title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Educational Differences in Adolescents' Sexual Health: A Pervasive Phenomenon in a National Dutch Sample. | Educational level is strongly associated with age of first intercourse and risk of unintended pregnancies. This study examined these associations in a large representative sample of Dutch adolescents and also included associations of educational level with other sexual health aspects. Adolescents aged 12 to 25 (3,926 b... | 25,260,077 | [
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Ideal bipolar host materials with bis-benzimidazole unit for highly efficient solution-processed green electrophosphorescent devices. | An ideal host material with high triplet energy, suitable HOMO energy level, excellent thermal and electrochemical stability, and bipolar charge carrier transport ability was synthesized. A high external quantum efficiency of 13.7% and a luminance efficiency of 48.2 cd A(-1) with low efficiency roll-off were achieved i... | 25,260,110 | [
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Complex behavior: from cannibalism to suicide in the vitamin B1 biosynthesis world. | Although thiamin was the first vitamin discovered over a century ago, it is only within the last decade that its metabolism has begun to be unraveled. Over the last few years, several structural and biochemical studies have provided insight into the unprecedented mechanisms of the proteins involved, revealing some rema... | 25,260,119 | [
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Donor- and/or acceptor-substituted expanded radialenes: theory, synthesis, and properties. | The synthesis of donor- (D) and/or acceptor (A)-expanded [4]radialenes has been developed on the basis of readily available dibromoolefin (7), tetraethynylethene (10 and 20), and vinyl triflate (12) building blocks. The successful formation of D/A radialenes relies especially on (1) effective use of a series alkynyl pr... | 25,260,123 | [
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Molecular insight into the effect of lipid bilayer environments on thrombospondin-1 and calreticulin interactions. | Thrombospondin-1 (TSP1) binding to cell surface calreticulin (CRT) stimulates the association of CRT with low-density lipoprotein (LDL) receptor-related protein (LRP1) to signal focal adhesion disassembly and engagement of cellular activities. A recent study demonstrated that membrane rafts are necessary for TSP1-media... | 25,260,145 | [
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Sodium thiosulfate attenuates acute lung injury in mice. | Acute lung injury is characterized by neutrophilic inflammation and increased lung permeability. Thiosulfate is a stable metabolite of hydrogen sulfide, a gaseous mediator that exerts antiinflammatory effects. Although sodium thiosulfate (STS) has been used as an antidote, the effect of STS on acute lung injury is unkn... | 25,260,144 | [
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A calix[2]triazole[2]arene-based fluorescent chemosensor for probing the copper trafficking pathway in Wilson's disease. | A pyrenyl-appended calix[2]triazole[2]arene displaying excellent selectivity for Cu(2+) over other metal ions in pyrenyl excimer emission changes was synthesized. The binding mode with Cu(2+) was supported through nuclear magnetic resonance (NMR) studies and density functional theory (DFT) calculations. Fluorescence im... | 25,260,151 | [
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The expression of NPPA splice variants during mouse cardiac development. | Natriuretic peptide precursor-A (NPPA) is an early and specific marker for functional myocardium of the embryonic heart. NPPA gene encodes for a precursor of atrial natriuretic peptide (ANP). So far, three alternatively spliced variants have been reported for NPPA in human. In mouse, no alternatively spliced transcript... | 25,260,157 | [
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Health risk for children and adults consuming apples with pesticide residue. | The presence of pesticide residues in apples raises serious health concerns, especially when the fresh fruits are consumed by children, particularly vulnerable to the pesticide hazards. This study demonstrates the results from nine years of investigation (2005-2013) of 696 samples of Polish apples for 182 pesticides us... | 25,260,164 | [
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Randomized controlled trial of parental responsiveness intervention for toddlers at high risk for autism. | This study tested the effects of a parent-mediated intervention on parental responsiveness with their toddlers at high risk for an autism spectrum disorder (ASD). Participants included caregivers and their 66 toddlers at high risk for ASD. Caregivers were randomized to 12 sessions of an individualized parent education ... | 25,260,191 | [
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Magnetically-assisted surface enhanced raman spectroscopy (MA-SERS) for label-free determination of human immunoglobulin G (IgG) in blood using Fe3O4@Ag nanocomposite. | Development of methods allowing determination of even ultralow levels of immunoglobulins in various clinical samples including whole human blood and plasma is a particular scientific challenge, especially due to many essential discoveries in the fields of immunology and medicine in the past few decades. The determinati... | 25,260,194 | [
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Polymicrogyria, Large Corpus Callosum and Psychomotor Retardation in Four-Year-Old Girl: Potential Association Based on MR Findings. A Case Report and Literature Review. | SUMMARY - We describe a child from consanguineous parents presenting mega corpus callosum (MegaCC), polymicrogyria, psychomotor retardation with swallowing difficulties and language impairment perhaps linked to the syndrome of megalencephaly-polymicrogyria-mega corpus callosum (MEG-PMG-MegaCC). Reviewing the literature... | 25,260,206 | [
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The factor structure of the Pittsburgh Sleep Quality Index in persons with traumatic brain injury. A NIDRR TBI model systems module study. | Sleep disturbances are common following traumatic brain injury (TBI). The Pittsburgh Sleep Quality Index (PSQI) is a widely used measure of sleep quality that has been used in numerous populations. Although this measure has been used in TBI research, there are few studies examining the psychometric properties in this p... | 25,260,230 | [
