term evaluation of arthroscopic management of tennis elbow; including resection of radio-capitellar capsular complex. | There has been controversy regarding the pathogenesis and treatment of lateral epicondylitis. Different surgical techniques for the treatment of lateral epicondylitis prescribed. The purpose of this study was to evaluate the short-term outcomes of arthroscopic management including resection of the radio-capitellar caps... | 25,104,891 | [
0.1192208,
0.3071352,
0.3969034,
-0.2972498,
-0.1921034,
-0.6384454,
-0.2579299,
0.3535734,
0.2519973,
-0.1363731,
-0.01495589,
-0.2512092,
-0.1596785,
-0.159196,
-0.2374125,
-0.0708539,
0.1240051,
0.1192763,
-0.05825167,
-0.1658157,
-0.005794595,
0.2713798,
0.07482145,
... |
Automatic yield-line analysis of slabs using discontinuity layout optimization. | The yield-line method of analysis is a long established and extremely effective means of estimating the maximum load sustainable by a slab or plate. However, although numerous attempts to automate the process of directly identifying the critical pattern of yield-lines have been made over the past few decades, to date n... | 25,104,905 | [
0.2383924,
0.3404125,
-0.008467179,
0.1635962,
0.2447696,
-0.1904403,
-0.2503274,
-0.0612729,
0.2470565,
-0.2880488,
-0.02210192,
-0.5108793,
0.0973734,
0.2542018,
-0.4643061,
0.2223232,
-0.4129172,
0.2185979,
-0.009406049,
-0.03209466,
0.4300122,
-0.02206906,
-0.1329768,... |
Utilization of structural steel in buildings. | Over one-quarter of steel produced annually is used in the construction of buildings. Making this steel causes carbon dioxide emissions, which climate change experts recommend be reduced by half in the next 37 years. One option to achieve this is to design and build more efficiently, still delivering the same service f... | 25,104,911 | [
-0.3276618,
0.465762,
0.2553454,
0.2059569,
0.1205449,
0.0294329,
-0.2616199,
-0.05813761,
0.189102,
0.003255331,
-0.04538929,
-0.3858458,
0.116722,
-0.0313446,
-0.1260355,
-0.05054299,
0.1863996,
0.0389692,
-0.1932238,
0.07514977,
-0.03724942,
0.5274147,
-0.1917322,
-0... |
A prospective, randomized, double-blind, and multicenter trial of prophylactic effects of ramosetronon postoperative nausea and vomiting (PONV) after craniotomy: comparison with ondansetron. | Craniotomy patients have a high incidence of postoperative nausea and vomiting (PONV). This prospective, randomized, double-blind, multi-center study was performed to evaluate the efficacy of prophylactic ramosetron in preventing PONV compared with ondansetron after elective craniotomy in adult patients. A total of 160... | 25,104,916 | [
0.404541,
0.1201087,
0.08182261,
-0.5271645,
0.01827084,
-0.3518646,
-0.2068595,
-0.046757,
-0.04565743,
-0.3061631,
0.0534449,
0.1785379,
0.07627292,
-0.1915585,
0.1787127,
-0.06665015,
-0.5478063,
0.3234118,
-0.05138288,
-0.01269021,
-0.3715774,
0.2288654,
-0.1941071,
... |
GABAergic and glycinergic inhibitory synaptic transmission in the ventral cochlear nucleus studied in VGAT channelrhodopsin-2 mice. | Both glycine and GABA mediate inhibitory synaptic transmission in the ventral cochlear nucleus (VCN). In mice, the time course of glycinergic inhibition is slow in bushy cells and fast in multipolar (stellate) cells, and is proposed to contribute to the processing of temporal cues in both cell types. Much less is known... | 25,104,925 | [
-0.04054904,
-0.5236603,
-0.7113867,
-0.213482,
0.1713004,
-0.1538616,
-0.1805117,
-0.006005542,
-0.0012733,
0.2149124,
-0.1524511,
0.3842046,
-0.140295,
-0.06645096,
-0.2721581,
0.07267878,
-0.4836557,
0.1465704,
-0.1905322,
0.1234889,
