title stringlengths 0 901 | abstract stringlengths 3 9.89k | PMID int64 22 25.3M | embedding listlengths 768 768 |
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Fundamental aspects of electron transfer: experimental verification of vibronically coupled electron tunneling. | A detailed investigation of the applicability of the vibronically coupled electron tunneling theory in biomolecules can be made by a quantitative study of a weak charge-transfer optical absorption band that has been predicted by this theory. The measurement of the position, width, and molar extinction coefficient of th... | 198,806 | [
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Amyloid protein SAA is associated with high density lipoprotein from human serum. | Human serums contain a protein antigenically related to protein AA, the principal protein of a major class of amyloid substance. The serum antigen, SAA, occurs mainly in a high molecular weight form, 1 to 2 X 10(5). This work shows that the bulk of the SAA sediments at density 1.12 g/cm3 and floats at density 1.21 g/cm... | 198,813 | [
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Specific receptors for des-Asp1-angiotensin II (("angiotensin III") in rat adrenals. | The specific binding of angiotensin II and des-Asp1-angiotensin II ("angiotensin III") III") to rat adrenals was studied with the use of the tritiated peptides. The binding sites having maximal affinity for angiotensin II were characterized by an equilibrium dissociation constant of 3.3 to 5.2 X 10(-9) M. Angiotensin I... | 198,814 | [
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Combination chemotherapy and radiotherapy in small-cell carcinoma of the lung. | A combination of chemotherapy (Cytoxan, vincristine, and CCNU) and radiation therapy was used to treat 37 patients with small-cell carcinoma of the lung. There was 49% complete remission and an overall 76% objective response with an overall median survival of 12.5 months and 17 months for those showing a complete respo... | 198,846 | [
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[Syndrome of inappropriate secretion of vasopressin. Apropos of 3 cases]. | 3 cases of inappropriate vasopressin secretion during one case of anaplastic carcinoma of the lung, one case of carcinoma of the prostate with bony metastases and one case of acute intermittent porphyria are presented. The plasma levels of vasopressin, measured by radioimmunoassay were high. Treatment with demeclocycli... | 198,887 | [
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Inhibition by somatostatin of mouse thyroid activity following stimulation by thyrotrophin, isoprenaline and dibutyryl cyclic-AMP. | The recent discovery of somatostatin-containing cells within the thyroid gland infers that somatostatin may influence thyroid activity. This possibility was investigated by measurements of radio-iodine release in mice pre-treated with 125I and T4. The animals were treated with TSH, isoprenaline or dibutyryl-cyclic AMP ... | 199,013 | [
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Biochemical studies on the leukocytes in Chediak-Higashi syndrome. | Blood leukocytes from a patient with Chediak-Higashi syndrome (CHS) were compared with normal cells for their capacity of extruding (exocytosis) the lysosomal enzyme myeloperoxidase during phagocytosis or after a treatment with the ionophore A23187 and Ca2+. A decreased rate and extent of exocytosis in phagocytizing CH... | 199,018 | [
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The adrenocortical response to angiotensin II infusion in anephric and non-nephrectomized patients on regular hemodialysis. | In the present study 8 anephric and 4 non-nephrectomized patients were stimulated with angiotensin II (A-II). In 5 of the anephric patients, an increased plasma aldosterone concentration (PAC) in response to ACTH stimulation had previously been demonstrated. After A-II stimulation, all 8 anephric patients responded wit... | 199,049 | [
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Cytomegalovirus retinitis secondary to chronic viremia in phagocytic leukocytes. | We studied the relationship between the duration and intensity of cytomegalovirus viremia, cytomegalovirus complement fixing antibody, and cytomegalovirus retinitis in 61 renal transplant recipients. Five (8%) patients had chronic viremia which lasted more than six months. Two of the five developed typical cytomegalovi... | 199,065 | [
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Hypersensitivity to adrenergic stimulation after propranolol withdrawal in normal subjects. | The cardiac response to isoproterenol after propranolol withdrawal was studied in six normal persons. Serial isoproterenol infusions were done before and after oral propranolol administration, 160 mg daily for 2 days. Changes in electromechanical systole corrected for heart rate (QS2I) and pulse pressure were used to a... | 199,099 | [
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Induction of polymyxin resistance in Pseudomonas fluorescens by phosphate limitation. | Shift of Pseudomonas fluorescens NCMB 129 from a a phosphate rich into a phosphate limited medium results in a reduction of the membrane phospholipids phosphatidylethanolamine, phosphatidylglycerol and cardiolipin. Concomitantly a positively charged ornithine amide lipid is synthesized. The gradual increase of this lip... | 199,125 | [
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Evidence against involvement of endorphins in sexual arousal and orgasm in man. | In a double-blind study, intravenous injection of naloxone, at a dose sufficient to saturate the opiate (endorphin) receptors, had no effect on sexual arousal, penile erection, ejaculation, or orgasm in a human subject. Apparently, endorphins are not involved in these phenomena. | 199,128 | [
