title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Diffusing-wave spectroscopy in an inhomogeneous object: local viscoelastic spectra from ultrasound-assisted measurement of correlation decay arising from the ultrasound focal volume. | We demonstrate diffusing-wave spectroscopy (DWS) in a localized region of a viscoelastically inhomogeneous object by measurement of the intensity autocorrelation [g(2)(τ)] that captures only the decay introduced by the temperature-induced Brownian motion in the region. The region is roughly specified by the focal volum... | 25,122,299 | [
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Self-similarity and scaling of thermal shock fractures. | The problem of crack pattern formation due to thermal shock loading at the surface of half space is solved numerically using the two-dimensional boundary element method. The results of numerical simulations with 100-200 random simultaneously growing and interacting cracks are used to obtain scaling relations for crack ... | 25,122,311 | [
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Healing of polymer interfaces: Interfacial dynamics, entanglements, and strength. | Self-healing of polymer films often takes place as the molecules diffuse across a damaged region, above their melting temperature. Using molecular dynamics simulations we probe the healing of polymer films and compare the results with those obtained for thermal welding of homopolymer slabs. These two processes differ f... | 25,122,327 | [
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Hidden scaling patterns and universality in written communication. | The temporal statistics exhibited by written correspondence appear to be media dependent, with features which have so far proven difficult to characterize. We explain the origin of these difficulties by disentangling the role of spontaneous activity from decision-based prioritizing processes in human dynamics, clocking... | 25,122,352 | [
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Nonequilibrium shock-heated nitrogen flows using a rovibrational state-to-state method. | A rovibrational collisional model is developed to study the internal energy excitation and dissociation processes behind a strong shock wave in a nitrogen flow. The reaction rate coefficients are obtained from the ab initio database of the NASA Ames Research Center. The master equation is coupled with a one-dimensional... | 25,122,371 | [
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Extension of the dielectric breakdown model for simulation of viscous fingering at finite viscosity ratios. | Immiscible displacement of viscous oil by water in a petroleum reservoir is often hydrodynamically unstable. Due to similarities between the physics of dielectric breakdown and immiscible flow in porous media, we extend the existing dielectric breakdown model to simulate viscous fingering patterns for a wide range of v... | 25,122,390 | [
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Three-dimensional coherent structures of electrokinetic instability. | A direct numerical simulation of the three-dimensional elektrokinetic instability near a charge-selective surface (electric membrane, electrode, or system of micro- or nanochannels) has been carried out and analyzed. A special finite-difference method has been used for the space discretization along with a semi-implici... | 25,122,393 | [
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Role of viscous friction in the reverse rotation of a disk. | The mechanical response of a circularly driven disk in a dissipative medium is considered. We focus on the role played by viscous friction in the spinning motion of the disk, especially on the effect called reverse rotation, where the intrinsic and orbital rotations are antiparallel. Contrary to what happens in the fri... | 25,122,402 | [
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Theory of ion transport with fast acid-base equilibrations in bioelectrochemical systems. | Bioelectrochemical systems recover valuable components and energy in the form of hydrogen or electricity from aqueous organic streams. We derive a one-dimensional steady-state model for ion transport in a bioelectrochemical system, with the ions subject to diffusional and electrical forces. Since most of the ionic spec... | 25,122,405 | [
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Multiscale dynamics of semiflexible polymers from a universal coarse-graining procedure. | Simulating the dynamics of a semiflexible polymer across time and length scales that bridge the rigid and flexible regimes requires a physically sound method for generating coarse-grained representations of the polymer. Here, we study the dynamic behavior of the discrete stretchable, shearable wormlike chain model, whi... | 25,122,407 | [
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Generalized modification in the lattice Bhatnagar-Gross-Krook model for incompressible Navier-Stokes equations and convection-diffusion equations. | In this paper, two modified lattice Boltzmann Bhatnagar-Gross-Krook (LBGK) models for incompressible Navier-Stokes equations and convection-diffusion equations are proposed via the addition of correction terms in the evolution equations. Utilizing this modification, the value of the dimensionless relaxation time in the... | 25,122,412 | [
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RET mutation and expression in small-cell lung cancer. | There is growing interest in defining the somatic mutations associated with small-cell lung cancer (SCLC). Unfortunately, a serious blockade to genomic analyses of this disease is a limited access to tumors because surgery is rarely performed. We used our clinical/pathologic database of SCLC patients to determine the a... | 25,122,427 | [
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Therapeutic priority of the PI3K/AKT/mTOR pathway in small cell lung cancers as revealed by a comprehensive genomic analysis. | The information regarding therapeutically relevant genomic alterations in small cell lung cancer (SCLC) is not well developed. We analyzed the SCLC genome using an integrative approach to stratify the targetable alterations. We performed whole exon sequencing (n = 51) and copy number analysis (n =47) on surgically rese... | 25,122,428 | [
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Gefitinib treatment in EGFR mutated caucasian NSCLC: circulating-free tumor DNA as a surrogate for determination of EGFR status. | In the phase IV, open-label, single-arm study NCT01203917, first-line gefitinib 250 mg/d was effective and well tolerated in Caucasian patients with epidermal growth factor receptor (EGFR) mutation-positive non-small-cell lung cancer (previously published). Here, we report EGFR mutation analyses of plasma-derived, circ... | 25,122,430 | [