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Is depression associated with an increased risk of treatment-resistant epilepsy? Research strategies to investigate this question. | Persons with epilepsy (PWE) have a higher risk of developing depressive disorders (DDs), and people with primary DD have an increased risk of developing epilepsy. Furthermore, a lifetime history of DD has been associated with a worse response of the seizure disorder to pharmacotherapy and epilepsy surgery. The first pa... | 25,260,238 | [
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Reversing song behavior phenotype: Testosterone driven induction of singing and measures of song quality in adult male and female canaries (Serinus canaria). | In songbirds, such as canaries (Serinus canaria), the song control circuit has been shown to undergo a remarkable change in morphology in response to exogenous testosterone (T). It is also well established that HVC, a telencephalic nucleus involved in song production, is significantly larger in males than in females. T... | 25,260,250 | [
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Pathogenesis of hepatocellular carcinoma according to aetiology. | Hepatocellular carcinoma is related to various etiologies including hepatitis B, hepatitis C, high alcohol intake, aflatoxin B1 and metabolic syndrome. Most of the time HCC developed on cirrhosis. Consequently, the mechanisms of carcinogenesis of these different risk factors are difficult to separate from the events le... | 25,260,319 | [
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The effect of social stress on salivary trace elements. | Social stress can alter the saliva in favor of metabolism of trace elements. This study aimed to assess the effect of social stress on salivary copper (Cu), zinc (Zn), manganese (Mn), and iron (Fe) contents in dental students before and after a comprehensive English test. Twelve students with an average age of 27 years... | 25,260,321 | [
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Acute onset of encephalomyelitis with atypical lesions associated with dual infection of Sarcocystis neurona and Toxoplasma gondii in a dog. | A two-year-old male, neutered, basset hound-beagle mix with progressive neurological impairment was examined postmortem. Grossly, the dog had multiple raised masses on the spinal cord between nerve roots. Microscopically, the dog had protozoal myeloencephalitis. Toxoplasma gondii and Sarcocystis neurona were detected i... | 25,260,332 | [
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Glycemic control parameters in insulin-naïve patients with uncontrolled type 2 diabetes referred to endocrinologists, and degree of implementation of the national Spanish consensus for the management of hyperglycemia. | To assess blood glucose in patients with uncontrolled type 2 diabetes mellitus treated with oral antidiabetic drugs in primary care at the time of referral to specialized endocrinologists, and the degree of implementation of the national consensus guidelines of the Spanish Society of Diabetes by evaluating steps one (S... | 25,260,336 | [
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Head computed tomography in the emergency department: a collection of easily missed findings that are life-threatening or life-changing. | The use of noncontrast head computed tomography (CT) has become commonplace in the emergency department (ED) as a means of screening for a wide variety of pathologies. Approximately 1 in 14 ED patients receives a head CT scan, and analyzing and interpreting this high volume of images in a timely manner is a daily chall... | 25,260,346 | [
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Metabolic network prediction through pairwise rational kernels. | Metabolic networks are represented by the set of metabolic pathways. Metabolic pathways are a series of biochemical reactions, in which the product (output) from one reaction serves as the substrate (input) to another reaction. Many pathways remain incompletely characterized. One of the major challenges of computationa... | 25,260,372 | [
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The risk of heart failure associated with the use of noninsulin blood glucose-lowering drugs: systematic review and meta-analysis of published observational studies. | Patients with type 2 diabetes mellitus (T2DM) are at high risk of heart failure. A summary of the effects of blood glucose-lowering drugs other than glitazones on the risk of heart failure in routine clinical practice is lacking. The objective of this study was to conduct a systematic review and meta-analysis of observ... | 25,260,374 | [
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The preclinical discovery of lofexidine for the treatment of opiate addiction. | Lofexidine is one therapeutic option used for treating the onslaught of sympathetic outflow that typically commences upon induction of opiate withdrawal. It was approved for opiate detoxification in the UK, most of EU, and a select few countries worldwide during the 1980s and the 90s. Within the US and Canada, however,... | 25,260,380 | [
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Deoxyelephantopin impairs growth of cervical carcinoma SiHa cells and induces apoptosis by targeting multiple molecular signaling pathways. | Deoxyelephantopin, a sesquiterpene lactone extracted and purified from Elephantopus scaber, has been shown to exhibit antitumor and hepatoprotective activities. The purpose of this study was to investigate the antiproliferative and apoptosis-inducing properties of deoxyelephantopin in SiHa cells and to elucidate the un... | 25,260,383 | [
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Beliefs About Sex and Parent-Child-Church Sex Communication Among Church-Based African American Youth. | Parent-child sex communication has been shown to be protective against sexual risk among African American youth. The current study sought to use the theory of planned behavior as a framework for focus group discussions (N = 54 youth participants aged 12-19 years) to explore church youths' (a) sex beliefs and values (at... | 25,260,385 | [
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[Extracorporeal pulmonary support procedures in intensive care medicine 2014]. | In recent years a rapid expansion of extracorporeal devices for support of severe lung failure has been witnessed. Systems for veno-venous extracorporeal membrane oxygenation (VV-ECMO) or for extracorporeal carbon dioxide elimination are distinguished depending on the indications. The state of the art of extracorporeal... | 25,260,398 | [
