title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Accelerated immune complex nephritis due to mesangial overloading in spontaneous hypertensive (SHR) rats. | Immune complex nephritis induced by bovine serum albumin (BSA) and horseradish peroxidase (HRP) was superimposed upon spontaneous hypertensive rats (SHR rats) which were pretreated with polyvinyl alcohol (PVA). PVA accumulated predominantly in the mesangium, and the superimposed nephritis developed more accelerated glo... | 161,594 | [
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[Treatment of fractures of the femoral neck by primary femoral prosthesis (author's transl)]. | The authors have reviewed 230 case of fractures of the femoral neck treated by primary femoral prosthesis. The mortality was 12,6 p. 100 during the first three post operative months, and 16,5 p. 100 after three additional months. The infection rate was 13,9 p. 100, 4,7 p. 100 of the cases being severely infected. The p... | 161,638 | [
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The interaction between heparin and plasmin on amidolysis. | The effect of the interaction between heparin and plasmin not only on fibrinolytic, caseinolytic and esterolytic activities but also on amidolytic activity, since plasmin has amidolytic or amidase activity, was investigated. Following were the results obtained from these investigations: 1. Heparin enhanced amidolytic a... | 161,669 | [
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[Effect of the detergent Metaupon on replication of various phages]. | As several other surfactants do, the detergent Metaupon acts on the multiplication of bacteriophages. We investigated the influence of Metaupon on the phages phi and lambda, the cyanophage LPP-1, and the RNA-phages f 2, M 12, and Q beta by means of the agar diffusion test, pour plate test, adsorption test, and one-step... | 161,679 | [
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[Laparoscopy in chronic gallbladder diseases]. | The laparoscopy is the only riskless possibility of directly inspecting the gall-bladder, to ascertain the diagnosis of a chronic cholecystitis, further to consider the indications to internal or surgical measures. For the judgment the form of the gall-bladder, the behaviour of its wall with different colouring, oedema... | 161,681 | [
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[Study on mucopolysaccharides in human lung carcinoma tissue--characteristics in histological types (author's transl)]. | The mucopolysaccharides were prepared from human lung carcinomas of three histologically different types and the control tissue by exhaustive proteolytic digestion, quaternary ammonium chloride fractionation and column chromatography on Dowex 1 (Cl-). They were identified by chemical, enzymic and electrophoretic method... | 161,761 | [
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Permeability of muscle spindle capillaries and capsule. | The permeability of capillaries in rabbit muscle spindles, intramuscular nerves, and extrafusal muscle to intraaortically infused horseradish peroxidase (HRP) was studied. The permeability of the capsule cells of the muscle spindles was also examined. Immediately following the infusion of HRP, most extrafusal capillari... | 161,798 | [
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Structure of cerebrosides. II. Small angle X-ray diffraction study of cerasine. | Cerasine having a molecular weight of 800 differs chemically from phrenosine only in the hydroxyl group attached to the fatty acid tail which is replaced by a hydrogen atom. Nevertheless, remarkable differences between both cerebrosides are detected in the lamellae periodicities. In the range of 23--66 degrees C just o... | 161,835 | [
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Radiation aggregates of insulin. | During the irradiation of aqueous solution of insulin (pH 1.8) the decrease of original insulin molecules and the formation of radiation aggregates of insulin was studied in dependence on the concentration of irradiation solution, on the doses and conditions of irradiation (oxygenated and oxygen-free atmosphere, the pr... | 161,837 | [
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Medical geography of Moldavia: historical contribution. | The role of Hungarian surgeons and physicians in the medical care of Moldavia was discussed in its historical development. Two medico-geographical works about Moldavia in the first half of the 19th century were discussed: Andreas Wolff and the Moldavian Constantin Vernav wrote the related books. | 161,878 | [
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[Delayed healing of colonic anastomoses after tumour resection (author's transl)]. | Local tumour recurrences at colonic anastomoses in an early, curable stage are rarely missed by double contrast enema. On the other hand, the variable appearances caused by inflammatory lesions, which delay healing of the anastomosis, are often misinterpreted as recurrences. Early post-operative investigation with a wa... | 161,882 | [
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[The value of renal phlebography in the differential diagnosis of arteriographically hypo- or avascular lesions in the kidney (author's transl)]. | The present paper is an investigation into the diagnostic value of renal phlebography for differentiating between arteriographically hypo- and avascular malignant lesions in the kidney and benign renal masses. In three examinations carried out on eight patients with renal masses, phlebography was of crucial diagnostic ... | 161,886 | [
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[The Mirizzi syndrome as a cause of obstructive jaundice--its demonstration by sonography and PTC (author's transl)]. | Two patients with the Mirizzi syndrome are described and the findings on sonography and PTC care discussed. The difficulties of differentiating this from biliary obstruction due to tumour are stressed and treatment and prognosis are set out. | 161,888 | [
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[CT findings in brain abscesses (author's transl)]. | Seventeen patients with brain abscesses are reported, some with multiple lesions. The computer tomographic criteria for the diagnosis with and without enhancement are described. The advantages of computer tomography compared with other neuroradiological methods for the diagnosis and follow-up of abscesses is stressed. ... | 161,894 | [
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[The effect of selective autoperfusion through an extracorporeal circulation on the formation of arterial collaterals. Animal experimental results (author's transl)]. | In 11 mongrel dogs (10-15 kg) with ligated superficial femoral arteries the formation of collaterals induced by increased arterial pressure with an extracorporal circulation was studied. In general anesthesia a teflon tube was inserted into one deep femoral artery. The other end of this tube war introduced through the ... | 161,897 | [
