title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
|---|---|---|---|
[Isolation of reoviruses from mink]. | In this first report of the isolation of reovirus from mink, isolates were obtained from 18 to 26 young mink with viral enteritis, by using cultures of cat kidney cells. The isolated also produced cytopathic changes in cell cultures of mink kidney, dog kidney, piglet kidney, calf kidney, bovine embryonic kidney and cal... | 180,927 | [
0.003111142,
0.05274323,
-0.005254612,
0.2693867,
0.3382878,
-0.1377448,
0.01492923,
0.1781608,
-0.2816928,
-0.1359058,
0.3848679,
-0.1010964,
-0.04510996,
-0.004686921,
-0.4597617,
-0.1262858,
-0.2793677,
0.3876263,
0.2268679,
0.1840742,
-0.0006636814,
0.2130619,
-0.3340... |
Histocompatibility types and viral antibodies. | Serum neutralizing (Nt) antibodies to herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), and histocompatibility (HL-A) types, were determined in multiple sclerosis (MS) patients and in control subjects. Titers of Nt antibodies to HSV-1 and to HSV-2 were increased among subjects bearing HL-A3 or HL-A7 or both, whet... | 180,933 | [
0.09841692,
-0.03786215,
-0.1756092,
-0.1993598,
0.009807663,
-0.2124705,
-0.1102517,
0.1028701,
-0.1866907,
0.03689004,
0.1258536,
0.08853088,
0.3457465,
-0.006212103,
0.03735013,
-0.5349652,
-0.2562407,
0.07639094,
0.2588583,
-0.1312004,
0.1728227,
0.07960675,
-0.149415... |
Thalidomide anomalies of the ear. | Eighteen 12- to 16-year-old patients with thalidomide embryopathy were examined otologically and neurotologically to clarify both morphological and functional ear anomalies. Ear anomalies were found in the external, middle, and inner ears. However, the inner ear, especially the vestibular portion of the labyrinth, was ... | 180,947 | [
-0.05943052,
-0.04686063,
-0.008212906,
-0.09791125,
0.2408571,
-0.3528863,
-0.3109997,
0.004292559,
0.100372,
-0.0607134,
0.3252745,
0.2235111,
-0.170543,
-0.1514659,
-0.00002245333,
0.2508314,
-0.4172065,
0.2988514,
-0.2824417,
-0.06336965,
0.2256619,
0.01489534,
-0.013... |
The role of calcium binding protein in the mechanism of action of cholecalciferol (vitamin D3). | A role has been sought for the calcium binding protein (CaBP) which is synthesised de novo after giving cholecalciferol (CC, vitamin D3) to rachitic chicks. After homogenation of mucosal cells in sucrose media, the CaBP was found in the 78,000 X g supernatant. Therefore, the CaBP is either present in the cytoplasm or i... | 180,950 | [
-0.438419,
-0.2858328,
-0.1048382,
-0.1460467,
0.4246555,
-0.3023553,
-0.1165074,
0.1676088,
0.1784943,
0.1355857,
0.2245832,
0.008590071,
-0.1740379,
0.01249277,
-0.4662372,
0.2157401,
-0.8473017,
-0.2490377,
0.02850594,
0.1065553,
0.1850724,
0.3653396,
-0.08391126,
-0... |
Isolation and characterisation of bovine herpesvirus mammillitis virus and its pathogenicity for cattle. | Ten viruses isolated from swabs and vesicular fluid collected from the teats of dairy cattle on 4 properties in Northern Victoria were identified as bovine herpes mammillitis (BHM) viruses by their physico-chemical and morphological properties and serological relationship to each other and a Scottish Strain of BHM viru... | 180,955 | [
-0.1788693,
-0.1139399,
-0.07152008,
-0.3337231,
-0.2496479,
-0.2379077,
-0.139642,
0.06544759,
0.1586146,
-0.1774238,
0.1729469,
-0.344692,
0.05734308,
0.2233495,
-0.2359743,
-0.05461916,
-0.0374786,
-0.1053518,
0.270432,
-0.07240292,
0.009762307,
0.3790362,
-0.0659367,
... |
Change in the mixed function oxidase system of liver microsomes in rats treated with 3'-methyl-4-dimethylaminoazobenzene. | The mixed function oxidase systems of plasma membranes, the Golgi apparatus, and smooth and rough endoplasmic reticula of the livers of rats fed on a standard diet containing 0.06% (w/w) 3'-methyl-4-dimethylaminoazobenzene were investigated. The components and activities of the mixed function oxidase systems of the smo... | 180,967 | [
-0.1049519,
0.08779649,
0.036981,
0.3318059,
0.125343,
-0.3797482,
0.1160775,
-0.01128023,
-0.0212492,
0.308806,
0.1457173,
-0.080578,
0.1512825,
0.4068955,
-0.6410288,
0.144688,
-0.640065,
-0.01466761,
-0.07092498,
0.01678988,
-0.01647316,
0.4063518,
0.1910345,
0.10981... |
Fine structural analysis of rabbit synovial cells. II. Fine structure and rosette-forming cells of explant and monolayer cultures. | The fine structure and plasma membrane receptors of explant and monolayer cells of normal rabbit synovium were studied. In explants about 10% of the cells were round and formed rosettes with IgC and C3 markers, whereas the remaining cells were stellate, resembled young fibroblasts, and had no receptors for IgG and comp... | 181,009 | [
0.1975777,
-0.0557202,
-0.1327894,
-0.0856005,
0.07019544,
-0.195147,
-0.1165576,
0.294886,
0.02577025,
0.430938,
0.073384,
-0.2249315,
-0.03434046,
0.1099452,
-0.181463,
-0.006485107,
-0.09716667,
0.08889423,
-0.003982753,
0.2655124,
0.1382572,
0.1648183,
-0.101496,
-0... |
Determination of disulfiram and its metabolites in human blood. | This work was initiated by the lack of a sensitive method for the determination of disulfiram and its metabolites in blood of patients treated with this drug. A method is described which allows the separate determination of carbon disulfide, free diethyldithiocarbamate and disulfides derived from disulfiram with adequa... | 181,027 | [
-0.2606933,
0.3893351,
-0.2315824,
0.006049966,
0.03979611,
0.01992423,
-0.2596487,
0.3903141,
0.1058187,
0.1893317,
0.1060627,
0.3092282,
0.1367599,
-0.1979938,
-0.3512129,
-0.247958,
0.1159048,
0.01023507,
-0.04251172,
0.3317432,
0.1235782,
0.09961472,
-0.1994708,
0.0... |
[The effect of carbocromen on cardiac cyclic adenosine-monophosphate]. | The coronary-active drug 3-2-diethylaminoethyl)-4-methyl-7-(carbethoxy-methoxy)-2-oxo-1,2-chromene-hydrochloride (carbocromen, Intensain) is known to be an inhibitor of phosphodiesterase (PDE). After intravenous as well as after intraduodenal application of therapeutic doses carbocromen increases in vivo the cAMP-conte... | 181,028 | [
-0.315988,
0.08177099,
-0.1638706,
-0.3529591,
-0.1844891,
-0.1459634,
-0.2934121,
0.06998205,
-0.1022416,
-0.01040008,
-0.1618953,
-0.1042171,
0.287134,
0.05229557,
-0.5025185,
-0.1720224,
-0.8394941,
0.2246157,
0.01404137,
0.4375339,
0.4611295,
0.05700978,
0.01306154,
... |
Neutral glycosphingolipids of serum lipoproteins in Fabry's disease. | The neutral glycosphingolipid compositions of lipoprotein fractions of serum from eight healthy male volunteers and three patients with Fabry's disease were determined. Four fractions were studied: very low density lipoprotein (VLDL, d less than 1.006); low density lipoprotein (LDL, d 1.006-1.063); high density lipopro... | 181,056 | [
-0.1146393,
0.1245443,
-0.1785709,
0.1240227,
0.1622629,
-0.1101359,
-0.250005,
0.2638966,
-0.0267126,
0.1642808,
0.2394103,
0.20209,
-0.1055534,
0.1440488,
-0.08379819,
0.0523953,
-0.301699,
-0.1346703,
0.1714427,
0.100203,
0.1486159,
0.4352288,
-0.2243157,
-0.00496266... |
Purification and properties of paramagnetic protein from Clostridium pasteurianum W5. | The purification to homogeneity of the non-heme iron protein, sometimes referred to as either "red protein" or "paramagnetic protein", from Clostridium pasteurianum W5 extracts is described and its physicochemical properties studied. This paramagnetic protein (g= 1.94) has a molecular weight of about 25000 and contains... | 181,066 | [
-0.3985309,
0.01875886,
-0.1856908,
0.0120592,
-0.323418,
0.1134756,
0.1264809,
-0.05577275,
0.3007562,
-0.1561566,
0.03253454,
0.185747,
-0.0286097,
-0.1629881,
-0.3710258,
0.006837199,
-0.2091276,
-0.02829422,
0.2313834,
-0.06535412,
-0.03385315,
0.3880609,
-0.01286454,... |
ENDOR from nitrogens and protons in low spin ferric heme and hemoprotein. | Electron nuclear double resonance (ENDOR) signals have been obtained from iron-linked nitrogens in frozen solutions of cytochrome c, metmyoglobin cyanide, and a low spin protohemin mercaptide complex. Hyperfine couplings from heme protons have also been obtained from metmyoglobin cyanide and from a low spin protohemin ... | 181,067 | [
-0.3820291,
0.0108847,
-0.2041181,
0.284187,
-0.230692,
0.04527408,
-0.2213282,
-0.2163504,
0.09378859,
0.2048752,
-0.0002413992,
0.3007394,
-0.07626315,
-0.03252487,
-0.4422968,
-0.583315,
-0.2298068,
0.06567866,
-0.05706417,
-0.1957238,
0.2344653,
0.03406357,
-0.1161038... |
Aflatoxin inhibition of glucocorticoid finding capacity of rat liver nuclei. | The effect of aflatoxin B1 on the binding capacity of rat liver cytoplasmic glucocorticoid receptors and the nuclear binding of the activated receptor complex was investigated. No alterations in the kinetics of [3H]desamethasone-cytosol receptor complex formation were noted 2 h after treatment with 1 mg/kg aflatoxin B1... | 181,075 | [
0.06291025,
0.1311619,
-0.1957778,
0.1842187,
0.06859876,
-0.2819304,
-0.2042914,
