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Usage patterns of biomarkers in non-small-cell lung cancer patients in India: Findings from a systematic review and survey. | Personalized medicine has facilitated improved management of non-small cell lung cancer (NSCLC) patients by identifying predictive and prognostic biomarkers for enhanced efficiency of detection and efficacy of treatment. This systematic review and survey assessed the patterns of biomarker usage, molecular testing techn... | 25,125,812 | [
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Primary synovial sarcoma of lung. | A synovial sarcoma (SS) is a rare form of cancer which usually occurs near the joints of the arm, neck, or leg, but has been documented in most human tissues and organs, including the brain, prostate, and heart. Primary pulmonary SS is an extremely rare tumor. We report a case of primary SS of lung who presented with s... | 25,125,819 | [
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Evaluation of fracture resistance of roots obturated with resilon and thermoplasticized gutta-percha: An in vitro study. | To investigate and compare the fracture resistance of resilon and realseal filled root canals with those that were obturated with thermoplasticized gutta-percha and AH-plus endodontic sealer. Eighty extracted human mandibular single-rooted premolars stored in 10% formalin were used in this study. They were prepared by ... | 25,125,849 | [
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Comparison of surface abrasion produced on the enamel surface by a standard dentifrice using three different toothbrush bristle designs: A profilometric in vitro study. | The aim was to assess, in vitro, the effect on surface abrasivity of enamel surface caused by three different types (flat trim, zig-zag, bi-level) of toothbrush bristle design. Twenty-four freshly extracted, sound, human incisor teeth were collected for this study. The enamel slab was prepared, which were mounted, on s... | 25,125,852 | [
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Comparison of the cleaning efficacy of EndoVac with conventional irrigation needles in debris removal from root canal. An in-vivo study. | The aims were to evaluate the root canal debris removal after irrigation with EndoVac system and to compare its efficacy with Max-i-Probe needles. Fifteen matched pairs of single canalled vital teeth with mature apices indicated for extraction were selected. After working length determination and biomechanical preparat... | 25,125,853 | [
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Type II canal configuration and Type I Dens invaginatus. | The prevalent notion about maxillary central incisor with normal external morphology is a tooth with single root and root canal. A case in which all four maxillary incisors were having Type II canal configurations (Vertucci's classification) is reported, in addition, the lateral incisors revealed dens invaginatus with ... | 25,125,855 | [
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Cone beam computed tomography evaluation and endodontic management of permanent mandibular second molar with four roots: A rare case report and literature review. | The morphological variation in the number of roots and root canals, especially in multi-rooted teeth is a constant challenge for diagnosis and successful endodontic therapy. Knowledge of the most common anatomic characteristics and their possible variations is fundamental. Although, endodontic management of four-rooted... | 25,125,856 | [
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Use of quartz fiber post for reattachment of complex crown root fractures: A 4-year follow-up. | Dental hard tissue trauma is among the most common cases encountered in dental practice. Simple tooth fractures, which occur due to sharp blows, are widely seen in all age groups, especially in young adults. If in case of complex fractures the fractured tooth fragments are available to the dentist in a clean and hydrat... | 25,125,857 | [
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Poor health related quality of life among patients of sickle cell disease. | Sickle cell disease (SCD) is characterized by chronic hemolytic anemia and vascular occlusion, causing recurrent painful episodes, neuro-cognitive deficits, organ failures and death in early adulthood. Besides the medical consequences, most of the families with a child of SCD have to cope with financial and social cris... | 25,125,865 | [
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Quality of life in cancer patients undergoing chemotherapy in a tertiary care center in malwa region of punjab. | The objective of this prospective, non-interventional, 4-month observational study was to analyze and compare patient-reported quality of life (QOL) and their physical/psychosocial symptom burden during their respective chemotherapy sessions. A prospective and descriptive study was carried out jointly by Pharmacology a... | 25,125,867 | [
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Rubus fruticosus (blackberry) use as an herbal medicine. | Wild grown European blackberry Rubus fruticosus) plants are widespread in different parts of northern countries and have been extensively used in herbal medicine. The result show that European blackberry plants are used for herbal medicinal purpose such as antimicrobial, anticancer, antidysentery, antidiabetic, antidia... | 25,125,882 | [
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Value addition in sesame: A perspective on bioactive components for enhancing utility and profitability. | Sesame seed is a reservoir of nutritional components with numerous beneficial effects along with health promotion in humans. The bioactive components present in the seed include vital minerals, vitamins, phytosterols, polyunsaturated fatty acids, tocopherols and unique class of lignans such as sesamin and sesamolin. Th... | 25,125,886 | [
