title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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pH-sensitive carbonate apatite nanoparticles as DNA vaccine carriers enhance humoral and cellular immunity. | To demonstrate the potential of pH-sensitive carbonate apatite (CO₃Ap) nanoparticles as DNA vaccine carriers to enhance vaccination efficacy, we examined the humoral and cellular immune responses of C57BL/6 mice immunized with the plasmid expression vector pCI-neo encoding the full-length soluble ovalbumin (OVA) (pCI-n... | 25,261,380 | [
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Intraocular pressure profiles during femtosecond laser-assisted cataract surgery. | To document the intraocular pressure (IOP) profiles during femtosecond laser-assisted cataract surgery. Refractive cataract surgery center. Prospective case series. Intraocular pressure was measured using a handheld portable applanation tonometer (Tono-Pen Avia) during femtosecond laser-assisted cataract surgery using ... | 25,261,391 | [
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GPAC-genome presence/absence compiler: a web application to comparatively visualize multiple genome-level changes. | Our understanding of genome-wide and comparative sequence information has been broadened considerably by the databases available from the University of California Santa Cruz (UCSC) Genome Bioinformatics Department. In particular, the identification and visualization of genomic sequences, present in some species but abs... | 25,261,406 | [
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In vitro selection of mutants resistant to ozenoxacin compared with levofloxacin and ciprofloxacin in Gram-positive cocci. | To determine the frequency of selecting mutants resistant to ozenoxacin, a des-fluoro-(6)-quinolone active against pathogens involved in skin and skin structure infections, compared with levofloxacin and ciprofloxacin in quinolone-susceptible and -resistant Gram-positive cocci. Forty-nine quinolone-susceptible and -res... | 25,261,416 | [
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The spread of carbapenemase-producing bacteria in Africa: a systematic review. | Carbapenems are the last line of defence against ever more prevalent MDR Gram-negative bacteria, but their efficacy is threatened worldwide by bacteria that produce carbapenemase enzymes. The epidemiology of bacteria producing carbapenemases has been described in considerable detail in Europe, North America and Asia; h... | 25,261,423 | [
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Investigation of hemorheological parameters in periodontal diseases. | Periodontal diseases are frequently associated with cardiovascular diseases (CVD). On the other hand, occurrence of CVD has also been related with increased blood viscosity. This study was planned to investigate four main hemorheological parameters contributing to blood viscosity - hematocrit, erythrocyte deformability... | 25,261,434 | [
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Hemorrhagic collision metastasis in a cerebral arteriovenous malformation. | A 26-year-old patient with recurrent choriocarcinoma of the testis presented with headache and progressive left homonymous hemianopsia. On initial MRI a grade 4 arteriovenous malformation (AVM) was identified in the right occipital lobe, which was further characterized by catheter angiography. Continued worsening of th... | 25,261,441 | [
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White matter hyperintensities as early and independent predictors of Alzheimer's disease risk. | There is growing evidence that vascular health plays a significant role in the etiology of clinical Alzheimer's disease (AD). Understanding the timing of vascular changes in relation to progression from cognitive impairment to AD has become of increasing importance, being both possible pre-clinical markers and potentia... | 25,261,452 | [
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Vascular hamartoma in the central nervous system of a foal. | Vascular hamartomas are non-neoplastic developmental anomalies of vessels. Cases of cerebral vascular hamartomas have been previously reported in dogs and cats. A 4-week-old Freiberger foal had shown persistent problems with breathing and swallowing since birth, and bilateral laryngeal paralysis was diagnosed. The foal... | 25,261,460 | [
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IL-17A influences essential functions of the monocyte/macrophage lineage and is involved in advanced murine and human atherosclerosis. | Atherosclerosis is a chronic inflammatory disease. Lesion progression is primarily mediated by cells of the monocyte/macrophage lineage. IL-17A is a proinflammatory cytokine, which modulates immune cell trafficking and is involved inflammation in (auto)immune and infectious diseases. But the role of IL-17A still remain... | 25,261,478 | [
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Vizantin inhibits endotoxin-mediated immune responses via the TLR 4/MD-2 complex. | Vizantin has immunostimulating properties and anticancer activity. In this study, we investigated the molecular mechanism of immune activation by vizantin. THP-1 cells treated with small interfering RNA for TLR-4 abolished vizantin-induced macrophage activation processes such as chemokine release. In addition, compared... | 25,261,480 | [
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Dual role of the leukocyte integrin αMβ2 in angiogenesis. | Polymorphonuclear neutrophils (PMNs) and macrophages are crucial contributors to neovascularization, serving as a source of chemokines, growth factors, and proteases. α(M)β(2)(CD11b/CD18) and α(L)β(2)(CD11a/CD18) are expressed prominently and have been implicated in various responses of these cell types. Thus, we inves... | 25,261,488 | [
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Unrecognized preclinical Alzheimer disease confounds rs-fcMRI studies of normal aging. | To determine whether, and to what degree, preclinical Alzheimer disease (AD) confounds studies of healthy aging where "healthy" is based on cognitive normality alone. We examined the effects of preclinical AD in cognitively normal older individuals using resting-state functional connectivity MRI. We investigated 2 grou... | 25,261,500 | [
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Factors affecting the uptake and retention of Vibrio vulnificus in oysters. | Vibrio vulnificus, a bacterium ubiquitous in oysters and coastal water, is capable of causing ailments ranging from gastroenteritis to grievous wound infections or septicemia. The uptake of these bacteria into oysters is often examined in vitro by placing oysters in seawater amended with V. vulnificus. Multiple teams h... | 25,261,513 | [
