title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Pathogenesis of of cytomegalovirus infection. I. Activation of virus from bone marrow-derived lymphocytes by in vitro allogenic reaction. | After infection in utero or at birth with a cell culture adapted strain of mouse cytomegalovirus (MCMV), several mouse strains developed a latent virus infection in the presence of specific antiviral antibodies. Up to 5 mo after infection, MCMV could be activated and recovered from spleen lymphocytes of the infected an... | 163,887 | [
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A dual synaptic effect on hair cells in Hermissenda. | Type A photorecptors can produce an initial hyperpolarizing wave followed by a delayed long-lasting increase in firing which is usually accompanied by a small depolarizing wave. The initial hyperpolarizing wave arises from an increase in conductance while the depolarizing wave was shown to arise from a decrease in cond... | 163,891 | [
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Differentiation of Entamoeba: a new medium and optimal conditions for axenic encystation of E. invadens. | Nutritional and culturing requirements for efficient axenic encystation of Entamoeba invadens have been studied. A simple and reliable axenic encystation medium has been developed. It contains 0.5% tryptic digest of casein, 0.5% yeast extract, and 5% dialyzed serum in 5 mM potassium phosphate, pH 7.0. Mass encystation ... | 163,898 | [
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RNA synthesis in cells infected with herpes simplex virus. X. Properties of viral symmetric transcripts and of double-stranded RNA prepared from them. | HEp-2 cells infected with herpes simplex 1 virus contain RNA transcripts capable of forming double-stranded (DS) RNA on annealing. The properties of purified DS RNA were as follows (i) DS RNA is resistant to depolymerization by RNase A or T-1 in 2 times 0.15 M NaCl, plus 0.015 M sodium citrate (SSC) but not 0.1 times S... | 163,916 | [
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In vitro polyoma DNA synthesis: inhibition by 1-beta-d-arabinofuranosyl CTP. | The effects of 1-beta-D-arabinofuranosyl CTP (ara-CTP) on DNA replication were studied in an in vitro system from polyoma-infected BALB/3T3 cells. Ara-CTP concentrations of larger than or equal to 150 muM were found to block in vitro DNA synthesis completely, and concentrations of smaller than or equal to 0.3 muM had ... | 163,918 | [
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Temperature-sensitive host range mutants of herpes simplex virus type 2. | Herpesviruses are capable of several types of infection of a host cell. To investigate the early events which ultimately determine the nature of the virus-host cell interaction, a system was established utilizing temperature-sensitive mutants of herpes simplex virus type 2. Four mutants have been isolated which fail to... | 163,920 | [
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Hyperlipidemia in cerebrovascular diseases. | 1. Hypertriglyceridemia and hyper beta-lipoproteinemia are closely related to the pathophysiologic status of the cerebrovascular patients. 2. The electrophoretic analysis of serum lipoprotein is the usefull method for the study on hyperlipidemia in the cerebrovascular disease. 3. The electrophoretic analysis of the ser... | 163,933 | [
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[Globular corpuscles in hepatomas of Swiss mice]. | In hapatomas formed spontaneously without cirrhosis at Swiss mice numerous globular corpuscules of eosinophil character were found. These corpuscules as revealed by electron microscopy are formed in cyternas of the rough surfaced endoplasmatic reticulum and are of the nature of protein. | 163,957 | [
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The effect of diuretics on Na+-K+-ATPase and c-AMP levels in toad bladder epithelial cells. | Na+-K+-ATPase was inhibited by 1 times 10-4M ethacrynic acid and mercuderamide, and by 1 times 10-3M hydrochlorothiazide and furosemide. A modification of Gilman's (1970) protein displacement assay has been used to measure c-AMP levels in toad bladder epithelial cells. Vasopressin (50 mU/ml) caused c-AMP levels to ri... | 163,990 | [
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Cytomegalovirus endometritis: report of a case associated with spontaneous abortion. | Maternal cytomegalovirus infection is a relatively common, yet very often silent complication of pregnancy. The association between early gestational wastage and cytomegalovirus endometritis has been documented in recent tissue culture studies without the morphologic demonstration of the virus. This case study presents... | 163,996 | [
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The antagonistic effect of an inhalation anesthetic and high pressure on the phase diagram of mixed dipalmitoyl-dimyristoylphosphatidylcholine bilayers. | Several workers have shown that phase transition-related changes in membrane lipids have a profound effect on membrane-solvated protein function. This phase transition temperature dependence has been explained as resulting from the formation of lateral phase separations within the membrane bilayer. The present study de... | 164,016 | [
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Competent Bacillus subtilis cultures synthesize a denatured DNA binding activity. | A protein activity has been detected in soluble extracts of competent cultures of bacillus subtilis which protects denatured DNA from nuclease solubilization. Both binding activity and competence development occur simultaneously but not coordinately, since the peak of binding activity appears 3 hr after the peak of com... | 164,019 | [
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Effect of a low-molecular-weight DNA binding protein, H1 factor, on the in vitro transcription of the lactose operon in Escherichia coli. | H1 protein, a heat-stable low-molecular-weight DNA-binding factor previously described by Cukier-Kahn et al. [Proc. Nat. Acad. Sci USA (1972) 69, 3643-3647] markedly stimulates in vitro synthesis of lac-specific RNA directed by bacteriophage lambdah80 dlac or phi80 dlac DNA templates in the presence of purified E. coli... | 164,021 | [
