title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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The effects of linoleate hydroperoxide on respiration and oxidative phosphorylation of rat liver mitochondria. | Linoleate hydropepoxide, purified by silica gel chromatography and at concentrations 70-100 nmol/mg mitochondrial protein, activated state 4 respiration and Mg-ATPase activity of mitochondria to levels of 80% and 25%, respectively, of those induced by 300 microM DNP, and completely inhibited oxidative phosphorylation. ... | 159,292 | [
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Isolation and characterization of mucopolysaccharides from rat liver mitochondria. | Mucopolysaccharides were isolated from rat liver mitochondria which had been labeled with 35S-sulfate. They were prepared from trichloroacetic acid (TCA)-insoluble and -soluble fractions of lipid-free mitochondria. These fractions were digested with pronase exhaustively, and the mucopolysaccharides were recovered in th... | 159,293 | [
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Studies of immune functions of patients with systemic lupus erythematosus. T-cell subsets and antibodies to T-cell subsets. | Antibodies to T cells present in the plasma of patients with active systemic lupus erythematosus (SLE) plus complement are able to eliminate concanavalin A-induced suppressor function for the proliferative responses of T cells to allogeneic lymphocytes (MLR) and of B cells to pokeweed mitogen (PWM). Such antibodies wer... | 159,312 | [
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Echocardiographic abnormalities in infants of diabetic mothers. | In order to evaluate the presence of myocardial hypertrophy and/or abnormalities of postnatal cardiovascular adaptation, echocardiograms were performed on 34 infants of diabetic mothers. Based on cardiopulmonary assessment, the IDM were divided into three groups: Group I with congestive heart failure predominating: Gro... | 159,351 | [
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Isolation and identification of bacteriophage phi X174 prohead. | The morphogenesis of bacteriophage phi X174 has been investigated by using an in vitro DNA synthesizing system. An extract of a B-mutant-infected cell is capable of synthesizing infectious phage in vitro when the B gene function is provided by the addition of an ammonium sulfate fraction of a C-mutant-infected-cell ext... | 159,449 | [
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Effect of chinoform on the function of biological membranes. | To investigate the mechanism by which the toxic effect of chinoform (5-chloro-7-iodo-8-quinolinol) develops, its action on the function of biological membranes was examined. Findings were: 1. Chinoform induced K+ release from red cells. This effect was increased by prior addition of Mg2+ and decreased by albumin, ruthe... | 159,463 | [
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[The treatment of spastic equinovarus in the adult by transplantation of peroneus brevis and lengthening of the tendo-calcaneus (author's transl)]. | A new technique is proposed for the treatment of spastic equinovarus foot. After lengthening the tendo calcaneus, the peroneus brevis tendon is divided at the junction with its muscle belly and the distal end of the tendon is transferred through the interosseous membrane to be sutured to the tendo calcaneus. This techn... | 159,480 | [
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Severe hypersensitivity reactions to allopurinol. | The frequency of severe reactions to allopurinol has probably been underestimated. A retrospective study encompassing a five-year period has yielded 20 patients with severe hypersensitivity reactions to allopurinol. Patients with preexisting renal impairment or who were receiving concomitant thiazide diuretics appeared... | 159,491 | [
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The use of vasodilator agents in the treatment of heart failure. | In cardiac failure unresponsive to digoxin and diuretics, afterload reduction brings about a dramatic increase in cardiac output, renal perfusion and responsiveness to diuretics; furthermore, the decrease in venous pressure relieves the dyspnoea. Intravenous vasodilators should only be used when sophisticated haemodyna... | 159,502 | [
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The plasminogen content of commercial preparations and of normal donor plasma in relation to the plasmin content of the 1st international plasmin reference preparation. | Kabi human plasminogen and plasmin and two Behringwerke preparations of human plasminogen were examined for antigen content, purity and specific activity with the 1st International W.H.O. human plasmin reference preparation and with the plasminogen content of an 8 donor normal plasma pool. In relation to the plasminoge... | 159,512 | [
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Ineffectiveness of the Doppler Ophthalmic Test (DOT) in post-endarterectomy evaluation. | In an effort to evaluate the effectiveness of the Doppler Ophthalmic Test (DOT) following carotid endarterectomy, a large group of patients was examined both pre- and postoperatively with non-invasive techniques. The DOT, which has proven to be a useful non-invasive diagnostic test for the determination of significant ... | 159,523 | [
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Effects of plasma and serum on arterial endothelium. | Electron microscopic study of the femoral artery of rats following a single brief intra-arterial infusion of two different types of rat plasma and of rat serum led to the following findings and conclusions: 1. Plasma from heparinised blood caused no endothelial injury whatsoever whereas plasma from citrated blood damag... | 159,542 | [
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[Ultrastructural organization of the inner medullary zone of the kidney of the water vole Arvicola terrestris]. | Papillary component ultrastructure and acid mucopolysaccharide distribution have been investigated in the kidney of the water vole A. terrestris. Structural differences between the descending and ascending parts of the Henle's loop are rather small, cell cytoplasm of these segments being poor in organells. Unusual ultr... | 159,594 | [
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Temperature compensation of sodium transport and ATPase activity in frog skin. | Na+ transport across frog skin, measured as short-circuit current (SCC) shows perfect temperature compensation in frogs acclimated to 6 degrees, 12 degrees, and 23 degrees C as SCC values observed at the acclimation temperatures are equal (about 13 muA/cm2). Reacclimation experiments show that this is not a starvation ... | 159,598 | [