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Hydroxycinnamic acids used as external acceptors of electrons: an energetic advantage for strictly heterofermentative lactic acid bacteria. | The metabolism of hydroxycinnamic acids by strictly heterofermentative lactic acid bacteria (19 strains) was investigated as a potential alternative energy route. Lactobacillus curvatus PE5 was the most tolerant to hydroxycinnamic acids, followed by strains of Weissella spp., Lactobacillus brevis, Lactobacillus ferment... | 25,261,518 | [
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Performance comparison of Illumina and ion torrent next-generation sequencing platforms for 16S rRNA-based bacterial community profiling. | High-throughput sequencing of the taxonomically informative 16S rRNA gene provides a powerful approach for exploring microbial diversity. Here we compare the performances of two common "benchtop" sequencing platforms, Illumina MiSeq and Ion Torrent Personal Genome Machine (PGM), for bacterial community profiling by 16S... | 25,261,520 | [
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Predictive markers of clinical outcome in the GRMD dog model of Duchenne muscular dystrophy. | In the translational process of developing innovative therapies for DMD (Duchenne muscular dystrophy), the last preclinical validation step is often carried out in the most relevant animal model of this human disease, namely the GRMD (Golden Retriever muscular dystrophy) dog. The disease in GRMD dogs mimics human DMD i... | 25,261,568 | [
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Patient preferences for psychological support in inflammatory arthritis: a multicentre survey. | Inflammatory arthritis (IA) can lead to anxiety, depression, pain and fatigue. Psychological support can improve quality of life and self-management; and European and American guidelines recommend support be offered. This study examined patient views on psychological support for their IA. A questionnaire designed by re... | 25,261,572 | [
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Biomarkers in dementia: clinical utility and new directions. | Imaging, cerebrospinal fluid (CSF) and blood-based biomarkers have the potential to improve the accuracy by which specific causes of dementia can be diagnosed in vivo, provide insights into the underlying pathophysiology, and may be used as inclusion criteria and outcome measures for clinical trials. While a number of ... | 25,261,571 | [
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Neutrophil extracellular traps regulate IL-1β-mediated inflammation in familial Mediterranean fever. | Inflammatory attacks of familial Mediterranean fever (FMF) are characterised by circulation and influx of high number of polymorphonuclear neutrophils (PMN) in the affected sites and profound therapeutic effect of IL-1β inhibitors. We investigated the role of neutrophil extracellular traps (NET) in the pathogenesis of ... | 25,261,578 | [
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Effects of triiodothyronine on turnover rate and metabolizing enzymes for thyroxine in thyroidectomized rats. | Previous studies in rats have indicated that surgical thyroidectomy represses turnover of serum thyroxine (T4). However, the mechanism of this process has not been identified. To clarify the mechanism, we studied adaptive variation of metabolic enzymes involved in T4 turnover. We compared serum T4 turnover rates in thy... | 25,261,596 | [
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Intrahepatic splenosis in a chronic hepatitis C patient with no history of splenic trauma mimicking hepatocellular carcinoma. | Intrahepatic splenosis (IHS) is the autotransplantation of splenic tissue that mostly develops after abdominal injury and is often misdiagnosed as hepatocellular carcinoma (HCC) because of similarities in radiological features. We had an opportunity to treat an extremely rare case of intrahepatic splenosis, which were ... | 25,261,602 | [
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High iron accumulation in hair and nail of people living in iron affected areas of Assam, India. | Human populace of Assam, India repeatedly exposed to high concentration of iron in groundwater results in adverse health effects like hemochromatosis, liver cirrhosis and siderosis. In the present study, human hair and nail analysis were carried out to establish a possible relationship between iron toxicity and its dep... | 25,261,608 | [
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A model to identify high crash road segments with the dynamic segmentation method. | Currently, high social and economic costs in addition to physical and mental consequences put road safety among most important issues. This paper aims at presenting a novel approach, capable of identifying the location as well as the length of high crash road segments. It focuses on the location of accidents occurred a... | 25,261,621 | [
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Silver, zinc oxide and titanium dioxide nanoparticle ecotoxicity to bioluminescent Pseudomonas putida in laboratory medium and artificial wastewater. | Bacteria based ecotoxicology assessment of manufactured nanoparticles is largely restricted to Escherichia coli bioreporters in laboratory media. Here, toxicity effects of model OECD nanoparticles (Ag NM-300K, ZnO NM-110 and TiO2 NM-104) were assessed using the switch-off luminescent Pseudomonas putida BS566::luxCDABE ... | 25,261,625 | [
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Three-dimensional ultrasonography for the prediction of breast cancer prognosis. | To determine the value of three-dimensional (3D) ultrasonography findings in the prediction of breast cancer prognosis. The findings of 3D ultrasonography of 221 breast tumors were compared with pathologic prognostic factors, including tumor diameter, axillary lymph node status, histologic grade, estrogen receptor (ER)... | 25,261,646 | [
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Knockdown of CETN1 inhibits breast cancer cells proliferation. | Breast cancer is a multifactorial disease and identification of the genes and proteins regulating breast carcinogenesis is critical in exploring novel targeted therapies. The aim of this study was to investigate the role CETN1 in breast cancer growth and metastasis. CETN1 expression levels were measured in breast tissu... | 25,261,648 | [
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The antitumor effect and mechanism of taipeinine A, a new C19-diterpenoid alkaloid from Aconitum taipeicum, on the HepG2 human hepatocellular carcinoma cell line. | To investigate whether taipeinine A (JNQ2), a C19-diterpenoid alkaloid prepared from the roots of Aconitum taipeicum, has anticancer effects on hepatocellular carcinoma (HCC) and to study its probable anticancer mechanisms. JNQ2 activities were assessed on human HCC cell line (HepG2) by proliferative assay, cell cycle ... | 25,261,656 | [
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Effects of TNFα on cell viability, proliferation and apoptosis of glioma cells U251. | To analyse the relationship between the expression of TNFα and the characteristics of glioma cell line U251. U251 cell line was transfected with overexpressed TNFα or depleted TNFα constructs. The cell viability, proliferation and apoptosis were determined with MTT assay and flow cytometry analysis. The expressions of ... | 25,261,660 | [
