title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Ultrastructure of the Algivorous Amoeboflagellate Viridiraptor invadens (Glissomonadida, Cercozoa). | The family Viridiraptoridae represents a morphologically and ecologically distinct lineage of glissomonad flagellates (Cercozoa, Rhizaria). It currently comprises two highly specialised, algivorous genera inhabiting freshwater ecosystems, Orciraptor and Viridiraptor, for which ultrastructural data were lacking. In this... | 25,150,610 | [
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Proteomics analysis of altered cellular metabolism induced by insufficient copper level. | Insufficient copper level in the mammalian cell culture medium resulted in lactate accumulation while maintaining similar growth and culture viability profiles. Label-free, LC-MS/MS-based shotgun proteomics method was applied to compare the protein expression profiles obtained from the cultures exposed to suboptimal co... | 25,150,618 | [
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Concordant B-cell precursor acute lymphoblastic leukemia in non-twinned siblings. | Associating the risk of childhood acute lymphoblastic leukemia (ALL) with genetic predisposition is still a challenge. Here, we discuss two non-twinned sibs (girl and boy) diagnosed with B-cell precursor (BCP-ALL) and ETV6-RUNX1. BCP-ALL clinical onset occurred 10months apart from each diagnosis. One child is alive in ... | 25,150,625 | [
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An adaptive radiotherapy planning strategy for bladder cancer using deformation vector fields. | Adaptive radiotherapy (ART) has considerable potential in treatment of bladder cancer due to large inter-fractional changes in shape and size of the target. The aim of this study was to compare our clinically applied method for plan library creation that involves manual bladder delineations (Clin-ART) with a method usi... | 25,150,634 | [
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Risk factors for radiotherapy incidents and impact of an online electronic reporting system. | To ascertain the rate, type, significance, trends and the potential risk factors associated with radiotherapy incidents in a large academic department. Data for all radiotherapy activities from July 2001 to January 2011 were reviewed from radiotherapy incident reporting forms. Patient and treatment data were obtained f... | 25,150,636 | [
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Assessing patterns of spatial behavior in health studies: their socio-demographic determinants and associations with transportation modes (the RECORD Cohort Study). | Prior epidemiological studies have mainly focused on local residential neighborhoods to assess environmental exposures. However, individual spatial behavior may modify residential neighborhood influences, with weaker health effects expected for mobile populations. By examining individual patterns of daily mobility and ... | 25,150,652 | [
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Social capital and adolescent smoking in schools and communities: a cross-classified multilevel analysis. | We sought to determine whether social capital at the individual-, school- and community-level can explain variance in adolescent smoking and accounts for social inequalities in smoking. We collected data as part of the 2005/6 Health Behavior in School-aged Children survey, a nationally representative survey of the heal... | 25,150,654 | [
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Bucking social norms: examining anomalous fertility aspirations in the face of HIV in Lusaka, Zambia. | In settings of high fertility and high HIV prevalence, individuals are making fertility decisions while simultaneously trying to avoid or manage HIV. We sought to increase our understanding of how individuals dually manage HIV risk while attempting to achieve their fertility goals as part of the project entitled HIV St... | 25,150,655 | [
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Selecting measures for balance and mobility to improve assessment and treatment of individuals after stroke. | Assessment of individuals with stroke using reliable and valid outcome measures is a key component of the treatment planning process. Health care professionals may have difficulty selecting balance and mobility measures given the large number of measures to choose from. This article utilizes a case-based approach to de... | 25,150,662 | [
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Task matters: influence of different cognitive tasks on cognitive-motor interference during dual-task walking in chronic stroke survivors. | The impact of unilateral brain damage, such as that caused by stroke, on the interaction between higher cognitive functions and walking remains uncertain. We compared cognitive-motor interference (CMI) during dual-task (DT) walking between chronic stroke survivors and young adults performing explicitly different cognit... | 25,150,667 | [
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Impacts of powdered activated carbon addition on trihalomethane formation reactivity of dissolved organic matter in membrane bioreactor effluent. | Characteristics and trihalomethane (THM) formation reactivity of dissolved organic matter (DOM) in effluents from two membrane bioreactors (MBRs) with and without powdered activated carbon (PAC) addition (referred to as PAC/MBR and MBR, respectively) were examined to investigate the effects of PAC addition on THM forma... | 25,150,685 | [
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A comparative protein profile of mammalian erythrocyte membranes identified by mass spectrometry. | A comparative analysis of erythrocyte membrane proteins of economically important animals, goat (Capra aegagrus hircus), buffalo (Bubalus bubalis), pig (Sus scrofa), cow (Bos tauras), and human (Homo sapiens) was performed. Solubilized erythrocyte membrane proteins were separated by sodium dodecyl sulfate-polyacryamide... | 25,150,706 | [
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The use of biomarkers for the etiologic diagnosis of MCI in Europe: an EADC survey. | We investigated the use of Alzheimer's disease (AD) biomarkers in European Alzheimer's Disease Consortium centers and assessed their perceived usefulness for the etiologic diagnosis of mild cognitive impairment (MCI). We surveyed availability, frequency of use, and confidence in diagnostic usefulness of markers of brai... | 25,150,733 | [