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Left ventricular function at rest and during exercise after aortic valve replacement in patients with aortic regurgitation. | To determine the effect of aortic valve replacement on reversing abnormalities of left ventricular function in patients with aortic regurgitation, radionuclide cineangiography was used to study 16 sympatomatic patients with aortic regurgitation before and 6 months after aortic valve replacement. Before operation, left ... | 159,618 | [
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A study of the effect of pregnancy on muscle fibers of the rectus abdominis muscle of the rat. | Samples of the rectus abdominis muscle were taken from Sprague-Dawley rats at 0, 3, 6, 6, 12, 15, 18, and 21 days of pregnancy, and at 1, 3, 6, 9, 12, and 15 days of postpartum. Sections were incubated for actomyosin adenosine triphosphatase activity following preincubation at a basic pH. Muscle fibers within a unit ar... | 159,648 | [
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The anatomic rationale for abdominal lipectomy. | Changes occur in the vascular and lymphatic flow and in the sensory pattern of the superficial abdominal wall during abdominal lipectomy. The development of these systems, their anatomic descriptions in the abdominal wall, and the changes created by the surgery are documented to explain tissue survival following the pr... | 159,651 | [
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The use of thymoxamine in eyelid retraction. | We observed substantial narrowing in 75% of fissures in patients with various types of lid retraction after topical application of aqueous 0.5% thymoxamine (moxisylyte). Even contralateral normal-appearing fissures in thyroid patients responded in this manner. The nonresponders in the lid retraction group included a pa... | 159,683 | [
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Chitin synthase activity from the slime variant of Neurospora crassa. | Chitin synthase (UDP-2-acetamido-2-deoxy-D-glucose:chitin 4-beta-acetamidodeoxy-D-glucosyltransferase, EC 2.4.1.16) activity from the wall-less variant of Neurospora crassa (slime) was partially characterized. The slime enzyme activity was found to be similar to that reported for slime-like and wild-type chitin synthas... | 159,723 | [
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[Quantitative model of human erythrocyte glycolysis. Region of cell viability determined by ATP concentration]. | The boundaries of the cell vitality domain in the enzyme activity space are calculated on the basis of a mathematical model of erythrocyte glycolysis. The boundaries are determined by key metabolite concentrations. The results obtained are compared with experimental data related to erythrocytic enzymopathies. It is sho... | 159,725 | [
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[Increase of non-specific resistance to infection by synthetic adjuvants]. | MDP and some other synthetic glycopeptides which are endowed with adjuvant properties are also able to increase non-specific resistance of mice to bacterial infections. They are effective by various routes including the oral route, and this protective activity can be demonstrated in animals having a poor immune status. | 159,749 | [
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[Cell mediated cytolysis: identification, enumeration and characterization of killer cells]. | Killer cells responsible of the cell mediated cytolysis are identified by a microtechnique: effector cells are individually associated to target cells and incubated at 37 degrees C; killers are identified by their associated target lysis. Thus killer cells are enumerated in the effector cell suspensions. Furthermore, i... | 159,753 | [
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Ultrastructural and biochemical study of extracellular matrix vesicles in normal alveolar bone of rats. | The occurrence of vesicles in the extracellular matrix of alveolar bone of normal young rats was demonstrated by both ultrastructural and enzymatic studies. Transmission electron microscopy revealed abundant vesicles in the matrix. The presence of hydroxyapatite crystals, both within the vesicles and in the matrix, was... | 159,774 | [
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Characterization of mouse ribosomal gene fragments purified by molecular cloning. | Four mouse ribosomal gene fragments cloned in lambda gtWES were studied by restriction enzyme mapping and Southern transfer experiments. These fragments were found to contain 18S DNA and transcribed as well as non-transcribed spacer DNA. Variation in the structure of these mouse DNA inserts was limited to one region of... | 159,852 | [
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[The concept of social pediatric assistance in the development of handicapped children. Possibilities, problems and future measures]. | Principles and possibilities of the social pediatric concept (Hellbrügge) in treatment and aids for handicapped children are demonstrated. Beside positive experiences there are still some unsolved problems: control of therapeutic efficiency, increasing amount of psychic and social handicaps, lack of psychotherapeutic p... | 159,857 | [
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Pseudocholinesterase activity and E1 phenotypes in Down's syndrome and mental retardation. | Pseudocholinesterase activity and the phenotypes controlled by the E1 locus have been determined in a sample of 307 Down's syndrome patients and 206 patients suffering from nonspecific mental retardation and compared to those in the healthy population. Both groups of patients have an elevated frequency of phenotypes po... | 159,860 | [
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Topical fluorouracil therapy for precancers and cancers of the skin. | Topical fluorouracil (FU) is an extremely effective agent for treating multiple actinic keratoses. It is also of value in the treatment of Bowen's disease, actinic cheilitis, arsenical keratoses, radiodermatitis, X-ray-induced keratoses, leukoplakia, and the erythroplasia of Queyrat. Topical FU may be successful in the... | 159,921 | [
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The receptor specificity of alloreactive T cells. Distinction between stimulator K, I, and D region products and degeneracy of third-party H-2 recognition by low-affinity T cells. | The specificity of binding of stimulator-derived H-2 antigens by mixed lymphocyte culture (MLC)-activated T blasts was investigated under conditions of antigen excess. We have shown that the detectable proportion of alloantigen-binding blasts from primary MLC is a function of antigen concentration, and can represent up... | 159,939 | [