0.1378818,
-0.09248759,
-0.002486856,
-0.04892646,
-0.08778383,
0.3437584,
0.08662321,
-0.3669928,
0.01918853,
-0.2641314,
-0.1013672,
0.02443494,
0.08662985,
0.5564096,
0.3403674,
0.0540905... |
Regulation of purine metabolism. Adenylosuccinate synthetase from Novikoff ascites tumor cells. | Adenylosuccinate synthetase has been partially purified from Novikoff ascites tumor cells. The properties of the protein are quite different from the enzyme from rat liver in that the Km for asparate is higher and the K1 for the feedback inhibitor AMP is also higher. The antibiotic hadacidin has a preferential inhibito... | 181,081 | [
0.02812476,
-0.04760361,
-0.2574238,
-0.03750053,
0.5252388,
0.06605927,
-0.1402592,
-0.08454546,
0.3957764,
0.06169558,
0.2213694,
-0.1112048,
0.2931967,
-0.03931819,
-0.8318897,
-0.01810974,
-0.6965483,
-0.2133767,
-0.31541,
-0.009629846,
0.200725,
-0.101312,
-0.2706403... |
Affinity chromatography of 3 alpha-hydroxysteroid dehydrogenase from Pseudomonas testosteroni. Use of N,N-dimethylformamide to prevent hydrophobic interactions between the enzyme and the ligand. | 1. The 3alpha-hydroxysteroid: NAD+-oxidoreductase (EC 1.1.1.50) from Pseudomonas testosteroni (ATCC 11996) has been purified by affinity chromatography on Sepharose 4B using glycocholic acid as ligand covalently bound through its carboxyl group to the ethylenediamine spacer. 2. The attachment of the enzyme to the subst... | 181,083 | [
-0.2967811,
0.01293549,
0.5284399,
-0.09089377,
-0.08672788,
-0.3135562,
0.06200384,
0.02130373,
-0.02150622,
0.1073005,
-0.004751399,
0.1801584,
-0.05018229,
0.1706739,
-0.228849,
0.3582498,
-0.3516727,
0.1574604,
-0.2429252,
0.1317228,
0.3816684,
0.005383928,
-0.0619694... |
On the location of active serines of membrane acetylcholinesterase studied by the ESR method. | 1. An attempt was made to find out the causes of the discrepancy between the ESR spectra of membrane acetylcholinesterase (EC 3.1.1.7) obtained by Morrisett and co-workers and those obtained by the present authors. 2. In order to see whether the discrepancy was due to the different spin-labeling procedures, the same me... | 181,084 | [
0.04442748,
0.09297116,
-0.02468553,
-0.1905923,
-0.3368475,
-0.2717308,
-0.1067118,
-0.03079822,
0.1162034,
0.06744675,
-0.08955713,
0.07908399,
0.1154602,
0.3245741,
-0.4716097,
0.1630317,
-0.6457673,
0.03087485,
-0.06973487,
0.2438869,
0.2139357,
0.1254262,
0.1455597,
... |
Biochemical assay by immobilized enzymes and a mass spectrometer. | By counting the volatile molecules produced by an immobilized-enzyme catalyzed reaction which is interfaced to a mass spectrometer via a semi-permeable membrane, a general approach to biochemical measurement and detection is obtained which offers the potential of high sensitivity, specificity and speed. In combination ... | 181,086 | [
-0.09848275,
-0.2311982,
-0.1148658,
0.2870776,
0.006373855,
-0.212676,
0.03563501,
0.1147238,
0.154615,
-0.08353166,
0.147239,
-0.2423818,
0.2028378,
0.08465675,
-0.7577432,
0.3916136,
-0.445601,
0.2460155,
-0.2268897,
0.1178463,
0.1762485,
0.3085423,
-0.1231486,
0.078... |
Steady-state kinetics of high molecular weight (type-I) NADH dehydrogenase. | (1) Studies of the steady-state kinetics of the NADH dehydrogenase activity of Complex I (NADH: Q oxidoreductase) revealed that the reaction mechanism with the one-electron acceptor ferricyanide or the two-electron acceptor 2,6-dichloro-indophenol is ping pong bi bi, with double substrate inhibition. NADH inhibits the ... | 181,089 | [
-0.1048013,
-0.03643972,
-0.1041598,
0.007822627,
0.160136,
-0.1482447,
-0.06688379,
0.06211334,
0.05512862,
-0.04616572,
0.2412187,
-0.1092204,
0.1775102,
0.2172161,
-0.5902913,
-0.09750483,
-0.3163612,
0.1081531,
-0.1174846,
0.174159,
0.04990803,
0.4701227,
-0.1305561,
... |
[Change in the mitotic activity of hepatocytes and resorption of necrotic areas in the formation of liver cirrhosis]. | Cirrhosis of the liver was induced in rats weighing 120--140 g by CCl4 administration for a period of 2 months. Iodated oil, which caused emboly of the portal vein branches and foci of necrosis in the heptic tissue, was administered through the spleen to experimental and intact animals. The volume of necrotic foci, and... | 181,102 | [
0.01889114,
0.103777,
0.1235737,
0.08430053,
0.009576251,
-0.3277405,
-0.09270246,
-0.2239568,
-0.06747676,
0.1862716,
-0.05920422,
-0.1035045,
-0.06657488,
0.1165041,
-0.9361423,
-0.1824702,
-0.2829554,
0.1268303,
0.05100251,
0.4182654,
0.07762843,
0.2691224,
0.001170412... |
Van Buchem's disease (hyperostosis corticalis generalisata) | The features of Van Buchem's disease are described, affecting six members of one family, spanning three generations of ages from 7 to 64 years. | 181,111 | [
-0.2191958,
-0.06185632,
0.1986132,
-0.1727006,
-0.1451121,
-0.3499072,
-0.15803,
-0.3906472,
-0.3677558,
-0.136097,
0.1348673,
0.1064399,
-0.02856557,
0.0242076,
-0.4114827,
-0.1222588,
-0.1461349,
0.2890832,
0.04137349,
0.1063483,
0.04674565,
0.3323569,
-0.09721053,
-... |
Effects of kainic acid, a cyclic analogue of glutamic acid, on cyclic nucleotide accumulation in slices of rat cerebellum. | The concentration of cyclic AMP (cAMP) and cyclic GMP (cGMP) in slices of rat cerebellum was increased markedly in the presence of 100 muM kainic acid, a cyclic analogue of glutamic acid. No acitvity was detected in other brain areas at various dosed or incubation times. Ksainic acid was significantly more potent than ... | 181,116 | [
-0.02190585,
0.1356992,
-0.3562439,
-0.1305139,
0.4539534,
0.236234,
-0.1705429,
-0.1271084,
0.004281301,
0.1300533,
0.06070954,
0.2992799,
0.1076824,
0.4247345,
-0.3273507,
0.17343,
-0.4844029,
0.2208429,
-0.3453066,
-0.0521184,
0.2535817,
-0.2032736,
0.2309515,
0.2469... |
Regulation of neuronal properties by afferent connections. I. Functional changes in snail neurons following section of presysnaptic nerve fibers. | The left cerebral connective of snail ganglia containing afferent inputs to a particular neuron was sectioned. One week after the operation synaptic potentials were not obtained when the connective was stimulated, and they had not reappeared after 60 days. The current-voltage relationship of denervated cells showed a r... | 181,117 | [
0.06085798,
-0.3397262,
0.02390199,
-0.1603818,
-0.08842,
-0.4083603,
-0.2328371,
-0.05111606,
0.1369235,
0.0223045,
0.06579436,
0.2888642,
-0.05641037,
-0.008828486,
-0.4190577,
-0.03197158,
-0.6975326,
0.05940603,
-0.2934081,
0.1276853,
0.06317575,
0.2249522,
0.1734975,... |
Postoperative radiation therapy for residual Wilm's tumor. Review of Group III patients in the National Wilm's Tumor Study. | Fifty-eight patients with residual abdominal disease (Group III) are reviewed from National Wilm's Tumor Study "1. The totap III) are reviewed from National Wilm's Tumor Study No. 1. The total number of abdominal recurrences is relatively low (eight cases). Local irradiation of the renal fossa would seem to be sufficie... | 181,122 | [
-0.4243186,
-0.165789,
-0.375058,
-0.6344224,
-0.1364546,
-0.4201003,
-0.5001323,
-0.1023077,
0.005290437,
-0.08943883,
0.2656296,
0.3409816,
-0.02810457,
-0.1806961,
-0.498296,
-0.1804141,
-0.1291822,
-0.130714,
0.1669652,
-0.2595652,
-0.146141,
0.1377949,
-0.2890614,
... |
Quantitation of elongating form A and B RNA polymerases in chick oviduct nuclei and effects of estradiol. | The number of elongating form A and B RNA polymerases in chick oviduct nuclei was estimated by measuring incorportaion of 3H-UTP into 3' termini of nascent RNA chains in the presence of heparin to inhibit initiation, and quantitation labeled uridine released from these termini after alkaline hydrolysis. The method corr... | 181,146 | [
0.1356341,
0.1417516,
-0.2596046,
-0.1259488,
-0.002633506,
-0.3074248,
0.2930539,
0.02990396,
0.3865369,
0.01624472,
-0.05136184,
-0.2282625,
0.1483565,
0.1735237,
-0.4064367,
0.3682868,
-0.01683435,
-0.07779174,
0.188517,
0.1481698,
0.7317117,
-0.1019358,
-0.1585598,
... |
[Prospective epidemiologic studies and the nature of the association between Epstein-Barr virus (EBV) and Burkitt's lymphoma (BL)]. | The prospective study carried out by the International Agency for Research on Cancer on the relationships between E.B.V. infection and Burkitt's Lymphoma development as well as their partial malaria chemoprophylaxy proposals, are discussed as an example of studying the role of a virus and of co-factors in one human can... | 181,158 | [
-0.1256058,
-0.1281864,
0.01189025,
0.02751002,
-0.02161879,
-0.3479478,
-0.3484423,
0.02846575,
-0.1166748,
0.1449941,
0.151755,
0.1048633,
0.2497814,
-0.01460782,
-0.6017277,
-0.2650385,
-0.05178029,
0.3313818,
0.1271706,
0.3833972,
0.3427884,
0.006283897,
-0.1963131,
... |