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Comparison of operative and non-operative outcomes based on surgical selection criteria for patients with Chiari I malformations. | Few studies have directly compared operative and non-operative outcomes in Chiari I patients. We evaluated risk factors for clinical improvement in 177 patients in order to help determine the optimal treatment of these often difficult to treat patients. The mean age at surgery for the operative treatment group was 29.9... | 25,150,760 | [
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Arterial fenestrations and their association with cerebral aneurysms. | Fenestrations of intracranial arteries and associated aneurysms are rare. The significance of these fenestrations in relation to aneurysms remains unclear. We present four patients with fenestration-associated aneurysms and a comprehensive review of associations with aneurysms and other vascular lesions. A PubMed searc... | 25,150,765 | [
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Relationships among cognitive impairment, sleep, and fatigue in Parkinson's disease using the MDS-UPDRS. | Non-motor complications of Parkinson's disease (PD), specifically cognitive impairment, sleep disturbances, and fatigue, are recognized as important contributors to poor patient outcomes and quality of life. How sleep problems and fatigue interrelate and impact cognitive function, however, has not systematically been i... | 25,150,770 | [
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Photoinduced electron transfer (PET) based label-free aptasensor for platelet-derived growth factor-BB and its logic gate application. | Platelet-derived growth factor-BB (PDGF-BB) is often overexpressed in human malignant tumors as an indicator for tumor angiogenesis. Here by the photoinduced electron transfer (PET) between DNA-Ag fluorescent nanoclusters (NCs) and G-quadruplex/hemin complexes, we present a sensitive label-free fluorescent sensor for P... | 25,150,781 | [
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Mental testing in the early twentieth century: internationalizing the mental testing story. | This article suggests a possible approach to analyzing the global history of intelligence testing in light of some recent work in the history of science and science studies. In particular, it uses work in metrology and subaltern studies to develop possible models for the dissemination, appropriation, and transformation... | 25,150,810 | [
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The role of central and peripheral muscle fatigue in postcancer fatigue: a randomized controlled trial. | Postcancer fatigue is a frequently occurring problem, impairing quality of life. Little is known about (neuro)physiological factors determining postcancer fatigue. It may be hypothesized that postcancer fatigue is characterized by low peripheral muscle fatigue and high central muscle fatigue. The aims of this study wer... | 25,150,812 | [
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The Notch γ-secretase inhibitor ameliorates kidney fibrosis via inhibition of TGF-β/Smad2/3 signaling pathway activation. | Kidney fibrosis is a common feature of chronic kidney disease (CKD). A recent study suggests that abnormal Notch signaling activation contributes to the development of renal fibrosis. However, the molecular mechanism that regulates this process remains unexplored. Unilateral ureteral obstruction (UUO) or sham-operated ... | 25,150,830 | [
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Asymmetric mRNA localization contributes to fidelity and sensitivity of spatially localized systems. | Although many proteins are localized after translation, asymmetric protein distribution is also achieved by translation after mRNA localization. Why are certain mRNA transported to a distal location and translated on-site? Here we undertake a systematic, genome-scale study of asymmetrically distributed protein and mRNA... | 25,150,862 | [
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Whole blood transcriptomic analysis to identify clinical biomarkers of drug response. | Since most immunological and hematological conditions might be expected to alter whole blood gene expression, its examination can lead to insights into disease processes, and biomarkers to assess molecular phenotypes, disease states, progression and response to therapy. In this chapter we describe collection and storag... | 25,150,865 | [
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Management of side effects in the personalized medicine era: chemotherapy-induced peripheral neuropathy. | Pharmacogenomics has been establishing itself as a powerful tool to predict individual response to treatment, in order to personalize therapy management; this field has been explored in particular in Oncology. Not only efficacy on the malignant disease has been investigated, but also the possibility to predict adverse ... | 25,150,874 | [
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Specificity of emotion regulation difficulties related to anxiety in early adolescence. | Etiological models identify difficulties in emotion regulation as potential contributors to the development and maintenance of anxiety. To date, studies with adolescents have not tested whether different types of anxiety symptoms are related to different emotion regulation difficulties. The current study aimed to exami... | 25,150,890 | [
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High-affinity GABA uptake by neuronal GAT1 transporters provokes release of [(3)H]GABA by homoexchange and through GAT1-independent Ca(2+)-mediated mechanisms. | High-affinity uptake of GABA into nerve terminals may have functions other than recapture of the neurotransmitter. Synaptosomes purified from mouse cerebellum were prelabelled with [(3)H]GABA and then superfused with GABA and drugs selective for some presynaptic targets. Influx of GABA through GAT1 transporters stimula... | 25,150,942 | [
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Health status and fatigue of postpartum anemic women: a prospective cohort study. | The incidence of postpartum anemia is high. Current therapy consists of iron supplementation or blood transfusions, based on the assumption that these treatments improve health status (HS) and reduce fatigue. The aim of this study was to compare HS and fatigue in postpartum women with and without anemia. This prospecti... | 25,150,948 | [