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Adenomyoma: a precursor of extrauterine Müllerian adenosarcoma? | One patient had an extrauterine pelvic Müllerian adenosarcoma that recurred on multiple occasions and was originally diagnosed as a benign lesion. Caution is needed in the initial interpretatrion of such lesions as "adenofibromas." We have compared this lesion with a benign adenomyoma of the uterus from a second patien... | 199,134 | [
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The effect of macrophage poisoning by silica on experimental pulmonary contusion and its benzo-pyrone treatment. | The effect of poisoning the macrophages with silica on the fine structure of pulmonary contusion was studied in rats. It was found that this causes an increase in the concentration of protein in the interstitial tissue and in the air spaces. It also causes a consequent increase in the amount of interstitial oedema. Whi... | 199,228 | [
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Pregnancy complicated by insulinoma. Case report. | An insulinoma was excised during pregnancy. The tumor was located by radiography and severe hypoglycaemia made it necessary to administer diazoxide to the mother. The out come in the pregnancy was satisfactory. The rationale and risks of giving diazoxide in pregnancy are discussed. | 199,230 | [
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[Activities of some yeast flavogenic enzymes in situ]. | Effects of digitonin, dimethylsulfoxide and protamine sulfate on yeast Pichia guilliermondii were studied in order to produce cells with increased permeability and possessing the GTP-cyclohydrolase, riboflavinsynthetase and riboflavinkinase activities. The digitonin-treated cells exhibited a higher cyclohydrolase activ... | 199,288 | [
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Axonal regeneration in the rat sciatic nerve: effect of a conditioning lesion and of dbcAMP. | After the sciatic nerve had been crushed at the level of the mid-thigh, the rate of outgrowth of the regenerating axons was measured by using the pinch test to locate the leading sensory axons. This standard crush lesion ("testing" lesion) elicited axonal outgrowth at a rate of 4.3 +/- 0.1 mm/day, with an initial delay... | 199,316 | [
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A family with syndactyly type II (synpolydactyly). | Syndactyly Type II is reported in eight members of a family in four generations. Affected individuals show two distinctive patterns of variation in the expression of the gene. Distortion of dermatoglyphic patterns is associated with the severe but not the mild manifestation of the malformation. The diagnostic significa... | 199,388 | [
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Plasma concentration of pyridostigmine and effects in myastenia gravis. | The relation between the plasma concentration of pyridostigmine and its effects was studied in 5 patients with myasthenia gravis. In 4 patients with typical electromyographic decrement in the adductor pollicis, there was a positive correlation between the concentration of pyridostigmine in plasma and the effect on neu... | 199,393 | [
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The passage of apoproteins from plasma lipoproteins into the lipoproteins of peripheral lymph in man. | 1. The transport of apoprotein B from the lipoprotein of plasma into the lipoproteins of lymph draining the foot has been studied in four men with type III hyperlipoproteinaemia. 2. Three subjects were given autologous 125I-labelled very-low-density lipoprotein (VLDL) and 131I-labelled low-density lipoprotein (LDL) by ... | 199,396 | [
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Modification of glycoprotein residues as Ca2+ receptor sites after chronic ethanol exposure. | Previous studies have demonstrated that chronic low-dose administration of ethanol in the drinking fluid of rats produces an increase in content of calcium on synaptic membranes. In the present study, ethanol was studied in vitro and in vivo for its effects on Ca2+ binding to a high affinity receptor site on synaptic m... | 199,405 | [
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DNA unwinding enzyme II of Escherichia coli. 2. Characterization of the DNA unwinding activity. | The DNA-stimulated 75000-Mr ATPase described in the preceding paper is shown to be a further catalytic DNA unwinding principle (DNA unwinding enzyme II) made in Escherichia coli cells (the first being the 180000-Mr ATPase of the cells: DNA unwinding enzyme I). Unwinding depends strictly, on the supply of ATP. It occurs... | 199,441 | [
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[Acceleration of the initial stages of thrombin clearance in the bloodstream of rats during stress]. | In a stress due to 30-min immobilization, the initial stages of the thrombin clearance in the blood flow of rats are considerably accelerated. Thus, in 5 min after i.v. administration of thrombin I131, The blood relative radioactivity in experimental rats decreases by about 40% while in the control animals--by 20%. The... | 199,473 | [
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Clinical recovery owing to target parietal cell failure in a patient with Zollinger-Ellison syndrome. | A patient is presented with Zollinger-Ellison syndrome, in whom spontaneous disappearance of gastric hypersecretion and peptic ulcer disease occurred subsequent to an intercurrent illness causing acute nonspecific inflammation of the gastric mucosal lining. The dramatic clinical improvement after subsiding of the inter... | 199,524 | [
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[Adjuvant activity of gram-negative bacteria and their structural components (author's transl)]. | Regarding the adjuvant activity of gram-negative bacteria we have to distinguish at least 4 different potencies, i.e., 1) increase in the production of circulating antibodies during the primary and secondary immune responses; 2) induction of susceptibility to systemic anaphylaxis; 3) prompt production of experimental "... | 199,540 | [
