title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Stress and resilience in military mortuary workers: care of the dead from battlefield to home. | The death of a military service member in war provokes feelings of distress and pride in mortuary workers who process the remains. To further understand their reactions, the authors interviewed 34 military and civilian personnel to learn more about their work stresses and rewards. They review stresses of anticipation, ... | 25,140,840 | [
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Comparison of bilateral and unilateral contractions between swimmers and nonathletes during leg press and hand grip exercises. | The bilateral limb deficit (BLD) is defined as the reduction in force production during bilateral compared with summed unilateral contractions of homologous muscles. The underlying mechanism for the BLD has been elusive to determine. The purpose of this study was to examine the presence of the BLD during maximal isomet... | 25,140,863 | [
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Synthetic antibodies with a human framework that protect mice from lethal Sudan ebolavirus challenge. | The ebolaviruses cause severe and rapidly progressing hemorrhagic fever. There are five ebolavirus species; although much is known about Zaire ebolavirus (EBOV) and its neutralization by antibodies, little is known about Sudan ebolavirus (SUDV), which is emerging with increasing frequency. Here we describe monoclonal a... | 25,140,871 | [
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Biogeographic distribution patterns and their correlates in the diverse frog fauna of the Atlantic Forest hotspot. | Anurans are a highly diverse group in the Atlantic Forest hotspot (AF), yet distribution patterns and species richness gradients are not randomly distributed throughout the biome. Thus, we explore how anuran species are distributed in this complex and biodiverse hotspot, and hypothesize that this group can be distingui... | 25,140,882 | [
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Unexpected metal ion-assisted transformations leading to unexplored bridging ligands in Ni(II) coordination chemistry: the case of PO3F(2-) group. | The initial 'accidental', metal ion-assisted hydrolysis of PF6(-) to PO3F(2-) has been evolved in a systematic investigation of the bridging affinity of the latter group in Ni(II)/oximate chemistry; mono-, di- and trinuclear complexes have been prepared and confirmed both the rich reactivity of PO3F(2-) and its potenti... | 25,140,887 | [
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4-1BBL enhances CD8+ T cell responses induced by vectored vaccines in mice but fails to improve immunogenicity in rhesus macaques. | T cells play a central role in the immune response to many of the world's major infectious diseases. In this study we investigated the tumour necrosis factor receptor superfamily costimulatory molecule, 4-1BBL (CD137L, TNFSF9), for its ability to increase T cell immunogenicity induced by a variety of recombinant vector... | 25,140,889 | [
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Deciphering the glycolipid code of Alzheimer's and Parkinson's amyloid proteins allowed the creation of a universal ganglioside-binding peptide. | A broad range of microbial and amyloid proteins interact with cell surface glycolipids which behave as infectivity and/or toxicity cofactors in human pathologies. Here we have deciphered the biochemical code that determines the glycolipid-binding specificity of two major amyloid proteins, Alzheimer's β-amyloid peptide ... | 25,140,899 | [
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Driving forces for the self-assembly of graphene oxide on organic monolayers. | Graphene oxide (GO) flakes were self-assembled from solution on surfaces of self-assembled monolayers (SAMs), varying in the chemical structure of their head groups. The coverage density of GO relates to strength of attractive interaction, which is largest for Coulomb interaction provided by positively charged SAM head... | 25,140,920 | [
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Oral GS-5806 activity in a respiratory syncytial virus challenge study. | Respiratory syncytial virus (RSV) is a common cause of infant hospitalizations and is increasingly recognized as a cause of considerable morbidity and mortality. No accepted antiviral treatment exists. We conducted a double-blind, placebo-controlled study of GS-5806, an oral RSV-entry inhibitor, in healthy adults who r... | 25,140,957 | [
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Computer-assisted surgery in orthopedic oncology. | In orthopedic oncology, computer-assisted surgery (CAS) can be considered an alternative to fluoroscopy and direct measurement for orientation, planning, and margin control. However, only small case series reporting specific applications have been published. We therefore describe possible applications of CAS and report... | 25,140,984 | [
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Tandem ring-closing metathesis/transfer hydrogenation: practical chemoselective hydrogenation of alkenes. | An operationally simple chemoselective transfer hydrogenation of alkenes using ruthenium metathesis catalysts is presented. Of great practicality, the transfer hydrogenation reagents can be added directly to a metathesis reaction and effect hydrogenation of the product alkene in a single pot at ambient temperature with... | 25,140,991 | [
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Chimpanzees and humans mimic pupil-size of conspecifics. | Group-living typically provides benefits to individual group members but also confers costs. To avoid incredulity and betrayal and allow trust and cooperation, individuals must understand the intentions and emotions of their group members. Humans attend to other's eyes and from gaze and pupil-size cues, infer informati... | 25,140,998 | [
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An early warning system based on syndromic surveillance to detect potential health emergencies among migrants: results of a two-year experience in Italy. | Profound geopolitical changes have impacted the southern and eastern Mediterranean since 2010 and defined a context of instability that is still affecting several countries today. Insecurity combined with the reduction of border controls has led to major population movements in the region and to migration surges from a... | 25,140,999 | [
