title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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N-alkynyl derivatives of 5-fluorouracil: susceptibility to palladium-mediated dealkylation and toxigenicity in cancer cell culture. | Palladium-activated prodrug therapy is an experimental therapeutic approach that relies on the unique chemical properties and biocompatibility of heterogeneous palladium catalysis to enable the spatially-controlled in vivo conversion of a biochemically-stable prodrug into its active form. This strategy, which would all... | 25,121,087 | [
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A synchronous-asynchronous particle swarm optimisation algorithm. | In the original particle swarm optimisation (PSO) algorithm, the particles' velocities and positions are updated after the whole swarm performance is evaluated. This algorithm is also known as synchronous PSO (S-PSO). The strength of this update method is in the exploitation of the information. Asynchronous update PSO ... | 25,121,109 | [
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Locked mouths: Tooth loss in a women's prison in northeastern Brazil. | Prisoners, in general, exhibit unsatisfactory oral conditions, especially with regard to the large number of missing teeth and with untreated caries. The aim of this study was to assess tooth loss, use of and need for prosthetic rehabilitation, and use of dental services among inmates. A cross-sectional study involving... | 25,121,127 | [
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A note on parametric surfaces in Minkowski 3-space. | With the help of the Frenet frame of a given pseudo null curve, a family of parametric surfaces is expressed as a linear combination of this frame. The necessary and sufficient conditions are examined for that curve to be an isoparametric and asymptotic on the parametric surface. It is shown that there is not any cylin... | 25,121,129 | [
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On the open problem related to rank equalities for the sum of finitely many idempotent matrices and its applications. | Tian and Styan have shown many rank equalities for the sum of two and three idempotent matrices and pointed out that rank equalities for the sum P₁ + ⋯+P k with P₁,…, P k be idempotent (k > 3) are still open. In this paper, by using block Gaussian elimination, we obtained rank equalities for the sum of finitely many... | 25,121,133 | [
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Generalized equilibrium problem with mixed relaxed monotonicity. | We extend the concept of relaxed α-monotonicity to mixed relaxed α-β-monotonicity. The concept of mixed relaxed α-β-monotonicity is more general than many existing concepts of monotonicities. Finally, we apply this concept and well known KKM-theory to obtain the solution of generalized equilibrium problem. | 25,121,137 | [
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Antibiotic therapy for acute appendicitis in adults. Fewer immediate complications than with surgery, but more subsequent failures. | Appendectomy is the standard treatment for acute appendicitis. Since the 1990s, antibiotic therapy has sometimes been proposed as an alternative to immediate appendectomy. How effective are antibiotics in adults with uncomplicated acute appendicitis, and what is the risk of complications? To answer these questions, we ... | 25,121,154 | [
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Baseline extracellular potassium level as an indicator of the rate of increase of the same on further storage in CPDA-1 whole blood units: a potential approach to complement FIFO system for prioritisation of blood bags for release from blood-banks. | Potassium levels in stored blood bags increases as they age. Hyperkalemia in transfused blood has undesirable cardiac effects. Within a 19-month period, baseline and weekly samples from 15 CPDA-1 whole blood bags were collected till 28 days of storage and analysed for potassium, sodium, uric acid, albumin and whole blo... | 25,121,159 | [
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Job satisfaction, organisation commitment and retention in the public workforce: a survey among pharmacists in Malaysia. | The aims of the study were to assess job satisfaction and organisational commitment among pharmacists working in the public sector and its influence on their likelihood to stay within the public workforce. A cross-sectional survey was conducted among all fully registered pharmacists (FRPs) in the northern states of Mal... | 25,121,161 | [
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Objective and subjective socioeconomic status and health symptoms in patients following hematopoietic stem cell transplantation. | Recent research indicates that subjective socioeconomic status (SES) – the perception of one's own SES compared with other people – is an important predictor of cancer-related health outcomes. Subjective SES may function as a psychosocial mechanism by which objective SES affects health, well-being, and, more broadly, q... | 25,121,168 | [
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NMR, calorimetry, and computational studies of aqueous solutions of N-methyl-2-pyrrolidone. | N-Methyl-2-pyrrolidone (NMP) is a solvent with applications in different industrial fields. Although largely employed in aqueous mixtures, little is known on the structural and dynamic properties of this system. In order to improve the knowledge on NMP aqueous solutions, useful to the development of their applications,... | 25,121,346 | [
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Outcomes of surgical site infections in orthopedic trauma surgeries in a tertiary care centre in India. | Surgical site infections (SSIs) still cause significant morbidity and mortality despite advances in trauma care. We have studied in this paper the rate of SSIs, their outcomes in patients undergoing interventions for trauma and SSI trends in developing countries. A 16-month study (May, 2011- August, 2012) was carried o... | 25,121,363 | [
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Lower levels of serum high-density lipoprotein cholesterol are associated with a worse Duke treadmill score in men but not in women. | High-density lipoprotein cholesterol (HDL-C) levels are inversely related to the atherosclerotic burden and are higher in women than in men. We aimed to investigate the sex-specific relationship between serum HDL-C levels and the Duke treadmill score (DTS) in this study. A total of 111 patients (59 men, 42 women) with ... | 25,121,364 | [