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Re-evaluating the optimal radiation dose for definitive chemoradiotherapy for esophageal squamous cell carcinoma. | The optimal radiation dose for treating esophageal squamous cell carcinoma (ESCC) has long been debated. We evaluated if doses greater than 50.4 Gy delivered with modern techniques are beneficial in terms of tumor control, survival, and toxicity. We included 193 consecutive patients with ESCC treated with definitive co... | 25,122,435 | [
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Effects of aging on osteogenic response and heterotopic ossification following burn injury in mice. | Heterotopic ossification (HO) is a common and debilitating complication of burns, traumatic brain injuries, and musculoskeletal trauma and surgery. Although the exact mechanism of ectopic bone formation is unknown, mesenchymal stem cells (MSCs) capable of osteogenic differentiation are known to play an essential role. ... | 25,122,460 | [
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Surface physicochemistry and ionic strength affects eDNA's role in bacterial adhesion to abiotic surfaces. | Extracellular DNA (eDNA) is an important structural component of biofilms formed by many bacteria, but few reports have focused on its role in initial cell adhesion. The aim of this study was to investigate the role of eDNA in bacterial adhesion to abiotic surfaces, and determine to which extent eDNA-mediated adhesion ... | 25,122,477 | [
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A review of the Fukushima nuclear reactor accident: radiation effects on the thyroid and strategies for prevention. | This is a summary of the nuclear accident at the Tokyo Electric Power Company Fukushima Daiichi Nuclear Power Stations (FDNPS) on 11 March 2011 to be used as a review of the radiation effects to the thyroid and strategies of prevention. The amount of radioiodine released to the environment following the Fukushima accid... | 25,122,492 | [
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A maladaptive role for EP4 receptors in mouse mesangial cells. | Roles of the prostaglandin E2 E-prostanoid 4 receptor (EP4) on extracellular matrix (ECM) accumulation induced by TGF-β1 in mouse glomerular mesangial cells (GMCs) remain unknown. Previously, we have identified that TGF-β1 stimulates the expression of FN and Col I in mouse GMCs. Here we asked whether stimulation of EP4... | 25,122,504 | [
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Steered quantum dynamics for energy minimization. | We introduce a quantum optimal control algorithm for energy minimization that combines the diffeomorphic modulation under observable response preserving homotopy (D-MORPH) gradient and the Broyden Fletcher Goldfarb Shanno (BFGS) iterative scheme for nonlinear optimization. An extended set of controls defining the time-... | 25,122,515 | [
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Infrageneric phylogeny and temporal divergence of Sorghum (Andropogoneae, Poaceae) based on low-copy nuclear and plastid sequences. | The infrageneric phylogeny and temporal divergence of Sorghum were explored in the present study. Sequence data of two low-copy nuclear (LCN) genes, phosphoenolpyruvate carboxylase 4 (Pepc4) and granule-bound starch synthase I (GBSSI), from 79 accessions of Sorghum plus Cleistachne sorghoides together with those from o... | 25,122,516 | [
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"The Castle of Remembrance": New insights from a cognitive training programme for autobiographical memory in Alzheimer's disease. | Autobiographical memory deficits are prominent from the early stages of Alzheimer's disease (AD) and result in a loss of personal identity. Nevertheless, standardised methods of autobiographical memory stimulation for the neuropsychological rehabilitation of patients with AD remain underdeveloped. Our aim was to evalua... | 25,122,521 | [
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Preparation of microcrystals in lipidic cubic phase for serial femtosecond crystallography. | We have recently established a procedure for serial femtosecond crystallography (SFX) in lipidic cubic phase (LCP) for protein structure determination at X-ray free-electron lasers (XFELs). LCP-SFX uses the gel-like LCP as a matrix for growth and delivery of membrane protein microcrystals for crystallographic data coll... | 25,122,522 | [
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Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite-like aggregates. | This protocol describes a primary neuronal model of formation of α-synuclein (α-syn) aggregates that recapitulate features of the Lewy bodies and Lewy neurites found in Parkinson's disease brains and other synucleinopathies. This model allows investigation of aggregate formation, their impact on neuron function, and de... | 25,122,523 | [
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Comb-push ultrasound shear elastography (CUSE) for evaluation of thyroid nodules: preliminary in vivo results. | In clinical practice, an overwhelming majority of biopsied thyroid nodules are benign. Therefore, there is a need for a complementary and noninvasive imaging tool to provide clinically relevant diagnostic information about thyroid nodules to reduce the rate of unnecessary biopsies. The goal of this study was to evaluat... | 25,122,532 | [
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Italy between drinking culture and control policies for alcoholic beverages. | This paper focuses on whether the on-going dramatic decrease in alcohol consumption in Italy, especially of wine, during 1961-2008, was associated with which parallel sociodemographic and economic changes and with alcohol control policies. The study, using both time series (TS) and artificial neural network (ANN)-based... | 25,122,545 | [
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DEB: definite error bounded tangent estimator for digital curves. | We propose a simple and fast method for tangent estimation of digital curves. This geometric-based method uses a small local region for tangent estimation and has a definite upper bound error for continuous as well as digital conics, i.e., circles, ellipses, parabolas, and hyperbolas. Explicit expressions of the upper ... | 25,122,569 | [