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Idiopathic congenital hemihypertrophy with associated ipsilateral benign nephromegaly. | Two cases of idiopathic congenital hemihypertrophy with ipsilateral benign nephromegaly are presented. Excretory urography usually differentiates benign renal enlargement from Wilm's tumor in these patients. Angiography is indicated in equivocal cases. The clinical features, differential diagnosis, associated condition... | 164,043 | [
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Angiographic signs of corpus callosal tumors: a reappraisal. | Angiographic findings of eleven corpus callosal tumors are analyzed. Three new angiographic signs are demonstration of the lateral ventricular roof veins, spreading of the septal veins, and actual demonstration of corpus callosal thickening. In contrast to traditional concepts, diagnostic abnormalities were angiographi... | 164,047 | [
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[Membrane antigens of Zajdela ascitic hepatoma]. | The membrane antigens of Zajdela ascitic hepatoma cells were investigated. Living cells were studied by immunofluorescence method, and solublized membrane preparations by the precipitation reacting in agar gel. Testing of the tumor cells with organospecific anti-kidney serum caused a specific fluorescence of tumor cell... | 164,069 | [
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Function of the fat-soluble vitamins. | Much has been learned about the function of the fat-soluble vitamins in recent years. Their mechanisms are divergent ranging from a role in transcription of DNA or differentiation to a direct enzymatic activation of the gamma-carboxylation of glutamate residues of a preexisting protein. Thus the only resemblance so far... | 164,114 | [
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Islet cell tumors of the pancreas and the alimentary tract. | Functioning tumors of the pancreatic islets are now recognized as the source of clinical syndromes affecting the gastrointestinal tract which have a wide variety of catastrophic symptoms. Experiences with thirty-six cases suggest at least four separate diagnostic categories in the ulcerogenic tumor syndrome. These incl... | 164,136 | [
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[Clinical considerations and genetics of the lattice dystrophy of the cornea]. | Lattice dystrophy of the cornea is reported in 4 families. For purposes of linkage analysis we did serological tests on pertinent family members, including marker testing of the blood group systems ABO, MNSs, Rh, K, Ky, and P; protein group systems Hp, Ge, Gm, and Inv; and enzyme polymorphisms SEP, PGM, ADA, and AK. | 164,138 | [
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Neuromuscular transmission in a mammalian preparation during exposure to enflurane. | The effects of enflurane on motor nerve terminals and muscle endplates were studied in the rat phrenic nerve-diaphragm preparation using standard microelectrode recording techniques. Muscle endplate interaction with enflurane was suggested by depression of the amplitude of miniature endplate potentials (MEPP's) without... | 164,141 | [
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Growth of SV 40, adeno 7 and SV 40-adeno 7 viruses in monkey and human cells at 29 degrees and 37 degrees C. | Adeno 7 virus replicated well in human diploid (LEP) cells but only to a low degree in green monkey kidney (GMK) cells at 37 degrees C; it did not replicate in either system at 29 degrees C. At 37 degrees C SV 40 virus replicated well in GMK cells but only moderately in LEP cells; at 29 degrees C it did not replicate i... | 164,162 | [
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Experimental egg-transmission of avian reovirus. | Two experiments with an avian reovirus (FDO isolant), serologically identical to the Fahey-Crawley and WVU 2937 isolants, provided conclusive proof that egg-transmission can occur. In the first experiment, 4-day-old chicken embryos were inoculated into the yolk sac with serial dilutions of virus and subsequently hatche... | 164,174 | [
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Evidence for glucocorticoid transport into AtT-20/D-1 cells. | Glucocorticoid uptake by AtT-20/D-1 mouse pituitary adenocarcinoma cells grown in tissue culture was examined. The binding of triamcinolone acetonide, a potent synthetic glucocorticoid, by intact cells and by cell cytosol was studied at both 4 and 25 degrees. Specific binding of [3H]triamcinolone acetonide by intact ce... | 164,213 | [
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Stimulus-secretion coupling in platelets. Effects of drugs on secretion on adenosine 5'-triphosphate. | The mechanism of stimulus-secretion coupling in platelets was investigated by observing the effects of drugs on the kinetics on ATP secretion induced by either thrombin or the divalent cation ionophore A23187. The actual secretion is the same with either of these agents, since the rate constants and activation energies... | 164,214 | [
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Cold inactivation of glyceraldehyde-phosphate dehydrogenase from rat skeletal muscle. | Inactivation of apo-glyceraldehyde-phosphate dehydrogenase (D-glyceraldehyde-3-phosphate: NAD+ oxidoreductase(phosphorylating) (EC 1.2.1.12) from rat skeletal muscle at 4 degrees C in 0.15 M NaC1, 5 mM EDTA, 4 mM 2-mercaptoethanol pH 7.2 is a first-order reaction. The rate constant of inactivation depends on protein co... | 164,222 | [
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Non-allosteric regulation of the uridine kinase from seeds of Zea mays. | Uridine kinase (ATP: uridine 5'-phosphotransferase, EC 2.7.1.48) has been partially purified from ungerminated hybrid corn seed. It is associated with a soluble high molecular weight fraction from which it apparently cannot be dissociated without loss of activity. The stability of the enzyme is enhanced by the addition... | 164,226 | [
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The removal of cholesterol from aortic smooth muscle cells in culture and Landschutz ascites cells by fractions of human high-density apolipoprotein. | Ascites cells were labeled by intraperitoneal injection of [3H]cholesterol and aortic smooth muscle cells by addition of [3H]cholesterol to the serum component of the culture medium. The release of cholesterol from cells into a serum-free medium supplemented with the various "acceptors" was studied using ascites cells ... | 164,235 | [