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Safety of latex urinary catheters for the short time drainage. | In this study, we attempt to identify the most appropriate catheter (silicone vs. latex) for short-term urinary catheterization. We compared the post-operative clinico-pathological complications between latex and silicone for short term catheterization in rabbits with hypospadias. Forty rabbits were used in our study t... | 25,125,890 | [
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Functional hyposplenism. | Functional hyposplenism is a condition accompanying many diseases such as sickle cell disease, celiac disease, alcoholic liver disease, hepatic cirrhosis, lymphomas and autoimmune disorders. It is characterised mostly by defective immune responses against infectious agents, especially encapsulated organisms, since the ... | 25,125,944 | [
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Effect of exhaust emissions on carbon monoxide levels in employees working at indoor car wash facilities. | Exhaust emissions from motor vehicles threaten the environment and human health. Carbon monoxide (CO) poisoning, especially the use of exhaust gas CO in suicidal attempts is well known in the literature. Recently, indoor car wash facilities established in large shopping malls with closed parking, lots is a new risk are... | 25,125,950 | [
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Memory Decline in Peri- and Post-menopausal Women: The Potential of Mind-Body Medicine to Improve Cognitive Performance. | Cognitive decline is a frequent complaint during the menopause transition and among post-menopausal women. Changes in memory correspond with diminished estrogen production. Further, many peri- and post-menopausal women report sleep concerns, depression, and hot flashes, and these factors may contribute to cognitive dec... | 25,125,972 | [
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Subcutaneously administered methotrexate for rheumatoid arthritis, by prefilled syringes versus prefilled pens: patient preference and comparison of the self-injection experience. | This multicenter, randomized, crossover study compared preference, ease of use, acceptability, satisfaction, and safety of repeated subcutaneous (SC) self-administrations with prefilled pens and prefilled syringes delivering methotrexate (MTX), in patients with rheumatoid arthritis (RA). The study (ClinicalTrials.gov n... | 25,125,973 | [
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Influence of diet and obesity on COPD development and outcomes. | The global increase in the prevalence and incidence of obesity has called serious attention to this issue as a major public health concern. Obesity is associated with many chronic diseases, including cardiovascular disease and diabetes, and recently the role of overweight and obesity in lung disease has received new in... | 25,125,974 | [
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Serum cytokine profiling and enrichment analysis reveal the involvement of immunological and inflammatory pathways in stable patients with chronic obstructive pulmonary disease. | Chronic obstructive pulmonary disease (COPD) is a major global health problem. It results from chronic inflammation and causes irreversible airway damage. Levels of different serum cytokines could be surrogate biomarkers for inflammation and lung function in COPD. We aimed to determine the serum levels of different bio... | 25,125,975 | [
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Improvement of quality and safety in health care as a new interprofessional learning module - evaluation from students. | Interprofessional teamwork is in many ways a norm in modern health care, and needs to be taught during professional education. This study is an evaluation of a newly introduced and mandatory learning module where students from different health profession programs used Improvement of Quality and Safety as a way to devel... | 25,125,983 | [
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Pediatricians' perceptions of clinical practice guidelines. | Clinical practice guidelines (CPGs) are propositions for health care providers about the care of patients and are usually described as "systematically developed statements to assist practitioners' and patients' decisions about appropriate health care for specific circumstances". The purpose of this study was to investi... | 25,125,984 | [
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Use of frameless intrauterine devices and systems in young nulliparous and adolescent women: results of a multicenter study. | The purpose of this study was to provide additional data on the experience with frameless copper and levonorgestrel (LNG) intrauterine devices (IUDs) in nulliparous and adolescent women. Nulliparous and adolescent women, 25 years of age or younger, using the frameless copper IUD or the frameless LNG-releasing intrauter... | 25,125,987 | [
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Prevalence and factors associated with congenital malformations in tirana, Albania, during 2011-2013. | Congenital Malformations (CMs) represent a challenge especially for developing countries. Data about CMs in Albania are rather scarce. In this context, our aim was to assess the prevalence and factors associated with CMs in Tirana, the capital of Albania. Information on all CMs at birth during 2011-2013 was retrieved f... | 25,126,007 | [
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Effect of cigarette smoking in pregnancy on infants anthropometric characteristics. | The main goal of this research is to correlate anthropometric characteristics of newborns in pregnant women who consume cigarettes during pregnancy. The study was conducted at the Obstetrics Clinic of the Clinical Center, University of Sarajevo. The retrospective study covered a period of two years. Main inclusion crit... | 25,126,013 | [
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Effects of lipoic Acid on acrylamide induced testicular damage. | Acrylamide is very toxic to various organs and associated with significant increase of oxidative stress and depletion of antioxidants. Alpha-lipoic acid enhances cellular antioxidant defense capacity, thereby protecting cells from oxidative stress. This study aimed to evaluate the protective role of alpha-lipoic acid o... | 25,126,019 | [