Electrophysiological studies in patients with chronic recurrent ventricular tachycardia. | Seventeen consecutive patients with chronic recurrent ventricular tachycardia (VT) were studied in an attempt to delineate the reproducibility and mechanism of this arrhythmia. Six patients had nonsustained and 11 had sustained VT. The following electrophysiological techniques were utilized in an attempt to reproduce V... | 181,168 | [
-0.1975058,
0.02498333,
-0.726328,
-0.606079,
0.3139332,
-0.2055245,
-0.2603646,
-0.1599932,
-0.099458,
0.05618036,
-0.03325462,
0.4758691,
-0.2561622,
-0.08573537,
-0.04247548,
-0.5882061,
-0.3223274,
0.1945482,
-0.09452765,
-0.2971251,
0.2192837,
0.03791207,
-0.323488,
... |
Body-surface maps of heart potentials: tentative localization of pre-excited areas in forty-two Wolff-Parkinson-White patients. | Heart potentials were recorded from the entire chest surface in 42 patients suffering from Wolff-Parkinson-White syndrome. We were able to identify six types of surface maps, according to the location of the potential maximum and minimum during the delta wave. For each of these types we suggested the most likely locati... | 181,170 | [
-0.2812786,
0.02590406,
-0.1208653,
-0.3507652,
-0.01738586,
-0.09202097,
0.00206587,
-0.4174131,
0.4542467,
0.2276035,
0.1476237,
0.02934249,
-0.01714965,
-0.1801172,
-0.352048,
0.09085198,
-0.5920725,
0.1060134,
0.06718149,
-0.18478,
0.2207891,
0.2438072,
-0.1107972,
... |
Maternal immunoglobulins and parainfluenza 3 virus inhibitors in the nasal and lachrymal secretions and serum of newborn lambs. | Concentrations of IgG, IgM and IgA were measured in the serum, nasal secretions and lachrymal secretions of suckled newborn lambs. The major immunoglobulin constituent of precolostral serum was IgM. Maternal immunoglobulins, of which IgG was predominant, reached peak values on day 1 of life and then declined over the n... | 181,185 | [
-0.1724384,
-0.3010604,
0.01482728,
-0.1512274,
0.02537966,
-0.06180105,
-0.1168516,
-0.1502935,
-0.1760693,
0.07610212,
0.09108892,
-0.1137576,
0.02404771,
-0.08126313,
-0.2009805,
0.1665465,
0.01289993,
0.3264385,
-0.4616915,
0.09662746,
0.1738508,
0.2846792,
-0.1386039... |
Transmission of auto-immune haemolytic anaemia and murine leukaemia virus in NZB-BALB/c hybrid mice. | When mated to normal BALB/c partners, male and female NZB mice transmitted auto-immune haemolytic anaemia to three generations of their hybrid progeny. Red cell auto-antibodies (positive Coombs tests) were detected, on average, 11 months later in the F1 hybrids than in the parental strain, and the course of the disease... | 181,187 | [
-0.01418087,
-0.2324529,
-0.2670841,
0.09423539,
0.3564621,
-0.2966883,
0.01890179,
-0.252627,
-0.07594495,
-0.1753208,
-0.1066469,
0.465648,
0.2314449,
0.01538215,
0.07189415,
-0.1469036,
0.02652906,
-0.1525649,
0.1273524,
-0.07307785,
0.2955846,
0.3133388,
-0.07396515,
... |
The effects of cyclic AMP on leucocyte inhibitory factor (LIF) production and on the inhibition of leucocyte migration. | The effect of drugs known to increase intracellular levels of cyllic AMP were studied in the leucocyte migration ihibition system. It was found that cyclic AMP, dibutyryl cyclic AMP, theophyline, and prostaglandins E1 and E2 inhibited the production of leucocyte inhibiting factor by HA pulsed lymphocytes Inhibition onl... | 181,189 | [
0.09417555,
-0.3376777,
0.04001978,
-0.2628552,
0.2541047,
-0.2405119,
0.2430751,
-0.09097689,
-0.1183293,
0.1105866,
-0.2631872,
0.04576176,
-0.3193971,
0.2391239,
-0.0282472,
0.007398837,
-0.5210055,
0.01496429,
-0.3003808,
0.3580213,
0.3966053,
-0.09194218,
-0.1533853,... |
Permeability of pulmonary vascular endothelium. | Three aspects of transendothelial exchange in the lungs are considered: stretching of interendothelial junctions of pulmonary microvessels by increase in pulmonary capillary pressures; selective stretching of interendothelial junctions of bronchial venules in response to histamine, bradykinin and endotoxin; active tran... | 181,219 | [
0.01502361,
-0.008512118,
-0.07763117,
0.05370197,
0.2554134,
-0.2404091,
0.1000261,
0.008314057,
-0.02541872,
0.1478159,
0.07881521,
-0.4529406,
-0.0466019,
0.223799,
-0.356208,
0.01127313,
-0.3792147,
0.07264635,
-0.03157886,
0.08452413,
-0.02722447,
0.3146409,
0.226916... |
Prohormones of beta-melanotropin (beta-melanocyte-stimulating hormone, beta-MSH) and corticotropin (adrenocorticotropic hormone, ACTH): structure and activation. | It is proposed that all peptide hormones and releasing factors are biosynthesized in the form of precursor molecules which are biologically inactive. Enzymic activation may take place by hydrolytic cleavage to release a terminal COOH group or by transmidation to form a COOH-terminal amide. Studies with pituitary prohor... | 181,227 | [
-0.2615886,
-0.3640216,
-0.2200192,
-0.008618093,
0.1568996,
-0.4434957,
-0.2250299,
0.2425544,
0.1964436,
0.1479269,
0.06217013,
-0.1546192,
0.3024084,
-0.1947704,
-0.01635876,
0.2249183,
-0.3085791,
0.1398081,
0.2838292,
0.3523294,
0.4254568,
0.06195128,
-0.4373078,
-... |
Nitrate reductase from Chlorella vulgaris. Reaction with manganese (III) pyrophosphate and with ferric o-phenanthroline. | Millimolar concentrations of tervalent manganese pyrophosphate can partially activate nitrate reductase which has been inactivated with NADH and HCN. The tervalent manganese complex is nevertheless not reduced by NADH in the presence of the enzyme, that is, it is not a substrate for the diaphorase moiety of the nitrate... | 181,248 | [
-0.3861482,
-0.2186486,
0.05129162,
-0.1062305,
-0.2035961,
-0.25369,
-0.1465232,
0.01041259,
-0.3151702,
0.03063029,
0.2792395,
0.3468328,
0.1399933,
-0.0222363,
-0.486709,
-0.3213417,
-0.6002756,
0.2322989,
0.1154645,
0.2682111,
0.1535963,
0.1093345,
-0.08618406,
0.20... |
Spectroscopic investigation of binary and ternary coenzyme complexes of yeast alcohol dehydrogenase. | Corrected fluorescence properties of yeast alcohol dehydrogenase and its coenzyme complexes have been investigated as a function of temperature. Dissociation constants have been obtained for binary and ternary complexes of NAD and NADH by following the enhancement of NADH fluorescence or the quenching of the protein fl... | 181,250 | [
0.02504517,
-0.1398892,
-0.0987292,
0.4356021,
0.0711543,
-0.3236134,
0.02744377,
0.2270176,
0.2705241,
0.04013482,
0.276768,
-0.3461506,
0.1350387,
0.1230197,
-0.6177365,
0.1759155,
-0.4787916,
0.006062922,
-0.1717497,
0.22195,
0.2926525,
0.410577,
0.0603599,
0.2064322... |
[Investigations of the morphology and the function of human Sertoli cells (author's transl)]. | Ultrastructurally and enzyme histochemically two types of activities of Sertoli cells are to be proved. By means of closest membrane contact and intensive energetic changes of substances, the active cells participate largely in the ripening of spermatozoa. Steroid biosynthesis in Sertoli cells is possible according to ... | 181,281 | [
0.3483776,
0.1428718,
0.04024995,
0.1865213,
0.06316394,
-0.3311217,
-0.06001575,
0.3687516,
0.2814901,
0.2316319,
0.07284903,
-0.002260037,
0.02334973,
0.01383722,
-0.4853391,
0.06234084,
-0.225723,
-0.07031751,
0.2389121,
0.1080402,
0.6823904,
0.09589965,
-0.2059839,
... |
Severe hemorrhagic varicella with visceral involvement: virological and serological studies during treatment with cytosine arabinoside. | A boy 13 year-old suffered an extremely severe and prolonged attack of hemorrhagic chickenpox with visceral involvement, the diagnosis being confirmed by isolation of varicella-zoster-virus (VZV). There was no other compromising disease. All preceding vaccinations including two against smallpox had been uneventful. The... | 181,329 | [
0.2094682,
0.04580153,
-0.2729259,
0.03722971,
0.215025,
-0.1723949,
-0.1010005,
-0.03560621,
-0.2801828,
0.09035885,
0.2228519,
0.1150493,
0.007589427,
-0.1203493,
-0.2781109,
-0.3262742,
-0.168337,
0.1887502,
-0.06641712,
0.4641311,
0.4345059,
0.1425079,
-0.2860492,
0... |
Epstein-Barr virus: experimental infection of Callithrix jacchus marmosets. | Eight common marmoset monkeys (Callithrix jacchus) were inoculated with about 10(4) transforming units of B95-8 virus; seven of the marmosets died 50-111 days post inoculation and all seven showed microscopic and/or macroscopic lesions compatible with a diagnosis of lymphoproliferative disease. Low levels of anti-VCA a... | 181,333 | [
-0.03637211,
-0.1214416,
0.03603568,
-0.5015737,
0.06588887,
0.008167499,
-0.5340935,
0.01782868,
0.162475,
0.281571,
0.4214203,
0.1524083,
0.1588316,
-0.02417082,
-0.2707881,
-0.1931392,
-0.09487167,
0.01536077,
0.1929869,
0.2652414,
0.4912943,
0.3343944,
-0.107009,
-0... |
Production of lymphoid tumors in hamsters by direct implantation of normal human peripheral and umbilical cord leukocytes. | Peripheral leukocytes from Epstein-Barr virus (EBV)-seropositive or seronegative normal adults, or human umbilical cord leukocytes infected or not infected with EBV, were directly transplanted into 50 newborn hamsters treated with anti-lymphocyte serum. Lymphoid tumors were produced after a latent period of 10-25 days ... | 181,336 | [