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ProSeal Laryngeal Mask Airway Attenuates Systemic and Cerebral Hemodynamic Response During Awakening of Neurosurgical Patients: A Randomized Clinical Trial. | Extubation and emergence from anesthesia may lead to systemic and cerebral hemodynamic changes that endanger neurosurgical patients. We aimed to compare systemic and cerebral hemodynamic variables and cough incidence in neurosurgery patients emerging from general anesthesia with the standard procedure (endotracheal tub... | 25,121,397 | [
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Custom-modified three-dimensional periodic microstructures by pattern-integrated interference lithography. | By combining interference lithography and projection photolithography concurrently, pattern-integrated interference lithography (PIIL) enables the wafer-scale, rapid, and single-exposure fabrication of multidimensional periodic microstructures that integrate arbitrary functional elements. To date, two-dimensional PIIL ... | 25,121,439 | [
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Nonparaxial propagation and focusing properties of azimuthal-variant vector fields diffracted by an annular aperture. | Based on the vectorial Rayleigh-Sommerfeld integrals, the analytical expressions for azimuthal-variant vector fields diffracted by an annular aperture are presented. This helps us to investigate the propagation behaviors and the focusing properties of apertured azimuthal-variant vector fields under nonparaxial and para... | 25,121,455 | [
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Copper clusters as novel fluorescent probes for the detection and photocatalytic elimination of lead ions. | A new homogeneous assay for a fast, selective and sensitive detection and elimination of lead ions has been developed using copper clusters as novel fluorescent probes in aqueous solutions. At the same time, their elimination is achieved using the efficient photocatalytic activity of such clusters. Both effects are exp... | 25,121,465 | [
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Contact tracing investigation after professional exposure to tuberculosis in a Swiss hospital using both tuberculin skin test and IGRA. | A 950 bed teaching hospital in Switzerland. To describe the result of a contact investigation among health care workers (HCW) and patients after exposure to a physician with smear-positive pulmonary tuberculosis in a hospital setting using standard tuberculin skin tests (TST) and Interferon-gamma release assay (IGRA). ... | 25,121,477 | [
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Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol. | Performance assessment of instruments devised for clinical applications is of key importance for validation and quality assurance. Two new protocols were developed and applied to facilitate the design and optimization of instruments for time-domain optical brain imaging within the European project nEUROPt. Here, we pre... | 25,121,479 | [
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Compromised dynamic cerebral autoregulation in patients with a right-to-left shunt: a potential mechanism of migraine and cryptogenic stroke. | The relationship between right-to-left shunts (RLS) and migraine and cryptogenic stroke is not well understood. In this study, we investigated whether RLS are associated with impairment of dynamic cerebral autoregulation (dCA), which may play a role in migraine and cryptogenic stroke. Sixty-six migraineurs were enrolle... | 25,121,485 | [
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Altered resting-state FMRI signals in acute stroke patients with ischemic penumbra. | Identifying the ischemic penumbra in acute stroke subjects is important for the clinical decision making process. The aim of this study was to use resting-state functional magnetic resonance singal (fMRI) to investigate the change in the amplitude of low-frequency fluctuations (ALFF) of these subjects in three differen... | 25,121,486 | [
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Efficacy and safety of rituximab in children with difficult-to-treat nephrotic syndrome. | Rituximab has emerged as an important medication for patients with steroid-dependent or steroid-resistant nephrotic syndrome. We report the efficacy and safety of therapy with intravenous rituximab, administered once weekly for 2-4 doses, in 193 patients (mean age 10.9, range 2.2-18.7 years) with difficult-to-treat ste... | 25,121,488 | [
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Distribution of schistosomiasis and soil transmitted helminthiasis in Zimbabwe: towards a national plan of action for control and elimination. | Schistosomiasis and STH are among the list of neglected tropical diseases considered for control by the WHO. Although both diseases are endemic in Zimbabwe, no nationwide control interventions have been implemented. For this reason in 2009 the Zimbabwe Ministry of Health and Child Care included the two diseases in the ... | 25,121,489 | [
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Hyperglycemia and blood pressure treatment goal: a cross sectional survey of 18350 patients with type 2 diabetes in 77 tertiary hospitals in China. | To investigate the association of hyperglycemia with blood pressure control goal in the patients with type 2 diabetes (T2D) cared by tertiary hospitals in China. A cross sectional survey of 29442 patients was conducted in 77 tertiary hospitals in 4 major cities in China in 2011 and 18350 of them without known hypertens... | 25,121,493 | [
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Phosphorylation of a central clock transcription factor is required for thermal but not photic entrainment. | Transcriptional/translational feedback loops drive daily cycles of expression in clock genes and clock-controlled genes, which ultimately underlie many of the overt circadian rhythms manifested by organisms. Moreover, phosphorylation of clock proteins plays crucial roles in the temporal regulation of clock protein acti... | 25,121,504 | [
