title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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A melanotic neuroectodermal tumor of infancy arising from the anterior fontanel. | A case of local recurrence of melanotic neuroectodermal tumor of infancy (MNT), arising from the anterior fontanel in a 6-month-old female, is presented. The follow-up of 48 months after surgery confirms the benign nature of this tumor despite its local recurrence. Clinical and histopathologic chracteristics of this ra... | 201,062 | [
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[Content of free amino acids in rabbit tissues as affected by adrenalectomy and administration of hydrocortisone and ACTH]. | Adrenalectomy is accompanied by a decreased content of free amino acids in muscules and blood plasma by an increased content of certain amino acids in the liver. A single injection of hydrocortisone to adrenalectomized animals increases the content of amino acids in muscles and lowers their total content in the liver; ... | 201,065 | [
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[Study of Sendai virus proteins: the proteolytic activity in the composition of the viral particles]. | Disruption of virions with non-ionic detergent induced cleavage of virus proteins in purified preparations of Sendai virus. The proteolytic activity was detected in fraction of both the soluble proteins and subvirus particles. In the fraction of soluble proteins which initially had contained glycoproteins of the viral ... | 201,101 | [
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Enzyme histochemistry of cultured ovarian cells. II. Histochemistry of porcine theca interna cells in tissue culture. | By means of histochemical technique the activities of delta53beta-, 17beta-, 20alpha-hydroxysteroid dehydrogenases and glucose-6-phosphate dehydrogenase, as well as alkaline and acid phosphatase were investigated in monolayer cultures of theca interna cells, isolated from preovulatory porcine ovarian follicles. It was ... | 201,115 | [
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Effect of salicylates on cyclic AMP in isolated rat gastric mucosa. | Studies on the cyclic AMP content of isolated rat gastric mucosa have been conducted with sodium salicylate and lysine-acetylsalicylate singly and combined with gastric secretagogues and their antagonists. Both salicylates at a concentration of 1.66 X 10(-2) M increased the amount of cyclic AMP. The increase of gastric... | 201,134 | [
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Demyelination in allergic and Marek's disease virus induced neuritis. Comparative electron microscopic studies. | Patterns of demyelination were studied in sciatic nerves, spinal roots and ganglia of chickens afflicted with either Marek's disease (MD) or experimental allergic neuritis (EAN). MD was induced in susceptible chicks after hatching by inoculation of the JM strain of MD Herpes virus. Tissues from these chickens were exam... | 201,143 | [
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Vaccination of cattle and sheep with a combined Clostridium perfringens types C and D toxoid. | Cattle and sheep (30 each) were vaccinated with a combined Clostridium perfringens type C and C perfringens type D toxoid. Vaccination and blood sample collections were made every 2 weeks over a period of 8 weeks. Increases in antitoxin titers occurred after the 2nd administration of the 2.0-ml combined product. Highes... | 201,186 | [
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Plasma adrenocorticotropin levels in normal dogs. | Plasma concentrations of adrenocorticotropin (ACTH; corticotropin) were measured in 31 normal dogs (house pets) at rest. The mean concentration was 45.77 pg/ml of blood, with individual values ranging from 17 to 98 pg/ml of blood. The measurement of this hormone secreted by the anterior lobe of the pituitary gland (ade... | 201,191 | [
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[Neurogenic stomach neoplasms induced by nitrosomethylures in Syrian hamsters]. | In the experiment with inoculation of N-nitroso-N-methylurea (a maximum total dose of 7.5 mg) to Syrian hamsters, tumors developed in 20 out of 25 animals surviving the time of the occurrence of the first tumor (31 weeks). Out of 35 tumors 17 developed at the site of inoculation: in the left cheek pouch (of them 12 emb... | 201,230 | [
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A comparison of cAMP phosphodiesterases in normal, malignant, and somatic cell hybrids. | Hybrids (PCM) between a malignant mouse lymphoma suspension cell line (P388F-36) and a normal Chinese hamster fibroblastic cell line (Ch23) have already been isolated in this laboratory. Investigations were carried out on the cAMP phospodiesterases of the parents and two of these hybrids--PCM2 and PCM3. PCM3 shows a ra... | 201,244 | [
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The equilibrium constant and the reversibility of the reaction catalysed by nicotinamide-adenine dinucleotide kinase from pigeon liver. | The reversibility of the NAD+ kinase reaction was established, and the kinetic parameters of the rate equation in the reverse direction were determined. The equilibrium constant of the reaction was determined by using the purified pigeon liver enzyme and radioactively labelled nicotinamide nucleotides. The relationship... | 201,249 | [
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Purification of cyclic 3',5'-nucleotide phosphodiesterase inhibitory protein by affinity chromatography on activator protein coupled to Sepharose. | The Ca2+-dependent, reversible, interaction of cyclic adenosine 3',5'-monophosphate (cAMP) phosphodiesterase with its activator has been used to purify the enzyme by affinity chromatography. Activator-dependent cAMP phosphodiesterase is only a minor component of the proteins specifically adsorbed in the presence of Ca2... | 201,280 | [
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Altering the specificity of restriction endonuclease: effect of replacing Mg2+ with Mn2+. | In the presence of 100 mM Tris buffer (pH 7.5) and 1-10 mM Mg2+ EcoRI endonuclease cleaves DNA at a specific nucleotide sequence and in a characteristic way: -GAATTC-. But if Mg2+ is replaced by Mn2+, the specificity of the cleavage is relaxed and cleavages occur at many other sites; moreover, there appears to be a hie... | 201,281 | [
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[Model of electrical feedback mechanisms through chemical synapses]. | The model of excitatory chemical synapse is proposed in which the feed-back between the post- and presynaptic neurones is carried out by means of synaptic current generated by postsynaptic neurone. In the model, the potential drop generated by this current along the intercellular gap near the activated synapse (RIII) e... | 201,302 | [