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0.1743295,
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-0.1763773,
0.06831546,
0.1946865,
0.8553888,
0.3101293,
-0.1501814,
0.... |
Effects of endurance training on muscle fibre ATP-ase activity, capillary supply and mitochondrial content in man. | Seven young females were subjected to 24 weeks of intensive endurance training. Adaptive changes in myofibrillary ATP-ase activity, capillary supply and mitochondrial content were investigated with light- and electron microscopy in needle biopsies from the quadriceps femoris. 1. The average value for the maximal oxygen... | 159,945 | [
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0.00549687,
0.0553... |
On the regional histology and histochemistry of the epididymis of the camel (Camelus dromedarius). | Distinct morphological regions, initial, middle and terminal segments, were distinguishable histologically; the middle segment was further subdivided into proximal, intermediated and distal parts. PAS-positive, diastase-resistant reaction was detected in the blood vessels, subepithelial tissue and stereocilia of all se... | 159,947 | [
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[Classification of acquired aortic stenosis (based on electrocardiographic study data)]. | The article is based on the case records of 192 patients with acquired aortic stenosis and interpretation of the ECG of 187 patients. In this group, 143 patients underwent operation and 8 died in the period of their examination. The purpose of the examination consisted in determining whether or not the ECG could charac... | 159,969 | [
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0.1487747,
-0.1874659... |
[X-ray angiocardiographic characteristics of the heart in arterial hypertension]. | Correlation-statistical analysis of the roentgenocardiometric indices and the findings of left ventriculography in 30 patients with arterial hypertension was conducted. A significant inter-relationship of the roentgenometrical criteria of enlargement of the heart (cardiothoracic index, the extent of convexity of the ar... | 159,974 | [
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0.08209632,
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Phosphorprotein intermediate in the Ca2+-dependent ATPase reaction of macrophage plasma membrane. | ATPase activity and phosphorylation by [gamma-32P] ATP of isolated plasma membrane of alveolar macorphages are stimulated in a parallel fashion by physiologic concentrations of Ca2+, with half-maximal activating effect of this ion at (3--7) X 10(-7) M. For various membrane preparations, a direct proportionality exists ... | 159,982 | [
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0.1283045,
0.3... |
[Participation of Mg2+ and Ca2+ ions and the corresponding ATPases in the mechanism of the presynaptic action of amisyl and arecoline]. | Amisyle and arecoline were found to be antagonistic drugs in the effect on content of Mg2+ and Ca2+ and on activity of corresponding ATPases in synaptosomes isolated from rat brain. Amisyle promoted the incorporation of 45Ca into synaptosomes but arecoline inhibited the reaction. The appear to be responsible for libera... | 160,132 | [
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... |
[Clinical experience with levamisole treatment of patients with systemic lupus erythematosus (author's transl)]. | Levamisole treatment was started in 8 patients with inactive SLE. Four patients, who have now been followed up for over 12 months, have not shown clinical deterioration. Three of these patients received concomitant maintenance corticosteroid therapy, the dosage of which could be reduced in each case. A decrease in anti... | 160,142 | [
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0.6156607,
0.2599282,
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[Comparson of occlusal conditions in juveniles from residential areas with different drinking water fluoride contents (author's transl)]. | The investigations reported in this paper were conducted in Karl-Marx-Stadt after 16 years from the introduction of drinking water fluoridation (1.0 ppm F), with a total of 792 randomly selected juveniles (whose average age was 14.9 years) being examined. Serving as a control group were 780 juveniles of the same age (1... | 160,157 | [
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0.1... |
[Autoradiographic determinations of carbon-14-labeled monomers and residual monomers in the tissues of Wistar rats after implantation of cold-polymerizing polymethyl methacrylate (bone cement) (author's transl)]. | Self-setting acrylics, named bone cement, are taken for the reconstruction of bone defects, for the fixation of endothesis and fractures. A disadvantage of these rapid-cure acrylic compounds is the toxicity of its monomer. Infraredspectrographic measurements showed an absolute content of 12,3 per cent monomer in an acr... | 160,161 | [
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0.508938,
0.4155895,
0.3975436,
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0.... |
[Phage typing and lysogen typing of Staphylococcus aureus]. | A comparison was made between the results of phage and lysogenic typing of S. aureus strains isolated during several outbreaks of staphylococcal infection and S. aureus cultures isolated from the same carriers at different periods. The study of the groups of strains having the same origin showed that the differences in... | 160,170 | [
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Pretibial myxoedema: stimulation of mucopolysaccharide production of fibroblasts by serum. | We have shown that sera from normal individuals and from patients with pretibial myxoedema contain a factor which simulates mucopolysaccharide biosynthesis in normal human skin fibroblasts cultured in vitro. This factor was present in larger amounts in sera of patients with pretibial myxoedema. The role of growth stimu... | 160,243 | [
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The early diagnosis of ectopic pregnancy. | In a survey of 235 consecutive cases of ectopic pregnancy it was found that over 50 per cent were incorrectly diagnosed by the general practitioner and 36 per cent by a hospital doctor. Ten per cent of patients were sent home before the diagnosis was made. Over 30 per cent of patients were sent to general surgical ward... | 160,264 | [
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0.373... |
[Attempt at modification of the pharmacological and toxic effects of cocaine]. | The increase in locomotor activity induced by cocaine (15 mg/kg, i.p.) in the mouse was antagonized by pretreatment with compounds which inhibited monoanimergic receptors such as phenoxybenzamine, chlorpromazine or methysergide. On the contrary, the lethal dose of cocaine in rats and mice was not reduced by these subst... | 160,275 | [