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Biochemical analysis of genetic recombination in eukaryotes. | Recent studies concerning molecular mechanisms of genetic recombination in eukaryotes are reviewed. Since many of these studies have focused on the testable predictions arising from the hybrid DNA theory of genetic recombination, this theory is summarised. Experiments to determine the time of meiotic crossing-over and ... | 199,560 | [
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Isolated, ventilated, perfused newborn rabbit lung preparation and its assessment. | To achieve an isolated, ventilated, perfused newborn rabbit lung preparation, newborn rabbits are anesthetized and ventilated. The pulmonary vasculature is perfused with a Krebs-Ringer bicarbonate solution containing glucose and plasma expanders, and the lungs are isolated in a 37 degrees C chamber at 100% humidity. Th... | 199,567 | [
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Nereis cuticle collagen. Isolation and properties of a large fragment resistant to proteolysis by bacterial collagenase. | Native cuticle collagen, obtained from Nereis virens, was incubated with purified bacterial collagenase (EC 3.4.4.19). The kinetics of proteolysis were monitored by viscometry, in parallel with similar digestions of calf skin collagen. Comparison of the kinetics of digestion of the two collagens, at similar enzyme to s... | 199,599 | [
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0.3520712,
0.147093,
-0.1511814,
-0.06913028,
-0.2171959,
-0.4459864,
-0.5016459,
0.0371942,
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0.1589032,
-0.01996461,
0.09237688,
0.6432901,
0.339088,
-0.3668044,
0.... |
High-pressure liquid chromatography of amino acids and dipeptides on a tripeptide bonded stationary phase. | A bonded tripeptide (L-valyl-L-phenylalanyl-L-valine) phase has been used as a stationary phase in liquid chromatography. Unique retention orders and retention variations are shown for phenylthiohydantoin (PTH) derivatives of amino acids and isomeric dipeptides using acidic and basic mobile phases. It is shown that the... | 199,609 | [
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0... |
The calcium and vitamin D status in an elderly female population and their response to administered supplemental vitamin D3. | Recent reports have implicated the importance of impaired calcium absorption, inadequate dietary vitamin D, and low serum vitamin D levels in the genesis of metabolic bone diseases in the elderly. This study evaluated the dietary intakes of calcium and Vitamin D, calcium absorption, and serum 25 hydroxycholecalciferol ... | 199,641 | [
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... |
Cation and anion sequences in dark-adapted Balanus photoreceptor. | Anion and cation permeabilities in dark-adapted Balanus photoreceptors were determined by comparing changes in the membrane potential in response to replacement of the dominant anion (Cl-) or cation (Na+) by test anions or cations in the superfusing solution. The anion permeability sequence obtained was PI greater than... | 199,688 | [
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0.07278445,... |
Some properties of recombinants between type 1 and type 2 herpes simplex viruses. | Four intertypic recombinants of herpes simplex virus have been shown to possess genetic information for functions characteristic of each of the two parental types. The functions were identified by (a) polyacrylamide gel electrophoresis of purified virus particles and of polypeptides synthesized in cells infected with t... | 199,695 | [
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Biological properties of avian coronavirus RNA. | RNA with a sedimentation coefficient of 64S was isolated from infectious bronchitis virus, an avian coronavirus. The SNA contained a polyadenylic acid tract and was found to be infectious. | 199,697 | [
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Paget's disease of the scrotum presenting as an inguinal lymph node. | Extramammary Paget's disease is a rare malignant entity. A case with a unique clinical presentation is described and emphasis is placed on the need for early biopsy of skin lesions in the genital area. | 199,748 | [
-0.1334937,
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Depressive effect of epinephrine mediated via adrenergic beta-receptor in isolated rat colon and duodenum. | Differences in sensitivity to catecholamines between colon and duodenum were examined in tissues from the rat, monitoring the depressive effect of catecholamines on contractile response to acetylcholine (ACh). The sensitivity of colonic tissue to ACh was higher than that of duodenal. Epinephrine (Ep, 10(-7) g/ml) depre... | 199,772 | [
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[Investigations of the urinary cAMP-excretion in pseudohypoparathyroidism (author's transl)]. | Pseudohypoparathyroidism (PHP) is a hereditary disorder with typical dysmorphic signs and clinical and laboratory symptoms of hypoparathyroidism which is resistant however to parathyroid extract. ALBRIGHT and coworkers supposed that this resistance was caused by an inability of the renal tubules to respond to parathyro... | 199,875 | [
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0.2436486,
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0.424154,
0.4619585,
0.1528851,
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0.14... |
The action of collagenase on K-type Bence-Jones proteins. | The proteolytic action of a bacterial collagenase on two Bence-Jones k chains has been studied and the localization of the cleavage sites accomplished. The implications of this enzymatic attack are discussed. | 199,879 | [
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A modified method for the preparation of agarose. | A simple procedure for the preparation of agarose suitable for electrophoresis is developed in which anionic polysaccharides are removed by extracting the agar gel-granules with phosphate buffer (0.03 M, pH 6.8) containing urea (4 M), followed by electrophoresis in the same buffer system. Further, alkali treatment in t... | 199,902 | [