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Pathomechanisms in coenzyme q10-deficient human fibroblasts. | Primary coenzyme Q10 (CoQ10) deficiency is a rare mitochondrial disorder associated with 5 major clinical phenotypes: (1) encephalomyopathy, (2) severe infantile multisystemic disease, (3) cerebellar ataxia, (4) isolated myopathy, and (5) steroid-resistant nephrotic syndrome. Growth retardation, deafness and hearing lo... | 25,126,049 | [
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Learning to perceive in the sensorimotor approach: Piaget's theory of equilibration interpreted dynamically. | if understanding is required for perception, how can we learn to perceive something new, something we do not yet understand? According to the sensorimotor approach, perception involves mastery of regular sensorimotor co-variations that depend on the agent and the environment, also known as the "laws" of sensorimotor co... | 25,126,065 | [
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Pydpiper: a flexible toolkit for constructing novel registration pipelines. | Using neuroimaging technologies to elucidate the relationship between genotype and phenotype and brain and behavior will be a key contribution to biomedical research in the twenty-first century. Among the many methods for analyzing neuroimaging data, image registration deserves particular attention due to its wide rang... | 25,126,069 | [
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... |
An intraductal papillary neoplasm of the bile duct at the duodenal papilla. | In recent years, the disease concept of intraductal papillary neoplasm of the bile duct (IPNB) has been attracting attention as a biliary lesion that is morphologically similar to intraductal papillary mucinous neoplasm (IPMN), which is considered to be a counterpart of IPMN. However, there are few reports on IPNB, and... | 25,126,070 | [
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A Prospective Phase I/II Study: Combination Chemotherapy with Docetaxel and Pemetrexed as Second-Line Treatment in Patients with Stage IIIB/IV Non-Small Cell Lung Cancer. | Two standard single-agent chemotherapy treatments (docetaxel and pemetrexed) were combined in this trial and administered as second-line treatment in patients with non-small cell lung cancer (NSCLC). The aim of this study was to evaluate the safety and feasibility of combining docetaxel with pemetrexed. Six patients we... | 25,126,073 | [
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Lithium suppresses Aβ pathology by inhibiting translation in an adult Drosophila model of Alzheimer's disease. | The greatest risk factor for Alzheimer's disease (AD) is age, and changes in the ageing nervous system are likely contributors to AD pathology. Amyloid beta (Aβ) accumulation, which occurs as a result of the amyloidogenic processing of amyloid precursor protein (APP), is thought to initiate the pathogenesis of AD, even... | 25,126,078 | [
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The cortical microstructural basis of lateralized cognition: a review. | The presence of asymmetry in the human cerebral hemispheres is detectable at both the macroscopic and microscopic scales. The horizontal expansion of cortical surface during development (within individual brains), and across evolutionary time (between species), is largely due to the proliferation and spacing of the mic... | 25,126,082 | [
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Automatic blastomere recognition from a single embryo image. | The number of blastomeres of human day 3 embryos is one of the most important criteria for evaluating embryo viability. However, due to the transparency and overlap of blastomeres, it is a challenge to recognize blastomeres automatically using a single embryo image. This study proposes an approach based on least square... | 25,126,108 | [
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ProBLM web server: protein and membrane placement and orientation package. | The 3D structures of membrane proteins are typically determined without the presence of a lipid bilayer. For the purpose of studying the role of membranes on the wild type characteristics of the corresponding protein, determining the position and orientation of transmembrane proteins within a membrane environment is hi... | 25,126,110 | [
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Cerebral aspergilloma in a SLE patient: A case report with short literature review. | Aspergillosis of brain is very rare, and commonly seen in immunocompromised or immunosuppressed patient. Here, we report a cerebral aspergillosis condition in a late teen girl who is a Systemic Lupus Erythromatosis patient with steroid therapy. She developed headaches, vomitings, and convulsions. On the basis of clinic... | 25,126,119 | [
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Multicystic oligodendroglioma with calvarial destruction. | Calvarial erosion is known to occur with some superficially located tumors. Very few case reports of calvarial erosion associated with oligodendroglioma are reported in the literature, but calvarial destruction with oligodendroglioma is very rare. To report an unusual case of multicystic frontoparietal oligodendrogliom... | 25,126,125 | [
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Impact of emergency contraception status on unintended pregnancy: observational data from a women's health practice. | This study aimed to determine if nonprescription emergency contraception (EC) availability impacted self-reported unintended pregnancy rates and to assess women's knowledge and awareness of EC prior to and after nonprescription availability. A survey regarding contraception use and knowledge was verbally administered t... | 25,126,137 | [