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Evaluation of pesticide toxicity at their field recommended doses to honeybees, Apis cerana and A. mellifera through laboratory, semi-field and field studies. | A series of experiments were carried out to determine the acute toxicity of pesticides in the laboratory, toxicity through spray on flowering plants of mustard (Tier II evaluation) and field on both Apis cerana and A. mellifera bees. The overall mortality of honey bees through topical (direct contact) were found signif... | 25,150,969 | [
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T cell isolation from mouse kidneys. | The kidneys contain very few lymphocytes under homeostatic conditions. One kidney from a healthy mouse per average contains only 1-5 × 10(3) CD4(+) T cells. In immune-mediated kidney disease, γδ T cells, NKT cells, CD4(+) T cells, CD8(+) T cells, and regulatory T cells (Treg) infiltrate the kidney. Their numbers and su... | 25,150,994 | [
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In vitro generation of microbe-specific human Th17 cells. | Th17 cells represent a T helper cell subset with major implications for the pathogenesis of autoimmune diseases and the clearance of extracellular bacteria and fungi. The in vitro generation of human Th17 cells has been subject to many debates concerning the minimal cytokine requirements for IL-17 induction. This is pa... | 25,151,000 | [
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Mouse models of allergic airway disease. | In the last decades there has been a substantial increase in the prevalence of allergic diseases such as asthma. Hence there is a basic necessity to investigate disease mechanisms of allergic disorders and to trace novel treatment approaches. Indeed, allergic asthma is a disorder which is characterized by airway inflam... | 25,151,003 | [
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Induction of colitis in mice (T-cell transfer model). | Animal model of intestinal inflammation is essential for the understanding of the pathomechanisms of inflammatory bowel diseases like Crohn's disease and ulcerative colitis. Typically, naïve T-cells were transferred into immunocompromised mice and develop gut inflammation because of inappropriate downregulation. Here, ... | 25,151,004 | [
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Inflammatory biomarkers and bladder cancer prognosis: a systematic review. | Host immune response has an impact on tumour development and progression. There is interest in the use of inflammatory biomarkers (InfBMs) in cancer care. Although several studies assessing the potential prognostic value of InfBMs in cancer have been published in the past decades, they have had no impact on the managem... | 25,151,017 | [
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Coupling of comprehensive two-dimensional gas chromatography with quadrupole mass spectrometry: application to the identification of atmospheric volatile organic compounds. | Observation data of atmospheric volatile organic compounds (VOCs) are highly needed in air quality assessment, photochemical mechanism study, and emission control policy-making, while it has been a challenge to accurately and comprehensively measure them. Comprehensive two-dimensional gas chromatography (GC×GC) is one ... | 25,151,040 | [
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Coming of age: orphan genes in plants. | Sizable minorities of protein-coding genes from every sequenced eukaryotic and prokaryotic genome are unique to the species. These so-called ‘orphan genes’ may evolve de novo from non-coding sequence or be derived from older coding material. They are often associated with environmental stress responses and species-spec... | 25,151,064 | [
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Cadmium recovery by coupling double microbial fuel cells. | Cr(VI)-MFC of the double microbial fuel cell (d-MFC) arrangement could successfully complement the insufficient voltage and power needed to recover cadmium metal from Cd(II)-MFC, which operated as a redox-flow battery. It was also possible to drain electrical energy from the d-MFC by an additional passage. The highest ... | 25,151,082 | [
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Blood donation fears inventory: development and validation of a measure of fear specific to the blood donation setting. | Although individual differences in fear of stimuli related to blood donation is a key determinant of donor recruitment and retention, a donation-specific fear measure has yet to be developed. A donation-related fear measure was developed and tested on an initial sample of donors and non-donors, and then re-evaluated on... | 25,151,096 | [
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Public willingness to pay for CO2 mitigation and the determinants under climate change: a case study of Suzhou, China. | This study explored the factors that influence respondents' willingness to pay (WTP) for CO2 mitigation under climate change. A questionnaire survey combined with contingent valuation and psychometric paradigm methods were conducted in the city of Suzhou, Jiangsu Province in China. Respondents' traditional demographic ... | 25,151,109 | [
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An investigation of the molecular mechanisms engaged before and after the development of Alzheimer disease neuropathology in Down syndrome: a proteomics approach. | Down syndrome (DS) is one of the most common causes of intellectual disability, owing to trisomy of all or part of chromosome 21. DS is also associated with the development of Alzheimer disease (AD) neuropathology after the age of 40 years. To better clarify the cellular and metabolic pathways that could contribute to ... | 25,151,119 | [
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Nicotine mediates oxidative stress and apoptosis through cross talk between NOX1 and Bcl-2 in lung epithelial cells. | Nicotine contributes to the onset and progression of several pulmonary diseases. Among the various pathophysiological mechanisms triggered by nicotine, oxidative stress and cell death are reported in several cell types. We found that chronic exposure to nicotine (48h) induced NOX1-dependent oxidative stress and apoptos... | 25,151,121 | [
