title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Swine aortic smooth muscle in tissue culture. Some effects of purified swine lipoproteins on cell growth and morphology. | Smooth muscle cells (SMC) were grown from inner media explants of swine aorta and used as a model for studying the role of lipoproteins in atherogenesis. These cultured cells retain the characteristics of SMC through multiple passages. Cell growth curves, in time, were obtained by using standard counting techniques, SM... | 182,413 | [
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Starvation in man. | Starvation entails a progressive selection of fat as body fuel. Soon after a meal glucose utilisation by muscle ceases and fatty acids are used instead. Ketoacid levels in blood become elevated over the first week, and the brain preferentially uses these instead of glucose. The net effect is to spare protein even furth... | 182,420 | [
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Newer aspects of parathyroid chemistry and physiology. | We have attempted to integrate in this review many recent studies on the formation, packaging and secretion of parathormone by the parathyroid gland. We have shown that substantial new insights have been gained into this complex cellular operation. Continuing investigation should clarify many of the outstanding questio... | 182,434 | [
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Testosterone-binding protein in reproductive tracts of fetal rats. | Testosterone-binding proteins may mediate the induction of Wolffian duct differentiation by testicular testosterone. The presence of such protein(s) was sought in reproductive tracts of 14.5-21.5-day-old fetal rats. Supernatant fractions (127,000 x g) were equilibrated with [3H]T) +/- radioinert testosterone in Tris - ... | 182,453 | [
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An approach to the anabolic action of androgens by an experimental system. | As skeletal muscle is more developed in the male than in the female, it is supposed that androgens might be responsible for myotrophic or anabolic action. In this respect, many studies were made to try to answer the question: are androgens (or some of their metabolites) responsible for myotrophic action and by what mec... | 182,485 | [
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Binding of a metyrapone spin label to microsomal cytochrome P-450. | Probing of the active site of microsomal cytochrome P-450 was carried out with a spin label derived from 2-methyl-1,2-bis(3-pyridyl)-1-propanone (metyrapone). Its optical binding spectra to cytochrome P-450 resemble the spectra with metyrapone. The electron paramagnetic resonance spectrum of the spin label in microsome... | 182,488 | [
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Activity and subcellular distribution of protein kinase dependent on adenosine 3':5'-monophosphate in liver from normal and adrenalectomized rats. | We have examined whether glucocorticoids control the activity and (or) the subcellular distribution of protein kinase dependent on cyclic AMP (adenosine 3':5'-monophosphate), since they influence cyclic-AMP-dependent responses to other hormones. Protein kinase activity was determined in rat liver homogenates and subcel... | 182,492 | [
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Multifunctional enzyme, bisphosphoglyceromutase/2,3-bisphosphoglycerate phosphatase/phosphoglyceromutase, from human erythrocytes. Evidence for a common active site. | Bisphosphoglyceromutase and 2,3-bisphosphoglycerate phosphatase activities responsible for 2,3-bisphosphoglycerate metabolsim in human red cells are displayed by the same enzyme protein which has phosphoglyceromutase activity [Sasaki, R., et al. (1975) Eur J. Biochem. 50, 581-593]. This enzyme was subjected to chemical... | 182,493 | [
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Electron microscopic characterization of lipoproteins from patients with familial type III hyperlipoproteinaemia. | The lipoproteins of very low density, low density and intermediate density were isolated by zonal ultracentrifugation from the plasma of subjects with familial type III hyperlipoproteinaemia and studied by electron microscopy. Each of these lipoproteins exhibited a spherical shape when free-standing. The very low densi... | 182,502 | [
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The potentiating effects of 4-aminopyridine on adrenergic transmission in the rabbit vas deferens. | The effects of 4-aminipyridine on adrenergic transmission in rabbit vas deferens were investigated. 10(-5)-10(-3) M 4-aminopyridine markedly potentiated the sustained, secondary contractile response to transmural stimulation and significantly increased the amount of (+/-)-|3H]-metaraminol released at 5 Hz, but had litt... | 182,508 | [
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Quantitative studies of intracellular postsynaptic potentials in the lateral geniculate nucleus of the cat with respect to optic tract stimulus response latencies. | LGN cells were intracellularly recorded with glass micropipettes. Electrical stimuli of different amplitude and frequency were applied to the optic tract close to the optic chiasm. The cells were classified according to stimulus response latencies of action potentials as belonging to class I (1.0-16 msec) Or class II (... | 182,514 | [
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The effect of combined chronic hypoxia and N-ethyl-N-nitrosourea on the carotid bodies of rats. | We measured the carotid body volume of rats treated with chronic hypoxia alone and chronic hypoxia together with a single neonatal injection of N-ethyl-N-nitrosourea (10 mg/kg). All the animals so treated showed enlargement of their carotid bodies, but no carotid body chemodectomas occurred. | 182,522 | [
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Intermediary metabolism of adipose tissue. | Metabolism of ruminant adipocytes involves the synthesis and mobilization of lipids. Rates of lipid synthesis from the uptake of preformed fatty acids (via lipoprotein lipase) and de novo synthesis of fatty acids are related to the energy balance. Acetate is the major carbon source for fatty acid synthesis with NADPH o... | 182,555 | [
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Similarity of responses of cultured Sertoli cells to cholera toxin and FSH. | The effects of cholera toxin on the responses of cultured Sertoli cells were compared with those elicited by follicle-stimulating hormone (FSH), and N6O2'-dibutyryl-3',5'-cyclic AMP (bu2cAMP). Addition of FSH or cholera toxin increased cAMP levels. Subsequently there was greater rates of conversion of testosterone to 1... | 182,580 | [
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Vaccination by the non-parenteral route of virus disease in the veterinary field. | After a brief reference to the importance of the non-parenteral route of vaccination of domestic animals in general, the author deals, for each animal species separately, with the most important vaccines utilised by this method of administration. On the basis of bibliographical data, he describes the history of this us... | 182,589 | [
