title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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[Researches on the water quality of the river Po and its tributaries between Cremona and Casalmaggiore. I. materials and methods (author's transl)]. | During 1971 a research program about the status of pollution of the river Po and its tributaries was started by six Institutes of Hygiene altogether (Turin, Pavia, Milan, Parma, Modena and Ferrara Universities) with the Institute for Water Research of C.N.R. and Hydrographic Office of Magistracy of the Po. The role of ... | 189,776 | [
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Lecithin: cholesterol acyl transfer rate in plasma and its relation to lipid and lipoprotein concentrations in primary hyperlipidemia. | Plasma lecithin: cholesterol acyl transfer (LCAT) rate and concentrations of lipids in plasma and lipoproteins were studied in 107 hyperlipidemic subjects. In all types of hyperlipoproteinemia LCAT rates were higher than in a normolipidemic reference group. LCAT rates were highest in type IV and V. There was a consider... | 189,784 | [
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Sero-epidemiological survey on human and swine influenza A. Situation at the onset of summer 1976. | A serological survey was performed to detect the presence of HI antibodies against the swine-like A/New Jersey/76 (Hsw1 N1) and the human A/Victoria 3/75 (H3N2) virus strains in the sera of 700 subjects of different age, and of 244 swine. HI antibodies against A/New Jersey/76 strain were not detected in 308 subjects yo... | 189,788 | [
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Binding of allosteric effectors to carbamyl-phosphate synthetase from Escherichia coli. | The binding of ornithine and inosine 5'-monophosphate (IMP), positive allosteric effectors, and of uridine 5'-monophosphate (UMP), a negative allosteric effector, to carbamyl-phosphate synthetase from Escherichia coli was studied by the technique of equilibrium dialysis. The monomeric form of the enzyme has one binding... | 189,806 | [
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Actinomycin D complexes with oligonucleotides as models for the binding of the drug to DNA. Paramagnetic induced relaxation experiments on drug-nucleic acid complexes. | Mn(II) ions have been used as a paramagnetic probe to investigate the geometry of drug-oligonucleotide complexes. Nuclear magnetic resonance and electron spin resonance experiments show that Mn(II) ions bind approximately two orders of magnitude stronger to the 5'-terminal phosphate group than to the 3'-5' phosphodiest... | 189,809 | [
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Magnetic resonance study of the distribution of 2,2,6,6-tetramethylpiperidine-N-oxyl in phosphatidylcholine bilayers. | With the aid of paramagentic praseodymium ions the resonances at 60 MHz of the inward and outward facing choline methyl protons of sonicated egg yolk phosphatidylcholine vesicles were resolved. The subsequent addition of 2,2,6,6,-tetramethylpiperidine-N-oxyl (TEMPO) to the vesicle suspension broadened the inner and out... | 189,814 | [
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Ligand-induced conformational changes in spin label-modified human hemoglobins and chains and their carboxypeptidase A-digested derivatives. | The reactive sulfhydryls of human adult and fetal hemoglobin and the single sulfhydryl of isolated gamma chains have been spin labeled with N-(1-oxyl-2,2,5,5-tetramethyl-3-pyrrolidinyl) iodoacetamide. Similar electron paramagnetic spectral differences between oxy- and deoxy-modified hemoglobins were observed for both t... | 189,824 | [
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The application of ESR to chromatin. Spin-labelling of the histone H3 cysteine residues in situ. | The possibility has been investigated of selectively spin-labelling the cysteine residues of histone H3 in chromatin and probing by ESR conformational changes affecting the labelled area as the molecular environment is altered. About 90% of bound labels are attached to the thiol groups and are strongly immobilized in d... | 189,826 | [
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Spectroscopic studies of the oxidation-reduction properties of three forms of ferredoxin from Desulphovibrio gigas. | Electron paramagnetic resonance spectra were recorded of three forms of Desulphovibrio gigas ferredoxin, FdI, FdI' and FdII. The g = 1.94 signal seen in dithionite-reduced samples is strong in FdI, weaker in FdI' and very small in FdII. The g = 2.02 signal in the oxidized proteins is weak in FdI and strongest in FdII. ... | 189,829 | [
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Immunoassay for honey bee cytochrome c in single animals with cytochrome c-coated bacteriophages: a sensitive tool for the study of caste formation in the honey bee, Apis mellifera. | The development of a sensitive viroimmunoassay for honey bee cytochrome c and its usage for early detection of caste differentiation is described. Pure honey bee cytochrome c was isolated from workers and used to produce antibodies in rabbits. Bacteriophage T4 was chemically modified by covalent attachment of honey bee... | 189,841 | [
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Distribution of angiotensin II receptors in rat brain. | Angiotensin II binding activity of rat brain particles was examined using [125I]-angiotensin II (0.1-0.3 nM) in the presence and absence of excess unlabelled angiotensin II. Certain features of the binding suggested that physiological receptors were involved. The binding activity was temperature dependent and was incre... | 189,877 | [
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Fractionation of human low density lipoprotein by column chromatography. | We have devised a method to fractionate low density lipoprotein (LDL) into subspecies by means of column chromatography. DEAE-agarose columns, 2.6 X 60 cm, were loaded with LDL (25-45 mg LDL protein) and eluted with a 0.045-0.13 M NaCl gradient. The LDL eluted over a volume of 900 ml. Specific portions of the eluted LD... | 189,881 | [
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The role of metabolic energy in the lethal action of basic proteins on Candida albicans. | Comparative studies were made on the destructive effects of certain basic proteins on a strain of Candida albicans and two of its respiration-impaired mutants. Both by direct plate counts of survivors and by quantitative ultraviolet spectrophotometric analyses of released cellular constituents, the respiration-impaired... | 189,885 | [
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Malignant mixed tumor of salivary origin: a clinicopathologic study of 146 cases. | A 30-year Memorial Hospital experience with 146 patients with malignant mixed tumor is reviewed. These comprised 5% of 2,743 patients who were treated for salivary neoplasms from 1939 through 1968. The tumors arose in the parotid gland in 108 patients, submaxillary gland in 23 patients, mucus or so-called minor salivar... | 189,890 | [