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VSI: a visual saliency-induced index for perceptual image quality assessment. | Perceptual image quality assessment (IQA) aims to use computational models to measure the image quality in consistent with subjective evaluations. Visual saliency (VS) has been widely studied by psychologists, neurobiologists, and computer scientists during the last decade to investigate, which areas of an image will a... | 25,122,572 | [
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0.6505286,
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Intratympanic steroid injection for Bell's palsy: preliminary randomized controlled study. | To investigate adjuvant effect and safety of intratympanic steroid for the treatment of Bell's palsy. Prospective, investigator blinded, randomized study. Tertiary referral center. Patients who received treatment for Bell's palsy from December 2007 to March 2011 were randomly divided into two groups. The control group ... | 25,122,597 | [
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Long-term results of 185 consecutive osseointegrated hearing device implantations: a comparison among children, adults, and elderly. | To determine the occurrence and type of perioperative and postoperative complications in patients implanted with an osseointegrated hearing device (OHD) (also known as BAHA/BAHS) and compare results in children, adults, and elderly and for different surgical techniques. Retrospective case file review. Tertiary referral... | 25,122,598 | [
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Sensorimotor adaptation: multiple forms of plasticity in motor circuits. | One of the most striking properties of the adult central nervous system is its ability to undergo changes in function and/or structure. In mammals, learning is a major inducer of adaptive plasticity. Sensorimotor adaptation is a type of procedural--motor--learning that allows maintaining accurate movements in the prese... | 25,122,611 | [
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Male smoker and non-smoker responses to television advertisements on the harms of secondhand smoke in China, India and Russia. | Mass media campaigns can play an important role in strengthening support for smoke-free policies and reducing exposure to secondhand smoke (SHS). Identifying anti-SHS advertisements that are effective in diverse cultural contexts may allow for resource sharing in low- and middle-income countries. A convenience sample o... | 25,122,618 | [
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Strategies to Promote Cultural Competence in Distance Education. | Cultural competence is a mainstay in health care and nursing education. With the expansion in the number of distance-based nursing programs across the country, innovative teaching methods for distance learning faculty are required to instill cultural competence in students. Faculty must be deliberate when planning dist... | 25,122,626 | [
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Stability study of carboplatin infusion solutions in 0.9% sodium chloride in polyvinyl chloride bags. | Carboplatin is a platinum-containing compound with efficacy against various malignancies. The physico-chemical stability of carboplatin in dextrose 5% water (D5W) has been thoroughly studied; however, there is a paucity of stability data in clinically relevant 0.9% sodium chloride infusion solutions. The manufacturer's... | 25,122,633 | [
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Glycine stimulates protein synthesis and inhibits oxidative stress in pig small intestinal epithelial cells. | Glycine has recently been classified as a nutritionally essential amino acid for maximal growth in young pigs. Currently, little is known about the metabolism or function of glycine in the neonatal intestine. This work was conducted to test the hypothesis that glycine has a protective effect against oxidative stress in... | 25,122,646 | [
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Synergic prodegradative activity of Bicalutamide and trehalose on the mutant androgen receptor responsible for spinal and bulbar muscular atrophy. | Spinal and bulbar muscular atrophy (SBMA) is an X-linked motoneuron disease due to a CAG triplet-repeat expansion in the androgen receptor (AR) gene, which is translated into an elongated polyglutamine (polyQ) tract in AR protein (ARpolyQ). ARpolyQ toxicity is activated by the AR ligand testosterone (or dihydrotestoste... | 25,122,660 | [
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Association of lower extremity performance with cardiovascular and all-cause mortality in patients with peripheral artery disease: a systematic review and meta-analysis. | Peripheral artery disease (PAD) is associated with impaired mobility and a high rate of mortality. The aim of this systematic review was to investigate whether reduced lower extremity performance was associated with an increased incidence of cardiovascular and all-cause mortality in people with PAD. A systematic search... | 25,122,666 | [
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Arginine starvation-associated atypical cellular death involves mitochondrial dysfunction, nuclear DNA leakage, and chromatin autophagy. | Autophagy is the principal catabolic prosurvival pathway during nutritional starvation. However, excessive autophagy could be cytotoxic, contributing to cell death, but its mechanism remains elusive. Arginine starvation has emerged as a potential therapy for several types of cancers, owing to their tumor-selective defi... | 25,122,679 | [
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Type of homogenization and fat loss during continuous infusion of human milk. | Substantial fat loss may occur during continuous feeding of human milk (HM). A decrease of fat loss has been described following homogenization. Well-established methods of homogenization of HM for routine use in the neonatal intensive care unit (NICU) would be desirable. We compared the loss of fat based on the use of... | 25,122,692 | [
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Predictive impact on medium-term mortality of hematological parameters in Acute Coronary Syndromes: added value on top of GRACE risk score. | Red Cell Distribution Width (RDW) prognostic value in patients with Acute Coronary Syndrome (ACS) has been well validated whereas that of Platelet Distribution Width (PDW) is less well known. Investigate the incremental prognostic value, on top of GRACE risk score, of a new variable resulting from the combination of RD... | 25,122,727 | [
