title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Safety and tolerability of zonisamide in paediatric patients with epilepsy. | Zonisamide has recently been approved in Europe for the adjunctive treatment of partial seizures (with or without secondary generalisation) in adolescents and children aged ≥6 years. To further assess the safety of adjunctive zonisamide in paediatric epilepsy patients. A pooled analysis of data from 17 studies (includi... | 25,128,350 | [
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Application and assessment of optical clearing methods for imaging of tissue-engineered neural stem cell spheres. | Three-dimensional (3D) cell culture is an important tool that facilitates biological discoveries by bridging the divide between standard two-dimensional cell culture and the complex, high-cell-density in vivo environment. Typically, the internal structures of 3D tissue-engineered samples are visualized through an invol... | 25,128,373 | [
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siRNA therapy in cutaneous T-cell lymphoma cells using polymeric carriers. | Cutaneous T-cell lymphomas (CTCLs) arise from specific molecular aberrations that lead to uncontrolled cell proliferation. RNA interference (RNAi) with short interfering RNAs (siRNAs) is a feasible approach to interrupt aberrant signal processing in CTCL cells, but functional biomaterial carriers are needed to effectiv... | 25,128,374 | [
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Radiodense ligament markers for radiographic evaluation of anterior cruciate ligament reconstruction. | Early clinical and radiographic diagnosis of failed or loosened anterior cruciate ligament (ACL) reconstructions can be challenging. The aim of the present study is to retrospectively evaluate the use of radiologically visible markers in the ACL graft, serving as a potential diagnostic tool in ACL graft rupture and ins... | 25,128,383 | [
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Coronal tibiofemoral subluxation: a new measurement method. | Coronal tibiofemoral (CTF) subluxation is a common finding in knee osteoarthritis (OA) which can be related to poor pain scores and tibial spine impingement. In this study we describe a new method for measuring CTF subluxation and present validation of the method using cadaveric knees. A prototype software code based o... | 25,128,384 | [
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[Certification system in urological healthcare : a professional political evaluation]. | There have been function and organ-related certification systems in urology for a long time. The aim of such certificates is the optimization of patient care above the defined minimum standards and intensification of interdisciplinary cooperation. Whether such certificates have led to better patient care has not been p... | 25,128,395 | [
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Increased intrathoracic and hepatic visceral adipose tissue independently correlates with coronary artery calcification in asymptomatic patients. | Visceral adipose tissue (VAT) is associated with cardiac events, but it is not clear which, if any of the various measures of VAT independently correlate with coronary artery disease (CAD). We studied 400 patients undergoing computed tomography to determine coronary artery calcium (CAC) score. VAT was measured in the f... | 25,128,404 | [
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Penialidins A-C with strong antibacterial activities from Penicillium sp., an endophytic fungus harboring leaves of Garcinia nobilis. | Three new polyketides named penialidins A-C (1-3), along with one known compound, citromycetin (4), were isolated from an endophytic fungus, Penicillium sp., harbored in the leaves of the Cameroonian medicinal plant Garcinia nobilis. Their structures were elucidated by means of spectroscopic and spectrometric methods (... | 25,128,427 | [
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Love-Hate ligands for high resolution analysis of strain in ultra-stable protein/small molecule interaction. | The pathway of ligand dissociation and how binding sites respond to force are not well understood for any macromolecule. Force effects on biological receptors have been studied through simulation or force spectroscopy, but not by high resolution structural experiments. To investigate this challenge, we took advantage o... | 25,128,469 | [
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Familial acute necrotizing encephalopathy due to mutation in the RANBP2 gene. | Acute necrotizing encephalopathy (ANE) is a rare and severe parainfectious central nervous system disease in which previously healthy children develop rapidly progressive coma following viral illness. While most ANE are sporadic, familial autosomal dominant ANE due to mutations in the RANBP2 gene has been recently repo... | 25,128,471 | [
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Ceftazidime-avibactam and comparator agents tested against urinary tract isolates from a global surveillance program (2011). | Ceftazidime-avibactam, a combination of ceftazidime and the non-β-lactam β-lactamase inhibitor avibactam, is in advanced clinical development. In this study, we report results of in vitro testing of ceftazidime-avibactam and comparator agents against a collection of urinary tract infection (UTI) isolates from the Unite... | 25,128,477 | [
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Unfractionated heparin and placental pathology in high-risk pregnancies: secondary analysis of a pilot randomized controlled trial. | Heparin is often prescribed during pregnancy with the intention of improving perinatal outcomes on the basis that it exerts an anticoagulant action in the inter-villous space. Accumulating in-vitro and in-vivo evidence indicates that heparin's beneficial effects in pregnancy may result from 'non-anticoagulant' effects ... | 25,128,485 | [
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Tocilizumab treatment increases left ventricular ejection fraction and decreases left ventricular mass index in patients with rheumatoid arthritis without cardiac symptoms: assessed using 3.0 tesla cardiac magnetic resonance imaging. | The aim of our pilot study was to prospectively evaluate the effect of inhibiting interleukin 6 on the left ventricular (LV) structure and function in patients with rheumatoid arthritis (RA) without cardiac symptoms, using cardiac magnetic resonance (CMR). Female patients with RA with active disease and healthy control... | 25,128,513 | [
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Structural and mechanistic insight into the Listeria monocytogenes two-enzyme lipoteichoic acid synthesis system. | Lipoteichoic acid (LTA) is an important cell wall component required for proper cell growth in many Gram-positive bacteria. In Listeria monocytogenes, two enzymes are required for the synthesis of this polyglycerolphosphate polymer. The LTA primase LtaP(Lm) initiates LTA synthesis by transferring the first glycerolphos... | 25,128,528 | [