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[Lipid dependence of mitochondrial monoamine oxidase from rat hepatoma 27 with the use of rat liver lipid exchange proteins]. | The ability of liver lipid exchange proteins to introduce foreign phospholipids into intact mitochondria was used for a study of the lipid dependence of monoamine oxidase. Introduction of exogenous phosphatidylcholine into rat hepatoma mitochondria, in which both the monoamine oxidase activity and the phosphatidylcholi... | 201,307 | [
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[Amino acid sequence of corticotropins from seiwhale (Balaenoptera borealis) and pinwhale (Balaenoptera physalus)]. | The corticotropins from two species of whales, e. g. seiwhale (Balaenoptera borealis) and finwhale (Balaenoptera physalus) were subjected to hydrolysis by trypsin, chymotrypsin and pepsin. The peptide fragments were separated by gel-filtration through Sephadex and partition paper chromatography. The study of the amino ... | 201,308 | [
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Characterization of a myelin-related fraction (SN 4) isolated from rat forebrain at two developmental stages. | A myelin-related fraction (SN 4) was isolated from forebrain of 17- and 40-day-old rats. Fraction SN 4 was obtained as a supernatant in a slow speed differential centrifugation of a myelin fraction. In contrast to multilamellar myelin fraction, SN 4 consisted of small vesicular profiles of a mixture of single membranes... | 201,345 | [
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Presynaptic origin of penicillin after discharges at mammalian nerve terminals. | The site of origin and mechanism underlying the generation of repetitive after-discharges produced by penicillin was studied in the isolated rat phrenic nerve-hemidiaphragm preparation. Application of low concentrations of sodium penicillin to the bathing solution initiated bursts of antidromic action potentials origin... | 201,346 | [
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Establishment of an Epstein-Barr virus-negative B-cell lymphoma line from a Japanese Burkitt's lymphoma and its serial passage in hamsters. | An Epstein-Barr virus (EBV)-negative lymphoma line (JBL) was established in vitro from pleural effusion of an EBV-seropositive 29-year-old Japanese female with Burkitt's lymphoma. JBL cells as well as her original lymphoma cells bore monoclonal surface IgM with lambda light chains. The JBL line grew in single cell susp... | 201,360 | [
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Poxvirus in West African nonhuman primates: serological survey results. | Ten species of nonhuman primates in West African habitat were analysed for variolavaccinia subgroup haemagglutination-inhibition (HI) and neutralization antibodies. The animals were taken in 27 different sampling zones in parts of the Ivory Coast, Mali, and Upper Volta. Of the 195 tested, 15 (8%) had elevated HI antibo... | 201,389 | [
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Differentiation of variola, monkeypox, and vaccinia antisera by radioimmunoassay. | Poxvirus antisera adsorbed with "homologous" and "heterologous" poxvirus-infected chorioallantoic membranes (CAM) were differentiated by solid-phase radioimmunoassay (RIA). Mixtures of the antiserum dilutions and infected CAM were added directly (without centrifugation) to poxvirus-infected CAM antigens affixed to well... | 201,390 | [
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The viral etiology of acute respiratory infections in children in Uganda. | The role of viruses in respiratory diseases of young children in Uganda was studied. A viral etiology was established in 36% of the infections investigated. The most important pathogens were found to be respiratory syncytial virus and parainfluenza viruses, which were responsible for 26% of infections investigated. The... | 201,391 | [
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E-rosette inhibiting substance in Hodgkin's disease spleen extracts. | Patients with Hodgkin's disease often manifest impairment of cell-mediated immune responses in both in vivo and in vitro tests, as well as a markedly decreased percentage of E rosette-forming (T) lymphocytes in the peripheral blood. This report describes the inhibition of E-rosette formation by normal peripheral blood ... | 201,408 | [
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Effect of vitamin D3 on duodenal absorptive cell plasma membranes: freeze fracture replication study. | Vitamin D3 induced changes in the number of 5.8 nm sized randomly scattered particles on the EF faces of plasma membranes of chick duodenal absorptive cells. Their number increased as compared to those in rachitic animals. Also vitamin D3 seemed to alter the nature of the zonula occludens. These changes appear to be re... | 201,433 | [
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Inhibition of cortiocosteroidogenesis by delta-9-tetrahydrocannabinol. | ACTH, cholera toxin, cyclic AMP but not pregnenolone-induced steroidogenesis in Y-1 functional mouse adrenal tumor cells was significantly inhibited by delta-9-tetrahydrocannabinol, cannabidiol, and cannabinol. The inhibition of steroidogenesis could not be correlated with a general depression in cell function or viabi... | 201,449 | [
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Potent inhibitory activity of [D-Leu6, Des-Gly-NH2(10)]LHRH ethylamide on LH/hCG and PRL testicular receptor levels in the rat. | Injection of male rats with 40-200 ng of [D-Leu6, des-Gly-NH2(10)]LHRH ethylamide for 7 days caused a maximal 80% reduction of testicular LH/hCG receptor level with one injection per day being as efficient as 3 daily injections. A similar inhibitory effect was observed on testicular PRL receptors. Testis and seminal ve... | 201,452 | [
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Effect of chlorpropamide and phenformin on rat liver: the effect on plasma membrane-bound enzymes and cyclic AMP content of hepatocytes in vitro. | Chlorpropamide and phenformin inhibited (Na+ - K+)-ATPase and stimulated a high affinity cyclic AMP-phosphodiesterase of isolated liver plasma membrane when tested in vitro. In addition, the two drugs decreased the intracellular cyclic AMP content of isolated hepatocytes without being effective on plasma membrane-bound... | 201,470 | [
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Macrophage-induced reversal of immunosuppression by leukemia viruses. | Suppression of the humoral immune response by several murine leukemia viruses has been well documented. However, the mechanism of suppressed immunoresponsiveness is not well characterized. Macrophages have been reported to be intimately involved in host-tumor relationships, and were therefore examined for their role in... | 201,505 | [