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Expression of SV40 T antigen during inhibition of DNA synthesis. | Treatment of human SV40-transformed cells with excess thymidine or cytosine arabinoside caused a rapid decrease in the expression of T antigen as determined by quantitative immunofluorimetry. | 189,902 | [
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Enhancement of diethylnitrosamine hepatocarcinogenesis in rats by exposure to polychlorinated biphenyls or phenobarbital. | Diethylnitrosamine (DENA) hepatocarcinogenesis was enhanced by sequential exposure with polychlorinated biphenyls (PCBs) and with phenobarbital. This was shown by the earlier appearance of tumors and a significant increase in the number of tumors. However, there was no evidence suggesting an acceleration of tumor growt... | 189,905 | [
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The effect of the phorbol ester tumor promoters on the basal and catecholamine-stimulated levels of cyclic adenosine 3':5'-monophosphate in mouse skin and epidermis in vivo. | To measure the in vivo levels of cyclic adenosine 3':5'-monophosphate (cyclic AMP) in mouse skin, precautions must be taken to avoid artifactual alterations after excision of the skin from the mouse. With such precautions, the level of cyclic AMP in mouse epidermal-dermal preparations was unchanged 1 to 18 hr after app... | 189,908 | [
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Neuronal cytoplasmic inclusions in the dorsal horn and supraoptic nucleus of the squirrel monkey, Saimiri sciureus. | In the squirrel monkey (Saimiri sciureus) two types of cytoplasmic inclusion bodies have been observed sporadically in neurons of both the dorsal horn (Rexed's laminae I-III in the lumbosacral region) and the supraoptic nucleus. One of these, designated here the "vesicular body", is a round inclusion which measures up ... | 189,928 | [
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[Changes in the concentration of biogenic monoamines in different brain regions under the influence of centrophenoxine (experiments on rats)]. | The authors administered 50 mg/body weight of centrophenoxine in white rats i.p. for five susseccive days. The content of serotonine in the cerebral cortex, brain stem and cerebellum increased statistically significant in the rats, injected with centrophenoxine. The levels of noradrenaline and dopamine in the brain ste... | 189,988 | [
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Evidence for the identity of nuclear and cytoplasmic adenosine-3':5'-monophosphate-dependent protein kinase from porcine ovaries and nuclear translocation of the cytoplasmic enzyme. | Protein phosphokinase activity from a 0.5 M NaCl extract of purified porcine ovary nuclei has been resolved by Sephadex G-200 gel filtration into three forms of kinase, protein kinase I and III, both independent of adenosine 3':5'-monophosphate (cyclic AMP), and cyclic-AMP-dependent protein kinase II. Cyclic AMP-bindin... | 190,008 | [
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Cyclic nucleotide phosphodiesterases from rat anterior pituitary. Characterization of multiple forms and regulation by protein activator and Ca+. | Phosphodiesterase activities for adenosine and guanosine 3':5'-monophosphates (cyclic AMP and cyclic GMP) were demonstrated in particulate and soluble fractions of rat anterior pituitary gland. Both fractions contained higher activity for cyclic GMP hydrolysis than that for cyclic AMP hydrolysis when these activities w... | 190,011 | [
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Estrogen receptor in breast cancer of the Japanese. | The estrogen receptor was assayed, using the 2,000g supernatant and dextran-coated charcoal method, in 243 tissue samples from human breast cancer, benign breast diseases, macroscopically normal breast tissues, normal uterine myometrium, and uterine myoma. The estrogen receptor was found to be positive in 52.1% of 98 p... | 190,078 | [
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Effect of iron-beryllium antagonism on the growth of Pseudomonas fluorescens type S. | Studies of the growth of Pseudomonas fluorescens type S in acidified peptone nutrient broth supplemented with potassium dioxalatoberyllate show that the inhibitory action of beryllium on the lag phase can be strongly counteracted by an increase in the iron content of the medium. In terms of relative concentrations, Fe3... | 190,091 | [
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Protein synthesis in postnuclear supernatants from mengovirus-infected Ehrlich ascites tumor cells. | The effect of mengovirus infection on the protein synthetic capacity of Ehrlich ascites tumor cells cultured in vitro was studied in vivo and in vitro employing postnuclear supernatants prepared at various times post-infection in the absence and in the presence of 1% Triton X-100. The amino acid incorporating activitie... | 190,103 | [
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Options for care of the aged sick. | Hospital workups should be done only when they will produce information not otherwise obtainable. Even when patients are acutely ill, home care may be preferable; after care and day care are often best for long-term treatment. | 190,109 | [
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Latent genomes of Epstein-Barr virus. | Of the EBV DNAs in Raji cells that contained 50 to 60 viral genomes per cell, 90% were separated from high molecular weight cellular DNA by centrifugation in a neutral glycerol gradient after lysis of the cells by treatment with pronase and Sarkosyl, indicating that the major portion of the EBV DNA in Raji cells was no... | 190,114 | [
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Immunological studies with hamster cells transformed by cytomegalovirus and herpes simplex virus type 1. | Evidence is presented that cells transformed by CMV and HSV-1 express virus-associated antigens on the cell surface. The finding that hyper-immune antivirus sera block cellular immunity in vitro may explain why virus-immunized hosts have thus far not been found to reject isografts of these cells. | 190,134 | [
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Detection of Epstein-Barr virus early antigen-D and its antibodies by passive hemagglutination. | These data describe the use of a passive hemagglutination test (PHAT) for the detection of antibodies to the Epstein-Barr virus (EBV) associated antigen, early antigen-D (EA-D). EA-D was obtained from EBV-superinfected RPMI 64-10 cell preparations which showed by immunofluorescent staining (IF) that 25-35% of the cells... | 190,173 | [
0.004440166,
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... |