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Hawthorne effect with transient behavioral and biochemical changes in a randomized controlled sleep extension trial of chronically short-sleeping obese adults: implications for the design and interpretation of clinical studies. | To evaluate the effects of study participation per se at the beginning of a sleep extension trial between screening, randomization, and the run-in visit. Subjects were screened, returned for randomization (Comparison vs. Intervention) after 81 days (median), and attended run-in visit 121 days later. Outpatient. Obese (... | 25,141,012 | [
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Asthma during pregnancy in a population-based study--pregnancy complications and adverse perinatal outcomes. | Asthma is one of the most common chronic diseases, and prevalence, severity and medication may have an effect on pregnancy. We examined maternal asthma, asthma severity and control in relation to pregnancy complications, labour characteristics and perinatal outcomes. We retrieved data on all singleton births from July ... | 25,141,021 | [
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Investigation of the role of protonation of benzophenone and its derivatives in acidic aqueous solutions using time-resolved resonance Raman spectroscopy: how are ketyl radicals formed in aqueous solutions? | The formation mechanism of ketyl radicals and several other selective photoreactions of benzophenone and its derivatives are initiated by the protonation of their triplet state and have been investigated using nanosecond time-resolved resonance Raman spectroscopy (ns-TR(3)) in solutions of varying conditions. Evidence ... | 25,141,023 | [
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Cultured neonatal rat cardiomyocytes display differences in glucose uptake and sensitivity to dexamethasone related to maternal diet. | Feeding a low protein (LP) diet in rat pregnancy is associated with impaired cardiovascular health and function, possibly as a result of tissue remodelling. To assess whether cardiomyocytes retain differences induced by protein restriction, cells from neonatal rats exposed to control or LP diets in utero were cultured ... | 25,141,045 | [
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Mechanistic investigation of the cleavage of phosphodiester catalyzed by a symmetrical oxyimine-based macrocyclic dinuclear zinc complex: a DFT study. | Density functional theory (DFT) was utilized to investigate the hydrolysis reaction mechanisms of phosphodiester BNPP (BNPP = bis(4-nitrophenyl)phosphate) catalyzed by a symmetrical oxyimine-based macrocyclic dinuclear zinc(ii) complex. We examined the nature of the nucleophilic reagent and the active form of the catal... | 25,141,046 | [
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RandomForest4Life: a Random Forest for predicting ALS disease progression. | We describe a method for predicting disease progression in amyotrophic lateral sclerosis (ALS) patients. The method was developed as a submission to the DREAM Phil Bowen ALS Prediction Prize4Life Challenge of summer 2012. Based on repeated patient examinations over a three- month period, we used a random forest algorit... | 25,141,076 | [
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Effects of mental and physical practice on a finger opposition task among children. | We sought to compare the effects of physical practice (PP) and mental practice (MP) on the immediate and long-term learning of the finger-to-thumb opposition sequence task (FOS) in children; in addition, we investigated the transfer of this learning to an untrained sequence of movements and to the contralateral untrain... | 25,141,084 | [
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Sixth-grade physical education: an acculturation of bullying and fear. | Although bullying is recognized as a serious problem among adolescents, more information is needed regarding bullying within the context of physical education. Grounded in a social-ecological framework, the purpose of this investigation was to discover the perceptions students and teachers have about bullying in physic... | 25,141,091 | [
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Thiol-activated gem-dithiols: a new class of controllable hydrogen sulfide donors. | A class of novel thiol-activated H2S donors has been developed on the basis of the gem-dithiol template. These donors release H2S in the presence of cysteine or GSH in aqueous solutions as well as in cellular environments. | 25,141,097 | [
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Treatment priorities in oncology: do we want to live longer or better? | Despite the progress achieved in the fight against cancer over the past several years, assessing the needs, goals and preferences of patients with cancer is of the utmost importance for the delivery of health care. We sought to assess priorities regarding quantity versus quality of life among Brazilian patients, compar... | 25,141,108 | [
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Fluid distribution kinetics during cardiopulmonary bypass. | The purpose of this study was to examine the isovolumetric distribution kinetics of crystalloid fluid during cardiopulmonary bypass. Ten patients undergoing coronary artery bypass grafting participated in this prospective observational study. The blood hemoglobin and the serum albumin and sodium concentrations were mea... | 25,141,112 | [
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The association of vitamin D deficiency with non-alcoholic fatty liver disease. | Vitamin D deficiency has been related to diabetes, hypertension, hyperlipidemia and peripheral vascular disease. In this study, we aimed to investigate the role of vitamin D status in non-alcoholic fatty liver disease. We included 211 consecutive subjects to examine the presence of non-alcoholic fatty liver disease. Of... | 25,141,113 | [
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Silyl phosphorus and nitrogen donor chelates for homogeneous ortho borylation catalysis. | Ir catalysts supported by bidentate silyl ligands that contain P- or N-donors are shown to effect ortho borylations for a range of substituted aromatics. The substrate scope is broad, and the modular ligand synthesis allows for flexible catalyst design. | 25,141,136 | [