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Specificity of the bacteriophage lambda N gene product (pN): nut sequences are necessary and sufficient for antitermination by pN. | We have cloned the nutR site together with the tR1 site of bacteriophage lambda in the E. coli galactose operon to examine whether the lambda promoter sequences PR and PL are involved in the recognition specificity of the lambda N gene product (pN). We first constructed a derivative of plasmid pBR322 in which the expre... | 160,286 | [
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Subcellular calcium localization and AT0-dependent Ca2+-uptake by smooth endoplasmic reticulum in an invertebrate photoreceptor cell. An ultrastrucutral, cytochemical and X-ray microanalytical study. | In Hirudo medicinalis an extensive and highly elaborate three dimensional network of smooth endoplasmic reticulum cisternae is found in very close structural relationship to the receptive (microvillar) membrane, as reported for many other invertebrates. A variant of the potassium pyroantimonate technique showed that th... | 160,317 | [
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Inhibition of E coli ATPase activity by a troponin component, TN-I, and by mitochondrial ATPase inhibitor. | The enzymic activity of Mg2+- or Ca2+-stimulated ATPase from Escherichia coli was inhibited by one of the troponin components, TN-I, and by mitochondrial ATPase inhibitor (F1-inhibitor). The inhibitory ability of component TN-I against Mg2+-stimulated AtPase activity was lost after digestion of component TN-I with tryp... | 160,325 | [
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A rightward promoter to the left of the att site of lambda phage DNA: possible participant in site-specific recombination. | The binding has been studied of Escherichia coli RNA-polymerase to the fragments of lambda DNA obtained by digestion with restriction endonucleases BsuI, HindIII, BamHI, EcoRI and HindII + III. There are at least six sites of RNA-polymerase binding in the b2-region. In vitro transcription of those BsuI-fragments of the... | 160,359 | [
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The organization of a nuclear DNA sequence from a higher plant: molecular cloning and characterization of soybean ribosomal DNA. | The recombinant DNA vector, lambda Charon 4A, was used to construct a library of DNA sequences from the genomic DNA of soybean (Glycine max). To define the organization of ribosomal DNA (rDNA) in the soybean genome, clones containing sequences complementary to both 17S and 25S rRNA have been isolated from this library ... | 160,361 | [
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[Computer tomography in the diagnosis of local recurrences after resection for carcinoma of the rectum (author's transl)]. | Presacral or pelvic floor tumour recurrence after abdomino-perineal resection for rectal or anal carcinomas has not been amenable to early radiological diagnosis. Computer tomography is a procedure which can demonstrate recurrences of two to three cm. Within the pelvis with certainty. The reliability of the method has ... | 160,376 | [
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Dengue virus-induced thymus-derived suppressor cells in the spleen of mice. | Adoptive transfer of spleen cells obtained from mice given three weekly i.p. doses of dengue type 2 virus (DV) suppressed DV antigen-specific antibody secretion as detected by the Jerne plaque technique. This suppression was produced by non-glass-adherent cells but not by glass-adherent cells. Immune spleen cells deple... | 160,396 | [
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Interactions between central monoaminergic systems: dopamine-serotonin. | Concentration of dopamine and serotonin metabolites (HVA and 5-HIAA) in the CSF was evaluated before and after pharmacological treatment in 19 patients with different neuropsychiatric diseases. In every case a reciprocal modification of the two metabolites occurred after treatment. The result supports the hypothesis of... | 160,445 | [
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0.135777,
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Association of myocardial cell necrosis with experimental cardiac hypertrophy. | Cardiac hypertrophy was induced in rabbits by injecting thyroxine or isoprenaline, or by surgically constricting the abdominal aorta. An increase in heart weight was associated with a change in the ratios of bound to free forms of five lysosomal enzymes, a change in serum creatine phosphokinase and lactate dehydrogenas... | 160,447 | [
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Effect of endurance training on myocardial myosin adenosine triphosphatase activity of the dog. | Endurance exercise training has been found to enhance the functional capacity of the myocardium in several animal models. The sub-cellular phenomena accompanying the augmented function are yet to be explained. The present study sought to determine if the myosin ATPase activity of cardiac muscle increased as a result of... | 160,487 | [
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0.1812321,
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Extrusion of peritoneal catheter through abdominal incision: report of a rare complication of ventriculoperitoneal shunt. | A rare complication of a ventriculoperitoneal shunt is reported. The peritoneal catheter extruded through the well-healed abdominal incision. This is the first report of such an occurrence in an adult patient. | 160,511 | [
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Evaluation of electrode array material for neural prostheses. | Matrix support materials for brain surface electrodes used in neuroprosthetic applications were evaluated after chronic subdural implantation over the parietal cortex of the cat. Four types of array fabricated with Silastic, Dacron mesh, or platinum wire annuli were implanted for periods ranging from 5 weeks to 1 year.... | 160,513 | [
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0.240577,... |
Instantaneous measurement of glomerular filtration rate in the isolated perfused rat kidney. | In perfusion studies on the isolated cellfree perfused rat kidney, the glomerular filtration rate (GFR) can be controlled if the GFR can be measured instantaneously. This paper reports on a GFR meter which opens this possibility. Vitamin B12 is used as a marker for the GFR. A bubble flow meter determines urine flow rat... | 160,537 | [
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0.5511646,
0.130673,
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... |