0.2986041,
0.0927709,
0.1381069,
... |
Conductor gestures influence evaluations of ensemble performance. | Previous research has found that listener evaluations of ensemble performances vary depending on the expressivity of the conductor's gestures, even when performances are otherwise identical. It was the purpose of the present study to test whether this effect of visual information was evident in the evaluation of specif... | 25,104,944 | [
-0.06909272,
0.6811748,
-0.01055448,
-0.1240454,
0.121809,
-0.262107,
-0.2292476,
0.1742213,
0.1599814,
-0.2954679,
-0.409047,
0.1216268,
-0.03023705,
-0.1174748,
0.07664562,
-0.07605093,
0.02668314,
-0.03119119,
-0.2376035,
-0.3116834,
0.3695259,
0.1777018,
0.07413306,
... |
Thirteen-Week Study of PM014 Subchronic Oral Toxicity in Rats. | PM014 is a modified herbal formula based on Chung-Sang-Bo-Ha-Tang, which is a well-known prescription drug used for curing various inflammatory pulmonary diseases. We previously showed that PM014 attenuated lung inflammation in a murine model of chronic obstructive pulmonary disease (COPD). The objective of the present... | 25,104,964 | [
0.00162536,
-0.1192885,
0.2157882,
0.05961787,
0.3210647,
-0.1693925,
0.05810636,
0.1214908,
0.3822753,
-0.4335126,
-0.1737095,
0.1115176,
0.295895,
-0.01394388,
-0.6823212,
0.2989576,
-0.1891925,
0.3099236,
0.3100607,
0.1219924,
-0.02284203,
0.3626294,
-0.2399763,
-0.3... |
HCV RNA viral load is independent from CD4 cell count and plasma HIV RNA viral load in immunocompetent HIV-HCV co-infected patients: a 3-years follow-up study. | HCV RNA viral load is an important predictor of sustained virological response and, recently, a significant correlation with liver fibrosis was described. We investigated on possible influence of clinical and viro-immunological variables on HCV viral load in HIV-HCV co-infected patients over a study time of three years... | 25,104,966 | [
0.0008749333,
0.06628262,
-0.4702575,
-0.2242616,
-0.1049603,
-0.357289,
-0.192378,
0.264044,
-0.02318243,
0.00014766,
-0.08560432,
0.3649155,
0.04701877,
0.2980273,
-0.2846738,
-0.2980392,
0.1783305,
-0.146818,
-0.1222156,
0.3702966,
-0.1274559,
0.2090694,
0.01761179,
... |
The effectiveness of lasers in the treatment of onychomycosis: a systematic review. | Onychomycosis is a common nail pathology which has proven to be a treatment challenge to healthcare professionals. Antifungal drugs have been the mainstay of therapy for many years. Recently, laser technologies have been introduced as a treatment for onychomycosis avoiding the disadvantages of systemic and topical drug... | 25,104,974 | [
0.05757648,
-0.08311114,
0.2385039,
0.04366679,
0.01729101,
-0.2829308,
-0.1663539,
-0.01776036,
-0.007298185,
-0.3640718,
0.1046906,
0.04206436,
0.09839386,
-0.002142895,
0.07725158,
-0.2440116,
-0.05974166,
0.1169739,
-0.1138438,
-0.3104276,
-0.1642573,
0.2385681,
-0.04... |
Oxytocin ameliorates the immediate myocardial injury in heart transplant through down regulation of the neutrophil dependent myocardial apoptosis. | Cardiac oxytocin (OT) is structurally identical to that found in the hypothalamus, which thereby indicates that cardiac OT is derived from the same gene and is an active form of OT. The abundance of OT and OT receptors in atrial myocytes shows that, directly and/or via the release of the cardiac hormone atrial natriure... | 25,104,981 | [
0.02572537,
-0.04169193,
-0.2930198,
-0.4024312,
-0.04021433,
-0.4885135,
-0.3340717,
-0.04958919,
-0.02286529,
-0.1455141,
-0.004394793,
-0.08701199,
-0.1005614,
0.1580394,
-0.2923026,
-0.2751343,
-0.3387553,
-0.1195739,
-0.1910042,
0.008783952,