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Types of reactions to malignant disease in view of V.E. Frankl philosophy. | The purpose of this work was to find out whether there is interdependence between the patients- assessments of biological, psychological, psychosocial and spiritual levels. 590 subjects, both ill and healthy, were examined by appropriate means and asked to consider their level of fear, depression (Hospital Anxiety and ... | 25,261,670 | [
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Aggressive interventions in terminally ill patients with solid tumors in China: a retrospective single center analysis. | Overtreatment in terminally ill cancer patients is very common worldwide, but whether patients will benefit from aggressive care remains obscure. This study aimed to explore the value of aggressive interventions in the end of life in adult patients with advanced solid tumors. All adult patients who died from advanced s... | 25,261,672 | [
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Otto Hahn (1879-1968): pioneer in radiochemistry and discoverer of radiotherapeutic mesothorium. | Otto Hahn was a German innovative chemist. He had discovered various radioactive elements, as well as the nuclear fission. He finally received the Nobel Prize for his participation in the atomic energy project, which Hahn and others considered that could be a factor used for peaceful means like cheap electricity and ch... | 25,261,683 | [
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Aberrant CD200/CD200R1 expression and its potential role in Th17 cell differentiation, chemotaxis and osteoclastogenesis in rheumatoid arthritis. | CD200/CD200R1 signalling has an immunoregulatory effect on the activation threshold of the inflammatory immune response and maintains immune homeostasis. In this study we evaluated the status of CD200/CD200R1 interaction in patients with RA. The expression of CD200 and CD200R1 was examined by immunohistochemistry and f... | 25,261,692 | [
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In utero programming alters adult response to chronic mild stress: part 3 of a longitudinal study. | Exposure to stress before birth may lay the foundation for the development of sensitivities or protection from psychiatric disorders while later stress exposure may trigger either their expression or suppression. This report, part three of a longitudinal study conducted in our laboratory, aimed to examine the interacti... | 25,261,693 | [
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Effects of solvent on percutaneous absorption of nonvolatile lipophilic solute. | Understanding the effects of solvents upon percutaneous absorption can improve drug delivery across skin and allow better risk assessment of toxic compound exposure. The objective of the present study was to examine the effects of solvents upon the deposition of a moderately lipophilic solute at a low dose in the strat... | 25,261,711 | [
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Differential utilization and transformation of sulfur allotropes, μ-S and α-S8, by moderate thermoacidophile Sulfobacillus thermosulfidooxidans. | The utilization of amorphous μ-S and orthorhombic α-S8 by thermoacidophile Sulfobacillus thermosulfidooxidans was firstly investigated in terms of cell growth and sulfur oxidation behavior. The morphology and surface sulfur speciation transformation were evaluated by using scanning electron microscopy (SEM), X-ray diff... | 25,261,719 | [
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A quantitative model of the major pathways for radiation-induced DNA double-strand break repair. | We have developed a model approach to simulate the major pathways of DNA double-strand break (DSB) repair in mammalian and human cells. The proposed model shows a possible mechanistic explanation of the basic regularities of DSB processing through the non-homologous end-joining (NHEJ), homologous recombination (HR), si... | 25,261,728 | [
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Regional and tissue-specific differences in brain glutamate concentration measured by in vivo single voxel MRS. | There is growing interest in characterizing spatial distribution of glutamate (Glu) in brain disorders. Comparing the differences in Glu concentration using magnetic resonance spectroscopy (MRS) is hampered by the confounding effects of different anatomical regions and tissue composition. Effect of tissue composition o... | 25,261,738 | [
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Porous Ca-based bead sorbents for simultaneous removal of SO₂, fine particulate matters, and heavy metals from pilot plant sewage sludge incineration. | In this study, a porous calcium-based sorbent was prepared for simultaneous removal of SO2, particulate matter (PM), and heavy metals generated during incineration of sewage sludge. The prepared sorbent was confirmed to have a 3-dimensional-network pore structure, a high specific surface area of 68.5m(2)/g, and gas per... | 25,261,759 | [
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Does the oxysterol 27-hydroxycholesterol underlie Alzheimer's disease-Parkinson's disease overlap? | Alzheimer's disease (AD), the most common form of dementia, is characterized histopathologically by the deposition of β-amyloid (Aβ) plaques and neurofibrillary tangles-containing hyperphosphorylated tau protein in the brain. Parkinson's disease (PD), the most common movement disorder, is characterized by the aggregati... | 25,261,765 | [
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Lack of P16ink4a over expression in penile squamous cell carcinoma is associated with recurrence after lymph node dissection. | There have been conflicting data in studies on the prognostic role of high risk human papillomavirus in penile squamous cell carcinoma. Using P16(ink4a) over expression as a surrogate marker for high risk human papillomavirus, we evaluated high risk human papillomavirus status with respect to various clinical features,... | 25,261,804 | [
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Simultaneous monitoring of CMV and BKV by quantitative PCR in renal transplant recipients. | Polyomavirus (BKV) and cytomegalovirus (CMV) are associated with renal graft failure. The aim was to establish a quantitative PCR method (Q-PCR) to detect BKV and CMV simultaneously. The conserved sequences of BKV and CMV were amplified and cloned into the plasmids as standards. The sensitivity, specificity and the pre... | 25,261,811 | [
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Virtual ablation for atrial fibrillation in personalized in-silico three-dimensional left atrial modeling: comparison with clinical catheter ablation. | Although catheter ablation is an effective rhythm control strategy for atrial fibrillation (AF), empirically-based ablation has a substantial recurrence rate. The purposes of this study were to develop a computational platform for patient-specific virtual AF ablation and to compare the anti-fibrillatory effects of 5 di... | 25,261,813 | [