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Cytomegalovirus disease in patients with glomerular diseases treated by immunosuppressive treatment. | Cytomegalovirus (CMV) infection is an important complication in organ and bone marrow recipients as well as patients infected with HIV. Although screening and prophylaxis have been defined in these patients, there are few data about the frequency of CMV disease in glomerular diseases treated by immunosuppression. We re... | 25,260,403 | [
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Certification of a reference material of metal content in atmospheric particles deposited on filters. | Air quality is one of the areas in Europe where a series of EU Directives have been published with the aim of achieving improved long-term and harmonised air quality objectives across the European Union. This paper describes the production of a certified reference material, aiming to support QA/QC programmes of analyti... | 25,260,410 | [
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Hepatic portal venous gas in Crohn's disease. | Hepatic portal venous gas (HPVG) is a rare finding that has only been reported previously among 25 patients with Crohn's disease in the English literature. We present a case of a 27-year-old woman with Crohn's disease who presented with fever, abdominal pain and per rectal bleeding and was found to have HPVG at the tim... | 25,260,428 | [
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Global left atrial strain in the prediction of sinus rhythm maintenance after catheter ablation for atrial fibrillation. | Left atrial (LA) strain is a sensitive measure of LA mechanics. However, its relationship with rhythm outcomes after catheter ablation in patients with atrial fibrillation (AF) is not well established. The aim of this study was to evaluate whether baseline LA global longitudinal strain (LAε) predicts rhythm outcomes in... | 25,260,436 | [
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Role of stress echocardiography in operated fallot: feasibility and detection of right ventricular response. | Patients with repaired tetralogy of Fallot often present residual hemodynamic abnormalities leading to right ventricular (RV) burden. Semisupine exercise echocardiography (Ex-Echo) is a validated method for diagnosis and prognosis in ischemic and valvular heart diseases and has potential for the evaluation of RV burden... | 25,260,437 | [
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HuMOVE: a low-invasive wearable monitoring platform in sexual medicine. | To investigate an accelerometer-based wearable system, named Human Movement (HuMOVE) platform, designed to enable quantitative and continuous measurement of sexual performance with minimal invasiveness and inconvenience for users. Design, implementation, and development of HuMOVE, a wearable platform equipped with an a... | 25,260,456 | [
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Modeling T cell receptor recognition of CD1-lipid and MR1-metabolite complexes. | T cell receptors (TCRs) can recognize diverse lipid and metabolite antigens presented by MHC-like molecules CD1 and MR1, and the molecular basis of many of these interactions has not been determined. Here we applied our protein docking algorithm TCRFlexDock, previously developed to perform docking of TCRs to peptide-MH... | 25,260,513 | [
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Incidence of short stature at 3 years of age in late preterm infants: a population-based study. | This study aimed to investigate the incidence of short stature at 3 years of age in a Japanese cohort of late preterm infants who were born at 34-36 weeks' gestational age (GA). We compared these late preterm infants with term infants (37-41 weeks' GA), and evaluated the effect of birth weight on the incidence of short... | 25,260,516 | [
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Effect of postmortem aging on marination performance of broiler breast pectoralis major categorized by color lightness. | The objective was to evaluate the effect of postmortem aging on marination performance of early-deboned chicken breast fillets (pectoralis major) with different color lightness. Effects of marination on muscle shear force were also determined. Early-deboned (2 h postmortem) broiler butterfly fillets were visually selec... | 25,260,524 | [
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Variation in pregnancy intendedness across U.S. women's pregnancies. | How stable are women's pregnancy intentions across their reproductive lifespans? Are there demographic, social, or attitudinal characteristics that are associated with differing pregnancy intentions patterns? Patterns of intendedness across pregnancies were examined using a sample of 3,110 women ages 25-45 who have bee... | 25,260,541 | [
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Sacs knockout mice present pathophysiological defects underlying autosomal recessive spastic ataxia of Charlevoix-Saguenay. | Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS [MIM 270550]) is an early-onset neurodegenerative disorder caused by mutations in the SACS gene. Over 170 SACS mutations have been reported worldwide and are thought to cause loss of function of sacsin, a poorly characterized and massive 520 kDa protein.... | 25,260,547 | [
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Dissociable effects of anterior and mediodorsal thalamic lesions on spatial goal-directed behavior. | Goal-directed behaviors are thought to be supported by a neural circuit encompassing the prefrontal cortex, the dorsomedial striatum, the amygdala, and, as more recently suggested, the limbic thalamus. Since evidence indicates that the various thalamic nuclei contribute to dissociable functions, we directly compared th... | 25,260,555 | [
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Dorsal hippocampus and medial prefrontal cortex each contribute to the retrieval of a recent spatial memory in rats. | Systems-level consolidation models propose that recent memories are initially hippocampus-dependent. When remote, they are partially or completely dependent upon the medial prefrontal cortex (mPFC). An implication of the mPFC in recent memory, however, is still debated. Different amounts of muscimol (MSCI 0, 30, 50, 80... | 25,260,556 | [