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Complete resection of a giant mediastinal teratoma occupying the entire right hemithorax in a 14-year-old boy. | Mature teratomas are the most common histological type of germ cell tumors. A 14-year-old boy was referred to our hospital with a giant mature teratoma occupying the entire right hemithorax compressed the superior vena cava (SVC) and total atelectasis of the right lung. He was misdiagnosed as malignant teratoma by a fi... | 25,151,139 | [
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Evolving possible link between PI3K and NO pathways in neuroprotective mechanism of ischemic postconditioning in mice. | The present study was conducted to pharmacologically investigate the influence of NO signaling pathway in PI3K mediated neuroprotective mechanism of ischemic postconditioning (iPoCo). Bilateral carotid artery occlusion (BCAO) of 12 min followed by reperfusion for 24 h was employed to produce ischemia/reperfusion-induce... | 25,151,147 | [
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Discovery and classification of homeobox genes in animal genomes. | The diversification of homeobox genes is of great interest to evolutionary and developmental biology. To generate a catalogue of all homeobox genes within species of interest, it is necessary to sequence complete genomes. It is now possible for small research projects and individual laboratories to determine near-compl... | 25,151,154 | [
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How to study HOX gene expression and function in mammalian oocytes and early embryos. | Mammalian oocytes and early embryos have unique characteristics and can only be obtained in small amounts. As a consequence, the techniques to be used to characterize gene expression and function have to be adapted. It is also important to keep in mind that differences exist between mammalian species. Here we describe ... | 25,151,155 | [
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Ertapenem prophylaxis of surgical site infections in elective colorectal surgery in China: a multicentre, randomized, double-blind, active-controlled study. | Our purpose was to evaluate ertapenem versus ceftriaxone/metronidazole for prophylaxis of surgical site infections (SSIs) following elective colorectal surgery in Chinese adult patients. Eligible Chinese adults aged 18-80 years scheduled to undergo elective colorectal surgery by laparotomy were randomized to receive a ... | 25,151,205 | [
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A revised model of ex-vivo reduction of hexavalent chromium in human and rodent gastric juices. | Chronic oral exposure to hexavalent chromium (Cr-VI) in drinking water has been shown to induce tumors in the mouse gastrointestinal (GI) tract and rat oral cavity. The same is not true for trivalent chromium (Cr-III). Thus reduction of Cr-VI to Cr-III in gastric juices is considered a protective mechanism, and it has ... | 25,151,221 | [
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Modeling the drugs' passive transfer in the body based on their chromatographic behavior. | One of the most challenging aims in modern analytical chemistry and pharmaceutical analysis is to create models for drugs' behavior based on simulation experiments. Since drugs' effects are closely related to their molecular properties, numerous characteristics of drugs are used in order to acquire a model of passive a... | 25,151,230 | [
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Modified ensemble Kalman filter for nuclear accident atmospheric dispersion: prediction improved and source estimated. | Atmospheric dispersion models play an important role in nuclear power plant accident management. A reliable estimation of radioactive material distribution in short range (about 50 km) is in urgent need for population sheltering and evacuation planning. However, the meteorological data and the source term which greatly... | 25,151,237 | [
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A greater proportion of liver transplant candidates have colorectal neoplasia than in the healthy screening population. | Various types of liver disease are associated with an increased prevalence of colorectal adenomas. We investigated whether cirrhosis is a risk factor for colorectal neoplasia by analyzing colonoscopy findings from 2 cohorts of patients awaiting liver transplantation. We performed a retrospective analysis to compare fin... | 25,151,257 | [
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Dietary acid load and chronic kidney disease among adults in the United States. | Diet can markedly affect acid-base status and it significantly influences chronic kidney disease (CKD) and its progression. The relationship of dietary acid load (DAL) and CKD has not been assessed on a population level. We examined the association of estimated net acid excretion (NAE(es)) with CKD; and socio-demograph... | 25,151,260 | [
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Gamma-range synchronization of fast-spiking interneurons can enhance detection of tactile stimuli. | We tested the sensory impact of repeated synchronization of fast-spiking interneurons (FS), an activity pattern thought to underlie neocortical gamma oscillations. We optogenetically drove 'FS-gamma' while mice detected naturalistic vibrissal stimuli and found enhanced detection of less salient stimuli and impaired det... | 25,151,266 | [
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Evolution in functionality of a metastatic pancreatic neuroendocrine tumour (pNET) causing Cushing's syndrome: treatment response with chemotherapy. | We report the case of a patient who had a non-functional metastatic pancreatic neuroendocrine tumour (pNET), which changed in functionality during the course of the disease. This case demonstrates the effectiveness of conventional cytotoxic chemotherapy in the management of select group of patients with this rare, chal... | 25,151,270 | [
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Left ventricular remodelling in aortic stenosis. | Aortic stenosis (AS) is a progressive condition associated with high mortality if not treated. The hemodynamic effects of AS have serious implications for the left ventricle. In this review, we describe the responses of the left ventricle to AS by highlighting the process of adaptive remodelling, which begins as a bene... | 25,151,283 | [