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Adherence policy, education and practice - an international perspective. | Nonadherence to chronic therapy has become a large burden on the healthcare system of many countries. Community pharmacists are well positioned to address nonadherence as part of their overall patient care activities, and contribute to patients' quality use of medicines. Between 2008 and 2010, a series of narrative, pe... | 25,126,142 | [
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Granulocyte colony-stimulating factor use in a large British hospital: comparison with published experience. | Granulocyte colony-stimulating factors (G-CSF) are high-cost agents recommended as prophylaxis of febrile neutropenia or as adjunctive treatment of severe neutropenic sepsis. Their use in high-risk situations such as acute myeloid leukaemia, acute lymphocytic leukaemia, myelodysplastic syndrome and stem cell transplant... | 25,126,143 | [
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Evaluation of a pharmacist-managed diabetes medication therapy adherence clinic. | Patient adherence to prescribed medication regimens is important in diabetes care to prevent or delay microvascular and macrovascular complications such as retinopathy, nephropathy and myocardial infarction. In Penang Hospital, Malaysia, pharmacists collaborate with physicians in diabetes care through a pharmacist-mana... | 25,126,149 | [
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Steering Fluorescence Emission with Metal-Dielectric-Metal Structures of Au, Ag and Al. | Directional control over fluorescence emission is important for improving the sensitivity of fluorescence based techniques. In recent years, plasmonic and photonic structures have shown great promise in shaping the spectral and spatial distribution of fluorescence, which otherwise is typically isotropic in nature and i... | 25,126,154 | [
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Oropharyngeal airway changes after rapid maxillary expansion: the state of the art. | The aim of this article is to elucidate the state of the art about how rapid maxillary expansion (RME) produces changes in the oropharyngeal airways in terms of CBCT (Cone Beam Computed Tomography) data during the growth period, according to the available literature. Electronic search was done from January 2009 to Apri... | 25,126,159 | [
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Combined effects of astragalus soup and persistent Taiji boxing on improving the immunity of elderly women. | To observe the combined effects of astragalus soup and persistent Taiji boxing on improving the immunity of women of advanced years. 120 elderly women lacking daily exercise were chosen as the study subjects. By using the table of random numbers, they were then divided into the control group and the experiment group, c... | 25,126,193 | [
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Pulmonary epithelioid hemangioendothelioma coexisting with pulmonary nodular amyloidosis: case discussion and review of the literature. | A 38-year-old female was found to have multiple bilateral lung nodules in a routine chest X-ray examination. Thoracoscopy was performed with biopsy of three nodules from the right lower lobe and Congo red staining showed typical amyloid pattern. Initial diagnosis of pulmonary nodular amyloidosis was made. However, one ... | 25,126,197 | [
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The beneficial effect of melatonin in brain endothelial cells against oxygen-glucose deprivation followed by reperfusion-induced injury. | Melatonin has a cellular protective effect in cerebrovascular and neurodegenerative diseases. Protection of brain endothelial cells against hypoxia and oxidative stress is important for treatment of central nervous system (CNS) diseases, since brain endothelial cells constitute the blood brain barrier (BBB). In the pre... | 25,126,203 | [
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When novelty is not enough. | Neither orderly nor fully rational, the current healthcare environment is a mosaic of providers, products, services, and intermediaries delivering healthcare, regulatory, and other government institutions, and consumers. The information required for informed healthcare decisions for novel pharmaceutical interventions v... | 25,126,215 | [
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Evaluation and management of diabetes mellitus. | Diabetes mellitus is a major public health problem with tremendous medical and economic burdens. It is the seventh leading cause of death and the number one cause of end-stage renal disease, adult blindness, impotence, and nontraumatic lower-limb amputation in the United States. People with diabetes are 2 to 4 times mo... | 25,126,259 | [
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Economic Evaluation of Quality-of-Life Improvement with Second-Generation Antihistamines and Montelukast in Patients with Allergic Rhinitis. | Allergic rhinitis causes significant economic losses and substantial reductions in quality of life. Improving a patient's symptoms can therefore enhance the patient's quality of life. To measure the relative cost-effectiveness of prescription second-generation antihistamines (levocetirizine, desloratadine, and fexofena... | 25,126,304 | [
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Engaging providers in medication adherence: a health plan case study. | Nonadherence to treatment regimens is a common, costly, and complex problem that is often overlooked in a busy primary care setting. The goals of this study were to raise providers' awareness of nonadherence among their patients, to identify the reasons for lack of adherence, and engage physicians in addressing these b... | 25,126,330 | [
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Strategies to prevent opioid misuse, abuse, and diversion that may also reduce the associated costs. | The use of prescription opioid drugs has the potential to lead to patient abuse of these medications, addiction, and diversion. Such an abuse is associated with increased costs because of excessive healthcare utilization. Finding ways to minimize the risk for abuse and addiction can enhance patient outcomes and reduce ... | 25,126,342 | [