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Quantitative estimation of renal function with dynamic contrast-enhanced MRI using a modified two-compartment model. | To establish a simple two-compartment model for glomerular filtration rate (GFR) and renal plasma flow (RPF) estimations by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). A total of eight New Zealand white rabbits were included in DCE-MRI. The two-compartment model was modified with the impulse residue... | 25,141,138 | [
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Asynchrony of seasons: genetic differentiation associated with geographic variation in climatic seasonality and reproductive phenology. | Many organisms exhibit distinct breeding seasons tracking food availability. If conspecific populations inhabit areas that experience different temporal cycles in food availability spurred by variation in precipitation regimes, then they should display asynchronous breeding seasons. Thus, such populations might exhibit... | 25,141,144 | [
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Nutrient limitation and physiology mediate the fine-scale (de)coupling of biogeochemical cycles. | Nutrients in the environment are coupled over broad timescales (days to seasons) when organisms add or withdraw multiple nutrients simultaneously and in ratios that are roughly constant. But at finer timescales (seconds to days), nutrients become decoupled if physiological traits such as nutrient storage limits, circad... | 25,141,147 | [
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Unexpected primary reactions for thermolysis of 1,1-diamino-2,2-dinitroethylene (FOX-7) revealed by ab initio calculations. | The primary thermolysis reactions of a promising insensitive explosive 1,1-diamino-2,2-dinitroethylene (DADNE, FOX-7) have been studied in the gas phase at a high level of theory (CCSD(T)-F12/aVTZ). Our calculations revealed that none of the conventional reactions (C-NO2 bond fission, nitro-nitrite and nitro-aci-nitro ... | 25,141,156 | [
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The lack of impact of peri-implantation or late gestation nutrient restriction on ovine fetal renal development and function. | Unbalanced nutrition during critical windows of development is implicated in determining the susceptibility to hypertension and cardiovascular disease in adult life, but the underlying mechanisms during fetal life have not been fully elucidated. We investigated the effects of moderate nutritional restriction during cri... | 25,141,168 | [
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Influence of bismuth oxide concentration on the pH level and biocompatibility of white Portland cement. | To investigate if there is a relation between the increase of bismuth oxide and the decrease of pH levels and an intensification of toxicity in the Portland cement. White Portland cement (WPC) was mixed with 0, 15, 20, 30 and 50% bismuth oxide, in weight. For the pH level test, polyethylene tubes were filled with the c... | 25,141,197 | [
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Clues for minimal hepatic encephalopathy in children with noncirrhotic portal hypertension. | In children with noncirrhotic extrahepatic portal vein obstruction (EHPVO), minimal hepatic encephalopathy (MHE) was reported in a few series, but neither is it routinely investigated nor does consensus about its diagnosis exist. In this prospective observational study we aimed at detecting the prevalence of MHE in chi... | 25,141,228 | [
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Gut microbiota and inflammatory bowel disease: the role of antibiotics in disease management. | Imbalances in the composition and number of bacteria in the gut microbiota have been implicated in inflammatory bowel disease (IBD), and modulation of the gut microbiota by probiotics and antibiotics in IBD has been an active area of research, with mixed results. This narrative review summarizes the findings of relevan... | 25,141,239 | [
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A semipermeable enzymatic nanoreactor as an efficient modulator for reversible pH regulation. | Here we propose a new concept for the fabrication of a semipermeable enzymatic nanoreactor as an efficient modulator to reversibly switch the pH of an aqueous environment. We used amino-functionalized, expanded mesoporous silica nanoparticles (EMSN) as a model nanocarrier to load enzymes. In order to protect enzymes fr... | 25,141,270 | [
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Risk of bias in trial-based economic evaluations: identification of sources and bias-reducing strategies. | The objectives of this article are first to give an overview of the risks of bias in trial-based economic evaluations and, second, to identify how key sources for bias can be revealed and overcome (i.e. what bias-reducing strategies might be employed) in future trial-based economic evaluations in the field of health ps... | 25,141,273 | [
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Relationship of preexisting influenza hemagglutination inhibition, complement-dependent lytic, and antibody-dependent cellular cytotoxicity antibodies to the development of clinical illness in a prospective study of A(H1N1)pdm09 Influenza in children. | The hemagglutination inhibition (HAI) antibody titer is considered the primary immune correlate of protection for influenza. However, recent studies have highlighted the limitations on the use of the HAI titer as a correlate in at-risk populations such as children and older adults. In addition to the neutralization of ... | 25,141,276 | [
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Generation and Evaluation of a Genome-Scale Metabolic Network Model of Synechococcus elongatus PCC7942. | The reconstruction of genome-scale metabolic models and their applications represent a great advantage of systems biology. Through their use as metabolic flux simulation models, production of industrially-interesting metabolites can be predicted. Due to the growing number of studies of metabolic models driven by the in... | 25,141,288 | [