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Retrieval is not necessary to trigger reconsolidation of object recognition memory in the perirhinal cortex. | Memory retrieval has been considered as requisite to initiate memory reconsolidation; however, some studies indicate that blocking retrieval does not prevent memory from undergoing reconsolidation. Since N-methyl-D-aspartate (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptors in t... | 25,128,536 | [
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The role of mitotic kinases in coupling the centrosome cycle with the assembly of the mitotic spindle. | The centrosome acts as the major microtubule-organizing center (MTOC) for cytoskeleton maintenance in interphase and mitotic spindle assembly in vertebrate cells. It duplicates only once per cell cycle in a highly spatiotemporally regulated manner. When the cell undergoes mitosis, the duplicated centrosomes separate to... | 25,128,564 | [
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Local edge statistics provide information regarding occlusion and nonocclusion edges in natural scenes. | Edges in natural scenes can result from a number of different causes. In this study, we investigated the statistical differences between edges arising from occlusions and nonocclusions (reflectance differences, surface change, and cast shadows). In the first experiment, edges in natural scenes were identified using the... | 25,128,569 | [
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Resistance to HIV integrase strand transfer inhibitors: in vitro findings and clinical consequences. | Three integrase strand transfer inhibitors have now been approved for the treatment of HIV infection, raltegravir, cobicistat-boosted elvitegravir, and dolutegravir. Each of these agents selects for unique signature mutations; however, there can be significant cross resistance among all three drugs when multiple mutati... | 25,128,610 | [
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Autotransporter mediated esterase display on Zymomonas mobilis and Zymobacter palmae. | Autodisplay, i.e. surface expression of recombinant proteins by virtue of the autotransporter secretion pathway, has been used predominantly with Escherichia coli as host organism, which often limits the applicability of this technique to laboratory purposes and scales. The aim of this study was to investigate if the f... | 25,128,612 | [
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Chromatin regulation of DNA damage repair and genome integrity in the central nervous system. | With the continued extension of lifespan, aging and age-related diseases have become a major medical challenge to our society. Aging is accompanied by changes in multiple systems. Among these, the aging process in the central nervous system is critically important but very poorly understood. Neurons, as post-mitotic ce... | 25,128,619 | [
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Brain-derived neurotrophic factor immunoreactive vagal sensory neurons innervating the gastrointestinal tract of the rat. | We have determined whether brain-derived neurotrophic factor immunoreactive (BDNF-ir) neurons in the vagal ganglia innervate the gastrointestinal tract. Many BDNF-ir neurons were medium in size and located throughout the jugular and nodose ganglia. When Fluorogold was injected into the wall of the cervical esophagus, m... | 25,128,629 | [
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Assessment of endosulfan induced genotoxicity and mutagenicity manifested by oxidative stress pathways in freshwater cyprinid fish crucian carp (Carassius carassius L.). | Over the past few decades, endosulfan, one of the polychlorinated pesticides still in use, has received considerable attention of a number of international regulations and restriction action plans worldwide. This study aimed to evaluate the cytogenetic effects of endosulfan using robust genotoxicity assays, along with ... | 25,128,633 | [
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The effect of chronic low back pain on tactile suppression during back movements. | The aim of the present study was to examine whether tactile suppression, the phenomenon whereby tactile perception is suppressed during movement, would occur in the context of back movements. Of particular interest, it was investigated if tactile suppression in the back would be attenuated in those suffering from chron... | 25,128,642 | [
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Embelin inhibits pancreatic cancer progression by directly inducing cancer cell apoptosis and indirectly restricting IL-6 associated inflammatory and immune suppressive cells. | Pancreatic cancer is an aggressive malignancy and unresponsive to conventional chemotherapies. Here, the anti-inflammatory and anti-tumor effects of embelin on pancreatic cancer were investigated. Embelin significantly attenuated cells invasion, proliferation and induced apoptosis through inhibition of STAT3 and activa... | 25,128,650 | [
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A model for enhanced and selective transport through biological membranes with alternating pores. | We investigate the outflux of ions through the channels in a cell membrane. The channels undergo an open/close cycle according to a periodic schedule. Our study is based both on theoretical considerations relying on homogenization theory, and on Monte Carlo numerical simulations. We examine the onset of a limiting boun... | 25,128,658 | [
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Mode of membrane insertion of individual transmembrane segments in Mdl1 and Mdl2, multi-spanning mitochondrial ABC transporters. | The sorting of an individual transmembrane (TM) segment of multi-spanning membrane proteins by the TIM23 complex in the mitochondrial inner membrane is poorly understood. Using the Mgm1 fusion approach, we attempted to assess the membrane insertion of individual TM segments of Mdl1p and Mdl2p, mitochondrial ABC transpo... | 25,128,661 | [
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Toxoplasma gondii and Neospora caninum infections in goat abortions from Argentina. | The aims of this study were to identify the occurrence of Toxoplasma gondii and Neospora caninum abortions in goats from Argentina by serological, macroscopical and microscopical examination and bioassay, and to characterize the obtained isolates by molecular techniques. For this purpose, 25 caprine fetal fluids, 18 ca... | 25,128,663 | [
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Racial/ethnic disparities in mental health over the first 2 years after traumatic brain injury: a model systems study. | To determine whether racial/ethnic disparities occur in depression, anxiety, and satisfaction with life at 1 and 2 years postdischarge. A prospective, longitudinal, multicenter study of individuals with traumatic brain injury (TBI) participating in the National Institute on Disability and Rehabilitation Research Trauma... | 25,128,715 | [