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Monte Carlo non-local means: random sampling for large-scale image filtering. | We propose a randomized version of the nonlocal means (NLM) algorithm for large-scale image filtering. The new algorithm, called Monte Carlo nonlocal means (MCNLM), speeds up the classical NLM by computing a small subset of image patch distances, which are randomly selected according to a designed sampling pattern. We ... | 25,122,743 | [
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Probing the elastic limit of DNA bending. | Sharp bending of double-stranded DNA (dsDNA) plays an essential role in genome structure and function. However, the elastic limit of dsDNA bending remains controversial. Here, we measured the opening rates of small dsDNA loops with contour lengths ranging between 40 and 200 bp using single-molecule Fluorescence Resonan... | 25,122,748 | [
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Inhibition of neuronal cell mitochondrial complex I with rotenone increases lipid β-oxidation, supporting acetyl-coenzyme A levels. | Rotenone is a naturally occurring mitochondrial complex I inhibitor with a known association with parkinsonian phenotypes in both human populations and rodent models. Despite these findings, a clear mechanistic link between rotenone exposure and neuronal damage remains to be determined. Here, we report alterations to l... | 25,122,772 | [
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Type I interferon protects mice from fatal neurotropic infection with Langat virus by systemic and local antiviral responses. | Vector-borne flaviviruses, such as tick-borne encephalitis virus (TBEV), West Nile virus, and dengue virus, cause millions of infections in humans. TBEV causes a broad range of pathological symptoms, ranging from meningitis to severe encephalitis or even hemorrhagic fever, with high mortality. Despite the availability ... | 25,122,777 | [
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Modulation of hepatitis C virus genome replication by glycosphingolipids and four-phosphate adaptor protein 2. | Hepatitis C virus (HCV) assembles its replication complex on cytosolic membrane vesicles often clustered in a membranous web (MW). During infection, HCV NS5A protein activates PI4KIIIα enzyme, causing massive production and redistribution of phosphatidylinositol 4-phosphate (PI4P) lipid to the replication complex. Howe... | 25,122,779 | [
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Emergence of broadly neutralizing antibodies and viral coevolution in two subjects during the early stages of infection with human immunodeficiency virus type 1. | Delineating the key early events that lead to the development of broadly neutralizing anti-HIV-1 antibodies during natural infection may help guide the development of immunogens and vaccine regimens to prevent HIV-1 infection. In this study, we monitored two HIV-1-positive subjects, VC20013 and VC10014, over the course... | 25,122,781 | [
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The N terminus of the influenza B virus nucleoprotein is essential for virus viability, nuclear localization, and optimal transcription and replication of the viral genome. | The nucleoprotein (NP) of influenza viruses is a multifunctional protein with essential roles throughout viral replication. Despite influenza A and B viruses belonging to separate genera of the Orthomyxoviridae family, their NP proteins share a relatively high level of sequence conservation. However, NP of influenza B ... | 25,122,787 | [
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The VP4 peptide of hepatitis A virus ruptures membranes through formation of discrete pores. | Membrane-active peptides, components of capsid structural proteins, assist viruses in overcoming the host membrane barrier in the initial stages of infection. Several such peptides have been identified, and their roles in membrane fusion or disruption have been characterized through biophysical studies. In several memb... | 25,122,794 | [
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Global asymptotic stabilization using adaptive fuzzy PD control. | It is well-known that standard adaptive fuzzy control (AFC) can only guarantee uniformly ultimately bounded stability due to inherent fuzzy approximation errors (FAEs). This paper proves that standard AFC with proportional-derivative (PD) control can guarantee global asymptotic stabilization even in the presence of FAE... | 25,122,847 | [
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Evaluation of the nanosphere Verigene BC-GN assay for direct identification of gram-negative bacilli and antibiotic resistance markers from positive blood cultures and potential impact for more-rapid antibiotic interventions. | The Verigene BC-GN assay correctly identified all 51 Gram-negative bacilli (GNB) from positive blood cultures and all 14 carbapenemase enzymes tested. The assay gave organism identification (ID) results an average of 24 h faster compared to conventional identifications. Medical management could have been modified for 3... | 25,122,857 | [
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Two cases of bacteriemia caused by nontoxigenic, non-O1, non-O139 Vibrio cholerae isolates in Ho Chi Minh City, Vietnam. | The toxigenic bacterium Vibrio cholerae belonging to the O1 and O139 serogroups is commonly associated with epidemic diarrhea in tropical settings; other diseases caused by this environmental pathogen are seldom identified. Here we report two unassociated cases of nonfatal, nontoxigenic V. cholerae non-O1, non-O139 bac... | 25,122,858 | [
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Chemogenetic silencing of neurons in retrosplenial cortex disrupts sensory preconditioning. | An essential aspect of episodic memory is the formation of associations between neutral sensory cues in the environment. In light of recent evidence that this critical aspect of learning does not require the hippocampus, we tested the involvement of the retrosplenial cortex (RSC) in this process using a chemogenetic ap... | 25,122,898 | [
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The essential role of primate orbitofrontal cortex in conflict-induced executive control adjustment. | Conflict in information processing evokes trial-by-trial behavioral modulations. Influential models suggest that adaptive tuning of executive control, mediated by mid-dorsal lateral prefrontal cortex (mdlPFC) and anterior cingulate cortex (ACC), underlies these modulations. However, mdlPFC and ACC are parts of distribu... | 25,122,901 | [