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Predicting progression of Alzheimer's disease using ordinal regression. | We propose a novel approach to predicting disease progression in Alzheimer's disease (AD)--multivariate ordinal regression--which inherently models the ordered nature of brain atrophy spanning normal aging (CTL) to mild cognitive impairment (MCI) to AD. Ordinal regression provides probabilistic class predictions as wel... | 25,141,298 | [
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Role of serum myeloperoxidase, CPK, CK-MB, and cTnI tests in early diagnosis of myocardial ischemia during ERCP. | Some patients may experience retrosternal pain during ERCP, which may be a pioneer of a serious myocardial problem, and early diagnosis is very important for the prognosis and management. In the study, we aimed to investigate the role of serum cardiac biomarkers, such as myeloperoxidase (MPO), creatine phospokinase (CP... | 25,141,318 | [
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Mutatis mutandis: are we diagnosing too many people with non-celiac gluten sensitivity? Multiple case report. | We report three patients presenting with gluten-related signs and symptoms. Since villous height/crypt depth ratio, intraepithelial lymphocyte count, and serum antibody tests were not diagnostic for celiac disease (CD), a diagnosis of non-celiac gluten sensitivity (NCGS) was suggested. On the other hand, antibodies sug... | 25,141,323 | [
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Could thermal sensitivity of mitochondria determine species distribution in a changing climate? | For many aquatic species, the upper thermal limit (Tmax) and the heart failure temperature (THF) are only a few degrees away from the species' current environmental temperatures. While the mechanisms mediating temperature-induced heart failure (HF) remain unresolved, energy flow and/or oxygen supply disruptions to card... | 25,141,346 | [
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Evaluating the efficacy of Tui Na in treatment of childhood anorexia: a meta-analysis. | Medical practitioners are now seeing more children younger than 15 y who are developing childhood anorexia. Hua Tuo chiropractic treatments are an ancient and practical massage therapy and are a type of Tui Na therapy, which has been used for curing childhood anorexia for thousands of years in China. Research literatur... | 25,141,371 | [
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The use of bioimpedance spectroscopy to monitor therapeutic intervention in patients treated for breast cancer related lymphedema. | We performed a multi-institutional analysis to evaluate the ability of bioimpedance spectroscopy (BIS) to capture the impact of lymphedema treatment compared with observation alone in the management of breast cancer related lymphedema (BCRL). We utilized a retrospective review of 50 patients with breast cancer who were... | 25,141,461 | [
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Structural relationship between microlymphatic and microvascullar blood vessels in the rabbit ventricular myocardium. | We investigated the distribution and relationship between draining lymphatic vessels, lymphatic capillaries, and microvascular blood vessels in rabbit ventricular tissue. The left and right ventricular tissue from 15 healthy adult rabbits was obtained, processed, and sectioned for analysis. 5'-nucleotidase-alkaline pho... | 25,141,462 | [
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Intracranial venous drainage through spinal veins. | There is extensive collateral networking at the craniocervical junction with a substantial anatomical and functional continuity between the veins, venous sinuses, and venous plexuses of the brain and spine. The predominant pathway for intracranial blood outflow may depend on the level and degree of obstruction. We are ... | 25,141,475 | [
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Therapy-resistant metastasizing anaplastic spermatocytic seminoma: a cytogenetic hybrid: a case report. | Anaplastic spermatocytic seminoma is a rare variant of the conventional spermatocytic seminoma, with only 6 cases reported up to now. The anaplastic variant contains only the medium-sized cell type, hallmarked by large-sized nucleoli, whereas the small lymphocyte-like and giant cells typical of the conventional spermat... | 25,141,494 | [
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Walking and stair climbing abilities in individuals after chronic stroke with and without mental health problem. | To compare muscle strength, balance, walking and stair climbing abilities among individuals after chronic stroke with or without mental health problems; to describe their physiological response after stress stimulation. Subjects who had their first stroke more than one year ago were classified for mental health problem... | 25,141,520 | [
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Weight and body mass index in men and age and height in women relate to difficulty and ability in performing activities in community-living Thai elders. | To compare difficulty between male and female community-living elderly in performing activities (DDA), ability in performing living activities (ADA) and balance, and to explore associations among them related to age, weight, height and body mass index (BMI). In all, 1,964 participants (646 men, 1,318 women) aged 60 or ... | 25,141,523 | [
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Online self-report questionnaire on computer work-related exposure (OSCWE): validity and internal consistency. | To develop an online, self-report questionnaire on computer work-related exposure (OSCWE) and to determine the internal consistency, face and content validity of the questionnaire. The online, self-report questionnaire was developed to determine the risk factors related to musculoskeletal disorders in computer users. I... | 25,141,533 | [
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Immediate effects of trunk stabilizer muscles training on muscle response time in individuals with non-specific chronic low back pain. | To investigate immediate effects of biofeedback training on motor control performance in participants with nonspecific chronic low back pain. RCT was conducted. The training group received isolated and co-contraction training of trunk stabilizers in lying on the left side, sitting on stool and sitting on a gymnastic ba... | 25,141,535 | [