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A versatile bioink for three-dimensional printing of cellular scaffolds based on thermally and photo-triggered tandem gelation. | Layer-by-layer bioprinting is a logical choice for the fabrication of stratified tissues like articular cartilage. Printing of viable organ replacements, however, is dependent on bioinks with appropriate rheological and cytocompatible properties. In cartilage engineering, photocrosslinkable glycosaminoglycan-based hydr... | 25,260,606 | [
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Endothelial nitric oxide synthase mediates the nitric oxide component of reflex cutaneous vasodilatation during dynamic exercise in humans. | Recent data suggests neuronal nitric oxide synthase (nNOS) mediates the NO component of reflex cutaneous vasodilatation with passive heat stress. We tested the hypothesis that nNOS inhibition would attenuate reflex cutaneous vasodilatation during sustained dynamic exercise in young healthy humans. All subjects first pe... | 25,260,636 | [
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Epigenetic pathways regulating bone homeostasis: potential targeting for intervention of skeletal disorders. | Epigenetic regulation utilizes different mechanisms to convey heritable traits to progeny cells that are independent of DNA sequence, including DNA silencing, post-translational modifications of histone proteins, and the post-transcriptional modulation of RNA transcript levels by non-coding RNAs. Although long non-codi... | 25,260,661 | [
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HTSeq--a Python framework to work with high-throughput sequencing data. | A large choice of tools exists for many standard tasks in the analysis of high-throughput sequencing (HTS) data. However, once a project deviates from standard workflows, custom scripts are needed. We present HTSeq, a Python library to facilitate the rapid development of such scripts. HTSeq offers parsers for many comm... | 25,260,700 | [
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CpA/CpG methylation of CiMDA5 possesses tight association with the resistance against GCRV and negatively regulates mRNA expression in grass carp, Ctenopharyngodon idella. | Melanoma differentiation-associated gene 5 (MDA5) plays a crucial role in recognizing intracellular viral infection, activating the interferon regulatory factor pathways as well as inducing antiviral response. While the antiviral regulatory mechanism of MDA5 remains unclear. In the present study, CiMDA5 (Ctenopharyngod... | 25,260,715 | [
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The radix entomolaris and paramolaris: a micro-computed tomographic study of 3-rooted mandibular first molars. | The morphology of the supernumerary third root (radix) in mandibular first molars was examined by micro-computed tomography (μCT) scanning. Nineteen permanent mandibular first molars with radix were scanned in a μCT device to evaluate their morphology with respect to root length, root curvature direction, location of r... | 25,260,733 | [
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In vitro evaluation of antibacterial effect of AH Plus incorporated with quaternary ammonium epoxy silicate against Enterococcus faecalis. | The purpose of this study was to evaluate the in vitro antibacterial effect of AH Plus (Dentsply, DeTrey, Konstanz, Germany) incorporated with quaternary ammonium epoxy silicate (QAES) against Enterococcus faecalis. QAES particles were synthesized by the cocondensation of tetraethoxysilane with 2 trialkoxysilanes (3-[t... | 25,260,732 | [
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An in vitro comparison of apically extruded debris and instrumentation times with ProTaper Universal, ProTaper Next, Twisted File Adaptive, and HyFlex instruments. | The purpose of this study was to compare the in vitro amount of apically extruded debris with new endodontic rotary nickel-titanium instruments. Sixty mandibular premolars were instrumented up to size 25 using ProTaper Universal (Dentsply Maillefer, Ballaigues, Switzerland), ProTaper Next (Dentsply Maillefer), Twisted ... | 25,260,737 | [
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Maxillary central incisor with type V canal morphology: case report and literature review. | It is widely accepted that the permanent maxillary central incisor almost invariably has a single canal. This case reports a maxillary central incisor canal morphology that differs from this predominant form, a single-rooted permanent maxillary central incisor with 1 main canal that separated into 2 distinct canals in ... | 25,260,744 | [
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Quantitative forecasting of PTSD from early trauma responses: a Machine Learning application. | There is broad interest in predicting the clinical course of mental disorders from early, multimodal clinical and biological information. Current computational models, however, constitute a significant barrier to realizing this goal. The early identification of trauma survivors at risk of post-traumatic stress disorder... | 25,260,752 | [
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Forkhead Box F1 represses cell growth and inhibits COL1 and ARPC2 expression in lung fibroblasts in vitro. | Aberrant expression of master phenotype regulators or alterations in their downstream pathways in lung fibroblasts may play a central role in idiopathic pulmonary fibrosis (IPF). Interrogating IPF fibroblast transcriptome datasets, we identified Forkhead Box F1 (FOXF1), a DNA-binding protein required for lung developme... | 25,260,753 | [
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Abandoning the dead donor rule? A national survey of public views on death and organ donation. | Brain dead organ donors are the principal source of transplantable organs. However, it is controversial whether brain death is the same as biological death. Therefore, it is unclear whether organ removal in brain death is consistent with the 'dead donor rule', which states that organ removal must not cause death. Our a... | 25,260,779 | [
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Implication of metastasis suppressor gene, Kiss-1 and its receptor Kiss-1R in colorectal cancer. | Kiss-1 and Kiss-1R have been suggested as a novel pair of metastasis suppressors for several human solid tumours, however, their role in colorectal cancer remains largely unknown. Therefore, the aim of this study was to investigate the role and signal transduction of Kiss-1 and Kiss-1R in colorectal cancer. Ribozyme tr... | 25,260,785 | [