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Biomarker and stable carbon isotopic signatures for 100-200 year sediment record in the Chaihe catchment in southwest China. | Natural inputs and anthropogenic influences on lakes and their catchments are reflected in the sediment record. In the present study, the extractable organic compounds from sediments in the Chaihe catchment of the Dianchi watershed were analyzed to characterize source inputs. Results show that the sediments are dominat... | 25,261,816 | [
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Parental accommodation of child anxiety and related symptoms: range, impact, and correlates. | Parental accommodation--i.e., changes in parents' behavior in attempts to prevent or reduce child distress--has been most studied in relation to OCD. Although recent work suggests parents of children with non-OCD anxiety diagnoses also engage in accommodation, little is known about the specific forms, correlates, and a... | 25,261,837 | [
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A historical review of trauma-related diagnoses to reconsider the heterogeneity of PTSD. | Based on the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders, there are 636,120 ways for an individual to qualify for a diagnosis of posttraumatic stress disorder (PTSD) (Galatzer-Levy & Bryant, 2013). To unravel this heterogeneity, we examine the historical trajectory of trauma-related dia... | 25,261,838 | [
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Radon measurement of natural gas using alpha scintillation cells. | Due to their sensitivity and ease of use, alpha-scintillation cells are being increasingly utilized for measurements of radon ((222)Rn) in natural gas. Laboratory studies showed an average increase of 7.3% in the measurement efficiency of alpha-scintillation cells when filled with less-dense natural gas rather than reg... | 25,261,866 | [
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Hierarchical modeling of indoor radon concentration: how much do geology and building factors matter? | Radon is a natural gas known to be the main contributor to natural background radiation exposure and only second to smoking as major leading cause of lung cancer. The main concern is in indoor environments where the gas tends to accumulate and can reach high concentrations. The primary contributor of this gas into the ... | 25,261,869 | [
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Different HIV pox viral vector-based vaccines and adjuvants can induce unique antigen presenting cells that modulate CD8 T cell avidity. | The lung-derived dendritic cell (LDC) recruitment following intranasal (i.n.) vaccination of different poxviral vector-based vaccines/adjuvants were evaluated to decipher how these factors influenced CD8(+) T cell avidity. Compared to the standard i.n. recombinant fowlpox virus (FPV)-HIV vaccination, the FPV-HIV IL-13R... | 25,261,870 | [
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Gluten sensitivity: new epidemic or new myth? Every major change in our diet carries with it the possibility of unforeseen risks. | Fueled in part by recent best-selling books that warn of the evils of gluten in our diets, a significant proportion of our population is now either avoiding foods that contain gluten or eliminating gluten entirely from their diets, and these numbers continue to grow. The gluten-free trend-and the accompanying multibill... | 25,261,874 | [
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Cardiorespiratory fitness, body mass index, and cancer mortality: a cohort study of Japanese men. | The aim of this study is to investigate the independent and joint effects of cardiorespiratory fitness (CRF) and body mass index (BMI) on cancer mortality in a low body mass index population. We evaluated CRF and BMI in relation to cancer mortality in 8760 Japanese men. The median BMI was 22.6 kg/m2 (IQR: 21.0-24.3). T... | 25,261,876 | [
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Suppression of Smad-1 mRNA expression level by Smad-2 likely control dichotomy of NF-κB and Smads mediated activation. | The aim of this study was to find out how NF-κB and Smad-mediated signaling influenced the expression of astrogliogenic versus neurogenic markers of brain development in U4C cells which were either enriched (Tg Jak-1) or deprived in Jak-1 molecule (Jak-1 KO). Genetically modified U4C cells were transfected with NF-kB r... | 25,261,891 | [
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The comparison of miR-155 with computed tomography and computed tomography plus serum amyloid A protein in staging rectal cancer. | Recently identified class of microRNAs (miRNAs) provided a new insight in cancer research. As a member of miRNAs family, miR-155 expression demonstrated the correlation with tumor stage. Thus, its expression level can be potentially used for staging rectal tumors. The aim of this study was to systematically evaluate th... | 25,261,908 | [
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Physical characteristics that predict final basal insulin dose in type 2 diabetes mellitus, with a special focus on BMI. | The possibility to predict final insulin dose based on patient's characteristics would allow for efficient titration for patients with higher dose needs. The primary aim of this post-hoc analysis of the L2T3 study was to determine predictors for final dose. Specifically, we focused on the relationship between BMI and d... | 25,261,909 | [
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Natural and synthetic selenoproteins. | Once considered highly toxic, the element selenium is now recognized as a micronutrient essential for human health. It is inserted co-translationally into many proteins as the non-canonical amino acid selenocysteine, providing the resulting selenoprotein molecules with a range of valuable redox properties; selenocystei... | 25,261,915 | [
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0.4563372,
0.05286533,
-... |
An EEG/ERP investigation of the development of empathy in early and middle childhood. | Empathic arousal is the first ontogenetic building block of empathy to appear during infancy and early childhood. As development progresses, empathic arousal becomes associated with an increasing ability to differentiate between self and other, which is a critical aspect of mature empathetic ability (Decety and Jackson... | 25,261,920 | [
-0.06610328,
0.4597465,
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The sound of sexual commitment breaks the silencing of malaria parasites. | A fundamental binary decision is made by malaria parasites at every asexual cycle in the blood between further proliferation and differentiation into gametocytes, the mosquito transmissible stages. Recent studies on Plasmodium epigenetic regulation, transcriptional control and genetic basis of gametocyte production are... | 25,261,923 | [