-0.05639785,
0.220151,
-0... |
Beneficial role of antioxidants on clinical outcomes and erythrocyte antioxidant parameters in rheumatoid arthritis patients. | This study aims to investigate the effect of antioxidants supplement on clinical outcomes and antioxidant parameters in rheumatoid arthritis (RA). The pre-post study was conducted on 40 female patients with RA in 12 weeks that taken daily one Selenplus capsule contained 50 μg selenium, 8 mg zinc, 400 μg vitamin A, 125 ... | 25,104,994 | [
-0.003152868,
0.1664813,
-0.03986622,
-0.1175488,
0.04623573,
-0.2012712,
-0.03829668,
0.07959613,
-0.05485151,
-0.1980247,
0.340778,
0.1624729,
0.1237438,
0.1488625,
0.05747843,
0.1779259,
-0.006119006,
0.2117457,
0.1834052,
0.3833525,
-0.1598188,
0.297517,
-0.0899636,
... |
Regulation of fatty acid composition and lipid storage by thyroid hormone in mouse liver. | Thyroid hormones (THs) are potent hormones modulating liver lipid homeostasis. The perturbation of lipid homeostasis is a hallmark of non-alcoholic fatty liver disease (NAFLD), a very common liver disorder. It was reported that NAFLD patients were associated with higher incidence of hypothyroidism. However, whether abn... | 25,105,012 | [
0.07150358,
-0.07717112,
-0.07901517,
-0.1476605,
0.2146455,
-0.02857355,
0.1926426,
0.2778269,
-0.1735169,
0.1496716,
0.00809703,
0.2831703,
0.04435916,
-0.114385,
-0.09473471,
-0.07374282,
0.08461618,
-0.010347,
0.03167918,
0.1968273,
-0.2394723,
0.2359463,
-0.3866238,
... |
Evaluation of the endothelial cell density and the central corneal thickness in pseudoexfoliation syndrome and pseudoexfoliation glaucoma. | Purpose. Evaluation of central corneal thickness (CCT) and endothelial cell density (ECD) in patients with senile cataract and coexisting pseudoexfoliation (PEX) syndrome with glaucoma (PEXG) and without glaucoma using specular microscopy. Participants and Methods. The study included 122 patients (217 eyes). In this gr... | 25,105,017 | [
0.3439814,
0.1703278,
0.2048365,
0.06591246,
-0.07881357,
-0.01430782,
0.3388076,
0.1894259,
0.1682483,
0.271144,
-0.07357952,
-0.1402661,
-0.717739,
0.002008279,
-0.3438844,
-0.005570762,
-0.4195186,
0.2673997,
-0.0523227,
0.09417448,
-0.2562463,
0.326968,
0.2872188,
-... |
Complicated gallstones after laparoscopic sleeve gastrectomy. | The natural history of gallstone formation after laparoscopic sleeve gastrectomy (LSG), the incidence of symptomatic gallstones, and timing of cholecystectomy are not well established. A retrospective review of prospectively collected database of 150 patients that underwent LSG was reviewed. Preoperatively, gallbladder... | 25,105,023 | [
0.09816791,
0.003040792,
-0.5098993,
0.004285853,
-0.08801368,
-0.1055934,
-0.02257245,
-0.1811068,
0.005554678,
0.05153058,
0.05321303,
0.03553844,
-0.1833182,
-0.1829509,
-0.1918527,
-0.21244,
-0.2164443,
0.3795775,
0.4782666,
-0.1706126,
0.08948851,
0.3706507,
-0.20457... |
Prevalence of Voluntary Counseling and Testing Utilization and Its Associated Factors among Bahirdar University Students. | Background. In Ethiopia university students are among the most sexually active and high HIV risk young population group but unfortunately VCT uptake was low (35%-38%) among this group. Examining the factors contributing to VCT uptake is vital to facilitate HIV prevention and control efforts. Objective. To assess the pr... | 25,105,028 | [
0.02560379,
0.08245462,
0.07858069,
0.05851518,
0.5283585,
-0.3345433,
-0.195604,
0.1131339,
-0.05864444,
0.01695204,
0.3396454,
0.1634347,
-0.07062803,
0.2232296,
-0.4735253,
-0.1739553,
-0.2073294,
0.114303,
-0.01830652,
0.09625745,