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Effectiveness of orally administered Bordetella pertussis vaccine in mice. | Oral administration of killed Bordetella pertussis organisms to mice results in increased resistance to an intracerebral infection with virulent B. pertussis cells. The rate of survival is dependent on the dose of antigen. But besides specific systemic immunity, which is persistent over a long period, also transient n... | 182,602 | [
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Stimulatory and inhibitory effects of cyclic AMP on pancreatic glucagon release from monolayer cultures and the controlling role of calcium. | When glucagon release from monolayer cultures of newborn rat pancreas was measured over four hours in media containing 2.5 mM Ca++, a significant cyclic AMP-related inhibition of release was observed. This was noted whether intracellular cyclic AMP levels were raised by the addition of exogenous cyclic AMP or dibutyryl... | 182,608 | [
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[Genetics and phenogenetics of the hormonal characteristics of animals. II. Changes in the reactivity of the pituitary-adrenal system and influence of the sex glands in selection of silver-black foxes by behavior]. | Seasonal changes in the reactivity of adrenal cortex to ACTH and of the pituitary-adrenal system to psychic stress in intact and castrated domesticated (tame) and non-domesticated (non-tame) silver foxes of both sexes were studied. It is demonstrated that in tame foxes there are differences among the intact and castrat... | 182,617 | [
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Influence of the assay conditions on the lipolytic potency in vitro of different adrenocorticotrophins. | The lipolytic activity of ACTH-(1-39) and ACTH-(1-24) in vitro has been compared on a molar basis in assays performed with both adipose-tissue slices and isolated fat cells. In the tissue-slice assay ACTH-(1-24) displayed 29% of the potency of ACTH-(1-39), whereas in the isolated-cell assay, ACTH-(1-24) was 3.9 times m... | 182,630 | [
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Isolated corticotrophin-deficiency found through alcohol-induced hypoglycemic coma. | A case of hypoglycemic coma after alcohol ingestion was observed in a chronic alcoholic. Upon close examination isolated corticotrophin-deficiency was found. It is suggested that ethanol-induced hypoglycemia may be consistent with dysfunction of mitochondria in hepatic cells and that there may be disorder of the hypoth... | 182,631 | [
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Purification and characterization of N-acetylneuraminate lyase from Clostridium perfringens. | Clostridium perfringens cells were cultivated on a large scale using an automatic system. 2) N-Acetylneuraminate lyase, which is a cytosolic enzyme, was liberated from the bacteria by cell lysis using lysozyme in hypotonic solution. The enzyme was purified 770-fold by precepitation with ammonium sulfate, filtration on ... | 182,637 | [
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Inflammatory cells in solid murine neoplasms. I. Tumor disaggregation and identification of constituent inflammatory cells. | Mechanical and enzymatic methods of disaggregating tumors were studied with the goals of (1) minimizing cell losses while (2) maintaining functional and surface membrane markers needed to objectively identify inflammatory cells (IC)1 in resultant suspensions. Application of the principles and methods described makes ac... | 182,647 | [
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Manganese requirement of phosphoglycerate phosphomutase and its consequences for growth and sporulation of Bacillus subtilis. | In the absence of manganese, rapidly metabolizable carbohydrates such as glucose or glycerol are not completely metabolized by Bacillus subtilis growing in a nutrient sporulation medium: 3-phosphoglyceric acid (3PGA) accumulates inside the cells, growth stops at a low cell titer, and normal sporulation remains suppress... | 182,667 | [
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Electron microscope study of sporulation and parasporal crystal formation in Bacillus thuringiensis. | A comprehensive ultrastructural analysis of sporulation and parasporal crystal development is described for Bacillus thuringiensis. The insecticidal crystal of B. thuringiensis is initiated at the start of engulfment and is nearly complete by the time the exosporium forms. The crystal and a heretofore unobserved ovoid ... | 182,671 | [
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Hypoxanthine transport by cultured Chinese hamster lung fibroblasts. | The uptake of hypoxanthine by Chinese hamster lung fibroblasts grown in tissue culture was studied in wild type clones and 8-azaguanine-resistant mutant clones devoid of hypoxanthine-guanine phosphoribosyltransferase. Wild type fibroblasts rapidly accumulate [3H]hypoxanthine from the medium and over 80% of the intracel... | 182,679 | [
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Purification and characterization of the carrier protein for juvenile hormone from the hemolymph of the tobacco hornworm Manduca sexta Johannson (Lepidoptera: Sphingidae). | The larval hemolymph of the tobacco hornworm, Manduca sexta, contains a carrier protein that binds specifically and with high affinity the juvenile hormone, an important regulator of insect development. This protein serves to transport the hormone and to protect it from the action of degradative enzymes during early la... | 182,689 | [
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Estrone and estradiol in patients with cirrhosis of the liver: effects of ACTH and dexamethasone. | To study the influence of the adrenal gland on plasma estrogen levels in male patients with hepatic cirrhosis, estrone and estradiol were measured under a variety of experimental conditions. Compared to controls, estradiol levels were moderately elevated by 26% (P is less than 0.05) in patients with hepatic cirrhosis (... | 182,710 | [
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Plaque reduction neutralization test for human cytomegalovirus based upon enhanced uptake of neutral red by virus-infected cells. | Foci of cells infected with human cytomegalovirus were noted to stain more intensely than uninfected cells with neutral red, and this provided the basis for development of a plaque assay and plaque reduction neutralization test for cytomegalovirus. Plaques demonstrable by neutral red staining could be counted at 8 days... | 182,716 | [
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... |
Male pseudohermaphroditism presumably due to target organ unresponsiveness to androgens. Deficient 5alpha-dihydrotestosterone binding in cultured skin fibroblasts. | Maximum specific 5alpha-dihydrotestosterone (DHT) binding activity (Bmax) had been measured in intact confluent monolayers representing fibroblast strains derived form nongenital and genital (labium majus) skin of normal individuals and of 11 patients fulfilling the clinicogenetic criteria of complete testicular femini... | 182,718 | [