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The role of number of tasks in determining the relevance of information. | Our objective was to explore the value of considering the number of tasks that use a piece of information when calculating the relevance information has to an operator. Whereas frequency and criticality of information are often identified as information attributes, the number of tasks that use the information is rarely... | 25,141,598 | [
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Emergency medical equipment storage: benefits of visual cues tested in field and simulated settings. | We tested the effectiveness of an illustrated divider ("the divider") for bedside emergency equipment drawers in an intensive care unit (ICU). In Study I, we assessed whether the divider increases completeness and standardizes the locations of emergency equipment within the drawer. In Study 2, we investigated whether t... | 25,141,599 | [
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Steering in a random forest: ensemble learning for detecting drowsiness-related lane departures. | The aim of this study was to design and evaluate an algorithm for detecting drowsiness-related lane departures by applying a random forest classifier to steering wheel angle data. Although algorithms exist to detect and mitigate driver drowsiness, the high rate of false alarms and missed detection of drowsiness represe... | 25,141,601 | [
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Domestication of Mahseer (Tor soro) in Indonesia. | Mahseer is an economically important fish in the world with a distribution from the Himalayan Mountains up to Southeast Asia. One species of Masheer is Tor soro in the Indonesian Archipelago. For a long time, T. soro has been collected from the wild and now is becoming rare. In addition, the degradation of its habitat ... | 25,141,656 | [
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Diverse thermoresponsive behaviors of uncharged UCST block copolymer micelles in physiological medium. | Three amphiphilic diblock copolymers, representative of three types of block copolymer (BCP) design, were synthesized using reversible addition-fragmentation chain-transfer (RAFT) polymerization. All of them have a same uncharged block of a random copolymer of commercially available acrylamide and acrylonitrile, P(AAm-... | 25,141,758 | [
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XacR - a novel transcriptional regulator of D-xylose and L-arabinose catabolism in the haloarchaeon Haloferax volcanii. | The haloarchaeon Haloferax volcanii degrades D-xylose and L-arabinose via oxidative pathways to α-ketoglutarate. The genes involved in these pathways are clustered and were transcriptionally upregulated by both D-xylose and L-arabinose suggesting a common regulator. Adjacent to the gene cluster, a putative IclR-like tr... | 25,141,768 | [
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Lower heart rate variability predicts increased level of C-reactive protein 4 years later in healthy, nonsmoking adults. | Inflammation and vagally mediated heart rate variability (vmHRV) have been implicated in a number of conditions including diabetes and cardiovascular disease. Consistent with the inflammatory reflex termed the 'cholinergic anti-inflammatory pathway', numerous cross-sectional studies have demonstrated negative associati... | 25,141,771 | [
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Prevalence and validity of self-reported smoking in Indigenous and non-Indigenous young adults in the Australian Northern Territory. | In this study, we used data from Australia's Northern Territory to assess differences in self-reported smoking prevalence between the Indigenous and non-Indigenous populations. We also used urinary cotinine data to assess the validity of using self-reported smoking data in these populations. The Aboriginal Birth Cohort... | 25,141,772 | [
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Evaluation of a new person-centered integrated care model in psychiatry. | The present study evaluated a new integrated treatment concept offering inpatient care, acute psychiatric day hospital and outpatient treatment by the same therapeutic team. 178 patients participated in this randomized controlled trial. Data on psychopathology, global and social functioning, patient satisfaction, conti... | 25,141,779 | [
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The developmental origins of sarcopenia: from epidemiological evidence to underlying mechanisms. | Sarcopenia is defined as the loss of skeletal muscle mass and strength with age. There is increasing recognition of the serious health consequences in terms of disability, morbidity and mortality as well as major healthcare costs. Adult determinants of sarcopenia including age, gender, size, levels of physical activity... | 25,141,783 | [
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Searching for very early precursors of autism spectrum disorders: the Hamamatsu Birth Cohort for Mothers and Children (HBC). | Autism spectrum disorders (ASD) are life-long neurodevelopmental conditions. The pathophysiology is poorly understood, and the clinical diagnosis can only be made through behavioural assessments. The prevalence of ASD has increased eight-fold over the last three decades. Paralleling this rise, research interest in the ... | 25,141,784 | [
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Study protocol: the JEU cohort study--transversal multiaxial evaluation and 5-year follow-up of a cohort of French gamblers. | There is abundant literature on how to distinguish problem gambling (PG) from social gambling, but there are very few studies of the long-term evolution of gambling practice. As a consequence, the correlates of key state changes in the gambling trajectory are still unknown. The objective of the JEU cohort study is to i... | 25,141,820 | [
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Direct measurement of interaction forces between charged multilamellar vesicles†. | Depletion-attraction induced adhesion of two giant (∼ 40 μm), charged multilamellar vesicles is studied using a new Cantilevered-Capillary Force Apparatus, developed in this laboratory. The specific goal of this work is to investigate the role of dynamics in the adhesion and de-adhesion processes when the vesicles come... | 25,141,827 | [