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Use of a targeted, combinatorial next-generation sequencing approach for the study of bicuspid aortic valve. | Bicuspid aortic valve (BAV) is the most common type of congenital heart disease with a population prevalence of 1-2%. While BAV is known to be highly heritable, mutations in single genes (such as GATA5 and NOTCH1) have been reported in few human BAV cases. Traditional gene sequencing methods are time and labor intensiv... | 25,260,786 | [
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Molecular characterization of carbapenem-resistant Enterobacteriaceae at a tertiary care laboratory in Mumbai. | Carbapenem-hydrolyzing β-lactamases are increasingly reported worldwide, leading to therapeutic failure. In an era where the drug development pipeline is stagnant, it is crucial to preserve current classes of antibiotics to help fight against infection caused by multidrug-resistant organisms (MDROs), by practicing a ra... | 25,260,787 | [
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Borealin/Dasra B is overexpressed in colorectal cancers and contributes to proliferation of cancer cells. | Borealin/Dasra B, also called cell division cycle associated 8, is a member of the chromosomal passenger complex and plays a crucial role during mitosis and cell division. The expression of this gene has been investigated in several kinds of cancers, but its role in colorectal cancers (CRC) remains to be elucidated. In... | 25,260,804 | [
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The novel long noncoding RNA AC138128.1 may be a predictive biomarker in gastric cancer. | It is well known that the differential expression of long noncoding RNA (lncRNA) plays critical roles in carcinogenesis. However, the significance of lncRNA in the diagnosis of gastric cancer (GC) remains largely unknown. The goal of this study was to determine the expression level of AC138128.1, a novel lncRNA, in GC ... | 25,260,808 | [
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Free light chains in patients with acute heart failure secondary to atherosclerotic coronary artery disease. | Increased combined free light chains (cFLCs) are strongly prognostic of death in general populations and in patients with chronic kidney disease, but scarce data are available on cFLC in heart failure (HF). The aim of this study was to assess the dynamics and prognostic significance of cFLC levels in patients after adm... | 25,260,814 | [
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Structural studies suggest a peptidoglycan hydrolase function for the Mycobacterium tuberculosis Tat-secreted protein Rv2525c. | Among the few proteins shown to be secreted by the Tat system in Mycobacterium tuberculosis, Rv2525c is of particular interest, since its gene is conserved in the minimal genome of Mycobacterium leprae. Previous evidence linked this protein to cell wall metabolism and sensitivity to β-lactams. We describe here the crys... | 25,260,828 | [
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Pasireotide versus continued treatment with octreotide or lanreotide in patients with inadequately controlled acromegaly (PAOLA): a randomised, phase 3 trial. | Many patients with acromegaly do not achieve biochemical control despite receiving high doses of the first-generation somatostatin analogues octreotide or lanreotide. In the PAOLA trial, we aimed to assess the efficacy and safety of two different doses of the somatostatin analogue pasireotide long-acting release compar... | 25,260,838 | [
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Use of generalized linear mixed models for network meta-analysis. | In the past decade, a new statistical method-network meta-analysis-has been developed to address limitations in traditional pairwise meta-analysis. Network meta-analysis incorporates all available evidence into a general statistical framework for comparisons of multiple treatments. Bayesian network meta-analysis, as pr... | 25,260,872 | [
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Overexpression of mitochondrial antioxidant manganese superoxide dismutase (MnSOD) provides protection against AZT- or 3TC-induced endothelial dysfunction. | Nucleoside reverse transcriptase inhibitors (NRTIs) are considered the backbone of current combination therapies for HIV. These therapies have significantly decreased mortality and morbidity in HIV-infected patients, but some are associated with cardiovascular complications, including endothelial dysfunction, an early ... | 25,260,898 | [
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Heterotrophic communities supplied by ancient organic carbon predominate in deep fennoscandian bedrock fluids. | The deep subsurface hosts diverse life, but the mechanisms that sustain this diversity remain elusive. Here, we studied microbial communities involved in carbon cycling in deep, dark biosphere and identified anaerobic microbial energy production mechanisms from groundwater of Fennoscandian crystalline bedrock sampled f... | 25,260,922 | [
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Effect of 30 years of road traffic abandonment on epiphytic moss diversity. | Road traffic emits a cocktail of pollutants that can influence the vegetation and plant diversity in neighboring areas. However, the recovery potential of bryophytes after traffic abandonment is still little explored. In addition, the effects of the main pollutants of road verges, such as metals and salinity, on moss f... | 25,260,925 | [
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CRISPR/Cas9 mediated generation of stable chondrocyte cell lines with targeted gene knockouts; analysis of an aggrecan knockout cell line. | The Swarm rat chondrosarcoma (RCS) cell lines derived from a spontaneous neoplasm in a rat spine several decades ago have provided excellent models of chondrosarcoma tumor development. In addition the robust chondrocyte phenotype (expression of a large panel of genes identical to that seen in normal rat cartilage) and ... | 25,260,929 | [
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Engineered decellularized matrices to instruct bone regeneration processes. | Despite the significant progress in the field of bone tissue engineering, cell-based products have not yet reached the stage of clinical adoption. This is due to the uncertain advantages from the standard-of-care, combined with challenging cost-and regulatory-related issues. Novel therapeutic approaches could be based ... | 25,260,931 | [