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[Investigation of house-dust allergy in children (author's transl)]. | Authors were studying the relationship between the history data, the diagnostic difficulties, the skin tests and ventilatory functions after provocative inhalation and specific IgE positivity in connection with 40 cases of bronchial asthma. The most important feature of the treatment is the specific hyposensibilisation... | 161,948 | [
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[Bronchiectasis and definitive assisted ventilation (author's transl)]. | A 39 year old female with severe respiratory insufficiency by bronchiectasis is treated by assisted ventilation at home. Indication is discussed. | 162,011 | [
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Muscle spindles in the human anterior digastric muscle. | The occurrence of muscle spindles in the anterior digastric muscle in man was investigated and the fibre calibre spectrum of the corresponding nerve was determined. After removal at autopsy from five individuals of both sexes (aged 23--73), the muscles were stained with Weigert's iron hematoxylin-van Gieson stain and t... | 162,026 | [
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[The influence of climatic treatment on the levels of complement and some lysosomal enzymes in serum of patients with asthma bronchiale (author's transl)]. | It was found that the levels of CH50, C3, complement component. lysozyme, beta-D-glucuronidase, and acid phosphatase were increased in blood serum of patients with asthma bronchiale during a climatic treatment in the highmountain condition of Strbské Pleso (altitude 1,350 m). The increase of CH50 was monophasic, while ... | 162,027 | [
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[Cross reaction of specific IgE antibodies directed against cow's milk and bovine hair (author's transl)]. | Sera of 25 children living in town were examined by means of RAST on the presence of IgE antibody against milk and cow's hair antigens. 18 cases had IgE antibodies reacting with milk and 9 with cow's hair. There was correlation between the levels of these antibodies with the exception of two cases. The results give evi... | 162,028 | [
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Metallothionein: an exceptional metal thiolate protein. | Metallothioneins are unusual, low molecular weight proteins of extremely high sulphur and metabl content. They occur in substantial quantity and in multiple variant forms in parenchymatous tissues (liver, kidney, intestines) of vertebrates and certain microorganisms (Neurospora crassa, yeast). They are though to play a... | 162,047 | [
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[Occupational allergy to diazo-paper used in the textile industry (author's transl)]. | A worker of the textile industry showed an allergic contact eczema caused by diazodiethylaniline contained in diazopaper used in the manufacture of patterns. | 162,142 | [
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Free and total plasma tryptophan in endogenous depression. | The free and total plasma tryptophan concentrations were measured in 41 female depressive. Fifteen patients were subsequently treated with L-tryptophan. The free and total tryptophan were normal in the drug-free depressives and in the depressives on lithium. No significant in free and total plasma tryptophan were found... | 162,183 | [
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[Histological localization of hydrolases in the epididymis of the dog]. | Localization and activity of five hydrolases (alkaline phosphatase, adenosine triphosphatase, acid phosphatase, nonspecific esterase and leucylamino-peptidase) were evaluated histochemically in the epididymides of mature dogs. In the ductuli efferentes, cilia and apical parts of the epithelial cells displayed high acti... | 162,221 | [
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Cellular growth of cardiac muscle after birth. | Present concepts concerning DNA synthesis in the heart have been reviewed, and a speculative theory presented involving control of DNA synthesis in the developing heart. Research describing DNA synthesis in myocytes of the weanling rat heart undergoing hypertrophy has been presented. Its possible use for testing the co... | 162,244 | [
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Changes in transcriptional activity during myocardial hypertrophy. | We have demonstrated alterations in the composition of certain groups of nuclear no-histone proteins which could account for the changes in template activity. Further identification of the individual proteins essential for this regulation will aid us in our understanding of the mechanism of myocardial cell growth durin... | 162,250 | [
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Modifications of liver lysosomes in diabetic rats. | Recently investigators reported ultrastructural modifications of rat liver lysosomes which probably correlate with an increased level of blood plasma glucagon in streptozotocin-diabetes. We are investigating whether biochemical changes occur in this condition. Lysosome fragility is increased in the hepatocytes of strep... | 162,266 | [
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[Perforating injuries of the colon: primary surgery in their management (author's transl)]. | Thirty four penetrating wounds of the colon in 23 patients were treated by primary surgery. Location of the injuries on the colon, associated injuries and the nature of the missile had not affected the good quality of the results. These are encouraging an attitude towards primary surgery in the management of the colon ... | 162,299 | [
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[Prognosis of infantile scoliosis (author's transl)]. | 35 cases of infantile scoliosis were studied most of whom were followed for more than 10 years. In 11 instances, the scoliosis was present in the new born. The results are compared with those obtained by other authors. The authors consider that the signs found at the first examination as described by Mehta are not reli... | 162,303 | [
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0.1014095,
0.5759109,
0.03689814,
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0.... |