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Synthesis of IB-01212 by multiple N-methylations of peptide bonds. | There are many natural peptides with multiple N-methylamino acids that exhibit potent attractive biological activities. N-methylation of a peptide bond(s) is also one of the standard approaches in medicinal chemistry of bioactive peptides, to improve the potency and physicochemical properties, especially membrane perme... | 25,261,926 | [
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Assessment of voice quality after carbon dioxide laser and microdebrider surgery for Reinke edema. | Surgery of Reinke edema requires reduction of the degenerated superficial lamina propria and preservation of the vibratory epithelium. Sixteen patients were included for microdebrider and 10 patients for carbon dioxide (CO2) laser surgery. Vocal analysis was performed before and at 1 and 3 months after surgery. Subject... | 25,261,956 | [
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Low expression of SOCS-1 and SOCS-3 is a poor prognostic indicator for gastric cancer patients. | Inflammation plays an important role in gastric cancer (GC) development and progression. Suppressor of cytokine signaling (SOCS)-1 and SOCS-3 negatively regulate proinflammatory cytokine signaling; however, their prognostic significance in GC remains unknown. We evaluated the clinicopathological correlation and prognos... | 25,261,987 | [
0.2070195,
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Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models. | Haploinsufficiency of the progranulin (PGRN) gene (GRN) causes familial frontotemporal lobar degeneration (FTLD) and modulates an innate immune response in humans and in mouse models. GRN polymorphism may be linked to late-onset Alzheimer's disease (AD). However, the role of PGRN in AD pathogenesis is unknown. Here we ... | 25,261,995 | [
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Effects of β-sitosterol derived from Artemisia capillaris on the activated human hepatic stellate cells and dimethylnitrosamine-induced mouse liver fibrosis. | β-sitosterol is a cholesterol-like phytosterol, which widely distributed in the plant kingdom. Here, anti-fibrotic effect of the β-sitosterol was studied using the activated human hepatic stellate cell (HSC) model and dimethylnitrosamine (DMN)-induced mouse hepatic fibrosis model. HSCs were activated by transforming gr... | 25,262,005 | [
-0.4528088,
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Management of inoperable malignant oesophageal strictures with fully covered WallFlex(®) stent: a multicentre prospective study. | The majority of currently available oesophageal metal stents are partially covered to reduce migration risk. Preliminary experiences with fully covered stents seem to indicate an increased risk of migration in patients treated for malignant dysphagia. The aim of our study was to determine, in this setting, the safety a... | 25,262,010 | [
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Human positive coactivator 4 (PC4) is involved in the progression and prognosis of astrocytoma. | Astrocytoma is the most common primary brain tumor and it is associated with poor prognosis. Accumulating evidences suggest that certain molecular abnormalities or genetic mutations are associated with its progression and prognosis. Human transcriptional coactivator 4 (PC4), originally identified as a transcriptional c... | 25,262,015 | [
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Synthesis of chitosan 3,6-diphenylcarbamate-2-urea derivatives and their applications as chiral stationary phases for high-performance liquid chromatography. | Fourteen chitosan 3,6-diphenylcarbamate-2-urea derivatives were synthesized using well-deacetylated chitosan and the corresponding phenyl isocyanates. After coating them on silica gel, their chiral recognition abilities were evaluated as the chiral stationary phases (CSPs) for high-performance liquid chromatography. Th... | 25,262,030 | [
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Conjugation between quinolone-susceptible bacteria can generate mutations in the quinolone resistance-determining region, inducing quinolone resistance. | Quinolones are an important group of antibacterial agents that can inhibit DNA gyrase and topoisomerase IV activity. DNA gyrase is responsible for maintaining bacteria in a negatively supercoiled state, being composed of subunits A and B. Topoisomerase IV is a homologue of DNA gyrase and consists of two subunits codifi... | 25,262,036 | [
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The use of prognostic factors in inflammatory bowel diseases. | The disease spectrum and natural course of Crohn's disease and ulcerative colitis are highly variable. The majority of Crohn's disease patients will require surgery at a certain stage in their disease compared to only a fraction of the ulcerative colitis patients. Similarly, some patients are destined to experience an ... | 25,262,067 | [
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0.137237,
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0.2342513,
0.06383681,
0.2498052,
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Blood pressure in relation to contamination by polychlorobiphenyls and organochlorine pesticides: Results from a population-based study in the Canary Islands (Spain). | Epidemiological studies have reported significant associations between exposure to persistent organic pollutants (POPs) and increased blood pressure (BP). Environmental exposure to POPs, mainly organochlorine pesticides, is of concern to the population of the Canary Islands, who display a high prevalence of diseases as... | 25,262,074 | [
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0.3499875,
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0.335582,
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Extreme electronic bandgap modification in laser-crystallized silicon optical fibres. | For decades now, silicon has been the workhorse of the microelectronics revolution and a key enabler of the information age. Owing to its excellent optical properties in the near- and mid-infrared, silicon is now promising to have a similar impact on photonics. The ability to incorporate both optical and electronic fun... | 25,262,096 | [
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0.06076139,
0.2750032,
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A feasibility study of full-field optical coherence tomography for rapid evaluation of EUS-guided microbiopsy specimens. | Rapid on-site evaluation of cytologic specimens is a way of determining the adequacy of fine-needle aspiration (FNA). However, alternatives may be useful when the presence of a cytotechnologist and/or pathologist is not possible. To evaluate the feasibility of using full-field optical coherence tomography (FFOCT) for F... | 25,262,102 | [