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Changes in corneal deformation parameters after lenticule creation and extraction during small incision lenticule extraction (SMILE) procedure. | To investigate the effects of lenticule creation and subsequent corneal lenticule extraction on corneal deformation parameters during small incision lenticule extraction (SMILE) procedure. In this prospective study, 18 eyes of 10 patients (27.90 ± 7.11 years, -5.64 ± 2.45 diopters) scheduled for SMILE procedure were en... | 25,121,508 | [
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Comparing interferon-gamma release assays to tuberculin skin test in Thai children with tuberculosis exposure. | Data on the performance of interferon-gamma release assays (IGRAs), QuantiFERON TB Gold In-tube (QFNGIT) and T-Spot.TB, in diagnosing tuberculosis (TB) are limited in Southeast Asia. This study aims to compare the performances of the two IGRAs and TST in Thai children with recent TB exposure. This multicenter, prospect... | 25,121,513 | [
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Optical phase under deep turbulence conditions. | The Markov approximation for waves in random media specifies that, under strong scintillation conditions, the optical field of unbounded waves has a normal probability distribution with zero mean. Using the coherence function provided by the Markov approximation, we calculate statistics of the phase of the optical fiel... | 25,121,533 | [
-0.1491308,
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0.001025507,
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Plasmonic corrugated cylinder-cone terahertz probe. | The spoof surface plasmon polariton (SPP) effect on the electromagnetic field distribution near the tip of a periodically corrugated metal cylinder-cone probe working at the terahertz regime was studied. We found that radially polarized terahertz radiation could be coupled effectively through a spoof SPP into a surface... | 25,121,543 | [
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0.06740095,
... |
Introducing the concept of anisotropy at different scales for modeling optical turbulence. | In this paper, the concept of anisotropy at different atmospheric turbulence scales is introduced. A power spectrum and its associated structure function with inner and outer scale effects and anisotropy are also shown. The power spectrum includes an effective anisotropic parameter ζ(eff) to describe anisotropy, which ... | 25,121,545 | [
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... |
Photochemical tyrosine oxidation in the structurally well-defined α3Y protein: proton-coupled electron transfer and a long-lived tyrosine radical. | Tyrosine oxidation-reduction involves proton-coupled electron transfer (PCET) and a reactive radical state. These properties are effectively controlled in enzymes that use tyrosine as a high-potential, one-electron redox cofactor. The α3Y model protein contains Y32, which can be reversibly oxidized and reduced in volta... | 25,121,576 | [
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Reduction-sensitive dual functional nanomicelles for improved delivery of paclitaxel. | We have developed a dual-functional nanocarrier composed of a hydrophilic polyethylene glycol (PEG) and a hydrophobic farnesylthiosalicylate (FTS, a nontoxic Ras antagonist), which is effective in delivery of hydrophobic anticancer drug, paclitaxel (PTX). To facilitate the retention of the therapeutic activity of the c... | 25,121,577 | [
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0.04541639,
... |
Loop-Closure and Gaussian Models of Collective Structural Characteristics of Capped PEO Oligomers in Water. | Parallel-tempering MD results for a CH3(CH2-O-CH2)mCH3 chain in water are exploited as a database for analysis of collective structural characteristics of the PEO globule with a goal of defining models permitting statistical thermodynamic analysis of dispersants of Corexit type. The chain structure factor, relevant to ... | 25,121,580 | [
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... |
Circadian regulation of myocardial sarcomeric Titin-cap (Tcap, telethonin): identification of cardiac clock-controlled genes using open access bioinformatics data. | Circadian rhythms are important for healthy cardiovascular physiology and are regulated at the molecular level by a circadian clock mechanism. We and others previously demonstrated that 9-13% of the cardiac transcriptome is rhythmic over 24 h daily cycles; the heart is genetically a different organ day versus night. Ho... | 25,121,604 | [
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Temperature and food influence shell growth and mantle gene expression of shell matrix proteins in the pearl oyster Pinctada margaritifera. | In this study, we analyzed the combined effect of microalgal concentration and temperature on the shell growth of the bivalve Pinctada margaritifera and the molecular mechanisms underlying this biomineralization process. Shell growth was measured after two months of rearing in experimental conditions, using calcein sta... | 25,121,605 | [
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Impact of hormone-associated resistance to activated protein C on the thrombotic potential of oral contraceptives: a prospective observational study. | The increased thrombotic risk of oral contraceptives (OC) has been attributed to various alterations of the hemostatic system, including acquired resistance to activated protein C (APC). To evaluate to what extent OC-associated APC resistance induces a prothrombotic state we monitored plasma levels of thrombin and mole... | 25,121,606 | [
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Cadherin cytoplasmic domains inhibit the cell surface localization of endogenous E-cadherin, blocking desmosome and tight junction formation and inducing cell dissociation. | The downregulation of E-cadherin function has fundamental consequences with respect to cancer progression, and occurs as part of the epithelial-mesenchymal transition (EMT). In this study, we show that the expression of the Discosoma sp. red fluorescent protein (DsRed)-tagged cadherin cytoplasmic domain in cells inhibi... | 25,121,615 | [
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Adjuvant Gemcitabine and Gemcitabine-based Chemoradiotherapy Versus Gemcitabine Alone After Pancreatic Cancer Resection: The Indiana University Experience. | Adjuvant therapy after surgical resection is the current standard for pancreatic adenocarcinoma; however, the role of chemoradiotherapy (CRT) remains unclear. This study was conducted to compare the efficacy outcomes with adjuvant gemcitabine and gemcitabine-based CRT (CT-CRT) versus gemcitabine chemotherapy (CT) alone... | 25,121,637 | [