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... |
[The effect of calcium on steroidogenesis in isolated human adrenal cells (author's transl)]. | The present experiment was planned to verify the effect of calcium on adenyl cyclase in isolated human adrenal cells. Normal adrenal glands were obtained surgically from patients with primary aldosteronism and advanced breast cancer. Isolated adrenal cells were prepared by the modified Haning's method. They were incuba... | 201,511 | [
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0.1099688,
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[Secretory regulation and episodic secretion of aldosterone in patients with primary aldosteronism (author's transl)]. | In nine patients with primary aldosteronism (PA), plasma aldosterone was measured in order to evaluate a role of the renin-angiotensin system, ACTH and potassium in the secretion of aldosterone. The circadian rhythm and the episodic secretion were also studied in three patients. The results were as follows: 1) In seven... | 201,513 | [
-0.1922351,
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0.01217981,
-0.05768841... |
[A case of medullary thyroid carcinoma with ectopic ACTH syndrome (author's transl)]. | A 53-year-old male with Cushing's syndrome due to ectopic ACTH production from medullary carcinoma of the thyroid was reported. The clinical course and results of detailed endocrinological studies and immunohistochemical findings about the cancer tissue were described. An abnormally high concentration of calcitonin, AC... | 201,514 | [
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... |
Isozyme patterns of branched-chain amino acid transaminase in human tissues and tumors. | The isozymes (enzymes I and III) of branched-chain amino acid transaminase (EC 2.6.1.42) from various human tissues were separated by DEAE-cellulose column chromatography. Their distributions were found to be considerably different from those in rat tissues reported before. In rats, all tissues examined contained enzym... | 201,538 | [
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0.261... |
Hyperinsulinemic hypoglycemia: effect of epinephrine suppression. | The inhibitory effect of epinephrine on basal and tolbutamide-stimulated insulin release was studied in 5 patients with hyperinsulinemic hypoglycemia. Epinephrine inhibited both basal and tolbutamide-induced insulin release in patients with beta-cell adenoma and hyperplasia, but failed to inhibit insulin release in a p... | 201,552 | [
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0.1197481,
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0.1195686,
0.2403916,
... |
EBV specific secretory IgA in saliva of NPC patients. Presence of secretory piece in epithelial malignant cells. | Saliva samples from 59 patients with nasopharyngeal carcinoma (NPC) and from 20 normal individuals were studied to determine the nature and origin of the EBV-specific IgA in NPC saliva. About 50% of NPC saliva samples contained secretory IgA specific for EBV. The corresponding tumor IgA(alpha) was found in plasma cells... | 201,574 | [
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0.5996906,
0.1769897,
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E.s.r. of spin-trapped radicals in aqueous solutions of amino acids. Reactions of the hydrated electron. | The reactions of hydrated electrons (eaq-) with amino acids were investigated by the spin-trapping method and by electron spin resonance. Tertiary nitrosobutane was used as a spin-trap to stabilize the short-lived radicals. Hydrated electrons were produced by gamma-radiolysis of de-aerated aqueous solutions of amino ac... | 201,580 | [
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... |
Reiteration frequency of feline type C viral genomes in homologous and heterologous host cell DNA. | Differences in the multiplicity of proviral sequences of two feline endogenous viruses, RD-114 and FeLV, in homologous and heterologous host DNA were examined by viral cDNA hybridization using cellular DNA fractionated with respect to reiteration frequency. The endogenous proviral DNAs in cat cells were fractionated pr... | 201,591 | [
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... |
Serum angiotensin converting enzyme in sarcoidosis: clinical significance. | The elevated activity of serum angiotensin converting enzyme (ACE) in sarcoidosis was usually reduced during steroid therapy but remained above the normal value (52 nmol-min-1-ml-1) in approximately a third of patients during the first year of therapy. ACE was elevated in 5 of 10 patients treated with steroids for at l... | 201,592 | [
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Infectious bovine rhinotracheitis: a review and update. | Infectious bovine rhinotracheitis (IBR), a herpesvirus infection of cattle, has diverse clinical manifestations. Known mainly as a respiratory tract disease characterized by tracheitis, rhinitis, and fever, IBR plays a prominent role among causes of undifferentiated bovine respiratory disease and abortion. It also caus... | 201,597 | [
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... |
Adrenocortical function in aging exercise-trained rats. | Plasma corticosterone concentrations and in vitro adrenal secretion of corticosterone were determined in exercise-trained rats. Rats, 100, 200, and 300 days of age, were trained for a 10-wk period by treadmill running. Following the training program, rats were subjected to an acute bout of swimming. Acute swimming elev... | 201,602 | [
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Hydrolytic action of phospholipases on bacterial membranes. | Substrate specificities of phospholipases C[EC 3.1.4.3] from Clostridium novyi, Clostridium perfringens, Bacillus cereus, and Pseudomonas aureofaciens were studied under the same conditions. Phospholipases C from Clostridium novyi and Bacillus cereus show wide substrate specificities while those of Clostridium perfring... | 201,610 | [
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0.4... |
Phosphodiesterase activator from rat kidney cortex. | Incubation of homogenates of rat renal cortex at 4 degrees resulted in increased cAMP phosphodiesterase activity; the increase was much more rapid in hypotonic medium than in one of physiological tonicity. cAMP phosphodiesterase activity did not increase with incubation of supernatant fractions (48,000 x g, 20 min) pre... | 201,632 | [
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Ultrastructural changes and cyclic AMP in frog oxyntic cells. | In vitro frog gastric mucosa was employed as a model for a combined physiological, biochemical, and ultrastructural study of the morphological changes which accompany the onset of acid secretion by the oxyntic cell. The histamine H2-receptor antagonist metiamide was used to provide a reproducible control state. Stimula... | 201,646 | [