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The mitochondrial genome of Frankliniella intonsa: insights into the evolution of mitochondrial genomes at lower taxonomic levels in Thysanoptera. | Thrips is an ideal group for studying the evolution of mitochondrial (mt) genomes in the genus and family due to independent rearrangements within this order. The complete sequence of the mitochondrial DNA (mtDNA) of the flower thrips Frankliniella intonsa has been completed and annotated in this study. The circular ge... | 25,128,725 | [
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Recurrent respiratory distress and cardiopulmonary arrest caused by megaoesophagus secondary to achalasia. | Respiratory distress and arrest from tracheal compression secondary to megaoesophagus are rare complications of achalasia. We present the case of a man with end-stage achalasia who required oesophagectomy to prevent recurrent life-threatening tracheal compression and respiratory arrest. A literature review is also pres... | 25,128,729 | [
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Can pelvic tilting be ignored in total hip arthroplasty? | The orientation of acetabular component is influenced by pelvic tilt, body position and individual variation in pelvic parameters. Most post-operative adverse events may be attributed to malposition of the component in the functional position. There is evidence that orientation of the pelvis changes from the supine to ... | 25,128,730 | [
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Interactome analyses of Salmonella pathogenicity islands reveal SicA indispensable for virulence. | Serovars of Salmonella enterica, namely Typhi and Typhimurium, reportedly, are the bacterial pathogens causing systemic infections like gastroenteritis and typhoid fever. To elucidate the role and importance in such infection, the proteins of the Type III secretion system of Salmonella pathogenicity islands and two com... | 25,128,737 | [
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A framework for monitoring social process and outcomes in environmental programs. | When environmental programs frame their activities as being in the service of human wellbeing, social variables need to be integrated into monitoring and evaluation (M&E) frameworks. This article draws upon ecosystem services theory to develop a framework to guide the M&E of collaborative environmental programs... | 25,128,755 | [
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Virus-host mucosal interactions during early SIV rectal transmission. | To deepen our understanding of early rectal transmission of HIV-1, we studied virus-host interactions in the rectal mucosa using simian immunodeficiency virus (SIV)-Indian rhesus macaque model and mRNA deep sequencing. We found that rectal mucosa actively responded to SIV as early as 3 days post-rectal inoculation (dpi... | 25,128,762 | [
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Protective effect of naringenin against gentamicin-induced nephrotoxicity in rats. | The protective effect of naringenin, a flavonoid compound isolated from citrus fruits, was investigated against nephrotoxicity induced by gentamicin (80mgkg(-1)/day, i.p., for eight days) in rats. Naringenin treatment (50mgkg(-1)/day, p.o.) was administered for eight days, starting on the same day of gentamicin adminis... | 25,128,772 | [
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Geochemical and grain-size distribution of radioactive and stable cesium in Fukushima soils: implications for their long-term behavior. | Availability and mobility of radioactive cesium, (137)Cs, in soils are crucial for recovery from the accident in the Fukushima Dai-ichi Nuclear Power Plants. In this study we investigated the geochemical and grain-size distribution of (137)Cs in 11 soil samples collected in the eastern area of Fukushima Prefecture afte... | 25,128,773 | [
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Development of a model using the MATLAB System identification toolbox to estimate (222)Rn equilibrium factor from CR-39 based passive measurements. | Can and Bare method is a widely used passive method for measuring the equilibrium factor F through the determination of the track density ratio between bare (D) and filtered (Do) detectors. The dimensions of the used diffusion chamber are altering the deposition ratios of Po-isotopes on the chamber walls as well as the... | 25,128,775 | [
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Modulation of dendritic cell antigen presentation by pathogens, tissue damage and secondary inflammatory signals. | Antigen presentation by dendritic cells (DC) is regulated directly by pathogen-associated or cell death-associated cues, or indirectly by immunomodulatory molecules produced during infection or tissue damage. DC modulation by direct encounter of pathogen-associated compounds has been thoroughly studied; the effects of ... | 25,128,781 | [
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Intranasal seasonal influenza vaccine and a TLR-3 agonist, rintatolimod, induced cross-reactive IgA antibody formation against avian H5N1 and H7N9 influenza HA in humans. | The intranasal use of rintatolimod, a specific TLR-3 agonist, combined with trivalent seasonal influenza vaccine generated cross-protection against highly pathogenic H5N1 avian influenza in mice. The purpose of this clinical trial is to assess the safety and impact of rintatolimod on intranasal influenza vaccine in hea... | 25,128,802 | [
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Raf/MEK/ERK can regulate cellular levels of LC3B and SQSTM1/p62 at expression levels. | While cellular LC3B and SQSTM1 levels serve as key autophagy markers, their regulation by different signaling pathways requires better understanding. Here, we report the mechanisms by which the Raf/MEK/ERK pathway regulates cellular LC3B and SQSTM1 levels. In different cell types, ΔRaf-1:ER- or B-Raf(V600E)-mediated ME... | 25,128,814 | [
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Identification of a telomeric DNA-binding protein in Eimeria tenella. | Coccidiosis is considered to be a major problem for the poultry industry, and coccidiosis control is yet urgent. Due to the roles in telomere length regulation and end protection, telomere-binding proteins have been considered as a good target for drug design. In this work, a putative Gbp1p that is similar to telomeric... | 25,128,826 | [
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Fractal microstructure characterization of wet microalgal cells disrupted with ultrasonic cavitation for lipid extraction. | The effects of ultrasonic treatment on fractal microstructures of wet microalgal cells were investigated for lipid extraction. Fractal dimension of cells with distorted surfaces increased with power and ultrasonication time. Microalgal cells shrank owing to dehydration and cytomembranes were reduced to debris, but cell... | 25,128,843 | [