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Control of chromaticity by phosphor in glasses with low temperature sintered silicate glasses for LED applications. | Phosphor-in-glass (PiG) color converters for LED applications were fabricated with a mixture of phosphors, Y₃Al₅O₁₂:Ce³⁺ (yellow) and CaAlSiN₃:Eu²⁺ (red). The low sintering temperature (550°C) of SiO₂-Na₂O-RO (R=Ba, Zn) glass powder enabled the inclusion of CaAlSiN₃:Eu²⁺ (red) phosphor which cannot be embedded with con... | 25,121,657 | [
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Flexible operability and amplification of gray pulses. | We have investigated experimentally the flexible production and amplification of gray pulses for the first time to our knowledge. Switchable wavelengths, tunable pulse-widths, and adjustable contrasts have all been obtained in a fiber laser. Amplification of gray pulses was also experimentally investigated in detail. T... | 25,121,665 | [
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Surface and thickness profile measurement of a transparent film by three-wavelength vertical scanning interferometry. | We have developed a novel areal film thickness and topography measurement method using three-wavelength interferometry. The method simultaneously estimates the profiles of the front and back surfaces and the thickness distribution of a transparent film by model-based separation of two overlapped signals in an interfero... | 25,121,679 | [
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Incoherent-light temporal stretching of high-speed intensity waveforms. | We propose and demonstrate experimentally the first incoherent-light scheme for temporal imaging (magnification) of intensity waveforms. The scheme is based on a time-domain equivalent of a pinhole camera under incoherent illumination, involving two dispersive lines and temporal intensity modulation with a short gate. ... | 25,121,697 | [
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Heterodyne-detected and ultrafast time-resolved second-harmonic generation for sensitive measurements of charge transfer. | In organic photovoltaics many key ultrafast processes occur at the interface between electron donor and acceptor molecules. Traditional ultrafast spectroscopies, such as pump-probe or time-resolved fluorescence, are not ideal for studying the interface because most of their signal is from the bulk material. Time-resolv... | 25,121,705 | [
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Experimental study on the dynamics of polarized strong optical injection in 1550 nm VCSELs. | We have experimentally analyzed the dynamics of polarized strong optical injection in 1550 nm vertical-cavity surface-emitting lasers (VCSELs). The locking ranges of optical injection-locked (OIL) VCSELs are experimentally measured in different states of polarized strong optical injection. Based on our novel ellipse mo... | 25,121,707 | [
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On resilience and acceptance in the transition to palliative care at the end of life. | Specialist palliative care is a prominent and expanding site of health service delivery, providing highly specialised care to people at the end of life. Its focus on the delivery of specialised life-enhancing care stands in contrast to biomedicine's general tendency towards life-prolonging intervention. This philosophi... | 25,121,725 | [
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0.149956... |
Hematology as a diagnostic tool in bovine medicine. | The objective of the current review is to provide the reader with an overview of the bovine hematological profile. Sample collection, bovine reference ranges, and cattle-specific characteristics of erythrocyte, leukocyte, and platelet parameters are reviewed. Furthermore, diseases associated with abnormalities in the c... | 25,121,728 | [
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0.2639875,
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Systematic comparison of non-invasive measures for the assessment of atrial fibrillation complexity: a step forward towards standardization of atrial fibrillation electrogram analysis. | To present a comparison of electrocardiogram-based non-invasive measures of atrial fibrillation (AF) substrate complexity computed on invasive animal recordings to discriminate between short-term and long-term AF. The final objective is the selection of an optimal sub-set of measures for AF complexity assessment. High-... | 25,121,730 | [
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A role for H2S in the microcirculation of newborns: the major metabolite of H2S (thiosulphate) is increased in preterm infants. | Excessive vasodilatation during the perinatal period is associated with cardiorespiratory instability in preterm neonates. Little evidence of the mechanisms controlling microvascular tone during circulatory transition exists. We hypothesised that hydrogen sulphide (H2S), an important regulator of microvascular reactivi... | 25,121,737 | [
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0.1728738,
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Neck circumference and body mass index as independent predictors of hypertension misclassification in patients suspected of having obstructive sleep apnea. | Twenty-four-hour ambulatory blood pressure monitoring (ABPM) seems to be the most accurate way of diagnosing hypertension in patients with obstructive sleep apnea (OSA). However, this diagnostic tool is expensive and time-consuming and is therefore not used routinely. We aimed to find baseline predictors that enable th... | 25,121,756 | [
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0.061265,
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Clinical course and progression-free survival of adult intracranial and spinal ependymoma patients. | Ependymomas are rare CNS tumors. Previous studies describing the clinical course of ependymoma patients were restricted to small sample sizes, often with patients at a specific institution. Clinically annotated ependymoma tissue samples from 19 institutions were centrally reviewed. Patients were all adults aged 18 year... | 25,121,770 | [