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Metal artifact reduction sequence MRI abnormalities occur in metal-on-polyethylene hips. | To determine the importance of MRI abnormalities in metal-on-metal (MoM) bearings, it is important to understand the baseline features of this diagnostic tool in conventional metal-on-polyethylene (MoP) bearings. What are the frequency, size, and types of MRI-documented adverse local tissue reactions in asymptomatic pa... | 25,141,843 | [
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Partner notification among men who have sex with men and heterosexuals with STI/HIV: different outcomes and challenges. | Partner notification effectiveness among index clients diagnosed with HIV, syphilis and/or gonorrhoea at sexually transmitted infection (STI) clinics was evaluated between 2010 and 2012. We explored percentages of identifiable, notified and tested partners by sexual preference and gender. Partner notification trends we... | 25,141,854 | [
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Potential importance of transition metals in the induction of DNA damage by sperm preparation media. | What are the mechanisms by which the preparation of spermatozoa on discontinuous density gradients leads to an increase in oxidative DNA damage? The colloidal silicon solutions that are commonly used to prepare human spermatozoa for assisted reproduction technology (ART) purposes contain metals in concentrations that p... | 25,141,857 | [
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Maternal supplementation with vitamin A or β-carotene and cardiovascular risk factors among pre-adolescent children in rural Nepal. | Vitamin A plays an important role in fetal renal and cardiovascular development, yet there has been little research on its effects on cardiovascular risk factors later in childhood. To examine this question, we followed the children of women who had been participants in a cluster-randomized, double blind, placebo-contr... | 25,141,874 | [
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Inferior mesenteric vein serves as an alternative guide for transection of the pancreatic body during pancreaticoduodenectomy with concomitant vascular resection: a comparative study evaluating perioperative outcomes. | Tumors of the pancreatic head often involve the superior mesenteric and portal veins. The purpose of this study was to assess perioperative outcomes after pancreaticoduodenectomy (PD) with concomitant vascular resection using the inferior mesenteric vein (IMV) as a guide for transection of the pancreatic body (Whipple ... | 25,141,915 | [
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Establishing a panel of chemo-resistant mesothelioma models for investigating chemo-resistance and identifying new treatments for mesothelioma. | Mesothelioma is inherently chemo-resistant with only 50% of patients responding to the standard of care treatments, and consequently it has a very grim prognosis. The aim of this study was to establish a panel of chemo-resistant mesothelioma models with clinically relevant levels of resistance as tools for investigatin... | 25,141,917 | [
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Early infancy - a critical period for development of obesity. | Abundant epidemiologic evidence from the developed world now shows that more rapid weight gain during the first half of infancy predicts later obesity and cardio-metabolic risk. In countries in transition, in which stunting is still prevalent, distinguishing the effects of gain in weight from linear growth remains a ch... | 25,141,932 | [
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The interleukins IL-6 and IL-1Ra: a mediating role in the associations between BMI and birth weight? | The biological mechanisms in the association between maternal body mass index (BMI) and birth weight are not well understood, but are likely to involve maternal plasma glucose levels and nutrient transport across the placenta, both important modulators of fetal growth. Adipose tissue contributes to circulating levels o... | 25,141,934 | [
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Copper-catalyzed decarboxylative C-P cross-coupling of alkynyl acids with H-phosphine oxides: a facile and selective synthesis of (E)-1-alkenylphosphine oxides. | A novel and efficient copper-catalyzed decarboxylative cross-coupling of alkynyl acids for the stereoselective synthesis of E-alkenylphosphine oxides has been developed. In the presence of 10 mol % of CuCl without added ligand, base, and additive, various alkynyl acids reacted with H-phosphine oxides to afford E-alkeny... | 25,141,945 | [
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Genetic markers of cisplatin-induced hearing loss in children. | This journal recently published a Commentary by Ratain and colleagues at the University of Chicago that criticizes our work on cisplatin-induced hearing loss in children. It is unfortunate that neither the authors nor the editors of Clinical Pharmacology & Therapeutics corresponded with us to provide an earlier opp... | 25,141,953 | [
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PSI showed higher tolerance to Sb(V) than PSII due to stimulation of cyclic electron flow around PSI. | The knowledge of the effects of Sb(V) on the physiological characteristics of cyanobacteria was still limited. In the present study, responses of photosystem I and II (PSI and PSII), cyclic electron flow (CEF), and interphotosystem electron transport of Microcystis aeruginosa to 5-100 mg/l Sb(V) were synchronously meas... | 25,141,964 | [
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Impaired erythrocyte deformability in transgenic HO-1G143H mutant mice. | To investigate the potential effects of variation of HO-1 activity on hemorheology, this study compared the hemorheological properties between transgenic HO-1G143H mutant mice and wild-type (WT) control mice. Fresh blood samples were obtained from mice via the ocular venous sinus. The whole blood viscosity was measured... | 25,141,966 | [
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Burden of stroke in Puerto Rico. | Stroke is the fifth leading cause of death and the first cause of long-term disability in Puerto Rico. Trained staff reviewed and independently validated the medical records of patients who had been hospitalized with possible stroke at any of the 20 largest hospitals located in Puerto Rico during 2007, 2009, and 2011. ... | 25,141,980 | [