Expression of genes for metabolism of cyclic adenosine 3':5'-monophosphate in somatic cells. beta-Adrenergic and PGE1 receptors in parental and hybrid cells. | Using the ligands [125I]iodohydroxybenzylpindolol and [3H]prostaglandin E1 ([3H]PGE1), we have studied the relationship of receptors for beta-adrenergic agents and for PGE1 to adenylate cyclase in membranes of parental, hybrid, and variant mammalian cell lines. Fusion of parental clones responsive to beta-adrenergic ag... | 190,227 | [
-0.1987856,
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0.5952437,
0.2996118,
0.2092344,
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0.030444... |
Ultrastructural changes induced by ACTH in normal adrenocortical cells in culture. | The effects of ACTH, its o-nitrophenyl sulfenyl derivative (NPS-ACTH) and dibutyryl cyclic AMP (dbc AMP) on the ultrastructural morphology of adrenocortical cells of adult rats in monolayer culture have been investigated. NPS-ACTH, which has previously been shown to stimulate steroidogenesis but not cAMP synthesis in a... | 190,242 | [
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0.1540651,
0.1938842,
0.3442619,
-0.0259696,
-0.01795414... |
Micro-determination of total phthalate esters in biological samples by gas-liquid chromatography. | A method was investigated in which all of the phthalate esters in biological samples were determined as phthalic acid by gas-liquid chromatography. The method is based on the separation of phthalate esters from the sample with n-hexane, saponification of the esters with an alkaline ethanolic solution to give phthalic a... | 190,247 | [
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0.2034624,
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Plasma pregnenolone and 17-OH-pregnenolone in patients with adrenal tumors, ACTH excess, or idiopathic hirsutism. | Plasma levels of the delta5-pregnenes, pregenolone and 17-OH-pregnenolone, were measured in patients with disordered steroidogenesis. While 17-OH-pregnenolone was within the normal range in patients with hypercortisolemia due to Cushing's disease, ectopic ACTH or adrenal adenrenal adenoma, 4 of 6 patients with an adren... | 190,251 | [
-0.3270059,
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0.3450552,
0.258681,
-0.04771167... |
Response of several adrenal steroids to ACTH stimulation in essential hypertension. | Plasma concentrations of progesterone (P), deoxycorticosterone (DOC), 17-hydroxyprogesterone (17-OH P), corticosterone (B), deoxycortisol (S), cortisol (F), and aldosterone were measured in 8 control subjects and in 10 patients with low and normal renin essential hypertension (EH) before and 4 and 8 h after an iv infus... | 190,252 | [
-0.2810982,
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0.1944051,
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0.3670811,
0.1958035,
0.2785184,
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-0.09... |
Plasma ACTH and cortisol responses to TRF, vasopressin or hypoglycemia in cushing's disease and nelson's syndrome. | The response of plasma ACTH and/or cortisol concentrations to thyrotropin-releasing-factor (TRF), vasopressin, and insulin administration was determined in 5 patients with Nelson's syndrome and 12 patients with untreated Cushing's disease. TRF administration was associated with a mean increment of 267 pg/ml in plasma ... | 190,254 | [
-0.2214459,
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0.234169,
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0.2487154,
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0.2263051,
0.1251604,
0.3553306,
0.05532311,
0.1081105,
-0.086... |
Characteristics of high molecular weight insulins in insulinoma patients. | These studies were undertaken to characterize the high molecular weight immunoreactive insulins in plasma and tumor extracts of two patients with insulinoma, and to determine whether they are biosynthetic precursors of proinsulin. Plasma was chromatographed on a Sephadex G-50 column and fractions assayed for IRI. Three... | 190,261 | [
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0.07887906,
0.1772972,
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... |
Proposed calfhood immunization program for the commercial dairy herd. | Immunization programs never will usurp the central role of sound management practices and good nutrition in the disease prevention program of the commercial dairy operation. However, certain immunizations against diseases such as brucellosis, leptospirosis, and clostridial infections should be routine. Other diseases s... | 190,280 | [
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0.3511845,
-0.03428... |
Regulation of protein kinase in rat pineal: increased Vmax in supersensitive glands. | Protein kinase activity was examined in supernatants from super-sensitive and subsensitive rat pineal glands both in the presence and absence of added cAMP. After a 20 min exposure to 1-isoproterenol, in vivo or in organ culture, supersensitive pineals displayed a greater decrease in protein kinase activity (in the abs... | 190,278 | [
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0.4003085,
0.1297981,
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0.257484... |
Isolation and characterization of immunoregulatory factors from normal human serum. I. Preliminary biochemical and biological characterization of immunosuppressive factors. | Normal human serum was shown to inhibit the mitogenic effects of bacterial lipopolysaccharide and Con A on mouse spleen lymphocytes and reduce the in vitro antibody response to SRBC by these cells. Furthermore, it was demonstrated that immune suppression occurred without loss of lymphocyte viability. Fractionation of n... | 190,315 | [
0.181603,
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0.006023557,
0.472623,
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0.3022506,
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... |
Solid-phase radioimmunoassay of herpes simplex virus IgG and IgM antibodies. | A solid-phase radioimmunoassay for detection of herpes simplex virus-specific IgG and IgM antibodies in human serum specimens is presented. Virus antigen is adsorbed on polystyrene balls and antibodies which attach to the antigen are detected by 125I-labeled antihuman-gamma or antihuman-mu immunoglobulins. A total of 7... | 190,320 | [
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0.3424837,
0.613941,
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Effects of topical prostaglandin E analogue on normal hairless mouse epidermal DNA synthesis. | The in vivo topical effects of a synthetic analogue of prostaglandin E2 (15(S)-15-methyl PGE2 methyl ester [PGE2 analogue]), have been studied on the epidermis of hairless mice. One microgram of the PGE2 analogue increased DNA synthesis significantly by 5 hr, a maximum increase of 390% was reached by 12 hr, and DNA syn... | 190,328 | [
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0.435608,
0.2471778,
0.1089265,
