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Different interaction modes for protein-disulfide isomerase (PDI) as an efficient regulator and a specific substrate of endoplasmic reticulum oxidoreductin-1α (Ero1α).
Protein-disulfide isomerase (PDI) and sulfhydryl oxidase endoplasmic reticulum oxidoreductin-1α (Ero1α) constitute the pivotal pathway for oxidative protein folding in the mammalian endoplasmic reticulum (ER). Ero1α oxidizes PDI to introduce disulfides into substrates, and PDI can feedback-regulate Ero1α activity. Here...
25,258,311
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The reductive half-reaction of xanthine dehydrogenase from Rhodobacter capsulatus: the role of Glu232 in catalysis.
The kinetic properties of an E232Q variant of the xanthine dehydrogenase from Rhodobacter capsulatus have been examined to ascertain whether Glu(232) in wild-type enzyme is protonated or unprotonated in the course of catalysis at neutral pH. We find that kred, the limiting rate constant for reduction at high [xanthine]...
25,258,317
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Hippocampal volume and white matter disease in the prediction of dementia in Parkinson's disease.
Longitudinal neuroimaging studies could provide insights into pathophysiology of cognitive impairment in PD. We examined the role of hippocampal atrophy and cerebral white matter disease as risk factors for mild cognitive impairment and dementia in PD. Prospective longitudinal study of patients with mild PD in a tertia...
25,258,331
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Pd(II) complexes of [44]- and [46]decaphyrins: the largest Hückel aromatic and antiaromatic, and Möbius aromatic macrocycles.
Reductive metalation of [44]decaphyrin with [Pd2(dba)3] provided a Hückel aromatic [46]decaphyrin Pd(II) complex, which was readily oxidized upon treatment with DDQ to produce a Hückel antiaromatic [44]decaphyrin Pd(II) complex. In CH2Cl2 solution the latter complex underwent slow tautomerization to a Möbius aromatic [...
25,258,332
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Fast BDNF serum level increase and diurnal BDNF oscillations are associated with therapeutic response after partial sleep deprivation.
Preclinical and clinical studies support a role for brain-derived neurotrophic factor (BDNF) in the pathophysiology of stress-related mood disorders. Furthermore, BDNF seems to be linked to antidepressant action. Available pharmacological treatments for depression are characterized by significant limitations with low e...
25,258,340
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How I treat Burkitt lymphoma in adults.
Burkitt lymphoma (BL) is an aggressive B-cell non-Hodgkin lymphoma that is almost uniformly associated with translocations involving the gene for MYC on chromosome 8. The 3 subtypes of BL, endemic, sporadic, and immunodeficiency-associated, differ from epidemiologic and clinical perspectives but may be genetically simi...
25,258,344
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Enlargement of visual processing regions in social anxiety disorder is related to symptom severity.
Social anxiety disorder (SAD) is associated with altered brain function and structure, but most structural studies include small samples and findings are mixed. This study compared regional gray matter volume between 48 SAD patients and 29 healthy controls (HC) as well as the relationship between volume and symptom sev...
25,258,347
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Change in consumption patterns for treatment-seeking patients with alcohol use disorder post-bariatric surgery.
The aim of this study is to describe the clinical phenotype of alcohol use disorder (AUD) treatment-seeking patients with Roux-en-Y Gastric Bypass Surgery (RYGB) history; and to compare it to AUD obese non-RYGB controls. Retrospective study of electronic medical records for all patients 30-60years treated at the Mayo C...
25,258,356
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Diagnostic yield of emergency department arch-to-vertex CT angiography in patients with suspected acute stroke.
Our aim was to investigate how often relevant diagnostic findings in an arch-to-vertex CTA scan, obtained specifically as part of the acute stroke CT protocol, are located in the head, neck, and upper chest regions. Radiology reports were reviewed in 302 consecutive patients (170 men, 132 women; median ages, 66 and 73 ...
25,258,370
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Heritable variation of mRNA decay rates in yeast.
Gene expression levels are determined by the balance between rates of mRNA transcription and decay, and genetic variation in either of these processes can result in heritable differences in transcript abundance. Although the genetics of gene expression has been a subject of intense interest, the contribution of heritab...
25,258,386
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Characterization of duodenal expression and localization of fatty acid-sensing receptors in humans: relationships with body mass index.
Fatty acids (FAs) stimulate the secretion of gastrointestinal hormones, including cholecystokinin (CCK) and glucagon like peptide-1 (GLP-1), which suppress energy intake. In obesity, gastrointestinal responses to FAs are attenuated. Recent studies have identified a key role for the FA-sensing receptors cluster of diffe...
25,258,406
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Myosin 5b loss of function leads to defects in polarized signaling: implication for microvillus inclusion disease pathogenesis and treatment.
Microvillus inclusion disease (MVID) is an autosomal recessive condition resulting in intractable secretory diarrhea in newborns due to loss-of-function mutations in myosin Vb (Myo5b). Previous work suggested that the apical recycling endosomal (ARE) compartment is the primary location for phosphoinositide-dependent pr...
25,258,405
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Fetal echocardiography for congenital heart disease diagnosis: a meta-analysis, power analysis and missing data analysis.
Prenatal ultrasonography is the most widely available diagnostic test for fetal congenital heart disease (CHD), but the factors influencing its diagnostic accuracy remain uncertain despite extensive research. The aim of the present study was to evaluate the potential role of demographic, clinical and ultrasonographic c...
25,258,423
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Super-Refractory Status Epilepticus: Report of a Case and Review of the Literature.
Super-refractory status epilepticus (SE; ie, SE continuing or recurring despite 24 hours of general anesthesia) is a severe condition with high percentage of mortality and morbidity. Usually, this condition occurs because of serious brain damage; nevertheless, some patients develop super-refractory SE without identifia...
25,258,428
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An active learning complementary and alternative medicine session in a self-care therapeutics class.
To provide an interactive, non-supplement based complementary and alternative medicine (CAM) session in a self-care therapeutics class and to evaluate the effect of the session on pharmacy students' perceptions and knowledge of CAM. Second professional year pharmacy students enrolled in a required 3-credit course title...
25,258,446
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The fact of ignorance: revisiting the Socratic method as a tool for teaching critical thinking.
Critical thinking, while highly valued as an ability of health care providers, remains a skill that many educators find difficult to teach. This review provides an analysis examining why current methods of teaching critical thinking to health care students (primarily medical and pharmacy students) often fail and descri...
25,258,449
[ -0.1180748, -0.3003321, -0.08182477, -0.01592661, 0.2215714, 0.1491789, 0.006312317, -0.1225279, 0.0231203, -0.03276367, 0.118737, 0.3365601, -0.1244641, 0.05005391, -0.6827016, 0.07586162, -0.576977, 0.2102382, -0.4453377, 0.3620602, 0.1349533, 0.1937751, 0.228837, -0....
Cryopreservation of Ovarian Tissue: Detailed Description of Methods for Transport, Freezing and Thawing.
<bPurpose:</b In many cases cancer therapy leads to an irreversible reduction or even loss of ovarian reserve. Cryopreservation of ovarian tissue with subsequent thawing and re-transplantation of tissue after the cancer is in remission constitutes a promising method to preserve fertility in women. To date, more than 25...
25,258,453
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Primary Malignant Vaginal Melanoma - Case Report and Review of the Literature.
With fewer than 250 cases published worldwide, primary vaginal melanoma is an extremely rare malignant entity which is mostly diagnosed in advanced stages. The estimated incidence of vaginal melanoma is 0.026/100 000 women per year. The poor prognosis for advanced tumour stages and different therapies used in very limi...
25,258,467
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The time-course of feature interference in agreement comprehension: Multiple mechanisms and asymmetrical attraction.
Attraction interference in language comprehension and production may be as a result of common or different processes. In the present paper, we investigate attraction interference during language comprehension, focusing on the contexts in which interference arises and the time-course of these effects. Using evidence fro...
25,258,471
[ -0.1309172, 0.1962097, -0.1513781, 0.07219305, 0.4661665, -0.310196, -0.3235488, -0.2750722, 0.1412034, 0.1733727, -0.2959866, -0.08391389, -0.1154656, -0.31469, -0.3133432, -0.264584, -0.06486376, 0.2120777, -0.02629831, -0.04865367, 0.433448, 0.2292248, -0.05293205, -...
Integrated microscopy techniques for comprehensive pathology evaluation of an implantable left atrial pressure sensor.
The safety and efficacy of an implantable left atrial pressure (LAP) monitoring system is being evaluated in a clinical trial setting. Because the number of available specimens from the clinical trial for histopathology analysis is limited, it is beneficial to maximize the usage of each available specimen by relying on...