0.08574358,
0.5979026,
-0.05554284,
... |
Body stalk anomaly in a 9-week pregnancy. | Body stalk anomaly is a rare and severe malformation syndrome in which the exact pathophysiology and trigger factors are still unknown. This is a case of a 30-year-old patient who underwent ultrasound at 9 weeks of gestation. It revealed an abnormal location of the inferior body of the embryo in the coelomic space. The... | 25,105,039 | [
-0.02715882,
0.01992753,
0.2117892,
0.0359546,
0.5503375,
-0.2361585,
-0.1794933,
-0.423813,
0.2405036,
0.1332138,
0.0413539,
0.156663,
-0.1852554,
-0.1858657,
-0.1215983,
-0.02581032,
-0.7558885,
0.05593695,
-0.2279246,
-0.5541831,
0.3244311,
0.4119288,
-0.06729011,
0.... |
Genome analysis of the staphylococcal temperate phage DW2 and functional studies on the endolysin and tail hydrolase. | This study describes the genome of temperate <iSiphoviridae</i phage DW2, which is routinely propagated on <iStaphylococcus aureus</i DPC5246. The 41941 bp genome revealed an open reading frame (ORF1) which has a high level of homology with members of the resolvase subfamily of site-specific serine recombinase, involve... | 25,105,056 | [
-0.1508471,
-0.1829542,
-0.1525912,
-0.2801165,
-0.08289839,
-0.1890105,
0.1273501,
-0.1119474,
0.3196643,
-0.1184437,
-0.04109094,
-0.03234029,
-0.1482789,
-0.1709132,
-0.5062411,
0.2515763,
-0.5974937,
0.00486879,
0.200143,
0.2470878,
0.2833973,
0.5047854,
-0.2905853,
... |
Potency and Stability of Intradermal Capsaicin: Implications for Use as a Human Model of Pain in Multicenter Clinical Trials. | Intradermally injected capsaicin has been used extensively both as a human pain model and to assess analgesic efficacy. Factors such as dose, formulation, route, and site are known to affect its sensitivity. We determined whether potency and stability of capsaicin solutions were further sources of variability when foll... | 25,105,064 | [
0.001763666,
0.2018,
-0.2460105,
-0.2273209,
-0.08635006,
-0.1906638,
-0.2082889,
0.3107071,
0.2736453,
-0.7976213,
0.2613732,
-0.4087539,
-0.1826607,
-0.2396014,
-0.2350941,
-0.09521961,
-0.35433,
-0.09477583,
0.1761844,
-0.02312323,
0.1572562,
0.2251123,
-0.10792,
0.1... |
Stress resilience training: the need for circumspection. | Weltman et al have presented a fascinating report on the effectiveness of a stress resilience training program on police department personnel (Global Adv Health Med. 2014;3(2):72-79). Certainly at first reading there appears to be strong evidence of the effectiveness of the program. However, careful evaluation of the m... | 25,105,068 | [
-0.3751961,
-0.06176353,
0.1307339,
0.08619136,
-0.1678439,
-0.1372134,
-0.1227649,
-0.4011777,
0.1198771,
-0.04695442,
0.02792393,
-0.2835313,
-0.190112,
-0.3107576,
-0.08469854,
-0.2710796,
-0.280798,
0.4845264,
0.1291296,
-0.1293076,
0.09991044,
-0.07705057,
-0.0477108... |
Exploring the economic and social effects of care dependence in later life: protocol for the 10/66 research group INDEP study. | In low or middle income countries chronic diseases are rapidly becoming the main cause of disease burden. However, the main focus of health policymakers has been on preventing death from cancer and heart disease, with very little attention to the growing problem of long-term needs for care (dependence). Numbers of depe... | 25,105,086 | [
-0.2166686,
-0.02662482,
0.3202455,
-0.132102,
0.1566792,
-0.05781114,
-0.03707797,
0.1926357,
-0.04645054,
-0.09309929,
-0.3852442,
-0.2807682,
-0.1699296,
0.1199552,
-0.2942336,
-0.07894675,
-0.1498138,
0.09858538,
-0.2044138,
0.1249153,
0.2318649,
0.4080669,
0.1337331,... |