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... |
Direct stimulation of bone resorption by thyroid hormones. | Although hypercalcemia, osteoporosis, and increased bone turnover are associated with thyrotoxicosis, no direct effects of thyroid hormones on bone metabolism have been reported previously in organ culture. We have now demonstrated that prolonged treatment with thyroxine (T4) or triiodothyronine (T3) can directly incre... | 182,721 | [
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0.383424,
-0.4140132... |
A new enzymatic method for the determination of free and conjugated glucuronic acid. | A new method is reported for the quantitative determination of glucuronic and galacturonic acid, which is based on spectrophotometric measurement of NADH. The NAD-linked oxidation of the uronic acids to the corresponding dicarboxylic acids is measured in the presence of uronic acid dehydrogenase. This enzyme was isolat... | 182,902 | [
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Nonlocal interactions in the photoreceptor transduction process. | We have recently demonstated the dissection of the transduction process in the barnacle photoreceptor into antagonistic "excitor" and "inhibitor" processes. We now show that (a) the interaction between the two processes proceeds even when they are induced in different pigment molecules; (b) the excitor process appears ... | 182,904 | [
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Metabolism of L-rhamnose in Arthrobacter pyridinolis. | In Arthrobacter pyridinolis, a respiration-coupled transport system for L-rhamnose caused accumulation of free L-rhamnose, while a phosphoenolpyruvate: L-rhamnose phosphotransferase system caused accumulation of L-rhamnose I-phosphate (Levinson & Krulwich, 1974). The pathways for subsequent metabolism of L-rhamnose... | 182,906 | [
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Evaluation of a walking-donor blood transfusion program in an intensive care nursery. | A prospective study was carried out to identify the immediate and long-range advantages and disadvantages of a walking-donor transfusion program for an intensive care newborn nursery. The effect of heparin on coagulation of blood was evaluated and found to be minimal. There was no evidence of transmission of HBSAg. The... | 182,947 | [
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0.31092... |
Treatment of heterozygous type II hyperlipidemia by partial ileal bypass in a pediatric population. | Nine patients underwent partial ileal bypass as management for heterozygous type II hyperlipidemia. The average age of this group was 12.5 yr. Follow-up has ranged from 1 to 6 yr. The growth and development of these children proceeded normally. The overall average serum cholesterol reduction was 33% when compared to t... | 182,951 | [
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... |
Synaptic depression related to presynaptic axon conduction block. | 1. The depression of synaptic transmission, which occurs during prolonged repetitive activation, was examined in the opener muscle of the crayfish walking leg. 2. Excitatory post-synaptic potentials (e.p.s.p.s) initially facilitated but then declined to low amplitudes after about 4000 stimulus pulses had been delivered... | 182,964 | [
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0.1563512,
0.12515... |
Statistical fluctuations in charge transfer at Ia synapses on spinal motoneurones. | 1. Net inward charge is calculated for unitary Ia e.p.s.p.s. evoked in spinal motoneurones. Fluctuations in this charge are used to describe the fluctuations in transmission at the Ia synapse. 2. The statistical details of variation in transmission at Ia synapses are largely obscured by noise, arising from spontaneous ... | 182,967 | [
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0.07913202,
0.2428048... |
Blood pressure and sleep in the rat in normotension and in neurogenic hypertension. | 1. Blood pressure was recorded in normotensive rats (114 +/- 2 mmHg) and in those made hypertensive by baroreceptor denervation (135 +/- 4 mmHg) during natural sleep. The different states of the wakefulness-sleep cycle were identified by analysis of the frontal electrocorticogram, the cervical electromyogram and by beh... | 182,970 | [
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0.02797607,
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[The ACTH of the pituitary pars intermedia]. | The present investigation suggests that the intermediate lobe contains corticotrophic cells that are morphologically similar to those of the adenohypophysis. It can also be concluded that the ACTH molecules extracted from the intermediate lobe do not differ from those from the adenohypophysis. The immunocytochemical st... | 182,971 | [
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Nucleotide sequence that binds primer for DNA synthesis to the avian sarcoma virus genome. | Initiation of transcription from the genome of avian sarcoma virus by RNA-directed DNA polymerase in vitro requires tRNAtrp as a primer. The tRNA is bound to the viral genome by a sequence of 16 contiguous nucleotides (U-C-A-C-G-U-C-G-G-G-G-U-C-A-C-Cp), beginning with the penultimate base at the 3' terminus of the prim... | 183,013 | [
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DNA-binding proteins induced by herpes simplex virus type 2 in HEp-2 cells. | Affinity chromatography on single-stranded and double-stranded DNA-cellulose indicates that 12 proteins previously identified from herpes simplex virus type 2-infected cells, ranging in molecular weight from 28 X 10(3) to 186 X 10(3), bind to DNA-cellulose. The DNA-binding proteins found in infected cells differed in r... | 183,021 | [
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0.02807659,
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... |
Hepatic abscess. Diagnosis in the adult by total body opacification. | Two adults had the hypovascular nature of their hepatic abscesses ascertained by total body opacification. In one, total body opacification identified the hypovascular nature of the lesion, facilitating its differentiation from vascular hepatoma. In the other, the clinical diagnosis was acute cholecystitis with empyema... | 183,028 | [
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0.07271092,
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Redistribution of immunoglobulin receptors on human neutrophils and its relationship to the release of lysosomal enzymes;. | Release of the lysosomal enzyme beta-glucuronidase from human neutrophils was induced by IgG or its Fc fragment, aggregated by immune precipitation or by coating on latex particles. Such release was inhibited when the cells were preincubated with free IgG or Fc fragments; F(ab')2 fragments were ineffective in both indu... | 183,051 | [
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... |