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Construction of an uricase nanoparticles modified au electrode for amperometric determination of uric acid. | A method is described for preparation of uricase nanoparticles (100 nm in size) and their direct immobilization onto the Au electrode. The enzyme electrode along with Ag/AgCl as reference and Pt as auxiliary electrode were connected through potentiostat/galvanostat to construct an amperometric uric acid biosensor. The ... | 25,141,984 | [
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A metabolic trade-off between phosphate and glucose utilization in Escherichia coli. | Getting the most out of available nutrients is a key challenge that all organisms face. Little is known about how they optimize and balance the simultaneous utilization of multiple elemental resources. We investigated the effects of long-term phosphate limitation on carbon metabolism of the model organism Escherichia c... | 25,141,987 | [
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Beyond birthweight: the maternal and placental origins of chronic disease. | New findings on the maternal and placental programming of chronic disease lead to four conclusions: (1) Growth of the placental surface is polarized from the time of implantation, so that growth along the major axis, the length, is qualitatively different from growth along the minor axis, the breadth. (2) The human fet... | 25,142,007 | [
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Altered microglial phagocytosis in GPR34-deficient mice. | GPR34 is a Gi/o protein-coupled receptor (GPCR) of the nucleotide receptor P2Y12 -like group. This receptor is highly expressed in microglia, however, the functional relevance of GPR34 in these glial cells is unknown. Previous results suggested an impaired immune response in GPR34-deficient mice infected with Cryptococ... | 25,142,016 | [
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Expansion of a 2 + 2 macrocycle into a 6 + 6 macrocycle: template effect of cadmium(II). | The reaction of trans-1,2-diaminocyclopentane with 2,6-diformylpyridine results in formation of 2 + 2, 3 + 3, and 4 + 4 Schiff base macrocycles as well as trace amounts of 6 + 6 and 8 + 8 macrocycles. In contrast, the 6 + 6 Schiff base macrocycle is a dominant product of the reaction of the isolated 2 + 2 macrocycle wi... | 25,142,027 | [
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Monodisperse carboxyl-functionalized poly(ethylene glycol)-coated magnetic poly(glycidyl methacrylate) microspheres: application to the immunocapture of β-amyloid peptides. | Identification and evaluation of small changes in β-amyloid peptide (Aβ) levels in cerebrospinal fluid is of crucial importance for early detection of Alzheimer's disease. Microfluidic detection methods enable effective preconcentration of Aβ using magnetic microparticles coated with Aβ antibodies. Poly(glycidyl methac... | 25,142,028 | [
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0.3798086,
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0.2073042,
0.255826,
0.07670488,
0.3920654,
-... |
Biomarkers of sepsis and their potential value in diagnosis, prognosis and treatment. | Biomarkers have great potential to improve the diagnosis and treatment of sepsis. The available literature supports the potential utility of sTREM-1, IL-27, suPAR, neutrophil CD64, presepsin, cfDNA and miRNAs as novel diagnostic, prognostic and treatment response biomarkers. The future of sepsis biomarkers lies in exte... | 25,142,036 | [
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0.1413723,
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... |
The effect of different concentrations of linseed oil or fish oil in the maternal diet on the fatty acid composition and oxidative status of sows and piglets. | N-3 polyunsaturated fatty acids (PUFA) are essential for foetal development. Hence, including n-3 PUFA in the sow diet can be beneficial for reproduction. Both the amount and form (precursor fatty acids vs. long chain PUFA) of supplementation are important in this respect. Furthermore, including n-3 PUFA in the diet ca... | 25,142,040 | [
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... |
Environmental and genetic effects on weight and visual score traits at postweaning in Suffolk sheep. | This study aimed to investigate the following environmental effects in Suffolk lambing: contemporary groups, type of birth, and age of animal and age of dam at lambing on conformation (C), precocity (P), musculature (M), and body weight at postweaning (W), and the heritability coefficients and genetic correlations amon... | 25,142,054 | [
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0.4725176,
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IRBIS: a systematic search for conserved complementarity. | IRBIS is a computational pipeline for detecting conserved complementary regions in unaligned orthologous sequences. Unlike other methods, it follows the "first-fold-then-align" principle in which all possible combinations of complementary k-mers are searched for simultaneous conservation. The novel trimming procedure r... | 25,142,064 | [
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Prospective, randomized, double-blinded trial of bone marrow cell transplantation combined with coronary surgery - perioperative safety study. | We present here a sub-study of our prospective, randomized, double-blinded trial of bone marrow mononuclear cell (BMMC) transplantation with coronary artery bypass surgery (CABG) (ClinicalTrials.gov Identifier: NCT00418418), evaluating our secondary end-point concerning hospital stay as well as perioperative morbidity.... | 25,142,068 | [
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0.2855669,
0.259851,
... |
Replication competent virus as an important source of bias in HIV latency models utilizing single round viral constructs. | The central memory T cell (TCM) model forms a unique HIV-1 latency model based on primary cells that closely resemble in vivo TCM. The virus employed in this model is based on an engineered vector incapable of replication after initial infection. We show that despite this strategy, replication competent viral particles... | 25,142,072 | [