Long-Term Disease Control with Triapine-Based Radiochemotherapy for Patients with Stage IB2-IIIB Cervical Cancer. | National Cancer Institute phase I #7336 and phase II #8327 clinical trials explored the safety and efficacy of triapine (NSC #663249) added to cisplatin radiochemotherapy in untreated patients with advanced-stage cervical cancer. Triapine inhibits ribonucleotide reductase, the rate-limiting enzyme responsible for DNA-b... | 25,105,092 | [
0.2042312,
-0.1907308,
-0.2509305,
-0.4418296,
0.1292945,
-0.1406375,
-0.07517257,
0.1152082,
0.3546013,
0.2408797,
-0.1708487,
0.05360061,
-0.05610977,
0.3400301,
-0.110691,
-0.2290102,
-0.0214777,
0.1249634,
-0.00598578,
0.4249785,
0.1740397,
0.5277493,
-0.0769946,
0.... |
A case of retinal tear associated with use of sorafenib. | Inhibition of angiogenesis is a target in the treatment of a variety of malignancies. Sorafenib is an oral inhibitor of multiple tyrosine kinases involved in tumor angiogenesis. A related case of ophthalmologic toxicity has been reported with another vascular endothelial growth factor receptor inhibitor, sunitinib. We ... | 25,105,094 | [
-0.09936088,
-0.07265553,
0.0555976,
-0.3884409,
-0.03717187,
-0.3449993,
-0.1008271,
0.03079764,
0.0150141,
0.0780828,
0.2379632,
0.2175689,
-0.3858456,
-0.2889531,
-0.1636572,
-0.03505695,
-0.3552258,
-0.02486461,
0.1773232,
-0.1371099,
-0.1175299,
0.3269224,
-0.0743478... |
Pregnancy-associated pulmonary embolism during the peripartum period: An 8-year experience at a single center. | The purpose of this study was to estimate the incidence, timing of onset, risk factors, and mortality rate of pregnancy-associated pulmonary embolism (PAPE). We analyzed PAPE cases that occurred between January 2005 and December 2012 at Cheil General Hospital & Women's Healthcare Center. Those cases that were not c... | 25,105,098 | [
0.03265379,
0.1072367,
-0.1819736,
0.1771662,
0.3172495,
-0.05982768,
-0.3319719,
0.1004059,
-0.2853484,
0.04727848,
0.1090449,
0.4064711,
-0.03109217,
-0.1827516,
0.4585735,
0.044692,
0.05412103,
0.04121868,
0.250497,
-0.3545023,
0.390022,
0.4028558,
-0.2076856,
0.2014... |
Tumor-infiltration of T-lymphocytes is inversely correlated with clinicopathologic factors in endometrial adenocarcinoma. | The aim of this study was to determine the distribution of T-lymphocytes and their relationship with clinicopathologic factors in endometrial carcinoma. Samples were collected from 89 patients with endometrial endometrioid adenocarcinoma treated in Pusan National University Hospital from 2004 to 2011. Normal endometria... | 25,105,099 | [
0.07450088,
0.0874198,
-0.3773012,
0.003363528,
-0.2013445,
-0.1455319,
0.2332523,
0.2727087,
0.01891309,
0.07281355,
-0.1592113,
0.2431341,
0.09749894,
0.06677853,
-0.2642915,
-0.1101747,
-0.04471526,
0.1736833,
0.09547205,
0.06402106,
0.1063156,
0.4444222,
-0.01456739,
... |
The expression of FAS-associated factor 1 and heat shock protein 70 in ovarian cancer. | In this study, we evaluated the expression of FAS-associated factor 1 (FAF1) and heat shock protein 70 (HSP70) in normal ovary and ovarian cancer, and also analyzed the correlation between FAF1 and HSP70 in ovarian cancer. The patient group consisted of 29 unrelated Korean women diagnosed as ovarian cancers and control... | 25,105,101 | [
-0.04755976,
-0.09460755,
-0.02765907,
-0.2637868,
0.3550946,
-0.3168653,
0.3210405,
0.2669232,
0.4634417,
0.2898424,
0.3167785,
0.05838773,
-0.04994262,
-0.316831,
0.3244875,
-0.504709,
-0.1101477,
-0.1388295,
0.1249583,
-0.03410476,
0.1366625,
0.1718512,
-0.5793743,
0... |