25,258,469
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Long-term functional results and isokinetic strength evaluation after arthroscopic tenotomy of the long head of biceps tendon.
The objective of this study is to evaluate the biomechanical function of the upper arm after arthroscopic long head of biceps (LHB) tenotomy at long-term follow-up. Twenty-five male subjects ranging from 30 to 63 years old were evaluated at a mean follow-up of 7.0 years after tenotomy. Bilateral isokinetic testing was ...
25,258,498
[ -0.1372498, 0.135093, -0.3240977, -0.2833066, -0.09791201, -0.4159824, -0.3195721, 0.1419069, -0.1289522, 0.01899479, 0.1522944, -0.3011945, -0.2208222, -0.2449902, 0.08961927, -0.4195925, 0.1373845, -0.01807763, -0.6418199, 0.05368432, 0.1783045, 0.1550001, 0.1416483, ...
Goal-directed decision making in prefrontal cortex: A computational framework.
Research in animal learning and behavioral neuroscience has distinguished between two forms of action control: a habit-based form, which relies on stored actio n values, and a goal-dir ected form, which forecasts and compares action outcomes based on a model of the environment. While habit-based control has been the su...
25,258,502
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Maintaining persistence and adherence with subcutaneous growth-hormone therapy in children: comparing jet-delivery and needle-based devices.
Persistence and adherence with subcutaneous growth hormone (GH; somatropin) therapy in children is widely acknowledged to be suboptimal. This study aimed to investigate how the use of a jet-delivery device, ZomaJet(®), impacts on medication-taking behaviors compared to needle-based devices. A retrospective cohort study...
25,258,519
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Improved absorption and in vivo kinetic characteristics of nanoemulsions containing evodiamine-phospholipid nanocomplex.
The purpose of this study was to assess the improved absorption and in vivo kinetic characteristics of a novel water-in-oil nanoemulsion containing evodiamine-phospholipid nanocomplex (NEEPN) when administered orally. NEEPN was fabricated by loading an evodiamine-phospholipid nanocomplex into a water-in-oil nanoemulsiv...
25,258,531
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Sleep and cognitive problems in patients with attention-deficit hyperactivity disorder.
Attention-deficit hyperactivity disorder (ADHD) is characterized by inattentive and impulsive behavior. Many ADHD patients reportedly have cognitive dysfunction and sleep problems, including longer sleep latency, lower sleep efficiency, and shorter total sleep time. The purpose of this study was to examine neurocogniti...
25,258,537
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Amyotrophic lateral sclerosis - cell based therapy and novel therapeutic development.
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease, characterized by the predominant loss of motor neurons (MNs) in primary motor cortex, the brainstem, and the spinal cord, causing premature death in most cases. Minimal delay of pathological development by available medicine has prompted the search for...
25,258,567
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Comparison between Flail Arm Syndrome and Upper Limb Onset Amyotrophic Lateral Sclerosis: Clinical Features and Electromyographic Findings.
Flail arm syndrome (FAS), an atypical presentation of amyotrophic lateral sclerosis (ALS), is characterized by progressive, predominantly proximal, weakness of upper limbs, without involvement of the lower limb, bulbar, or respiratory muscles. When encountering a patient who presents with this symptomatic profile, poss...
25,258,573
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Standards in breast surgery - Breast Units - future and necessity.
Breast cancer is the most common type of malignant neoplasm affecting women. In Poland there are nearly 15 500 new cases of the disease and over 5200 deaths due to it observed annually. As it was necessary to provide those suffering from breast cancer with combined highly specialist treatment, it was required that sepa...
25,258,578
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The clinical usefulness of assessing the concentration of cell adhesion molecules sVCAM-1 and sICAM-1 in the serum of women with primary breast cancer.
Assessment of the concentrations of the soluble forms of the cell adhesion molecules sVCAM-1 and sICAM-1 in serum of female breast cancer patients. These concentrations were assessed in relation to factors such as: age, clinical stage of disease, histological grade of malignancy, the status of the local axillary lymph ...
25,258,583
[ -0.1134684, -0.1079126, -0.02153733, -0.7259721, -0.2475832, -0.2377254, -0.062437, 0.2773483, -0.2078418, 0.3180516, 0.0107741, 0.02478272, -0.2440416, -0.2224128, 0.114123, -0.4017808, -0.2581173, 0.00282509, 0.2908609, 0.2255218, 0.3167699, 0.1085244, -0.3159611, 0.3...
Temperature dependence of sensitized Er(3+) luminescence in silicon-rich oxynitride films.
The temperature dependence of sensitized Er(3+) emission via localized states and silicon nanoclusters has been studied to get an insight into the excitation and de-excitation processes in silicon-rich oxynitride films. The thermal quenching of Er(3+) luminescence is elucidated by terms of decay time and effective exci...
25,258,608
[ 0.02378294, 0.01527605, 0.1528131, 0.2954957, -0.1333162, -0.1584771, -0.2175879, -0.3405589, 0.1683845, 0.1930327, -0.1202984, -0.09775877, 0.02442029, -0.01142111, -0.8148697, -0.3261966, -0.5328694, 0.08187827, -0.06959103, -0.02184397, 0.2559307, 0.2738144, -0.1171695...
Factors associated with utilization of dipeptidyl-4 inhibitors in patients with type 2 diabetes mellitus: a cross-sectional retrospective study.
Dipeptidyl-4 (DPP-4) inhibitors are oral antidiabetic agents recently introduced to Malaysia. Thus, limited data is available on their utilization patterns and factors associated with their use. This study aims to analyse the utilization patterns of DPP-4 inhibitors, factors that influenced the choice of agent, and the...
25,258,626
[ 0.1091041, 0.0227501, -0.2943938, -0.03204162, 0.09855949, -0.2529966, -0.07948535, 0.09462775, 0.1564351, -0.2917879, -0.01478219, -0.04500703, 0.03542837, -0.3347328, -0.1696985, 0.1380943, -0.1796461, 0.214696, -0.0241906, -0.02813602, 0.04908628, 0.1200206, -0.252544,...
Estimation of Measurement Uncertainties for the DGT Passive Sampler Used for Determination of Copper in Water.
Diffusion-based passive samplers are increasingly used for water quality monitoring. While the overall method robustness and reproducibility for passive samplers in water are widely reported, there has been a lack of a detailed description of uncertainty sources. In this paper an uncertainty budget for the determinatio...
25,258,629
[ -0.05189057, 0.1062577, 0.1532931, 0.0002643209, 0.233342, -0.3112045, -0.05871876, 0.1370035, 0.00724419, 0.08306261, -0.03830044, 0.2606909, 0.1914076, 0.2662552, -0.3144211, -0.09078711, -0.2076376, 0.3021062, -0.3908953, 0.09805469, 0.2680423, -0.1285419, -0.1916448, ...
Sanitary conditions of food vending sites and food handling practices of street food vendors in Benin City, Nigeria: implication for food hygiene and safety.
To determine the sanitary conditions of vending sites as well as food handling practices of street food vendors in Benin City, Nigeria. A descriptive cross-sectional study was done using an observational checklist and researcher-administered questionnaire. 286 randomly selected vending units were surveyed, and their op...
25,258,630
[ 0.01269812, 0.1519722, 0.05779186, -0.2579451, 0.006542286, -0.2277215, -0.005404411, -0.2056066, -0.3396261, -0.09330831, 0.3332554, -0.2057182, -0.07286827, -0.1650546, -0.4406494, -0.005309905, -0.5370256, -0.07105569, 0.3155453, -0.05973259, -0.5035424, 0.277307, 0.09...
Antenatal care strengthening in Jimma, Ethiopia: a mixed-method needs assessment.
We assessed how health system priorities matched user expectations and what the needs for antenatal care (ANC) strengthening were for improved maternal health in Jimma, Ethiopia. A questionnaire survey among all recent mothers in the study area was conducted to study the content of ANC and to identify the predictors of...
25,258,631
[ 0.2174222, 0.01199412, 0.1106925, -0.2172771, 0.1584661, -0.126215, -0.01573136, 0.04047788, 0.08873393, 0.03816416, 0.07442195, -0.1023552, -0.0786319, 0.1153551, -0.1188316, 0.09524477, -0.4401411, 0.05837115, -0.5640621, -0.1464488, 0.4183071, -0.2097547, 0.1062398, ...
Study of antioxidant activity of sheep visceral protein hydrolysate: Optimization using response surface methodology.
The main objective of this experiment was optimal use of none edible protein source to increase nutritional value of production with high biological function, including antioxidant activity. Sheep visceral (stomach and intestine) was used as substrate. Response surface methodology (RSM) was used to optimize hydrolysis ...