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Obesity in the workplace: impact on cardiovascular disease, cost, and utilization of care. | In forecasting the future of cardiovascular disease (CVD), the American Heart Association calls for preventive strategies with particular attention to obesity. The association between obesity and CVD, including coronary artery disease (CAD) and diabetes, is well established. The rising prevalence of obesity in the work... | 25,126,355 | [
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Impact of Treatment by NCQA-Certified Physicians on Diabetes-Related Outcomes. | The National Committee for Quality Assurance supports high-quality care for patients through the Diabetes Recognition Program (DRP). The DRP recognizes physicians and practices that are providing high-quality diabetes care as determined by 10 key measures. To examine the impact of treatment by DRP-certified physicians ... | 25,126,367 | [
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Sensitivity of medication use to formulary controls in medicare beneficiaries: a review of the literature. | Several studies have examined the impact of formulary management strategies on medication use in the elderly, but little has been done to synthesize the findings to determine whether the results show consistent trends. To summarize the effects of formulary controls (ie, tiered copays, step edits, prior authorization, a... | 25,126,370 | [
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Endothelial progenitor cells in cardiovascular diseases. | Endothelial dysfunction has been associated with the development of atherosclerosis and cardiovascular diseases. Adult endothelial progenitor cells (EPCs) are derived from hematopoietic stem cells and are capable of forming new blood vessels through a process of vasculogenesis. There are studies which report correlatio... | 25,126,384 | [
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Biological Targeting of Plasmonic Nanoparticles Improves Cellular Imaging via the Enhanced Scattering in the Aggregates Formed. | Gold nanoparticles (AuNPs) demonstrate great promise in biomedical applications due to their plasmonically enhanced imaging properties. When in close proximity, AuNPs plasmonic fields couple together, increasing their scattering cross-section due to the formation of hot spots, improving their imaging utility. In the pr... | 25,126,388 | [
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Benefits of healthy adipose tissue in the treatment of diabetes. | The major malfunction in diabetes mellitus is severe perturbation of glucose homeostasis caused by deficiency of insulin. Insulin deficiency is either absolute due to destruction or failure of pancreatic β cells, or relative due to decreased sensitivity of peripheral tissues to insulin. The primary lesion being related... | 25,126,390 | [
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Type 2 diabetes and cardiovascular disease: Have all risk factors the same strength? | Diabetes mellitus is a chronic condition that occurs when the body cannot produce enough or effectively use of insulin. Compared with individuals without diabetes, patients with type 2 diabetes mellitus have a considerably higher risk of cardiovascular morbidity and mortality, and are disproportionately affected by car... | 25,126,392 | [
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Domino effect of hypomagnesemia on the innate immunity of Crohn's disease patients. | Digestive diseases play major role in development and complications of other disorders including diabetes. For example, Crohn's disease (CD) is an inflammatory bowel disease associated with Mycobacterium avium subspecies paratuberculosis. The inflammation is a complex process that involves the activity of both innate a... | 25,126,398 | [
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Ocular trauma from the "knockout game". | The "knockout game" is a new form of urban violence receiving much attention in local and national media. Apart from the obvious head trauma, eye injuries may be subtle and overlooked. This report brings awareness of potential eye damage with this type of assault. This report is of a young woman, victim of the knockout... | 25,126,433 | [
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Cecal endometriosis presenting as acute appendicitis. | The aim of our paper is to show the diagnosis of Coecal endometriosis as an infrequent reason of right iliac fossa pain. cecal endometriosis manifesting with right lower quadrant pain is difficult to diagnose, and it may even sometimes require laparotomy for diagnosis and treatment. We report here a case of cecal endom... | 25,126,441 | [
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Zosteriform cutaneous leishmaniasis diagnosed with the help of dermoscopy. | Cutaneous leishmaniasis is usually easy to recognize; however, several atypical features exist, which may pose a diagnostic challenge. Here we report a 55-year-old female patient, who presented with an itchy and painful eruption localized in a dermatomal distribution along the right upper chest. Although the clinical a... | 25,126,460 | [
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Arthroscopic hip labral repair: the iberian suture technique. | Arthroscopic hip labral repair has beneficial short-term outcomes; however, debate exists regarding ideal surgical labral repair technique. This technical note presents an arthroscopic repair technique that uses intrasubstance labral suture passage to restore the chondrolabral interface. This "Iberian suture technique"... | 25,126,502 | [
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Chocolate consumption and prevalence of metabolic syndrome in the NHLBI Family Heart Study. | Previous studies have suggested that cocoa products, which are rich sources of flavonoids, may lower blood pressure, serum cholesterol, fasting blood glucose and improve endothelial function. However, it is unclear whether consumption of cocoa products including chocolate influences the risk of metabolic syndrome (MetS... | 25,126,517 | [