-0.02912433,
-0.1496358,
-0.3571424,
-0.07473063,
0.2284926,
-0.3208003,
-0.4289782,
0.1824714,
0.2232053,
0.1794722,
0.07149848,
-0.08523349,
0.1727771,
-0.0227677,
-0.2313278,
-0.2876132,
-0.4766696,
-0.01386607,
0.03736909,
0.03651922,
0.3247923,
0.08897836,
-0.1292952... |
The role of the psychiatric consultant in the treatment of burned patients. | Two cases of seriously burned patients are presented which differ in initial psychiatric presentation and subsequent course. In each case, the role of the psychiatric consultant is described. The role includes direct evaluative and psychotherapeutic contact with the patient and liaison with the surgical and nursing sta... | 181,340 | [
-0.1322162,
0.07224139,
-0.04452524,
-0.3438398,
-0.07280605,
-0.09465756,
-0.2330175,
-0.3214124,
-0.2460291,
0.4632007,
0.2265879,
0.1173379,
-0.2821242,
0.03917136,
0.2348168,
-0.05611105,
-0.07097644,
-0.03532792,
-0.1059769,
-0.01609622,
0.01545501,
0.05746166,
0.118... |
An EBV-genome-negative cell line established from an American Burkitt lymphoma; receptor characteristics. EBV infectibility and permanent conversion into EBV-positive sublines by in vitro infection. | An in vitro line was derived from an American Burkitt lymphoma, designated Ra No. 1, which produced malignant tumors when inoculated into thymus-deficient nude mice. The cells have B-lymphocyte characteristics, with surface-associated mu and kappa chains and Epstein-Barr virus (EBV) receptors, and can be readily infect... | 181,343 | [
-0.1198691,
-0.3723163,
-0.007076584,
-0.3391581,
0.05741026,
-0.1443317,
-0.02660777,
0.2460104,
0.06964342,
0.3344136,
0.2920607,
-0.09806482,
0.2970265,
0.1615455,
-0.6362225,
-0.0908807,
-0.2164553,
-0.04585949,
0.1308899,
-0.01873329,
0.07003835,
0.144272,
-0.0080949... |
Characteristics of immunity induced by neuraminidase-treated lymphosarcoma cells in C3H (MTV+) and C3H (MTV-) mice. | The immunogenicity of 6C3HED lymphosarcoma ascites tumor cells was greatly enhanced upon treatment with Vibrio cholerae neuraminidase. As a result, mammary tumor virus (MTV)-free C3H mice which had been repeatedly immunized with the treated cells resisted a challenge of 10(6) untreated viable cells inoculated i.p., whe... | 181,351 | [
0.1174414,
-0.0287824,
-0.06731676,
-0.4929689,
-0.1816645,
-0.3261785,
-0.07671444,
0.2908651,
0.02794751,
0.3114971,
0.0583429,
0.113068,
0.1549531,
-0.0352399,
-0.2059307,
-0.1773026,
-0.1890426,
0.06558666,
-0.2242869,
0.6495547,
0.3673872,
-0.2047932,
-0.2154113,
0... |
Interactions between lymphocytes and C-type oncornaviruses in mice. | Several aspects of C-type oncornavirus-lymphocyte interactions in the mouse are reviewed: 1) immunological abnormalities induced by C-type viruses, particularly immunosuppression and autoimmunity; 2) activation or amplification of endogenous C-type viruses during immunological reactions; and 3) the immune responses to ... | 181,353 | [
-0.1820375,
-0.06819069,
-0.1412783,
-0.09546007,
0.3332331,
-0.1587074,
-0.1337004,
-0.02238494,
0.1094968,
0.1592202,
-0.07559562,
0.1726301,
0.1777089,
0.1023038,
-0.2706462,
-0.1790489,
-0.2005621,
-0.1183413,
0.2872322,
0.2095481,
0.02444693,
-0.1223875,
-0.1667286,
... |
Thyroid antigen stimulates lymphocytes from patients with Graves' disease to produce thyroid-stimulating immunoglobulin (TSI). | Circulating lymphocytes from patients with Graves' disease and from control subjects were cultured in vitro alone, with normal human thyroid tissue homogenates, and with other nonthyroid human tissue homogenates. The supernatants of these cultures were assayed for human thyroid-stimulating activity by incubation with h... | 181,397 | [
-0.213113,
-0.297122,
-0.3451827,
-0.09072336,
0.3771243,
0.06287809,
-0.3166781,
0.3093337,
-0.0178641,
-0.01493422,
0.1051752,
0.2451705,
0.02787292,
-0.1949255,
0.0297268,
0.174887,
-0.5476371,
-0.2912665,
-0.287101,
0.3278947,
0.3363372,
0.2257154,
-0.2838042,
0.038... |
A 25-hydroxylation pathway of cholic acid biosynthesis in man and rat. | This paper describes a pathway of cholic acid synthesis, in man and in the rat, which involves 25-hydroxylated intermediates and is catalyzed by microsomal and soluble enzymes. The subcellular localization, stereospecificity, and other properties of the enzymes involved were studied with liver fractions of normolipidem... | 181,403 | [
-0.1670964,
0.05902405,
-0.02242777,
0.04265785,
-0.1879811,
-0.2599875,
-0.1956239,
-0.02787309,
-0.1417732,
0.04580767,
0.1161257,
-0.09631124,
0.2099763,
0.09572296,
-0.7572712,
0.03198657,
-0.5560336,
0.1334039,
-0.3701649,
0.2091112,
0.3018604,
0.4298853,
0.1460492,
... |
Histochemical localization of potassium-stimulated P-nitrophenylphosphatase activity in the somatosensory cortex of the rat. | Potassium-stimulated p-nitrophenylphosphatase (K+-pNPPase) activity was investigated in rat somatosensory cortex where 64-88% of enzymatic activity survived 5-10 min of fixation with 3% formaldehyde in 0.1 M cacodylate buffer, pH 7.4. Potassium-stimulated activity was inhibited by 1-10 mM ouabain. Levamisole (1.7 mM) i... | 181,489 | [
0.09269582,
-0.4334356,
-0.1245852,
0.1173912,
0.02336764,
-0.2658335,
-0.06953477,
0.3236036,
-0.1965736,
-0.002189487,
-0.2134897,
-0.0843583,
0.228486,
0.1479435,
-0.5170075,
0.1556131,
-0.4645514,
0.1179559,
-0.1662653,
0.5452036,
0.1351167,
0.05358355,
0.1390765,
0... |
Inhibition by rheumatoid factor, anti-FC, and staphylococcal protein A of antibody-dependent cell-mediated cytolysis against Herpes simplex virus-infected cells. | Incubation of herpes simplex virus-infected human fibroblasts with the serum from a patient with herpes labialis rendered the cells susceptible to immune lysis by human mononuclear leukocytes (MNL) as well as complement. If, before the addition of MNL, the antibody-treated, infected monolayers were incubated with eithe... | 181,492 | [
0.02200035,
-0.2167471,
0.2413458,
0.003250501,
0.2956357,
-0.06182136,
-0.3280515,
0.3716817,
-0.002184036,
0.4031618,
0.1961328,
0.3987132,
0.132245,
-0.2137705,
-0.04077824,
0.01093077,
-0.2498004,
-0.1096405,
-0.1750456,
0.439206,
0.1705033,
-0.08974022,
-0.4149001,
... |
Blood corticosteroids in Australian marsupial and placental mammals and one monotreme. | Peripheral blood corticosteroid levels were determined in nine species of Australian marsupial (Eastern grey kangaroo, black-tailed, Bennett's and pademelon wallabies, quokka, wombat, koala and Western native and tiger cats), one species of monotreme (echidna) and one placental Australian mammal (dingo). Animals were o... | 181,514 | [
-0.01995601,
0.09226375,
0.1032288,
-0.3510545,
-0.1259463,
-0.335116,
-0.4224621,
0.02177708,
-0.1206468,
-0.3340043,
0.02935608,
0.3265629,
0.08679361,
0.07709124,
-0.382666,
0.1197976,
-0.3185595,
0.1664243,
0.1269476,
0.2327613,
-0.018508,
-0.03900021,
-0.389813,
-0... |
Different patterns of polyadenylation of rhinovirus: specified RNA during multiplication in human aneuploid and diploid cells. | The polyadenylation of rhinovirus-specified RNA in aneuploid HeLa cells and diploid human embryo lung (HEL) cells has been investigated. Polyadenylation occurs at a faster rate and more extensively to virus-specified RNA in infected HEL cells compared with HeLa cells. Poly(A) is added post-transcriptively in both cell ... | 181,536 | [
-0.1452748,
-0.3041264,
-0.2294494,
0.205482,
0.4063882,
-0.271645,
-0.2215699,
0.06192178,
0.1871676,
0.202135,
0.03420086,
0.1744503,
0.007201344,
-0.04020384,
-0.2334046,
0.06563625,
-0.06554404,
0.04230142,
-0.1022763,
-0.2580985,
0.6554594,
0.1359041,
-0.2701451,
-... |
Rhythmic hyperpolarizations and depolarization of sympathetic ganglion cells induced by caffeine. | Superfusion of the isolated sympathetic ganglion of the bullfrog with a caffeine-containing (1-6 mM) solution caused in many cells an initial slow hyperpolarization which was followed by a subliminal depolarization interruped by rhythmic hyperpolarizations. A hyperpolarization, similar to one of the rhythmic hyperpolar... | 181,543 | [
-0.1765507,
-0.03191197,
-0.618108,
0.2139087,
0.1979503,
-0.4198415,
-0.1214766,
-0.107283,
0.1022072,
-0.08564317,
0.188574,
0.1617084,
0.1122923,
0.04707661,
-0.2599742,
-0.0406218,
-0.5392236,
-0.01992949,
-0.2887146,
-0.2396589,
0.1747687,
0.009939988,
-0.04155136,
... |
Arteriography in oral and maxillofacial surgery. | A brief review of the methodology of selective external carotid arteriography is presented together with its risks, complications, and contraindications. The indications for this procedure are described with illustrative case material to demonstrate its usefulness in both diagnosis and preoperative evaluation of variou... | 181,548 | [
-0.454367,
-0.1427832,
-0.1859632,
-0.3120549,
0.02061851,
-0.262558,
-0.3388338,
-0.3899611,
0.02957016,