[Infected total knee prostheses treated by Papineau's technique and arthrodesis (author's transl)]. | The technique of arthrodesis of the knee after removal of an infected total prostheses is described. It was used in four cases. In the first stage, the prostheses and cement were removed, the wound was left open and knee immobilized by Hoffman external fixation. Details of the fixation are given. The second stage of fi... | 162,307 | [
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Effect of the fungal toxin (zearalenone) on the reproductive system and fertility of male and female rats. | The fertility-inhibiting effects of long-term (8 weeks) consumption of maize infected with a fungus producing F2 toxin (zearalenone) was studied in adult male and female albino rats. The fertility rate was further decreased by 25-30% if the animals were kept on contaminated diet up to 14 weeks. The gonadal weight was d... | 162,329 | [
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0.3884497,
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[Circulating immune complexes in patients with malignant diseases]. | Circulating immune complexes were determined by a solid phase C1q assay in patients with divers malignancies. In Hodgkin's disease (n = 20), immune complexes were detected only in two patients during chemotherapy. Both patients succumbed shortly thereafter. In patients with testicular malignancies (n = 18), immune comp... | 162,423 | [
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... |
[A new insulin radioimmunotest and its use in the determination of anti-insulin antibodies]. | Acetylation of insulin with 3H-acetic anhydride resulted in the predominant 3H-labeling at the aminoterminal position of the B-chain (B1). The labeled insulin was unchanged in its immunologic reactivity as compared to native insulin. It was used in a second antibody radioimmunoassay for the detection of antiinsulin-ant... | 162,424 | [
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Psychosis as a predictor of response to lithium maintenance treatment in bipolar affective disorder. | Sixty-six bipolar I lithium clinic patients were studied for a history of psychotic symptoms at some time during the course of their illness. Agreement between different sources of information was calculated, and the patient population was divided into psychotic and non-psychotic subgroups. Probability of remaining wel... | 162,485 | [
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[Incorporation of H3-uridine in vitro into normal lymphocytes and those in cases of aberration of acrocentric chromosomes]. | Literature data indicate that the formation of ribosomes is a basic function of the nucleolus. The formation of the nucleolus depends upon the function of the nucleolus organizing region (NOR). It was shown that in man the NOR locus is situated in secondary constrictions and adjacent segments of the short arms of acroc... | 162,529 | [
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-... |
Rectus hematoma: a clinical diagnosis confirmed by ultrasound. | In 2 women the diagnosis of rectus hematoma could be established by ultrasound and the further clinical course. Echoscopy is stressed as a technique which is helpful to the patient and the clinician in avoiding unnecessary operations. | 162,558 | [
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... |
ATPase stimulated by Na+ or K+ in gills of the freshwater mussel Anodonta. | 1. Microsomal preparations from the gills of the freshwater mussel anodonta cygnea cellensis show Mg2+ -dependent Na+ - or K+ -stimulated ATPase activity, which is not inhibited by ouabain. 2. Na+ - or Ka+ -ATPase activity is decreased by Ca2+, acetylcholine, choline, and tetramethylammonium, but slightly increased by ... | 162,590 | [
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... |
Long-stay patients in the London Borough of Tower Hamlets. | In September 1974 a study was made of all residents of the East London Borough of Tower Hamlets, aged 65 or more, who were known to have been receiving continuous medical and nursing care in hospital for more than a year. There were 91 geriatric and approximately 100 psychiatric patients, representing just under 1 per ... | 162,614 | [
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0.127704,
0.38078... |
A placebo controlled trial of viloxazine with and without tranquillizers in depressive illness. | Two double-blind four-way crossover studies are reported, comparing the antidepressant effect of 14-day courses of: viloxazine, viloxazine with a tranquillizer either perphenazine or diazepam or tranquillizer alone, against a placebo. In one study the antidepressant effect of viloxazine at a dose of 150 mg daily was st... | 162,677 | [
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0.214687,
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0.03457645,
-... |
Management of ascending suture line sepsis by excision on the ascending aorta and insertion of a left ventricular apex to aorta conduit. | A new technique used in the management of infection of an aortic suture line following aortic valve replacement and subsequent episodes of severe hemorrhage resulting from suture line disruption is described. In a planned, staged procedure, a left-ventricular-apex-to-aorta conduit was inserted followed by excision of t... | 162,776 | [
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0.20819,
... |
A multisomatic axon in the central nervous system of the leech. | There is one particularly large axon in the medial bundle of the nerve cord of the leech. It extends along the entire length of the cord and is connected to a single cell body in each ganglion. The cell bodies in adjacent ganglia are tightly electrically coupled, and dye injected into one cell body can diffuse along th... | 162,801 | [
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0.3595386,
0.1852504... |
Interaction of amino acids and cyclic AMP on the release of insulin and glucagon by newborn rat pancreas. | Splenic lobes from the pancreas of newborn rats (48-64) hr. were used for the in vitro investigation of cyclic AMP, glucose and amino acid interaction in hormonal secretion. The slight discrepancy found in glucagon relaease with radioimmunoassay and binding assay to specific receptors in liver does not affect the rati... | 162,877 | [
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0.09055502... |
Mutants of chinese hamster cells resistant to adenosine. | Chinese hamster cells do not grow in medium containing high concentrations of adenosine because pyrimidine biosynthesis is inhibited. Adenosine metabolism was examined in two mutant cell lines isolated on the basis of resistance to adenosine. One line was deficient in adenosine kinase suggesting that high intracellular... | 162,911 | [
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0.... |