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0.04140648,
0.06518701,
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0.3102937,
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[Hereditary myeloperoxidase deficiency. Clinical, biological and genetic study]. | A case is reported of hereditary myeloperoxidase deficiency in a diabetic patient suffering from a Candida albicans hepatic abscess. Myeloperoxidase (MPO) is completely absent from the neutrophils and monocytes, although it is present in the eosinophils. Functional granulocyte studies have revealed normalchemotactic an... | 199,939 | [
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0.2784407,
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0.1306187,
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0.1533204,
0.15917... |
Somatotrophic, thyrotrophic and adrenocorticotrophic functions of the anterior pituitary in obesity. | The basal plasma level of GH, TSH and ACTH and the reserve capacities of the adenohypophysis in the secretion of these hormones was investigated radioimmunologically in 80 patients with excessive weight (from 15.3% to 180.0%) and a group of healthy subjects. It is shown that obesity is accompanied by diverse changes of... | 199,933 | [
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0.02266608,
0.2252423,
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... |
Pituitary nuclear 3,5,3'-triiodothyronine and thyrotropin secretion: an explanation for the effect of thyroxine. | An excellent correlation was observed between nuclear triiodothyronine (T3) and the ensuing suppression of thyrotropin (TSH) after a single intravenous injection of T3 to thyroidectomized (hypothyroid) rats. At 1 and 2 hours after injection of thyroxine (T4), in amounts equally potent to the administered T3 in terms of... | 199,941 | [
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0.08018539,
0.3916399,
0.03075617,
0... |
[Pz peptidase activity in serum (author's transl)]. | Synthetic PZ peptide, synthesized by Wünsch and Heidrich, was used as substrate to determine PZ peptidase activities in the sera of man, rabbit, guinea pig and mouse. The PZ peptidase from rabbit serum was purified 200 fold and characterized. The enzyme has an isoelectric point of 5.0 and pH optima at pH 7.2 and pH 7.9... | 200,019 | [
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0.2351514,
0.1585368,
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0.0... |
[Gestagen therapy in bladderneck adenoma. III. Clinicochemical findings and course controls in patients with bladderneck adenomas under gestagen therapy]. | It is reported on clinico-chemical examinations in 30 carriers of adenomas, who underwent a gestagen therapy lasting 3 months. The treatment was performed in group I in 15 patients with progesterone depot and in group II with depostate. After the end of the treatment in group I an increase of the content of the sodium ... | 200,033 | [
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0.1136052,
0.4101393,
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0.... |
[Disintegration of enzymatically pretreated cartilage after subcutaneous implantation]. | The influence of previous digestion of cartilage proteoglycans and collagen on cartilage resorption in implants was studied. After implantation for 1, 2, 3, and 4 weeks the morphology of the implants was studied by light microscopy. It was found that enzymatic treatment of cartilage with hyaluronidase, collagenase as ... | 200,032 | [
0.2011709,
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0.4694697,
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0... |
Longitudinal study of the behaviour of certain hormonal parameters in women undergoing treatment with cyproterone acetate. | A study has been made of the behaviour of certain hormonal parameters (LH, FSH, PRL, HGH, ACTH, cortisol and testosterone) in five women aged from 17 to 28 years, during two successive menstrual cycles, the first under basal conditions and the second while under treatment with cyproterone acetate (CPA) 100 mg/day), giv... | 200,047 | [
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0.0... |
[Current therapy of juvenile nasopharyngeal angiofibroma]. | The nasopharyngeal angiofibrom continues sometimes to challenge the otolaryngologists because of the difficult radical surgery owing to the deep anchorage of the tumor in the base of the skull. In these cases, when possible, the embolization followed by surgery or the radiotherapy are the two better treatments. Without... | 200,056 | [
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0.3678651,
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Suppression of the excitatory adrenergic neurotransmission; a possible role of cholinergic nerves in the retractor penis muscle. | The excitatory adrenergic response to transmural nerve stimulation of the isolated retractor penis (rp) of dog, cat, horse, boar, elk, bull, ram and goat, as well as the evoked release of 3H from dog rp preloaded with 3H-noradrenaline were studied. In untreated preparations a low concentration of scopolamine could mark... | 200,067 | [
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LDH isoenzyme electrophoretic pattern differences between colloid and other adenocarcinomas of the colon. | LDH isoenzyme electrophoretic patterns have been studied in 27 adenocarcinomas of the colon. The different content of M monomer in poorly differentiated tumors is statistically significant (P less than 0.001) when compared to well-differentiated tumors of the colon. Such a difference has not been found for two Broders ... | 200,137 | [
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0.007911499,
0... |