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Solubilized DNA-dependent nuclear RNA polymerases from the mammary glands of late-pregnant rats. | Mammary gland nuclear extracts from late-pregnant Wistar or Sprague-Dwaley rats, analyzed by DEAE-Sephadex chromatography, were found to contain DNA-dependent RNA polymerases, cyclic nucleotide-binding proteins, and cyclic AMP-independent protein kinases. 1. The fractions from chromatographed nuclear extracts which con... | 164,243 | [
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The interaction of estradiol-receptor protein with the genome: an argument for the existence of undetected specific sites. | In extracts from rat and calf uterus, the steroid hormone 17 beta-estradiol stimulates the binding of its specific receptor protein to DNA. This interaction appears to be of low affinity (half of the estradiol-activated, 5S receptor bound at 300-400 mug/ml DNA) and nonspecific with respect to DNA base sequence. No bind... | 164,290 | [
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Effect of PGE1 and TSH on cAMP-dependent protein kinase activity in the thyroid. | PGE1, like TSH, can increase cAMP-dependent protein kinase activity in calf thyroid slices. The intracellular levels of cAMP produced by either of these agents alone appeared to correlate well with the degree of kinase activation. PG synthesis did not appear to be necessary for TSH action in this system, since indometh... | 164,339 | [
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Effect of Ricinus communis toxin on cyclic adenosine 3':5'-monophosphate metabolism in Yoshida ascites sarcoma cells. | Prostaglandin E1 (2.5 mug/ml) enhanced the level of cyclic adenosine 3':5'-monophosphate (cyclic AMP) three to four times in Yoshida ascites sarcoma (YS) cells cultured in vitro. When Ricinus communis toxin (RC-toxin) was added 30 min after the addition of prostaglandin E1, the enhanced level of cyclic AMP in the YS ce... | 164,448 | [
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Selective retention and formation of a delta5-androstenediol-receptor complex in cell nuclei of the rat vagina. | Cellular protein binding of a number of androstene and androstane derivatives that promote the growth of the vagina in rats has been studied. It was found that cell nuclei of the rat vagina contain a tissue-specific protein that binds 3beta,17beta-dihydroxy-androst-5-ene (delta5-androstenediol), a unique steroid causin... | 164,458 | [
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Vasopressin-sensitive kidney adenylate cyclase. Structural requirements for attachment to the receptor and enzyme activation: studies with vasopressin analogues. | Several vasopressin analogues were tested on pig kidney membranes for their ability to activate adenylate cyclase and to inhibit the binding of [8-lysine]vasopressin. Both the adenylate cyclase activation and hormonal binding were measured on the same enzyme preparation and under identical were measured on the same enz... | 164,461 | [
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Properties of a subpopulation of T cells bearing histamine receptors. | C57BL/6 mice immunized i.p. with alloantigen (P815 mastocytoma cells) develop cytolytically active thymus-derived (T) splenic lymphocytes. The definition of specific histamine receptor sites on effector T cells has been studied by measuring the in vitro effects of the hormone on cytolytic activity. Histamine was found ... | 164,483 | [
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Effect of adrenocorticotropic hormone on conditioned avoidance in rats interpreted as state-dependent learning. | Rats were given one training trial that was followed 2 days later by one test trial in a "step-out" passive avoidance task. Each rat was injected with either adrenocorticotropic hormone (ACTH) or placebo before training and before testing. Four groups of rats were used, representing the 4 possible training-testing inje... | 164,488 | [
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Respiratory viral infection in childhood. A survey in general practice, Roehampton 1967-1972. | The role of viruses and M. pneumoniae in episodes of acute respiratory illness in childhood has been studied in a London general practice. The total isolation rate was 31-7 per cent, but the rate varied from 32-6 per cent in upper respiratory infections to 64-0 per cent in pneumonia. The clinical features associated wi... | 164,499 | [
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Sero-immunity to poliovirus in children and young women: England 1972-4. | A total of 292 children's sera and 706 antenatal sera from different parts of England were tested for the presence of poliovirus neutralizing antibodies. Little vairation was found between different areas and types of community, but a lower porportion of the 5-14 year old children had antibody than younger children and... | 164,503 | [
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0.2604021,
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... |
Congenital granular-cell myoblastoma. | The clinical and pathologic features of congenital granular-cell myoblastoma in five infant girls are reported. One lesion, treated expectantly, progressively decreased in size and after 3 yr and 9 mo could not be detected, while two lesions which were imcompletely excised did not recur. It is suggested that congenital... | 164,527 | [
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0.5649999,
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0.170343,... |
Nursing staff training for an effective geropsychiatric environment. | In describing an early training program of the Gerontological Manpower Project, we have attempted to demonstrate that short-term, on-site training with a frim theoretical and empirical base, can be an effective vehicle for translating research into application. In this case, research and theory based on the importance ... | 164,539 | [
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0.01217647,
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Stimulation of protein synthesis in vivo in immature mouse testis by FSH. | Human pituitary FSH was found to increase the incorporation of tritiated lysine into testicular protein in prepubertal mice in vivo. Radioactivity was measured in washed trichloracetic acid precipitates prepared from crude testicular homogenates. The time of maximum response was 8 to 16 hr after subcutaneous injection ... | 164,545 | [