25,258,632
[ 0.07165954, -0.3124518, -0.1512164, 0.1182015, 0.3735119, 0.1645833, -0.1233088, 0.1318169, 0.09017577, -0.2773253, 0.1542901, -0.3472812, 0.2202702, -0.257852, 0.02608846, 0.1731333, -0.5957035, 0.03036461, 0.2098893, 0.3652331, -0.04877692, 0.2507493, -0.3970201, 0.03...
Normal range of bleeding time in urban and rural areas of Borujerd, west of Iran.
Bleeding time (BT) is the oldest and simplest test for assessing the platelets (Plts) function. BT can affect by several factors such as race and diet, which has a wide reference range. The aim of this project is to determine the normal range of BT in Borujerd, Iran. Determining the normal range of BT can help us to mo...
25,258,635
[ 0.09053911, 0.1827986, 0.20528, 0.2648911, 0.150151, -0.2053309, 0.3285516, 0.3730536, 0.2994788, -0.1414105, 0.1947472, 0.4041565, -0.1293976, 0.0647924, -0.4132751, -0.2676622, -0.174518, 0.2782703, -0.1431616, 0.08367753, -0.3256534, 0.189644, 0.05286155, -0.06380647...
Preferential effect of akt2-dependent signaling on the cellular viability of ovarian cancer cells in response to EGF.
Overexpression of the epidermal growth factor receptor (EGFR) is associated with the malignant phenotype in many cancers including ovarian cancer, which leads to increased cell proliferation and survival. In spite of emerging EGFR inhibitors as a potentially useful agent, they are largely ineffective in patients with a...
25,258,648
[ 0.2124455, 0.008328064, 0.02096434, -0.4158794, 0.1061749, 0.04507579, 0.07258216, 0.03347425, -0.1349981, 0.1766627, 0.1161654, -0.04752914, -0.5555619, 0.03400214, 0.05765029, -0.3769265, -0.166277, 0.458336, 0.04174603, 0.01439181, 0.233714, 0.3925985, -0.04071055, 0...
Photothermal Treatment of Human Pancreatic Cancer Using PEGylated Multi-Walled Carbon Nanotubes Induces Apoptosis by Triggering Mitochondrial Membrane Depolarization Mechanism.
Pancreatic cancer (PC) is one of the most lethal solid tumor in humans, with an overall 5-year survival rate of less than 5%. Thermally active carbon nanotubes have already brought to light promising results in PC research and treatment. We report here the construct of a nano-biosystem based on multi-walled carbon nano...
25,258,649
[ -0.01154261, -0.389914, 0.02639977, 0.2329857, -0.0804367, 0.0755958, -0.08300842, 0.1880479, 0.2286481, 0.02918045, -0.04102397, -0.1060106, -0.2404649, -0.2748647, -0.1426534, -0.2023576, -0.3339804, 0.3874956, -0.2025533, 0.3146114, 0.3531044, 0.2285994, -0.2122353, ...
Patterns of Opacification in Coronary CT Angiography: Contrast Differences and Gradients.
Iodinated contrast delivery is a key component of coronary CT angiography. However, the purpose of contrast delivery has been limited to morphology alone. Specifically, iodine opacification of the coronary lumen has been used to separate it from the coronary artery wall and lesions within the coronary arteries. Because...
25,258,657
[ -0.345471, 0.5198169, -0.3291784, -0.1565422, -0.1372985, -0.1282029, -0.3409467, -0.1873379, 0.1296069, 0.1616594, -0.07198073, -0.01765612, -0.1609816, -0.03366876, -0.09334084, -0.3682389, -0.4373671, 0.02217812, 0.08430583, -0.05918447, 0.01752208, 0.1111362, -0.24317...
Ovarian cancer stem cells: Can targeted therapy lead to improved progression-free survival?
Despite significant effort and research funds, epithelial ovarian cancer remains a very deadly disease. There are no effective screening methods that discover early stage disease; the majority of patients are diagnosed with advanced disease. Treatment modalities consist primarily of radical debulking surgery followed b...
25,258,665
[ 0.06420055, -0.2098719, 0.05188968, -0.4245466, 0.005482976, -0.2085204, 0.05760129, 0.1761919, 0.1120095, 0.253935, 0.08394165, 0.1964309, -0.2213971, 0.06245163, -0.2316407, -0.184024, -0.3762549, 0.04065465, 0.241026, 0.004092061, 0.1311062, 0.1845595, -0.1948343, 0....
Boost IORT in Breast Cancer: Body of Evidence.
The term IORT (intraoperative radiotherapy) is currently used for various techniques that show decisive differences in dose delivery. The largest evidence for boost IORT preceding whole breast irradiation (WBI) originates from intraoperative electron treatments with single doses around 10 Gy, providing outstandingly lo...
25,258,684
[ 0.02519044, -0.07549733, -0.1539372, -0.3902425, -0.2041671, -0.522679, 0.1921977, 0.02153653, -0.03181775, -0.07382984, -0.02710982, -0.2230974, -0.03090994, -0.4932837, -0.3991373, -0.02940622, -0.1411774, 0.02496932, -0.04875509, -0.1979504, 0.1945293, 0.3390201, -0.12...
Papillary fibroelastoma of the right ventricular free wall.
Papillary fibroelastoma is a rare benign cardiac tumor that usually arises from the valvular endocardium and its development in the cardiac chambers is extremely rare. A 52-year-old woman complained of palpitations and echocardiography revealed a cardiac tumor. Resection was performed via the right ventricle and main p...
25,258,692
[ -0.3957916, 0.1487552, -0.434314, -0.3377189, -0.2238004, -0.2705666, 0.04247792, -0.03286136, 0.0375234, 0.1483746, 0.3255691, 0.5680276, -0.2981862, -0.2041761, 0.1363333, -0.05309305, -0.3983505, 0.1708165, 0.03581203, -0.1530523, 0.2543505, 0.1078822, -0.2852914, 0....
Surgical reconstruction of the urinary sphincter after traumatic longitudinal disruption.
The question is whether the urethral sphincter may be reconstructed after longitudinal injury similar to anal sphincter injuries. Analogue to obstetric, anal sphincter repair, an approximation repair of the sphincter may be feasible. An overlap repair is possible in anal sphincter repair, but because of the little tiss...
25,258,694
[ -0.0887957, 0.007203138, -0.1129374, -0.06635348, 0.09960563, -0.2779534, -0.1966223, -0.03804189, 0.2620735, 0.2507857, 0.1510311, -0.2209647, 0.09032258, -0.1535137, -0.3613371, 0.06831045, -0.347479, -0.05443283, -0.4494283, -0.2206091, 0.2896132, -0.113241, 0.1135792,...
Uncertainty analysis of knowledge reductions in rough sets.
Uncertainty analysis is a vital issue in intelligent information processing, especially in the age of big data. Rough set theory has attracted much attention to this field since it was proposed. Relative reduction is an important problem of rough set theory. Different relative reductions have been investigated for pres...
25,258,725
[ -0.0404463, 0.1396892, 0.1018962, 0.2770003, 0.1977865, -0.106931, 0.2422832, 0.01937934, 0.3215966, -0.02571208, 0.08716869, 0.1678884, 0.06039011, 0.3414321, -0.5095516, 0.1327675, -0.2358601, 0.1358623, -0.08038652, 0.05896265, 0.2058597, 0.1156719, -0.1740195, 0.117...
On power idealization filter topologies of lattice implication algebras.
The aim of this paper is to introduce power idealization filter topologies with respect to filter topologies and power ideals of lattice implication algebras, and to investigate some properties of power idealization filter topological spaces and their quotient spaces.
25,258,735
[ -0.003904036, 0.2573991, 0.01065178, 0.2684585, -0.001496946, -0.1451275, -0.3418052, -0.271855, 0.2654004, -0.1542905, -0.1915191, -0.4406512, -0.0716348, 0.1285894, -0.436604, -0.1233854, -0.3832832, -0.1004323, -0.3269745, -0.03140137, 0.2139896, -0.131424, -0.2361645,...
Fast SAR image change detection using Bayesian approach based difference image and modified statistical region merging.
A novel fast SAR image change detection method is presented in this paper. Based on a Bayesian approach, the prior information that speckles follow the Nakagami distribution is incorporated into the difference image (DI) generation process. The new DI performs much better than the familiar log ratio (LR) DI as well as ...
25,258,740
[ -0.1858963, 0.08928925, 0.154771, 0.01246513, -0.2337992, -0.2702181, -0.1761468, 0.4106892, 0.3594793, -0.09996943, -0.01816706, 0.05945866, -0.07881199, 0.4061215, -0.2910683, -0.1286838, -0.4162812, -0.0831547, 0.1678043, -0.04811854, 0.2389187, 0.2753071, -0.138082, ...