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-0.2649... |
Calcium-activated conductance in skate electroreceptors: current clamp experiments. | When current clamped, skate electroreceptor epithelium produces large action potentials in response to stimuli that depolarize the lumenal faces of the receptor cells. With increasing stimulus strength these action potentials become prolonged. When the peak voltage exceeds about 140 mV the repolarizing phase is blocked... | 190,338 | [
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0.2396098,
0.2050771,
0.... |
Characterization of the Drosophila C virus. | Some properties of Drosophila C virus (DCV), a non-occluded isometric virus, have been studied. The virus particles were 30 nm in diam., their sedimentation coefficient was 153S and their buoyant density was 1-34 g/ml in caesium chloride in the pH range 7 to 9. These particles contained about 31% ribonucleic acid (RNA)... | 190,345 | [
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0.19717,
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0.1932066,
0.04338264,
-0.1720553... |
An ultrastructural study of chronic sodium cyanate-indiuced neuropathy. | Fifteen rats were given a sodium cyanate-rich diet for 18 months and at the end of that period, all of them had developed motor weakness and were perfused for ultrastructural study. A peripheral neuropathy involving mostly the roots and sciatic nerves was found and the main ultrastructural lesion was vacuolization of m... | 190,359 | [
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0.01984192,
0.1805803,
0.1965901,
... |
Technetium-99m-Sn-pyrophosphate pharmaco-kinetics and bone image changes in parathyroid disease. | Skeletal abnormalities in 12 patients with primary hyperparathyroidism, five patients with pseudohypoparathyroidism, and three patients with hypoparathyroidism were studied to compare the diagnostic sensitivity of bone radiologic examination to that of radionuclide studies using 99mTc-Sn-pyrophosphate (99mTc-PPi) a ske... | 190,364 | [
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0.1278763,
0.2467739,
0.3278575,
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... |
The presynaptic site of action of norepinephrine in the superior cervical ganglion of guinea pig. | Supramaximal preganglionic volleys did not elicit detectable postsynaptic potential in the curare-treated superior cervical ganglion cell of the guinea pig whereas, a tetanic stimulation (10-30 Hz, 1-5 seconds) consistently evoked a monophasic depolarizing potential resembling the slow excitatory postsynaptic potential... | 190,378 | [
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0.2935244,
... |
Dual effects of hemicholinium-3 at central cholinergic synapses. | 1. Hemicholinium-3 (HC-3) has at least two presynaptic effects at cholinergic synapses between motor acon collaterals and spinal Renshaw cells, neither of which influenced non-cholinergic excitatory synapses on dorsal horn interneurones. 2. One, which occurred independently of repetitive activity of the synapses and wh... | 190,385 | [
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Assay of pertussis vaccine toxicity by a rat-paw-oedema method. | A method is described of using the production of oedema in the foot pad of rats as an index of the ability of pertussis vaccines to cause local reactions. At a suitable time after the subcutaneous injection of the vaccine into hind paw of the rat, the foot is excised and weighed. The technique is reproducible and most ... | 190,401 | [
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0.2272822,
0.1958504,
... |
Temperature-sensitive variants for saturation density and anchorage dependencey of a simian virus 40-transformed human X mouse hybrid cell line. | Several variant clones temperature sensitive for some parameters of transformation from a hybrid cell line containing a stable diploid mouse genome and two human chromosomes 7 carrying an integrated defective simian virus 40 have been isolated. Like the wild-type (wt) cells, at the permissive temperature the temperatur... | 190,414 | [
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0.1588949,
0.2898073,
0.1210871,
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0.034... |
Preparation of cell-free feline oncornavirus-associated cell membrane antigen. | Cell-free feline oncornavirus-associated cell membrane antigen (FOCMA) was prepared from a feline lymphoblastoid cell line of tumor origin (FL-74). Membrane fractions, separated on sucrose density gradients, and papain-solubilized products were found to contain FOCMA as determined by their capacity to inhibit reference... | 190,418 | [
-0.4486443,
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0.07212625,
0.2308218,
-0.01732195,
-0.4877588... |
Sertoli-Leydig cell tumor in a chimpanzee. | Microscopic analysis of a 38-year-old chimpanzee (Pan troglodytes) revealed a well differentiated Sertoli-Leydig cell tumor (arrhenoblastoma), 4 mm in diameter. Extensive follicular atresia and thecal hypertrophy were noted. The endometrium showed extensive adenomatous hyperplasia, an indication of hyperestrinism. It w... | 190,468 | [
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0.08195835,
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0.02192572,
0.1076434,
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0.1497139,
0.3943397,
-0.06665152,... |
Transpalatal approach to deeper cranial structures. | The approach to deep midline cranial structures is technically difficult. The transpalatal approach has a relatively wide exposure as compared to the transnasal, transantral and transethmoidal approches. The added advantage of a medial approach which follows medial landmarks and the flexibility of being able to extend ... | 190,493 | [
-0.1629591,
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0.1289252,
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-0.1327079,
-0.097... |
[The relation of infection with the hepatitis B-agent to primary hepatic carcinoma (author's transl)]. | In Asia, Africa and other tropical areas primary hepatic carcinoma (PHC) is associated with liver cirrhosis of the post-necrotic (macronodular) type. Chronic viral hepatitis is likely to be the cause of this cirrhosis in many patients from regions where chronic infection with the hepatitis B virus (HBV) is common. More... | 190,499 | [
0.134671,
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0.3450092,
0.1437673,
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0... |
A gal region mutant that requires cAMP for growth on galactose in an adenyl cyclase negative (cya delta) background. | Strains of Escherichia coli K12 that contain a deletion of the adenyl cyclase gen (cya delta), required for the synthesis of cyclic adenosine-3';5' monophosphate (cAMP), grow on galactose-containing minimal medium. A mutant was isolated that grows on this medium only if cAMP is added. The mutation (designated galP20) i... | 190,530 | [