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Tumor cell dissemination to the bone marrow and blood is associated with poor outcome in patients with metastatic breast cancer. | The purpose of this study was to assess the impact of disseminated tumor cells (DTCs) on progression-free and overall survival (OS) in patients with metastatic breast cancer (MBC) and to compare it to simultaneous detection of circulating tumor cells (CTCs) from the blood in a subgroup. Disseminated tumor cells were id... | 25,151,295 | [
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Role of calpain-1 in the early phase of experimental ALS. | Elevation in [Ca(2+)]i and activation of calpain-1 occur in central nervous system of SOD1(G93A) transgenic mice model of amyotrophic lateral sclerosis (ALS), but few data are available about the early stage of ALS. We here investigated the level of activation of the Ca(2+)-dependent protease calpain-1 in spinal cord o... | 25,151,305 | [
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A meta-analysis of randomized trials of telmisartan versus active controls for insulin resistance in hypertensive patients. | To determine whether telmisartan improves insulin resistance compared with other antihypertensive drugs, we performed a meta-analysis of randomized controlled trials (RCTs) of telmisartan. MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials were searched through December 2013. Eligible studies were ... | 25,151,319 | [
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Illusions of truths in the Symplicity HTN-3 trial: generic design strengths but neuroscience failings. | The Achilles heel in catheter-based studies of renal denervation for severe hypertension is the almost universal failure to apply a confirmatory test for renal denervation. When renal denervation efficacy was assessed, using measurements of the spillover of norepinephrine from the renal sympathetic nerves to plasma, th... | 25,151,320 | [
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0.2213696,
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0.09987937,
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Analysis of combined detection of N-terminal pro-B-type natriuretic peptide and left ventricular ejection fraction in heart function in patients with acute CO poisoning. | N-terminal pro-B-type natriuretic peptide (NT-proBNP) has been used in the evaluation on heart function in many heart diseases. However, little is known in patients with acute carbon monoxide poisoning (ACOP). Left ventricular ejection fraction (LVEF) can be applied as a preliminary test method to measure the left vent... | 25,151,325 | [
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Tracheal intubation difficulties in the setting of face and neck burns: myth or reality? | Face and/or neck burn (FNB) exposes patients to the double respiratory risk of obstruction and hypoxia, and these risks may require a tracheal intubation. This study aims to describe the incidence and the characteristics of difficult intubation in FNB patients. We conducted a 5-year retrospective, single-center study i... | 25,151,328 | [
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Metabolic profiling of Gynostemma pentaphyllum extract in rat serum, urine and faeces after oral administration. | Folk drug Gynostemma pentaphyllum (Thunb.) Makino contains many biologically active phytochemicals which have been demonstrated to be effective against chronic diseases. As in vivo anti-tumor experiments of G. pentaphyllum extract (GP) show much stronger antitumor activities than in vitro, it is important and necessary... | 25,151,329 | [
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Gangliosides and cell surface ganglioside glycohydrolases in the nervous system. | Gangliosides are a large group of complex lipids found predominantly on the outer layer of the plasma membranes of cells, and they are particularly concentrated in nerve endings. Their half-life in the nervous system is short, and their membrane composition and content are strictly connected to their metabolism. Their ... | 25,151,381 | [
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Role of galactosylceramide and sulfatide in oligodendrocytes and CNS myelin: formation of a glycosynapse. | The two major glycosphingolipids of myelin, galactosylceramide (GalC) and sulfatide (SGC), interact with each other by trans carbohydrate-carbohydrate interactions in vitro. They face each other in the apposed extracellular surfaces of the multilayered myelin sheath produced by oligodendrocytes and could also contact e... | 25,151,383 | [
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Roles of carbohydrates in the interaction of pathogens with neural cells. | Numerous pathogens that can affect neural function utilize oligosaccharide-protein interactions as a first step in the infection process. The variability in carbohydrate structures as well as the presence of carbohydrate binding receptors on the surface of cells provides a plethora of potential binding sites for viruse... | 25,151,389 | [
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N-glycosylation in regulation of the nervous system. | Protein N-glycosylation can influence the nervous system in a variety of ways by affecting functions of glycoproteins involved in nervous system development and physiology. The importance of N-glycans for different aspects of neural development has been well documented. For example, some N-linked carbohydrate structure... | 25,151,388 | [
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Galectins and neuroinflammation. | Galectins, β-galactoside-binding lectins, play multiple roles in the regulation of immune and inflammatory responses. The major galectins expressed in the CNS are galectins 1, 3, 4, 8, and 9. Under normal physiological conditions, galectins maintain CNS homeostasis by participating in neuronal myelination, neuronal ste... | 25,151,395 | [
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Glycoconjugates and neuroimmunological diseases. | A wide range of neuroimmunological diseases affect the central and peripheral nervous systems. These disorders are caused by autoimmune attack directed against structurally and functionally diverse nervous system antigens. One such category comprises peripheral nervous system (PNS) diseases, termed peripheral neuropath... | 25,151,396 | [