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Mild copper-TBAF-catalyzed N-arylation of sulfoximines with aryl siloxanes. | An efficient copper-TBAF-catalyzed C-N bond formation of sulfoximines with arylsiloxanes in dichloromethane at room temperature, affording the desired N-aryl sulfoximines in good to excellent yields under an oxygen atmosphere, is reported. This method complements the existing synthetic approaches due to some advantageo... | 25,142,135 | [
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0.2694014,
0.03127872,
0.2795015,
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High and prolonged sulfamidase secretion by the liver of MPS-IIIA mice following hydrodynamic tail vein delivery of antibiotic-free pFAR4 plasmid vector. | Mucopolysaccharidosis type IIIA (MPS-IIIA) or Sanfilippo A syndrome is a lysosomal storage genetic disease that results from the deficiency of the N-sulfoglucosamine sulfohydrolase (SGSH) protein, a sulfamidase required for the degradation of heparan sulfate glycosaminoglycans (GAGs). The accumulation of these macromol... | 25,142,140 | [
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0.08716125,
0.2651388,
0.3057899,
0.09371245,
-0... |
Migraine and restless legs syndrome: a systematic review. | Restless legs syndrome (RLS) is increasingly being reported as a comorbidity of migraine. We conducted a systematic review and meta-analysis of studies investigating RLS in headache/migraine and vice versa. We calculated the prevalence and 95% confidence intervals (CI) of RLS in headache/migraine, of headache/migraine ... | 25,142,142 | [
0.1160021,
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Disposal of iNKT cell deficiency and an increase in expression of SLAM signaling factors characterizes sarcoidosis remission: a 4-year longitudinal study. | Invariant NKT (iNKT) cells are regulatory lymphocytes that may be important in disorders with increased Th1 responses. We utilized a 4-year longitudinal observational study of iNKT cells and SLAM signaling pathway factors, which are important for iNKT development in patients with newly diagnosed sarcoidosis. Detailed c... | 25,142,143 | [
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0.4674863,
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Involvement of patients with lung and gynecological cancer and their relatives in psychosocial cancer rehabilitation: a narrative review. | Getting cancer is stressful for most patients and their relatives, and research has shown that psychosocial support is needed. Still, cancer care fails to appropriately address psychosocial problems associated with cancer. Research on this topic is often seen from the perspective of either the patient or the relative, ... | 25,142,155 | [
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0.1160311,
0.04635535,
0.2430317,
-0.0129762... |
Characterization of the frhAGB-encoding hydrogenase from a non-methanogenic hyperthermophilic archaeon. | The F420-reducing hydrogenase has been known as a key enzyme in methanogenesis. Its homologs have been identified in non-methanogenic hyperthermophilic archaea, including Thermococcus onnurineus NA1, but neither physiological function nor biochemical properties have been reported to date. The enzyme of T. onnurineus NA... | 25,142,159 | [
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0.2076079,
0.1298734,
-0.3835154,
... |
A depletion layer in polymer solutions at an interface oscillating at the subnano- to submicrometer scale. | The mobility of segments of the polymer mesh in a solution determines the dynamic response of the depletion layer (DL) to mechanical stimuli. This phenomenon can be used to vastly decrease the local viscosity experienced by any device performing periodic motion at the nano- and microscale in complex liquids. We refined... | 25,142,160 | [
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0.170393,
0.2619155,
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0.004... |
Dietary requirement for serum-derived bovine immunoglobulins in the clinical management of patients with enteropathy. | A variety of human disease conditions are associated with chronic intestinal disorders or enteropathies that are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Such disruptions in the homeostasis of the gastrointestinal (GI) tract can lead to symptoms of ... | 25,142,170 | [
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0.09149966,
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0.1686483,
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0.2332036,
-0.3090515,
... |
Expansive open-door laminoplasty secured with titanium miniplates is a good surgical method for multiple-level cervical stenosis. | Laminoplasty is an effective procedure for treating cervical spondylotic myelopathy (CSM). Little information is available regarding the surgical outcomes of expansive open-door laminoplasty (EOLP) when securing with titanium miniplates without bone grafting. This study is aimed to elucidate the efficacy of and problem... | 25,142,174 | [
0.1485159,
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0.1751823,
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CXCL16 haplotypes in patients with human carotid atherosclerosis: preliminary results. | Chemokine CXC ligand 16 (CXCL16) has chemoattractive, adhesive and scavenging properties and may play a role in the formation of atherosclerotic lesions. However, studies of CXCL16 polymorphisms in patients with atherosclerosis are scarce. The missense polymorphisms I123T and A181V are potentially important factors in ... | 25,142,184 | [
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In vitro and in vivo metabolism of 14C-AZ11, a novel inhibitor of bacterial DNA gyrase/type II topoisomerase. | 1. (2R,4S,4aS)-11-Fluoro-2,4-dimethyl-8-((S)-4-methyl-2-oxooxazolidin-3-yl)-2,4,4a,6-tetrahydro-1H,1'H-spiro [isoxazolo[4,5-g][1,4]oxazino[4,3-a]quinoline-5,5'-pyrimidine]-2',4',6'(3'H)-trione (AZ11) is a novel mode-of-inhibition bacterial topoisomerase inhibitor that entered preclinical development for the treatment o... | 25,142,218 | [
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-0.06629728,
-0.2669305,
-0.04814018,
0.1833484,
0.2332373,
-0.00999732... |
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