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The role of butyrate in the reverse transformation reaction in mammalian cells. | The reverse transformation reaction of Chinese hamster ovary cells from compact, epithelial-like, randomly growing, heavily knobbed, lectin reactive cells into stretched, tighly adherent, smooth-surfaced, lectin resistant, fibroblast-like cells normally elicited by dibutyryl cAMP can be produced to its complete extent ... | 201,654 | [
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0.3568671,
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Effects of GTP on cyclic AMP concentrations in intact Ehrlich ascites tumor cells. | Experiments were conducted to test the hypothesis that intracellular concentrations of guanosine triphosphate (GTP) regulate the activity and hormonal sensitivity of adenylate cyclase in intact cells. By appropriate treatments, the GTP concentrations of Ehrlich ascites tumor cells could be varied between 28% and 680% o... | 201,682 | [
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... |
Dermatofibrosarcoma protuberans. | Dermatofibrosarcoma protuberans is a well-differentiated sarcoma that rarely metastasizes but is characterized by a high recurrence rate. This is due to clinically undetectable, microscopic extensions into the surrounding dermis. Chemosurgery (Mohs) is effective in the ablation of this tumor because the extensions can ... | 201,685 | [
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Autoradiographic localization of the binding of 125I-labelled prolactin to rat tissues in vitro. | The binding of 125I-labelled prolactin to normal rat tissues was examined with autoradiographic techniques. Tissue slices were incubated with 125I-labelled ovine prolactin in the presence or absence of excess unlabelled hormone to distinguish between the specific and the non-specific localization of grains. Specific bi... | 201,707 | [
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... |
Interaction of thyrotrophin with the human thyrotrophin receptor. | The relationship between the binding of thyrotrophin (TSH) to receptors and the production of cyclic AMP has been investigated using crude human thyroid membranes. Receptor binding was studied by use of 125I-labelled bovine TSH, which had been purified by adsorption to and elution from human thyroid membranes. This 125... | 201,718 | [
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Therapeutic embolisation of the external carotid arterial tree. | Intra-arterial embolisation is a valuable adjunct to the treatment of many vascular lesions, including neoplasms such as glomus tumours or juvenile angiofibromas, and arteriovenous malformations. Its place in the management of the individual patient should be established before any surgical procedure is carried out, as... | 201,731 | [
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Preoperative irradiation and chemotherapy for initially unresectable hepatoblastoma. | Three cases of hepatoblastoma that were deemed unresectable, both by angiographic study and exploration, became resectable following combined therapy of dactinomycin, vincristine, and irradiation. | 201,740 | [
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... |
Calcium requirement for activation of intact aortic smooth muscle. | 1. Elevation of [K(+)](e) induced a contraction of rabbit aorta. If 10 mM-La(3+) was applied to rabbit aortae prior to [K(+)](e) elevation no contraction occurred. When 10 mM-La(3+) was applied simultaneously with, or at short time periods after, elevation of [K(+)](e) graded contractions were obtained whose magnitudes... | 201,748 | [
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... |
1,2,4-Triazole amino nucleosides. 1-beta-D-3'-Amino-3'-deoxyribofuranosyl-1,2,4-triazole-3-carboxamide and related nucleosides. | The synthesis of 1-beta-D-3'-amino-3'-deoxyribofuranosyl-1,2,4-triazole-3-carboxamide--the 3'-amino analogue of ribavirin--and five related nucleoside analogues is described. Each analogue exhibited LD50 concentrations greater than 100 microgram/mL against P-388 mouse lymphoid leukemia cells in tissue culture. Antivira... | 201,758 | [
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0.... |
Temperature-sensitive growth regulation in one type of transformed rat cells induced by the tsa mutant of polyoma virus. | A fibroblast line of the 3T3 type with a low saturation density was established from Fisher rat embryo cells. After infection with either wild-type or tsa mutant polyoma virus, transformants were isolated and cloned at 33 degrees C on the basis of their ability either to grow as dense foci on plastic in liquid medium (... | 201,774 | [
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... |
Clinical evaluation of pivmecillinam in intractable urinary-tract infections with complications. A comparative study with amoxicillin by a randomized double-blind technique. | A comparative study was made by the double-blind technique in order to make clear the usefulness of pivmecillinam in the treatment of intractable complicated urinary-tract infections using amoxicillin as a reference drug. Pivmecillinam was given in dosage of 400 mg (potency) per day which was one-fifth the dose of amox... | 201,786 | [
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0.03298207,
0.1081877... |
The relationships between cyclic AMP, calcium and prostaglandins as second messengers. | There is considerable dissatisfaction with present second messenger hypotheses involving cyclic nucleotides and calcium. The recent findings that methyl xanthines and adenosine are prostaglandin antagonists casts doubt on much of the evidence in favour of the cyclic AMP hypothesis. There is evidence that allosteric sit... | 201,823 | [
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... |
Pars intermedia ACTH and MSH content: effect of adrenalectomy, gonadectomy and a neurotropic (noise) stress. | Pars intermedia (PI) ACTH and melanocyte-stimulating hormone (MSH) content and pars distalis (PD) ACTH concentration were measured following 3 experimentally induced 'perturbations'. The feedback-induced increase in ACTH release following adrenalectomy is not accompanied by a change in PI ACTH and MSH contents, while t... | 201,881 | [
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0.170864,
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0.0007493423,
0.03238589,
-0.0223845,
-0.0459158,
0.03597719,
-0.0674107,
0.4446023,
-0.1789482,
-0.021556... |