Treatment of variola major with cytosine arabinoside. | A controlled study of the efficacy of cytosine arabinoside in the treatment of patients with variola major was performed. Cytosine aravinoside was given intravenously at a dose approximating 3 mg/kg of body weight every 24 hr for up to seven days. All nine patients receiving cytosine arabinoside and four of the 11 pati... | 162,924 | [
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0.6022149,
0.138155,
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0... |
Comparison of exchange of alpha-tocopherol and free cholesterol between rat plasma lipoproteins and erythrocytes. | The simultaneous exchange of (3h)tocopherol and (14C)cholesterol between rat plasma, rat plasma lipoproteins, and RBC was studied in vitro to compare quantitavely (a) the fractional exchange rates and (b) the half-times for isotope equilibration. In all incubations of RBC with plasma or with plasma lipoprotein fraction... | 162,930 | [
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0.2250501,
-0.130... |
Parametric studies of dorsal horn neurons responding to tactile stimulation. | Dorsal horn neurons responding to tactile input were recorded in segments L3-S2 of unanesthetized, low-spinal cats. Single units were characterized with regard to receptive field (RF) location, RF size and shape, spontaneous discharge rate, central delay, and convergence of four tactile afferent types. 1. RF size incre... | 162,943 | [
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0.3489001,
0.0162... |
Radiocolloid scans in evaluating splenic response to external radiation. | By use of 99mTc-sulfur colloid, splenic size as well as liver/spleen ratio of ratioactivity was determined after external radiation of the abdomen. In six patients receiving about 2,000 R whole-abdominal radiation, there was no atrophy of the spleen or abnormal distribution in the liver/spleen ratio of radioactivity (t... | 162,950 | [
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0.329546,
0.04075978,
0.06487153,
... |
A review of tumor antigens in gynecologic malignancies. | Evidence for the presence of tumor-associated gynecologic tumor antigens from our laboratory and others is presented. Tumor-associated antigens have been described for invasive carcinoma of the cervix and mucinous carcinoma of the ovary with cross-reacting antigens in malignant vulvar tissue. The provocative finding of... | 162,963 | [
-0.2469228,
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0.1880144,
0.163407,
-0.3343732,
... |
Minimal growth requirements for Clostridium perfringens and isolation of auxotrophic mutants. | The minimal growth requirements for two strains of Clostridium perfringens were defined, and both synthetic and semisynthetic plating media were developed. Plate counts of the wild-type strains on both of these minimal media were equivalent to those on complex media. A number of auxotrophic mutants of each strain were ... | 162,964 | [
-0.3103514,
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0.3329323,
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0.1929005,
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Dynamic scintigraphy of primary and secondary malignant intracranial neoplasms. | Dynamic images and arteriograms were reviewed in patients with proved primary and secondary malignant intracranial neoplasms. In 44% of the patients with glioblastomas and 23% of those with metastatic lesions, radioactivity appeared early in the dynamic imaging sequence. This was related to the presence of arteriovenou... | 163,024 | [
-0.1646649,
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0.4217853,
0.07496774,
0.2847578,
0.3537245,
0.01357026,
0.006535125,
... |
Irradiated lung cancer. An autopsy analysis of spread pattern. | The spread pattern was studied in 48 autopsied cases of irradiated, apparently localized lung cancer. Disease was found in the upper abdomen in 52%, in the brain in 8.7%; in the bones in 20.8%; and confined to the thoracic cavity in 27%. Radical irradiation controlled 38% locally. The pattern of metastasis in these irr... | 163,026 | [
-0.0312602,
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0.2907503,
0.0959621,
0.3499949,
0.2862122,
0.03182385,
... |
Endogenous cyclic adenosine monophosphate in tissues of rabbits fed an atherogenic diet. | Rabbits fed a high cholesterol diet experienced a significant increase in plasma adenosine 3,5-monophosphate (cyclic AMP), which was simultaneous with the increase in plasma cholesterol. The content of cyclic AMP in atherosclerotic lesion areas of rabbit aortic intima-media was significantly higher (0.24 picomole per m... | 163,039 | [
-0.4240427,
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0.3227723,
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-0.2011692,
0.3951481,
0.06998935,
-0.1292332,
... |
Radionuclide angiography in juvenile angiofibroma of the nasopharynx. | Radionuclide angiography was performed by intravenous injection of 99mTc-pertechnetate and recorded by serial gamma camera scintiphotographs. Its usefulness as a prebiopsy or preoperative procedure is demonstrated by two case reports of angiofibroma of the nasopharynx and it was also found to be useful for radiation th... | 163,070 | [
-0.2187313,
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-0.7227566,
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0.1142243,
0.341705,
-0.06435145,
0.2704907,
0.007283438,
-0.210453... |
Amyotrophic lateral sclerosis. Inclusion bodies in a case of the classic sporadic form. | Postmortem light and electron microscopic studies of a 52 year old black male who died 17 months after the onset of upper and lower motor neuron signs showed: (1) degeneration of cortico-spinal tracts, (2) loss of spinal neurons and gliosis and (3) cellular inclusions with neurotubules, neurofilaments and granular mate... | 163,072 | [
-0.08626577,
-0.1910859,
-0.05834479,
-0.2258961,
-0.02124934,
-0.3009233,
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0.1351261,
0.05532586,
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0.2209633,
0.5456519,
0.070047... |
Centronuclear myopathy: histochemistry and electron microscopy. Report of two cases. | In two new cases of centronuclear myopathy, histochemical findings included failure to differentiate fiber type with oxidative enzymes, the presence of core glycogenosis, and core acid phosphatase activity. Fluorescence microscopy demonstrated autofluorescent lipochrome in fiber centers and nonspecific fiber injury in... | 163,076 | [
-0.2430329,
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0.04599721,
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0.04746756,
0.0065704,
0.2166444,
0.149348,
0.10244... |