0.05444857,
0.04177776,
0.025911,
-0.2183613,
-0.5121443,
-0.2224133,
-0.337807,
-0.3947367,
0.1246895,
0.1705564,
-0.02718698,
0.2402041,
-0.01317472,
0.006463436,
... |
Enzymatic penetration through intact sulcular epithelium. | To explore possible enzymatic penetration through intact sulcular epithelium tritium labeled hyaluronidase and collagenase were applied to the gingival sulcus of five white lip marmosets. One quadrant per monkey remained untreated. Each remaining quadrant was randomly assigned to one of the following modalities of appl... | 181,555 | [
-0.01267077,
-0.1797787,
-0.1038176,
0.09856593,
-0.1122641,
-0.3580975,
-0.122823,
-0.04543117,
0.4855402,
0.1068987,
0.2634812,
-0.0120373,
-0.04841557,
0.05869939,
-0.3529793,
0.1155252,
-0.216434,
-0.3340124,
-0.07350507,
0.0326495,
0.4968565,
0.1426715,
0.09892531,
... |
Induction of cholinergic enzymes in chick ciliary ganglion and iris muscle cells during synapse formation. | 1. In chick ciliary ganglia and irises, cholineacetyltransferase (ChAc) and acetylcholinesterase (AChE) activities were measured from the fifth day of incubation until 1 week after hatching. The changes in enzyme activity were correlated in time with previous electrophysiological and morphological findings of synapse f... | 181,563 | [
0.05880855,
-0.157774,
-0.3126691,
-0.5280728,
-0.0874152,
-0.249149,
-0.3214049,
0.2976272,
0.07826344,
0.09165157,
0.02229486,
0.02520205,
-0.05779214,
-0.4491839,
-0.4857698,
0.01717226,
-0.8319321,
0.2987902,
0.2675041,
0.08699412,
0.2812828,
0.06790413,
0.04524682,
... |
Amphotropic host range of naturally occuring wild mouse leukemia viruses. | Seven murine leukemia virus field isolates (uncloned) from wild mice (Musmusculus) of four widely separated areas in southern California show an unusually wide in vitro host range. They replicate well in human, feline, canine, guinea pig, rabbit, rat, and mouse cells, whereas bovine, hamster, and avian cells are resist... | 181,592 | [
-0.2921507,
-0.3542091,
-0.408783,
0.08327868,
0.2632228,
0.03074983,
-0.1871686,
-0.01795346,
0.04777431,
-0.02032749,
0.1280632,
-0.2738325,
0.02970691,
0.08928735,
-0.2696634,
-0.2358865,
-0.3485718,
0.1837834,
-0.1311626,
-0.1751594,
0.01816145,
-0.1952463,
-0.0781743... |
Fine structure of the URA2 locus in Saccharomyces cerevisiae. II. Meiotic and mitotic mapping studies. | The URA2 locus codes for a multifunctional enzyme complex carrying aspartate transcarbamylase (ATCase) and carbamyly phosphate synthetase (CPSase) activities. Three different types of ura2 mutants were tested in meiotic and mitotic recombination experiments: ura2A mutants devoid of ATCase activity, ura2C mutants devoid... | 181,668 | [
0.1020531,
-0.2388611,
0.07209789,
-0.08623774,
0.3295801,
0.09060061,
-0.2122576,
-0.02853649,
0.1190558,
0.1901842,
-0.01679244,
0.02482517,
0.07158361,
0.4207362,
-0.3106244,
0.3286817,
-0.02068253,
-0.1798676,
0.1347642,
-0.08503731,
0.3704444,
0.2318553,
0.1002392,
... |
Division delay and DNA degradation after mutagen treatment of the yeast, Saccharomyces cerevisiae. | The treatment of the yeast mutant TMP1-1, which is capable of incorporating low levels of 3H-thymidine-5' - monophosphate with UV light and ethyl methane sulphonate resulted in division delay when cultures were reinnoculated into fresh medium. The initiation of cell division was accompanied by the degradation of up to ... | 181,669 | [
-0.2216184,
-0.4168256,
-0.2142033,
-0.2079343,
0.1507141,
-0.1485033,
0.1398225,
-0.06771457,
0.2933524,
0.1112389,
0.1750427,
-0.07031223,
-0.2418215,
0.3024061,
-0.5946609,
0.1935049,
-0.2203725,
-0.066211,
-0.02253467,
0.2374321,
0.4985287,
0.2430254,
0.01072381,
-0... |
Effects of diethyldithiocarbamate on the catabolism of tyrosine in the rat brain. | 500 mg/kg sodium diethyldithiocarbamate (DDC) and trace quantities of uniformly labelled 14C-tyrosine were administered simultaneously to male albino rats of Porton-Wistar strain of approximately 210 g body weight. Thirty minutes later total radioactivity, the concentration and the specific activity of free tyrosine we... | 181,687 | [
-0.03853322,
0.2203057,
-0.3171145,
-0.0781873,
0.174467,
-0.2005107,
-0.2919327,
-0.3650656,
-0.3207121,
0.1274892,
-0.07848022,
0.3669547,
-0.09558129,
0.0924003,
-0.4086092,
0.05545933,
-0.06130802,
0.4278536,
0.1920761,
0.06829312,
0.1596794,
0.3245246,
-0.01722971,
... |
Long-term management of a case of carbamyl phosphate synthetase deficiency using ketanalogues and hydroxyanalogues of essential amino acids. | A 13-year-old girl with congenital deficiency of carbamyl phosphate synthetase has been treated intermittently for one year with a restricted protein diet supplemented by various mixtures of the alpha-ketoanalogues of valine, leucine, isoleucine, and phenylalanine, the D,L-alpha-hydroxyanalogue of methionine, and five ... | 181,726 | [
-0.1289237,
0.1071692,
-0.04593993,
-0.1035085,
0.4216896,
-0.3637425,
-0.2172407,
0.1583947,
0.0310034,
-0.05603739,
0.127118,
0.2207727,
-0.05598311,
0.3279855,
-0.2061738,
0.2841872,
-0.3431804,
0.1967378,
-0.08707103,
0.1591762,
-0.1886449,
0.235837,
0.08866304,
0.1... |
Monomer molecular weight of T antigen from simian virus 40-infected and transformed cells. | T-antigens from simian virus 40 (SV 40)-transformed and lytically infected cells have been isolated by immunoprecipitation and their molecular weights estimated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. T-antigen from SV40-transformed mouse and hamster cells has an apparent molecular weight of 94,00... | 181,749 | [
-0.2462981,
-0.02253471,
-0.09244692,
-0.08396083,
0.2783703,
-0.2903678,
-0.0777651,
-0.04746493,
0.08263712,
0.2531765,
0.05331117,
0.2377344,
0.3093583,
-0.1724244,
-0.08654517,
0.05332238,
-0.474328,
0.04404823,
-0.09741993,
0.2738006,
0.2145282,
0.2289601,
-0.3850463... |
Cord blood cholesterol, triglyceride, and lipoprotein pattern from two districts in Norway. | Lipid levels of cord blood from two districts in Norway were studied. Although the mean levels of cholesterol and triglycerides in the two populations were similar, high cord blood lipid levels were more frequently found in a population in Finnmark in northern Norway than in Bergen in western Norway. In Bergen the 95-p... | 181,835 | [
-0.0940932,
0.1189254,
-0.4648847,
-0.09979448,
0.3028923,
-0.4152442,
-0.5330085,
0.0645446,
0.1512286,
0.241543,
0.1861097,
-0.1628636,
0.3265705,
-0.2204078,
-0.2160085,
-0.3113615,
-0.2876914,
-0.09107474,
0.110399,
0.2171806,
0.4109823,
0.223506,
-0.2089552,
0.0095... |
[Synthesis of nicotinamide adenine dinucleotide in the nuclei of pigeon erythrocytes]. | The nuclei of pigeon erythrocytes are capable of synthesizing NAD from nicotinamid-mononucleotides and ATP. Some data on the kinetics of NAD-pyrophosphorylase have been obtained: the optimal concentration of nuclei and the effect of various incubation time. The pretreatment of nuclei by Triton X-100, or by ultrasonics ... | 181,878 | [
-0.05897932,
-0.08777118,
-0.1888678,
0.03032477,
0.5863706,
-0.2532936,
-0.21618,
-0.03805513,
0.03557136,
0.009090933,
0.2721486,
0.2909344,
-0.006088233,
0.2746114,
-0.6959744,
0.01754058,
-0.5044832,
0.0008171644,
-0.3576811,
0.2193293,
0.8298484,
0.1183223,
-0.416808... |
Oocyte maturation and glycolysis in isolated pre-ovulatory follicles of PMS-injected immature rats. | Graafian follicles were isolated by microdissection from the ovaries of PMS-injected immature rats killed at specific times on the day before ovulation. They were incubated in Krebs bicarbonate buffer containing 5 mM glucose and 1% bovine serum albumin. The oocytes were recovered after incubation and examined by Nomars... | 181,938 | [
-0.05687858,
-0.04809687,
-0.491211,
-0.190588,
0.1210333,
-0.08456233,
0.2756893,
0.02447069,
-0.1779338,
-0.2266536,
-0.2104072,
0.2391155,
-0.1128617,
0.05033543,
-0.3749696,
0.1672698,
-0.526791,
0.03026491,
0.05094015,
0.1431797,
0.3236114,
0.2851767,
-0.01186177,
... |
Intramitochondrial crystalline inclusions in the liver of a patient with hyperthyroidism. | The case of a female patient with hyperthyroidism and slightly impaired liver function is described. Histological examination of liver biopsy did not reveal any pathological findings. Electron microscopic examination revealed crystalline inclusions in a great number of the mitochondria of the liver cells, as well as in... | 181,939 | [
-0.2147497,
-0.04132733,
-0.06993639,
0.1596249,
-0.08909438,
-0.09022707,
-0.1996787,
0.05051897,
0.04531854,
0.1226419,
0.1402726,
0.03486992,
-0.1751904,
0.2569968,
-0.236005,
0.1287629,
-0.2975596,
-0.1113307,
-0.09535057,
0.1538899,
0.3688703,
0.3514793,
-0.04458929,... |
Dissociation of phagocytosis, metabolic stimulation and lysosomal enzyme release in human leukocytes. | In this paper studies are reported concerning the relationship between particle binding to the plasma membrane of human polymorphonuclear leukocytes (PMN's), phagocytosis, generation of oxidative metabolites, and the release of lysosomal enzymes by these cells. Superoxide (O2-) generation by, and lysosomal enzyme relea... | 181,968 | [