An investigation into the relationship of the immunological status of Herpes simplex virus type-2 (HSV-2) infected animals and the tumor-enhancing property of this infection. | In order to compare the state of immunity of HSV-2 infected animals with their sham treated counterparts, several in vivo methods for cell-mediated immunity in addition to the stimulation in vitro of mouse splenocytes with PHA were performed. The grafting of C 3 H mice with heterologous skin and the paw test with PHA s... | 201,898 | [
-0.02787294,
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0.2870505,
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0.5481579,
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0.1709576,
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[Inappropriate secretion of ADH during acute respiratory infections due to adenovirus in children (author's transl)]. | Four children aged between 7 and 19 months with severe bronchopneumonia due to adenovirus type 7, proved by virology and/or serology developed severe hyponatraemia. One of them is reported in detail: it was possible to estimate plasma ADH levels and thereby prove the existence of reversible hypersecretion of the hormon... | 201,922 | [
-0.2091987,
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0.1807588,
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0.283932,
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Capping structures of simian virus 40 19S and 16S mRNAs. | In vivo [methyl 3H]-labeled SV40 19S and 16S mRNA species were purified and their internal methylation as well as their capping structures analyzed. SV40 viral mRNA sedimenting in the 19S region contains approximately equal proportions of m7GpppAm and m7Gppm6Am, while the 16S mRNA contains mainly m7Gpppm6Am. N6 methyl ... | 201,923 | [
-0.3820746,
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0.08272652,
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0.2984255,
0.5881568,
0.06534361,
-0.04953682... |
Cytomegalovirus infection in the neonate and its prevention. | About 0.5% of infants are infected in utero with cytomegalovirus (CMV). As many as 20% become mentally retarded and a further substantial proportion suffer lesser degrees of brain damage. The need for a vaccine is greater than in the case of rubella. A live, tissue culture-adapted strain of CMV has been shown to produc... | 201,930 | [
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0.3928799,
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0.1834912,
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... |
Acute influences of some ACTH-related peptides of fighting and adrenocortical activity in male laboratory mice. | A number of corticotrophin preparations when given acutely enhanced fighting behavior, an event which may be consequent upon elevation of circulating corticosterone. A series of short ACTH analogues (ACTH 11-24, ACTH 4-10) had slight influences on circulating plasma corticosterone values and on fighting behavior. Howev... | 201,938 | [
-0.3193776,
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0.3644965,
0.01873736,
-0.08960465,
-0.167181... |
Paradoxical effects of calcium-glucagon interaction on cardiac muscle contractility of isolated guinea pig atria. | The interrelationships of calcium and glucagon, and calcium and Isuprel were investigated in spontaneous and paced isolated guinea pig atria. Positive force responses with glucagon were in part both frequency and [Ca+2]o-dependent. Negative inotropic responses were observed with high concentrations of glucagon (5.0 mic... | 201,943 | [
-0.1595769,
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0.3812962,
0.01875117,
-0.0921... |
Effect of protein kinase modulator on cAMP-dependent protein kinase-catalyzed phosphorylation of phospholamban and stimulation of calcium transport in cardiac sarcoplasmic reticulum. | The heat-stable protein (protein kinase modulator), partially purified from fresh bovine heart, possessed the ability to inhibit and stimulate adenosine 3':5'-monophosphate (cAMP)-dependent protein kinase and guanosine 3':5'-monophosphate (cGMP)-dependent protein kinase activities, respectively. The inhibitory activity... | 201,986 | [
-0.2331013,
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0.005816225,
0.3565114,
0.2330157,
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Adenylate cyclase, cyclic nucleotide phosphodiesterase, and phosphorylase activity of cardiomyopathic hamster hearts. | Activities of adenylate cyclase in homogenates were reduced, whereas those of phosphodiesterases were elevated in hearts of myopathic hamsters (BIO 82.62). Affinities for either Mg2+ or ATP of cyclase were unaffected in myopathy. Ca2+ stimulation particulate phosphodiesterases was not observed in myopathy. Although the... | 201,998 | [
-0.6099231,
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0.07684605,
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0.2318391,
0.5623869,
0.4215606,
-0.201476... |
Characterization of high density lipoproteins in human cholestasis. | High density lipoproteins (HDL) of plasma from patients with long-standing cholestasis were studied by several methods including crossed immunoelectrophoresis, gel filtration, and zonal ultracentrifugation. The crossed immunoelectrophoretic pattern against anti-HDL was characterized by the presence of several immunopre... | 202,013 | [
0.2109175,
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0.1839972,
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0.07433755,
0.04249126,... |
Adult nephroblastoma. | A case of adult nephroblastoma in a 51-year-old woman is reported. A percutaneous aspiration biopsy did not lead to the right diagnosis presumably because the histologic structure of the tumour consisted exclusively of more or less differentiated epithelial-like elements, while mesenchymal tumour components were not de... | 202,018 | [
-0.2298819,
0.2051587,
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0.008522948,
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0.4706056,
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... |
Degenerative processes in the pathogenesis of pulmonary alveolar lipoproteinosis. | Electron microscopy in an infant of 4 months with pulmonary alveolar lipoproteinosis showed filling of the alveoli with osmiophilic lamellar bodies. Similar structures were present in the cytoplasm of type I alveolar epithelial cells and to a lesser extent in the capillary endothelium and interstitium. These changes re... | 202,067 | [
-0.2042375,
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0.2194446,
0.1000314,
0.1144022,
0.3893552,