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0.1116542,
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Epicardial adipose tissue volume as a marker of coronary artery disease severity in patients with diabetes independent of coronary artery calcium: findings from the CTRAD study. | The association between epicardial adipose tissue (EAT) volume and coronary artery disease (CAD) severity was evaluated, independent of traditional risk factors and coronary artery calcium (CAC) scores, in patients with diabetes type 2 (DM-2) using cardiac computed tomography angiography (CTA). A multivariate analysis ... | 25,262,111 | [
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Association between rs2200733 and rs7193343 genetic variants and atrial fibrillation in a Spanish population, and meta-analysis of previous studies. | The objectives of this study were to analyze the association between two genetic variants (rs2200733 and rs7193343) in a Spanish population and the risk of developing atrial fibrillation, and to carry out a systematic review and meta-analysis of these associations. We performed a case-control study involving 257 case p... | 25,262,128 | [
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... |
Spectroscopic (FTIR, FT-Raman, UV and NMR) investigation and NLO, HOMO-LUMO, NBO analysis of 2-Benzylpyridine based on quantum chemical calculations. | In this work, the vibrational characteristics of 2-Benzylpyridine have been investigated. The structure of the molecule has been optimized and the structural characteristics of the molecule have been determined by density functional theory B3LYP method with 6-31G(d,p) basis set. The infrared and Raman spectra have been... | 25,262,142 | [
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Short communication: Conservation of Streptococcus uberis adhesion molecule and the sua gene in strains of Streptococcus uberis isolated from geographically diverse areas. | The objective was to identify and sequence the sua gene (GenBank no. DQ232760; http://www.ncbi.nlm.nih.gov/genbank/) and detect Streptococcus uberis adhesion molecule (SUAM) expression by Western blot using serum from naturally S. uberis-infected cows in strains of S. uberis isolated in milk from cows with mastitis fro... | 25,262,183 | [
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Feeding protein supplements in alfalfa hay-based lactation diets improves nutrient utilization, lactational performance, and feed efficiency of dairy cows. | Due to the increasing cost of soybean meal and concerns of excess N being excreted into the environment, new protein supplements have been developed. Two products that have shown potential in increasing N utilization efficiency are slow-release urea (SRU; Optigen; Alltech Inc., Nicholasville, KY) and ruminal-escape pro... | 25,262,186 | [
0.2616862,
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Intracellular autofluorescence: a biomarker for epithelial cancer stem cells. | Cancer stem cells (CSCs) are thought to drive tumor growth, metastasis and chemoresistance. Although surface markers such as CD133 and CD44 have been successfully used to isolate CSCs, their expression is not exclusively linked to the CSC phenotype and is prone to environmental alteration. We identified cells with an a... | 25,262,208 | [
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0.46248... |
Long-term cost-effectiveness of medical, endoscopic and surgical management of gastroesophageal reflux disease. | The long-term cost effectiveness of medical, endoscopic, and operative treatments for adults with gastroesophageal reflux disease (GERD) remains unclear. We sought to estimate the cost effectiveness of medical, endoscopic, and operative treatments for adults with GERD who require daily proton pump inhibitor (PPI) thera... | 25,262,216 | [
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Canonical and noncanonical roles of Par-1/MARK kinases in cell migration. | The partitioning defective gene 1 (Par-1)/microtubule affinity-regulating kinase (MARK) family of serine-threonine kinases have diverse cellular roles. Primary among these roles are the establishment and maintenance of cell polarity and the promotion of microtubule dynamics. Par-1/MARK kinases also regulate a growing n... | 25,262,242 | [
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0.2797622,
0.04738486,
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Cannabinoid receptor CB1 is involved in nicotine-induced protection against Aβ1-42 neurotoxicity in HT22 cells. | Emerging evidences suggest that nicotine exerts a neuroprotective effect on Alzheimer's disease (AD), yet the precise mechanism is not fully elucidated. Here, HT22 cells were exposed to amyloid beta protein fragment (Aβ)1-42 to mimic the pathological process of neuron in AD. We hypothesized that cannabinoid receptor CB... | 25,262,246 | [
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0.07569085,
0.2869276,
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Prevalence of glucose abnormalities among patients presenting with an acute myocardial infarction. | Patients with an acute myocardial infarction (AMI) who have glucose abnormalities are at increased risk for death and adverse ischemic outcomes. The contemporary prevalence of glucose abnormalities among AMI patients in the United States, as determined by hemoglobin A1c (HbA1c), is unknown. Patients hospitalized with A... | 25,262,255 | [
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... |
Clinical outcomes of hybrid coronary revascularization versus coronary artery bypass surgery in patients with diabetes mellitus. | Hybrid coronary revascularization (HCR) involves minimally invasive left internal mammary artery to left anterior descending coronary artery grafting combined with percutaneous coronary intervention (PCI) of non-left anterior descending vessels. The safety and efficacy of HCR among diabetic patients are unknown. Patien... | 25,262,256 | [
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Safety of coronary angiography and percutaneous coronary intervention via the radial versus femoral route in patients on uninterrupted oral anticoagulation with warfarin. | To evaluate access site and other bleeding complications associated with radial versus femoral access in patients receiving oral anticoagulation (OAC) with warfarin. Patients receiving OAC with warfarin undergoing coronary angiography and percutaneous coronary intervention (PCI) may have OAC continued despite the risk ... | 25,262,264 | [
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... |
Genetic characterization of influenza A virus subtype H7N1 isolated from quail, Thailand. | In Thailand, surveillance for the highly pathogenic avian influenza virus H5N1 (HPAI-H5N1) has revealed high prevalence of the virus in quail in live-bird markets. This study monitored avian influenza viruses (AIVs) in quail farms in an area at high risk for HPAI-H5N1 over a 12-month period from 2009 to 2010. One-step ... | 25,262,289 | [
0.001486827,
-0.310038,