Treatment of senile dementia and cerebellar disorders with phthalazinol. Cyclic AMP-increasing agent, phthalazinol, in therapeutic trials in hitherto incurable morbid conditions (I). | Three patients suffering from presenile dementia and two patients suffering from senile dementia were treated with phthalazinol. A limited but definite improvement in attentiveness, vocabulary reception and psychologic attainment and also a limited but definite improvement in range of motion, gait and endurance were no... | 183,066 | [
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0.1458045,
0.376106,
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... |
Declining mortality and improving survival from Wilms' tumor. | Mortality from kidney cancer in the United States declined dramatically over the period 1940-1969. This trend was nearly proportional to the increases in survival for 644 U.S. children reported to the End Results Group, National Cancer Institute. The improvements in survival occurred for all stages of disease and appea... | 183,091 | [
-0.1835074,
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0.1730661,
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0... |
Infection of UV-irradiated xeroderma pigmentosum fibroblasts by herpes simplex virus: study of capacity and Weigle reactivation. | The capacity of monolayers of both normal human and xeroderma pigmentosum (XP) filbroblasts to support plaque formation by herpes simplex virus was decreased when the monolayers were ultraviolet (UV) irradiated and infected with virus. Fibroblasts of XP complementation groups A, B, and D were sensitive to UV, being 4-6... | 183,109 | [
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... |
Inactivation and mutation of coliphage T4 by aliphatic nitrosamides and methanesulphonates: in vitro recovery of infectivity of T4 inactivated by isopropyl methanesulphonate. | The inactivation and mutation (to r phenotype) of extracellular coliphage T4 wild-type by the monofunctional alkylating agents N-methyl- and N-ethyl-N-nitrosourea and isopropyl methanesulphonate were investigated. The rate and extent of change in phage infectivity observed during the post-treatment period were found to... | 183,110 | [
-0.2342137,
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0.383383,
-0.07939885... |
Adrenocortical responses of rats to acute hypoxic and hypercapnic stresses after treatment with aminergic agents. | Monoaminergic influences on the regulation of the hypothalamo-hypophyseal-adrenocortical (HHA) system during acute stresses (hypoxia and hypercapnia) were investigated in male rats. Plasma corticosterone levels were used to assess HHA activity, and the alterations in monoaminergic activity were induced by pretreating t... | 183,164 | [
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Sleep EEG and motor activity as indicators in affective states. | This report reviews a number of studies which support our current classification schema for affective disorders. This classification differentiates between an anxious-hyperactive type and an anergic-hypoactive type which are then further subdivided into primary and secondary affective disorders. While the motor and act... | 183,166 | [
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"Giant axonal neuropathy" caused by industrial chemicals: neurofilamentous axonal masses in man. | Symmetrical polyneuropathy developed in two patients after they had been in contact with acrylamide and methyl n-butyl ketone, respectively. In sural nerve biopsy material from both patients, electron microscopy showed frequent focal axonal swellings containing masses of neurofilaments. Some axons undergoing axonal deg... | 183,168 | [
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... |
Comprehensive care of the ileostomy patient. | Comprehensive care of the person with an ileostomy is an integral part of professional nursing. It is the responsibility of professional nurses to be knowledgeable and skilled in ileostomy patient care. This article has presented basic issues to be considered in facilitating the rehabilitation of the person with an ile... | 183,187 | [
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... |
Effect of Indomethacin on cyclic AMP phosphodiesterase activity in myometrium from pregnant rhesus monkeys. | Our results indicate that indomethacin inhibits cyclic AMP phosphodiesterase in the myometrium of the pregnant rhesus monkey under in vitro as well as in vivo conditions. Kinetic data on extracts of myometrium from pregnant rhesus monkeys indicated two cyclic AMP phosphodiesterase activities. The apparent Km value for ... | 183,237 | [
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0.3323596,
0.1517427,
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0.178... |
Progesterone binding to hen oviduct genome: specific versus nonspecific binding. | Data are presented to explain discrepancies in the literature involving the in vitro binding of steroid receptor complexes to isolated nuclei and chromatin. The type of binding in vitro of the progesterone-receptor complex to nuclei, chromatin, or DNA of hen organs is largely determined by the ionic strength of the med... | 183,267 | [
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Studies of the thromboplastic effect of human plasma lipoproteins. | Human plasma lipoprotein fractions were prepared by flotation in the ultracentrifuge. Addition of these fractions to platelet-rich, platelet-poor and platelet-free plasma affected the partial thromboplastin and Stypven clotting times to various degrees. Addtion of high density lipoprotein (HDL) to platelet-poor and pla... | 183,306 | [
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-... |
Ribonucleases and neoplasia. | Biochemical data provide good evidence of a lack of acid and alkaline RNase activities in ascites tumour cells. Analyses of whole solid tumours appear of doubtful value, but fractionation studies reveal RNase deficiencies in mitochondrial fractions whereas inconsistent results are reported for microsomal fractions. Nuc... | 183,316 | [
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-0.2632334,
0.3387405,
0.2894596,
-0.006532281,
-0.2177705,
-0.2699248,... |
[Study of certain components of the kinin system in acute purulent peritonitis]. | Under study was the kinetics of changes in the kinin content, the activity of kininase and blood proteolytic activity in acute purulent peritonitis in 63 patients. The kinin activity was judged indirectly by the kinin level in blood. The results of the study indicated that in acute purulent peritonitis the kinin concen... | 183,334 | [
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... |
[Biochemistry of benign-symmetrical lipomatosis (adenolipomatosis Launois-Bensaude, Madelung's disease)]. | 1. Total lipids, total cholesterol, cholesterol esters, phospholipids, triglycerides and free fatty acids as well as the fatty acids profiles of the different lipid classes were determined in serum, lipomatous and normal adipose tissue. Triglycerides were elevated in patient L's serum. The distribution of serum lipopro... | 183,373 | [
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0.2138337,
0.4564308,