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0.04088509,
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0.4807548,
-0.09191439,
-0.150343... |
Mucin-producing cholangiocarcinoma: an autopsy study in Hong Kong. | Fifty autopsy cases (35 male and 15 female) of mucin-secreting cholangiocarcinoma in Chinese were reviewed. The peak incidence was in the 7th decade for males and in the 6th for females. Massive (37), multinodular (8), diffuse (1) and hilar (4) types were recognized grossly. The hilar tumours arose from the main intrah... | 190,576 | [
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0.1862788,
0.1125082,
-0.07300769,... |
Effect of ultraviolet light and oral vitamin D3 on rachitic chicks fed diets containing either corn or rye. | Three experiments using day-old chicks were conducted in battery brooders to further study the rye-vitamin D antagonism. Birds were fed a vitamin D3-free diet containing corn or rye and submitted to diverse treatments for the first 10 days. At this time the chicks were either continued on the same diet or changed to ot... | 190,600 | [
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... |
Gemfibrozil: effect on serum lipids, lipoproteins, postheparin plasma lipase activities and glucose tolerance in primary hypertriglyceridaemia. | The hypolipidaemic effect of a new drug, gemfibrozil (CI-719), was studied for 20 weeks in 20 patients with primary type IIb, III, IV or V hyperlipoproteinaemia. Baseline recordings of serum cholesterol (9.1 mmol/l), triglyceride (3.79 mmol/l) and ultra-centrifugally isolated lipoproteins were obtained during a six-wee... | 190,608 | [
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0.01042152,
... |
Lipokinetic studies with gemfibrozil (CI-719). | Gemfibrozil (CI-719) has proved to be an effective agent in reducing the plasma triglyceride levels in experimental animals and in patients with endogenous hypertriglyceridaemia. We have confirmed these findings. | 190,610 | [
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[The diagnostic value of the determination of cyclic 3',5'-adenosine monophosphate (cAMP) in urine]. | Many hormones initiate their biologic actions by augmenting the intracellular concentrations of 3',5'-adenosine monophosphate (cyclic AMP). The nucleotide has been found in body fluids; its determination in plasma and urine can be performed by a rapid, simple and specific method: the cyclic AMP assay kit of the Radioch... | 190,633 | [
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0.1... |
Superhelix densities of circular DNA's: a generalized equation for their determination by the bouyant method. | Equations for the measurement of the supertwisting of circular DNA's from banding positions in buoyant density gradients containing intercalating dyes have required the use of SV40 DNA isolated from virions as a reference DNA. These equations are modified to allow the use of any closed circular DNA of known superhelix ... | 190,680 | [
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Amplitude spectrum representation in the Doppler-shifted-CF processing area of the auditory cortex of the mustache bat. | The mustache bat, Pteronotus parnellii rubiginosus, emits orientation sounds containing a long constant-frequency (CF) component that is ideal for echo detection and Doppler shift measurement. About 30 percent of the primary auditory cortex of this bat is chiefly devoted to processing the second harmonic of the CF comp... | 190,681 | [
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[Mental disorders in the elderly]. | In the psychopathology of old age, one should avoid a pessimistic attitude in therapeutics. A multidimensional approach will permit understanding of the psychological decompensation in old age, and the drawing up of coherent therapeutic plans which are often efficacious. | 190,693 | [
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0.02695493,
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Acute silicoproteinosis. | A case of alveolar lipoproteinosis associated with silicosis is reported. A 58-year-old man had been exposed to silica for seven years and died three years after the onset of symptoms. Light microscopy of biopsy and necropsy material showed small silicotic nodules, silica particles, and alveolar lipoproteinosis, and ul... | 190,727 | [
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... |
Simultaneous nosocomial and community outbreak of epidemic keratoconjunctivitis with types 8 and 19 adenovirus. | In a simultaneous community and nosocomial (hospital-based) epidemic of keratoconjunctivitis lasting one year, 97 patients had clinical findings characteristic of EKC. Seventy-one percent of the cases were confirmed by laboratory tests including viral isolation, antibody response detected by complement fixation and hem... | 190,749 | [
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0.13439... |
[Kinetics of cell proliferation and growth of transplanted hepatoma in mice]. | The authors compared the parameters of the growth and kinetics of the cell proliferation of five strains of transplantable mice hepatoma. By means of autoradiography and 3H-thymidine the curves of labeled mitoses and these of persistently labeled cells were obtained and analysed. Of all the mitotic cycle parameters: th... | 190,795 | [
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0... |
[Radiotherapy of Nephroblastoma (author's transl)]. | The treatment methods for the differnt stages of the disease are discussed. The tumour is irradiated preoperatively. Intraoperatively, chemotherapy is commenced and, depending on the stage of the disease, radiotherapy is continued with chemotherapy. In stages III and IV and, if metastases occur, extended fields are irr... | 190,802 | [
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Quantity of antibody synthesized in a single cell during the primary immune response. | Following immunization of mice with SRBC the kinetics of antibody synthesis by individual immunocompetent cells during the primary immune response were investigated. The diameter of the average hemolytic plaque using a modified Jerne plaquing technique, was taken to be an estimate of the antibody production by a single... | 190,809 | [
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[Sulphated glycosaminoglycans as virus inhibitors. 4th communication: clinical aspects of zoster with the proposal of a new treatment (author's transl)]. | On the base of plaque inhibition tests in at least three virus-host-systems and successful treatment of mice with experimentally induced yellow fever encephalitis a well known sulphated glycosaminoglycan (GAGPS) "L5" was used as therapeutic agent in cases of zoster infection in man. The material was applied as 1% solut... | 190,822 | [
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... |