Cleavage of single-stranded DNA by the A and A* proteins of bacteriophage phi X174. | The purified A protein and A* protein of bacteriophage phi X174 have been tested for endonuclease activity on single stranded viral phi X174 DNA. The A protein (55.000 daltons) nicks single-stranded DNA in the same way and at the same place as it does superhelical RFI DNA, at the origin of DNA replication. The A* prote... | 160,544 | [
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-0.2988592,
... |
Size fractionation of DNA fragments by liquid-liquid chromatography. | A method for the fractionation of double-stranded DNA fragments from 150 to 22000 b.p. in size by liquid-liquid chromatography is described. The procedure makes use of the fact that the partitioning of DNA in a polyethylene glycol-dextran system is size dependent and can be altered by alkali metal cations. Cellulose or... | 160,546 | [
-0.08428904,
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0.2000366,
0.1767353,
0.475082,
0.01596835,
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Role of thymidylate synthetase activity in development of methotrexate cytotoxicity. | Methotrexate (MTX) inhibition of the growth of mouse or human leukemia cells in culture was partially prevented by either thymidine (dThd) or hypoxanthine. 5-Fluoro-2'-deoxyuridine (FdUrd) also decreased the growth-inhibitory potency of MTX in the presence of small concentrations of 5-formyltetrahydrofolate (citrovorum... | 160,558 | [
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0.4893134,
0.2095651,
0.2953087,
-0.2402364,... |
Identification of the lexA gene product of Escherichia coli K-12. | The Escherichia coli lexA gene encodes a product important in induction of the recA gene and the expression of various cellular functions, including mutagenesis and prophage induction. As a start in a biochemical analysis of the lexA function, a family of lambda transducing phages carrying lexA+, lexA3, lexA3 spr-54, a... | 160,562 | [
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0.301598,
0.01430901,
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0.2596... |
Effect of flavonoids on vitamin C activity of D-isoascorbic acid. | Large peroral doses of D-isoascorbic acid, a vitamin C stereoisomer (50 mg per animal per day), were retained in the guinea-pig organism to a smaller extent than the same doses of L-ascorbic acid (vitamin C). Simultaneous administration of the flavonoids rutin and epicatechin increased the amount of D-isoascorbic acid ... | 160,573 | [
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0.411572,
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... |
Effects of PGI2 on the inactivation of thrombin, factor Xa, and plasmin by antithrombin-III and heparin. | The influence of PGI2 on the activity and on the inactivation of enzymes participating in blood coagulation (thrombin and Factor Xa) and fibrinolysis (plasmin) were investigated. According to the results PGI2 has no effect on the activity of Factor Xa and plasmin nor on the inactivation of these enzymes by antithrombin... | 160,589 | [
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0.4686307,
0.6107326,
0.2778586,
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... |
Studies of anti-lymphocyte antibody of patients with active SLE. I. Cause of loss of suppressor T-lymphocyte function. | Effect of anti-lymphocyte antibody of active systemic lupus erythematosus (SLE) on lymphocyte function was examined. Lymphocytes from normal individuals treated with anti-lymphocyte antibody and complement exhibited marked inhibition of response to concanavalin A (Con A), while the response of lymphocytes to phytohaema... | 160,612 | [
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0.4685669,
0.1821259,
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-0.0... |
Human T-lymphocyte subpopulations: alterations in systemic lupus erythematosus. | Sharply reduced proportions of T cells with Fc receptors for IgG (TG cells) were observed in blood samples from patients with systemic lupus erythematosus (SLE), mainly with active disease. This T-cell subset has previously been shown to be a suppressor in the pokeweed mitogen (PWM)-dependent B-cell differentiation. In... | 160,613 | [
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0.5675047,
0.3119088,
0.1710019,
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... |
Fatal eosinophilic gastroenterocolitis in a two-year-old child. | We report a case of eosinophilic gastroenterocolitis in a 2-year-old child with extensive fibrosis, atrophy of the muscularis propria and involvement of stomach, small bowel and colon. Following an attack of acute gastroenteritis at the age of 15 months the symptoms of ileus persisted. A biopsy of small bowel at the ag... | 160,665 | [
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0.02478308,
0.3362232,
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... |
Factors affecting the histochemical composition of reinnervated soleus muscle of rat. | The myofibrillar ATPase reaction was utilized to determine the relative proportion of type II fibres in reinnervated soleus muscle 6 months after transection and reunion of the nerve at various distances from the muscle. In self-reinnervated soleus muscle, a highly significant decrease in the percentage of type II fibr... | 160,738 | [
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0.1077012,
0.2709257,
0.2126731,
0.04947609,
... |
Morphological, histochemical and X-ray microanalytical examination of deposits on soft contact lenses in extended wearing. | The deposits on 29 contact lenses of various water content from 20 wearers were analysed by the methods given in the title. Six lenses were used as bandage lenses, the remaining for optical correction. The age of the patients varied from 7 to 56 years, two-thirds being under 45 years. Wearing time had been from 1 week ... | 160,743 | [
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0.480073,
0.04642044,
0.0... |
Effect of pyrantel tartrate and carbadox on acquisition of the swine kidneyworm (Stephanurus dentatus) and other parasites by pigs on contaminated lots. | A combination of pyrantel tartrate (106 mg/kg of body weight) and carbadox (55 mg/kg of body weight) in ground feed was fed to 20 weaned pigs (av wt, 14.4 kg) for 42 days. Another group of 20 pigs included nontreated controls. The pigs were farrowed and suckled in a slat-floored farrowing house and had minimal exposure... | 160,763 | [
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0.4492055,
0.3276142,
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0.4231726,