Differences in growth of transplants of liver, liver hyperplastic nodules, and hepatocellular carcinomas in the mammary fat pad. | Transplantation of fragments of normal rat liver autologously and isologously into the inguinal mammary fat pad permitted survival for up to 75% of grafts for 38 weeks, the longest interval studied. Similarly transplanted hepatocarcinomas grew rapidly and progressively in this site. Neither autologous or isologous tran... | 200,143 | [
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0.1593747,
0.1293238,
0.1790841,
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... |
The prognosis of lung cancer originating as a round lesion. Data from the Philadelphia pulmonary neoplasm research project. | A population of 6,027 men 45 or more years of age was screened every 6 months for 10 years with chest photofluorograms and questionnaires regarding symptoms. Although volunteers, they were similar to older men in the general population with respect to age, race, and smoking habits. Of 121 men who developed lung cancer ... | 200,157 | [
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... |
Type III hyperlipoproteinemia: diagnosis in whole plasma by apolipoprotein-E immunoassay. | Because the cholesterol-rich very low density (VLD) lipoproteins of subjects with type III hyperlipoproteinemia are distinctively enriched in apolipoprotein E, a radial immunodiffusion assay for apolipoprotein E in whole plasma was developed. Its diagnostic usefulness was tested in randomly selected (n = 174) and hyper... | 200,160 | [
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0.08485551,
0.1158978,
0.4442025,
0.009233242,
... |
Influence of cyclic nucleotides and a phosphodiesterase inhibitor on in vitro human blood neutrophil chemotaxis. | Cyclic AMP and dibutyryl cyclic AMP as well as several 8-substituted analogs of cyclic AMP inhibited in vitro human blood neutrophil chemotaxis. Cyclic GMP enhanced chemotaxis. 8-substitution on the cyclic GMP nucleus markedly dampened the cyclic GMP effect. SQ 20,009, a potent phosphodiesterase inhibitor when tested a... | 200,191 | [
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0.3722368,
0.1266479,
0.07205547,
0.06336433,... |
Acute peripheral facial palsy. Part of a cranial polyneuropathy? | In 14 of 16 consecutive patients with acute peripheral facial palsy, one or more (up to four) other nerves were involved. The nerves affected in addition to the facial nerve were as follows: trigeminal (ten patients), vestibular (eight), cochlear (six), vagus (one), and upper cervical (five). Virus was not isolated fro... | 200,210 | [
0.04980496,
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0.107428,
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0.1638175,
0.1665243,
-0.2288929,
-0.1499039,... |
Preweaning mortality in the pig. Pathological findings in piglets dying between birth and weaning. | During a survey of preweaning mortality 538 piglets which died between birth and weaning were autopsied. The results of laboratory examinations permitted a division of the findings into a number of syndromes which were considered to be associated with the immediate cause of death. The non-infectious conditions such as ... | 200,212 | [
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0.1406001,
0.152589,
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0.1814114,
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-0.1... |
Aldolase-like imine formation in the mechanism of action of phosphonoacetaldehyde hydrolase. | Phosphonoacetaldehyde hydrolase (EC 3.11.1.1), the bacterial enzyme that catalyses the reaction HCO-CH2-PO(OH)2+H2O leads to HCO-CH3+Pi, is inactivated by borohydride if either phosphonoacetaldehyde or acetaldehyde is present. This supports the suggestion that the substrate forms an imine with an amino group of the enz... | 200,222 | [
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0.05560632,
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0.2170416,
0.2896048,
0.1634223,
0.2202426,
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0.1... |
[Receptor occupation and pharmacological activity as demonstrated on opiates (author's transl)]. | The availability of highly radioactively labelled opiates with high receptor affinity has made it possible to identify and characterize opiate receptors in vitro as well as in vivo. These investigations revealed that the affinity of the compounds to the receptor decides about the pharmacological potency of the compound... | 200,250 | [
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Angiotensin I converting enzyme from human plasma. | The angiotensin I converting enzyme was purified 101 000-fold to homogeneity from human plasma by a combination of chromatographic and electrophoretic techniques. The enzyme is similar to other angiotensin I converting enzymes. It is an acidic glycoprotein consisting of a single polypeptide chain of molecular weight 14... | 200,263 | [
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Effects of isoproterenol on cyclic AMP and cyclic AMP-dependent protein kinase in developing chick myocardium. | Embryonic chick (7-9 day) and newborn chick myocardia contain one major peak of cyclic AMP-dependent protein kinase activity as assessed by DEAE-cellulose chromatography. Evidence is presented that the cyclic AMP-dependent protein kinase activity ratios (activity in absence of cyclic AMP/activity in presence of added c... | 200,278 | [
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[NAD-dependent formate dehydrogenase from methylotrophic bacteria. Isolation and properties]. | NAD-Dependent formate dehydrogenase (FDH) has been isolated from methylotrophyc strain Bacterium sp 1 by (NH4)2SO4 fractionation of cell extract, ion-exchange chromatography and preparative isotachophoresis. Preparation of FDH is homogeneous in analytical polyacrylamide gel electrophoresis and under ultracentrifugation... | 200,285 | [
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Poland syndrome: a concept of pathogenesis based on limb bud embryology. | A study of 15 patients as well as a review of the literature was made to determine the etiology of Poland syndrome. Neither the associated pathologic features nor any pattern of prenatal factors were helpful in revealing an etiology. A theory of primary nerve root dysgenesis was disproven. However, a concept of a local... | 200,291 | [