0.1784767,
-0.2091779,
-0.1098583,
0.2200114,
-0.02132571,
-0.3315282,
0.01482732,
0.08148235,
-0.4648521,
0.2318021,
-0.1095578,
0.007845205,
-0.1307576,
-0.09630699,
-0.1062341,
-0.03190272,
-0.4406529,
-0.1022992,
0.4248203,
0.3266054,
0.2018408,
0.3103781,
-0.1219882,... |
The macrophage as a secretory cell in chronic inflammation. | Although it is clear that macrophages are always present at sites of chronic inflammation their contribution to the evolution of these lesions is not well understood. In vitro studies have shown that macrophages secrete a variety of products on exposure to different stimuli. These include hydrolytic enzymes, active at ... | 181,971 | [
-0.2072536,
-0.1698283,
-0.2332871,
0.3853831,
-0.1390404,
-0.4182035,
0.06383613,
0.1617424,
0.214693,
0.3739837,
-0.2460221,
0.02161007,
0.01927026,
0.0058208,
-0.07972985,
0.01616925,
-0.3836534,
-0.06153591,
0.4420716,
0.2163632,
0.1623985,
0.06196705,
-0.2331306,
0... |
Colonic changes of herpes zoster. | The lesions of herpes zoster of the colon were observed in three cases. Small polygonal mucosal blebs or small ulcerations involving a short segment of the colon and appearing in a reasonable time relationship with the cutaneous manifestations either in a corresponding or noncorresponding dermatome should enable diagno... | 182,006 | [
-0.03943289,
-0.04619817,
-0.1348377,
-0.04155647,
-0.0561479,
-0.4322295,
-0.1838992,
-0.01822502,
-0.1984249,
-0.01320473,
0.2191907,
-0.01124481,
0.09664439,
-0.1528159,
-0.1570409,
0.09415872,
-0.01205642,
0.1420295,
0.288289,
-0.2861902,
0.4940022,
-0.04155054,
0.245... |
Preoperative radiation therapy in endometrial carcinoma: preliminary report of a clinical trial. | A total of 91 patients with stage I endometrial adenocarcinoma who were referred for radiation prior to hysterectomy were randomly allocated to recieve either intracavitary or external bean irradiation. Total abdominal hysterectomy was done 4-8 weeks later. The 53 patients who received intracavitary irradiation had an ... | 182,014 | [
-0.1052793,
-0.1683959,
-0.3369668,
-0.2446621,
0.04982548,
-0.4121048,
0.1165677,
-0.2983949,
0.2110851,
0.04630266,
0.1340629,
0.2410938,
-0.02370534,
-0.2551373,
-0.2321958,
-0.0402757,
-0.2738646,
0.2721203,
-0.0690005,
-0.1929479,
-0.09577189,
0.2921872,
-0.04031968,... |
Fast neutron beam radiotherapy of glioblastoma multiforme. | Twenty-one patients with glioblastoma multiforme were treated with fast neutron beam irradiation of the whole brain. Therapy was well tolerated up to calculated doses of 1.850 radn+y in 12-18 increments over 6 weeks. The survival rate 6 month after initiation of treatment was 62%, not significantly different from conve... | 182,016 | [
-0.1032178,
0.1515872,
0.002335975,
-0.09454871,
0.08659066,
-0.4295981,
0.0173145,
0.03013444,
-0.1491646,
0.1759352,
-0.2397715,
0.3058848,
0.2136266,
0.1020767,
-0.5775266,
-0.08192183,
-0.114653,
0.1008841,
0.1417516,
0.2260257,
0.2968947,
0.4672721,
-0.03830022,
0.... |
[Insulinomas in children. Histologic and ultrastructural study. (apropos of 2 cases)]. | The authors report two case-histories of insulin-secreting tumors of the pancreas in children. They emphasize the rare occurence and the percularity of these tumors with regard to insulinomas in adults. The ultrastructural and histopathological examination showed: --the presence of a "junction area" rich in centro-acin... | 182,046 | [
-0.1434272,
-0.3617838,
-0.1445907,
0.02501346,
0.06432237,
-0.2528777,
-0.4610877,
0.229338,
0.3507313,
0.2679383,
0.1402711,
-0.06012502,
-0.2378037,
-0.4502797,
-0.5276061,
-0.3249121,
0.08394802,
0.2826668,
0.2218264,
0.03615963,
0.4512669,
-0.09751762,
-0.007408801,
... |
Lymph nodes and vessels in primary lymphoedema. Their relative importance in aetiology. | The classification of lymphoedemas is reviewed and the various primary lymphoedemas distinguished from the secondary. The early lymphographic studies of primary lymphoedemas (many of which arise from genetic factors) probably laid undue emphasis on changes in the lymphatic vessels. Oil contrast media in leter use in ly... | 182,058 | [
-0.06097691,
-0.04251796,
0.01044518,
-0.1663037,
0.02630323,
-0.3869075,
-0.1940972,
-0.2886186,
0.006431976,
0.3867493,
0.4139801,
0.1415153,
0.004854114,
-0.2412611,
-0.3411882,
-0.0573964,
-0.005894543,
0.01428394,
0.0417077,
0.2729023,
0.2393444,
0.3151608,
-0.161291... |
Microtiter assay for interferon: microspectrophotometric quantitation of cytopathic effect. | This report describes an accurate, reproducible, and efficient microassay for human interferon, using a dye-uptake method to quantitate cytopathogenicity. The antiviral activity was measured by using a Gilford 300-N microsepctrophotometer, with the automatic programmer, sampler, and data lister. Two hundred interferon ... | 182,074 | [
-0.2212878,
0.06812166,
-0.2206968,
-0.04520564,
0.2863379,
-0.149806,
-0.3686439,
0.1246323,
0.09116564,
-0.09352762,
0.1966879,
0.1725839,
0.09310032,
0.3903491,
-0.4185776,
-0.1539244,
-0.02696086,
0.1167215,
0.01130046,
0.3106564,
0.5057486,
0.1700791,
0.1218404,
-0... |
Endocrinopathy in thalassaemia major. | Pituitary, adrenal, and pancreatic functions were investigated in 9 patients with thalassaemia major. 9 a.m. plasma ACTH values were 148-480 pg/ml (normal range 15-70 pg/ml). Cortisol and growth hormone response to insulin-induced hypoglycaemia was normal in all. 24-hour urinary excretions of 17-ketosteroids and 17-hyd... | 182,088 | [
-0.03645563,
-0.2804938,
-0.3835312,
-0.1281754,
0.1152081,
-0.1392551,
-0.2542436,
0.02550096,
-0.1794091,
0.0141327,
0.2900475,
0.1993751,
-0.1035943,
-0.3426933,
-0.3819283,
-0.1326701,
0.07983958,
-0.00124118,
-0.2388142,
0.01631098,
0.3861231,
0.2323042,
0.1315451,
... |
Immunological characterization of an arylamidase (aminopeptidase) occurring in histiocytoma. | Histiocytomas display a remarkably strong proteolytic activity. Electrophoretic and immunological studies reveald that this proteolytic activity is due, at least partially, to the presence of an arylamidase, previously described as "aminopeptidase I". This enzyme has been identified in various tissues of ectodermal, me... | 182,090 | [
-0.1717974,
-0.3137285,
-0.2940037,
-0.1719468,
0.08251178,
-0.2305303,
-0.4145307,
0.107524,
0.122118,
0.1703033,
0.1732101,
-0.2119486,
0.13158,
-0.2074968,
-0.0983784,
0.1989462,
-0.4381531,
0.2226974,
0.003164425,
0.2205454,
0.1488028,
0.04179061,
-0.1712484,
-0.123... |
Role of membranes in bile formation. Comparison of the composition of bile and a liver bile-canalicular plasma-membrane subfraction. | 1. Enzymes, proteins, glycoproteins and lipids of rodent bile were compared with those of a plasma-membrane subfraction originating from the hepatocyte bile-canalicular membrane. 2. Three bile-canalicular glycoprotein enzyme activities were detected in bile. Comparison of the pH optimum and immunoinhibition properties ... | 182,122 | [
0.05102114,
-0.06494788,
-0.4348317,
0.06622329,
0.1629248,
-0.3042263,
0.01964689,
0.01991775,
0.09302601,
0.07156558,
0.0685876,
-0.4485165,
0.0008331233,
0.1733165,
-0.3915423,
-0.04887047,
-0.4017842,
0.0505647,
-0.06281123,
0.271942,
0.2674966,
-0.0131436,
-0.0460636... |
Development and properties of fructose 1,6-bisphosphatase in the endosperm of castor-bean seedlings. | 1. The activity of fructose 1,6-bisphosphatase (EC 3.1.3.11) in the fatty endosperm of castor bean (Ricinus communis) increases 25-fold during germination and then declines. The developmental pattern follows that of catalase, a marker enzyme for gluconeogenesis in this tissue. 2. The enzyme at its peak of development w... | 182,124 | [
-0.1639732,
0.01298868,
-0.3149074,
-0.1011599,
0.2176242,
-0.4115941,
0.06004789,
0.1846959,
-0.03407237,
0.1243056,
0.1965492,
0.09826128,
-0.06978103,
0.3906751,
-0.02094562,
0.0476046,
-0.5444506,
0.2746273,
-0.04128142,
0.2688516,
0.4000067,
0.3913048,
-0.3322678,
... |
Reactions involving superoxide and normal and unstable haemoglobins. | Superoxide ions (O2-) oxidized oxyhaemoglobin to methaemoglobin and reduced methaemoglobin to oxyhaemoglobin. The reactions of superoxide and H2O2 with oxyhaemoglobin or methaemoglobin and their inhibition by superoxide dismutase or catalase were used to detect the formation of superoxide or H2O2 on autoxidation of oxy... | 182,128 | [
-0.13077,
-0.1562354,
-0.4736442,
-0.0612904,
0.01421739,
-0.1118459,
-0.3003315,
-0.2075877,
-0.1613851,
-0.03147531,
0.2085633,
0.5279168,
0.02935185,
-0.03551654,
-0.02267642,
-0.2060846,
-0.09702751,
0.2266266,
0.1665949,
0.1393167,
0.3202049,
0.4703559,
0.1245181,
... |