The crosslink enhanced emission (CEE) in non-conjugated polymer dots: from the photoluminescence mechanism to the cellular uptake mechanism and internalization.
The crosslink enhanced emission (CEE) in a new type of non-conjugated polymer dots (PDs) is proved. The enhanced PL originates from the decreased vibration and rotation of amino-based chromophores. Furthermore, the cellular uptake mechanism and internalization of PDs were investigated in detail.
25,259,373
[ -0.3816457, 0.03537522, 0.1472389, 0.08346704, 0.0495748, -0.1110783, -0.1832927, 0.08127793, 0.2529497, 0.3196366, -0.2639593, 0.2205673, -0.1340836, 0.1354066, -0.1098816, -0.1009302, -1.048049, 0.02721409, -0.1876972, 0.08084073, -0.0004642128, 0.1562307, -0.06698269, ...
Conducting nanofibers and organogels derived from the self-assembly of tetrathiafulvalene-appended dipeptides.
We demonstrate the nonaqueous self-assembly of a low-molecular-mass organic gelator based on an electroactive p-type tetrathiafulvalene (TTF)-dipeptide bioconjugate. We show that a TTF moiety appended with diphenylalanine amide derivative (TTF-FF-NH2) self-assembles into one-dimensional nanofibers that further lead to ...
25,259,412
[ -0.1494111, -0.0572481, 0.002434538, -0.02857507, 0.07407367, -0.2026322, -0.2461768, 0.05352229, -0.02286073, 0.1724604, 0.05448624, 0.1409309, 0.08555209, -0.2535923, -0.2766629, -0.1336552, -0.5970381, 0.2388372, -0.2095052, 0.2515889, 0.05683573, -0.005932927, -0.2212...
Synthesis of aminocarbonyl N-acylhydrazones by a three-component reaction of isocyanides, hydrazonoyl chlorides, and carboxylic acids.
A novel one-pot multicomponent synthesis of α-aminocarbonyl N-acylhydrazones starting from readily available hydrazonoyl chlorides, isocyanides, and carboxylic acids is reported. The strategy exploits the ability of the carboxylic acid as a third component to suppress all competing reactions between nitrile imines and ...
25,259,417
[ -0.3976476, 0.2629935, -0.07301173, 0.04502443, 0.181915, 0.1030826, -0.6837132, 0.1111337, 0.2517465, 0.142887, -0.1637778, 0.03404873, 0.1667444, 0.00991159, -0.1753359, -0.1627772, -0.6105574, 0.1033767, -0.09841023, -0.004405096, 0.215965, -0.07347799, -0.04904581, ...
Antibacterial mode of action of 1,8-dihydroxy-anthraquinone from Porphyra haitanensis against Staphylococcus aureus.
As one kind of anthraquinone dihydroxy derivatives, 1,8-dihydroxy-anthraquinone (Dan) with strong antibacterial activity against Staphylococcus aureus was first isolated from Porphyra haitanensis. Here, we report on the investigation of the antibacterial mode of action of Dan on the Gram-positive bacterium S. aureus. T...
25,259,418
[ -0.2162991, -0.1725577, -0.06485342, 0.3613474, 0.1133168, 0.07735679, -0.2154672, 0.07171957, 0.3025288, -0.1093793, 0.07161975, 0.1088097, -0.4141351, -0.1783979, -0.4088625, -0.02750421, -0.2141448, 0.4916219, -0.1276525, 0.107708, 0.6390484, 0.07525488, -0.3234116, ...
[Genetic variants in miRNAs and its association with breast cancer].
In Mexico, breast cancer represents the first cause of cancer death in females. At the molecular level, non-coding RNAs and especially microRNAs have played an important role in the origin and development of this neoplasm In the Anglo-Saxon population, diverse genetic variants in microRNA genes and in their targets are...
25,259,427
[ -0.2802241, -0.2998512, 0.3475606, -0.2936655, -0.1897262, -0.05905575, -0.2050459, -0.009863901, 0.05229167, -0.05317945, 0.08674879, 0.2347802, -0.1684798, -0.5573961, -0.5222282, -0.3063974, -0.1978532, -0.05978312, 0.3125981, 0.08982057, 0.279103, 0.1387978, -0.238721...
A general and practical palladium-catalyzed monoarylation of β-methyl C(sp³)-H of alanine.
A palladium-catalyzed monoarylation of β-methyl C(sp(3))-H of an alanine derivative with aryl iodides using an 8-aminoquinoline auxiliary is described. The reaction is highly efficient, scalable and compatible with a variety of functional groups with complete retention of chirality, providing a general and practical ac...
25,259,442
[ -0.4074374, 0.06723319, -0.08716665, 0.01105717, -0.07533554, -0.06162881, -0.49138, 0.1030679, 0.1713865, 0.1127494, -0.05379457, -0.109739, 0.2036554, 0.378464, -0.1762194, -0.3503058, -0.4964396, 0.05395836, -0.2254353, 0.3484037, 0.08893428, 0.01391178, -0.04436431, ...
Influence of wave and current flow on sediment-carrying capacity and sediment flux at the water-sediment interface.
In nearshore waters, spatial and temporal scales of waves, tidal currents, and circulation patterns vary greatly. It is, therefore, difficult to combine these factors' effects when trying to predict sediment transport processes. This paper proposes the concept of significant wave velocity, which combines the effects of...
25,259,499
[ -0.02933775, 0.3355071, 0.1533561, -0.1119003, 0.1317445, -0.2125301, -0.001288337, -0.04813122, -0.004789132, 0.2007638, -0.3742201, -0.3403369, -0.217263, 0.4291524, -0.09941589, -0.2898203, -0.3480221, 0.0330311, 0.002809707, -0.08913425, 0.2778015, -0.1237129, -0.0618...
Trehalose improves human fibroblast deficits in a new CHIP-mutation related ataxia.
In this work we investigate the role of CHIP in a new CHIP-mutation related ataxia and the therapeutic potential of trehalose. The patient's fibroblasts with a new form of hereditary ataxia, related to STUB1 gene (CHIP) mutations, and three age and sex-matched controls were treated with epoxomicin and trehalose. The ef...
25,259,530
[ -0.1356412, 0.09965447, -0.0122192, 0.005775052, -0.1730277, -0.1151803, 0.1912364, 0.005891955, -0.07261366, 0.208679, 0.1789717, 0.1188827, -0.250146, -0.4485774, 0.000241659, -0.1425687, -0.5211995, -0.08838812, -0.1262643, 0.2272809, 0.1163063, 0.1340784, -0.5722842, ...
Exploiting the therapeutic potential of leptin signaling in cachexia.
The anorexia-cachexia syndrome is a complication of many chronic conditions including cancer, chronic obstructive pulmonary disease, congestive heart failure, and chronic kidney disease (CKD). Leptin levels are significantly elevated in CKD patients and are associated with markers of poor nutritional status as well as ...
25,259,544
[ 0.1161763, -0.2140486, -0.05272244, -0.3762611, 0.09994151, 0.05028163, 0.1661749, 0.1680764, -0.155507, 0.02617095, -0.1228728, 0.2062036, -0.0744401, 0.06318066, -0.2457155, -0.2863478, -0.1361437, 0.222264, 0.1324547, 0.01758486, -0.1803315, 0.299693, -0.1979741, -0....
Intrathecal morphine analgesia after cervical and thoracic spinal cord tumor surgery.
The aim of this study was to provide evidence for the effect of intrathecal morphine application after spinal cord tumor resection. Twenty patients participated in a prospective open proof-of-concept study. During dural closure, morphine (7 μg/kg) was injected into the subarachnoid space. All patients were monitored in...
25,259,556
[ 0.06927207, 0.2269836, -0.4275845, -0.2769091, -0.1341102, -0.2745729, -0.07252108, -0.08770828, -0.0006991957, 0.02347866, -0.13685, -0.2476856, 0.1680247, -0.2325989, -0.2388811, -0.2967718, -0.3136009, 0.278279, 0.1973477, 0.01729654, 0.1631408, 0.2246137, 0.102635, ...
Differences in cellular immune competence explain parasitoid resistance for two coleopteran species.
The immune defence of an organism is evolving continuously, causing counteradaptations in interacting species, which in turn affect other ecological and evolutionary processes. Until recently comparative studies of species interactions and immunity, combining information from both ecological and immunological fields, h...
25,259,576
[ 0.2716542, -0.02758086, -0.01809162, -0.2223183, 0.1766446, -0.2976238, -0.4485935, -0.008103229, 0.1263105, 0.0144216, 0.03880728, -0.191196, -0.09601846, -0.2971216, -0.1592338, -0.2367948, -0.4354243, 0.07505385, 0.3088331, 0.3489011, 0.2806626, -0.1349146, -0.170635, ...