0.2932056,
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... |
[Participation of gonads in pulmonary silicosis]. | A survey is given on the participation of endocrine glands in the pulmonary silicosis. At the same time a new clinical and experimental contribution to the question of the appearance of a hypogonadotropic hypogonadism is given. The frequency of this hypogonadism increases with the severity of the pulmonary silicosis. T... | 183,394 | [
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0.01291229,
0.1956525,
0.4015527,
0.020002... |
Local and systemic opsonic adherent, hemagglutinating and rosette forming activity in mice induced by respiratory immunization with sheep red blood cells. | The humoral response in mice after intranasal (IN) instillation of sheep red blood cells (SRBC) was compared to that produced by intraperitoneal route of immunization. Study of opsonic adherent (passive indirect cytophilic) and hemagglutinating antibody levels in serum and bronchial washings after repeated challenge wi... | 183,401 | [
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0.1022087,
0.08580752,
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[Hidradenoma of the skin. Synoptic reveiw of syringeal hidradenoma, eccrine epithelioma and eccrine basalioma (author's transl)]. | An ulcerating and sclerosing skin tumour on the temporal forehead region is described. Histologically the tumour is composed of different structures as cystic hidradenoma, syringoma, ductal hidradenoma and sclerres as cystic hidradenoma, syringoma, ductal hidradenoma and sclerosing basalioma arranged in layers. The tum... | 183,411 | [
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0.3998089,
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0.4264265,
0.03661498,
0.1599457,
0.35... |
[Discharge of myeloperoxidase from neutrophils during bacterial sorption]. | A study was made of conditions and dynamics of discharge of myeloperoxidase (MPO) from rabbit neutrophils in case of encounter with staphylococci. The discharge began not later than 9--12 minutes after the administration of Staph. aureus into the neutrophil suspension, i. e. as early as the stage of bacterial sorption,... | 183,431 | [
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0.3627875,
0.283574,
0.3075304,
0.09140269,... |
Demonstration of a pituitary gonadotrophin hormone activity in the male foetal mouse. | The testosterone production by 18-days-old foetal mouse testis was measured in an organ culture system, by RIA in the culture medium. This production was time-dependent, and could be stimulated by ovine LH and age-matched foetal pituitary. The gonadotrophin activity derived from foetal pituitary appeared to be released... | 183,442 | [
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0.1042932,
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-... |
Clofibrate in type II hyperlipoproteinemia. | As a part of a double-blind randomized study, the safety and the lipid- and uric acid-lowering effect of clofibrate have been evaluated in 28 patients with type II hyperlipoproteinemia (HLP). A highly significant reduction of serum cholesterol occurred in type IIa and of serum triglyceride and choelsterol in type IIb H... | 183,462 | [
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0.3620804,
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... |
Effects of ethanol on bile acid and cholesterol metabolism. | The effects of ethanol on plasma lipid and lipoprotein concentrations and on the fecal excretion of neutral sterols and bile acids were studied in three patients with ethanol-induced hyperlipidemia and in four normolipidemic men. In the three patients, plasma triglyceride and cholesterol concentrations were much higher... | 183,492 | [
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0.1574242,
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0.4370867,
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... |
Pseudohomozygous and pseudoheterozygous type II hyperlipoproteinemia. | A 4-year-old boy had typical features of homozygous type II hyperlipoproteinemia with planar xanthomas, a plasma cholesterol level greater than 600 mg/dl, and an estimated beta-lipoprotein cholesterol concentration greater than 500 mg/dl. Both he and his sister, who had the biochemical features of the heterozygous stat... | 183,495 | [
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0.2719433,
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Neutralization of a transmissible gastroenteritis virus of swine by colostral antibodies elicited by intestine and cell culture-propagated virus. | Cross-protection studies of gilts exposed to 4 transmissible gastroenteritis viruses--Ilinois (field strain), Miller-3, Miller low passage (M-LP), and Miller high passage (M-HP) tissue culture-adapted--indicated that only the gilt vaccinated with Illinois strain was protected, along with its newborn pigs, against chall... | 183,573 | [
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0.1957058,
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0.2241444,
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... |
BCG immunoprophylaxis of recurrent herpes progenitalis. | Thirty-eight patients with severe, recurrent herpes progenitalis were treated by immunoprophylaxis with repeated BCG inoculations. Results of the study demonstrated no significant prophylactic benefit of BCG when contrasted to other homologous or heterologous antigens or to control patients receiving placebos. Caution ... | 183,605 | [
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0.189164,
-0.0257860... |
Rapid eye movement sleep density. An objective indicator in severe medical-depressive syndromes. | The electroencephalographic sleep patterns of 12 patients with a final diagnosis of primary depression and those of 12 patients admitted to the Clinical Research Unit with this diagnosis, but subsequently also found to be suffering from severe medical disease, were compared. Patients with depression concurrent with sev... | 183,622 | [
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0.3524106,
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0.04034487,
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0.07286203,
... |
Purification and characterization of equine infectious anemia virus. | EIA virus was purified from equine fetal kidney cell cultures by PEG-precipitation, two sucrose-gradient sedimentations (5-30 per cent) and (25 to 60 per cent) centrifugation, using the immunodiffusion test to follow the procedure. Purified EIA virus had a density (20 degrees C) of 1.162 and a sedimentation constant of... | 183,628 | [
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0.1756092,
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0.2553942,
-0.01650316,
0.09612755,
0.02096... |
Quantitative studies on adsorption, elution, and haemagglutination of vesicular stomatitis virus. | Radioactively-labelled VSV, both Indiana and New Jersey serotypes, were rapidly and efficiently adsorbed onto goose erythrocytes, but only within a narrow range of pH and at low temperatures. Under optimal conditions for adsorption, both infectivity and haemagglutinating activity of VSV were reduced. A basic difference... | 183,632 | [