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Spinal administration of mGluR5 antagonist prevents the onset of bortezomib induced neuropathic pain in rat. | Peripheral neuropathy is a common adverse effect of bortezomib-based chemotherapy. In this study we have investigated the role played by subtype 5 of metabotropic receptors in bortezomib induced peripheral neuropathy. Rats were administered with bortezomib three times weekly at 0.20 mg/kg for a total of 4 weeks in pres... | 25,128,849 | [
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Expression of biologically active TAT-fused recombinant islet transcription factors. | Differentiation of pancreatic endocrine cells depends upon the activation of genes that are regulated by islet transcription factors (ITFs). Evidence suggests that ITFs contribute to the development of the pancreas. These studies are focused on developing a system to deliver individual ITF from different stages of isle... | 25,128,855 | [
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A simple LC-MS/MS method for determination of sitafloxacin in human urine. | Sitafloxacin is a new fluoroquinolone antimicrobial agent with high activity. In this article, we reported a simple, rapid and specific LC-MS/MS method for accurate determination of sitafloxacin concentrations in human urine from healthy volunteers in detail. A two-step dilution method for the analysis of sitafloxacin ... | 25,128,880 | [
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Geographical distribution of human Schistosoma japonicum infection in The Philippines: tools to support disease control and further elimination. | Schistosoma japonicum infection is believed to be endemic in 28 of the 80 provinces of The Philippines and the most recent data on schistosomiasis prevalence have shown considerable variability between provinces. In order to increase the efficient allocation of parasitic disease control resources in the country, we aim... | 25,128,879 | [
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Stereoselective quantitation of haloxyfop in environment samples and enantioselective degradation in soils. | The chiral separation of haloxyfop enantiomers was first performed on (R, R) Whelk-O1 chiral column (pirkle type) by high-performance liquid chromatography (HPLC). Chromatographic conditions such as mobile phase composition and column temperature were optimized, and the best resolution was obtained using hexane/n-propa... | 25,128,890 | [
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A dorsal-pathway account of aphasic language production: the WEAVER++/ARC model. | It has long been assumed that a dorsal pathway running from temporal to inferior frontal cortex underpinned by the left arcuate fasciculus (AF) underlies both repetition and spoken language production. However, according to a recent proposal, a ventral pathway underpinned by extreme capsule (EmC) and uncinate fasciculu... | 25,128,898 | [
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Management of outpatients in France with stable coronary artery disease. Findings from the prospeCtive observational LongitudinAl RegIstry oF patients with stable coronary arterY disease (CLARIFY) registry. | Improvements in the treatment of coronary artery disease mean that an increasing number of patients survive acute cardiovascular events and live as outpatients with or without anginal symptoms. To determine the characteristics and management of contemporary outpatients with stable coronary artery disease in Western Eur... | 25,128,934 | [
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Impact of high-sensitivity cardiac troponin I assays on patients presenting to an emergency department with suspected acute coronary syndrome. | To determine whether introduction of high-sensitivity cardiac troponin I (hscTn-I) assays affected management of patients presenting with suspected acute coronary syndrome (ACS) to the emergency department (ED) of a tertiary referral hospital. A retrospective analysis of all patients presenting to the Geelong Hospital ... | 25,128,951 | [
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Respondent driven sampling is an effective method for engaging methamphetamine users in HIV prevention research in South Africa. | South Africa, in the midst of the world's largest HIV epidemic, has a growing methamphetamine problem. Respondent driven sampling (RDS) is a useful tool for recruiting hard-to-reach populations in HIV prevention research, but its use with methamphetamine smokers in South Africa has not been described. This study examin... | 25,128,957 | [
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Accurate de novo and transmitted indel detection in exome-capture data using microassembly. | We present an open-source algorithm, Scalpel (http://scalpel.sourceforge.net/), which combines mapping and assembly for sensitive and specific discovery of insertions and deletions (indels) in exome-capture data. A detailed repeat analysis coupled with a self-tuning k-mer strategy allows Scalpel to outperform other sta... | 25,128,977 | [
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The molecular symplesiomorphies shared by the stem groups of metazoan evolution: can sites as few as 1% have a significant impact on recognizing the phylogenetic position of myzostomida? | Although it is clear that taxon sampling, alignments, gene sampling, tree reconstruction methods and the total length of the sequences used are critical to the reconstruction of evolutionary history, weakly supported or misleading nodes exist in phylogenetic studies with no obvious flaw in those aspects. The phylogenet... | 25,128,981 | [
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Resistance to nucleotide analogue inhibitors of hepatitis C virus NS5B: mechanisms and clinical relevance. | The high barrier to the development of resistance to nucleotide analogue inhibitors of the hepatitis C virus (HCV) RNA-dependent RNA polymerase is an intriguing property of this class of drugs. The S282T substitution in the viral polymerase confers resistance to 2'-C-methylated nucleotide analogues. Although this mutat... | 25,128,987 | [
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... |
Extracorporeal membrane oxygenation in adults for severe acute respiratory failure. | The purpose of this review is to examine the indications of extracorporeal membrane oxygenation (ECMO) for severe acute respiratory distress syndrome (ARDS). This technique of oxygenation has significantly increased worldwide with the H1N1 flu pandemic. The goal of ECMO is to maintain a safe level of oxygenation and co... | 25,128,980 | [