Multivariate dimensionality reduction approaches to identify gene-gene and gene-environment interactions underlying multiple complex traits.
The elusive but ubiquitous multifactor interactions represent a stumbling block that urgently needs to be removed in searching for determinants involved in human complex diseases. The dimensionality reduction approaches are a promising tool for this task. Many complex diseases exhibit composite syndromes required to be...
25,259,584
[ 0.2111841, -0.0846194, -0.1597852, 0.1583628, -0.07500624, -0.332542, -0.08706518, -0.01824416, -0.05388727, -0.1115223, 0.1821536, 0.03274193, 0.02557094, 0.2896792, -0.3365525, 0.2266297, 0.02649309, 0.03554323, -0.2051437, 0.1414088, -0.225942, 0.2031117, 0.08781794, ...
A feasibility study of an intravascular imaging antenna to image atherosclerotic plaques in Swine using 3.0 T MRI.
To investigate the feasibility of an intravascular imaging antenna to image abdominal aorta atherosclerotic plaque in swine using 3.0T magnetic resonance imaging (MRI). Atherosclerotic model was established in 6 swine. After 8 months, swine underwent an MR examination, which was performed using an intravascular imaging...
25,259,585
[ -0.04488524, 0.5652978, -0.04336112, 0.1686537, 0.06974552, -0.218538, 0.1485493, 0.139287, 0.1564391, 0.06282886, -0.1193848, -0.1782338, 0.2982258, -0.3309888, -0.4715131, -0.2550649, -0.8149728, 0.4336807, -0.2465354, -0.01906648, 0.09192206, -0.06039388, -0.2090795, ...
Neuromuscular adaptations to different modes of combined strength and endurance training.
The present study investigated neuromuscular adaptations between same-session combined strength and endurance training with 2 loading orders and different day combined training over 24 weeks. 56 subjects were divided into different day (DD) combined strength and endurance training (4-6 d·wk(-1)) and same-session combin...
25,259,588
[ -0.2001428, 0.1947251, -0.04735411, -0.3093501, -0.1471437, -0.5820031, 0.05501143, -0.3718642, -0.1916201, 0.1345766, -0.1042782, -0.01973568, 0.0001838756, -0.2913385, -0.5886385, -0.342784, -0.6801834, 0.2361918, -0.2305117, 0.1421855, -0.0626294, -0.1714221, 0.0215141...
Individualisation of time-motion analysis: a method comparison and case report series.
This study compared the intensity distribution of time-motion analysis data, when speed zones were categorized by different methods. 12 U18 players undertook a routine battery of laboratory- and field-based assessments to determine their running speed corresponding to the respiratory compensation threshold (RCT), maxim...
25,259,591
[ -0.2551958, 0.0671677, -0.07056171, 0.3073803, 0.06814015, -0.2921792, -0.2662687, -0.1913153, -0.1418245, -0.3272561, -0.06216687, 0.02197864, -0.1790561, -0.0714476, -0.5258812, -0.5105699, 0.001223269, 0.03178094, -0.3030115, 0.1067879, -0.1264836, 0.003372866, -0.0766...
The preoperative incidence of raised intracranial pressure in nonsyndromic sagittal craniosynostosis is underestimated in the literature.
The presence of raised intracranial pressure (ICP) in untreated nonsyndromic, isolated sagittal craniosynostosis (SC) is an important functional indication for surgery. A retrospective review was performed of all 284 patients presenting with SC to the Oxford Craniofacial Unit between 1995 and 2010. Intraparenchymal ICP...
25,259,602
[ -0.173072, -0.2581886, 0.08721244, -0.5048525, -0.07840449, -0.2559036, -0.319572, -0.409506, 0.129447, 0.002283563, 0.2074937, -0.1740955, -0.2289853, -0.3624338, -0.198124, 0.136424, -0.5460546, 0.2432065, 0.05284392, 0.02139152, -0.1775326, -0.1609531, 0.1440296, -0....
Effects of an 8-weeks erythropoietin treatment on mitochondrial and whole body fat oxidation capacity during exercise in healthy males.
The present investigation was performed to elucidate if the non-erythropoietic ergogenic effect of a recombinant erythropoietin treatment results in an impact on skeletal muscle mitochondrial and whole body fatty acid oxidation capacity during exercise, myoglobin concentration and angiogenesis. Recombinant erythropoiet...
25,259,652
[ -0.2400897, 0.3524852, -0.1641443, 0.1359251, 0.2468933, -0.2565025, 0.1159196, -0.1056536, -0.3946141, -0.2317719, -0.06760801, 0.242164, -0.09008183, -0.06410405, -0.3193636, 0.03775728, -0.1803108, 0.1544596, -0.2354236, 0.3420731, -0.1214625, 0.369879, 0.1077291, -0...
Plant vigor metrics determine spatio-temporal distribution dynamics of Oulema melanopus (Coleoptera: Chrysomelidae) and its larval parasitoid, Tetrastichus julis (Hymenoptera: Eulophidae).
The cereal leaf beetle, Oulema melanopus (L.) (Coleoptera: Chrysomelidae), is a new invasive insect pest of oat, wheat, and barley in western Canada. Biological control with its principal larval parasitoid, Tetrastichus julis Walker (Hymenoptera: Eulophidae), is the primary management strategy. However, to implement co...
25,259,693
[ 0.1173834, 0.1596702, 0.07508392, -0.1605577, 0.07045184, -0.3629581, -0.02513622, 0.07647546, -0.3145376, -0.01911207, -0.01243729, -0.08453594, -0.1815391, -0.2165783, -0.6450791, 0.2257057, -0.2594012, 0.2478226, 0.3041526, -0.2447641, 0.2140392, 0.5506109, -0.2252306,...
Host plant mediates foraging behavior and mutual interference among adult Stethorus gilvifrons (Coleoptera: Coccinellidae) preying on Tetranychus urticae (Acari: Tetranychidae).
Physical plant characteristics can influence predator foraging and their behavioral responses to each other. This study examined the searching efficiency and functional response of adult female Stethorus gilvifrons Mulsant foraging for Tetranychus urticae Koch (Acari: Tetranychidae) on castor bean, common bean, and cuc...
25,259,694
[ 0.4552456, 0.06486567, 0.2060485, -0.0162444, 0.6794919, 0.02713433, -0.07376395, 0.03035858, 0.1589729, -0.1516869, -0.09406108, 0.119967, -0.1735787, 0.06521202, -0.1362248, 0.2372684, -0.445955, 0.1414336, -0.245305, 0.03644468, -0.04079107, 0.1639612, -0.1093728, 0....
Is impaired kidney function an independent predictor of the risk of myocardial infarction in HIV-infected individuals?
We examined whether impaired kidney function is an independent risk factor for myocardial infarction in HIV-infected individuals without pre-existing coronary artery disease. The odds ratio for impaired kidney function fell from 1.22 (95% confidence interval 0.90-1.66) to 0.99 (95% confidence interval 0.69-1.41) after ...
25,259,706
[ -0.02522334, 0.04081991, -0.4549834, -0.04872943, 0.08954375, -0.1375486, -0.03548661, 0.3360873, -0.1076286, -0.04710161, 0.03904765, 0.008161517, 0.107243, 0.09697173, -0.5283601, -0.1909719, -0.1562875, -0.01220074, -0.09227712, 0.4148411, 0.07917301, 0.2180738, -0.033...
Van der Waals interactions in the self-assembly of 5-amino[6]helicene on Cu(100) and Au(111).
A combination of Scanning Tunnelling Microscopy and Density Functional Theory simulations highlights the role of van der Waals interactions in the self-assembly of an aminohelicene on Cu(100) and Au(111).
25,259,722
[ -0.2289927, -0.05951213, -0.09146751, -0.1123871, 0.3232044, 0.1207263, -0.4093908, -0.2171811, 0.2442217, 0.1064269, -0.0793433, 0.02121582, -0.006799204, -0.2216033, -0.4665756, -0.1227973, -0.3877535, 0.2510304, -0.3289628, 0.0439611, 0.2324018, 0.1134192, -0.005484729...
Investigating population structure of Sea Lamprey (Petromyzon marinus, L.) in Western Iberian Peninsula using morphological characters and heart fatty acid signature analyses.
This study hypothesizes the existence of three groups of sea lamprey Petromyzon marinus L. in Portugal (North/Central group, Tagus group, and Guadiana group), possibly promoted by seabed topography isolation during the oceanic phase of the life cycle. Within this context, our purpose was to analyze the existence of a s...