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[Adenylate kinase and creatine kinase activity of rabbit blood serum following application of a tourniquet to the thigh]. | A colorimetric method is described for estimation of the adenilate kinase activity in blood serum; the method is based on coupling of adenilate- and creatine kinase reactions and on estimation of the amount of creatine formed. Adenilate kinase activity in blood serum, estimated by the method, was shown to increase 4-fo... | 202,085 | [
0.009058872,
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0.3052512,
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0.3560443,
0.3985647,
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... |
[Pyridoxal kinase activity in human tumor tissues]. | Activity of pyridoxal kinase (per 1 g of tissue or per 1 mg of protein) varied in the range from 7 to 39 un or from 0.079 to 0.4 un in human malignant neoplasm tissues (adenocarcinoma of various localization, squamatous cell carcinoma of lungs, skin melanoma). The direction of alterations in the pyridoxal kinase activi... | 202,094 | [
-0.124252,
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0.4125411,
0.4524316,
0.1132103,
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0.... |
[Development of action potentials spreading antidromally from an acute epileptogenic focus through the corpus callosum]. | The activity of callosal neurones located in the sensorimotor cortical area was studied in unanaesthetized rabbits. An epileptogenic focus was produced by application of penicillin or strychnine in the homotopic region of the contralateral hemisphere. During hyperpolarization of the membrane, corresponding to the appea... | 202,107 | [
0.09526528,
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0.02103415,
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0.01070462,
0.04463344,
... |
Studies on NAD+ permeability in intact mitochondria from rabbit reticulocytes. | Functionally intact mitochondria from rabbit reticulocytes are characterized by a low NAD+ level after the preparation (0.29 nmoles NAD+ + NADH/mg protein). They are apparently impermeable for NADH and exhibit a slow net uptake of NAD+. From the increase of O2-uptake in state 3 and the increase of NADH concentration in... | 202,125 | [
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0.1709672,
0.1193461,
0.09378445,
0.2432238,
0.... |
Computed tomography in the evaluation of sarcomatous tumors of the thigh. | CT examination of a soft tissue mass in the lower extremity adds substantially to a more precise preoperative histologic diagnosis and anatomic localization of the lesion. An appreciation of the normal cross-sectional anatomy of this region is essential for adequate evaluation of the information provided by the CT scan... | 202,155 | [
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0.1011477,
0.2089942,
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... |
Isolation of enzymatically homogeneous populations of human lymphocytes, monocytes, and granulocytes by zonal centrifugation. | Human monocytes, lymphocytes, granulocytes, red cells, and platelets were completely separated from each other by zonal centrifugation on linear sucrose density gradient. The monocytes contained only one tenth the amount of myeloperoxidase, one half the amount of lysozyme, one half the amount of acid ,hosphatase, and o... | 202,168 | [
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0.4111231,
0.09228939,
0.01832272,
-0.0309... |
Prevalence of ovine progressive pneumonia in a sampling of cull sheep from western and midwestern United States. | Ovine progressive pneumonia was found to be prevalent in many major sheep-producing areas in the United States. The incidence was determined in a sampling of cull sheep (5 to 10 years of age) at slaughter. Diagnostic criteria were based on finding viral-specific immunoglobulins, virus, or lesions. Each method indicated... | 202,181 | [
-0.1714771,
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0.1267246,
0.597054,
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0.08544283,
0.2979841,
-0.279877... |
Development of poliovirus having increased resistance to chlorine inactivation. | A laboratory strain of poliovirus (LSc) became progressively more resistant to chlorine inactivation during a series of repeated sublethal exposures to the halogen. | 202,195 | [
-0.1799765,
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... |
Dietary and serum lipids in the multifactorial etiology of atherosclerosis. | The incidence of severe atherosclerosis is ascribable to a multiplicity of risk factors, cardinal among which is the serum cholesterol concentration. The dietary fat content, the serum cholesterol level, and the incidence of atherosclerosis are clearly correlated in different countries and in population cohorts. Within... | 202,219 | [
-0.003599479,
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0.00341793,
0.2373549,
0.11266,
0.1916486,
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... |
Studies on glycopeptides of Herpes simplex virus infected cells. | Trypsinates from HSV infected cells, radioactively labeled with glucosamine and galactose were further digested by pronase. The digests were subjected to gel filtration, and it was shown that some of the eluted material consisted of saccharides, highly devoid of residual peptide. This material eluted between linear dex... | 202,227 | [
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0.06099576,
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Alterations in regulation of insulin biosynthesis in pregnancy and starvation studied in isolated rat islets of langerhans. | 1. Insulin biosynthesis in isolated rat islets of Langerhans was determined by the incorporation of [(3)H]leucine into newly synthesized islet proteins. Anti-insulin serum covalently coupled to a solid phase (CNBr-activated Sepharose 4B) was used to separate the immunoreactive proinsulin and insulin from other islet pr... | 202,248 | [
0.3240345,
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0.2005347,
0.3494383,
0.2258008,
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... |
Mitochondrial respiratory chain of Tetrahymena pyriformis: the properties of submitochondrial particles and the soluble b and c type pigments. | Submitochondrial particles isolated from Tetrahymena pyriformis contain essentially the same redox carriers as those present in parental mitochondria: at pH 7.2 and 22 degree C there are two b-type pigments with half-reduction potentials of --0.04 and --0.17 V, a c-type cytochrome with a half reduction potential of 0.2... | 202,305 | [
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0.2923554,
0.1788709,
0.3932097,
... |
The operation of the malate-aspartate shuttle in the reoxidation of glycolytic NADH in slices of fetal rat liver. | Lactate production by liver slices from fetal rats (17th--18th day of gestation) is enhanced about two fold by aminooxyacetate, an inhibitor of aspartate transaminase (EC 2.6.1.1). Such an effect is consistent with an increase of the cytosolic NAD-redox state owing to the parallel fall in the pyruvate level, whereas th... | 202,312 | [