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Identification and distribution of swine serum immunoglobins that react with Trichinella spiralis antigens and may interfere with the enzyme-labeled antibody test for trichinosis. | Sera from Trichinella spiralis digestion-negative swine contained variable amounts of two immunoglobins that reacted with T spiralis antigen in the indirect enzyme-labeled antibody test for trichinosis. One of these immunoglobins, detected by heavy chain-specific anti-swine immunoglobulin G (IgG) conjugate, was removed... | 160,765 | [
0.00007652443,
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0.0584889,
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0.268259,
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[Excito-motor action of succinyldicholine and inhibitory action of acetylcholine on slow muscle, the frog hypoglossus]. | We have registered contraction of the frog's hyoglossus which is essentially slow. By injecting succinyldicholin in the heart ventricle, we have elicited contractions which prove definitively the motor effect of this cholin ester on the slow muscular fibers. Acetylcholin, injected in the lymph vessels to avoid its effe... | 160,812 | [
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0.3794296,
0.164967,
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0.2265342,
... |
[Cutaneous and subcutaneous blood flow measurement in rabbit's ear by epicutaneous diffusion of xenon 133. Influence of the arteriovenous anastomosis]. | The cutaneous and subcutaneous blood flow measurement by a diffusible inert gas concerns theorically capillary nutritional flow. In clinical routine, where pathological openning of arteriovenous anastomosis is suspected, the blood flows measured by Xenon technic are often increased. The function of the shunts are displ... | 160,819 | [
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0.1210984,
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0.2468605,
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0.2743477,
0.04667322,
0.0603625... |
[Evaluation of cell regeneration of bone marrow after fractional irradiation of the mouse in toto]. | We have studied the recovery for mice bone marrow cells after fractionated irradiation of the whole body. The additional dose (Dr) to obtain a given biological effect if the irradiation is split in two equal subfractions (2 Di) separated by a short interval of time (i) is 40 rad per day when the interval of time betwee... | 160,828 | [
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0.1161018,
-0.1176862,
0.4634397,
0.3834623,
0.03139922,
-0.011... |
Functional studies on T cells in adult human bone marrow. | Bone marrow (BM) lymphocytes were obtained by sucrose density gradient centrifugation of the nucleated cells from adult human BM. BM was obtained from rib sections removed routinely during thoracotomy from thirteen patients with a localized lung tumour and from two other patients without tumour (mean age 47 years). The... | 160,850 | [
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0.03548024,
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0.2195113,
0.5849752,
0.6199501,
0.1784733,
0.05330767... |
Nickel, cobalt and chromium sensitivity in patients with pompholyx (dyshidrotic eczema). | Sixteen patients with negative routine patch tests were challenged orally in a controlled trial with 2.5 mg nickel, 1 mg cobalt, and 2.5 mg chromium given as salts of the respective metals. All of the patients had symmetrical, vesicular hand dermatitis and in some cases also foot involvement. The dermatitis of two pati... | 160,856 | [
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-0.3027734,
-0.0005594322,
0.42729,
0.0281... |
Down syndrome: prevalence at birth, mortality and survival. A 17-year study. | Analysis of comprehensive records over a period of 15 yr permits calculation of the total prevalence of Down Syndrome in an industrial city. The prevalence at birth is shown to have fallen from 1.70 per 1000 births in the period 1961--65 to 0.84 per 1000 births in 1971--75. The fall in prevalence can be shown to be lar... | 160,868 | [
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0.3139885,
0.1257003,
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0.3627667,
0.653776,
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-0... |
Quantitative immunoelectrophoretic analysis of Streptococcus pyogenes membrane. | The antigenic composition and molecular structure of the plasma membrane of Streptococcus pyogenes (group A; M type 6) were studied by crossed immunoelectrophoresis (XIE) and other related quantitative immunoelectrophoretic techniques. After establishment of a reference pattern of 29 immunoprecipitates, the relative di... | 160,891 | [
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0.001544551,
0.9224517,
0.2959294,
-0.2832865... |
Effect of experimental magnetic storm on the production of lambda phage. | 1. Sharp fluctuation of the intensity of the vertical component of the MF amounting to +/- 0.1 Oe changing the sign over each 3 min causes variability of both lysogenic and indicator strains of E. coli. This testifies to an extremely low threshold of their magnetic susceptibility and to biological importance of fluctua... | 160,920 | [
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0.1123714,
0.3236178,
0.2477289,
-0.137379... |
Avoidance of the handicapped: an attributional ambiguity analysis. | We demonstrated a general strategy for detecting motives that people wish to conceal. The strategy consists of having people choose between two alternatives, one of which happens to satisfy the motive. By counterbalancing which one does so, it is possible to distill the motive by examining the pattern of choices that p... | 160,924 | [
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0.1683783,
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0.03183508,
0.06522627,
0.3443715,
0.02438266,
... |
Immunologic aspects of renal lesions associated with malaria. | Studies on experimental models of infections and observations in man indicate that immune complexes (IC) play an important role in the pathogenesis of nephropathies associated with malaria. All present evidence suggests that IC preformed in circulation localize in the glomeruli and initiate the lesions. In acute lesion... | 160,963 | [
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0.1688492,
0.1504794,
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[Distribution of dracunculiasis in Mali. A survey of the Cyclops habitat (author's transl)]. | The authors report the distribution and the incidence of dracunculiasis in the seven administrative regions of Mali. They describe the various types of Cyclops habitat and the seasonal variations in transmission. They discuss the resulting effects of dryness and rural water development on this endemic parasitic disease... | 160,970 | [