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0.01929396,
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0.2464505,
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The Staurotypus turtles and aves share the same origin of sex chromosomes but evolved different types of heterogametic sex determination. | Reptiles have a wide diversity of sex-determining mechanisms and types of sex chromosomes. Turtles exhibit temperature-dependent sex determination and genotypic sex determination, with male heterogametic (XX/XY) and female heterogametic (ZZ/ZW) sex chromosomes. Identification of sex chromosomes in many turtle species a... | 25,121,779 | [
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Effectiveness of prophylactic antibiotics in outpatient plastic surgery. | The effectiveness of prophylactic antibiotics has not been established for patients who undergo plastic surgery as outpatients, and consensus guidelines for antibiotic administration in clean-contaminated plastic surgery are not available. In a retrospective study of outpatients, the authors examined preoperative timin... | 25,121,784 | [
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0.03142164,
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An approach toward constructing the trioxadispiroketal core in the DEF-ring of (+)-spirastrellolide A. | A concise and stereoselective synthesis of the trioxadispiroketal motif that embodies the DEF-ring of the marine macrolide (+)-spirastrellolide A is described. The synthetic approach features a sequence of cyclic acetal tethered ring-closing metathesis and Suárez oxidative cyclization, thereby constituting a viable str... | 25,121,803 | [
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0.1828582,
0.1798698,
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Role of desorption kinetics in the rhamnolipid-enhanced biodegradation of polycyclic aromatic hydrocarbons. | The main aim of this study was to investigate the effect of a rhamnolipid biosurfactant on biodegradation of (14)C-labeled phenanthrene and pyrene under desorption-limiting conditions. The rhamnolipid caused a significant solubilization and enhanced biodegradation of PAHs sorbed to soils. The enhancement was, however, ... | 25,121,829 | [
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0.3966014,
-0.071669... |
Designing metal hemispheres on silicon ultrathin film solar cells for plasmonic light trapping. | We systematically investigate the design of two-dimensional silver (Ag) hemisphere arrays on crystalline silicon (c-Si) ultrathin film solar cells for plasmonic light trapping. The absorption in ultrathin films is governed by the excitation of Fabry-Perot TEMm modes. We demonstrate that metal hemispheres can enhance ab... | 25,121,839 | [
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152 W average power Tm-doped fiber CPA system. | A high-power thulium (Tm)-doped fiber chirped-pulse amplification system emitting a record compressed average output power of 152 W and 4 MW peak power is demonstrated. This result is enabled by utilizing Tm-doped photonic crystal fibers with mode-field diameters of 35 μm, which mitigate detrimental nonlinearities, exh... | 25,121,845 | [
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Nonlinear switching in a two-concentric-core chalcogenide glass optical fiber for passively mode-locking a fiber laser. | We propose an all-fiber mode-locking device, which operates based on nonlinear switching in a novel two-concentric-core fiber structure. The design is particularly attractive given the ease of fabrication and coupling to other components in a mode-locked fiber laser cavity. The nonlinear switching in this coupler is st... | 25,121,846 | [
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Photo-aligned ferroelectric liquid crystals in microchannels. | In this Letter we disclose a method to realize a good alignment of ferroelectric liquid crystals (FLCs) in microchannels, based on photo-alignment. The sulfonic azo dye used in our research offers variable anchoring energy depending on the irradiation energy and thus provides good control on the FLC alignment in microc... | 25,121,847 | [
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Controllable continuous-wave Nd:YVO₄ self-Raman lasers using intracavity adaptive optics. | A controllable self-Raman laser using an adaptive optics (AO)-based control loop featuring an intracavity deformable mirror is reported. This method has the potential to alleviate thermal lensing within the Raman and laser gain media, and enable solid-state Raman lasers to reach new power levels. A proof-of-concept exp... | 25,121,868 | [
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3D-printed miniature gas cell for photoacoustic spectroscopy of trace gases. | A new methodology for the development of miniature photoacoustic trace gas sensors using 3D printing is presented. A near-infrared distributed feedback (DFB) laser is used together with a polymer-based gas cell, off-the-shelf fiber optic collimators, and a microelectromechanical system (MEMS) microphone to measure acet... | 25,121,877 | [
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Interferometric fiber-optic bending/nano-displacement sensor using plastic dual-core fiber. | We demonstrate an interferometric fiber-optic bending/nano-displacement sensor based on a plastic dual-core fiber. The light coupled into the two fiber cores is first guided along the fiber, and then reflected by the mirror coated at the fiber end. Reflected light coming out of the fiber produces interference that shif... | 25,121,887 | [
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Narrow-linewidth quantum cascade laser at 8.6 μm. | We report on a narrow-linewidth distributed-feedback quantum cascade laser at 8.6 μm that is optical-feedback locked to a high-finesse V-shaped cavity. The spectral purity of the quantum cascade laser is fully characterized using a high-sensitivity optical frequency discriminator, leading to a 1 ms linewidth of less th... | 25,121,915 | [
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Polarization-diversified photonic comb filter with independently tunable free spectrum range. | A polarization-diversified photonic comb filter with tunable free spectrum range (FSR) is proposed using two variable differential group delay (DGD) elements in a loop configuration. Two different cosine transfer functions could be simultaneously realized on orthogonal polarization states. Experimental demonstrations a... | 25,121,921 | [