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Formulation and optimization of polymeric nanoparticles for intranasal delivery of lorazepam using Box-Behnken design: in vitro and in vivo evaluation. | The aim of the present study was to optimize lorazepam loaded PLGA nanoparticles (Lzp-PLGA-NPs) by investigating the effect of process variables on the response using Box-Behnken design. Effect of four independent factors, that is, polymer, surfactant, drug, and aqueous/organic ratio, was studied on two dependent respo... | 25,126,544 | [
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Gaining the Upper Hand on Pulmonary Drug Delivery. | Asthma, Chronic Obstructive Pulmonary Disease (COPD) and Cystic Fibrosis (CF) are all pulmonary diseases which are characterized by chronic inflammation and an increase in mucus production. Excess mucus in the airways correlates with pathophysiology such as a decline in lung function and prolonged bacterial infections.... | 25,126,589 | [
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Cytotoxic constituents from the rhizomes of Curcuma zedoaria. | Curcuma zedoaria also known as Temu putih is traditionally used in food preparations and treatment of various ailments including cancer. The cytotoxic activity of hexane, dichloromethane, ethyl acetate, methanol, and the methanol-soxhlet extracts of Curcuma zedoaria rhizomes was tested on two human cancer cell lines (C... | 25,126,594 | [
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Graphs and matroids weighted in a bounded incline algebra. | Firstly, for a graph weighted in a bounded incline algebra (or called a dioid), a longest path problem (LPP, for short) is presented, which can be considered the uniform approach to the famous shortest path problem, the widest path problem, and the most reliable path problem. The solutions for LPP and related algorithm... | 25,126,607 | [
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Treatment planning and dental rehabilitation of a periodontally compromised partially edentulous patient: a case report - Part I. | When planning a prosthetic rehabilitation of a periodontally compromised case, the clinician is often confronted with difficulties and dilemmas related to selecting the appropriate treatment modality that would provide a long-term longevity in terms of function and esthetics. In such cases, a correct diagnosis and prog... | 25,126,619 | [
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Comparison of marginal fit of Lava CAD/CAM crown-copings with two finish lines. | Marginal fit is valued as one of the most important criteria for the clinical quality and success of all-ceramic crowns. The aim of this in vitro study was to investigate the marginal fit of Lava Zirconia crown-copings on chamfer and shoulder preparations. Two acrylic model teeth were selected to simulate the clinical ... | 25,126,621 | [
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Effect of Er,Cr:YSGG laser treatment on microshear bond strength of zirconia to resin cement before and after sintering. | To evaluate the effect of Er,Cr:YSGG laser treatment on microshear bond strength of zirconia to resin cement before and after sintering. Ninety pre-sintered yttrium-stabilized tetragonal zirconia specimens (4 × 3 × 2 mm) were divided into 6 groups (n = 15). In group C, sintered zirconia was not treated (control group).... | 25,126,623 | [
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An idiosyncratic post-traumatic tetrad: compound odontome, dentigerous cyst, impaction, and double-dilaceration. | This report describes the case of a 13-year-old patient who experienced traumatic intrusion of the primary maxillary right central incisor and subsequently suffered an atypical tetrad, comprising of an unerupted compound odontoma associated with a dentigerous cyst, and an impacted, doubly dilacerated permanent maxillar... | 25,126,633 | [
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Rhodium(II)-catalysed tandem aziridination and ring-opening: stereoselective synthesis of functionalised tetrahydrofurans. | Aziridines formed upon treatment of allylic carbamates and homoallylic sulfamates with Rh(II) carboxylate catalysts under oxidative conditions are trapped by suitably-disposed hydroxyl groups to give functionalised tetrahydrofurans. | 25,126,655 | [
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Complementarity of EIS and SPR to reveal specific and nonspecific binding when interrogating a model bioaffinity sensor; perspective offered by plasmonic based EIS. | The present work compares the responses of a model bioaffinity sensor based on a dielectric functionalization layer, in terms of specific and nonspecific binding, when interrogated simultaneously by Surface Plasmon Resonance (SPR), non-Faradaic Electrochemical Impedance Spectroscopy (EIS), and Plasmonic based-EIS (P-EI... | 25,126,676 | [
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Camouflage effects following resin infiltration of postorthodontic white-spot lesions in vivo: One-year follow-up. | To assess camouflage effects by concealment of postorthodontic white-spot lesions (WSLs) to sound adjacent enamel (SAE) achieved over 12 months with resin infiltration (Icon, DMG, Hamburg, Germany). Twenty subjects (trial teeth nteeth = 111) who had received resin infiltration treatment of noncavitated postorthodontic ... | 25,126,675 | [
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Normative sweep frequency impedance measures in healthy neonates. | Diagnosing middle ear disorders in neonates is a challenging task for both audiologists and otolaryngologists. Although high-frequency (1000 Hz) tympanometry and acoustic stapedial reflex tests are useful in diagnosing middle ear problems in this age group, they do not provide information about the dynamics of the midd... | 25,126,682 | [