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0.5231928,
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0.3385908,
0.42961,
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0.... |
Light microscopic observations on fibrous plaque histogenesis in the coronary arteries of children. | An attempt was made to reconstruct the succession of structural changes which lead to the onset of fibrous plaques in the coronary arteries of children. The results show that certain branch pads or cushions act as precursors of the first fibrous plaques. The conversion of branch pads into atherosclerotic lesions includ... | 160,988 | [
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0.3566826,
0.3126483,
0.2441011,
-0.2572924,
0.0... |
Barbiturates and calcium-activated adenosine triphosphatase. | Anaesthetic barbiturates potentiate and convulsant barbiturates inhibit the calcium-activated adenosine triphosphatase (Ca-ATPase) activity in rat brain synaptosomes. Such differential effects and consequent modification of transmitter release may be important in the contrasting actions of these classes of barbiturates... | 161,001 | [
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0.05550421,
0.1986536,
0.2241538,
-0.02676916,
-0.01084029,
... |
The measurement of cerebrospinal fluid flow. | A technique for the measurement of cerebrospinal fluid (CSF) velocity-flow is described. It enables the flow of CSF in response to pressure pulses to be measured whilst allowing the simultaneous measurement of pressure through a lumber puncture needle. The physical principles which govern the operation of the flow prob... | 161,026 | [
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0.00253088,
0.2251957,
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0.167... |
[The prediction of growth in long bones in poliomyelitis (author's transl)]. | The authors have studied 15 cases of unilateral poliomyelitis and have compared the growth of the intact lower limb with that of the paralysed limb. It is concluded that no accurate prediction can be made except by multiple measurements. In most of the cases, growth was steady, the rate of shortening increasing by regu... | 161,041 | [
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0.3964999,
0.4052982,
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-0.1710278,
... |
Lack of suppressor cell activity in rheumatoid synovial lymphocytes. | Lymphocytes were eluted from the synovial tissue of seventeen patients with rheumatoid arthritis (RA) and one with ankylosing spondylitis. In eight of these patients immunoglobulin production by synovial lymphocytes in the presence and absence of pokeweed mitogen was studied. In nine patients T lymphocytes were isolate... | 161,065 | [
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0.2050729,
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-0.2237911,
-0.09976768,
0.1082354,
0.04705643,
-0.02101975,
0.0002982522,
0.05885036,
-0.3335434,
-0.04028681,
-0.01496505,
0.4277897,
0.3864628,
0.3094208,
0.0... |
[Effect of 2 phosphonates on the osteolysis induced by tumor extracts]. | An in-vitro model is proposed to test the potential effect of diphosphonates in treatment or preventing bone metastases. This model involves culturing of neonatal mice calvaria in sterile conditions in an appropriate medium and measuring 45Ca release from bone to medium, the mice being injected with 45Ca on the day of ... | 161,073 | [
-0.3888149,
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0.1145643,
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0.6209882,
0.4598835,
0.03469089,
-0.1983327... |
[Histophysiological characterisation of chorion. Histological, histochemical, and electron-microscopic investigations (author's transl)]. | Histological, histochemical, and electron-microscopic techniques were used to investigate the chorion in 15 women over the first four to eight weeks of normal pregnancy. Evidence was produced to maximum enzyme activity and lipoid accumulation between the sixth and eighth weeks. These findings were confirmed by ultrastr... | 161,129 | [
0.0897399,
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0.3850078,
0.4941704,
0.4768336,
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... |
A comparative study of DNA-induced transformants and spontaneous revertants of inositolless Neurospora crassa. | Inositolless (inl-) Neurospora crassa strains were treated with DNA (allo-DNA) of wild type N. Crassa. Hyphal fragments of a mycelial suspension of the N. Crassa ragged inl- strain used as recipient in our transformation experiments were found to consist of units containing 100--1000 nuclei. In this strain the inositol... | 161,130 | [
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0.2926803,
0.4326727,
-0.0774041,... |
[Neuromuscular block control during and after anaesthesia (author's transl)]. | During many years the clinician's requirements for neuromuscular blocking drugs are satisfied by clinical investigations. Electromyographic recordings which are a satisfactory method are not useful in current practice. The use of nerve stimulators as Churchill Davidson apparatus modified for train of four impulses must... | 161,146 | [
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0.05836337,
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0.09961589,
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0.02829837,
0.4698947,
-0.01467683,
0.04052543... |
Determination of cardiac output of the artificial heart from the drive air flow. | An indication chamber, inserted between the right heart drive and the pump proper, was designed to provide continual measurement of the quantity of blood pumped by the pneumatic artificial heart. The flow is evaluated from the motion of a piston provided with a photoelectric transducer. The effect of compressibility of... | 161,167 | [
-0.190766,
0.3355958,
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0.172921,
-0.1508024,
0.1545748... |
[Bactericidal effects of macrophages of mice treated with interferon]. | The preparations of interferon or virus-inhibiting factor produced in L cell (L-IF) and mouse brain (MB-IF) enhanced the killing of Staphylococcus aureus (S.a.) by the mouse peritoneal macrophage. The L-IF, heat-inactivated at 80 degrees or 60 degrees for 30 min., and mock L-IF could not enhance the killing of S.a. The... | 161,179 | [
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0.005969388,
0.7079586,
0.07320245,
-0.2356808,
-0.2448047,
... |
[Effects of microwaves on the cellular immune response of Swiss mice]. | Biological effects of microwaves (2450 MHz) were studied on cellular immune response of Swiss mouse. The obtained results show an increase of MIF, PFC and Phagocytosis values after microwaves irradiation. | 161,189 | [
-0.2028411,