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0.252202,
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0.0892624,
0.1413206,
0.3816582,
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0.... |
Studies on the orientations of the mitochondrial redox carriers. II. Orientation of the mitochondrial chromophores with respect to the plane of the membrane in hydrated, oriented mitochondrial multilayers. | Orientations of the active site chromophores of the mitochondrial redox carriers have been investigated in hydrated, oriented multilayers of mitochondrial membranes using optical and EPR spectroscopy. The hemes of cytochrome c oxidase, cytochrome c1, and cytochromes b were found to be oriented in a similar manner, with... | 202,316 | [
-0.3151137,
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0.05138396,
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0.3100392,
0.1969624,
0.2014721,
... |
Studies on the regulatory properties of chloroplast fructose-1,6-bisphosphatase. | The regulatory properties of chloroplast fructose-1,6-bisphosphatase (D-fructose-1,6-bisphosphate 1-phosphohydrolase, (EC 3.1.3.11) were examined with a homogeneous enzyme preparation isolated from spinach leaves. The activation of the enzyme, that was earlier shown to occur via reduced thioredoxin, was found to be acc... | 202,319 | [
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0.1887549,
0.2345747,
0.03317553,
0.413885,
0.5393979,
-0.3310784,... |
A psychophysiological investigation of the short-term effects of clozapine upon sleep parameters of normal young adults. | A nine consecutive night, double-blind design was used to assess the effects of a psychotropic agent (clozapine) upon sleep parameters as well as measures of mood and performance in a group of seven normal, young adults. Placebo was administered to a control group of seven subjects. EEGs and EOGs were monitored through... | 202,346 | [
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0.3318782,
-0.172559... |
[Electrophoretic study of the nuclear membrane ribonucleases of rat liver and hepatoma-27 cells]. | Purified cell nuclei from the rat liver and hepatoma-27 cells were used to prepare nuclear membranes from which the enzyme-containing extracts of acid-soluble proteins were prepared. The protein extracts were subjected to disc-electrophoresis in 15% polyacrylamide gel using modified Reisfeld's system. It was found that... | 202,350 | [
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0.1777234,
0.02663824,
0.3822946,
0.005581093,
-0.3369586... |
[Effect of cholesterol on membrane Na,K-activated adenosine triphosphatase]. | The membrane preparations of rat brain Na,K-ATP-ase with different amount of cholesterol were obtained by using high-cholesterol diet or cholesterol-oxidase treatment. The cholesterol/protein ratio varied from 0.034 to 0.252 (normal--0.152). An increase of this ratio removes the curvature on the Arrhanius' plots for Na... | 202,351 | [
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0.3218966,
0.4848031,
0.1805,
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0... |
[Activity of glucose-6-phosphate metabolism enzymes in the livers of rats with experimental valekson poisoning]. | The activity of hexokinase, glucose-6-phosphatase and glucose-6-phosphoric dehydrogenase was studied in the liver of rats after one hour, one and five days after a single oral administration of organic phosphorus insecticide valekson. It was determined that administration of the preparation led to an increase of activi... | 202,353 | [
-0.2159325,
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0.3289173,
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Implication of developmentally regulated Concanavalin A binding proteins of Dictyostelium in cell adhesion and cyclic AMP regulation. | Contact sites A and cyclic AMP phosphodiesterase are Concanavalin A binding membrane proteins. Both are characteristic for the aggregation phase of Dictyostelium discoideum. Extracellular cyclic AMP phosphodiesterase and an inhibitor of this enzyme can be recovered from the extracellular medium by binding to Concanaval... | 202,402 | [
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0.1027089,
0.6491439,
0.1830828,
-0.1278356,... |
[Histochemical and quantitative methods in the biopsy examination of skeletal muscles]. | A complex bioptic examination of skeletal muscles as carried out in 280 excised samples has been subjected to a critical analysis. The examination suggested consists of histological and histochemical processing of native cryostat sections. Besides conventional staining methods the techniques recommended include the rea... | 202,410 | [
0.07413056,
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0.3539683,
0.1379886,
-... |
Poliomyelitis: epidemiology and prophylaxis. 4. Serological and virological surveys conducted after a mass vaccination campaign for the control of a threatening poliomyelitis epidemic. | In 1973, a type 1 poliomyelitis epidemic in Kenya was curtailed at an early stage by two mass distributions of trivalent oral vaccine. It was considered useful to know the immunity status of the child population that had resulted from the vaccine distributions and that had presumably contributed to its control. We also... | 202,417 | [
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0.4818276,
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0... |
Poliomyelitis: epidemiology and prophylaxis. 5. Results of a two- and three-dose vaccination experiment. | In tropical countries, seroconversion rates following oral poliomyelitis vaccination are frequently unsatisfactory. In an area of the Machakos district in Kenya, 4000 children under 5 years of age have been registered and are visited fortnightly by trained field staff as part of a comprehensive, population-based, longi... | 202,418 | [
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0.008365314,
0.3775864,
0.3994423,
0.4479546,
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0... |
A novel alkaline phosphatase, a minor component of normal liver phosphatases. | A novel alkaline phosphatase differing from the so-called liver-specific isoenzyme was found in four out of twenty-four normal adult livers. Although the mobility of this enzyme was the same as that of so-called liver-specific alkaline phosphatase on the polyacrylamide gel electrophoretogram, its mobility was not alter... | 202,420 | [
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0.04356446,
0.1827106,
0.07318032,
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-0.4224982,
... |