25,259,723
[ 0.008738891, 0.04911244, 0.03514269, -0.2060548, 0.1404239, -0.2823114, -0.2367283, 0.1160101, 0.1240213, -0.226758, -0.0932513, -0.4303964, 0.05197019, -0.1957962, -0.0689029, -0.171675, -0.1152271, 0.268077, 0.05607231, 0.5342448, 0.1958483, 0.5733031, -0.2659177, 0.0...
Encapsulating non-human primate multipotent stromal cells in alginate via high voltage for cell-based therapies and cryopreservation.
Alginate cell-based therapy requires further development focused on clinical application. To assess engraftment, risk of mutations and therapeutic benefit studies should be performed in an appropriate non-human primate model, such as the common marmoset (Callithrix jacchus). In this work we encapsulated amnion derived ...
25,259,731
[ -0.1932267, -0.1569866, -0.2840953, 0.2145694, 0.1033505, -0.09266941, -0.2702799, 0.3806213, 0.4518125, 0.04828259, -0.1512474, -0.1239688, -0.2311652, -0.06965163, -0.3356277, -0.3241098, 0.1386176, -0.06534676, -0.2831764, 0.00271791, 0.3567941, 0.1982181, 0.07059801, ...
Experiences of stigma and discrimination among caregivers of persons with schizophrenia in China: a field survey.
In China, caregivers for family members with schizophrenia play an important role in treatment and recovery but may experience stigma and discrimination simply because of their family relationship. The object of this study was to measure the degrees and correlates of stigma and discrimination experiences among this gro...
25,259,732
[ 0.03892243, 0.5352312, 0.1242358, 0.01126747, -0.08783045, -0.1389378, -0.2333578, -0.01835224, 0.05161708, 0.04841833, 0.190525, 0.1285871, -0.3594512, 0.210777, 0.4780219, 0.009428754, -0.3040628, 0.05983852, -0.2376905, 0.1950105, -0.23332, 0.2035856, 0.0117258, -0.2...
Disproportional decrease in office blood pressure compared with 24-hour ambulatory blood pressure with antihypertensive treatment: dependency on pretreatment blood pressure levels.
The long-term relationship between 24-hour ambulatory blood pressure (ABP) and office BP in patients on therapy is not well documented. From a registry we included all patients in whom antihypertensive therapy needed to be uptitrated. Drug treatment included the direct renin inhibitor aliskiren or an angiotensin-conver...
25,259,741
[ -0.0283615, 0.02495434, -0.4444781, -0.158358, 0.1738855, -0.1453997, 0.05784067, 0.1063237, 0.2283834, -0.3693606, -0.05256956, 0.163823, 0.2072785, 0.1764337, -0.5745026, -0.07293254, -0.1694458, 0.4203415, 0.1178487, 0.1619318, 0.02922262, 0.196681, -0.2984559, 0.015...
Treatment-resistant hypertension and the incidence of cardiovascular disease and end-stage renal disease: results from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).
Apparent treatment-resistant hypertension (aTRH) is defined as uncontrolled hypertension despite the use of ≥3 antihypertensive medication classes or controlled hypertension while treated with ≥4 antihypertensive medication classes. Although a high prevalence of aTRH has been reported, few data are available on its ass...
25,259,745
[ -0.01336831, 0.1463068, -0.09144461, -0.1638536, 0.1190384, -0.2573087, 0.02186668, 0.2966534, 0.1863846, -0.1985222, 0.001392208, 0.09423833, 0.1245951, 0.03465848, -0.2701004, -0.124382, -0.4499859, 0.3282433, -0.05145777, 0.238357, -0.2696449, 0.1943789, -0.2145547, ...
Male lineage strata of Brazilian population disclosed by the simultaneous analysis of STRs and SNPs.
Brazil has a large territory divided in five geographical regions harboring highly diverse populations that resulted from different degrees and modes of admixture between Native Americans, Europeans and Africans. In this study, a sample of 605 unrelated males was genotyped for 17 Y-STRs and 46 Y-SNPs aiming a deep char...
25,259,770
[ -0.1165371, 0.2089033, 0.3110924, 0.2288824, -0.2083986, -0.5547305, -0.004496695, -0.0622414, 0.1623807, 0.06806225, 0.02356599, -0.1759207, -0.01867249, -0.06102955, -0.4130216, -0.3602225, -0.02381524, -0.04797918, 0.3124808, 0.01535145, 0.1965919, 0.1274934, -0.116723...
Carbohydrate modified diet &amp; insulin sensitizers reduce body weight &amp; modulate metabolic syndrome measures in EMPOWIR (enhance the metabolic profile of women with insulin resistance): a randomized trial of normoglycemic women with midlife weight gain.
Progressive midlife weight gain is associated with multiple adverse health outcomes and may represent an early manifestation of insulin resistance in a distinct subset of women. Emerging data implicate hyperinsulinema as a proximate cause of weight gain and support strategies that attenuate insulin secretion. To assess...
25,259,787
[ -0.06104795, 0.1553257, 0.07051293, -0.2519253, -0.06288888, -0.1976387, -0.1540622, 0.1857611, 0.4193919, 0.01983471, -0.03147419, 0.06974114, -0.03198004, -0.1637255, -0.3359617, -0.3128254, -0.4525846, 0.2023194, 0.1127483, -0.0769828, -0.2555299, 0.1306181, -0.0294152...
Simulation modelling of population dynamics of mosquito vectors for rift valley Fever virus in a disease epidemic setting.
Rift Valley Fever (RVF) is weather dependent arboviral infection of livestock and humans. Population dynamics of mosquito vectors is associated with disease epidemics. In our study, we use daily temperature and rainfall as model inputs to simulate dynamics of mosquito vectors population in relation to disease epidemics...
25,259,792
[ -0.08242956, 0.08953808, -0.2017774, -0.0765692, -0.04874976, -0.4557946, 0.2873985, 0.1718751, -0.01529056, 0.02446705, 0.1935351, 0.4109686, 0.02320953, 0.4010967, -0.4037464, -0.147773, -0.2935672, 0.04074702, 0.06015303, -0.02326556, 0.09782518, -0.1233733, -0.3392443...
Selective expression of myosin IC Isoform A in mouse and human cell lines and mouse prostate cancer tissues.
Myosin IC is a single headed member of the myosin superfamily. We recently identified a novel isoform and showed that the MYOIC gene in mammalian cells encodes three isoforms (isoforms A, B, and C). Furthermore, we demonstrated that myosin IC isoform A but not isoform B exhibits a tissue specific expression pattern. In...
25,259,793
[ -0.2604544, -0.219417, -0.2722559, -0.1370289, 0.08691588, 0.09216807, -0.1666547, 0.361766, 0.1984117, 0.1198628, 0.1980392, 0.2731413, 0.03702455, -0.2202044, -0.7123418, 0.06919073, -0.07274285, 0.06089038, 0.1725099, -0.1873453, 0.1392717, 0.1217649, 0.09327414, 0.2...
Dispositional optimism and coping strategies in patients with a kidney transplant.
&amp;nbsp;Dispositional optimism is a personal resource that determines the coping style and adaptive response to chronic diseases. The aim of this study was to assess the correlations between dispositional optimism and coping strategies in patients with recent kidney transplantation and evaluate the differences in the...
25,259,815
[ -0.02699815, -0.1535916, -0.1998427, 0.2080373, 0.1567753, -0.3813962, -0.2072967, -0.174558, -0.08745193, 0.06013817, 0.3266374, -0.05017445, -0.3355066, 0.1043334, -0.2101631, -0.378145, -0.3383841, 0.06057594, -0.3546062, 0.2921458, -0.407595, 0.3077873, 0.179134, -0...
Assessment of subclinical acute kidney injury after abdominal aortic aneurysm surgery using novel markers: L-FABP and H-FABP.
One of the most severe complications of repair surgery for abdominal aortic aneurysms (AAA) is acute kidney injury (AKI). Even small rises in serum creatinine are associated with increased mortality. The aim of this study was to assess the dynamics of AKI after elective AAA surgery using novel markers. The study group ...
25,259,818
[ -0.03979841, -0.1859018, -0.6149373, -0.350837, 0.3705879, -0.3992579, -0.160932, 0.4579474, -0.01181563, 0.1649447, 0.07354596, 0.01625073, 0.1645506, -0.2338782, -0.1511837, -0.1774014, -0.3231904, -0.002530871, 0.04211531, 0.0459283, -0.02853746, 0.3632008, -0.2697778,...
Magnetic anisotropy and mechanism of magnetic relaxation in Er(III) single-ion magnets.
Magnetic anisotropy is a key component in the design of single-molecule magnets (SMMs) possessing a large barrier height for magnetization reversal. Lanthanide-based SMMs are the most promising candidates in this arena as they offer a large magnetic anisotropy due to the presence of strong spin-orbit coupling. Among la...