Phospholipid composition of the plasma membrane of the green alga, Hydrodictyon africanum. | A plasma-membrane fraction was isolated from the alga Hydrodictyon africanum by micro-dissection and its phospholipid components were analysed. Phosphatidylcholine was the major phospholipid of the preparation. Both phosphatidylserine and diphosphatidylglycerol were enriched in the fraction compared with the whole cell... | 182,144 | [
-0.1059269,
0.0880482,
-0.2302477,
-0.0752224,
0.07771309,
-0.0855125,
-0.4334424,
0.4124633,
0.2581105,
0.0270281,
0.03801835,
0.02264612,
-0.2774858,
-0.2365336,
-0.08633841,
-0.1874675,
-0.07632688,
0.3100684,
-0.02681173,
0.2012003,
0.4065416,
0.4894688,
-0.01203712,
... |
Long-term effects of a high glucose concentration on cyclic nucleotide phosphodiesterase activity in mouse pancreatic islets maintained in tissue culture. | It has been suggested that the stimulatory effect of glucose on insulin release may be mediated by the adenylate cyclase-cyclic AMP phosphodiesterase system. In this study it was found that exposure of isolated pancreatic islets to an elevated extracellular glucose concentration for 1 week in vitro caused an increase o... | 182,150 | [
-0.1178647,
-0.5165496,
-0.4818243,
0.1118138,
0.1846895,
-0.1562116,
-0.04076249,
0.368949,
-0.03135814,
0.1056175,
0.05577428,
-0.2146261,
-0.1189924,
0.1399509,
-0.37959,
-0.1262658,
-0.2907307,
0.1147227,
-0.0004769667,
0.2145518,
0.3338524,
0.2735194,
0.02786734,
-... |
Effect of hypertension on the entry of 125 I-labelled low density lipoprotein into the aortic intima in normal-fed rabbits. | The entry of [125I]-labelled low density lipoprotein (LDL) into different regions of the aortic intima has been studied over a 6 hour period in both normotensive and renal hypertensive rabbits fed a normal diet. Studies have also been carried out in previously hypertensive rabbits in which the blood pressure was normal... | 182,187 | [
-0.09234357,
-0.1981411,
-0.1658377,
0.2983662,
0.2209708,
-0.4481242,
-0.2572594,
-0.01710321,
0.391558,
-0.1901019,
0.2174625,
-0.1598891,
0.08346757,
-0.283467,
-0.5465499,
-0.1315328,
-0.6807498,
-0.1140105,
-0.2640665,
0.08437771,
-0.06860382,
0.223095,
-0.2171616,
... |
The innate resistance of CBA mice to endogenous murine leukaemia virus infection. | The incidence of lymphomata in CBA mice is low and furthermore is unaltered by transplantation at the early blastocyst stage and being born from the lymphoma-prone AKR. The number of C-type murine leukaemia virus particles in CBA derived in this manner and milk-fostered by AKR mice in no way differs from normal CBA. Th... | 182,192 | [
-0.1926416,
-0.2296121,
-0.2997486,
-0.103773,
0.2200764,
-0.2961476,
0.03805553,
-0.1834498,
0.1318782,
0.201717,
0.004761386,
0.2008347,
0.22727,
0.4294985,
-0.3028463,
-0.1528583,
-0.5178921,
-0.1167533,
-0.1964283,
-0.185489,
0.283652,
0.1325175,
-0.001513294,
0.130... |
Factors influencing the response of Escherichia coli to antibiotics in conditions prevailing in the infected urinary bladder. | The response of a sensitive strain of Escherichia coli to a variety of antibiotics was examined in an in vitro model which simulates the hydrokinetic features of the urinary bladder. Recovery of bacterial cultures from antibiotic effects was observed following exposure to bactericidal and bacteristatic antibiotics and ... | 182,196 | [
-0.01422688,
-0.1624165,
-0.3306808,
-0.02857153,
-0.1022701,
-0.243145,
-0.3352796,
-0.1679882,
0.03868026,
-0.1039911,
0.1155421,
0.08833931,
-0.1550194,
0.1882157,
-0.4769016,
-0.06102485,
-0.02209225,
0.2607802,
-0.2664165,
-0.04167537,
0.3985074,
0.1502138,
0.0024117... |
Atherogenic hyperlipoproteinemia induced by cholesterol feeding the Patas monkey. | Patas monkeys were studied for 2 years on three dietary regimes: (1) commercial chow (control diet); (2) semipurified diet plus lard (fat-fed); and (3) semipurified diet plus lard and cholesterol (cholesterol-fed). The control and fat-fed animals had similar lipoproteins which were equivalent to the human very low dens... | 182,200 | [
0.0711196,
0.08974013,
0.1316694,
0.06571721,
0.2549217,
-0.4401731,
-0.07520978,
-0.06971654,
-0.02754379,
0.1397077,
-0.009209474,
-0.0382621,
0.2429653,
0.06428611,
-0.4213945,
-0.05105425,
-0.4467182,
-0.1518741,
0.165695,
-0.1846386,
-0.1123977,
0.3204778,
-0.0401809... |
Alterations in lipid acyl group composition and membrane structure in cells transformed by Rous sarcoma virus. | The acyl group composition of the phospholipids from normal chick embryo fibroblasts and from cells transformed by Rous sarcoma virus was determined by gas-liquid chromatography. Rous-transformed cells had less arachidonate (20:4) and more oleate (18:1) in membrane lipids than normal, growing cells. Normal density-inhi... | 182,208 | [
-0.2587464,
-0.04555759,
-0.3347691,
-0.3368962,
0.2335138,
-0.2661273,
-0.08023918,
0.2327288,
0.1859088,
0.143577,
0.1226772,
-0.5202317,
-0.1092048,
0.06770646,
-0.6110389,
0.1786177,
-0.1913274,
0.2796745,
-0.006158685,
0.3524728,
0.2419484,
0.09494325,
-0.413869,
0... |
Arthrobacter luteus restriction endonuclease recognition sequence and its cleavage map of SV40 DNA. | The nucleotide sequence at the cleavage site of the restriction endonuclease isolated from Arthrobacter luteus (Alu) has been determined. The endonuclease cleaves at the center of a palindromic tetranucleotide sequence to give even-ended duplex DNA fragments phosphorylated at the 5'-end. The endonuclease cleaves SV40 f... | 182,213 | [
-0.1717133,
-0.02682594,
-0.08090055,
-0.0452087,
-0.1126201,
-0.02327204,
-0.1844159,
0.323379,
0.1321347,
0.1744261,
0.1620499,
-0.008541364,
0.009902622,
-0.2048663,
-0.2605205,
-0.124762,
-0.7002759,
0.3660398,
0.04264508,
0.04880266,
0.4319001,
0.1865515,
-0.3203266,... |
Study of cytochrome oxidase co-binding site using low-temperature flash photolysis. | Flash photolysis has been used to study the kinetics of CO-binding to the heme alpha isolated cytochrome oxidase. Experiments performed over the range 185-295 degrees K with various CO concentrations have revealed significant deviations from the Arrhenius relationship between rate and temperature. These findings can be... | 182,221 | [
-0.2624904,
-0.141185,
-0.4003176,
0.3792637,
-0.1582491,
-0.2479838,
-0.2388601,
0.1025782,
-0.05044502,
-0.1859232,
-0.02692592,
0.1084964,
0.02863541,
-0.1305932,
-0.6636522,
-0.01488523,
-0.3079066,
0.09119241,
0.1017888,
0.2047154,
0.1968119,
0.2298746,
-0.2219713,
... |
Production of superoxide anion during the oxidation of hemoglobin by menadione. | Menadione in the presence of oxyhemoglobin will accelerate the formation of methemoglobin and result in the generation of superoxide anion. Menadione appears to oxidize slowly ferrohemoglobin to ferrihemoglobin, while forming menadione semiquinone in the process. Menadione semiquinone is known to react with molecular o... | 182,230 | [
-0.6162919,
0.06775261,
-0.3861333,
0.07284544,
0.01020254,
-0.03372397,
-0.2435229,
-0.01039886,
-0.2022859,
-0.07678548,
0.1855343,
0.422872,
0.1448725,
-0.08606798,
-0.215848,
-0.1447228,
-0.1540783,
0.2451628,
0.008630244,
-0.03760922,
0.3134471,
0.058643,
0.05377556,... |
Human thyroid cyclic nucleotide phosphodiesterase. Its characterization and the effect of several hormones on the activity. | Cyclic AMP and cyclic GMP phosphodiesterase activities (3',5'-cyclic AMP 5'-nucleotidohydrolase, EC 3.1.4.17) were investigated in the human thyroid gland from patients with hyperthyroidism. Low substrate concentration (0.4 muM) was used. About 60% of the cyclic-AMP and 80% of the cyclic-GMP hydrolytic activities in th... | 182,233 | [
-0.4008914,
-0.2228592,
-0.3255468,
-0.1203966,
0.05195462,
-0.314562,
-0.183103,
0.05607412,
-0.1039607,
0.197923,
0.1050997,
0.05267826,
-0.02326113,
-0.02073565,
-0.2333093,
0.1049734,
-0.3510254,
-0.006150089,
-0.1042584,
0.3782589,
0.5580705,
0.2020705,
-0.335668,
... |
On the role of the collagen carbohydrate residues in the platelet. Collagen interaction. | It has been proposed that the platelet : collagen interaction is mediated in part by the collagen carbohydrate residues. To test this hypothesis we have oxidized monomeric and polymeric collagen with sodium periodate under conditions specifically designed to minimize destruction of periodate-susceptible bonds other tha... | 182,269 | [
-0.1164367,
0.2058652,
-0.2958881,
0.2051667,
-0.231642,
-0.2518525,
0.1563194,
0.3497131,
0.2679758,
0.1023117,
-0.09929167,
0.00214634,
-0.1709428,
-0.2360245,
-0.1899082,
-0.3014134,
-0.0002055884,
0.04172962,
-0.08072415,
0.2501999,
0.1041841,
0.06767881,
-0.02607635,... |
Purification, characteristics and sequence of a peptide containing an essential lysine residue. | Glutamate dehydrogenase (EC 1.4.1.2-4) has been purified and crystallized from the acetone powder of tuna liver. The enzyme has a molecular weight of 333 000 +/- 15 000 as evaluated by sedimentation equilibrium and constists of six identical subunits. Unlike the bovine enzyme the molecular weight does not increase with... | 182,270 | [