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Concentrations of mobile source air pollutants in urban microenvironments. | Human exposures to criteria and hazardous air pollutants (HAPs) in urban areas vary greatly due to temporal-spatial variations in emissions, changing meteorology, varying proximity to sources, as well as due to building, vehicle, and other environmental characteristics that influence the amounts of ambient pollutants t... | 25,122,949 | [
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Role of sodium ions in the vitrification process: glass matrix modification, slag structure depolymerization, and influence of metal immobilization. | This study investigates the role of Na ions, a common flux, in the vitrification process. Artificial glass systems composed of Al2O3, CaO, and SiO2 with various Na concentrations were melted at 1450 degrees C. The specimens were cooled by air cooling and water quenching and the metal mobility was evaluated using a sequ... | 25,122,951 | [
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Clinical supervision in the 21st century: revisiting pressing needs and impressing possibilities. | What are some of the most pressing needs currently confronting clinical supervision? In this paper, I give attention to that question. Drawing on two 1990 reviews for comparative purposes, I examine where supervision is now relative to four areas: (a) supervision training and practice; (b) measurement; (c) difference a... | 25,122,988 | [
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Is starting with the feet out of the water faster in backstroke swimming? | This study aimed to determine if starting with the feet above the water (FAW) in male backstroke swimming resulted in faster start times (15-m time) than when the feet were underwater (FUW). It was hypothesised that setting higher on the wall would generate increased horizontal force and velocity, resulting in quicker ... | 25,123,000 | [
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Patency of vascular accesses for Thai hemodialysis patients. | Vascular access for hemodialysis is the mode of renal replacement therapy for chronic renal failure patients. The present study reports patency rates of arteriovenous fistula (AVF) and graft (AVG). Between July 2008 and June 2011, 336 vascular accesses were performed in 293 patients in Department of Surgery, Faculty of... | 25,123,011 | [
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A specialized post anaesthetic care unit improves fast-track management in cardiac surgery: a prospective randomized trial. | Fast-track treatment in cardiac surgery has become the global standard of care. We compared the efficacy and safety of a specialised post-anaesthetic care unit (PACU) to a conventional intensive care unit (ICU) in achieving defined fast-track end-points in adult patients after elective cardiac surgery. In a prospective... | 25,123,092 | [
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An eight-year epidemiologic study based on baculovirus-expressed type-specific spike proteins for the differentiation of type I and II feline coronavirus infections. | Feline infectious peritonitis (FIP) is a fatal disease caused by feline coronavirus (FCoV). FCoVs are divided into two serotypes with markedly different infection rates among cat populations around the world. A baculovirus-expressed type-specific domain of the spike proteins of FCoV was used to survey the infection of ... | 25,123,112 | [
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Predictors of long-term effect from education and exercise in patients with knee and hip pain. | Education and exercise are poorly implemented in osteoarthritis care. The purpose of the present study was to identify predictors of effectiveness at one year from education and exercise in patients with knee or hip pain in clinical practice. Good Life with Arthritis in Denmark is an implementation initiative consistin... | 25,123,117 | [
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Improvement in health-related quality of life following Roux-en-Y gastric bypass. | This study explored whether health-related quality of life (HRQOL) changes following Roux-en-Y gastric bypass surgery were associated with identifiable socio-demographic or clinical characteristics, and it examined the impact on health outcomes of changes in the Danish criteria for bariatric surgery. Participants (n = ... | 25,123,120 | [
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The biomechanics of biodegradable versus titanium interference screw fixation for anterior cruciate ligament augmentation and reconstruction. | The ligament augmentation and reconstruction system (LARS) is one of the options available for anterior cruciate ligament (ACL) reconstruction. To date, however, there are no published data regarding the biomechanical properties of LARS fixation for ACL reconstruction. The aim of this study was to investigate the biome... | 25,123,129 | [
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Overexpression of miR-146a in basal-like breast cancer cells confers enhanced tumorigenic potential in association with altered p53 status. | The tumor suppressor p53 is the most frequently mutated gene in human cancers, mutated in 25-30% of breast cancers. However, mutation rates differ according to breast cancer subtype, being more prevalent in aggressive estrogen receptor-negative tumors and basal-like and HER2-amplified subtypes. This heterogeneity sugge... | 25,123,132 | [
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Defective RAGE activity in embryonal rhabdomyosarcoma cells results in high PAX7 levels that sustain migration and invasiveness. | Rhabdomyosarcoma is a muscle-derived malignant tumor mainly affecting children. The most frequent variant, embryonal rhabdomyosarcoma (ERMS) is characterized by overexpression of the transcription factor, PAX7 which prevents ERMS cells from exiting the cell cycle and terminally differentiating. However, a role for PAX7... | 25,123,133 | [
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[Viral safety of biological medicinal products]. | Viral safety of blood donations, plasma products, viral vaccines and gene therapy medicinal products, biotechnical-derived products and tissue and cell therapy products is a particular challenge. These products are manufactured using a variety of human or animal-derived starting materials and reagents; therefore, exten... | 25,123,140 | [
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Elevated APOBEC3B correlates with poor outcomes for estrogen-receptor-positive breast cancers. | Recent observations connected DNA cytosine deaminase APOBEC3B to the genetic evolution of breast cancer. We addressed whether APOBEC3B is associated with breast cancer clinical outcomes. APOBEC3B messenger RNA (mRNA) levels were related in 1,491 primary breast cancers to disease-free (DFS), metastasis-free (MFS), and o... | 25,123,150 | [