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Multimodal imaging in autism: an early review of comprehensive neural circuit characterization. | There is accumulating evidence that the neurobiology of autism spectrum disorders (ASD) is linked to atypical neural communication and connectivity. This body of work emphasizes the need to characterize the function of multiple regions that comprise neural circuits rather than focusing on singular regions as contributi... | 25,260,934 | [
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Replicable Facets of Positive Emotionality and Their Relations to Psychopathology. | General individual differences in positive emotionality are negatively related to depression, social anxiety, and schizotypy/schizophrenia, and positively related to mania. However, the structure of positive emotionality remains unclear at the facet level, as there are significant disparities in the types of content as... | 25,260,942 | [
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Prognostic impact of pulmonary artery systolic pressure in patients undergoing transcatheter aortic valve replacement for aortic stenosis. | Baseline pulmonary hypertension (PH) is a predictor of poor outcomes in patients with severe aortic stenosis (AS). Surgical aortic valve replacement is thought to alleviate PH. The aim of this study was to determine the prognostic impact of PH in patients who underwent transcatheter aortic valve replacement (TAVR). An ... | 25,260,946 | [
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Usefulness of Beta blockade in contemporary management of patients with stable coronary heart disease. | Considerable progress has been made over the last few decades in the management of clinically stable coronary heart disease (SCHD), including improvements in interventions (e.g., percutaneous revascularization), pharmacological management, and risk factor control (e.g., smoking, diet, activity level, hypercholesterolem... | 25,260,949 | [
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The effect of age on the structural properties of human ribs. | Traumatic injury from motor vehicle crashes is a major cause of morbidity and mortality in the United States. The thorax is particularly at risk in motor vehicle crashes and is studied extensively by the injury biomechanics community. Unfortunately, most samples used in such research generally do not include children o... | 25,260,951 | [
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Fatigue and carnitine levels over multiple cycles of chemotherapy in children and adolescents. | Fatigue in childhood cancer is a pervasive and distressing symptom described as a "lack of energy". Carnitine is a micronutrient used to transport long chain fatty acids into muscle mitochondria. Some chemotherapy drugs interfere with the carnitine network. Both carnitine and fatigue relate to physical energy and may b... | 25,260,954 | [
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Interventional radiology in infancy. | Interventional radiology (IR) is an emerging sub-speciality within paediatric medicine. In adult care, IR is largely centred on the management of vascular disease but in paediatric practice, IR applications are varied and increasingly innovative, making this an exciting field to be a part of. IR has a central role both... | 25,260,962 | [
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Proton radiotherapy for pediatric tumors: review of first clinical results. | Radiation therapy is a part of multidisciplinary management of several childhood cancers. Proton therapy is a new method of irradiation, which uses protons instead of photons. Proton radiation has been used safely and effectively for medulloblastoma, primitive neuro-ectodermal tumors, craniopharyngioma, ependymoma, ger... | 25,260,976 | [
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Influence of pneumoperitoneum pressure on surgical field during robotic and laparoscopic surgery: a comparative study. | Studies on the influence of CO₂ pneumoperitoneum on the abdominal cavity during robotic procedures are lacking. This is the first study to evaluate surgical field modifications related to CO₂ pressure, during laparoscopic and robotic surgery. Consecutive patients scheduled for laparoscopic or robotic hysterectomy were ... | 25,260,990 | [
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Microstructural brain development between 30 and 40 weeks corrected age in a longitudinal cohort of extremely preterm infants. | Diffusion tensor imaging (DTI) is frequently used to assess brain development in preterm infants. This study investigates maturational changes in diffusivity measures in 122 regions of the brain between 30 and 40 weeks postmenstrual age (PMA) using the neonatal atlas of Oishi and colleagues (Oishi et al., 2011). Forty ... | 25,261,000 | [
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The three essentials for accident prevention. | This article was written by Crystal Eastman when she was Secretary of the New York Commission on Employers' Liability and Causes of Industrial Accidents, Unemployment, and Lack of Farm Labor. It was published in July of 1911, in Volume 38, Number 1 of the Annals of the American Academy of Political and Social Science, ... | 25,261,022 | [
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... |
Charlotte Todes Stern, staff member of the Workers' Health Bureau: "we were in advance of our time". | Charlotte Todes Stern (5/5/1897-11/15/1996) was a radical activist for most her life, beginning with her introduction to YPSL (Young People's Socialist League) during her college years. In 1923, Todes Stern became a staff member of the Workers' Health Bureau (WHB), and two years later she became their Organizing Secret... | 25,261,027 | [
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The low-dose atorvastatin and valsartan combination effectively protects the arterial wall from atherogenic diet-induced impairment in the guinea pig. | New preventive strategies for atherosclerosis are needed. In this study, we tested whether a new therapeutic approach consisting of low-dose treatment with a statin and sartan combination could prevent atherogenic diet-induced impairment of the arterial wall in guinea pigs. Twenty-five Dunkin-Hartley guinea pigs were r... | 25,261,034 | [