Magnetic resonance studies on the mitochondrial divalent cation carrier. | Measurements of water proton spin relaxation enhancements (epsilon) can be used to discriminate high-affinity binding of Mn-2+ or Gd-3+ to biological membranes, from low-affinity binding. In rat liver mitochondria, epsilon b values of approx. 11 are observed upon binding of Mn-2+ to the inner membrane, while internal o... | 163,099 | [
-0.3571001,
0.003011293,
-0.3215815,
0.03100376,
0.08862206,
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0.09486749,
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0.2879735,
0.3393945,
0.312609,
0.003302938,
... |
Generation of spike trains in CNS neurons. | The membrane potential waveforms to be expected from many asynchronous inputs to CNS neurons are described, along with modes for repetitive firing through which the input waveforms are converted into spike trains. Area beneath a postsynaptic potential (PSP), rather than PSP peak height, is shown to be an important para... | 163,121 | [
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0.12... |
Utilization of triaryl phosphates by a mixed bacterial population. | A mixed bacterial population that has been isolated by enrichment culture is capable of growth on Fyrquel 220, a commercial triaryl phosphate lubricant, as sole carbon source. The mixture was dominated by a yellow, Gram-negative rod which made up greater than 60% of the mixture. However, all attempts to grow this organ... | 163,128 | [
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0.2928882,
-0.167695... |
The evaluation of abdominal masses in children with emphasis on noninvasive methods. A roentgenographic approach. | Intravenous urography with total body opacification, and tomography as required, often give the most information toward evaluating abdominal masses in children. Ultrasonography is a noninvasive procedure which defines normal structures and differentiates cystic and solid tumors. The combination of these studies gives s... | 163,141 | [
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... |
Phospholipid biosynthesis: the activity of phosphatidic acid phosphohydrolase in the developing lung and amnionic fluid. | The presented data suggest that PAPase may, indeed, be important in the biosynthesis of lung phospholipids. The observed increase in the specific activity of rabbit lung precedes the "surge" of phosphatidylcholine concentration and surfactant biosynthesis by at least 24 hours. In human amnionic fluid, PAPase specific a... | 163,170 | [
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0.06659438,
0.2260145,
0.3887897,
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Effect of luteinizing hormone and cyclic adenosine 3',5'-monophosphate on steroidogenesis in the ovarian follicle of the rabbit. | Mature ovarian follicles have been isolated from estrus rabbits and the effects of gonadotropin and cyclic AMP on steroidogenesis in this tissue determined. Gonadotropins used include LH, FSH, and prolactin; follicular levels of progesterone, 17-hydroxyprogesterone, testosterone and 17beta-estradiol in all experiments ... | 163,186 | [
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Enzyme histochemical investigation of an adenomatoid tumor. | Enzyme histochemical study of an adenomatoid tumor of the epididymis revealed an enzyme pattern identical to that of the rete testis. Histogenesis from the same primordium may be suggested. | 163,222 | [
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0.22180... |
Association of feline leukemia virus with lymphosarcoma and other disorders in the cat. | Two hundred fifty Boston cats with disorders such as lymphosarcoma, myeloproliferative disease, anemia, glomerulonephritis, pregnancy abnormalities, feline infectious peritonitis, toxoplasmosis, and various bacterial infections were examined for feline leukemia virus (FeLV) by immunofluorescence. Antibody titers agains... | 163,223 | [
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0.06505554,
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Fluorescent and spin label probes of the environments of the sulfhydryl groups of porcine muscle adenylate kinase. | The environments of the two sulfhydryl groups of procine muscle adenylate kinase have been investigated by chemical modification reactions. The results indicate that the environments of the two-SH groups of procine muscle adenylate kinase are markedly different and that substrates induce conformational changes in the e... | 163,231 | [
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The interaction of inhibitors of proteolytic enzymes with 3-methylhistidine-57-chymotrypsin. | The inhibition of proteolytic enzymes by protein inhibitors is accompanied by the formation of unusually stable complexes. The recognition of a specific substrate-like amino acid on the inhibitor is believed to be the initial event of the inhibitory process. In addition to the interactions involved in the binding of a ... | 163,242 | [
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Interaction of flavins with electron-rich metals. | A complex of the electron-rich ion Cu(I) with the flavoquinone analogue 10-methylisoalloxazine has been synthesized and characterized by x-ray methods. The complex is unstable to oxygen. It is black-green in color, in contrast with the bright yellow, orange, or orange-brown crystalline complexes of 10-methylisoalloxazi... | 163,244 | [
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0.19554,
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... |
Specific binding of 1alpha,25-dihydroxycholecalciferol to nuclear components of chick intestine. | Specific binding of 1alpha,25-dihydroxycholecalciferol to macromolecular components of small intestinal mucosa nuclei is demonstrated in vitamin D-deficient chicks. The nuclear 1alpha,25-dihydroxycholecalciferol-macromolecule complex was isolated on sucrose density gradients and sediments at 3.7 S in the presence of 0.... | 163,254 | [
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Electron microscopic studies of proteoglycan aggregates from bovine articular cartilage. | Proteoglycan aggregates from bovine articular cartilage have been visualized by electron microscopy of mixed proteoglycan-cytochrome c monolayers. The proteoglycan aggregates consist of proteoglycan subunits arising laterally at fairly regular intervals (20 to 30 nm) from the opposite sides of an elongated filamentous ... | 163,258 | [
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... |
Deoxypyrimidine kinases of herpes simplex viruses types 1 and 2: comparison of serological and structural properties. | The kinetics of formation, the stability at 40 degrees C and the serological properties of thymidine kinase and deoxycytidine kinase activities induced by herpes simplex virus have been examined. The results are consistent with the hypothesis that both activities are carried on the same molecule-a deoxypyrimidine kinas... | 163,287 | [