[Influence of spontaneous arousal during hibernation of the activity of the pituitary-adrenal system in the suslik Citellus erythrogenis]. | Periodic spontaneous arousals of ground squirrels during hibernation are accompanied by activation of the hypophyseal-adrenal system. However, together with a 3-fold increase in hypophyseal ACTH and 2-fold increase in 11-oxycorticosterioid secretion by the adrenals, more than 2-fold decrease in the content of these hor... | 190,827 | [
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0.07629988,
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0.1068867,
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[Clinical and biochemical heterogenicity of phenylketonuria in adults]. | The authors carried out a clinical and biochemical investigation of 23 phenylketonuric patients at the age of 17--49 who were not treated specifically. The clinical examination showed that behavioural reactions, attacks of psychomotor excitation, neurological status, presence or absence of strokes and other symptoms of... | 190,833 | [
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Effect of vertebrate hormones on the cyclic AMP level in Tetrahymena. | Epinephrine, insulin, glucagon and theophylline produced a significant increase in the cAMP level of Tetrahymena, while the enhancing effect of TSH was not significant. The experimental results suggest that Tetrahymena possesses receptors for hormones of higher animals, but has no receptor for the nonsense hormone TSH.... | 190,836 | [
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Studies of a thyroid hormone and androgen dependent protein in rat liver cytosol. | Sodium dodecyl sulphate (SDS) polyacrylamide gel electrophoresis of the liver cytosol of euthyroid male rats revealed a prominent band (molecular weight, 26 000 daltons), designated Protein II, which was virtually absent in the cytosol of hypothyroid animals. Injection of 500 mug triiodothyronine (T3) per 100 g body we... | 190,842 | [
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Oestrogen formation from C19 precursors in human choriocarcinoma in culture. | A cloned cell line of human choriocarcinoma was evaluated as a model of human placental oestrogen production. Oestrone formation from dehydroepiandrosterone (D), D-sulphate (DS) or 4-androstenedione (A) was less than or equal to 5% of oestradiol-17beta (Oe2) formation. Oe2 formation from D and A was similar (100-150 pm... | 190,843 | [
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Corpora amylacea in the peripheral nerve axons. | Deposits similar to corpora amylacea were observed by electron microscopy within myelinated axons in the peripheral nerves in a case of familial spastic paralysis. Ultrastructurally the deposits consisted of randomly interlacing short filaments which were closely related to glycogen granules present in the periphery of... | 190,849 | [
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Effects of cholinergic drugs and imidazole on Ca release and cyclic AMP formation in microsomal fractions from rabbit colon. | Following the addition of carbachol or acetylcholine to microsomal fractions isolated from rabbit colon which were preloaded with Ca, the ions were rapidly released. In the 35-45% fraction Ca was completely released within 10 min., but in the 35% fraction only 30% was released. Carbachol reduced the adenylate cyclase a... | 190,860 | [
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Pineal serotonin metabolism in non-innervated perinatal glands before and after intraocular maturation: supersensitivity of adrenoceptors that have never been innervated. | Transplantations were made of fetal pineal glands (crown-rump length, CRL, 19-30 mm) or pineal glands from adult male rats to the anterior chamber of the eye of the rat. Studies were performed with regard to the importance of the age of the donor animal (and thereby the degree of maturation and innervation of the gland... | 190,866 | [
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The biochemistry of the renin-angiotensin system and its role in hypertension. | The renin-angiotensin system has an important role in maintaining elevated blood pressure levels in certain forms of experimental and human hypertension. Renin, an enzyme produced by the juxtaglomerular cells of the kidney, acts on a protein substrate found in the alpha 2-globulin fraction of the plasma to produce a de... | 190,880 | [
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Disulfiram toxicity and carbon disulfide poisoning. | The author compared the neurotoxic effects of disulfiram with those of carbon disulfide, a disulfiram metabolite. The results suggest that carbon disulfide is responsible for the behavioral and neurological side effects of disulfiram. If this is so, then some other toxic effects of carbon disulfide, including parkinson... | 190,907 | [
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Multicentric reticulohistiocytosis. | Multicentric reticulohistiocytosis is a rare disorder of the skin and joints that possesses distinctive histologic findings. A case is reported from shortly after its onset to a stage of resolution 4 1/2 years later. | 190,952 | [
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[Experimental reproduction of necrotic enteritis in the chicken. 2. Further mono- and polyinfections with CL. perfringens and coccidia with special reference to ground-kept chickens]. | Coccidial oocysts and/or vegetative germs, spores, and toxins of Cl. perfringens Type A were used in mono-infection and poly-infection experiments on SPF chicken aged seven and 56 days and kept under different conditions. Necrotic enteritis was regularly reproduced in all experimental groups with polyinfections. In chi... | 190,969 | [
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Tropine derivatives with central activities. Part II: Solvolysis of N-substituted nortropine methanesulfonates. | The preparation and the reaction kinetical properties in solvolysis of a series of N-substituted nortropine methanesulfonates 1-8 are described. It was found that the rate of solvolysis depends on the nature of the N-substituents considerably. The solvolysis rates can be brought into correlation with the electron donat... | 191,036 | [
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31P nuclear magnetic resonance evidence for polyphosphoinositide associated with the hydrophobic segment of glycophorin A. | Glycophorin A, the major human erythrocyte sialoglycoprotein, contains a significant amount of phosphorus when isolated by the lithium diiodosalicylate-phenol procedure. Only a small percentage (approximately 1%) of this phosphorus is phosphoprotein. 31P nuclear magnetic resonance (NMR) analysis of glycophorin A has id... | 191,066 | [