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A novel dopamine D3 receptor antagonist YQA14 inhibits methamphetamine self-administration and relapse to drug-seeking behaviour in rats. | Growing preclinical evidence suggests that dopamine D3 receptor antagonists are promising for the treatment of addiction. We have previously reported a novel dopamine D3 receptor antagonist YQA14 with better pharmacokinetic behaviours and pharmacotherapeutic efficacy than other tested compounds in attenuating the rewar... | 25,261,038 | [
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What drives poor functioning in the at-risk mental state? A systematic review. | Transition to psychotic disorder has been the traditional outcome of interest for research in the at-risk mental state (ARMS). However, there is growing recognition that individuals with ARMS may function poorly regardless of whether they develop psychosis. We aimed to review the literature to determine whether there a... | 25,261,041 | [
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Development of a multiplex PCR assay for identification of Klebsiella pneumoniae hypervirulent clones of capsular serotype K2. | Hypervirulent Klebsiella pneumoniae isolates of capsular serotype K2 (hvKP-K2) that cause community-acquired invasive infections represent several unrelated clones, which all belong to phylogenetic group KpI. These clones can be recognized using multilocus sequence typing and genomic analyses, but no rapid method curre... | 25,261,063 | [
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Factors affecting in vitro maturation of alpaca (Lama paco) oocytes. | The present study utilized a 2×2×2 factorial design examining age (old vs. young), follicle size (≥2mm vs. <2mm) and media supplementation (with or without fetal bovine serum [FBS]) to determine factors that might affect in vitro maturation of alpaca oocytes. We hypothesized that oocytes collected from follicles ≥2m... | 25,261,077 | [
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0.3539948,
0.1930166,
0.1319764,
-0.3019502,
... |
Kefir: a multifaceted fermented dairy product. | Kefir is a fermented dairy beverage produced by the actions of the microflora encased in the "kefir grain" on the carbohydrates in the milk. Containing many bacterial species already known for their probiotic properties, it has long been popular in Eastern Europe for its purported health benefits, where it is routinely... | 25,261,107 | [
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0.1362973,
0.2524586,
0.1201003,
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0.1271907,
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0.2225522,
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Indications for in vitro fertilization at a public center for reproductive health in Campinas, Brazil. | To assess the sociodemographic profile and gynecologic and obstetric characteristics of women referred to a public reference center in Campinas, Brazil, for in vitro fertilization (IVF). Women referred between April 1, 2008, and October 31, 2009, were eligible for inclusion in a cross-sectional study. Participants were... | 25,261,108 | [
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0.00732006,
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... |
Evaluation of hypopharyngeal suction to eliminate aspiration: the Retro-Esophageal Suction (REScue) catheter. | Profound oropharyngeal dysphagia (OPD) is common and costly. Treatment options are limited. The purpose of this investigation was to evaluate the utility of hypopharyngeal suction at the upper esophageal sphincter (UES) to eliminate aspiration. Five different catheters were passed retrograde up the esophagus and positi... | 25,261,119 | [
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0.002030064,
0.05299775,
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0.2840747,
-0.01... |
A cross-sectional survey study of nurses' self-assessed competencies in obstetric and surgical postanesthesia care units. | The purpose of this study was to identify priorities to guide development of an obstetric PACU continuing education curriculum. A cross-sectional, survey design was used. A total of 54 obstetric nurses and 68 perianesthesia Phase I nurses at an academic, tertiary care center completed online surveys for self-assessment... | 25,261,142 | [
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... |
SIRRACT: An International Randomized Clinical Trial of Activity Feedback During Inpatient Stroke Rehabilitation Enabled by Wireless Sensing. | Walking-related disability is the most frequent reason for inpatient stroke rehabilitation. Task-related practice is a critical component for improving patient outcomes. To test the feasibility of providing quantitative feedback about daily walking performance and motivating greater skills practice via remote sensing. ... | 25,261,154 | [
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0.06621142,
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0.03738721,
0.0409... |
[Early goal directed therapy in severe sepsis]. | The treatment of patients with severe sepsis and septic shock continues to evolve. Recent studies have enunciated the benefit of early goal-directed therapy (EGDT) during the first 6 h after recognition of the condition. With EGDT a reduction in mortality of over 16% was shown over standard care. Thereafter the compone... | 25,261,188 | [
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0.1010653,
0.1113685,
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0.1213496,... |
The SNAPSHOT study protocol: SNAcking, Physical activity, Self-regulation, and Heart rate Over Time. | The cognitive processes responsible for effortful behavioural regulation are known as the executive functions, and are implicated in several factors associated with behaviour control, including focussing on tasks, resisting temptations, planning future actions, and inhibiting prepotent responses. Similar to muscles, th... | 25,261,200 | [
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0.03153971,
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0.2172509,
-0.2152826,
0.3924856,
-0.01981705,
... |
Evidence-based psychotherapy for the prevention and treatment of first-episode psychosis. | The aim of psychotherapy among individuals at clinical high risk (CHR) for psychosis is to prevent transition to full-blown psychosis. Psychotherapy in individuals with a first-episode psychosis (FEP) aims to reduce relapse rates. Remission of (pre-) psychotic symptoms, psychosocial functioning, quality of life, comorb... | 25,261,211 | [
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0.3113743,
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0.2863331,
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0.5068516,