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Correlation of ovarian binding of 125I-HCG with formation of cAMP, estradiol and progesterone during pregnancy. | The content of ovarian gonadotropin receptors in rat was found to change during pregnancy. The specific binding of 125I-HCG to ovarian homogenates rose to its maximal values on days 13 and 16. Thereafter, the binding declined as parturition approached. No consistent changes in responsiveness of rat ovary to LH in synth... | 200,416 | [
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Effect of borate on the catalytic activities of muscle glyceraldehyde-3-phosphate dehydrogenase. | The effect of borate on glyceraldehyde-3-phosphate dehydrogenase from human, pig and rabbit muscle was studied. At lower concentration of borate only the dehydrogenase activity is inhibited, reversibly and competitively against NAD. At concentration of borate above 6 mM the plots of 1/v versus borate concentration beco... | 200,428 | [
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Effect of papaverine on cyclic nucleotide levels in the isolated rat aorta. | An increase in cAMP but no significant modification in cGMP content could be demonstrated in rat aorta strips after applying papaverine in concentrations which reduced contractile responses. Accumulation of cAMP was induced in noradrenaline-stimulated on K+-depolarized strips, under omission of external Ca2+. Thus the... | 200,442 | [
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Interaction of molybdate with copper(II)-histidine. | Molybdate and copper(II)-histidine form an insoluble complex of empirical formula Cu2(His)3(MoO4)2(H2O)2ESR-spectroscopy indicated that the complex had tetragonal symmetry. IR-spectroscopy showed the presence of a carboxylate anion and suggested that the molybdate ion formed an ammonium-type salt with the nitrogens of ... | 200,455 | [
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Cyclic AMP in neuroblastoma, ganglioneuroma and sympathetic ganglia. | Tissue content of cyclic AMP was as much as 10 times greater in ganglioneuroma than in neuroblastoma. This high cyclic AMP in ganglioneuroma was not significantly different from that of sympathetic ganglia. | 200,462 | [
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Increased spontaneous mitotic segregation in MMS-sensitive mutants of Saccharomyces cerevisiae. | Methyl methanesulfonate (MMS)-sensitive mutants of Saccharomyces cerevisiae belonging to four different complementation groups, when homozygous, increase the rate of spontaneous mitotic segregation to canavanine resistance from heterozygous sensitive (canr/+) diploids by 13-to 170-fold. The mms8-1 mutant is MMS and X-r... | 200,524 | [
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Effects of hypothalamic extract and corticosterone on incorporation of 14C-phenylalanine into newly synthesized ACTH-like protein in vitro. | The purpose of the present experiments was firstly, to examine the efficacy of the oxycellulose-Amberlite CG-50 extraction procedure for the isolation of rat pituitary ACTH and secondly, to study the effects of both hypothalamic extract and corticosterone on the synthesis of rat pituitary ACTH. Briefly, 'cold' rat pitu... | 200,539 | [
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New test for endotoxin potency based upon histamine sensitization in mice. | The results of a test of endotoxic potency based upon the development of histamine hypersensitivity in mice were compared with the results obtained by testing the same materials for pyrogenicity in rabbits and lethality for chicken embryos (CELD50). The results of the histamine hypersensitization test (HHT) correlated ... | 200,560 | [
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Isolation of infectious EB virus from the epithelial tumour cells of nasopharyngeal carcinoma. | Evidence of herpesvirus replication has been found by light and electron microscopy in the malignant epithelial cells of two out of six nasopharyngeal carcinomas (NPC) examined directly after growth in nude mice to eliminate non-malignant infiltrating cells. The agent has been identified as EB virus by immunofluorescen... | 200,568 | [
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... |
Virus expression in different tissues of normal and tumor-bearing mice inoculated with a murine leukemia virus. | Evolution of virus expression in different lymphoid organs as well as in solid syngeneic tumors of mice inoculated with an MuLV was studied with the aid of in vitro XC co-culture technique. When normal adult mice of strain XLII were inoculated intraperitoneally with a cultured Rauscher virus (RC), the virus could be de... | 200,574 | [
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... |
Arrhenoblastoma in a mare. | An ovarian neoplasm measuring 10 by 8 by 6 cm was surgically removed from a 14-year-old Appaloosa mare. For 2 years prior to surgery, the mare had manifested marked behavioral changes, becoming aggressive toward other broodmares. Histologically, the tumor was found to be an arrhenoblastoma. Preoperative endocrinologic ... | 200,593 | [
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Impaired intracellular migration and altered solubility of nonglycosylated glycoproteins of vesicular stomatitis virus and Sindbis virus. | Tunicamycin, an antibiotic which prevents the glycosylation of newly synthesized proteins, inhibits the replication of both vesicular stomatitis virus and Sindbis virus. In tunicamycin-treated infected cells, all of the viral proteins are synthesized but the glycoproteins are devoid of carbohydrate. The nonglycosylated... | 200,626 | [