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0.1671182,
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... |
[Herpesvirus-induced autoantibodies in animals (author's transl)]. | After immunization with autologous testicle cells which were infected with herpes virus hominis type 1 or 2, histologically homogeneous, eosinophilie PAS-positive substances could be detected in five out of six rabbits, mainly within the interstitium. These substances have been found by immunofluorescence microscopic t... | 183,633 | [
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0.1360634,
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-0.02433962,
... |
Late-infantile neuronal ceroid-lipofuscinosis. An ultrastructural study of lymphocyte inclusions. | Ultrastructural study of peripheral blood from two patients with late-infantile neuronal ceroid-lipofuscinosis with curvilinear bodies, demonstrated in brain biopsies revealed curvilinear bodies in lymphocytes. These findings indicate that ultrastructural investigation of circulating lymphocytes may be useful in the di... | 183,637 | [
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0.5602656,
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-... |
[Definition and differential diagnosis of chromophobe pituitary adenomas: light and electron microscopic studies]. | Chromophobe adenomas have been defined by the absence of secretory granules in them. But this definition has become doubtful since a granulation could be electron microscopically demonstrated. Hence we studied a collection of more than 100 surgically removed pituitary adenomas in order to find precise morphological cri... | 183,657 | [
0.2264854,
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0.199684,
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0... |
Immunogenetic study on the polymorphism of serum alpha2-lipoproteins in mink. I. Identification and genetic control of five Lpm allotypes. | Five allotypes, Lpm 1, Lpm 2, Lpm 3, Lpm 4, and Lpm 5, were detected by isoimmunization in mink sera. Immunoelectrophoresis, preparative ultracentrifugation, and histochemical tests for lipids and esterase permitted reference of these alloantigenic markers to a very high density alpha2-lipoprotein. Based on population ... | 183,738 | [
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0.2526393,
0.1681036,
0.1111996,
0.4346835,
-0.282635... |
Kinetics and reaction mechanism of yeast alcohol dehydrogenase with long-chain primary alcohols. | Kinetic studies of yeast alcohol dehydrogenase with NAD+ and ethanol, hexanol or decanol as substrates invariably result in non-linear Lineweaver-Burk plots if the alcohol is the variable substrate. The kinetic coefficients determined from secondary plots are consistent with an 'equilibrium random-order' mechanism for ... | 183,740 | [
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0.1473065,
0.2282193,
0.1375121,
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0.11210... |
Atilipidemic drugs. Part 5: Evaluation of the hypolipidemic effect of LF 178 in 191 patients affected by the atherogenic form of endogenous hyperlipoproteinemia (types IIa, IIb and IV). | The effect of isopropyl-[4'-(p-chlorobenzoyl)-2-phenoxy-2-methyl]-propionate (LF 178; procetofene; Lipanthyl), a new hypolipidemic agent, has been evaluated in 191 patients affected by endogenous hyperlipoproteinemia (IIa, IIb and IV). Data were collected from patients on active drug trial from 1 to 18 months. The dail... | 183,788 | [
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0.374474,
0.1024423,
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0.3412476,
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0.3790123,
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... |
Annular lipids determine the ATPase activity of a calcium transport protein complexed with dipalmitoyllecithin. | Pure complexes of dipalmitoyllecithin (DPL, 16:0) which Ca2+, Mg2+ dependent ATPase from sarcoplasmic reticulum are unusual in retaining significant ATPase activity down to about 30 degrees C, well below the transition temperature of the pure lipid at 41 degrees C. A minimum of about 35 lipid molecules per ATPase is re... | 183,811 | [
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0.127776,
0.2080711,
0.1303815,
0.06998426,
0... |
The relationship between environmental temperature, cell growth and the fluidity and physical state of the membrane lipids in Bacillus stearothermophilus. | A definite and characteristic relationship exists between growth temperature, fatty acid composition and the fluidity and physical state of the membrane lipids in wild type Bacillus stearothermophilus. As the environmental temperature is increased, the proportion of saturated fatty acids found in the membrane lipids is... | 183,821 | [
0.1695559,
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0.101083,
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0.05601853,
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... |
Stimulation of the biosynthesis of membrane glycoproteins from Zajdela ascites hepatoma cells by Robinia lectin. | Membrane glycoprotein biosynthesis of ascites hepatoma cells is followed by [14C]glucosamine and [3H]leucine incorporation into cells in culture. The rate of incorporation is strongly increased by the addition of Robinia lectin in culture medium. Labeled glycoproteins are released from lectin stimulated and non-stimula... | 183,823 | [
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0.2924478,
0.03593788,
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0... |
REM latency: a psychobiologic marker for primary depressive disease. | Previous investigations have indicated that one of the most consistent EEG sleep findings in depressive patients has been a shortened REM latency. On the basis of these studies, we have concluded that with the exception of drug withdrawal states (such as CNS depressant or amphetamine withdrawal and narcolepsy) shortene... | 183,839 | [
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0.2315362,
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-0.1560785,
-0.... |
Isolation and carbohydrate composition of glycopeptides of human apo low-density lipoprotein from normal and type II hyperlipoproteinemic subjects. | Glycopeptides were prepared from the delipidized protein of low-density lipoprotein (LDL, d=1.019-1.063) of three normal and three familial heterozygous type II hyperlipoproteinemic (HLP) subjects. The glycopeptides of all subjects were resolved into three groups by gel filtration on Bio-Gel P6 following papain (EC 3.4... | 183,881 | [
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0.09997895,
0.06139206,
0.158804,
0.4224314,
-0.3913617,
0.... |
Concerning the independence of the basis of hypertension due to ACTH or renovascular constriction. | Administration of ACTH to four sheep with chronic renovascular hypertension resulted in an increase in blood pressure which was at least as high as that described in normotensive sheep and could be completely accounted for by an increase in cardiac output. | 183,887 | [