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Multicystic dysplastic kidney: a retrospective study. | To report the renal structural and functional anomalies in children with multicystic dysplastic kidneys. Retrospective descriptive analysis of 47 children with multicystic dysplastic kidney seen in a pediatric nephrology unit over a period of 6 years. Antenatal diagnosis of multicystic dysplastic kidney was made in 34 ... | 25,128,997 | [
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An automatic tool to facilitate the statistical group analysis of DTI. | Users may have difficulty calculating DTI group statistics since they need to master several complex tools that require high user intervention. A tool called DTIStatistics for the automatic and easy calculation of DTI group statistics was developed to reduce analysis times and possible errors. The proposed software was... | 25,129,019 | [
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A computational pipeline for quantification of mouse myocardial stiffness parameters. | The mouse is an important model for theoretical-experimental cardiac research, and biophysically based whole organ models of the mouse heart are now within reach. However, the passive material properties of mouse myocardium have not been much studied. We present an experimental setup and associated computational pipeli... | 25,129,018 | [
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Assessment of the mechanical properties of ProTaper Next Nickel-titanium rotary files. | The purpose of this study was to compare the torsional resistance, flexibility, and surface microhardness of ProTaper Next files (PTN) with Twisted Files (TF) and RaCe (RC). A metal block with a cubical hole was used to evaluate the torsional resistance. Five millimeters of the tip of each file was securely held in pla... | 25,129,026 | [
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A chemical inhibitor of jasmonate signaling targets JAR1 in Arabidopsis thaliana. | Jasmonates are lipid-derived plant hormones that regulate plant defenses and numerous developmental processes. Although the biosynthesis and molecular function of the most active form of the hormone, (+)-7-iso-jasmonoyl-L-isoleucine (JA-Ile), have been unraveled, it remains poorly understood how the diversity of bioact... | 25,129,030 | [
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Detergent-compatible bacterial amylases. | Proteases, lipases, amylases, and cellulases are enzymes used in detergent formulation to improve the detergency. The amylases are specifically supplemented to the detergent to digest starchy stains. Most of the solid and liquid detergents that are currently manufactured contain alkaline enzymes. The advantages of usin... | 25,129,040 | [
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Turning the spotlight on protein-lipid interactions in cells. | Protein function is largely dependent on coordinated and dynamic interactions of the protein with biomolecules including other proteins, nucleic acids and lipids. Although powerful methods for global profiling of protein-protein and protein-nucleic acid interactions are available, proteome-wide mapping of protein-lipid... | 25,129,056 | [
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The role of mitochondrial reactive oxygen species in cartilage matrix destruction. | Upregulation of matrix metalloproteinases (MMPs) is a hallmark of osteoarthritis progression; along with the role reactive oxygen species (ROS) may play in this process. Moreover, mitochondrial DNA damage and dysfunction are also present in osteoarthritic chondrocytes. However, there are no studies published investigat... | 25,129,057 | [
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Comparison of safety of sotalol versus amiodarone in patients with atrial fibrillation and coronary artery disease. | Sotalol is a commonly prescribed antiarrhythmic drug (AAD) used for maintaining sinus rhythm in patients with atrial fibrillation (AF). Although randomized studies have found that sotalol can significantly delay time to AF recurrence, its association with mortality is less clear, particularly among those with coronary ... | 25,129,065 | [
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Age-related change in sit-to-stand power in Japanese women aged 50 years or older. | This study examined whether the age-related change in power, calculated from the score of a sit-to-stand (STS) test, corresponds to those in knee extension torque and leg lean tissue mass in Japanese women aged 50 years or older. Time for a 10-times-repeated STS test and knee extension torque were determined in 556 Jap... | 25,129,071 | [
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0.02273044,
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The GABAergic parafacial zone is a medullary slow wave sleep-promoting center. | Work in animals and humans has suggested the existence of a slow wave sleep (SWS)-promoting/electroencephalogram (EEG)-synchronizing center in the mammalian lower brainstem. Although sleep-active GABAergic neurons in the medullary parafacial zone (PZ) are needed for normal SWS, it remains unclear whether these neurons ... | 25,129,078 | [
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[Overview of guidelines for proper use of the G-CSF(2013 edition)]. | Guidelines for proper use of the G-CSF(2001 edition)by the Japan Society of Clinical Oncology have been revised the first time in 12 years. The differences between the first edition and the new one are as follows: The new guidelines(2013 edition) adopted the clinical question format, and used the level of evidence and ... | 25,129,080 | [
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[Use of granulocyte-colony stimulating factor(G-CSF)in patients with cancer at high risk of febrile neutropenia on the basis of high age and complications, recommendations for patients receiving radiotherapy, and adverse events because of G-CSF]. | Neutropenic complications are the primary dose-limiting toxic effects observed in patients treated with systemic cancer chemotherapy. Broad-spectrum antibiotic therapy should be promptly administered to patients with febrile neutropenia(FN). The risk assessment of FN includes the disease characteristics, chemotherapy r... | 25,129,083 | [
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... |
[Neuroendocrine gallbladder cancer treated with cisplatin plus irinotecan - a case report]. | A 52-year-old woman was referred to our hospital because of upper abdominal pain. A computed tomography(CT)scan revealed bulky gallbladder and liver tumors. We reached a tentative diagnosis of invasive adenocarcinoma of the gallbladder and performed needle biopsy of the tumor. Biopsied specimens showed the proliferatio... | 25,129,091 | [
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[A case report of primary adenocarcinoma of the small intestine with peritoneal dissemination treated with multidisciplinary therapy]. | A 55-year-old woman consulted our hospital complaining of abdominal distention and vomiting. She was diagnosed with a malignant tumor in the small intestine and an ovarian tumor with an upper gastro-intestinal series based on a computerized tomography(CT)examination. Intra-operative findings showed that the primary tum... | 25,129,097 | [