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Implantation in ovariectomized mice treated with dibutyryl adenosine 3',5'-monophosphate (dibutyryl cyclic AMP). | Experiments are described that demonstrate that uterine intraluminal injection of a 1-25 mM-solution of dibutyryl cyclic AMP (dcAMP) in phosphate buffered saline (PBS) induced implantation in ovariectomized pregnant mice. Pretreatment with progesterone was essential for this effect. When PBS was injected alone, it did ... | 164,548 | [
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Potential inhibitors of L-asparagine biosynthesis. 2. Chemistry and biological activity of beta-hydroxyaspartic acid and its derivatives. | Several derivatives of erythro-beta-hydroxy-DL-aspartic acid (1) were prepared as a potential inhibitors of L-asparagine synthetase (ASase) from rat Novikoff hepatoma. Benzylation of 1 gave the dibenzyl ester 2 which upon coupling with carbobenzoxyglycine afforded the blocked dipeptide 3. Deblocking of 3 gave glycl-ery... | 164,550 | [
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Distinction between Duchenne and other muscular dystrophies by ribosomal protein synthesis. | Ribosome concentration, ribosome distribution on sucrose density gradients, and in-vitro ribosomal amino-acid incorporation (noncollagen and collagen synthesis) were studied in muscle biopsy samples obtained from 30 patients with Duchenne muscular dystrophy, seven patients with Becker muscular dystrophy, and 10 with fa... | 164,552 | [
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Isolation and characterization of the plasma membrane from Yoshida hepatoma cells. | Plasma membranes isolated from Yoshida ascites hepatoma AH-130 by a modification of the method of T.K. Ray (Biochim. Biophys. Acta 196:1, 1970), were subfractionated into three fractions having densities (d) 1.12, 1.14 and 1.16 by discontinuous sucrose density-gradient. Membrane subfractions were characterized by elect... | 164,555 | [
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Primary tissue culture of human wart-derived epidermal cells (keratinocytes). | The formation of human skin warts may depend on transformation by human papilloma virus or result from a productive virus infection. To explore this problem, methods were developed for the primary tissue culture of epidermal cells (keratinocytes) derived from wart tissues and normal skin. Wart-derived keratinocytes con... | 164,558 | [
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... |
[Synthetic depot-ACTH, plasmacortisol levels, and asthmatic syndrome (author's transl)]. | Plasmacortisol levels were measured in 33 patients with asthmatic syndrome before and after they received treatment with 6 mg of depot-ACTH (Tetracosactid) over seven days. 75 percent of the patients showed improved VC and FEF after therapy. This effect was not in any way correlated to the basal level of cortisol, nor ... | 164,616 | [
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0.4039767,
0.2507888,
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Plasma lipids and lipoproteins in vegetarians and controls. | The possible effect of diet on plasma lipids was investigated in a group of vegetarians. Seventy-three men and 43 women who had adhered to a vegetarian diet for an average of three years were studied in the fasting state and compared with a randomly selected group of controls matched for age and sex. Mean cholesterol l... | 164,628 | [
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Demonstration that monocytes rather than lymphocytes are the insulin-binding cells in preparations of humah peripheral blood mononuclear leukocytes: implications for studies of insulin-resistant states in man. | Insulin receptors have been demonstrated on mononuclear leukocytes prepared by centrifugation of buffy coats from normal blood donors on Ficoll-Hypaque gradients. The cell type that specifically binds insulin in this mixture of lymphocytes and monocytes has never been clearly identified, although it was assumed to be t... | 164,655 | [
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Translation of Rous sarcoma virus RNA in a cell-free system from ascites Krebs II cells. | The template activities of the 60-70S RNA complex and of the 30-40S subunit RNA species of Rous sarcoma virus were tested in a cell-free protein-synthesizing system from mouse ascites Krebs II cells. Stimulation of protein synthesis over the endogenous background was about 2-fold with 30-40S viral RNA and about 1.3-fol... | 164,661 | [
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Decrease in membrane-associated actin of fibroblasts after transformation by Rous sarcoma virus. | The actin content of membranes prepared from cultured chick embryo fibroblasts has been measured on polyacrylamide gels. The actin was identified by tryptic peptide mapping. After transformation of the cells by Rous sarcoma virus, the amount of actin associated with the membranes is decreased by 30-50%. This result is ... | 164,667 | [
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Influence of altering total body sodium on angiotensin I systemic converting activity (38573) | Studies were carried out in the dog to determine the extent to which alterations in total body sodium influence the systemic conversion of angiotensin 1. When the animals were maintained on a high salt diet and DOCA, conversion of angiotensin I increased signifcantly and returned to control levels when a normal salt d... | 164,672 | [
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The effect of triazolam on the sleep of insomniacs. | The effects of three oral doses of bedtime triazolam (0.25 mg, 0.5 mg, and 1.0 mg) a new benzodiazepine, on the laboratory sleep of insomniacs were studied in a double blind design which used the following 14 consecutive night schedule: 1-4 placebo; 5-11 drug; 12-14 placebo. Effects on sleep were measured objectively b... | 164,680 | [
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0.08590756,
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0.2403368,
0.12075... |
Somatic hybridization and oncogenesis; (Mechanism of formation of malignant tumors and metastases by the action of antilymphocytic serum). | The results of experiments carried out to test some of the consequences of the earlier general theory of oncogenesis, according to which the malignant tumor cell can arise as a result of somatic hybridization of cells of different organ- and tissue-specificity, are described. In the first series a tumor induced by cell... | 164,699 | [