Effect of isometric exercise on catecholamines in the coronary circulation. | Arterial and coronary sinus blood levels of catecholamines, adenosine 3', 5'-cyclic monophosphate (c-AMP) and lactate were measured during isometric exercise in fourteen patients. In no patient did lactate production occur. Mean resting total catecholamine levels both arterial (0.53 +/- 0.07 ng/ml; 2.94 +/- 0.38 nmol/l... | 202,452 | [
-0.4364107,
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0.007011892,
0.0730412,
0.299778,
0.006630995,
0.02... |
[Effect of anticholinesterase agents on the protein and RNA content in the cells of the supraoptic nucleus during sleep and its disorder]. | In rats, administration of anticholinesterase drugs (both the penetrating blood-brain barrier armin and the nonpenetrating preparation Gd-42) prevented the decrease of protein content in the neurons and glia of the supraoptic nucleus, as well as of RNA content in the neurons which usually occurred in intact animals aft... | 202,513 | [
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0.1519637,
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0.2865036,
0.1413984,
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0.3289524,
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0.4088194,
-0.0641086,
-0.2776292,
-0.04357351,
... |
Cell-mediated cytotoxicity: comparison of primary and secondary immune reactions after parainfluenza type 1 virus inoculation. | H-2 antigen compatibility of effector spleen cells and target cells was necessary for cell-mediated cytotoxicity (CMC) after both 1 and 2 intraperitoneal inoculation of 6/94 virus into mice. T cells were responsible for both primary and secondary CMS reactions. Neither reaction was influenced by the presence of virus-s... | 202,521 | [
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0.483814,
0.3740819,
0.04277137,
-0.0788616,
... |
Hematological alterations in tumor-bearing rats, with reference to pathogenesis of chronic type of disseminated intravascular coagulation syndrome. | Hematological studied were carried out serially in the rats transplanted subcutaneously with Yoshida ascites hepatoma AH-109A. Significant changes were observed in fibrinogen level, fibrinogen degradation products, recalcification time, platelet count, and fragmentation of red blood cells. Formation of thrombi was reve... | 202,534 | [
0.07756894,
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0.3124637,
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0.1913892,
0.1892687,
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0.5302269,
0.07515153,
0.1465885,
0.3098756,
-0.07247011,
... |
Transformation of human cells by temperature-sensitive mutants of simian virus-40. | Conditions necessary for the establishment and maintenance of transformation of human cells by wild type and temperature-sensitive mutants of SV40 were examined. For both early and late mutants, the frequency of transformation was found to be up to 5-fold higher, and virus yield 100-fold lower, at 39 degrees than at 33... | 202,569 | [
-0.02896975,
-0.2308892,
-0.424696,
0.1721879,
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0.2587743,
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-0.1416271,
0.3173504,
0.1205594,
0.3322025,
-0.1482072,
... |
Energy transduction and adenine nucleotides in mitochondria from rat liver after hypoxic perfusion. | The characteristics of mitochondria isolated from perfused livers of rats under hypoxic or oxic conditions were studied. The electron transfer activity was about 60% of normal after hypoxic perfusion for 3 h, but respiratory control was abolished almost completely. These parameters recovered considerably on subsequent ... | 202,589 | [
-0.2415771,
0.03024131,
-0.00414959,
0.4103208,
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0.1600289,
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0.04156939,
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0.2062717,
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0.04431316,
-0.5480978,
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-0.09152125,
-0.009787361,
0.2243913,
0.011... |
Increased membrane transport of 2-deoxyglucose and 3-O-methylglucose is an early event in the transformation of chick embryo fibroblasts by Rous sarcoma virus. | Transformation of chicken embryo fibroblasts with Rous sarcoma virus results in cells with an enhanced rate of hexose uptake. We have examined transport of the glucose analogs 2-deoxyglucose and 3-O-methylglucose in cells infected with a temperature sensitive variant of the virus. In cells shifted from restrictive to p... | 202,604 | [
-0.2663703,
-0.2638028,
-0.4972512,
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0.0660506,
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0.3168643,
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0.07268936,
0.3403963,
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... |
Interaction of polymorphonuclear neutrophils with Escherichia coli. Effect of enterotoxin on phagocytosis, killing, chemotaxis, and cyclic AMP. | Enterotoxigenic Escherichia coli are associated with noninflammatory diarrhea and stimulate adenylate cyclase activity of mammalian cells, thereby increasing intracellular cyclic adenosine 3',5'-monophosphate (cyclic AMP). Increased concentrations of cyclic AMP in polymorphonuclear neutrophils (PMN) inhibit phagocytosi... | 202,610 | [
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0.01293947,
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0.2664135,
0.3457936,
0.2472808,
0.04309706,
... |
Dose-response relationships in a microneutralization test for foot-and-mouth disease viruses. | Two-dimensional quantal microneutralization tests on foot-and-mouth disease viruses, in which neutralizing antibody activity was titrated against a serial range of virus doses, demonstrated a variety of dose-response curves some of which were rectilinear, others clearly curvilinear. Moreover, in the case of the non-lin... | 202,650 | [
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0.3370675,
0.1427817,
-0.0216024,
0.0986070... |
Characterization of a fetal calf serum-derived molecule reactive with human natural antibodies: its occurrence in tissue culture-grown type C RNA viruses. | By means of a sensitive radioimmunoprecipitation (RIP) assay, simian sarcoma virus-simian sarcoma-associated virus (SSV-SSAV), purified from culture fluids of infected normal rat kidney (NRK) cells, was shown to acquire a surface antigen from serum used in the tissue culture medium. This antigen, which was acquired whe... | 202,656 | [
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0.3503181,
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-0.1313543,
-0.0002227064,
0.1882341,
-0.01018103,
-0.1375989,
-0.4988... |
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