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0.4725854,
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Microvascular lesions by estrogen-induced ID3: its implications in cerebral and cardiorenal vascular disease. | Severe symptoms of cerebral and cardiorenal vascular diseases can be triggered when cerebral, coronary, or glomerular arterioles grow inappropriately as a result of abnormal cell proliferation. The risk factor(s) and molecular mechanisms responsible for microvascular lesion formation are largely unknown. Although contr... | 25,129,100 | [
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Role of thromboelastography and rapid thromboelastography to assess the pharmacodynamic effects of vitamin K antagonists. | Thromboelastography (TEG) measures the effects of antithrombotic agents by assessing global functional clotting status by evaluating the viscoelastic properties of in vitro clot formation. Recently, rapid TEG (r-TEG), which uses tissue factor in addition to standard kaolin to accelerate activation of the clotting casca... | 25,129,122 | [
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High-density genetic linkage map construction and identification of fruit-related QTLs in pear using SNP and SSR markers. | Pear (Pyrus spp) is an important fruit crop, grown in all temperate regions of the world, with global production ranked after grape and apples among deciduous tree crops. A high-density linkage map is a valuable tool for fine mapping quantitative trait loci (QTL) and map-based gene cloning. In this study, we firstly co... | 25,129,128 | [
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Insights into transcriptional regulation of β-D-N-acetylhexosaminidase, an N-glycan-processing enzyme involved in ripening-associated fruit softening. | Tomato (Solanum lycopersicum) fruit ripening-specific N-glycan processing enzyme, β-D-N-acetylhexosaminidase (β-Hex), plays an important role in the ripening-associated fruit-softening process. However, the regulation of fruit ripening-specific expression of β-Hex is not well understood. We have identified and function... | 25,129,131 | [
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Results of a comparative study analyzing octogenarians with renal cell carcinoma in a competing risk analysis with patients in the seventh decade of life. | To analyze clinicopathological features and survival of surgically treated patients with renal cell carcinoma (RCC) ≥ 80 years of age in comparison with patients between the ages of 60 and 70 years. The data for 2,516 patients with a median follow-up of 57 months were retrieved from a multinational database (Collaborat... | 25,129,141 | [
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JAGN1 deficiency causes aberrant myeloid cell homeostasis and congenital neutropenia. | The analysis of individuals with severe congenital neutropenia (SCN) may shed light on the delicate balance of factors controlling the differentiation, maintenance and decay of neutrophils. We identify 9 distinct homozygous mutations in the JAGN1 gene encoding Jagunal homolog 1 in 14 individuals with SCN. JAGN1-mutant ... | 25,129,144 | [
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Atmospheric pollutants in fog and rain events at the northwestern mountains of the Iberian Peninsula. | Atmospheric polycyclic aromatic hydrocarbons (PAHs) and polychlorinated biphenyls (PCBs) are persistent organic pollutants (POPs) and exist in gas and particle phases, as well as dissolved or suspended in precipitation (fog or rain). While the hydrosphere is the main reservoir for PAHs, the atmosphere serves as the pri... | 25,129,155 | [
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Accumulation and elimination of polychlorinated dibenzo-p-dioxins and dibenzofurans in mule ducks. | In Taiwan, a food safety crisis involving a presence of high concentrations of dioxin residues in duck eggs occurred in 2004. The dioxin content in duck meat sampled from supermarkets was also reported to be substantially higher than in products from other farm animals. Despite increased awareness of the potential for ... | 25,129,161 | [
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Effects of hyperandrogenism and high body mass index on acne severity in women. | To determine the association between hyperandrogenism and obesity with acne, and correlation between the severity of acne with the clinical and laboratory parameters of hyperandrogenism. One hundred and forty-one female with acne vulgaris and 73 healthy women were included in this study. The correlation of clinical and... | 25,129,194 | [
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Patterns of habitual physical activity in youth with and without Prader-Willi Syndrome. | Children classified as overweight or obese and those with disabilities are at a greater risk of not meeting the minimum recommendation of 60 min a day of moderate to vigorous physical activity (PA). Youth with Prader-Willi Syndrome (PWS) appear to participate in less PA compared to nonsyndromal children, likely due to ... | 25,129,202 | [
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... |
Predictable dental rehabilitation in maxillomandibular reconstruction with free flaps. The role of implant guided surgery. | The reconstruction of maxillomandibular defects secondary to oral cancer surgery, represent a great challenge for Maxillofacial surgeons. During the last decades the reconstructive surgery has experimented a big advance due to the development of the microsurgical techniques. At present, we are able to reconstruct compl... | 25,129,241 | [
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Morphological and topographical characteristics of posterior supernumerary molar teeth: an epidemiological study on 25,186 subjects. | To investigate the prevalence , gender difference , arch , morphology and position within the arch of supernumerary molar (SM) teeth in a referred Italian Caucasian population. Records of 25,186 young patients were evaluated. Only data related to supernumerary teeth in the posterior region of the jaws were analyzed. Th... | 25,129,242 | [
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-0.04069152,
-0.02232613,
-0.2365009,
-0.1636082,
-0.08267348,
-0.4876918,
0.144257,
-0.5873992,
-0.6590369,
0.06599709,
0.1296281,
-0.1259721,
0.01824019,
0.2844331,
0.1867399,
-0.1113827,
... |
The clinical significance of CDK1 expression in oral squamous cell carcinoma. | To evaluate the clinical significance of cyclin-dependent kinase 1 (CDK1) in 77 oral squamous cell carcinomas (OSCC) using immunohistochemical methods. Immunohistochemical expression of CDK1 was compared with various clinicopathological features in 77 OSCC and 60 controlled epithelia adjacent to the tumours. In additio... | 25,129,248 | [