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[Isolation of intact liver parenchymal cells by a modified enzymatic method]. | An enzymatic method is described for isolating intact parenchymal cells from rat livers. 3--4 g cells (wet weight) could be isolated from livers of rats weighing 180--230 g. After an in vitro preperfusion of 15 minutes with a Ca-free buffer, collagenase (200 mg/1) and calcium chloride (5.2 mmol/1) were added. Perfusion... | 164,741 | [
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0.03999... |
Morphological observations of dysplastic gliomas heterotransplanted to experimental animals. | Observations concerning transplantation of 5 cases of malignant dysplastic gliomas to the anterior chamber of the guinea-pig eye have been presented. This type of gliomas, composed mainly of cytoplasm-abundant cells, show weak transplantability, slow rate of growth, and particular tendency to degeneration and necrosis.... | 164,756 | [
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0.1570523,
-0.489243,
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0.1792632,
0.1107296,
0.141513,
-0.06334973,
0.08065309,
-0.04806481,
0.02416445,
-0.1945844,
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0.04053696,
0.244353,
0.2087992,
0.246325,
0.476099,
0.2938814,
0.04419726,
0.13746... |
A cytoplasmic body in human fetal endothelium. | We describe a crystalloid-containing inclusion in the cytoplasm of human fetal cells believed to be endothelium. We do not know whether it is peculiar to the fetal period, nor do we know its function. | 164,775 | [
-0.3128152,
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... |
An experimental mouse testicular teratoma as a model for neuroepithelial neoplasia and differentiation. I. Light microscopic and tissue and organ culture observations. | The various stages of divergent neuroepithelial differentiation were studied in the solid transplants of a transplantable mouse testicular teratoma (OTT-6050) maintained in both ascitic and solid forms. They included: a) areas of undifferentiated medullary epithelium corresponding to the rare human medulloepithelioma; ... | 164,776 | [
0.1791353,
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0.1... |
Colon and rectal cancer in the young adult. | 801 patients with colon and rectal cancer were studied to assess the behavior of this cancer in the patient under 40 years of age as contrasted to the more commonly seen older patient. The younger patient had a greater frequency of advanced signs, later stages of cancer and mucoid carcinoma. However, when compared by c... | 164,809 | [
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0.5782523,
0.389015,
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... |
Erythropoietin production in renal tumors. | A review of the pertinent literature on the relation of erythropoietin production to the presence of renal neoplasm suggests that erythropoietin may be produced either directly by the tumor or indirectly by its physical effect on the adjoining normal renal tissue. The most commonly found tumors which are associated wit... | 164,817 | [
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Mechanism of colistin-induced neuromuscular depression. | The effect of a high concentration of the antibiotic colistin sulfate on neuromuscular transmission was examined by recording intracellularly from rat diaphragm blocked with tubocurarine chloride. The presynaptic effect of colistin was different from that of neomycin sulfate, which reduces the probability of acetylchol... | 164,847 | [
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0.6648007... |
Long-term effects on the health of men engaged in the manufacture of tolylene di-isocyanate. | A prospective study of workers engaged in the manufacture of tolylene di-isocyanate (TDI) was carried out over nine years. The study was in two parts: (1) assessment of the symptoms and ventilatory function of men working on the plants who did not complain of respiratory symptoms; (2) assessment of the long-term effect... | 164,881 | [
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Interaction of reduced nicotinamide adenine dinucleotide with beef heart s-malate dehydrogenase. | The interaction of NADH with s-malate dehydrogenase isolated from beef heart was studied in 20 mM potassium phosphate (pH 6.9)-1 mM EDTA, with forced dialysis, fluorescence, and temperature-jump techniques. Measurements of the change in fluorescence of NADH when it is titrated with enzyme indicate NADH bound to monomer... | 164,884 | [
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0.008950261,
... |
Conformational flexibility of angiotensin II. A carbon-13 spin-lattice relaxation study. | Carbon-13 spin-lattice relaxation times (T1) have been determined for the carbon in the octapeptide hormone [5-isoleucine]-angiotensin II in aqueous solution. Two possible models for molecular motion are considered: isotropic overall motion of the hormone with internal motion of some residues and anisotropic overall mo... | 164,885 | [
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... |
The assay and isolation of DNA rings using an ATP-dependent endonuclease. | The ATP-dependent endonuclease from Hemophilus influenzae is relatively inactive on closed or open DNA rings, yet rapidly hydrolyzes single- or double-chained linear DNA. This enzyme in combination with an exonuclease (exo VII) has been shown to spare various circular DNA molecules including those having single-chain r... | 164,888 | [
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0... |
Physicochemical characterization of Rhesus low density lipoproteins. | The serum low density lipoprotein (LDL; p 1.019-1.050 g/ml) of the normal Macaca mulatta monkey (rhesus), kept on a low-fat Purina primate chow diet, was isolated by ultracentrifugal flotation, and its physicochemical properties were compared with those previously reported for human LDL. Rhesus LDL was found to be chem... | 164,895 | [
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Studies on the active transfer of reducing equivalents into mitochondria via the malate-aspartate shuttle. | 1. The effects of mitochondrial energy states onthe extramitochondrial NADH/NAD ratio via a reconstituted malate-aspartate shuttle have been investigated. 2. The transfer of reducing equivalents into isolated mitochondria is stimulated by ATP and by electron transport. The effect of ATP is inhibited by oligomycin. The ... | 164,904 | [
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0.293646... |