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An alternative measurement tool for the identification of hysteretic responses in biological joints. | In structural engineering, sophisticated multi-dimensional analysis techniques, such as the Restoring Force Method (RFM), have been established for complex, nonlinear hysteretic systems. The purpose of the present study was to apply the RFM to quantify nonlinear spine hysteresis responses under applied moments. First, ... | 25,151,448 | [
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Agrin requires specific proteins to selectively activate γ-aminobutyric acid neurons for pain suppression. | Agrin, a heparan sulfate proteoglycan functioning as a neuro-muscular junction inducer, has been shown to inhibit neuropathic pain in sciatic nerve injury rat models, via phosphorylation of N-Methyl-d-aspartate receptor NR1 subunits in gamma-aminobutyric acid neurons. However, its effects on spinal cord injury-induced ... | 25,151,458 | [
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Sometimes it hurts when supervisors don't listen: the antecedents and consequences of safety voice among young workers. | We examined the relationship among having ideas about how to improve occupational safety, speaking up about them (safety voice), and future work-related injuries. One hundred fifty-five employed teenagers completed 3 surveys with a 1-month lag between each survey. We found that participants who were more likely to have... | 25,151,463 | [
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Mutation of the mitochondrial large ribosomal RNA can provide pentamidine resistance to Saccharomyces cerevisiae. | Pentamidine is used to treat several trypanosomal diseases, as well as opportunistic infection by pathogenic fungi. However, the relevant targets of this drug are unknown. We isolated dominant mutations providing pentamidine resistance to Saccharomyces cerevisiae, one of which was localized to mitochondrial DNA. Next-g... | 25,151,477 | [
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Is age associated with risk of malignancy in thyroid cancer? | Many predictive models for risk of malignancy in well-differentiated thyroid cancer (WDTC) have been proposed, and many scoring systems for thyroid cancer prognosis have been established. Age is taken in consideration in all. Our main goal is to establish whether patients' age has a correlation with the rate of maligna... | 25,151,485 | [
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OSL and photo-transferred TL of quartz single crystals sensitized by high-dose of gamma-radiation and moderate heat-treatments. | This study investigates the optically stimulated luminescence (OSL) and the photo-transferred thermoluminescence (PTTL) signals in quartz single crystals showing a strong TL peak near 300°C after being sensitized by irradiation with 25kGy of gamma rays and heating at 400°C. Natural and sensitized samples were prepared ... | 25,151,496 | [
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Social disorder, physical activity and adiposity in Mexican adults: evidence from a longitudinal study. | This study analyzed the prospective relationship of community social disorder with sedentary behavior, sport participation, and adiposity in Mexican adults from the National Mexican Family Life Survey (MxFLS). The sample included 8307 adults (aged ≥20 years) from 145 communities. During a three-year follow-up, particip... | 25,151,499 | [
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Symptoms and medication management in the end of life phase of high-grade glioma patients. | During the end of life (EOL) phase of high-grade glioma (HGG) patients, care is primarily aimed at reducing symptom burden while maintaining quality of life as long as possible. In this study, we evaluated the prevalence of symptoms and medication management in HGG patients during the EOL phase. We analyzed disease-spe... | 25,151,506 | [
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A content and structural assessment of oxidative motifs across a diverse set of life forms. | Exposure to weightlessness (microgravity) or other protein stresses are detrimental to animal and human protein tissue health. Protein damage has been associated with stress and is linked to aging and the onset of diseases such as Alzheimer׳s, Parkinson׳s, sepsis, and others. Protein stresses may cause alterations to p... | 25,151,511 | [
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Deformable image registration for adaptive radiation therapy of head and neck cancer: accuracy and precision in the presence of tumor changes. | To compare deformable image registration (DIR) accuracy and precision for normal and tumor tissues in head and neck cancer patients during the course of radiation therapy (RT). Thirteen patients with oropharyngeal tumors, who underwent submucosal implantation of small gold markers (average 6, range 4-10) around the tum... | 25,151,537 | [
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Establishing high-quality prostate brachytherapy using a phantom simulator training program. | To design and implement a unique training program that uses a phantom-based simulator to teach the process of prostate brachytherapy (PB) quality assurance and improve the quality of education. Trainees in our simulator program were practicing radiation oncologists, radiation oncology residents, and fellows of the Amer... | 25,151,539 | [
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Statistical modeling of CTV motion and deformation for IMRT of early-stage rectal cancer. | To derive and validate a statistical model of motion and deformation for the clinical target volume (CTV) of early-stage rectal cancer patients. For 16 patients, 4 to 5 magnetic resonance images (MRI) were acquired before each fraction was administered. The CTV was delineated on each MRI. Using a leave-one-out methodol... | 25,151,540 | [
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Factors relating to the perceived management of emergency situations: a survey of former Advanced Life Support course participants' clinical experiences. | This study explored individual, team, and setting factors associated with the quality of management of in-hospital emergency situations experienced by former Advanced Life Support (ALS) course participants. This study was a survey of former ALS course participants' long-term experience of management of in-hospital, eme... | 25,151,548 | [