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Immunohistochemical panel for the diagnosis of Hirschsprung's disease using antibodies to MAP2, calretinin, GLUT1 and S100. | The diagnosis of Hirschsprung's disease is currently based on the identification of aganglionosis and the presence of an increase in acetylcholinesterase-positive hypertrophic nerve fibres in the large bowel submucosa. However, acetylcholinesterase staining is laborious and requires a skilled technician. The aim of thi... | 25,123,159 | [
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Association between gestational age at birth, antenatal corticosteroids, and outcomes at 5 years: multiple courses of antenatal corticosteroids for preterm birth study at 5 years of age (MACS-5). | The Multiple Courses of Antenatal Corticosteroids for Preterm Birth Study (MACS) showed no benefit in the reduction of major neonatal mortality/morbidity or neurodevelopment at 2 and 5 years of age. Using the data from the randomized controlled trial and its follow-up, the aim of this study was to evaluate the associat... | 25,123,162 | [
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The pathologic correlation between liver and portal vein invasion in perihilar cholangiocarcinoma: evaluating the oncologic rationale for the American Joint Committee on Cancer definitions of T2 and T3 tumors. | The American Joint Committee on Cancer (AJCC) has recommended that cancers with liver involvement be graded T2b and those with portal vein involvement be graded T3, although the value of staging as prognostic factors remains unclear. We evaluated the current definition of the T2/3 tumors for perihilar cholangiocarcinom... | 25,123,177 | [
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Tryptophan as a probe to study the anticancer mechanism of action and specificity of α-helical anticancer peptides. | In the present study, a single tryptophan, as a fluorescence probe, was shifted from the N-terminus to the middle and to the C-terminus of a 26-residue α-helical anticancer peptide sequence to study the mechanism of action and specificity. The hydrophobicity of peptides, as well as peptide helicity and self-associating... | 25,123,187 | [
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Acute kidney injury after snakebite accident treated in a Brazilian tertiary care centre. | Acute kidney injury (AKI) is one of the main causes of morbidity and mortality in cases of envenomation by venomous snakes. The present study was carried out to investigate the clinical and laboratory manifestations in accidents with venomous snakes and the risk factors associated with AKI in these accidents. A retrosp... | 25,123,203 | [
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Effects of childhood abuse on adult obesity: a systematic review and meta-analysis. | Controversy exists surrounding the role of childhood abuse in obesity development. This is a meta-analysis of observational studies on the role of childhood abuse in adult obesity. Systematic searches of PubMed, PsycInfo, Medline and CINAHL resulted in 23 cohort studies (4 prospective, 19 retrospective) with n=112,708 ... | 25,123,205 | [
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Low levels of low-density lipoprotein-C associated with proprotein convertase subtilisin kexin 9 inhibition do not increase the risk of hemorrhagic transformation. | Low levels of low-density lipoprotein-cholesterol (LDL-C) are suspected to be associated with a risk of hemorrhagic transformation after ischemic stroke. We assessed the risk of hemorrhagic transformation after cerebral ischemia/reperfusion in mice with low levels of LDL-C resulting from proprotein convertase subtilisi... | 25,123,222 | [
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A pilot prospective study to evaluate whether the bladder morphology in cystography and/or urodynamic may help predict the response to botulinum toxin a injection in neurogenic bladder refractory to anticholinergics. | We have observed different clinical responses to botulinum toxin A (BTX-A) in patients who had similar urodynamic parameters before the procedure. Furthermore, some bladders evaluated by cystography and cystoscopy during the procedure had different characteristics that could influence the outcome of the treatment. The ... | 25,123,234 | [
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Vitamin E supplementation in chemical colorectal carcinogenesis: a two-edged knife. | This work investigated the effects of Vitamin E (VE) on aberrant crypt foci (ACF) incidence, oxidative stress parameters (serum and hepatic VE concentration, and homocysteine, glutathione (GSH), and malondialdehyde (MDA) levels), and expression of both cyclooxygenase-2 (COX2) and proliferating cellular nuclear antigen ... | 25,123,248 | [
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A significant inhibitory effect on advanced glycation end product formation by catechin as the major metabolite of lotus seedpod oligomeric procyanidins. | Several lines of evidence suggested that B-type procyanidin oligomers from lotus seedpod (LSOPC) may effectively modulate the formation of advanced glycation end products (AGEs). In vivo, LSOPC is metabolized by intestinal flora to become various kinds of phenolic compounds that possess potent antioxidant activities. H... | 25,123,249 | [
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Matrix metalloproteinase-7 mRNA and protein expression in gastric carcinoma: a meta-analysis. | Messenger RNA (mRNA) acts as template for protein synthesis. The matrix metalloproteinase-7 (MMP-7) protein and its mRNA expression have been suggested to be involved in the development of various diseases and cancers. We aimed to study associations between the MMP-7 protein and mRNA expression in gastric carcinoma (GC... | 25,123,263 | [
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Transcriptional and epigenetic networks of helper T and innate lymphoid cells. | The discovery of the specification of CD4(+) helper T cells to discrete effector 'lineages' represented a watershed event in conceptualizing mechanisms of host defense and immunoregulation. However, our appreciation for the actual complexity of helper T-cell subsets continues unabated. Just as the Sami language of Scan... | 25,123,275 | [
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Orchestration of plasma cell differentiation by Bach2 and its gene regulatory network. | Bach2 is a basic region-leucine zipper (bZip) transcription factor that forms heterodimers with small Maf oncoproteins and binds to target genes, thus repressing their expression. Bach2 is required for class switch recombination (CSR) and somatic hypermutation (SHM) of immunoglobulin genes in activated B cells. Bach2 r... | 25,123,280 | [