Hormone action at the membrane level. IV. Epinephrine binding to rat liver plasma membranes and rat epididymal fat cells. | [3-H]Epinephrine binding to isolated purified rat liver plasma membranes is a reversible process. An initial peak in binding occurs at about 15 min and a plateau occurs by 50 min. Optimal binding occurred at a membrane protein concentration of 125mug. Rat liver plasma membranes stored at-70 degrees C up to 4 weeks show... | 164,909 | [
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Purification and characteriazation of collagenase from guinea pig skin. | Guinea pig skin col-agenase, isolated from culture medium of whole skin, was separated into two enzymatically active fractions. These two fractions have been purified extensively. Peak II fraction has been purified to homogeneity as examined by polyacrylamide gel electrophoresis. Their molecular weights are approximate... | 164,920 | [
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Essential arginine residues in D-glyceraldehyde-3-phosphate dehydrogenase. | Two arginyl residues per subunit of yeast D-glyceraldehyde-3-phoshphate dehydrogenase were modified by treatment with butanedione without significant changes in the compostion of other amino acid residues. The modified enzyme displays no dehydrogenase activity. It retains the capacity for interacting with the coenzyme ... | 164,934 | [
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0.09627... |
Microsomal (Na- +K+)-activated ATPase from frog skin epithelium. Cation activations and some effects of inhibitors. | A method is described for the extraction of microsomal ouabain-sensitive (a- + K+)-activated ATPase from separated frog skin epithelium. The method yields a microsomal fraction containing (Na+ K+)-stimulated activity in the range of 30- 40 nmol - mg -1 - min -1 at 26 degrees C. This portion which is also ouabain sensit... | 164,947 | [
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Effect of adrenergic agents on alpha-amylase release and adenosine 3',5'-monophosphate accumulation in rat parotid tissue slices. | The role of cyclic AMP in stimulus-secretion coupling with investigated in rat parotid tissue slices in vitro. Isoproterenol and norepinephrine stimulated a rapid intracellular accumulation of cyclic AMP, which reached a maximum level of 20-30 times the control value by 5 to 10 min after addition of the drug. Isoproter... | 164,957 | [
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Two types of insomnia: too much waking or not enough sleep. | The stability of sleep was examined in two kinds of induced insomnia, namely after caffeine administration and after hypnotic drug withdrawal. The duration of each episode of any one sleep stage or any episode of intervening wakefulness plus drowsiness was determined. After caffeine there was an increase in longer epis... | 164,968 | [
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The conformational states of cytochrome oxidase in the mitochondrion. | THE Soret spectrum of "resting" cytochrome oxidase in cytochrome-c depleted mitochondria has been determined. The spectrum obtained is dependent on the rate at which the oxidase is turning over. In the least active preparations, the spectrum is almost pure "oxidized" oxidase. With increasing activity the spectrum is c... | 164,988 | [
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0.1490564,
0.04856154... |
Relationship between serum cholinesterase and low density lipoproteins in children with nephrotic syndrome. | 1. A significant increase in the activity of serum cholinesterase and concentration of dextran sulphate precipitable lipoproteins, cholesterol and triglycerides was observed in sixteen children with a diagnosis of nephrotic syndrome when compared with the values obtained in 22 other normal children of comparable ages. ... | 165,016 | [
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... |
Triiodothyronine binding in rat anterior pituitary, posterior pituitary, median eminence and brain. | In vivo studies of the exchange of tracer [125-I]-L-triiodothyronine (T3) between plasma (P), and the anterior pituitary (AP), posterior pituitary (PP), median eminence (ME) and the frontal lobes of the brain (B), in the rat show that from 2.5 h onwards the concentration of new [125I]T3 in AP, PP and B were parellel to... | 165,057 | [
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0.2654025,
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-... |
Effect of dexamethasone on the secretion of thyrotropin in the rat: dose and time relations. | Serum TSH and corticosterone concentrations were measured in intact rats and in rats given TRH or exposed to short-term cold 3 h and 12 h after pretreatment with dexamethasone in various doses. Dexamethasone given 3 h before experiemtns significantly depressed both TRH- and cold-induced TSH responses at all dose levels... | 165,068 | [
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... |
Effect of temperature during preparation of rat adrenal quarters and isolated cell suspension of their ACTH responsiveness. | The effect of temperature during preparation of rat adrenal quarters or isolated adrenal cell suspension on their response to ACTH was examined through a comparison of amounts of corticosterone produced after their incubation. The response to ACTH added in vitro was considerably higher when adrenal quarters and isolate... | 165,070 | [
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0.2327105,
0.5098765,
0.09408522,
-0.014... |
Conformational studies of equilibrium structures in fragments of horse heart cytochrome c. | Ultraviolet absorption and circular dichroism studies have been carried out on horse heart apo-cytochrome c and heme-free peptide fragments obtained by cyanogen bromide cleavage of the native protein. It was noted that the various peptides assume predominantly an unordered conformation in water solution. Increasing ion... | 165,078 | [
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... |
Restoration of potassium-stimulated respiration of glycerol-treated muscle. | Agent that produced contracture in skeletal muscle, such as caffeine or K-depolarization, also caused an increased rate of oxygen consumption. Both of these functions are calcium dependent. In this study the respiratory response to K-depolarization and to caffeine was monitored in glycerol-treated and normal frog sarto... | 165,082 | [
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0.2910612,
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-0.01... |