25,259,840
[ -0.04651326, 0.03945918, 0.2461244, 0.04557336, 0.1347779, -0.136378, -0.1945472, -0.420371, 0.1898204, 0.0948321, -0.3083139, 0.05572112, -0.05309296, -0.07408714, -0.6421672, -0.2115965, -0.6020117, 0.053131, -0.1929404, 0.02658579, 0.11428, -0.04073963, -0.134893, 0....
Diagnostic efficacy of cell block immunohistochemistry, smear cytology, and liquid-based cytology in endoscopic ultrasound-guided fine-needle aspiration of pancreatic lesions: a single-institution experience.
The diagnostic efficiency of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) cytology varies widely depending on the treatment method of the specimens. The present study aimed to evaluate the diagnostic efficacy of cell block (CB) immunohistochemistry, smear cytology (SC), and liquid-based cytology (LBC) ...
25,259,861
[ 0.5299693, -0.1235158, -0.1098566, -0.4581734, -0.2040908, -0.02706183, -0.07285924, -0.0617108, 0.288492, 0.02800923, 0.05025668, 0.2593951, -0.2337572, -0.004831464, 0.2118143, -0.5184453, -0.2937527, 0.2696235, 0.2086365, 0.1224496, 0.2344185, 0.2995823, -0.09573682, ...
A disposable evanescent wave fiber optic sensor coated with a molecularly imprinted polymer as a selective fluorescence probe.
We have developed a disposable evanescent wave fiber optic sensor by coating a molecularly imprinted polymer (MIP) containing a fluorescent signaling group on a 4-cm long polystyrene optical waveguide. The MIP is composed of a naphthalimide-based fluorescent monomer, which shows fluorescence enhancement upon binding wi...
25,259,879
[ -0.2332375, 0.1200042, -0.03388015, -0.02956976, 0.05878622, -0.1092308, -0.3877331, 0.1916339, 0.3984672, 0.02495127, 0.08900364, -0.1403932, 0.2616811, -0.2431873, -0.4675034, -0.04218984, -0.8274986, 0.3438847, -0.03236163, -0.1377787, 0.04840116, 0.0007457724, -0.0522...
The RAG recombinase dictates functional heterogeneity and cellular fitness in natural killer cells.
The emergence of recombination-activating genes (RAGs) in jawed vertebrates endowed adaptive immune cells with the ability to assemble a diverse set of antigen receptor genes. In contrast, innate lymphocytes, such as natural killer (NK) cells, are not believed to require RAGs. Here, we report that NK cells unable to ex...
25,259,923
[ -0.03805556, -0.252161, -0.2944141, -0.1839287, 0.1707642, -0.2106631, -0.1339108, 0.08973474, 0.2002888, 0.1993007, 0.1247987, 0.04938131, -0.2221984, -0.09742568, -0.3898958, -0.3192538, -0.3971406, -0.120838, 0.214914, 0.33269, 0.1139781, 0.1502147, -0.1836551, -0.23...
RNA-RNA interactions enable specific targeting of noncoding RNAs to nascent Pre-mRNAs and chromatin sites.
Intermolecular RNA-RNA interactions are used by many noncoding RNAs (ncRNAs) to achieve their diverse functions. To identify these contacts, we developed a method based on RNA antisense purification to systematically map RNA-RNA interactions (RAP-RNA) and applied it to investigate two ncRNAs implicated in RNA processin...
25,259,926
[ 0.009684744, 0.05125448, 0.0939685, -0.1416135, -0.002904808, 0.1027068, -0.2119202, 0.4035601, 0.3729638, 0.1496492, -0.03915631, -0.1563735, 0.1687654, -0.1440621, -0.1274583, -0.03373333, -0.2601856, 0.03476723, 0.2186136, -0.230836, 0.4142654, 0.02736554, -0.1359851, ...
Toward conceptualization, discriminant validation, and coherent nomenclature for inter-disciplinary theoretical transfer.
Beyond calling attention to Lee, Cho, Seo, Lee, and Choi's (2014) worthy construct validation regimen, the purpose of this brief note is to extend the study's effect by interpreting the broader than usual empirical and theoretical connections in a way that may not be obvious.
25,259,936
[ -0.06149578, -0.1071503, -0.07611043, -0.03511678, 0.1393254, -0.3104178, -0.1181683, 0.2842918, 0.1308402, -0.2524301, -0.0946393, -0.2728411, 0.1203611, -0.03983403, -0.4100465, -0.04413024, -0.1293601, 0.2006226, -0.1212521, 0.06203299, -0.2167033, -0.05551171, 0.07621...
Does current evidence support the use of intraoperative cell salvage in reducing the need for blood transfusion in caesarean section?
An important cause of maternal morbidity and direct maternal death is obstetric haemorrhage at caesarean section. Concerns regarding allogeneic blood safety, limited blood supplies and rising health costs have collectively generated enthusiasm for the utility of methods intended to reduce the use of allogeneic blood tr...
25,259,949
[ -0.04907677, -0.03984384, -0.1120713, -0.1288268, -0.0494841, -0.1795407, -0.04340949, -0.3130808, 0.1272163, -0.07949912, -0.1965905, 0.3947609, -0.3274638, 0.09232808, 0.07464571, -0.3738837, -0.01556307, 0.04828876, 0.002338499, -0.1667904, 0.03436885, 0.4422886, -0.00...
Near infra-red characterization of changes in flavan-3-ol derivatives in cocoa (Theobroma cacao L.) as a function of fermentation temperature.
Flavan-3-ols were successfully extracted from cocoa by the Fast-Prep device and analyzed by HPLC-DAD, and their identifications were confirmed by injection of authentic standards. (-)-Epicatechin was the most abundant component with an average of 9.4 mg/g dried cocoa powder. More than 700 cocoa samples were used to cal...
25,259,956
[ 0.1039131, 0.3783223, -0.1796914, 0.4728904, 0.02398057, -0.1717668, -0.06319794, 0.4436228, 0.2676371, -0.1727631, 0.1702716, 0.2486551, 0.04627226, -0.4215049, -0.8518198, -0.1853832, -0.5081796, 0.2498358, 0.1667138, 0.1893568, 0.1852626, 0.4242776, -0.2782807, 0.086...
ER - the key to the highway.
The endoplasmic reticulum (ER) is the key organelle at the start of the secretory pathway and the list of its functions is continually growing. The ER organization as a tubular/cisternal network at the cortex of plant cells has recently been shown to be governed by the membrane tubulation proteins of the reticulon fami...
25,259,957
[ 0.06714077, 0.1750499, 0.1084026, 0.1265367, 0.1550634, -0.2509611, -0.1819672, 0.09614307, 0.02999171, 0.1903203, 0.02825591, -0.4161918, 0.006937686, 0.2158749, -0.3498216, -0.02750426, -0.1876723, 0.1391605, 0.2525424, -0.3170132, 0.1329709, 0.4244884, -0.04908805, -...
Rare Red Rashes: A Case Report of Levetiracetam-Induced Cutaneous Reaction and Review of the Literature.
Cutaneous reactions secondary to medications are rare but can be serious events resulting in morbidity and mortality and can be caused by anticonvulsant medications. Levetiracetam has been considered relatively safe compared with other antiepileptics with regard to skin eruptions. We report a case of a cutaneous reacti...
25,259,954
[ -0.1786579, -0.2192248, 0.003344224, -0.2673011, 0.4227466, -0.1698258, -0.04102178, -0.3580768, 0.002852038, -0.02751991, -0.09790447, 0.212112, 0.01988185, 0.142258, -0.1020309, 0.0004590231, -0.09140349, 0.1852362, -0.03296803, 0.1043666, 0.19946, 0.3039792, -0.1199, ...
Organic Cation Transporter-Mediated Clearance of Cardiovascular Drugs: A Pharmacological Perspective.
There exist a number of mechanisms to clear xenobiotics from human circulation. For cationic drugs, clearance is performed by human organic cation transporters 1 and 2 (hOCT1 and hOCT2), which are expressed in the liver and kidney, respectively. Given the prevalence of patients taking cardiovascular drugs, the present ...
25,259,955
[ -0.1166362, 0.0227049, -0.09974366, -0.04872426, 0.0492313, -0.2929194, -0.1896406, 0.298916, -0.05003685, -0.02237481, 0.1248736, 0.1732589, 0.3089695, 0.4704217, -0.5274156, -0.2388846, -0.5523478, 0.1505708, 0.23362, 0.1062561, -0.07031921, 0.3157735, -0.2506003, 0.0...
Maximally natural supersymmetry.