0.2478095,
-0.2153325,
-0.1905721,
-0.3463307,
-0.2972844,
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0.1306996,
0.1007682,
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0.04123029,
0.35032,
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0.1074787,
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0.1232276,
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0.1132928,
0.1237713,
0.1523866,
0.4231927,
-0.1699294,
0.4583... |
Is there a polysomnographic signature of augmentation in restless legs syndrome? | Augmentation of restless legs syndrome (RLS) is a potentially severe side-effect of dopaminergic treatment. Data on objective motor characteristics in augmentation are scarce. The aim of this study was to investigate in detail different variables of leg movements (LM) in untreated, treated, and augmented RLS patients. ... | 25,129,261 | [
-0.1071924,
0.1293291,
0.0710469,
-0.2036704,
0.2777957,
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0.0162699,
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0.1276426,
-0.5706367,
0.005776173,
0.01723469,
0.05144568,
0.03520417,
0.411568,
0.07023408,
... |
Hemodynamic effects of Ivabradine in addition to dobutamine in patients with severe systolic dysfunction. | Dobutamine induced tachycardia increases myocardial oxygen consumption and impairs ventricular filling. We hypothesized that Ivabradine may be efficient to control dobutamine induced tachycardia. We assessed the effects of Ivabradine in addition to dobutamine in stable heart failure (HF) patients (LVEF < 35%, n = 22... | 25,129,291 | [
-0.1982835,
-0.05510991,
-0.3889157,
-0.353353,
0.1661459,
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0.1059959,
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-0.3994229,
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0.08283826,
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0.06500276,
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0.121302,
0.0545962,
-0.08301452,
0.2583835,
-0.1319303,
0.2280739,
-0.124263,
0... |
Expression of serum survivin protein in diagnosis and prognosis of gallbladder cancer: a comparative study. | The role of survivin in gallbladder cancer (GBC) has not been evaluated. We investigated survivin protein expression in serum of patients with gallbladder diseases (cholelithiasis, n = 30; GBC, n = 39) and compared with healthy controls (n = 25). Clinicopathological parameters, diagnosis and prognosis of patients with ... | 25,129,311 | [
0.1462465,
-0.1323935,
-0.08298927,
-0.4196617,
-0.329294,
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0.04819831,
0.1255624,
0.1645887,
0.01750122,
0.3094317,
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0.2022275,
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-0.4495021,
0.02038398,
-0.01786893,
0.1802842,
0.2836463,
0.1366668,
-0.001346238,
... |
Gastric residual evaluation in preterm neonates: a useful monitoring technique or a hindrance? | It is routine practice in most neonatal intensive care units to measure the volume and color of gastric residuals (GRs) prior to enteral bolus feedings in preterm very low birth weight infants. However, there is paucity of evidence supporting the routine use of this technique. Moreover, owing to the lack of uniform sta... | 25,129,325 | [
0.1150398,
0.04928807,
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0.1591152,
0.03348838,
0.3252661,
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0.06711877,
0.03142085,
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0.02398364,
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0.1032284,
-0.4009828,
0.3427672,
0.09396808,
-0.299578,
0.1971143,
-0.002016432,
0.09104279,
-... |
Case report: protein-losing enteropathy caused by Mesocestoides vogae (syn. M. corti) in a dog. | An eight-year-old, neutered, female Shetland Sheepdog presented with a 6-week history of small intestinal diarrhea. Regenerative anemia, hypoproteinemia, and an increased plasma C-reactive protein concentration were detected on blood examination. Fecal examination and abdominal radiography were unremarkable. Abdominal ... | 25,129,334 | [
-0.0604764,
0.05935395,
0.4192169,
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0.1523407,
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0.136375,
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0.2492636,
0.3303913,
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0.1070495,
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0.0842362,
-0.3056822,
-0.1388914,
0.1294932,
0.1779124,
-0.1616203,
0.3195106,
-0.3342024,
0.169... |
Osteomyelitis of the foot and ankle: diagnosis, epidemiology, and treatment. | Osteomyelitis of the foot and ankle is a common, potentially devastating condition with diagnostic and treatment challenges. Understanding the epidemiology and pathogenesis of osteomyelitis can raise clinical suspicion and guide testing and treatments. History and physical examination, laboratory studies, vascular stud... | 25,129,362 | [
0.1873703,
0.05108677,
0.02913845,
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0.2435489,
0.2595991,
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0.09596783,
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0.0632055,
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0.01352677,
0.09208246,
-0.1110254,
0.2369046,
-0.117965,
-0.06021689,
-0.215628,
... |
Factors influencing Oncotype DX use in the management of early breast cancer: a single centre experience. | Oncotype DX recurrence score is a multi-gene assay which quantifies the risk of distant recurrence in patients with hormone receptor-positive (HR+) early breast cancer (EBC) treated with tamoxifen, and predicts the magnitude of clinical benefit of adjuvant chemotherapy. This retrospective study examined factors that we... | 25,129,366 | [
0.204898,
0.0008390306,
0.0005260223,
-0.3832814,
-0.2919827,
-0.4225539,
0.09833311,
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-0.02772037,
-0.001339482,
0.6242279,
0.1609511,
-0.1303828,
-0.4796948,
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0.223786,
0.1610466,
0.3449499,
-0.1831714,
-0.1327876,
0.02411045,
-0.169204... |
Retrospective evaluation of thromboembolic events in patients with non-small cell lung cancer treated with platinum-based chemotherapy. | Thromboembolic events (TE) are common in patients with cancer and are potentially life-threatening. In lung cancer, little is known about thrombosis during chemotherapy treatment. The aim of this study was to describe the incidence of TE in patients with non-small cell lung cancer (NSCLC), occurring during treatment wi... | 25,129,368 | [
0.1400403,
0.1855359,
-0.4479864,
-0.4447916,
0.2136472,
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0.16692,
0.254707,
-0.310047,
0.2155855,
0.08789217,
0.4951479,
-0.1108913,
-0.5751796,
0.1554948,
-0.1198012,
-0.09426036,
0.6718134,
0.1648103,
0.3066756,
0.2551295,
0.348922,
-0.0663894,
-0.08256914... |