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Static and dynamic tibial translation before, 5 weeks after, and 5 years after anterior cruciate ligament reconstruction. | To evaluate static and dynamic tibial translation before, 5 weeks after, and 5 years after anterior cruciate ligament (ACL) reconstruction. To explore whether static and dynamic tibial translation are correlated. Ten patients undergoing quadruple hamstring tendon graft ACL reconstruction were evaluated before, 5 weeks ... | 25,261,221 | [
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0.1196586,
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0.2678356,
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0.3216309,
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-0.2558087,
0.05030003,
0.31420... |
Return to play after all-inside meniscal repair in competitive football players: a minimum 5-year follow-up. | The purpose of this study was to report the mid-to-long-term return to sports after all-inside meniscal repair in competitive football players. All football players undergoing all-inside meniscal repair with a minimum Tegner activity score of 9 and minimum follow-up of 5 years were eligible for inclusion. Patients were... | 25,261,222 | [
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0.2102595,
0.1003924,
0.005194423,
... |
In vivo localization of ⁹⁰Y and ¹⁷⁷Lu radioimmunoconjugates using Cerenkov luminescence imaging in a disseminated murine leukemia model. | Cerenkov radiation generated by positron-emitting radionuclides can be exploited for a molecular imaging technique known as Cerenkov luminescence imaging (CLI). Data have been limited, however, on the use of medium- to high-energy β-emitting radionuclides of interest for cancer imaging and treatment. We assessed the us... | 25,261,237 | [
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0.05475996,
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0.3800623,
0.2861083,
0.2995215,
0.02398362... |
GPx2 suppression of H2O2 stress links the formation of differentiated tumor mass to metastatic capacity in colorectal cancer. | Colorectal tumorigenesis is accompanied by the generation of oxidative stress, but how this controls tumor development is poorly understood. Here, we studied how the H2O2-reducing enzyme glutathione peroxidase 2 (GPx2) regulates H2O2 stress and differentiation in patient-derived "colonosphere" cultures. GPx2 silencing ... | 25,261,240 | [
-0.02718462,
0.02769233,
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0.03687007,
0.1518323,
0.2977444,
0.09891566,
-0.019205... |
Sulfite-oxidizing enzymes. | Sulfite-oxidizing enzymes (SOEs) are molybdenum enzymes that exist in almost all forms of life where they carry out important functions in protecting cells and organisms against sulfite-induced damage. Due to their nearly ubiquitous presence in living cells, these enzymes can be assumed to be evolutionarily ancient, an... | 25,261,289 | [
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0.129995,
0.1098066,
0.3445345,
0.1543592,
0.5354562,
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Applying Adverse Outcome Pathways (AOPs) to support Integrated Approaches to Testing and Assessment (IATA). | Chemical regulation is challenged by the large number of chemicals requiring assessment for potential human health and environmental impacts. Current approaches are too resource intensive in terms of time, money and animal use to evaluate all chemicals under development or already on the market. The need for timely and... | 25,261,300 | [
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0.1768441,
0.1663237,
0.4863487,
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... |
Molecular identification and quantification of human rhinoviruses in respiratory samples. | PCR-based molecular assays have become standard diagnostic procedures for the identification and quantification of human rhinoviruses (HRVs) and other respiratory pathogens in most, if not all, clinical microbiology laboratories. Molecular assays are significantly more sensitive than traditional culture-based and serol... | 25,261,304 | [
-0.1578301,
-0.03597165,
-0.3162774,
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-0.06882134,
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0.08010642,
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0.1692843,
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0.1003117,
0.02772189,
-0.0281152,
0.2017792,
0.03760723,
-0.233404... |
Endoscopic endonasal transsellar approach for laterally extended pituitary adenomas: volumetric analysis of cavernous sinus invasion. | The authors conducted a statistical analysis of surgical results of the endoscopic endonasal transsellar approach to provide quantitative indices for selection of the approach in the treatment of laterally extended pituitary adenomas. Surgical results of 25 patients with laterally extended pituitary adenomas of Knosp g... | 25,261,331 | [
-0.1533543,
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0.2556711,
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0.08063266,
0.1534038,
0.1145827,... |
Predicting carrier-mediated hepatic disposition of rosuvastatin in man by scaling from individual transfected cell-lines in vitro using absolute transporter protein quantification and PBPK modeling. | In contrast to primary hepatocytes, estimating carrier-mediated hepatic disposition by using a panel of single transfected cell-lines provides direct information on the contribution of the individual transporters to the net disposition. The most direct way to correct for differences in transporter abundance between cel... | 25,261,337 | [
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0.02314014,
0.3149542,
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-... |
Loss of the obscurin-RhoGEF downregulates RhoA signaling and increases microtentacle formation and attachment of breast epithelial cells. | Obscurins are RhoGEF-containing proteins whose downregulation has been implicated in the development and progression of breast cancer. Herein, we aim to elucidate the mechanism for increased motility of obscurin-deficient cells. We show that shRNA-mediated obscurin downregulation in MCF10A cells leads to >50% reduct... | 25,261,370 | [
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0.01975817,
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-0.1451971,
0.4083958,
-0.04196578,
0.4853706,
0.1534904,
-0.0837664,
... |
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