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0.4385333,
0.09434381,
-0.05287516,
0.06... |
[Effect of vinblastine on the blast population of the thymus subcapsular zone in the mouse]. | It is well admitted that blast cells of the thymic subcapsular zone play an important role in murine leukemogenesis. Previous ultrastructural investigations have revealed the morphological heterogeneity of this population which is formed by lymphoblasts, X cells and ring shaped nucleolus cells. These aspects could corr... | 161,192 | [
0.01644347,
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0.2802442,
0.3589991,
0.7574191,
-0.009481185,
0.00035195... |
[Effect of oligopeptides containing L-Phe, L-Tyr, L-Trp, L-His or L-Met on the excitability of the 2 giant neurons of the African giant snail (Achatina fulica Ferussac)]. | Effects of about ninety oligopeptides, containing L-Phe, L-Tyr, L-Trp, L-His and L-Met, on the excitability of two identifiable giant neurones (the PON, periodically oscillating neurone ; and the TAN, tonically autoactive neurone) of Achatine fulica Férussac were examined. Three oligopeptides, L-Lys-L-Phe-L-Tyr, L-Phe-... | 161,198 | [
0.0509607,
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0.003277562,
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0.1857502,
0.1491178,
0.147885,
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0.1581272,
-0.2028281... |
A simple technique for the isolation of deletion mutants of phage lambda. | We describe a simple technique for isolating deletion mutants of phage lambda and use it to dissect a cloned fragment of foreign DNA. The technique is based on our previous finding that the normally essential product of lambda head gene D is dispensible for phage growth if the DNA content of the phage is less than 82% ... | 161,244 | [
-0.03768785,
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0.314971,
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0.007148658,
0.5310656,
0.547085,
0.01990236,
-0.2289786,
0.0655... |
Doming of the pulmonary valve after valvotomy. | Doming of the pulmonary valve is considered an important angiographic sign for valvar stenosis. But, this sign cannot be used with similar specificity following valvotomy because at the time of surgery a bicuspid valve is created. Pre- and postoperative hemodynamic data and right ventriculograms are reviewed in 22 pati... | 161,260 | [
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0.04715361,
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0.1496844,
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0.4342498,
0.1938441,
-0.121502,
0.1818134,
0.2665808,
-0.1020891,
... |
PCPA potentiates the effects of specific copulatory experience on the sexual behavior of the pudendectomized male rat. | The interactional effects of bilateral pudendectomy and sexual experience were studied on the sexual behavior of male rats. In Experiment 1, limited sexual experience in terms of mounts, intromissions or ejaculations was provided prior to the operation. The sexual behavior was then tested before and after treatment wit... | 161,401 | [
0.05865081,
0.133337,
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0.1877971,
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0.05744794,
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0.1439179,
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0.1152901,
0.06843377,
0.1600394,
0.1527601,... |
Immunological release of histamine from human lung. II. Studies on acetylcholine and the anticholinergic agent ipratropium bromide. | The experiments reported in this work have been performed to measure the effects of acetylcholine and the anticholinergic agent ipratropium bromide on the antigen-induced release of histamine from sensitized human lung in vitro. Primarily, ipratropium bromide did not have any effect, even at higher concentrations. Acet... | 161,410 | [
0.09921951,
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-0.2885074,
-0.2226705,
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0.1938273,
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0.1000996,
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0.03975294,
0.0130136,
0.07647117,
0.01574323,
... |
A new fluorogenic substrate for plasmin. | A new fluorogenic peptide substrate for plasmin, 7-(N-succinoylalanylphenylalanyl-lysylamido)-4-methylcoumarin trifluoroacetate salt, was prepared that can be used in a simple and direct assay. The results obtained by the assay method are linear over a wide range of enzyme concentrations and sensitive enough to detect ... | 161,507 | [
0.1111945,
-0.06669886,
-0.3942097,
-0.1960935,
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0.04332738,
0.2488649,
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0.250294,
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0.4796121,
0.3847273,
-0.1245802,
-0.07786889,... |
Structure of heparan sulphate oligosaccharides and their degradation by exo-enzymes. | Oligosaccharides obtained from heparan sulphate by nitrous acid degradation were shown to be degraded sequentially by beta-D-glucuronidase or alpha-L-iduronidase followed by alpha D-N-acetylglucosaminidase. Structural analysis of the tetrasaccharide fraction showed the following. (1) N-Acetylglucosamine is preceded by ... | 161,508 | [
-0.1412888,
0.1754368,
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0.3633857,
0.1630316,
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0.2253209,
0.3159608,
-0.1504282,
0.3723912,
0.2163689,
-0.1018644,
-0... |
Guinea worm disease: epidemiology, control, and treatment. | Guinea worm infection is one of the most easily prevented parasitic diseases, but it is nevertheless a common cause of disability in rural areas of Africa, south-west Asia, and India. Infection occurs when drinking water is infested with infected Cyclops, a microcrustacean. Worms up to 70-80 cm in length develop in the... | 161,522 | [
-0.1545894,
0.04853331,
0.3427553,
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0.02237083,
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0.06873064,
0.07663569,
0.122447,
0.08967703,
0.538476,
-0.4006165,
... |
Complementation analysis of eleven tryptophanase mutations in Escherichia coli. | Nine independent mutants deficient in tryptophanase activity were isolated. Each mutation was transferred to a specialized transducing phage that carries the tryptophanase region of the Escherichia coli chromosome. The nine phages thus produced, and a tenth carrying a previously characterized tryptophanase mutation, we... | 161,572 | [
-0.06961253,
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-0.250319,
-0.02832396,
-0.03810159,
-0.1035045,
0.0418937,
0.2656579,
-0.0983276... |
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