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A search for the most accurate formula for sonographic weight estimation by fetal sex - a retrospective cohort study. | The aim of this study was to assess the effect of fetal sex on the accuracy of multiple formulas for sonographic estimation fetal weight (SEFW). The cohort included all singleton live births recorded at a single medical center from January 2004 to September 2011. The accuracy of SEFW was compared between male and femal... | 25,123,290 | [
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A multicentre randomized trial of the treatment of patients with pemphigus vulgaris with infliximab and prednisone compared with prednisone alone. | Pemphigus vulgaris (PV) is a blistering disease and tumour necrosis factor-α has a role in its pathogenesis. To evaluate the safety of infliximab (IFX) with prednisone compared with prednisone alone in the treatment of PV. In addition, treatment response was assessed and mechanistic studies were performed. Subjects wit... | 25,123,295 | [
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... |
Separate microcircuit modules of distinct v2a interneurons and motoneurons control the speed of locomotion. | Spinal circuits generate locomotion with variable speed as circumstances demand. These circuits have been assumed to convey equal and uniform excitation to all motoneurons whose input resistance dictates their activation sequence. However, the precise connectivity pattern between excitatory premotor circuits and the di... | 25,123,308 | [
0.1605068,
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0.1070181,
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0.09282944,
0.1566707,
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-0.1801882... |
Amygdala-dependent fear memory consolidation via miR-34a and Notch signaling. | Using an array-based approach after auditory fear conditioning and microRNA (miRNA) sponge-mediated inhibition, we identified a role for miR-34a within the basolateral amygdala (BLA) in fear memory consolidation. Luciferase assays and bioinformatics suggested the Notch pathway as a target of miR-34a. mRNA and protein l... | 25,123,309 | [
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0.3351148,
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... |
Network structure within the cerebellar input layer enables lossless sparse encoding. | The synaptic connectivity within neuronal networks is thought to determine the information processing they perform, yet network structure-function relationships remain poorly understood. By combining quantitative anatomy of the cerebellar input layer and information theoretic analysis of network models, we investigated... | 25,123,311 | [
0.1887104,
0.0773512,
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0.426039,
0.372702,
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The Drosophila IR20a clade of ionotropic receptors are candidate taste and pheromone receptors. | Insects use taste to evaluate food, hosts, and mates. Drosophila has many "orphan" taste neurons that express no known taste receptors. The Ionotropic Receptor (IR) superfamily is best known for its role in olfaction, but virtually nothing is known about a clade of ∼35 members, the IR20a clade. Here, a comprehensive an... | 25,123,314 | [
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0.2483534,
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Increasing the sensitivity of endocervical curettings by performing ThinPrep® Pap on transport container fluid: is diagnostic material going down the drain? | The sensitivity of endocervical curettage (ECC) can be suboptimal because of limited epithelial tissue. The false-negative rate for ECC in patients with cervical intraepithelial neoplasia involving the endocervical canal has been reported to be 45%. ECC samples are transported to pathology in formalin- or saline-filled... | 25,123,326 | [
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0.4641915,
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Clinical evidence and bioinformatics characterization of potential hepatitis C virus resistance pathways for sofosbuvir. | Sofosbuvir (Sovaldi, SOF) is a nucleotide analog prodrug that targets the hepatitis C virus (HCV) nonstructural protein 5B (NS5B) polymerase and inhibits viral replication. High sustained virological response rates are achieved when SOF is used in combination with ribavirin with or without pegylated interferon in subje... | 25,123,381 | [
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0.1518807,
0.09079658,
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0.4863449,
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0.3261204,
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... |
A comparison of airway dimensions, measured by acoustic reflectometry and ultrasound before and after general anaesthesia. | Changes in airway dimensions can occur during general anaesthesia and surgery for a variety of reasons. This study explored factors associated with postoperative changes in airway dimensions. Patient airway volume was measured by acoustic reflectometory and neck muscle diameter by ultrasound echography in the pre- and ... | 25,123,382 | [
0.05821219,
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0.1736749,
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0.3436077,
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0.1520176,
... |
A national study on adherence to a basal cell carcinoma guideline; development of a tool to assess guideline adherence. | Clinical practice guideline implementation may be at variance with actual daily practice, as guideline adherence is a complex process depending on many actors and factors. Feedback regarding adherence is essential to monitor the effect that a guideline has in clinical practice and whether or not the quality of care is ... | 25,123,410 | [
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0.2361142,
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0.3493977,
0.2537377,
0.0568408,
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0.... |
Cytotoxic effects of escin on human castration-resistant prostate cancer cells through the induction of apoptosis and G2/M cell cycle arrest. | To evaluate the in vitro and in vivo effects of escin on human castration-resistant prostate cancer (CRPC) cells, PC-3 and DU-145. The inhibition of cell proliferation and its mechanism were assessed through a cytotoxicity assay, flow cytometry, and Western blot. The in vivo efficacy of escin in CRPC cells was assessed... | 25,123,426 | [