We consider 4D weak scale theories arising from 5D supersymmetric (SUSY) theories with maximal Scherk-Schwarz breaking at a Kaluza-Klein scale of several TeV. Many of the problems of conventional SUSY are avoided. Apart from 3rd family sfermions the SUSY spectrum is heavy, with only ∼50% tuning at a gluino mass of ∼2  ...
25,259,967
[ 0.3051473, -0.02962257, -0.0747046, 0.06366324, 0.1771268, -0.1388256, -0.2993137, -0.2729517, 0.2955825, 0.1174709, 0.04606813, -0.222103, -0.1708824, 0.1355063, -0.3848777, -0.128503, -0.4499351, -0.1032031, 0.1152514, -0.1086479, 0.3796724, 0.1681196, -0.09885813, 0....
K(L) - K(S) mass difference from lattice QCD.
We report on the first complete calculation of the K_{L}-K_{S} mass difference, ΔM_{K}, using lattice QCD. The calculation is performed on a 2+1 flavor, domain wall fermion ensemble with a 330 MeV pion mass and a 575 MeV kaon mass. We use a quenched charm quark with a 949 MeV mass to implement Glashow-Iliopoulos-Maiani...
25,259,970
[ -0.1196317, -0.05152198, -0.07770191, 0.0409287, 0.356764, -0.1350715, -0.2040226, 0.1209201, 0.2062358, -0.3181386, 0.007549584, 0.1411713, 0.08303232, 0.1901725, -0.5382292, 0.02100049, -0.5529367, 0.226732, 0.09954729, 0.04419492, 0.3174164, -0.0653986, -0.1494096, 0...
Intermittency in integrable turbulence.
We examine the statistical properties of nonlinear random waves that are ruled by the one-dimensional defocusing and integrable nonlinear Schrödinger equation. Using fast detection techniques in an optical fiber experiment, we observe that the probability density function of light fluctuations is characterized by tails...
25,259,980
[ 0.0004913365, 0.0884122, -0.08921725, 0.1764778, 0.05315034, -0.5760972, -0.2942685, -0.06558422, 0.2599482, -0.2531958, 0.1048927, -0.2713387, -0.03428562, 0.2908899, -0.2057387, -0.0204239, -0.6805341, 0.09572107, 0.01863616, -0.120085, 0.09868029, 0.1174069, -0.0563773...
Multimode one-way waveguides of large Chern numbers.
Current experimental realizations of the quantum anomalous Hall phase in both electronic and photonic systems have been limited to a Chern number of one. In photonics, this corresponds to a single-mode one-way edge waveguide. Here, we predict quantum anomalous Hall phases in photonic crystals with large Chern numbers o...
25,259,982
[ -0.002135424, 0.02290054, -0.09138321, -0.1170518, 0.2057239, -0.2375995, -0.5807593, -0.1046387, 0.2037674, -0.05056235, -0.1572443, 0.01618899, 0.1108749, 0.2156268, -0.5315771, -0.07365761, -0.5390778, 0.07638853, 0.01271861, -0.2352395, 0.1184145, 0.01739631, -0.08004...
Gapless topological Fulde-Ferrell superfluidity in spin-orbit coupled Fermi gases.
Topological superfluids usually refer to a superfluid state which is gapped in the bulk but metallic at the boundary. Here we report that a gapless, topologically nontrivial superfluid with an inhomogeneous Fulde-Ferrell pairing order parameter can emerge in a two-dimensional spin-orbit coupled Fermi gas, in the presen...
25,259,986
[ -0.02671988, 0.07392291, 0.004201494, 0.0244844, 0.3591467, -0.07777766, -0.5536531, -0.2333534, -0.07662016, -0.2036176, -0.202742, -0.02354557, 0.1171523, 0.2847302, -0.510946, -0.09032103, -0.5554339, -0.1886403, -0.04579347, -0.1708039, -0.0668688, -0.07302349, -0.124...
Silicon-carbon bond inversions driven by 60-keV electrons in graphene.
We demonstrate that 60-keV electron irradiation drives the diffusion of threefold-coordinated Si dopants in graphene by one lattice site at a time. First principles simulations reveal that each step is caused by an electron impact on a C atom next to the dopant. Although the atomic motion happens below our experimental...
25,259,987
[ -0.1880638, 0.107732, -0.1174771, 0.02824087, 0.2862682, -0.112086, -0.2650911, -0.1503945, 0.2857967, 0.06714928, -0.1691796, -0.08152617, -0.03205372, 0.02363706, -0.6990715, -0.01049853, -0.3218277, 0.1642091, -0.05848647, 0.1198383, 0.1079119, 0.1296667, -0.1386817, ...
High chemical activity of a perovskite surface: reaction of CO with Sr(3)Ru(2)O(7).
Adsorption of CO at the Sr(3)Ru(2)O(7)(001) surface was studied with low-temperature scanning tunneling microscopy (STM) and density functional theory. In situ cleaved single crystals terminate in an almost perfect SrO surface. At 78 K, CO first populates impurities and then adsorbs above the apical surface O with a bi...
25,259,988
[ 0.08491373, -0.04444421, -0.1546079, -0.04341172, 0.265032, -0.07894962, -0.1986473, -0.09078022, -0.1271368, 0.1852094, -0.1404867, 0.1251582, -0.01332832, 0.05836874, -0.8461159, -0.08574347, -0.09003196, 0.2676127, 0.2221698, 0.1433361, 0.3129546, 0.2870952, -0.1427609...
Comparison of a condensed 12-week version and a 24-week version of a family-based pediatric weight management program.
The current study compares the effectiveness of a condensed 12-week version and a 24-week version of the same pediatric behavioral weight management program. Children (n=162) between the ages of 8 and 18 years (baseline BMIz=2.39; standard deviation=0.29) were randomized to either a 12- or 24-week version of the same b...
25,260,025
[ -0.3333322, 0.5818877, -0.370824, -0.02124244, 0.2357882, -0.3603129, -0.3909764, -0.09094352, 0.2775434, -0.08307065, 0.08689468, 0.2879391, -0.1132266, -0.454362, -0.6146035, 0.03368194, -0.02449198, -0.1944873, -0.2208301, 0.1351592, -0.1198309, 0.06890538, -0.2887147,...
Are combined same-day treatments the future for photorejuvenation? Review of the literature on combined treatments with lasers, intense pulsed light, radiofrequency, botulinum toxin, and fillers for rejuvenation.
Skin rejuvenation requires a treatment combination including lasers, intense pulsed light (IPL), radiofrequency, botulinum toxin (BT) and fillers. A combined approach is considered optimum but usually same-day combined treatments are avoid and lasers are performed prior to filler or toxin injections owing to the concer...
25,260,050
[ -0.07139394, -0.003460743, -0.2391754, -0.0387203, 0.1857066, -0.4254237, 0.04342892, 0.001538413, 0.1557308, -0.05214251, 0.06338673, 0.229235, 0.02513751, -0.6141759, -0.2588452, 0.03269836, 0.08246692, -0.1124218, 0.2895561, -0.108314, 0.1084231, 0.1106161, -0.16535, ...
Improvement in skin wrinkles using a preparation containing human growth factors and hyaluronic acid serum.
Skin aging is accompanied by wrinkle formation. At some sites, such as the periorbital skin, this is a relatively early phenomenon. We evaluated the anti-wrinkle effect of a preparation containing human growth factor and hyaluronic acid serum on periorbital wrinkles (crow's feet). In total, 23 Korean women (age range: ...
25,260,051
[ 0.2100821, -0.2027208, -0.299204, -0.003492039, 0.4534774, -0.06954233, -0.1539043, -0.1121758, 0.3694035, -0.1295316, -0.01258859, 0.08573802, -0.1369888, -0.1349014, 0.03022714, 0.01227971, 0.04721821, 0.2108683, 0.2112106, -0.1250827, -0.06299605, 0.2859129, -0.4459415...
Controlled release study on microencapsulated mixture of fipronil and chlorpyrifos for the management of white grubs (Holotrichia parallela) in peanuts (Arachis hypogaea L.).
This study was conducted to determine the release dynamics of a microencapsulated mixture of fipronil and chlorpyrifos in peanut fields and its efficacy against white grubs. The results indicated that microencapsulation significantly stabilized this mixture against degradation in the environment so that a single dose o...
25,260,064
[ 0.04833924, -0.145215, 0.2645113, -0.2850312, 0.1669188, -0.2514231, -0.2814562, 0.2006838, 0.06480259, -0.009307355, 0.05817996, 0.2855809, -0.1435829, 0.2535651, -0.1273285, 0.05710901, -0.2456456, -0.06911748, -0.03748796, 0.03370281, -0.0750791, 0.3271185, -0.09236921...