Phosphorylation of purified thyroid plasma membranes incubated with [32-P]ATP. | Plasma membranes have been prepared from porcine thyroid glands using sucrose gradients. The fractions having a density in sucrose of 1.18 g/ml mainly contained plasma membranes and were moderately contaminated with other subcellular components as shown by marker enzyme data. Purified plasma membranes incubated in the ... | 165,113 | [
-0.341848,
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0.6071551,
0.2188502,
-0.5136139... |
The anamnestic response of the secretory immune system: A review. | Following topical immunization of the respiratory mucosa in man, persistence of antibody in the respiratory secretions can be demonstrated in some individuals for more than one year. The secretory response to replicating agents is generally more prolonged than the response to less persistent antigens. Repeat topical an... | 165,117 | [
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... |
Adenoviruses of man and animals. | Adenoviruses are capable of causing natural infections in a wide variety of vertebrates, including amphibia, birds and mammals. Although frequently causing inapparent infections, they may be associated with diseases of varying severity and localizations. The clinico-pathological manifestations most commonly associated ... | 165,118 | [
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Immunity to infections of the respiratory system in man and animals. | Itis probable that RS virus is an important etiological agent in the bovine respiratory disease syndrome. This is the conclusion of groups of workers in Europe and Japan. In this country, significant levels of neutralizing antibody have been detected in 81 percent of cattle tested, while paired sera groups showed seroc... | 165,132 | [
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0.2100933,
0.1383643,
0.07297263,
-0.2144832,
-0.06459261,
0.06484485,
-0.3424402,
0.004853551,
0.406244,
-0.359309,
0.1325504,
-0.1152813,
-0.2796533,
-0.3504446,
-0.05334055,
0.03624577,
0.1412526,
0.2528892,
-0.05094137,
0.2499318,
-0.1222087,... |
Hepatic dearterialization in 3'-methyl-4-dimethylaminoazo-benzene-induced hepatocellular carcinoma with special reference to circulatory dynamics and mitochondrial functions. | This time trend of hemodynamics and mitochondrial functions were studied to determine whether the ligation of the hepatic artery would result in an antitumor effect on 3'-methyl-4-dimethylaminoazobenzene-induced hepatic carcinoma in rats. The studies revealed that the hepatic tumors were nourished predominantly by the ... | 165,134 | [
-0.183954,
0.2892254,
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0.09967475,
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0.05110802,
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0.3052087,
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0.3371696,
0.1477273,
0.098397... |
Indirect sulphonation of mucopolysaccharides and glycogen in tissue sections with the use of bisulphite or dithionite after periodic acid oxidation. | Tissue mucopolysaccharides and glycogen can be indirectly sulphated after being oxidized by periodic acid and treated with sodium bisulphite or dithionite in aqueous solution. The sulphated sites are darkly stained by Roluidine Blue and realted dyes at pH less than 1.0. The background is very pale or colourless. The st... | 165,165 | [
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0.01587621,
0.2630456,
-0.03136194,
-0.04355... |
Regulation of galactose operon at the gal operator-promoter region in Escherichia coli K-12. | The capR (lon) product controls expression of the gal operon independently of the galR repressor. Previously, mutations of the gal operon have been isolated that are semiconstitutive and alter response to the capR and/or capT product. Such mutants imply the existence of a distinct site in the operon that responds to ca... | 165,171 | [
0.1574993,
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0.3498229,
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0.6206121,
0.2752091,
-0.647495,
0.25... |
Hydrophobic interactions of the apo-Gln-I polypeptide component of human high density serum lipoprotein. | Apo-Gln-I, the major polypeptide component of human serum high density lipoprotein, has four noninteracting hydrophobic sites which associate with alkanes, anionic detergents, and cationic detergents. Hexane and octane bind to these sites with association constants of 6.8 times 10-2 and 1.8 times 10-4 liters/mol, respe... | 165,177 | [
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0.2969357,
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0.03... |
Deoxyribinucleic acid-binding proteins in virus-transformed cell lines. | The synthesis of proteins with affinity for DNA has been studied in clones of a Syrian hamster cell line (NIL) and subclones of this line transformed by polyoma virus (NIL-Py) or hamster sarcoma virus (NIL-HSV). The results show that the synthesis of DNA-binding proteins in NIL and in its virus-transformed derivatives ... | 165,180 | [
-0.1743889,
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0.3195743,
0.2731371,
0.2950718,
-0.01913116,
-0.2103202,
... |
Glycerol as an agent eliciting small conformational changes in alcohol dehydrogenase. | Yeast alcohol dehydrogenase is an example of a protein in which the K-m for substrate is substantially decreased by the presence of glycerol. The polyol has the effect at pH 8.0 or above of decreasing K-m and K-s for substrate and of altering both the protein's intrinsic fluorescence and ultraviolet absorption differen... | 165,183 | [
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0.1644898,
0.2056643,
0.279878,
-0.1952151,
0... |
Nucleolar changes in liver before the onset of deoxyribonucleic acid replication. | A mixture of chemicals was previously devised (3, 3', 5'-triiodo-L-thyronine, amino acids, a butyryl derivative of cyclic adenosine 3':5'-monophosphate, theophylline, and heparin) that induces nuclear DNA replication in the liver of the unoperated rat (Short, J., Tsukada, K., Rudert, W.A. 7 Lieberman, I. (1975) J. Biol... | 165,195 | [
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0.03729679,
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0.1251138,
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0.1569986,
0.5824802,
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-0.1652484,
0... |