-0.04254889,
0.3018023,
0.05112664,
0.2048621,
-0.3098524,
-0.2150175,
0.04003362,
0.07609349,
0.08998002,
0.1705854,
0.1684015,
0.1815193,
0.2180495,
0.1937887,
-0.5230671,
0.1293147,
-0.3976275,
-0.03596307,
0.1001723,
0.2788242,
0.1221389,
0.3542167,
-0.09122147,
0.2... |
Isolation and properties of a cyclic guanosine-monophosphate sensitive intracellular ribonuclease from Bacillus subtilis. | A ribonuclease was isolated and completely purified from sporulating cells of Bacillus subtilis. This RNase has a M.W. of about 150,000 daltons. It hydrolyzes single stranded RNA and single stranded synthetic polynucleotides yielding nucleoside 5'-monophosphates. The enzyme is an exonuclease which degrades polynucleoti... | 182,287 | [
-0.2357689,
-0.2410293,
-0.2276931,
-0.1379993,
0.122936,
-0.2026278,
-0.1679816,
-0.002162886,
0.1448062,
-0.2508828,
0.08288199,
0.4702507,
0.2391929,
0.1945252,
-0.5129623,
0.1454707,
-0.3327876,
-0.05253269,
-0.1235841,
-0.03730886,
0.610078,
-0.06447912,
-0.06481045,... |
Treatment of Nelson's syndrome by pituitary implantation of yttrium-90 or gold-198. | Eight patients with Nelson's syndrome were treated with a pituitary implant of yttrium-90 or gold-198 four to 16 years after adrenal surgery. All had considerable pigmentation. One already had cranial nerve abnormalities and visual field defects and had had both a craniotomy and deep x-ray treatment. Radiographs showed... | 182,313 | [
0.1946219,
-0.1930152,
0.09982625,
-0.1700129,
-0.06130312,
-0.2294978,
-0.003656408,
-0.06717991,
0.2963581,
0.4524277,
0.21861,
-0.19746,
-0.1605794,
-0.2972133,
-0.2839482,
0.0622605,
0.02100062,
0.05028726,
-0.291191,
-0.02205231,
0.2321177,
-0.05051344,
0.3096353,
... |
CYCLIC AMP/*SECRETl cyclic AMP into push-pull perfusates in freely moving rats. | Cyclic AMP was found in perfusates of push-pull cannula's, chronically placed in the lateral ventricle of freely moving rats. After addition of norepinephrine, dopamine or adenosine to the perfusates the output of cyclic AMP was enhanced, whilst serotonin and histamine were found to be ineffective. The effects of norad... | 182,325 | [
-0.05411835,
-0.2523685,
-0.191652,
-0.3481041,
0.2558442,
-0.3856707,
-0.3747308,
0.02822105,
-0.3092683,
0.3208016,
0.02687653,
0.331836,
0.03134758,
0.09310818,
-0.3598336,
0.05284558,
-0.2967819,
-0.08423813,
-0.0804133,
-0.3205727,
0.09084034,
-0.2665093,
-0.1453524,... |
The induced biosynthesis of 7-dehydrocholesterols in yeast: potential sources of new provitamin D3 analogs. | The effect of low concentrations of a specifically designed sterol-24-transmethylase inhibitor, 25-aza-24, 25-dihydrozymosterol (10) on sterol production in Saccharomyces cerevisiae was examined. The synthesis of cholesta-5,7,22,24-tetraen-3beta-ol (4), its 7,22,24 analog (15) and the 7,24 analog (5) coupled with the a... | 182,342 | [
-0.245934,
0.05864606,
-0.009004219,
-0.4883197,
0.08197134,
0.09556413,
0.09944712,
0.1544763,
0.134508,
-0.1610695,
0.1941182,
-0.08820669,
0.0208041,
-0.1059667,
-0.5574825,
0.3304327,
-0.7234919,
0.08134751,
-0.2256743,
0.2722372,
0.2484523,
0.6225668,
-0.1650343,
0... |
Diphosphoinositide metabolism in bovine adrenal medulla. | (1) A phosphatidylinositol kinase (EC 2.7.1.67) of a chromaffin vesicle membrane preparation isolated from bovine adrenal medulla was characterized. Its activity towards endogenous and exogenous phosphatidylinositol was very similar to the kinase activity of the microsomal fraction prepared from the same tissue. (2) Ph... | 182,344 | [
-0.4306648,
-0.03968567,
-0.360902,
-0.2712021,
-0.08258941,
-0.2435127,
-0.05140113,
0.2758664,
-0.0333928,
0.04334427,
0.3115884,
0.03214097,
-0.1384463,
-0.3076901,
-0.7216977,
-0.02297345,
-0.6409869,
0.08598302,
0.3665873,
-0.003112117,
0.3462462,
0.4687385,
-0.22666... |
Response of plasma fibrinogen and plasminogen to hormone treatment and the relation of pretreatment values to mortality in patients with prostatic cancer. | Fibrinogen and plasminogen were measured in plasma samples from prostatic cancer patients before and after 3 months of treatment with either Premarin, Provera, Provera and diethylstilbestrol, one of three doses of diethylstilbestrol, or placebo. Plasminogen levels generally were increased significantly with the estroge... | 182,348 | [
-0.02965656,
-0.002490812,
-0.1271969,
-0.1411885,
-0.02286075,
-0.6503505,
0.229836,
0.3369334,
0.1158211,
0.146338,
-0.0311139,
0.3623005,
0.07247154,
-0.2989223,
-0.03129165,
0.09619097,
0.01023467,
-0.1386609,
-0.02368711,
0.580523,
0.4798985,
0.1015234,
-0.4152409,
... |
Trophoblastic pseudotumor of the uterus: an exaggerated form of "syncytial endometritis" simulating a malignant tumor. | Twelve cases of a hitherto unrecognized pseudotumorous trophoblastic invasion of the myometrium are analyzed. Human chorionic gonadotropin (HCG) was identified by an immunoenzyme technique in the cytoplasm of the invasive cells. The lesion may be localized and only superficially invasive or deeply invasive and have a g... | 182,351 | [
-0.1835871,
-0.1932329,
-0.3869564,
0.2349024,
-0.0236391,
-0.3433767,
0.03717737,
0.05662348,
0.3055877,
0.01067129,
0.01045078,
-0.01003521,
-0.2148329,
0.251777,
-0.1576211,
-0.1458671,
-0.2982338,
-0.08354656,
0.1886007,
-0.2232872,
0.3645008,
0.2263585,
-0.1903436,
... |
Recurrent cystosarcoma phyllodes: a clinicopathologic study of 32 cases. | A retrospective study was made of recurrent mammary cystosarcoma phyllodes seen at Memorial Sloan-Kettering Cancer Center from 1932 to 1972. Clinicopathologic findings, clinical course, treatment, and survival are described. It is apparent that cystosarcomas may recur and several years may elapse between reucrrences. W... | 182,356 | [
-0.1025399,
-0.1808189,
-0.098464,
-0.459758,
-0.03844946,
-0.23527,
-0.1178007,
-0.1795789,
0.09123857,
0.06713308,
0.1292518,
0.4354844,
0.1088335,
0.09156291,
-0.05508834,
-0.3570124,
0.2292277,
-0.06108917,
0.3278042,
-0.01744886,
0.1938407,
0.2714883,
-0.05876365,
... |
The selection of virus-resistant Chinese hamster ovary cells. | We have selected Chinese hamster ovary (CHO) cells resistant to infection by encephalomycarditis (EMC) virus. Thus far, we have obtained five lines resistant to EMC, all of which manifest different phenotypes. Three of the five are not persistently infected with virus, while two lines produce infectious virus and grow ... | 182,382 | [
-0.01134606,
-0.1029219,
-0.07254479,
-0.4211198,
0.03105311,
-0.08866147,
-0.1434181,
-0.006899611,
0.0587022,
-0.0209604,
0.1174644,
-0.0172057,
0.02695248,
0.2463513,
-0.3539643,
-0.1927921,
-0.408405,
0.1645936,
-0.1857587,
0.437553,
0.06730423,
-0.02687784,
-0.001245... |
Arenavirus taxonomy: a review. | Despite a late beginning, the construction of the arenavirus taxon and its placement in the scheme of the International Committee on Taxonomy of Viruses has now been completed. The bringing together of the member viruses has already provided valuable indications of promising laboratory and field study approaches; in th... | 182,395 | [
-0.1751426,
0.05269927,
0.04299891,
0.05538619,
0.05983857,
-0.1960957,
-0.1296542,
-0.05476007,
0.004943216,
-0.06658996,
0.08431493,
-0.4244381,
0.1782514,
-0.1922779,
-0.4752193,
-0.2852155,
-0.006321898,
0.1215368,
0.2607722,
0.1292986,
-0.04110013,
0.1543033,
-0.2020... |
Antigenic properties of the arenaviruses. | Arenaviruses are known to show antigenic relationships in the complement-fixation (CF) and fluorescent antibody tests but not in the neutralization test. The humoral response to some of the arenaviruses is characterized by a dissociation between the antibodies determined by the CF test and those determined by the neutr... | 182,397 | [
0.1847586,
-0.001088436,
0.08859345,
0.03034196,
-0.1132714,
0.3243273,
-0.2965352,
-0.01816967,
0.3994231,
-0.05132338,
0.0633406,
-0.08859581,
0.3680515,
-0.1461858,
-0.4915147,
-0.4688055,
-0.1347549,
0.2858329,
0.149111,
0.4792296,
0.2193979,
-0.3026341,
-0.3194031,
... |
Protection of monkeys against Machupo virus by the passive administration of Bolivian haemorrhagic fever immunoglobulin (human origin). | Bolivian haemorrhagic fever immunoglobulin of human origin, given either prior to or shortly after experimental infection with Machupo virus, protected rhesus and cynomolgus monkeys against initial clinical illness. Some survivors developed severe neurological signs 30-47 days after virus inoculation and died 4-6 days ... | 182,406 | [
-0.179173,
-0.0293052,
-0.2789022,
-0.214032,
-0.005577578,
-0.04315186,
-0.1473709,
-0.1661402,
-0.2345952,
-0.03215007,
0.1694102,
0.0699434,
0.2277902,
-0.2086388,
-0.3208013,
-0.2556803,
-0.2750831,
0.1816576,
-0.09852403,
0.3147078,
0.08793803,
0.1048439,
-0.09329206... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.