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-0.06279939,
... |
The number of superhelical turns in native virion SV40 DNA and minicol DNA determined by the band counting method. | By a method of overlapping the results obtained after agarose gel electrophoresis under two different sets of conditions, it has become possible to determine the number of superhelical turns in a given DNA by counting the bands present after partially relaxing the DNA (Keller and Wendel, 1974) with highly purified nick... | 183,892 | [
0.09031755,
0.007251085,
-0.4478438,
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0.2251088,
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0.216885,
0.3996456,
0.1260124,
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0.1900735,
0.4126636,
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0.1727163,
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0.03987857,
0.03794912,
0.4429851,
0.4702503,
-0.1800719,
-0.01303766,
0... |
5' terminal nucleotide sequences of the messenger RNA's of Dictyostelium discoideum. | As in the mRNA from all other eucaryotic cells examined, the 5' nucleotide in messenger RNA from Dictyostelium discoideum is linked by a 5'-5' triphosphate bridge to the unusual nucleoside 7-methyl guanosine. In mammalian cellular mRNA, the 5' terminal sequences have the general formula m7GpppXmpYp(m), where X and Y ca... | 183,893 | [
-0.4238136,
0.05827839,
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0.06422273,
0.06074236,
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0.02111623,
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0.07059466,
0.3287766,
0.23141,
-0.09541159,... |
Evidence for superoxide-dependent reduction of Fe3+ and its role in enzyme-generated hydroxyl radical formation. | This report describes studies yielding additional evidence that superoxide anion (O2) production by some biological oxidoreductase systems is a potential source of hydroxyl radical production. The phenomenon appears to be an intrinsic property of certain enzyme systems which produce superoxide and H2O2, and can result ... | 183,903 | [
-0.2371876,
0.1102757,
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0.1060429,
0.36917,
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0.2335405,
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0.09055898,
0.415512,
0.2693849,
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-0.1613851,
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0.04255161,
-0.03687389,
0.2742796,
-0.3130906,
... |
Susceptibility of some rodent species to monkeypox virus, and course of the infection. | The authors studied the susceptibility of five species of rodent to monkeypox virus inoculated by various routes and the course of the infection. Reactions varied from complete resistance to lethal generalized infection with rash. Rabbits and white mice appeared to be the most susceptible species and young animals were... | 183,908 | [
0.08529373,
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-0.1454172,
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0.1748746,
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0.2812109,
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0.07151538,
0.02379902,
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-0.337004,
-0.1936234,
0.1467554,
0.2255438,
0.3552141,
-0.02057587,
0.2690509,
-0.09878617,... |
Relationships between myocardial perfusion, myocardial necrosis, and technetium--99m pyrophosphate uptake in dogs subjected to sudden coronary occlusion. | The quantitative relationship between abnormalities seen on technetium-99m pyrophosphate (99mTc-PYP) infarct scintigrams and the size of the myocardial infarction is unclear. We evaluated two possible determinants of 99mTc-PYP accumulation: myocardial perfusion measured with 7-10 mu microspheres and the extent of necro... | 183,915 | [
-0.3288071,
0.3908064,
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0.03637902,
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0.2719244,
0.2261229,
0.2559089,
0.2765132,
0.1261639,
-0.0472528,
-0... |
[Treatment of essential hypertension with propranolol (author's transl)]. | Effect of long-term administration of propranolol was studied in 90 unselected patients with essential hypertension. At a dose of 180 and 360 mg daily it dropped the blood pressure to at least 155/95 mm Hg in 31 patients (34.4%). Those who responded to propranolol had lower systolic and diastolic blood pre-treatment pr... | 183,943 | [
-0.2111242,
0.06511027,
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0.2426371,
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0.09072688,
-0.2541252,
0.3722828,
0.1392462,
0.06688023,
-0.1437527,
... |
Effect of cirrhosis on pulmonary fibrogenesis caused by silica dust in rats. | The cirrhosis in male albino rats was produced after repeated subcutaneous injections of carbon tetrachloride, in dosage schedule as described. A fully developed cirrhosis was observed after 150 days. The silicosis in lungs was produced after single intratracheal injection of silica dust of particle size less than 5 mi... | 183,970 | [
0.01946897,
0.1094029,
0.05905496,
0.3127567,
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0.1547047,
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-0.1253398,
0.03432971,
0.2551844,
-0.2219133,
-0.2423903,
0.4673871,
-0.04056405... |
Oxygenation of a dipyrromethene model for bilirubin: formation of a singlet oxygen-like product. | An oxodipyrromethene model compound for bilirubin is found to undergo oxidation to a blue tetrapyrrole and a water-propentdyopent on a silica gel thin layer chromatography plate. The reaction involves ground state oxygen and requires silica gel, although the propentdyopent is an expected product from reaction with sing... | 183,976 | [
-0.2214202,
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0.09003751,
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0.4018547,
0.2279141,
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0.3057247,
-0.09425474,
-0.0695... |
Hormonal studies of uridine utilization in an insect cell line CP-1268 derived from the codling moth Laspeyresia pomonella. | Ecdysterone decreased cellular growth and the incorporation of uridine into RNA following 4 days of hormone exposure. This hormone did not affect uridine incorporation following short-term exposure up to 25 hours. Juvenile hormone and farnesol both significantly decreased uridine uptake and incorporation into RNA; howe... | 184,032 | [
-0.2546301,
-0.3787969,
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0.2338714,
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0.2597423,
0.0648508,
0.250392,
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0.1601197,
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0.2523355,
-0.0372347,
0.01739692,
0.5914266,
-0.2656372,
-0.3276544,
... |