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0.2259053,
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0.1922912,
0.0344614,
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0.07673738,
0.4435824,
0.02111446,
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0.03688477,
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-0.06851282,
0.1481045,
-0.08855256,
-0.3549675,
0.2086316,
0.2243575,
-0.3395292... |
Organic carbon, and major and trace element dynamic and fate in a large river subjected to poorly-regulated urban and industrial pressures (Sebou River, Morocco). | An annual-basis study of the impacts of the anthropogenic inputs from Fez urban area on the water geochemistry of the Sebou and Fez Rivers was conducted mostly focusing on base flow conditions, in addition to the sampling of industrial wastewater characteristic of the various pressures in the studied environment. The m... | 25,262,292 | [
-0.1774881,
0.03155129,
0.2320629,
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0.1255447,
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0.007182408,
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0.2054218,
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0.0474332,
0.1524613,
0.05660413,
0.1359491,
0.08841126,
-0.3683119... |
[Implantation of a program for polymedicated patients within the framework of the Galician Strategy for Integrated Chronic Care]. | A total of 22.8% of citizens in Galicia are older than 65 years and, compared with the Spanish population as a whole, they represent a more elderly population with a higher prevalence of chronic diseases. The SERGAS 2014 strategy and the Galician Strategy for Integrated Chronic Care envision the development of a specif... | 25,262,309 | [
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-0.1894821,
0.1861261,
0.26476... |
[The PROPRESE trial: results of a new health care organizational model in primary care for patients with chronic coronary heart disease based on a multifactorial intervention]. | Comparison of the results from the EUROASPIRE I to the EUROASPIRE III, in patients with coronary heart disease, shows that the prevalence of uncontrolled risk factors remains high. The aim of the study was to evaluate the effectiveness of a new multifactorial intervention in order to improve health care for chronic cor... | 25,262,306 | [
-0.03963553,
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0.3362352,
0.2637302,
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0.25737,
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0.04866679,
0.06055131,
0.2719132,
0.08762407,
0.2236123,
0.2027896,
... |
Personality disorders, alcohol use, and alcohol misuse. | Personality disorders (PDs) are psychiatric conditions that manifest early in life from a mixture of genetics and environment, are highly persistent, and lead to substantial dysfunction for the affected individual and those with whom s/he interacts. In this study we offer new information on the associations between PDs... | 25,262,316 | [
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0.3900247,
0.1514915,
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0.08270307,
0.3683273,
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0.2773937,
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... |
Automating the design of resection guides specific to patient anatomy in knee replacement surgery by enhanced 3D curvature and surface modeling of distal femur shape models. | Personalized resection guides (PRG) have been recently proposed in the domain of knee replacement, demonstrating clinical outcome similar or even superior to both manual and navigated interventions. Among the mandatory pre-surgical steps for PRG prototyping, the measurement of clinical landmarks (CL) on the bony surfac... | 25,262,320 | [
0.07056653,
0.3795582,
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0.0619949,
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0.06142951,
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0.2524331,
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0.4851351,
0.3004767,
-0.2225331,
... |
Computational fluid dynamics in coronary artery disease. | Computational fluid dynamics (CFD) is a widely used method in mechanical engineering to solve complex problems by analysing fluid flow, heat transfer, and associated phenomena by using computer simulations. In recent years, CFD has been increasingly used in biomedical research of coronary artery disease because of its ... | 25,262,321 | [
-0.3404761,
0.167836,
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0.2771852,
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0.02779081,
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0.1598332,
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0.1820235,
-0.1175611,
0.2783342,
0.310991,
0.3531861,
-0.2155737,
0.097... |
Gastrointestinal bleeding as presentation of small bowel metastases of malignant melanoma: Is surgery a good choice? | Melanoma shows a particular predilection in involving small intestine both in a single site and in multiple localization and acute or chronic gastrointestinal bleedings are often the first sign of tumour. We report two cases of GI metastases of malignant melanoma, one presented with only a big mass that cause intestina... | 25,262,323 | [
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0.03418233,
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0.09711105,
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0.1841817,
0.1392063,
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0.1350299,
0.4616641,
-0.1226073,
0.1309461,
0.1021932,
-0.3820732,... |
MWCNT-cysteamine-Nafion modified gold electrode based on myoglobin for determination of hydrogen peroxide and nitrite. | In this work, a novel amperometric biosensor of hydrogen peroxide (H2O2) was developed based on the immobilization of myoglobin (Mb) on the surface of the multi-walled carbon nanotube (MWCNT) -Nafion-cysteamine (CA) modified gold electrode (Au) and its electrocatalytic activity was used for the determination of nitrite... | 25,262,340 | [
-0.5208,
0.1206358,
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0.05650571,
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0.07469709,
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0.2459558,
0.02933323,
0.1862474,
0.08628608,
0.... |
Human PrimPol mutation associated with high myopia has a DNA replication defect. | PrimPol is a primase-polymerase found in humans, and other eukaryotes, involved in bypassing lesions encountered during DNA replication. PrimPol employs both translesion synthesis and repriming mechanisms to facilitate lesion bypass by the replisome. PrimPol has been reported to be a potential susceptibility gene assoc... | 25,262,353 | [
0.01148781,
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0.4098765,
0.2366091,
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0.1700358,
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-0.08902201,
-0.2556594,
0.1518011,
0.2614714,
0.2219993,
-0.00694807... |