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Electron spin resonance evidence for vertical asymmetry in animal cell membranes. | Two electron spin resonance (ESR) spin labels were used to monitor the physical state of bacterial and animal cell membranes: 5N10, a nitroxide derivative of decane, and 12NS-GA, a glucosamine derivative of 12-nitroxide stearic acid. Spectra were recorded at 1 degrees C intervals from approximately 5 to 45 degrees C. A... | 191,067 | [
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-0.0496586,
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0.1476711,
0.1624563,
-0.04750981,
-0.07492574,
0.1012085,
0.04204145,
-0.383602,
-0.06135426,
-0.6743267,
0.2896083,
-0.03041675,
0.1466435,
0.199354,
0.3506292,
-0.05933472,
... |
Primary structure of mouse, rat, and guinea pig cytochrome c. | For immunochemical and evolutionary reasons we determined the primary structure of cytochrome c from two strains of laboratory mice. Thioacetylthioethane and thioacetylthioglycolic acid were used in addition to conventional reagents for sequence determinations. The sequence was found to be identical with that of the ra... | 191,069 | [
0.06848484,
-0.2569998,
-0.3501791,
0.2184334,
0.3522908,
0.1228409,
0.02033288,
0.1858713,
0.3061875,
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-0.199026,
0.008472293,
0.2377069,
-0.1139941,
-0.3408051,
-0.007403834,
0.02864951,
-0.049506,
0.2137982,
0.2887095,
0.1307981,
0.2459486,
-0.1785264,
-0.... |
Electron acceptors of photosynthetic bacterial reaction centers. Direct observation of oscillatory behaviour suggesting two closely equivalent ubiquinones. | When reaction centers are illuminated by a series of single turnover flashes ubisemiquinone is formed and destroyed on alternate flashes. This oscillatory behaviour can be observed with both optical and electron spin resonance techniques. The oscillations are dependent upon the presence of excess ubiquinone in a manner... | 191,074 | [
-0.166523,
0.08730685,
-0.2490335,
-0.2394532,
-0.1375327,
-0.3001484,
-0.2397796,
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0.1875262,
-0.1809978,
0.2390718,
0.1075553,
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-0.339081,
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-0.4352829,
0.0105132,
-0.0127849,
-0.02091614,
0.3543891,
0.1798548,
0.01562965,
... |
The effect of antibiotics on the electrical polarisability of aqueous suspensions of bacteria. | The orientation of washed Escherichia coli bacteria in suspension induced by applied a.c. electric fields has been monitored by observing the accompanying changes in the intensity of light scattered by the suspension. The data enable the anisotropy of electrical polarisability deltaalpha to be determined. Changes in de... | 191,089 | [
0.08666822,
0.1864115,
-0.1809978,
0.01653187,
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0.1273257,
0.1200438,
-0.1380463,
-0.1035345,
0.120092,
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0.3030977,
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-0.03734014,
-0.3507827,
0.05637213,
-0.254696,
0.07149092,
0.3787396,
0.09145957,
-0.01168302,
... |
[Coordinative paramagnetic enzyme centers during hormonal carcinogenesis and tumor regression under conditions of hormonal regulation]. | The ESR method was employed to study the distribution of the coordinative paramegnetic centers on the energy chain of electron transport and on the detoxifying system during carcinogenesis caused by a disturbance of the normal hormonal balance in the organism and at the tumour regression stage achieved with estrogen - ... | 191,093 | [
0.006270373,
-0.06871256,
-0.08196209,
-0.01827259,
-0.2093199,
-0.4219044,
0.1306492,
-0.1616562,
0.07346794,
0.2820102,
-0.008619688,
0.2031566,
0.06175158,
0.2578293,
-0.721494,
0.1589111,
-0.5193509,
-0.1021319,
0.173778,
0.3335622,
0.1857492,
-0.09093905,
-0.1549904,... |
[Analysis of macromolecule alkylation in tissues of intact and tumor carrying mice]. | Alkylation DNA reparation kinetics and the disintegration of alkylated RNA, proteins and lipids in liver, spleen and brain of intact and 22A hepatomic mice after a injection of 1-14C-nitrosomethylurea at a therapeutic dose are studied. The tissue studied are different in their macromolecules and lipids alkylation, in D... | 191,101 | [
-0.07418793,
-0.2432535,
-0.111805,
-0.5127584,
0.3905484,
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0.0881277,
0.2068602,
0.2180341,
0.07159524,
-0.1145947,
0.1721605,
0.1698266,
-0.3873834,
0.1414905,
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0.04392461,
-0.01706884,
0.3776993,
0.2065851,
0.07636736,
-0.1944557,
-0... |
[Changes of the phospholipid bilayer structure under the adsorption of ferricytochrome c on its surface]. | Changes in the mobility of phospholipid molecules in liposomes membranes under adsorption ferricytochrome c on its surface were studied by means of NMR and EPR spectroscopy. It is found that the interaction of cytochrome molecules with vesicles causes the broadening of 1H-NMR signals of hydrophobic as well as polar gro... | 191,102 | [
-0.1205441,
0.104139,
-0.2506486,
0.1677112,
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0.06764956,
0.1504337,
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0.0906633,
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0.02344362,
0.4558711,
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0.03855935,
-0.2587734,
0.07673573,
0.09575886,
0.09821989,
0.182373,
0.3680852,
-0.06833954,
... |
Inhibition by glucocorticoids of prostaglandin release from adipose tissue in vitro. | 1 When rabbit chopped adipose tissue was incubated with a lipolytic agent (adrenocorticotrophic hormone, ACTH1-24, 0.1 microng/ml) in Krebs solution, prostaglandin E2 was formed in the tissue and about the same amount was found in the medium. 2 In the presence of indomethacin (1 microng/ml) the appearance of prostaglan... | 191,127 | [
0.02287247,
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0.1344401,
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0.02188462,
0.1525147,
-0.1441203,
0.2029094,
-0.5037326,
0.3204129,
-0.0190396,
-0.6562166,
0.2730212,
-0.3189384,
-0.09621587,
0.06150508,
0.4225241,
0.3522834,
-0.090706,
-0.1178571,
... |
Blood-brain barrier, half-time disappearance, and brain distribution for labeled enkephalin and a potent analog. | The natural opiate methionine-enkephalin and its D-alanine2 analog were iodinated by a method involving lactoperoxidase and purified by partition chromatography on Sephadex G-25. The half-time disappearance of radioactivity was determined in blood obtained from the jugular vein after injection of the iodinated methioni... | 191,153 | [
-0.1718384,
-0.002475106,
-0.4412079,
0.003734266,
0.1155653,
-0.4317192,
-0.1967569,
-0.09126024,
0.1090319,
0.2115711,
0.04759992,
-0.02452905,
0.1748853,
-0.06849247,
-0.273885,
-0.01221066,
-0.4247589,
0.4946193,
0.09679308,
0.4541626,
0.097739,
0.1198963,
0.2009112,
... |