Effect of essential fatty acid deficiency on the lipid composition of the Yoshida ascites hepatoma (AH 130) and of the liver and blood plasma from host and normal rats. | In order to study the response of a poorly differentiated tumor to nutritional manipulation, the Yoshida ascites hepatoma (AH 130) was grown in rats fed an essential fatty acid (EFA)-deficient diet and in rats fed a control diet. Hepatomas, livers, and blood plasma from host rats and normal rats were studied as to the ... | 184,222 | [
-0.1440709,
0.122744,
0.08193108,
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0.2830648,
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0.1447516,
0.2784264,
0.1256984,
0.1249339,
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0.07980636,
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-0.2065894,
0.03719423,
-0.2215112,
0.2467044,
-0.009651651,... |
Effect of an anti-lipoprotein lipase serum on plasma triglyceride removal. | Anti-lipoprotein lipase sera injected intravenously in roosters blocked quantitatively the catabolism of very low density lipoprotein (VLDL) triglyceride. Antibodies were produced in rabbits immunized with highly purified lipoprotein lipase (LPL, glycerol ester hydrolase, E C 3.1.1.3) prepared from chicken adipose tiss... | 184,224 | [
0.2908376,
-0.006229546,
-0.5380819,
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0.06510943,
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0.2452777,
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0.2447007,
0.1708546,
0.1383668,
0.2430514,
0.1820965,
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0.01373521,
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0.3466212,
0.4157408,
0.3309252,
0.1514511,
-0.1487765,
0.0... |
The effect of maternal cytomegalovirus infection on preimplantation development in the mouse. | Mice were inoculated with murine cytomegalovirus at 14 and 7 days before and 1 and 4 days after mating. The effects of maternal infection on early pregnancy were investigated. Inoculation 7 days before and 1 day after mating, i.e. around ovulation and implantation, significantly reduced pregnancy rate. Embryos in these... | 184,279 | [
-0.07209323,
-0.04883064,
-0.3589336,
-0.05080619,
0.2473672,
-0.04676604,
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0.04283486,
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0.01718764,
0.1564426,
0.1634521,
0.4294874,
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-0.2153493,
0.1833326,
-0.1653128,
0.1918298,
0.1765673,
0.06308806,
0.0804027... |
Synthesis and anti-DNA -virus activity of the 5'-monophosphate and the cyclic 3',5'-monophosphate of 9-(beta-D-xylofuranosyl) guanine. | 9-(beta-TD-xylofuranosyl)guanine (xylo-G) was converted chemically to the 9-(beta-D-xylofuranosyl)guanine 5'-monophosphate (xylo-GMP) and 9-(beta-D-xylofuranosyl)guanine cyclic 3',5'-monophosphate (c-xylo-GMP). These compounds were tested against a variety of DNA viruses in tissue culture in parallel with 9-(beta-D-ara... | 184,282 | [
-0.3164296,
-0.009548503,
-0.3681479,
-0.1846007,
0.231968,
-0.1368098,
-0.2319349,
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-0.0963319,
0.07968349,
-0.1869733,
0.2584206,
0.09998961,
0.2671998,
-0.7766908,
0.09996571,
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0.359031,
-0.2827944,
0.3324699,
0.2171315,
-0.09320652,
-0.164369,
... |
Synthesis and biological properties of some spin-labeled 9-aminoacridines. | Five spin-labeled 9-aminoacridines, each bearing either a 4-(2,2,6,6-tetramethyl-1-piperidinyloxy) or a 3-(2,2,5,5-tetramethyl-1-pyrrolidinyloxy) moiety in the 9 position, have been synthesized and assayed for biological activity in three different test systems. Sedimentation velocity measurements indicated that the la... | 184,284 | [
-0.2814673,
0.1054464,
-0.2733939,
-0.003711852,
0.05866636,
0.0009278468,
-0.1503291,
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0.3250096,
0.1047242,
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0.04758654,
0.4485808,
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0.1155955,
-0.8121923,
0.06048845,
-0.6596639,
0.119885,
0.5417702,
-0.01451519,
-0.0931395... |
[Adenyl cyclase activity in the tissues and excretion of cyclic adenosine monophosphate in experimental arteriosclerosis]. | The activity of adenylcyclase in the tissues and the elimination of 3',5'-AMP with urine were studied in rabbits and rats with experimentally induced atherosclerosis. The relationship between the concentration of steroid hormones and the activity of adenylcyclase in the adrenals was studied after varying periods of ath... | 184,339 | [
-0.2553184,
-0.1272935,
-0.2775463,
-0.0313612,
0.2250661,
-0.3427077,
-0.2273952,
0.06919935,
0.03810493,
0.09741238,
0.0316592,
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0.2586476,
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0.06346329,
-0.7009918,
-0.03340075,
-0.10078,
0.4801238,
0.4181461,
-0.01526064,
-0.07905446,... |
A study of the heparin-manganese chloride method for determination of plasma alpha-lipoprotein cholesterol concentration. | To assess the limits of the heparin MnCl2 precipitation method for quantitation of alpha-lipoprotein cholesterol (C-HDL), effects of varying final McCl2 and heparin concentrations were studied, and the precipitation method was compared to preparative ultracentrifugation. In 65 parallel plasma aliquots, C-HDL (X+/-SE) d... | 184,362 | [
-0.05304603,
0.1140093,
-0.2175125,
-0.2544769,
-0.135412,
-0.1125918,
-0.2122469,
0.3977912,
-0.1408849,
0.374066,
-0.1303589,
0.4458302,
0.3708014,
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-0.3694429,
0.0302331,
0.0753434,
-0.2051121,
-0.1185087,
0.4301338,
0.1914126,
-0.2383222,
0.2324428,
0.03... |
Lutropin receptors from male and female tissues: different responses to a lutropin receptor binding inhibitor. | An inhibitor for lutropin receptor site binding (LH-RBI), which strongly inhibited the binding of 125I-labeled ovine lutropin ([125I]oLH) to ovarian LH receptors, did not inhibit the [125I]oLH binding to testicular LH receptors. Preincubation of the LH-RBI with [125I]oLH did not affect the binding of preincubated ]125I... | 184,473 | [
0.2773659,
-0.08675788,
0.009671379,
-0.3202317,
0.3390286,
-0.06194399,
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0.08688807,
0.08327007,
0.1446375,
0.5320767,
0.01632366,
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0.122219,
0.2437817,
-0.02870779,
0.2975651,
0.3870366,
-0.100597,
... |
Dust exposure in Finnish foundries. | Dust measurements were made in 51 iron, 9 steel, and 8 nonferrous foundries, at which 4,316 foundrymen were working. The sampling lasted at least two entire shifts or work days continuously during various operations in each foundry. The dust samples were collected at fixed sites or in the breathing zones of the workers... | 184,524 | [
-0.0765032,
0.2072424,
0.1755182,
0.1241337,
-0.1111239,
-0.2026544,
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0.02554007,
0.1454895,
0.5430828,
0.2314484,
-0.5300651,
0.06432072,
-0.2815932,
-0.3678918,
0.1753063,
-0.2046626,
-0.380959,
0.1181395,
0.09159768,
0.1650568,
0.3548229,
0.1143795,
0.2908... |
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