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Cholesterol selectively regulates IL-5 induced mitogen activated protein kinase signaling in human eosinophils. | Eosinophils function contributes to human allergic and autoimmune diseases, many of which currently lack curative treatment. Development of more effective treatments for eosinophil-related diseases requires expanded understanding of eosinophil signaling and biology. Cell signaling requires integration of extracellular ... | 25,121,926 | [
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Registered nurses, nurse specialists and physicians have a neutral to moderately positive view on nurse prescribing, though physicians still have patient safety concerns. | Implications for practice and research: The process of assigning medical roles to nurses has to be gradual and stepwise. The influence of this process on the consequences for the nursing and medical professions, and for the quality of care, should be investigated further. | 25,121,933 | [
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Magnetic reflectometry of heterostructures. | Measuring the magnetic configuration at complex buried layers and interfaces is an important task, which requires especially a non-destructive probing technique. X-ray resonant magnetic reflectometry (XRMR) combines the non-destructive depth profiling potential of x-ray reflectometry with the excellent sensitivity for ... | 25,121,937 | [
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Coronal fracture of the scaphoid--a case report and literature review. | Coronal fracture of the scaphoid is a rare configuration of scaphoid fracture. Only three cases have been found to be reported in English literature. In our case, a 25-year-old man sustained right wrist injury after a fall with an outstretched hand, was suspected of suffering from a scaphoid fracture as shown on the pr... | 25,121,939 | [
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Bilateral bipartite carpal scaphoid: a case report and literature review. | Congenital bipartite carpal scaphoid has been reported as an extremely rare congenital anomaly. We report a case of a 47-year-old man who was found with bilateral bipartite carpal scaphoids with no history of injury. Radiographs demonstrated symmetric findings of the distinct bipartition of the scaphoid without obvious... | 25,121,941 | [
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Associations between ulnar nerve strain and accompanying conditions in patients with cubital tunnel syndrome. | Pathophysiology of cubital tunnel syndrome (CubTS) is still controversial. Ulnar nerve strain at the elbow was measured intraoperatively in 13 patients with CubTS before simple decompression. The patients were divided into three groups according to their accompanying conditions: compression/adhesion, idiopathic, and re... | 25,121,945 | [
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Treatment of hook of the hamate fractures in adults using low-intensity pulsed ultrasound. | Two delayed unions and one nonunion of hook of the hamate fractures in adults aged 31-, 40-, and 41-years-old were treated with low-intensity pulsed ultrasound (LIPUS). Ultrasound treatment was started at three, four, and six months after injury and ultrasound exposure at the hook of the hamate in the hypothenar eminen... | 25,121,946 | [
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WW domain folding complexity revealed by infrared spectroscopy. | Although the intrinsic tryptophan fluorescence of proteins offers a convenient probe of protein folding, interpretation of the fluorescence spectrum is often difficult because it is sensitive to both global and local changes. Infrared (IR) spectroscopy offers a complementary measure of structural changes involved in pr... | 25,121,968 | [
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iNitro-Tyr: prediction of nitrotyrosine sites in proteins with general pseudo amino acid composition. | Nitrotyrosine is one of the post-translational modifications (PTMs) in proteins that occurs when their tyrosine residue is nitrated. Compared with healthy people, a remarkably increased level of nitrotyrosine is detected in those suffering from rheumatoid arthritis, septic shock, and coeliac disease. Given an uncharact... | 25,121,969 | [
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Who Seeks Cita Con El Doctor? Twelve Years of Spanish-Language Radio Program Targeting U.S. Latinos. | Spanish-dominant Latinos make up 13% of the U.S. population, and this group is poorer and faces multiple threats to health compared with the general population. Additionally, Spanish speakers face challenges accessing health information that is often not available in Spanish. This study provides a descriptive epidemiol... | 25,121,981 | [
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Epoxy alcohol synthase of the rice blast fungus represents a novel subfamily of dioxygenase-cytochrome P450 fusion enzymes. | The genome of the rice blast fungus Magnaporthe oryzae codes for two proteins with N-terminal dioxygenase (DOX) and C-terminal cytochrome P450 (CYP) domains, respectively. One of them, MGG_13239, was confirmed as 7,8-linoleate diol synthase by prokaryotic expression. The other recombinant protein (MGG_10859) possessed ... | 25,121,983 | [
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Repair-related activation of hedgehog signaling in stromal cells promotes intrahepatic hypothyroidism. | Thyroid hormone (TH) is important for tissue repair because it regulates cellular differentiation. Intrahepatic TH activity is controlled by both serum TH levels and hepatic deiodinases. TH substrate (T4) is converted into active hormone (T3) by deiodinase 1 (D1) but into inactive hormone (rT3) by deiodinase 3 (D3). Al... | 25,121,996 | [
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A supersandwich electrochemiluminescence immunosensor based on mimic-intramolecular interaction for sensitive detection of proteins. | An electrochemiluminescence (ECL) immunoassay protocol was developed based on mimic-intramolecular interaction for sensitive detection of prostate specific antigen (PSA). It was constructed by integrating the ECL luminophore (tris(4,4'-dicarboxylicacid-2,2'-bipyridyl)-ruthenium(ii)dichloride (Ru(dcbpy)3(2+))) and corea... | 25,122,008 | [