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0.09106483,
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Effects of semistarvation on rat liver, kidney, and heart mitochondrial function. | Two groups of rats were provided simultaneously with a commercial stock diet for a period of 7 days. One group was fed ad libitum (control), and the other was restricted to one-fourth of the daily intake of control animals (semistarved). Body weight declined significantly in semistarved rats whereas body weight of cont... | 163,302 | [
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0.6226392,
0.1542841,
0.... |
Modification of nuclear restriction in vitro by plasma from tumor-bearing animals. | Putative regulatory macromolecules, which may be useful in diagnosis or tumor detection, were identified in the peripheral blood plasma of tumor-bearing animals. We monitored the components by measuring their ability to stimulate messenger RNA (mRNA) release from isolated nuclei in a cell-free system of rat liver nucle... | 163,310 | [
-0.04900001,
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0.2063499,
0.1514087,
0.07343736,
-0.007217... |
Evaluation of dye exclusion and colony inhibition techniques for detection of polyoma-specific, cell-mediated immunity. | Cellular immunity directed against polyoma virus-induced antigen was observed with C3H/HeJ splenic lymphoid cells from mice sensitized by a short-term immunization schedule with syngeneic polyoma 4198 and 4198V tumor cells. Polyoma specificity of the response was shown by demonstration that splenic cells from DBA/2J an... | 163,318 | [
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Virus envelope markers in mammalian tropism of avian RNA tumor viruses. | Pseudotypes of vesicular stomatitis virus were prepared with avian sarcoma viruses and avian leukemia viruses representing five different subgroups. These pseudotypes display a host range restricted to that of the avian tumor virus when assayed on avian cells and are neutralized by subgroup-specific antisera. The effic... | 163,337 | [
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Products of complementation between temperature-sensitive mutants of simian virus 40. | Temperature-sensitive mutants of the D complementation group of simian virus 40 exhibit delayed complementation. Analysis of the thermal stability, kinetic profiles in temperature shift experiments, and progeny of complementation have led to the hypothesis that delayed complementation is not true complementation, but t... | 163,338 | [
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DNA infectivity and the induction of host DNA synthesis with temperature-sensitive mutants of simian virus 40. | Host DNA synthesis is induced when CV-1 (monkey kidney) cell cultures are infected at 40 C with wild-type virions or with temperature-sensitive Simian virus 40 mutants of the "early" complementation group A. Host DNA synthesis is not induced when cultures are infected with mutants of the late complementation group D. T... | 163,339 | [
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... |
Characterization of human papovavirus BK DNA. | The DNA of the BK virus (BKV) human papovavirus was found to be heterogeneous, consisting of at least four discrete species of DNA. Only the largest of these four species, BKV DNA (i), which has a molecular weight calculated to be 96% that of simian virus 40 (SV40) DNA, was infectious. Homogeneous preparations of BKV D... | 163,342 | [
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Genetic transmission of endogenous N- and B-tropic murine leukemia viruses in low-leukemic strain C57BL/6. | Spontaneous expression of endogenous N- and B-tropic murine leukemia viruses was stu1bb), DDD (Fuv-1nn), DDD-Fvr (fv-1nn), (DDD or DDD-Fvr times C57BL/6)F1, and 16 partially inbredlines with either the Fv-1nn or Fv-1bb genotype, which had been established from hybrids between C57BL/6 and DDD-Fvr. When tested at middle ... | 163,359 | [
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0.213993,
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... |
Avian pox in Florida sandhill cranes. | Cutaneous elevations were present on the feet, legs and heads of four Florida sandhill cranes, Grus canadensis pratensis, (one free-living, three penreared birds). As a result of examination of the elevations by light- and electron microscopy, it was determined that the lesions were caused by poxvirus. This is the firs... | 163,382 | [
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0.4470325,
-0.297901... |
Cytoplasmic inclusions in pulmonary macrophages of cigarette smokers. | Alveolar and bronchiolar spaces in the lungs of cigarette smokers usually contain numerous macrophages with pigmented cytoplasmic granules. By electron microscopy the pigmentation appears to be due, at least in part, to increased numbers of lysosomes and phagolysosomes. Within these cytoplasmic organelles, structures a... | 163,418 | [
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0.08541316,
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Human muscle fiber fine structure: morphometric data on controls. | Muscle fiber fine structure was quantitatively analyzed in 70 longitudinally and 65 transversely sectioned fibers from 10 control subjects without weakness. The average mitochondrial fraction of the fiber volume is close to 4 percent and the mean size of a mitochondrion is about 0.1 mum2. The sarcotubular surface area ... | 163,452 | [
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... |
[Study of the action of tolbutamide on the hypothalamo-hypophyseal-adrenocortical system in normal and obese subjects]. | Changes in plasma cortisol during the tolbutamide test were evaluated in normal subjects and in obese patients with a normal (D = 60,1 plus or minus 8,3) or reduced (D = 23,2 plus or minus 9,5) blood sugar decrease coefficient. Increases were noted in normal subjects (from 14,0 plus or minus plus or minus 2,9 mug/100 m... | 163,455 | [
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... |
Multiple unit activity study of brain stem and limbic structures during environmental habituation and circadian rhythm. | Multiple unit activity (MUA) of brain stem, hypothalamic and limbic structures was studied during habituation to a novel environment and circadian rhythm in chronically implanted freely moving rats. MUA was analysed in the mesencephalic reticular formation (MRF), area hypothalami posterior (PH), basal nuclear group of ... | 163,465 | [
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0.1175331,
... |