Temperature-induced changes in lecithin model membranes detected by novel covalent spin-labelled phospholipids. | Several spin-labelled phospholipids carrying covalently bound 5-doxylstearic acid (2-(3-carboxydecyl)-2-hexyl-4,4-dimethyl-3-oxazolidinoxyl) were intercalated in liposomes of saturated and unsaturated lecithins. Temperature-induced changes of these liposomes, detected by the spin-labelled phospholipids, were found to b... | 191,161 | [
-0.1862126,
0.01326874,
-0.09395598,
0.245804,
-0.140514,
-0.01553193,
-0.1350703,
-0.05912643,
0.350325,
0.1507815,
-0.1210405,
-0.08022053,
-0.04533377,
-0.09189219,
-0.4909704,
-0.1753377,
-0.8072351,
0.2089429,
-0.2989176,
0.2128561,
0.1858895,
0.1871894,
-0.2288676,
... |
Seroimmunity to polioviruses in an urban population of Italy. | In a seroepidemiological survey on immunity to polioviruses, carried out in Rome, neutralizing antibodies were titrated on 602 serum samples collected from individuals aged from 6 months to 88 years. The geometric mean titres were 25.24, 25.92, and 18.12 for poliovirus types 1, 2, and 3, respectively. The number of ser... | 191,208 | [
-0.1259852,
-0.41647,
-0.01669321,
-0.1190254,
-0.4312079,
-0.1130597,
-0.2403638,
0.1077364,
-0.280028,
0.1200151,
0.268356,
0.03830473,
-0.02647822,
0.004226263,
-0.2398305,
-0.6528006,
-0.1306124,
0.1997626,
-0.03894902,
0.4710824,
0.2492321,
0.3461786,
0.0179517,
-0... |
Continuity of care between the psychiatric hospital and public schools. | Seventy-five professionals from three psychiatric training hospitals were interviewed to ascertain their attitudes and stated practices concerning educational aftercare planning and implementation. Findings revealed that 75% of the professionals did not routinely contact the schools despite their acknowledgment of the ... | 191,228 | [
-0.1665092,
0.1313612,
-0.02632979,
-0.194868,
0.1831892,
-0.1588615,
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-0.3354719,
-0.2528792,
0.576644,
0.1916986,
-0.05176146,
-0.2332867,
-0.06958022,
-0.07443485,
0.09665831,
-0.04348996,
0.1409998,
-0.4767476,
-0.2558832,
0.08059312,
-0.1989616,
0.4428582,
... |
Effects of biogenic amines on the formation of adenosine 3', 5'-monophosphate in human thyroid slices. | The effects of various concentrations of biogenic amines on the formation of adenosine-3', 5'-monophosphate (cyclic AMP) and their interactions with other thyroid stimulators were investigated in human thyroid slices from normal and Graves' disease. Most of biogenic amines were found to have the stimulatory effects to ... | 191,246 | [
-0.2532077,
-0.2613076,
-0.2612359,
0.09090272,
-0.08499314,
0.1163101,
-0.275631,
0.2325064,
-0.09105317,
0.3597373,
-0.03253187,
0.3582141,
-0.1928682,
0.2798287,
-0.2879815,
0.02732603,
-0.1822484,
0.1717994,
-0.2205305,
0.3271129,
0.4008154,
0.2069296,
-0.1728657,
0... |
Binding of mouse choriomammotropin to prolactin receptors in the mouse mammary gland. | The interaction between mouse choriomammotropin and mouse mammary glands was examined by radioreceptor assays using ovine prolactin (NIH-P-S9) iodinated by lactoperoxidase as a tracer. Mouse pituitary extracts and placental extracts were subjected to 10% acrylamide gel electrophoresis. Gels were cut into 2-mm segments ... | 191,249 | [
-0.2049803,
-0.2248191,
-0.06047757,
0.0255285,
0.03582721,
-0.2037274,
0.05180945,
0.2877519,
0.3441677,
0.02788659,
-0.1787188,
-0.01148089,
0.02586586,
-0.1586319,
-0.2028467,
0.002275137,
-0.5402591,
-0.04674494,
0.1830333,
-0.03262473,
0.1339185,
0.01299892,
-0.22686... |
Physicochemical properties of T4 polynucleotide kinase. | Some physicochemical properties of T4 polynucleotide kinase (EC2.7.1.78) have been studied. The enzyme is an oligomer of one polypeptide chain. The molecular weight of the monomer is 33000, as determined from the amino acid analysis. Phenylalanine is the N-terminal amino acid. Each monomer contains two --SH groups, one... | 191,256 | [
0.04654157,
0.05144268,
-0.140851,
-0.3246608,
0.004494654,
-0.128931,
0.1119508,
0.1681415,
0.1678471,
-0.1099588,
0.17658,
0.04560933,
-0.06707813,
0.4232992,
-0.2599998,
-0.07607491,
-0.5823587,
0.05377624,
0.06276033,
0.132803,
0.5634575,
0.04926089,
-0.09129553,
0.... |
An involvement of alpha-adrenergic stimulation in exercise-induced hypoglycemia. | Hypoglycemia developed in fasted rats during forced swimming. This hypoglycemia was mostly abolished by phentolamine, an alpha-adrenolytic agent, or by hexamethonium; was potentiated by propranolol, a beta-adrenolytic agent, of by 5-methoxyindole-2-carboxylic acid, a gluconeogenic inhibitor; and was not affected by ant... | 191,260 | [
-0.3722448,
-0.0709897,
-0.3852219,
-0.479255,
0.1932455,
0.05941771,
-0.4625801,
-0.02643869,
0.08959509,
-0.2740927,
0.1368982,
0.1703126,
0.04946385,
0.0301398,
-0.2817939,
0.1357376,
-0.5565371,
0.3494908,
-0.0230297,
0.2378852,
0.1803943,
-0.008751832,
0.04665685,
... |
Rosette formation by human T and B lymphocytes in the presence of adrenergic and cholinergic drugs. | It was shown that adrenergic drugs, which increase the intracellular levels of cAMP, inhibit the rosette formation by T-lymphocytes, but stimulate the rosettes produced by B-lymphocytes. Cholinergic drugs, which increase the levels of cGMP, on the contrary, stimulate the formation of rosettes by T-lymphocytes but inhib... | 191,281 | [
-0.1602504,
-0.1027646,
-0.3643252,
-0.2188665,
0.08553956,
-0.1583092,
-0.1942486,
-0.08696491,
-0.1303096,
0.07521209,
0.02758056,
0.2233968,
-0.01013666,
0.4772652,
-0.4801498,
-0.001945124,
-0.5020974,
-0.1053906,
0.08834989,
0.3198419,
0.3718336,
0.1075664,
-0.022297... |
Snake venom action: are enzymes involved in it? | Enzymes were the first clearly recognized components of snake venoms. When several more were discovered, attempts were made to correlate venom action with enzymic functions. The last few years have seen most successful efforts in the identification, isolation and structrual elucidation of highly toxic polypeptides pres... | 191,284 | [
0.04537353,
0.0003961251,
-0.1322213,
0.1003849,
0.1664679,
-0.2781528,
-0.06602263,
0.0136146,
0.1152637,
-0.3106479,
-0.05769579,
0.02651973,
-0.2052853,
-0.09228203,
-0.4748277,
0.3537684,
-0.5031654,
0.3570626,
0.2474859,
0.09732924,
0.2509486,
0.3451605,
-0.2175453,
... |
[Studies on the thyrotropin receptor in the thyroid: positive cooperativity of Concanavalin A binding and its biphasic effects on thyroid activation induced by thyrotropin (author's transl)]. | Concanavalin A (Con A) was tested for its ability to affect thyroid activation induced by the thyroid stimulators in mouse thyroid tissues. Con A was found to have the biphasic stimulatory and inhibitory effects of thyrotropin (TSH)-induced cyclic AMP formation and endocytosis, a step in thyroid hormone secretion, in m... | 191,303 | [
-0.07793665,
-0.2819675,
-0.1570886,
0.001824875,
0.4114652,
-0.1296202,
-0.1249002,
0.1580438,
0.04558161,
0.2577562,
0.004248643,
0.251581,
-0.1551051,
-0.03496306,
-0.01082102,
0.2107087,
-0.4694371,
0.1705772,
0.2946029,
0.1746843,
0.3332025,
0.1060399,
-0.4730784,
... |
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