Comparative RNA-Seq based dissection of the regulatory networks and environmental stimuli underlying Vibrio parahaemolyticus gene expression during infection. | Vibrio parahaemolyticus is the leading worldwide cause of seafood-associated gastroenteritis, yet little is known regarding its intraintestinal gene expression or physiology. To date, in vivo analyses have focused on identification and characterization of virulence factors--e.g. a crucial Type III secretion system (T3S... | 25,262,354 | [
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0.1507096,
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0.1106141,
0.06661789,
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0.0163508,
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-0.1606356,
0.2643046,
0.5455257,
-0.2199175,... |
NrichD database: sequence databases enriched with computationally designed protein-like sequences aid in remote homology detection. | NrichD (http://proline.biochem.iisc.ernet.in/NRICHD/) is a database of computationally designed protein-like sequences, augmented into natural sequence databases that can perform hops in protein sequence space to assist in the detection of remote relationships. Establishing protein relationships in the absence of struc... | 25,262,355 | [
-0.04813617,
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0.233588,
-0.06625371,
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0.09103999,
0.2367354,
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0.07757612,
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0.1476141,
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-0.2083156,
-0.2152134,
0.0747833,
0.1704336,
-0.11... |
Control of vegetable pests in Benin - Farmers' preferences for eco-friendly nets as an alternative to insecticides. | We investigated if eco-friendly nets (EFNs) are a viable and acceptable alternative to extremely high levels of insecticide use in vegetable production. Using a choice experiment, we found that vegetable producing farmers in Benin preferred all of the characteristics of EFNs except the higher labor requirements. The ne... | 25,262,392 | [
0.0007426953,
0.1278011,
0.02931392,
0.2466097,
0.1034124,
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0.02073111,
-0.01182278,
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0.00706677,
0.02619425,
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-0.5402958,
0.3098038,
-0.02525416,
0.01026488,
-0.170336,
0.5800647,
0.01951374... |
Engineering of Δ9-tetrahydrocannabinol delivery systems based on surface modified-PLGA nanoplatforms. | The objective of this work is to develop a nanoplatform that can potentiate the oral administration of Δ9-tetrahidrocannabinol, a highly lipophilic active agent with very promising antiproliferative and antiemetic activities. To that aim, colloidal carriers based on the biodegradable and biocompatible poly(D,L-lactide-... | 25,262,411 | [
-0.1311492,
-0.0970039,
-0.05304693,
0.1645995,
0.212172,
-0.2176059,
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0.05605726,
0.07427745,
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0.1033844,
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-0.6871436,
-0.08649682,
0.1862459,
0.1931861,
-0.08250526,
0.2379511,
-0.197511... |
Simultaneous determination of 16 phenolic constituents in Spatholobi Caulis by high performance liquid chromatography/electrospray ionization triple quadrupole mass spectrometry. | Spatholobi Caulis, the vine stem of Spatholobus suberectus Dunn, has been widely used in traditional Chinese and folk medicines for treatment of irregular menstruation, blood deficiency and rheumatalgia in clinic. In this study, an accurate and reliable high performance liquid chromatography/electrospray ionization tri... | 25,262,413 | [
0.0164991,
0.3677588,
0.3772089,
-0.123814,
0.312405,
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0.4928204,
0.1780816,
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0.3729016,
0.3255163,
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0.04577244,
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0.16135,
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0.3237027,
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-0.03858387,
-0.3295429,
-0.... |
A process economic assessment of hydrocarbon biofuels production using chemoautotrophic organisms. | Economic analysis of an ARPA-e Electrofuels (http://arpa-e.energy.gov/?q=arpa-e-programs/electrofuels) process is presented, utilizing metabolically engineered Rhodobacter capsulatus or Ralstonia eutropha to produce the C30+ hydrocarbon fuel, botryococcene, from hydrogen, carbon dioxide, and oxygen. The analysis is bas... | 25,262,429 | [
-0.04348058,
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0.05928446,
0.1450074,
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0.0438205,
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0.1211335,
0.1806228,
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0.2008716,
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0.02668776,
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0.2510835,
0.2786882,
0.2726549,
0.1868774,
0.1473524,
-0.09401973,
... |
Autotrophic nitrogen removal process in a potable water treatment biofilter that simultaneously removes Mn and NH4(+)-N. | Ammonia (NH4(+)-N) removal pathways were investigated in a potable water treatment biofilter that simultaneously removes manganese (Mn) and NH4(+)-N. The results indicated a significant loss of nitrogen in the biofilter. Both the completely autotrophic nitrogen removal over nitrite (CANON) process and nitrification wer... | 25,262,432 | [
-0.4032778,
0.4329372,
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0.2479009,
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0.1618088,
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0.0977773,
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0.03842917,
0.2425183,
0.2056438,
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0.2457202,
0.01819589,
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0.2198174,
0.04524345,
0.... |
Influenza A viruses with different amino acid residues at PB2-627 display distinct replication properties in vitro and in vivo: revealing the sequence plasticity of PB2-627 position. | Sequence analyses of influenza PB2 sequences indicate that the 627 position almost exclusively contains either lysine (K) or glutamic acid (E), suggesting a high sequence constraint at this genetic marker. Here, we used a site-directed random mutagenesis method to demonstrate that PB2-627 position has a high sequence p... | 25,262,472 | [
-0.003384453,
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0.1678244,
0.02921901,
0.03465416,
0.1248574,
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0.1408847,
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0.1637566,
0.00510768,
0.0991228,
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0.003384982,
-0.02755368,
0.03968137,
0.113449,
-0.02423918,
-0.220... |
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