The discharge crisis: the experience of families of psychiatric patients. | Families of 16 psychiatric patients were interviewed immediately prior to discharge regarding the impending discharge of their relative, events prior to admission, and the families' impression of the hospitalization. Despite wide variation sample families' descriptors and differences in exposure to the treatment settin... | 163,471 | [
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0.0004580395,
0.002036495,... |
Sleep and cardiac rhythm in the gray seal. | Telemetric studies of electroencephalograms, electrocardiograms, and electroculograms and concurrent observations of behavior revealed that seals can sleep underwater, on the surface, or while hauled out. Rapid eye movement preceded slow wave sleep and was accompanied by increased respiratory rate and rhythmic tachycar... | 163,484 | [
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-0.08699956,
-0.06... |
The inhibition of c-AMP-phosphodiesterase by phenobarbitone. | The early effects of phenobarbitone, theophylline, thyroxine and of combinations of these drugs, on rat liver microsomal aniline hydroxylase activity, were studied, and the results were compared with the effect of phenobarbitone on purified c-AMP-phosphodiesterase in vitro. The stimulatory effect of phenobarbitone on h... | 163,503 | [
-0.1293295,
0.1024098,
-0.571254,
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0.2494221,
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0.1755735,
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0.05264224,
0.2579186,
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0.5090264,
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0.1907151,
-0.1774918,
0.3023173,
0.4131849,
0.068428,
-0.0126254,
0.085... |
The sick-sinus syndrome in Africans. | Fifteen cases of the sick-sinus syndrome in young Negroes are presented. The etiology was unknown in all cases; organic heart disease was absent. The very high default rate suggests that the prognosis may be grave. This disorder is by no means uncommon in young persons in tropical countries and the dangers of a mistake... | 163,570 | [
-0.07153881,
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0.06819915,
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0.1237886,
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-0.5351689,
0.01241431,
0.176621,
-0.1074218,
-0.04746933,
0.3094616,
-0.482051... |
Porcine malignant hyperthermia: effects of halothane on mitochondrial respiration and calcium accumulation. | Vastus lateralis muscle was excised from normal pigs and from pigs susceptible to malignant hyperthermia. Anesthesia consisted of diazepam, N2O:O2, and a lidocaine field block. In the susceptible (MHS) pigs, respiratory control in mitochondria of excised muscle was normal, while electron transport was accelerated. Glut... | 163,600 | [
-0.04144544,
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0.1021559,
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0.008744868,
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0.1836425,
0.2211906,
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0.3708814,
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-0.01736279,
0.2313134,
-0.1061493,
0.2764356,
0.2188873,
-0.197978... |
Collagenolytic activity of some marine bacteria. | Reconstituted, acid-extracted collagen was used to prepare a medium to screen proteolytic marine bacteria for their ability to elaborate collagenolytic enzymes. The medium was resistant to solubilization by trypsin, hyaluronidase, chondroitinase ABC, and various marine proteinases, but was readily hydrolyzed by commer... | 163,614 | [
-0.02730244,
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0.4373393,
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0.447735,
0.3882104,
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0.03218006,
0.2577719,
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0.1028426,
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0.1626088,
0.01798898,
0.1980678,
0.4055876,
0.1325142,
0.04708736,
... |
Absence of nyctohemeral variation in stress-induced ACTH secretion in the rat. | Changes in plasma ACTH concentrations were measured in the adult male rat following a stressor in order to ascertain if there is a nyctohemeral variation in ACTH secretion following stress. The immuno-reactive ACTH concentrations obtained following a 2.5-min hind-leg tourniquet at 0400 or 1600 hours in pentobarbital-an... | 163,635 | [
0.08181166,
-0.07768773,
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0.3317538,
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0.2494293,
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0.2613392,
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0.304888,
-0.06849,
0.09360407,
0.1901843,
... |
Autoantibodies with antilipoprotein specificity and hypolipoproteinemia in patients with cancer. | Sera from 151 patients with a variety of cancers were screened for antibody-like activity against lipoproteins. Eighteen % of the sera exhibited activity against autologous and homologous high-density lipoproteins and 3% exhibited activity autologous and homologous low-density lipoprotiens. Antibody-like binding was pr... | 163,682 | [
0.02239936,
-0.1574086,
-0.089843,
0.09574068,
0.04600821,
-0.1588193,
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0.4116188,
0.239529,
0.2625361,
0.2828093,
0.3116973,
0.08238646,
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0.01719669,
0.02576263,
0.2208742,
0.07108998,
-0.2005317,
-0.1898215,
... |
Evaluation of irradiation-plus-urethan-induced murine leukemia virus "release" using a new method for quantitation of oncornaviruses in tissues. | The quantity of C-type RNA tumor viruses in homogenate-sonicates of thymus-bone marrow tissues of C57BL/6J and RFM/Un mice 10 days after irradiation (X-rays or gamma-rays)-plus-urethan treatments is no greater than that in thymus-bone marrow homogenates from nontreated control mice. These results indicate that the leu... | 163,695 | [
-0.333059,
-0.01668645,
-0.1289617,
-0.1839136,
0.1382696,
-0.2834474,
-0.251779,
0.04079372,
0.2338085,
0.0377913,
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-0.111218,
0.3213612,
0.1350181,
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0.0872786,
0.01690032,
-0.1741131,
0.02909886,
0.013033,
0.2748472,
-0.366548,
-0.1793941,
0.22... |
A mixed-immunoglobulin rosette technique for detection of antibody to feline oncornavirus-associated cell membrane antigen. | A mixed-immunoglobulin rosette technique has been developed for the detection of antibodies to feline oncornavirus-associated cell membrane antigens. Lymphoblastoid cells infected with feline leukemia virus were incubated with test sera and then fixed in paraformaldehyde. They were then exposed to a rabbit anti-cat imm... | 163,696 | [