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Mitotic activity of differentiated goldfish erythrophores in culture. | Integumental erythrophores on the scales of xanthic goldfishes were dissociated and cultured in a monolayer for about 30 days. The proportion of erythrophores in the culture was about 50% at the beginning of cultivation. Erythrophores in culture were characterized by the aggregate of orange-coloured pigment in the cent... | 200,631 | [
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Enzyme-linked immunosorbent assay for diagnosis of rotavirus infections in calves. | An enzyme-linked immunosorbent assay for the diagnosis of rotavirus infection in calves is described. The assay was more efficient for the detection of rotavirus antigens in calf feces than were electron microscopy and immunoelectroosmorphoresis. | 200,635 | [
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The effects of formocresol on rat sponge implant tissue: a biochemical study. | An investigation was conducted on the effect of formocresol treatment of the aqueous extractability and enzymatic susceptibility of excised implant tissue. The treated tissue demonstrated a decreased solubility and a diminished digestibility by trypsin, pepsin and collagenase. However, its reactivity toward hyaluronida... | 200,637 | [
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A test for the assessment of disinfectant/sanitizers used for napkin storage. | A test is described for assessing the effect of hypochlorites in reducing the bacterial load on soiled napkins during storage, between removal from the infant and laundering. | 200,674 | [
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Effect of dibutyryl cyclic AMP and oestradiol on incorporation of [3H]leucine into the proteins of luminal fluid of the rat uterus. | An injection of 12-5 nmol dibutyryl cyclic AMP (dbcAMP) into each uterine horn of ovariectomized rats maintained on progesterone alone, enhanced incorporation of [3H]leucine into uterine luminal proteins. A value of 11-73 X 10(3) c.p.m. [3H]leucine incorporated/rat was found after injection of dbcAMP compared with 3-6... | 200,692 | [
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... |
Testicular receptors for luteinizing hormone after immunoneutralization of gonadotrophin releasing hormone in the male rat. | The effects of immunoneutralization of endogenous gonadotrophin releasing hormone (GnRH) on the serum concentrations of testosterone and gonadotrophins and the binding of 125I-labelled human chorionic gonadotrophin (HCG) to testicular membrane fractions were studied in adult male rats. Four days after the administratio... | 200,695 | [
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The interaction of Herpes Simplex Virus with murine lymphocytes. I. Mitogenic properties of herpes simplex virus. | Herpes simplex virus (HSV) stimulates DNA synthesis in mouse spleen cultures prepared from normal, macrophage-depleted, and T-cell-depleted spleen cells, but not from thymocytes. In addition, a polyclonal antibody response is observed in HSV-infected spleen cultures. These findings indicate that the cells stimulated to... | 200,698 | [
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0.4460516,
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0.02693561,
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An assessment by competition hybridization of the sequence homology between the RNAs of the seven serotypes of FMDV. | A comparison has been made of the RNAs of the seven serotypes of foot-and-mouth disease virus (FMDV) by competition hybridization. Homology among the three European serotypes A, O, C and the Asia I serotype was 60 to 70%. Similar homologies were found among the three Southern African Territories serotypes (SAT I, SAT 2... | 200,707 | [
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0.1866886,
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Structural studies of encephalomyocarditis virus RNA both in situ and in free solution. | The secondary structure of encephalomyocarditis (EMC) virus RNA has been studied in situ and in free solution by absorbance-temperature relationships and by circular dichroism (CD). Extracted EMC virus RNA melts reversibly and has a hypochromicity of about 20%; analysis of CD spectra and formaldehyde treatment suggests... | 200,710 | [
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... |
Immunosuppression reactivates and disseminates latent murine cytomegalovirus. | When searched for by standard virological methods, murine cytomegalovirus (MCMV) becomes undetectable by 4 months after inoculation of mice. However, a 2-week regimen of immunosuppression with antilymphocyte serum and corticosteroid results in reactivation and dissemination of the virus in virtually all animals. This s... | 200,714 | [
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0.06379507,
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A micro-electrode study of peripheral neuropathy in man. Part 2. Responses to conditioning stimuli. | Surface, needle and micro-electrode recordings were obtained from sensory nerves of patients with various types of peripheral neuropathy. Changes in amplitude and conduction velocity of nerve action potentials were measured after a single conditioning stimulus and after tetanic stimulation for 2 min. In patients with h... | 200,718 | [
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0.216333,
0.1813715,... |
Effect of diet restriction on some key enzymes tryptophan-NAD pathway in rats. | Dietary intake of rats was restricted by feeding varying amounts of a 20% protein diet. After 6 weeks of feeding, some key enzymes of the tryptophan and nicotinic acid-NAD pathway, liver nicotinamide nucleotide concentration, and urinary metabolites of tryptophan and nicotinic acid were studied. With an increase in die... | 200,723 | [
-0.004961373,
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0.03415713,
0.1256713,
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0.01389386,
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0.2641421,
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-0.06576958,