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0.1746061,
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0.3014179,
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0.1795716,
-0.09065466,... |
MiR-7b directly targets DC-STAMP causing suppression of NFATc1 and c-Fos signaling during osteoclast fusion and differentiation. | DC-STAMP is a key regulating molecule of osteoclastogenesis and osteoclast precursor (OCP) fusion. Emerging lines of evidence showed that microRNAs play crucial roles in bone metabolism and osteoclast differentiation, but no microRNA has yet been reported to be directly related to OCPs fusion. Through a microarray, we ... | 25,123,438 | [
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0.5382724,
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0.427204,
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-0.0713906,
0.3614963,
0.1451751,
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0.... |
The free-exploratory paradigm as a model of trait anxiety in female rats: test-retest reliability. | The free-exploratory paradigm has been proposed as a model of trait anxiety and as such has been proven stable over time, which is a sine qua non condition for any model proposing to evaluate a personality trait. However this stability has only been shown for male rats. Considering that anxiety disorders are most preva... | 25,123,445 | [
-0.1353039,
0.1003315,
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0.1328982,
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0.04973787,
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0.002894433,
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-0.08435449,
-0.1586873,
-0.2081618,
0.1287763,... |
The re-organization of functional brain networks in pharmaco-resistant epileptic patients who respond to VNS. | Vagal nerve stimulation (VNS) is a therapeutic add-on treatment for patients with pharmaco-resistant epilepsy. The mechanism of action is still largely unknown. Previous studies have shown that brain network topology during the inter-ictal period in epileptic patients deviates from normal configuration. In the present ... | 25,123,446 | [
0.02041605,
0.07190456,
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0.2556403,
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0.4355494,
0.02628561,
0.1820038,
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0.2697386,
-0.1119951... |
QoS-aware health monitoring system using cloud-based WBANs. | Wireless Body Area Networks (WBANs) are amongst the best options for remote health monitoring. However, as standalone systems WBANs have many limitations due to the large amount of processed data, mobility of monitored users, and the network coverage area. Integrating WBANs with cloud computing provides effective solut... | 25,123,456 | [
-0.1570139,
0.3589858,
0.009649991,
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0.2174211,
-0.4264272,
0.005434277,
0.07712266,
-0.207802... |
Time- and computation-efficient calibration of MEMS 3D accelerometers and gyroscopes. | We propose calibration methods for microelectromechanical system (MEMS) 3D accelerometers and gyroscopes that are efficient in terms of time and computational complexity. The calibration process for both sensors is simple, does not require additional expensive equipment, and can be performed in the field before or betw... | 25,123,469 | [
-0.243055,
0.216674,
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0.1854999,
0.1199695,
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0.1959643,
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0.1787949,
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0.09690943,
0.4358244,
-0.1381978,
-0.1028278,
0.18... |
Laparoscopic common bile duct exploration. | Laparoscopic common bile duct exploration (LCBDE) is a safe and effective single-stage treatment for choledocholithiasis in the elective setting. The outcomes after LCBDE in the emergency setting are unknown. The aim of this study was to compare the outcomes following elective and emergency LCBDE for choledocholithiasi... | 25,123,479 | [
0.07789624,
-0.0846727,
-0.2245462,
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-0.4402258,
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0.570718,
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0.2005289,
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0.07990218,
0.3809757,
-0.2244162... |
Structural biology. Crystal structure of a CRISPR RNA-guided surveillance complex bound to a ssDNA target. | In prokaryotes, RNA derived from type I and type III CRISPR loci direct large ribonucleoprotein complexes to destroy invading bacteriophage and plasmids. In Escherichia coli, this 405-kilodalton complex is called Cascade. We report the crystal structure of Cascade bound to a single-stranded DNA (ssDNA) target at a reso... | 25,123,481 | [
-0.2102685,
0.1733039,
-0.1319018,
-0.2402815,
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-0.1082242,
-0.3285533,
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0.4112042,
0.04988843,
-0.2693884,
... |
The effect of hazelnut roasted skin from different cultivars on the quality attributes, polyphenol content and texture of fresh egg pasta. | Hazelnut skin is the perisperm of the hazelnut kernel. It is separated from the kernel during the roasting process and is normally discarded. Recent studies have reported that hazelnut skin is a rich source of dietary fibre as well as of natural antioxidants owing to the presence of phenolic compounds. The aim of this ... | 25,123,494 | [
0.3352832,
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0.05636087,
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0.06416811,
0.07600106,
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0.21649,
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0.1884517,
0.3235011,
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... |
Hydrogen sulfide is essential for Schwann cell responses to peripheral nerve injury. | Hydrogen sulfide (H2 S) functions as a physiological gas transmitter in both normal and pathophysiological cellular events. H2 S is produced from substances by three enzymes: cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (MST). In human tissues, these enzymes are ... | 25,123,509 | [
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0.06047324,
0.1620592,
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0.2559484,
-0.1695424,
... |
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