Comparison of two methods of RNA extraction from formalin-fixed paraffin-embedded tissue specimens. | The present study aimed to compare two different methods of extracting RNA from formalin-fixed paraffin-embedded (FFPE) specimens of diffuse large B-cell lymphoma (DLBCL). We further aimed to identify possible influences of variables--such as tissue size, duration of paraffin block storage, fixative type, primers used ... | 25,105,117 | [
-0.2564929,
0.2333253,
-0.2656024,
-0.4336263,
-0.1538152,
-0.4220218,
-0.005956175,
0.1905135,
-0.1959702,
0.3826541,
-0.0725392,
0.00181716,
0.3994283,
0.2887904,
-0.1240328,
-0.1514559,
0.1269428,
-0.1837525,
-0.3288895,
0.3701878,
-0.007268069,
0.03507194,
-0.2589081,... |
Adiponectin, leptin, and chemerin in elderly patients with type 2 diabetes mellitus: a close linkage with obesity and length of the disease. | Obesity, insulin resistance, and aging are closely associated and adipokines seem to have a crucial role in their pathophysiology. We aim to study the relationship between aging and chemerin, adiponectin, and leptin levels in type 2 diabetes mellitus (T2DM). Age correlated positively with chemerin and leptin and invers... | 25,105,135 | [
0.3077484,
-0.1517193,
0.07593356,
-0.09409509,
0.03975026,
-0.2320043,
-0.009715506,
0.245048,
0.08210623,
0.1535609,
0.1806666,
-0.07391419,
-0.220626,
-0.2226159,
-0.2491479,
-0.2135855,
-0.1915774,
0.2968808,
0.1566833,
0.076745,
-0.01642738,
0.1857345,
-0.1481579,
... |
The sirtuin 3 expression profile is associated with pathological and clinical outcomes in colon cancer patients. | To investigate the correlation between Sirtuin 3 (SIRT3) expression and the clinical outcome of patients with colon cancer. The tumor specimens from 127 patients with colon cancer were obtained for SIRT3 immunohistochemical staining. Patients were followed up. In in vitro study, SIRT3 gene was inhibited to observe the ... | 25,105,144 | [
0.1201145,
0.06105448,
-0.06555408,
0.0518649,
-0.263506,
-0.08680606,
-0.01178385,
0.2912673,
0.03756146,
-0.03436164,
0.2354297,
0.221291,
-0.01111944,
0.03611042,
-0.118603,
-0.1458818,
-0.2058511,
0.1167668,
-0.1296575,
0.08925495,
0.2349426,
0.4410097,
-0.04950069,
... |
Culturable bacterial microbiota of the stomach of Helicobacter pylori positive and negative gastric disease patients. | Human stomach is the only known natural habitat of Helicobacter pylori (Hp), a major bacterial pathogen that causes different gastroduodenal diseases. Despite this, the impact of Hp on the diversity and the composition of the gastric microbiota has been poorly studied. In this study, we have analyzed the culturable gas... | 25,105,162 | [
-0.1412857,
-0.3582611,
0.05002516,
0.09755058,
-0.1472211,
0.1987815,
-0.05676703,
0.107172,
0.1842594,
0.03569836,
0.1422955,
-0.1942217,
-0.2449623,
-0.4194286,
-0.3259308,
0.04234406,
-0.07754764,
0.2398857,
0.1614563,
-0.3179462,
0.06119619,
0.1255321,
-0.04609656,
... |
A local stability supported parallel distributed constraint optimization algorithm. | This paper presents a new distributed constraint optimization algorithm called LSPA, which can be used to solve large scale distributed constraint optimization problem (DCOP). Different from the access of local information in the existing algorithms, a new criterion called local stability is defined and used to evaluat... | 25,105,166 | [
0.1403542,
0.3153588,
0.1040458,
0.2972679,
0.2330371,
-0.3119577,
-0.1087886,
0.1486982,
0.2458812,
-0.09551579,
-0.1114109,
-0.1244995,
0.1127714,
0.187205,
-0.3594566,
-0.1413432,
-0.3052063,
-0.216838,
-0.1901611,
0.1157713,
-0.1030329,
-0.07143011,
-0.1227825,
0.10... |