Caudal extension graft versus columellar strut with plumping graft for acute nasolabial angle correction in rhinoplasty surgery. | Nasal tip support is an important factor to be considered in rhinoplasty surgery. There are several techniques for improving tip support. Caudal extension graft (CEG) and columellar strut with plumping graft (CSPG) are two methods in rhinoplasty surgery. The final goal of this experimental study is to find the most eff... | 25,129,372 | [
0.3438354,
-0.1549083,
-0.09854374,
-0.3327839,
0.2351361,
-0.08634452,
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0.04754873,
-0.11663,
0.1161808,
-0.3033065,
-0.1755241,
-0.1814598,
-0.06724234,
-0.03044394,
-0.0679322,
0.04663511,
0.01501538,
0.1131427,
-0.0141024,
0.2222636,
0.0428473,
... |
Increased frequency of mitral valve prolapse in patients with deviated nasal septum. | Any abnormality of collagen may affect the tissues with higher collagen content, e.g., joints, heart valves, and great arteries. Mitral valve prolapse (MVP) is a characteristic of generalized collagen abnormality. Nasal septum (NS) is constituted by osseous and cartilaginous septums that are highly rich in collagen. We... | 25,129,374 | [
-0.2282574,
0.1802206,
0.08832598,
-0.09531293,
-0.002933985,
-0.5060265,
-0.04344806,
0.2197443,
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-0.0170699,
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0.05117393,
-0.1044047,
-0.1880866,
-0.203326,
-0.1145306,
-0.009421254,
0.0231466,
-0.1121138,
-0.009278249,
0.07508446,
0.1264186,
-0.1... |
Nickel(II) biosorption from aqueous solutions by shrimp head biomass. | The present study evaluates the capacity of shrimp (Farfantepenaeus aztecus) head to remove toxic Ni(II) ions from aqueous solutions. Relevant parameters that could affect the biosorption process, such as shrimp head pretreatment, solution pH level, contact time and initial Ni(II) concentration, were studied in batch s... | 25,129,383 | [
-0.1694037,
-0.03757736,
-0.4586292,
0.02718718,
-0.05130116,
-0.1879421,
-0.2297855,
0.5808935,
-0.04316329,
0.01551788,
0.03332439,
-0.2391199,
-0.2370112,
-0.1929225,
-0.5405655,
-0.4785824,
-0.3974585,
0.01532649,
-0.2566763,
0.4548782,
0.2893159,
0.5488343,
-0.051355... |
In vitro fungicidal photodynamic effect of hypericin on Trichophyton spp. | Hypericin is a natural photosensitizer used in photodynamic therapy (PDT), which has shown in vitro antifungal effect against Candida spp. The aim of this study was to evaluate the in vitro fungicidal effect of hypericin-PDT on dermatophytes. Trichophyton rubrum and Trichophyton mentagrophytes strains were incubated wi... | 25,129,421 | [
0.1358719,
-0.2359316,
-0.07724384,
0.5534115,
0.2132097,
-0.08402158,
0.07279427,
-0.1803151,
0.00611256,
-0.09331086,
0.3013458,
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0.06248501,
0.04561804,
-0.1703413,
-0.08907209,
-0.311436,
0.2196118,
-0.1779693,
-0.3733206,
0.4019221,
0.4733677,
0.05698727,... |
The Postpartum Worry Scale-Revised: continuing validation with a sample of NICU mothers. | This study represents the second validation phase of the Postpartum Worry Scale-Revised (PWS-R). As the PWS-R includes items tapping infant health and development concerns, we compare its psychometric properties with a sample of NICU mothers and the online sample used in the initial validation. We conduct a confirmator... | 25,129,423 | [
-0.06965124,
-0.07611322,
-0.1709479,
-0.382981,
0.1963476,
-0.1431126,
0.06835193,
0.01354265,
0.09112726,
0.0383412,
0.2981363,
0.08314628,
-0.2173387,
-0.1773863,
-0.0246425,
-0.1400779,
-0.4362405,
0.003905976,
0.03740941,
-0.2150113,
0.1807365,
0.05179246,
-0.0931771... |
Transport priorities, risk perception and worry associated with mode use and preferences among Norwegian commuters. | There is currently scant research on the role of transport priorities, risk perception and worry for travel mode use and preferences. The present study aims to examine these factors in relation to mode use and preferences among Norwegian commuters. A web-based survey was conducted in a randomly obtained representative ... | 25,129,446 | [
-0.4509001,
0.0729587,
-0.02600467,
0.05889997,
-0.01575087,
-0.4160662,
-0.06004049,
-0.1301024,
-0.3139053,
0.1281087,
0.145906,
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0.2129444,
0.3879488,
0.1929959,
0.00478748,
-0.8260719,
0.1266102,
-0.1309879,
-0.09039409,
0.2388769,
0.2396114,
-0.00959447,
... |
Modulatory role of vitamin A on the Candida albicans-induced immune response in human monocytes. | Beyond its well-documented role in reproduction, embryogenesis and maintenance of body tissues, vitamin A has attracted considerable attention due to its immunomodulatory effects on both the innate and the adaptive immune responses. In infectious diseases, vitamin A has been shown to have a host-protective effect in in... | 25,129,478 | [
-0.07586414,
-0.1268192,
-0.1771857,
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0.3332541,
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0.4353862,
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0.164303,
0.1923846,
0.04900106,
0.3014354,
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0.06821846,
-0.7416931,
-0.169409,
-0.01308815,
0.06594086,
0.5009727,
0.4173701,
-0.3787363,
... |
Methane emissions among individual dairy cows during milking quantified by eructation peaks or ratio with carbon dioxide. | The aims of this study were to compare methods for examining measurements of CH₄ and CO₂ emissions of dairy cows during milking and to assess repeatability and variation of CH₄ emissions among individual dairy cows. Measurements of CH₄ and CO₂ emissions from 36 cows were collected in 3 consecutive feeding periods. In t... | 25,129,498 | [
0.2541938,
0.1122019,
0.4512491,
0.1157345,
0.03485421,
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-0.190207,
-0.3135796,
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0.037166,
0.3164082,
-0.2000507,
-0.2030221,
0.5711889,
0.1767185,
-0.0... |
Epithelial-derived nuclear IL-33 aggravates inflammation in the pathogenesis of reflux esophagitis. | IL-33 is a new tissue-derived cytokine constitutively expressed in epithelial cells and plays a role in sensing damage caused by inflammatory diseases. The function of IL-33 in the esophageal mucosa has not been previously described. Accordingly, we examined the expression of IL-33 and its role in the pathogenesis of r... | 25,129,514 | [
0.03851118,
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0.1991356,
0.06481163,
0.1619748,
0.09229875,
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0.176991,
0.01346412,
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0.09687988,
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0.0288922,
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0.4073878,
-0.1167278,
0.07796942,
-0.2499756,
-0.06987688,
0.2805959,
0.1816136,
-0.2523834,
... |
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