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Performing under pressure: quiet eye training improves surgical knot-tying performance. | We examined the effectiveness of traditional technical training (TT) and quiet eye training (QET) on the performance of 1-handed square knot tying among first-year surgery residents under normal and high-anxiety conditions. Twenty surgery residents were assigned randomly to 1 of 2 groups and completed pretest, training... | 25,151,552 | [
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Global epidemiology of HIV. | The number of persons living with HIV worldwide reached approximately 35.3 million in 2012. Meanwhile, AIDS-related deaths and new HIV infections have declined. Much of the increase in HIV prevalence is from rapidly increasing numbers of people on antiretroviral treatment who are now living longer. There is regional va... | 25,151,559 | [
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Cost-effectiveness of insulin glargine versus sitagliptin in insulin-naïve patients with type 2 diabetes mellitus. | In the EASIE (Evaluation of Insulin Glargine Versus Sitagliptin in Insulin-Naïve Patients) trial, insulin glargine found a significant reduction in glycosylated hemoglobin compared with sitagliptin in patients with type 2 diabetes who are inadequately controlled with metformin. The objective of this study was to assess... | 25,151,573 | [
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Assessment of the effective dose in supine, prone, and oblique positions in the maxillofacial region using a novel combined extremity and maxillofacial cone beam computed tomography scanner. | The objectives of this study were to assess the organ and effective doses (International Commission on Radiological Protection [ICRP] 103 standard) resulting from supine, prone, and oblique phantom positions in the maxillofacial region using a novel cone beam computed tomography (CBCT) device and to compare the results... | 25,151,590 | [
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Mechanisms underlying sleep-wake disturbances in alcoholism: focus on the cholinergic pedunculopontine tegmentum. | Sleep-wake (S-W) disturbances are frequently associated with alcohol use disorders (AUD), occurring during periods of active drinking, withdrawal, and abstinence. These S-W disturbances can persist after months or even years of abstinence, suggesting that chronic alcohol consumption may have enduring negative effects o... | 25,151,622 | [
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Tailored atrial substrate modification based on low-voltage areas in catheter ablation of atrial fibrillation. | Reduced electrogram amplitude has been shown to correlate with diseased myocardium. We describe a novel individualized approach for catheter ablation of atrial fibrillation (AF) based on low-voltage areas (LVAs) in the left atrium (LA). We sought to assess (1) the incidence of LVAs in patients undergoing AF catheter ab... | 25,151,631 | [
-0.145332,
0.3393214,
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0.005608059,
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... |
Multimeric states of starch phosphorylase determine protein-protein interactions with starch biosynthetic enzymes in amyloplasts. | Protein-protein interactions between starch phosphorylase (SP) and other starch biosynthetic enzymes were investigated using isolated maize endosperm amyloplasts and a recombinant maize enzyme. Plastidial SP is a stromal enzyme existing as a multimeric protein in amyloplasts. Biochemical analysis of the recombinant mai... | 25,151,633 | [
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0.0379347... |
Vitamin K antagonists and cognitive impairment: results from a cross-sectional pilot study among geriatric patients. | Vitamin K is involved in brain physiology, suggesting that its deficiency induces cognitive decline. Our objective was to determine whether using vitamin K antagonists (VKAs) was associated with cognitive impairment among geriatric patients. Two hundred sixty-seven older patients (mean, 83.4 ± 8.1 years; 56.9% female) ... | 25,151,653 | [
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0.2731412,
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0.1980751,
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... |
Identification of fluoride contamination with the interaction of physico-chemical characteristics in groundwater of Jodhpur (India). | A hydrogeochemical investigation has been carried out in Jodhpur district of western Rajasthan in India. The investigated area has been classified into four types with reference to concentration of F(-) prescribed for drinking: low-F(-) (< 1.0 mgl(-1)), moderate-F(-) (1.0-1.50 mgl(-1)) , high-F(-) (1.5-3.0 mgl-(1)) ... | 25,151,715 | [
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0.22... |
Noise monitoring and modeling on four lanning of national highways corridor. | Noise emitted from traffic contributes to about 55% of total noise pollution in India. This paper is an effort of a research conducted to quantify and analyze the traffic noise emissions along the Salem-Namakkal NH 7 corridor with an ultimate objective of setting up a traffic noise model based on the traffic noise cond... | 25,151,718 | [
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Assessment of traffic noise at Kolar Gold Fields, India. | Traffic noise produces environmental problems on surroundings. At Kolar Gold Fields (KGF), traffic load at different locations can cause noise pollution. Therefore, a detailed study was carried out at KGF in commercial, residential and silence zone. Different monitoring locations were identified in these zones and A-we... | 25,151,719 | [
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0.18114... |
[A novel HIF-1 inhibitor--manassantin A derivative LXY6099 inhibits tumor growth]. | Hypoxia-inducible factor-1 (HIF-1) is a key transcription factor on hypoxia responses in mammalian tissues. HIF-1 plays as a positive factor in solid tumor and leads to hypoxia-driven responses that enhance its downstream gene expression for tumor growth and survival. LXY6099 was obtained by the structural modification... | 25,151,731 | [
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0.01709981,
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0.189231,