Moving Beyond Neighborhood: Activity Spaces and Ecological Networks As Contexts for Youth Development. | Many scholars, policy analysts, and practitioners agree that neighborhoods are important contexts for urban youth. Yet, despite decades of research, our knowledge of why and how neighborhoods influence the day-to-day lives of youth is still emerging. Theories about neighborhood effects largely assume that neighborhoods... | 25,105,172 | [
-0.1538801,
0.1015455,
-0.001128806,
-0.08481587,
0.2301181,
-0.1632077,
-0.2979719,
0.1535417,
0.3186129,
-0.1303452,
-0.2605557,
-0.3742776,
-0.1197891,
-0.1807512,
-0.3649818,
-0.00804137,
-0.3291143,
0.09835419,
0.06100744,
0.0949437,
-0.1036069,
0.3206745,
-0.0086692... |
Magnetite-doped polydimethylsiloxane (PDMS) for phosphopeptide enrichment. | Reversible phosphorylation plays a key role in numerous biological processes. Mass spectrometry-based approaches are commonly used to analyze protein phosphorylation, but such analysis is challenging, largely due to the low phosphorylation stoichiometry. Hence, a number of phosphopeptide enrichment strategies have been... | 25,105,173 | [
0.04332582,
0.1125069,
-0.06019431,
-0.009877365,
-0.1534461,
-0.04610821,
-0.06461306,
0.5114127,
-0.02820561,
0.1992314,
-0.0594941,
0.09868036,
-0.1480741,
-0.3337963,
-0.4439848,
0.128049,
-0.2789402,
-0.1070989,
-0.244396,
0.04993602,
0.2502279,
0.08681925,
-0.028098... |
Deformable nature of various damaged DNA duplexes estimated by an electrochemical analysis on electrodes. | We report bending flexibility of damaged duplexes possessing an apurinic/apyrimidinic (AP) site analogue, a cyclobutane pyrimidine dimer (CPD), and a pyrimidine(6-4)pyrimidone photoproduct (6-4PP). Based on the electrochemical evaluation on electrodes, the duplex flexibilities of the lesions increased in the following ... | 25,105,179 | [
-0.06722436,
-0.1808311,
-0.1341708,
-0.002104581,
0.244238,
-0.08898942,
-0.3840221,
0.07378455,
0.6027862,
-0.07285116,
-0.02039796,
-0.06292859,
-0.0002328142,
0.05869734,
-0.4888295,
-0.01427939,
-0.599835,
0.2610665,
-0.259475,
0.2628008,
0.3446957,
0.0452101,
-0.312... |
Preparation of Mo nanopowders through electroreduction of solid MoS2 in molten KCl-NaCl. | Electrolysis of MoS2 to produce Mo nanopowders and elemental sulfur has been studied in an equimolar mixture of NaCl and KCl at 700 °C. The reduction mechanism was investigated by cyclic voltammetry (CV), potentiostatic and constant voltage electrolysis together with spectroscopic and scanning electron microscopic anal... | 25,105,181 | [
-0.01688456,
-0.03928722,
-0.157372,
-0.2302445,
-0.05309299,
0.02524388,
-0.1327088,
-0.1910735,
-0.06261736,
-0.2287593,
-0.03318453,
0.1948773,
-0.08129651,
-0.02919746,
-0.3921009,
-0.1163182,
-0.2775439,
-0.1105161,
0.07005902,
0.062951,
0.3127691,
0.06346484,
-0.177... |
Plant maturity and nitrogen fertilization affected fructan metabolism in harvestable tissues of timothy (Phleum pratense L.). | Timothy (Phleum pratense L.) is an important grass forage used for pasture, hay, and silage in regions with cool and humid growth seasons. One of the factors affecting the nutritive value of this grass is the concentration of non-structural carbohydrates (NSC), mainly represented by fructans. NSC concentration depends ... | 25,105,233 | [
0.07860896,
0.02033705,
0.0798425,
0.08131083,
0.1487893,
-0.5618353,
-0.03183702,
-0.03082721,
0.01675635,
-0.1220543,
-0.03243688,
-0.3740835,
-0.0940018,
0.008521092,
-0.4224643,
-0.1700994,
-0.0225417,
0.2161734,
-0.02302175,
-0.01348746,
0.2615607,
0.503381,
-0.41236... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.