0.02095834,
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0.1272001,
0.09313431,
0.08180912,
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0.3676088,
0.3217734,
0.3371258,
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0.1973625,
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0.05909511,
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0.1646786,
0.04417941,
-0.107432,
-0.2876547,
... |
The presence of histone H1degree in human tissues. | Histone Hidegree was found to be present in a number of human tissues. It constituted 50% of the total 5% perchloric acid-soluble histone in human breast, 35%in thyroid, 12 to 18% in adrenal, and 7% in parathyroid tissues. The quantities of histone Hldegree in these human tissues were large compared with the amounts fo... | 163,699 | [
0.08136414,
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0.1093237,
-0.213253,
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0.005930159,
0.1282922,
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0.4079866,
0.1123722,
0.3918183,
0.2846349,
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-0.3876863,
0.001057727,
0.08937497,
0.03458682,
0.4965042,
0.3072163,
-0.4014568,
... |
Vitiligo and dysgammaglobulinemia. A case report and family study. | This report concerns an 8 year old female with vitiligo and dysgammaglobulinemia characterized by absent IgA, very low IgG, and normal IgM. The t-cell immune system was intact but other family members had low levels or absence of IgA. The possible relationship of dysgammaglobulinemia and vitiligo is discussed along wit... | 163,713 | [
0.007563879,
-0.195782,
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-0.2485703,
0.222004,
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-0.2525072,
0.1170033,
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0.10977,
0.3056111,
0.425103,
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0.1609357,
-0.1993562,
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-0.01351642,
0.3180602,
-0.1964023,
0.1817815,
0.2171877,
0.01772801,
0.154... |
Age-related changes in glucocorticoid binding by rat splenic leukocytes: possible cause of altered adaptive responsiveness. | Splenic leukocytes of senescent rats (24-26 mo) exhibit a 60% reduction in cortisol-induced inhibition of 3-H-uridine uptake when compared to mature adult animals (12-14 mo). The degree of inhibition is directly proportional to cortisol dosage up to 2 X 10-6 M. Specific binding of physiological (nanomolar) concentratio... | 163,772 | [
0.08613048,
-0.1847186,
-0.2872702,
-0.1657938,
0.3216723,
-0.3092081,
-0.2428852,
0.15923,
0.007312431,
0.2289901,
0.004926176,
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0.2383678,
0.1359026,
-0.8472572,
0.09751414,
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-0.0984108,
-0.2118072,
0.435122,
0.2115372,
0.1207228,
-0.07066588,
-... |
Immunological comparison of various human pregnancy-associated plasma proteins. | Direct immunodiffusion comparison with specific antisera demonstrated that all of the four pregnancy-associated plasma proteins (PAPPs) described in our laboratory are distinct from the pregnancy zone protein (von Schoultz); alpha2-pregnoglobulin (Berne); pregnancy-associated alpha2-glycoprotein (SP3) (Bohn); new serum... | 163,802 | [
0.139916,
-0.4322376,
0.08409636,
0.1523055,
0.1614714,
-0.1446112,
-0.4631196,
0.06607245,
0.6457821,
0.2962715,
-0.09708092,
0.3125691,
0.2236293,
0.01381878,
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-0.2096996,
-0.408923,
-0.2090055,
0.1327725,
0.2140768,
0.07469195,
0.1240731,
-0.4352732,
-0.05... |
Biosynthesis of branched-chain amino acids in yeast: effect of carbon source on leucine biosynthetic enzymes. | The three enzymes in the leucine biosynthetic pathway of yeast do not exhibit coordinate repression and derepression in response to the carbon source available in the culture medium. Growth in an acetate medium results in derepression of the first enzyme in the pathway, alpha-isopropylmalate synthase, and repression of... | 163,818 | [
-0.1205339,
-0.526181,
-0.1261453,
-0.1022898,
0.1684217,
-0.08138837,
-0.1753595,
0.01061682,
0.1589359,
0.04529126,
0.1010154,
-0.4061994,
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-0.09205119,
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0.166593,
-0.4165364,
0.1601664,
-0.2209085,
0.1934492,
0.4190821,
0.3864791,
0.007544958,
0.... |
The generation of O2-by the interaction of the hemolytic agent, phenylhydrazine, with human hemoglobin. | Phenylhydrazine reacts with adult oxy- or methemoglobin in the presence of molecular oxygen to generate O2-. The mechanism of the reaction apparently differs in each case. The generation of O2- is monitored by following the reduction of ferricytochrome c or the oxidation of epinephrine. | 163,828 | [
-0.4171971,
-0.02237582,
-0.2058923,
0.1141804,
0.1075758,
0.0943746,
-0.1682957,
0.02623138,
0.0461027,
0.07120349,
0.1228826,
0.288975,
-0.2747309,
0.05208834,
-0.422087,
-0.4122856,
-0.2124952,
0.08590224,
-0.03616102,
0.1214021,
0.2433375,
0.1061035,
-0.04063028,
-0... |
Macrophages activated in vitro with lymphocyte mediators kill neoplastic but not normal cells. | Normal guinea pig macrophages incubated for 3 days in vitro with mediator-rich lymphocyte supernatants become cytotoxic for the syngeneic tumors, line 1 hepatoma and MCA-25 fibrosarcoma. Under identical experimental conditions the survival of two normal syngeneic cell types, fibroblasts and kidney cells, was not affect... | 163,856 | [
-0.2105813,
-0.1384569,
-0.1642374,
-0.2077404,
0.2926654,
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-0.1178553,
0.1512788,
0.02365082,
-0.05455665,
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0.03805763,
0.1672397,
0.01182478,
-0.3736434,
-0.2352519,
-0.5340626,
-0.0287194,
-0.01141591,
0.6362509,
0.2778808,
0.1594004,
-0.04757344,... |
Mechanism of the suppressive effect of interferon on antibody synthesis in vivo. | Mouse interferon preparations significantly suppress the in vivo antibody response to sheep red blood cells (SRBC), a thymus-dependent antigen, and to Salmonella typhimurium lipopolysaccharide (LPS), a thymus-independent antigen. It is also possible to effect the late responses of antigen sensitive "memory" cells obser... | 163,863 | [
-0.1071184,
-0.09352288,
-0.3947345,
-0.2708353,
0.2624761,
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-0.01735935,
0.04155916,
-0.1290584,
0.09730286,
-0.05129039,
0.09720633,
0.2012076,
0.2319546,
-0.3198976,
0.03585209,
0.02317806,
-0.1690519,
0.004233023,
0.3043705,
0.5064936,
-0.2377315,
-0.156442... |
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