Pitfalls in the use of lead nitrate for the histochemical demonstration of adenylate cyclase activity. | The biochemistry of the lead histochemical technique for demonstrating adenylate cyclase was studied. The enzyme activity of fat cell plasma membranes, using 5'-adenylyl-imidodiphosphate (AMP-PNP) as substrate, was completely inhibited at 1 times 10- minus 4 M Pb(NO3)2 and yet at 4 times 10- minus 3 M Pb(NO3)2 precipit... | 165,205 | [
-0.1885381,
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0.2430706,
0.617748,
0.4005788,
0.3897179,
-0.04393313,
0.2... |
Radioligand receptor assay for urinary and serum hCG. | A radioligand receptor assay system for urinary hCG and serum hCG was developed, using 1100-2000 times g fractions of homogenates of pig testis. This method is specific for hCG and LH, and the limit of detection for hCG was 20 mIU, which could be significantly discriminated from zero at the 95% confidence level. A nons... | 165,212 | [
0.1730491,
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0.461025,
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0.145872,
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0.0973236,
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0.2369408,
0.05886088,
0.01835553,
0.2334621,
0.2984519,
-0.03323208,
0.0855... |
Characterization of the glucagon receptor in a pheochromocytoma. | Glucagon activated adenylate cyclase in a homogenate of a pheochromocytoma over the concentration range 1 times 10 minus 8M to 1 times 10 minus 6M. Several other hormones including adrenocorticotropin, thyrotropin, parathyroid hormone and histamine were without effect. The tumor glucagon receptor was characterized and ... | 165,216 | [
-0.1182612,
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0.0829437,
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0.1501341,
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-0.0660898,
0.4407359,
0.3349598,
0.09877367,
-0.2684302,
... |
Plasma growth hormone and slow wave sleep increase after interruption of sleep. | A comparison was made of plasma hGH and of sleep stages during one night of undistrubed sleep and one night in which sleep was interupted by an hour of enforced wakefulness folowing the end of the second NREM-REM sleep cycle in 8 normal subjects. Plasma was sampled at 15-min intervals. HGH and slow wave sleep were both... | 165,220 | [
-0.2033819,
0.1305916,
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0.1363387,
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0.2624657,
-0.1157582,
-0.0282547,
0.2448526,
0.1979375,
0.06288106,
-0... |
The isolation and partial characterization of neutrophil chemotactic factors from Escherichia coli. | Heat-stable, chemotactically active peptides have been obtained from Escherichia coli culture filtrates. They range in size between 150 and 1500 daltons and are anionic at neutral pH. Free carboxyl groups but not free amino groups appear to be required for activity. The N-terminal group may be blocked. There do not app... | 165,239 | [
-0.0824683,
0.276308,
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0.1706441,
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0.0004893359,
0.003010874,
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0.1867008,
0.07308698,
0.2933469,
-0.02698827,
0.0898154,
-0.01... |
Tumours of the parotid region. | Fifty-eight operatively treated tumours of the parotid region are presented. Of the tumours 85 per cent were benign and 15 per cent malignant. The percentage of pleomorphic adenomas was 36 per cent. During five years of observation there were no recurrences of benign tumours. Operative complications consisted of one pa... | 165,250 | [
-0.2820045,
-0.2240964,
-0.3625422,
-0.2173083,
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0.1028647,
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0.1060236,
0.007775509,
0.2206018,
-0.07310089,
0.4315113,
0.155235,
-0.072065... |
Neutrophil-mediated tumor cell cytotoxicity: role of the peroxidase system. | A cytotoxic effect of human neutrophils on mammalian tumor cells is demonstrated. Cytotoxicity depends on the presence of intact neutrophils, phagocytosable particles, and a halide cofactor and is inhibited by azide, cyanide, and catalase. Neutrophils from patients with myeloperoxidase (MPO) deficiency or defective H1O... | 165,258 | [
-0.2173883,
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0.1142609,
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0.007045146,
0.04857372,
-0.1340311,
0.2853973,
-0.13021... |
Experimental optimization of current source-density technique for anuran cerebellum. | This paper represents a systematic, semirigorous attempt to optimize the technique of current source-density (CSD) analysis experimentally. We compared different spatial differentiation formulas in terms of accuracy, aliasing, and smoothing, and provide experimental and theoretical rationale for their use. Sources of e... | 165,272 | [
0.007742113,
0.0675303,
-0.1361194,
-0.08431645,
0.2246757,
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0.2658229,
0.1842087,
0.2015646,
0.2978777,... |
Effects of activity in single sensory fibres on the discharge patterns of dorsal spinocerebellar tract cells. | 1. Electrical activity of dorsal spinocerebellar tract (DSCT) was recorded extracellularly and intracellularly in Clarke's column nucleus. 2.Trains of impluses were elicited in DSCT cells by static stretch of the hind limb muscles, and the distributions of intervals between the impulses were computed. These distributio... | 165,283 | [
-0.2287994,
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0.01153557,
0.08940947,
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0.09240061,
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0.4596892,
0.2826908,
0.1379119,
0.3606085,
... |
Detachment of structurally intact nerve endings from chromatolytic neurones of rat superior cervical ganglion during the depression of synaptic transmission induced by post-ganglionic axotomy. | 1. Electrophysiological studies showed that injury of post-ganglionic nerve fibres leads to severe and prolonged depression of synaptic transmission through the rat superior cervical ganglion, beginning within 24 h. This is in line with the results of previous studies in other species and upon other neurones. 2. elec... | 165,288 | [
0.05305033,
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0.141373,
0.1157637,
-0.06933203,
-0.007232176,
0.3186471,
0.1083961,
0.0... |
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