0.3300888,
0.1154279,
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0.20... |
[The impurity profiling of simvastatin and its tablets by UPLC-MS/MS]. | Investigation of simvastatin and its related substances was carried out using a reversed phase ultra performance liquid chromatography/tandem mass spectrometry method. The identification of impurities in simvastatin was performed with a triple-quadrupole mass spectrometer, with an electrospray ionization (ESI) source i... | 25,151,740 | [
-0.3286382,
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0.2182403,
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0.0785128,
0.1124218,
0.001097819,
-0.2229378,
... |
[Vitro study on gene transfection efficiency of hyaluronic acid modified core-shell liponanoparticles in human retinal pigment epithelium cells]. | The aim of this study is to prepare hyaluronic acid (HA) modified core-shell liponanoparticles (pHA-LCS-NPs) as gene delivery system and investigate its gene transfection efficiency in human retinal pigment epithelium (ARPE-19) cells in vitro. The pHA-LCS-NPs was prepared by firstly hydrating dry lipid film with CS-NPs... | 25,151,745 | [
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0.3896602,
0.1224812,
0.2741424,
0.4617007,
-0.09943416,
-0.46... |
[Antitumor efficacy of irinotecan-loaded galactosyl modified lipid bilayer-coated mesoporous silica nanoparticles against hepatocellular carcinoma cells]. | The purpose of this study is to prepare galactosyl modified lipid bilayer-coated mesoporous silica nanoparticles (GPEM) to enhance the antitumor efficacy against hepatocellular carcinoma cells. The irinotecan (CPT-11) loaded mesoporous silica nanoparticles (MSNs) was coated with the Gal-P123 modified functional lipid b... | 25,151,746 | [
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0.01429785,
0.1032558,
0.3526078,
0.3179229,
0.3994158,
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0.2... |
[Surveillance report of drug-resistant bacteria from 2007 to 2012 in Saga Prefecture, Japan (the second report)]. | Drug-resistant bacteria are a problematic issue in Japan. Surveillance of drug-resistant bacteria is important because the frequency of isolation and kinds of such bacteria vary between hospitals and local areas. This study summarizes the results of detection of drug-resistant bacteria in Saga Prefecture from July 2007... | 25,151,773 | [
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0.03487752,
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[A 10-year retrospective--from the achievement of ISO 15189 accreditation toward the next stage--chairman's introductory remarks]. | More than 10 years have passed since ISO 15189 was issued in February 2003, and ISO 15189:2012 (bilingual edition published in April 2013) was issued in November 2012. In order to provide useful laboratory services, standardizing examination results performed by medical laboratories is very important. The accreditation... | 25,151,781 | [
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0.2686739,
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0.1181611,
0.1897295,
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[Update to ISO 15189:2012, and future prospects]. | ISO (the International Organization for Standardization) is a worldwide federation of national standard bodies (ISO member bodies). The work of preparing international standards is normally carried out through ISO technical committees. ISO 15189 was prepared by Technical Committee ISO/TC 212, clinical laboratory testin... | 25,151,783 | [
-0.4621444,
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0.006837834,
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0.2895471,
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0.1814484,
0.1032918,
0.1997804,
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... |
Genetic diversity of Mycosphaerella graminicola isolates from a single field. | Septoria tritici blotch caused by Mycosphaerella graminicola is currently one of the most economically damaging diseases on wheat crops worldwide. Two hundred and sixty single-conidial isolates of this fungus were sampled in April 2012 in the Nord-Pas de Calais region (France). They have all been collected from 13 dist... | 25,151,819 | [
-0.143924,
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0.06219923,
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0.1923106,
0.4932386,
0.6094734,
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... |
Quantifying the non-fungicidal effects of foliar applications of fluxapyroxad (Xemium) on stomatal conductance, water use efficiency and yield in winter wheat. | The active ingredient fluxapyroxad belongs to the chemical group of carboxamides and is a new generation succinate dehydrogenase inhibitor (SDHI) in complex II of the mitochondrial respiratory chain. It has strong efficacy against the key foliar diseases of winter wheat in the UK: Septoria leaf blotch, yellow stripe ru... | 25,151,827 | [
-0.05742041,
0.2157409,
0.2899678,
0.16901,
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0.2294957,
0.2019884,
0.4273206,
0.0781353,
0.2... |
Silky bent grass resistance to herbicides: one year of monitoring in Belgium. | Silky bent grass (Apera spica-venti (L.) P. Beauv.) is a common weed of cereal crops widely spread in Northern and Easthern Europe (Germany, Czech Republic,...), Northern Asia, Siberia and Canada. Up to now, no resistant case has been detected in Belgium but some chemical weeding failures have been observed in Wallonia... | 25,151,844 | [
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0.2005917,
0.3984588,
0.3128052,
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0.17... |
Fragment-based docking: development of the CHARMMing Web user interface as a platform for computer-aided drug design. | Web-based user interfaces to scientific applications are important tools that allow researchers to utilize a broad range of software packages with just an Internet connection and a browser. One such interface, CHARMMing (CHARMM interface and graphics), facilitates access to the powerful and widely used molecular softwa... | 25,151,852 | [
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0.2446558,
0.03849515,
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0.1081954,
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... |
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