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Use of research evidence in state policymaking for childhood obesity prevention in Minnesota. | We describe how scientific evidence about obesity has been used in Minnesota legislative materials to understand how research evidence might more effectively be translated into policymaking. We selected 13 obesity-related bills introduced from 2007 to 2011 in Minnesota. Using state archives, we collected all legislativ... | 25,122,015 | [
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CYP2C19 variation, not citalopram dose nor serum level, is associated with QTc prolongation. | Recently, a FDA Safety Communication warned of a dose-dependent risk for QTc prolongation with citalopram, which is metabolized by CYP2C19 of the cytochrome P450 system. We investigate associations between citalopram and escitalopram dose, serum concentration, CYP2C19 phenotype, and QTc. We undertook a retrospective ch... | 25,122,046 | [
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In vitro selection, characterization, and biosensing application of high-affinity cylindrospermopsin-targeting aptamers. | Contamination of freshwater with cyanotoxin cylindrospermopsin (CYN) represents a significant global concern for public health. The sensitive detection of CYN is necessary to effectively manage and control the treatment of water resources. Here we report a novel, highly sensitive label-free aptasensor for CYN analysis,... | 25,122,072 | [
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Lower gastrointestinal bleeding associated with diclofenac topical patch in a patient with colonic mass and on antiplatelet therapy for atrial fibrillation. | Topical formulations of diclofenac, a nonsteroidal anti-inflammatory drug commonly prescribed to treat musculoskeletal complaints such as osteoarthritis, low back pain, and myofascial pain, are available in the form of a solution, gel, and patch. The topical application of diclofenac results in substantially lower syst... | 25,122,100 | [
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The frequency and determinants of liver stiffness measurement failure: a retrospective study of "real-life" 38,464 examinations. | To investigate the frequency and determinants of liver stiffness measurement (LSM) failure by means of FibroScan in "real-life" Chinese patients. A total of 38,464 "real-life" Chinese patients in 302 military hospital of China through the whole year of 2013, including asymptomatic carrier, chronic hepatitis B, chronic ... | 25,122,123 | [
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Ways of coping with stress and perceived social support in gynecologic cancer patients. | Stress is commonly encountered among cancer patients and may be a challenge affecting immune system resistance. Social support may contribute positively to the health of cancer patients, playing a role in coping with stress. The aim of this study was to determine whether ways of coping are related to social support giv... | 25,122,133 | [
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... |
Inhibition of the TRAIL death receptor by CMV reveals its importance in NK cell-mediated antiviral defense. | TNF-related apoptosis inducing ligand (TRAIL) death receptors (DR) regulate apoptosis and inflammation, but their role in antiviral defense is poorly understood. Cytomegaloviruses (CMV) encode many immune-modulatory genes that shape host immunity, and they utilize multiple strategies to target the TNF-family cytokines.... | 25,122,141 | [
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Exceptional aggressiveness of cerebral cavernous malformation disease associated with PDCD10 mutations. | The phenotypic manifestations of cerebral cavernous malformation disease caused by rare PDCD10 mutations have not been systematically examined, and a mechanistic link to Rho kinase-mediated hyperpermeability, a potential therapeutic target, has not been established. We analyzed PDCD10 small interfering RNA-treated endo... | 25,122,144 | [
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... |
Feasibility study to quantify the auditory and social environment of older adults using a digital language processor. | To investigate the feasibility of using a digital language processor (DLP) to objectively quantify the auditory and social environment of older adults. Thirty-seven participants aged 64 to 91 years residing in a retirement community were asked to wear a DLP to record their auditory and language environment during 1 wak... | 25,122,146 | [
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The Arabidopsis 14-3-3 protein RARE COLD INDUCIBLE 1A links low-temperature response and ethylene biosynthesis to regulate freezing tolerance and cold acclimation. | In plants, the expression of 14-3-3 genes reacts to various adverse environmental conditions, including cold, high salt, and drought. Although these results suggest that 14-3-3 proteins have the potential to regulate plant responses to abiotic stresses, their role in such responses remains poorly understood. Previously... | 25,122,152 | [
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Structure of chitosan determines its interactions with mucin. | Synthetic and natural mucoadhesive biomaterials in optimized galenical formulations are potentially useful for the transmucosal delivery of active ingredients to improve their localized and prolonged effects. Chitosans (CS) have potent mucoadhesive characteristics, but the exact mechanisms underpinning such interaction... | 25,122,160 | [
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ATO/ATRA/anthracycline-chemotherapy sequential consolidation achieves long-term efficacy in primary acute promyelocytic leukemia. | The combination of all-trans retinoic acid (ATRA) and arsenic trioxide (As2O3, ATO) has been effective in obtaining high clinical complete remission (CR) rates in acute promyelocytic leukemia (APL), but the long-term efficacy and safety among newly diagnosed APL patients are unclear. In this retrospective study, total ... | 25,122,165 | [
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MicroRNA-30e* suppresses dengue virus replication by promoting NF-κB-dependent IFN production. | MicroRNAs have been shown to contribute to a repertoire of host-pathogen interactions during viral infection. Our previous study demonstrated that microRNA-30e* (miR-30e*) directly targeted the IκBα 3'-UTR and disrupted the NF-κB/IκBα negative feedback loop, leading to hyperactivation of NF-κB. This current study inves... | 25,122,182 | [