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Catalyst design in oxidation chemistry; from KMnO4 to artificial metalloenzymes. | Oxidation reactions are an important part of the synthetic organic chemist's toolkit and continued advancements have, in many cases, resulted in high yields and selectivities. This review aims to give an overview of the current state-of-the-art in oxygenation reactions using both chemical and enzymatic processes, the d... | 25,126,712 | [
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Inhibitory effects of p-alkylaminophenol on melanogenesis. | Melanin protects the skin against ultraviolet (UV) rays. It is produced in excess by UV radiation, which causes skin disorders and pigmentation. Retinoic acid (RA) decreases the levels of epidermal melanin by suppressing the expression of melanogenic enzymes including tyrosinase, which is the rate-limiting enzyme in me... | 25,126,713 | [
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[Endovascular versus surgical treatment in subarachnoid haemorrhage: Cost analysis]. | To analyse costs of endovascular versus surgical treatment in 80 patients with aneurysmal subarachnoid haemorrhage (aSAH). We analysed data on 80 consecutive patients with aSAH between January 2010 and June 2011. Endovascular treatment was used in 57 patients and surgical in 23 patients. Demographic (gender and age) an... | 25,126,710 | [
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Mechanical compression insults induce nanoscale changes of membrane-skeleton arrangement which could cause apoptosis and necrosis in dorsal root ganglion neurons. | In a primary spinal cord injury, the amount of mechanical compression insult that the neurons experience is one of the most critical factors in determining the extent of the injury. The ultrastructural changes that neurons undergo when subjected to mechanical compression are largely unknown. In the present study, using... | 25,126,715 | [
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HMGB1-dependent and -independent autophagy. | HMGB1 (high mobility group box 1) is a multifunctional, ubiquitous protein located inside and outside cells that plays a critical role in various physiological and pathological processes including cell development, differentiation, inflammation, immunity, metastasis, metabolism, and death. Increasing evidence demonstra... | 25,126,737 | [
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Positive doping results caused by the single-dose local injection of triamcinolone acetonide. | Triamcinolone acetonide (TA) is classified as an S9 glucocorticoid in the 2014 Prohibited List published by the World Anti-Doping Agency, which caused it to be prohibited in-competition when administered orally, intravenously, intramuscularly or rectally. The Minimum Required Performance Level (MRPL) for the detection ... | 25,126,738 | [
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Single Si nanowire (diameter ≤ 100 nm) based polarization sensitive near-infrared photodetector with ultra-high responsivity. | We report the fabrication and optical response of boron-doped single silicon nanowire-based metal-semiconductor-metal photodetector. Typical single nanowire devices with diameter of ∼80-100 nm and electrode spacing of ∼1 μm were made using electron-beam lithography from nanowires, grown by a metal-assisted chemical etc... | 25,126,742 | [
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Prevalence and predictors of mental disorders in intentionally and unintentionally injured emergency center patients. | Little is known about the prevalence and predictors of mental disorders among injured emergency center (EC) patients in low- and middle-income countries (LMICs). Patients presenting with either an intentional or unintentional injury were recruited (N = 200). Mental health, injury, and psychological trauma histories wer... | 25,126,754 | [
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Lights, X-rays, oxygen! | Photosystem II uses metal ions to oxidize water to form O2. Two recent papers employ the new technique of serial femtosecond crystallography utilizing X-ray free-electron lasers and nanocrystals to obtain initial structures of intermediate states of photosystem II catalysis at the site of oxygen production. | 25,126,779 | [
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Regulation of insulin sensitivity by adiponectin and its receptors in response to physical exercise. | Adiponectin is an adipocyte-derived abundant plasma protein, also called Acrp30 (adipocyte complement-related protein), adipoQ, ApM1 (AdiPose Most abundant Gene transcript 1), or GBP28 (gelatin-binding protein-28). Insulin resistance is a primary contributing factor in the pathogenesis of type 2 diabetes. Adiponectin b... | 25,126,860 | [
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The effect of a sexuality education programme among out- of- school adolescents in Lagos, Nigeria. | This study was conducted to assess the effect of a community based sexuality education programme on the sexual health knowledge and practices of out of school female adolescents. This Intervention study was conducted in two markets within Lagos, Nigeria. Representative samples of adolescents were interviewed on their s... | 25,126,865 | [
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0.0137807... |
Chiral gold nanowires with Boerdijk-Coxeter-Bernal structure. | A Boerdijk-Coxeter-Bernal (BCB) helix is made of linearly stacked regular tetrahedra (tetrahelix). As such, it is chiral without nontrivial translational or rotational symmetries. We demonstrate here an example of the chiral BCB structure made of totally symmetrical gold atoms, created in nanowires by direct chemical s... | 25,126,894 | [
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Size-resolved deposition rates for ultrafine and submicrometer particles in a residential housing unit. | We estimated the size-resolved particle deposition rates for the ultrafine and submicrometer particles using a nonlinear regression method with unknown particle background concentrations during nonsourced period following a controlled sourced period in a well-mixed residential environment. A dynamic adjustment method i... | 25,126,897 | [
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Single-photon transistor using a Förster resonance. | An all-optical transistor is a device in which a gate light pulse switches the transmission of a target light pulse with a gain above unity. The gain quantifies the change of the transmitted target photon number per incoming gate photon. We study the quantum limit of one incoming gate photon and observe a gain of 20. T... | 25,126,919 | [
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0.0477561,
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Beam-energy dependence of charge separation along the magnetic field in Au+Au collisions at RHIC. | Local parity-odd domains are theorized to form inside a quark-gluon plasma which has been produced in high-energy heavy-ion collisions. The local parity-odd domains manifest themselves as charge separation along the magnetic field axis via the chiral magnetic effect. The experimental observation of charge separation ha... | 25,126,911 | [
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Time-reversal-symmetry breaking in turbulence. | In three-dimensional turbulent flows, the flux of energy from large to small scales breaks time symmetry. We show here that this irreversibility can be quantified by following the relative motion of several Lagrangian tracers. We find by analytical calculation, numerical analysis, and experimental observation that the ... | 25,126,923 | [
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Brain networks during free viewing of complex erotic movie: new insights on psychogenic erectile dysfunction. | Psychogenic erectile dysfunction (ED) is defined as a male sexual dysfunction characterized by a persistent or recurrent inability to attain adequate penile erection due predominantly or exclusively to psychological or interpersonal factors. Previous fMRI studies were based on the common occurrence in the male sexual b... | 25,126,947 | [
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A double-blind, placebo-controlled trial related to the effects of melatonin on oxidative stress and inflammatory parameters of obese women. | Obesity, the global epidemic health problem, results in chronic disorders. Melatonin supplementation may prevent the adverse health consequences of obesity. The aim of this study was to assess the effects of melatonin supplementation on inflammatory and oxidative stress parameters in obese women. In randomized, double-... | 25,126,957 | [
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Comprehensive approach to systemic sclerosis patients during pregnancy. | Systemic sclerosis (SSc) is a connective tissue disease that usually affects women, with a male:female ratio of 1:4-10. It was thought that there was a prohibitive risk of fatal complications in the pregnancies of patients with SSc. It is now known that the majority of these women undergo a normal progression of pregna... | 25,126,963 | [
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A pharmacogenetics-based warfarin maintenance dosing algorithm from Northern Chinese patients. | Inconsistent associations with warfarin dose were observed in genetic variants except VKORC1 haplotype and CYP2C9*3 in Chinese people, and few studies on warfarin dose algorithm was performed in a large Chinese Han population lived in Northern China. Of 787 consenting patients with heart-valve replacements who were rec... | 25,126,975 | [
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Environmental sampling for Clostridium difficile on alcohol-based hand rub dispensers in an academic medical center. | Clostridum difficile is a gram-positive, spore-forming anaerobic bacillus that has substantial associated morbidity, mortality, and associated healthcare burdens. Clostridium difficile spores are not destroyed by alcohol. Alcohol gel dispensers are used commonly as the hand sanitization method of choice in hospitals. I... | 25,126,976 | [
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Activating PI3-kinase to dampen inflammation. | Diterpene derivatives of the natural product acanthoic acid have potent anti-inflammatory effects in vivo. In this issue of Chemistry & Biolgy, Través and colleagues report that the primary molecular mechanism of action of diterpenes structurally related to acanthoic acid is the direct activation of PI3-kinase sign... | 25,126,986 | [
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Rehabilitating mutant GCase. | Gaucher's disease is a hereditary deficiency of the enzyme β-glucocerebrosidase (GCase) that is most commonly treated by enzyme replacement therapy. In this issue of Chemistry & Biology, Tan and colleagues search for alternative ways to rehabilitate mutant GCase by understanding how it interacts with the proteostas... | 25,126,987 | [
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ERdj3 is an endoplasmic reticulum degradation factor for mutant glucocerebrosidase variants linked to Gaucher's disease. | Gaucher's disease (GD) is caused by mutations that compromise β-glucocerebrosidase (GCase) folding in the endoplasmic reticulum (ER), leading to excessive degradation instead of trafficking, which results in insufficient lysosomal function. We hypothesized that ER GCase interacting proteins play critical roles in makin... | 25,126,989 | [
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Synthesis of antifungal vaccines by conjugation of β-1,2 trimannosides with T-cell peptides and covalent anchoring of neoglycopeptide to tetanus toxoid. | Selective strategies for the construction of novel three component glycoconjugate vaccines presenting Candida albicans cell wall glycan (β-1,2 mannoside) and polypeptide fragments on a tetanus toxoid carrier are described. The first of two conjugation strategies employed peptides bearing an N-terminal thiopropionyl res... | 25,126,994 | [
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-... |
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