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Inner and outer portions of colonic circular muscle: ultrastructural and immunohistochemical changes in rat chronically treated with otilonium bromide. | Rat colonic circular muscle, main target of otilonium bromide (OB) spasmolytic activity, is subdivided in an inner and outer portion. Since the inner one is particularly rich in organelles involved in calcium availability (caveolae, smooth endoplasmic reticulum, mitochondria), the expression of specific markers (Caveol... | 25,122,192 | [
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0.139... |
A scalable and accurate targeted gene assembly tool (SAT-Assembler) for next-generation sequencing data. | Gene assembly, which recovers gene segments from short reads, is an important step in functional analysis of next-generation sequencing data. Lacking quality reference genomes, de novo assembly is commonly used for RNA-Seq data of non-model organisms and metagenomic data. However, heterogeneous sequence coverage caused... | 25,122,209 | [
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Scaling-up access to antiretroviral therapy for children: a cohort study evaluating care and treatment at mobile and hospital-affiliated HIV clinics in rural Zambia. | Travel time and distance are barriers to care for HIV-infected children in rural sub-Saharan Africa. Decentralization of care is one strategy to scale-up access to antiretroviral therapy (ART), but few programs have been evaluated. We compared outcomes for children receiving care in mobile and hospital-affiliated HIV c... | 25,122,213 | [
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0.1375633,
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Evidence for two types of lateral interactions in visual perception of temporal signals. | The aim of this work was to investigate the mechanisms of lateral interactions involved in flicker perception. Furthermore, the spatial properties of the monoptic and dichoptic components of these mechanisms were studied. We quantified the perceived flicker strength (PFS) in the center of a test stimulus, which was sim... | 25,122,214 | [
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0.2242285,
0.059... |
Consistent inference of a general model using the pseudolikelihood method. | Recently, a maximum pseudolikelihood (MPL) inference method has been successfully applied to statistical physics models with intractable likelihoods. We use information theory to derive a relation between the pseudolikelihood and likelihood functions. Furthermore, we show the consistency of the pseudolikelihood method ... | 25,122,234 | [
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0.3668348,
0.2344918,
0.0245865,
0.0157361,
0.1... |
Small-cluster renormalization group in Ising and Blume-Emery-Griffiths models with ferromagnetic, antiferromagnetic, and quenched disordered magnetic interactions. | The Ising and Blume-Emery-Griffiths (BEG) models' critical behavior is analyzed in two dimensions and three dimensions by means of a renormalization group scheme on small clusters made of a few lattice cells. Different kinds of cells are proposed for both ordered and disordered model cases. In particular, cells preserv... | 25,122,256 | [
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0.09129639,
0.1393996,
0.04879843,
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... |
Dynamic hysteretic features of Ising-type thin films. | In order to elucidate the nature of hysteresis characteristics in a magnetic Ising-type thin film with a certain thickness, such as types of frequency dispersion curves, decay of hysteresis loop area, corresponding coercive field and remanent magnetization values, etc., we investigate the hysteretic response of each la... | 25,122,273 | [
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-0.06046151,
0.3617271,
0.06511073,
-0.15... |
Rare regions and Griffiths singularities at a clean critical point: the five-dimensional disordered contact process. | We investigate the nonequilibrium phase transition of the disordered contact process in five space dimensions by means of optimal fluctuation theory and Monte Carlo simulations. We find that the critical behavior is of mean-field type, i.e., identical to that of the clean five-dimensional contact process. It is accompa... | 25,122,283 | [
-0.08254218,
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0.1692887,
-0.1467218,
0.03812296,
0.01948545,
-0.1917... |
Work and efficiency of quantum Otto cycles in power-law trapping potentials. | We study the performance of a quantum Otto cycle operating in trapping potentials of different shapes. We show that, while both the mean work output and the efficiency of two Otto cycles in different trapping potentials can be made equal, the work probability distribution will still be strongly affected by the differen... | 25,122,289 | [
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0.05416954,
0.1347174,
0.05898591,
0.1392007,
0.08634152,
-0.2618728,... |
Heat transfer in the spin-boson model: a comparative study in the incoherent tunneling regime. | We study the transfer of heat in the nonequilibrium spin-boson model with an Ohmic dissipation. In the nonadiabatic limit we derive a formula for the thermal conductance based on a rate equation formalism at the level of the noninteracting blip approximation, valid for temperatures T>T(K), with T(K) as the Kondo tem... | 25,122,292 | [
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0.02695594,
-0.03154228,
0.1079614,
0.2100036,
-0.09695575,
0.078... |
Effect of size polydispersity versus particle shape in dense granular media. | We present a detailed analysis of the morphology of granular systems composed of frictionless pentagonal particles by varying systematically both the size span and particle shape irregularity, which represent two polydispersity parameters of the system. The microstructure is characterized in terms of various statistica... | 25,122,294 | [
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0.1435466,
0.06893754,
0.07504822,
0.4205335,
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-0.... |
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