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0.5014706,
-0.202065... |
Transmission from photoreceptors to ganglion cells in turtle retina. | 1. Synaptic transfer between photoreceptors and impulse-generating cells was studied in isolated eyecups from turtles. Single red-sensitive cones or rods were stimulated by current passed through an intracellular electrode, and impulses generated by the resulting synaptic action were recorded with an external micro-ele... | 200,736 | [
0.06328814,
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0.2400377,
0.1167405,
0.02243855,
0.2318998,
0.1691185,
0.2108496,
... |
[Myocardial function in patients with congenital pulmonary valve stenosis]. | The studies of metabolism and morphology of the myocardium, and of ECG parameters in 72 patients with valvular pulmonary stenosis conducted with biopsy and autopsy material has demonstrated that while the workload on the right ventricle grows and the severity of the pathological process increases, the oxidative capacit... | 200,784 | [
-0.06200663,
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0.03887026,
0.1623914,
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-0.5775988,
0.1673657,
0.1590587,
0.472378,
0.3943868,
0.04182421,
-0.167763... |
[Classification and supervision of hyperlipemias (author's transl)]. | Different methods for determination and classification systems of serum lipoproteins were used and compared in 300 patients with hyperlipidemia. The procedures and methods were examined to find out which would provide a useful classification for diagnosis and therapy. Lipid electrophoresis on agarose gel gave no reliab... | 200,839 | [
0.1470293,
0.3620421,
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0.04383866,
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0.440403,
0.556933,
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0... |
[Operative possibilities for tumors in single kidneys with particular reference to in situ perfusion (author's transl)]. | Surgical removal of malignant tumors from a single kidney is definitely a problem which can be solved by modern techniques of urological surgery. The different operation techniques in 5 of the patients operated on in the Urologische Universitätsklinik Giessen are presented and discussed. In the individual case, besides... | 200,840 | [
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0.03918374,
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0.1126426,
0.2601142,
0.02849557,
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... |
Characterization of a common precursor to corticotropin and beta-lipotropin: cell-free synthesis of the precursor and identification of corticotropin peptides in the molecule. | mRNA was isolated from cultures of AtT-20/D-16v tumor cells and translated in a mRNA-dependent reticulocyte cell-free system. The corticotropin (ACTH) product was purified by a double-antibody immunoprecipitation procedure using antisera specific for the alpha(1-24) sequence of ACTH. The product is shown by sodium dode... | 200,934 | [
-0.175371,
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0.1943181,
0.04976547,
0.3437183,
0.4096551,
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Regulatory function of simian virus 40 DNA replication for late viral gene expression. | Inhibition of simian virus 40 (SV40) DNA synthesis prevents late but not early viral gene expression in infected cells. To test whether the late SV40 template specificity is elicited by replicative intermediate DNA molecules (RI-DNA), we isolated subcellular fractions containing RI-DNA from SV-40-infected monkey cells ... | 200,935 | [
-0.05079961,
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0.4054394,
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0.3505638,
0.2425261,
0.07000446,
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-0.275911,
-0.078006,
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0.1557214,
0.4001419,
0.1722074,
-0.16556... |
Simian virus 40-specific proteins in the membranes of simian virus 40-transformed hamster and mouse cells. | Membranes of simian virus 40-transformed hamster lymphocytes and phagocytes, as well as of transformed mouse fibroblasts, contain two classes of antigenic virus-specific protein. The isoelectric points of these proteins, as defined by isoelectric focusing/immune electrophoresis are at pH 4.5 and 4.7. The molecular weig... | 200,945 | [
-0.318339,
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0.4575614,
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0.05075018,
0.007892817,
0.3158783,
0.1179093,
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0.061038,
0.01430502,
0.08762068,
-0.1315508,
0.1770601,
-0.07137887,
... |
Structural correlates of arterial endothelial permeability in the Evans blue model. | Normal young pigs were injected intravenously with azo dye Evans blue, which is preferentially and consistently taken up by focal areas in the aorta known to be areas of enhanced permeability. Ferritin was intravenously injected into these animals, and its uptake was quantitated at the electron microscope level at 1, 5... | 200,955 | [
-0.3035841,
0.03510967,
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0.06261139,
0.460245,
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0.188194,
0.2373043,
0.066062,
0.007482809,
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-0.3720399,
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0.1033281,
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0.1243255,
-0.08844663,
0.2346068,
0.09059393,
-0... |
Computed tomographic demonstration of hepatic tumor with the aid of intravenous iodinated fat emulsion. An experimental study. | Computed tomography showed improved visualization of carcinogen-induced hepatoma in monkeys following intravenous injection of an experimental contrast material AG 60-99; selective opacification of the liver and spleen was accomplished with a dose of greater than or equal to 0.1 ml/kg, a fraction of the dose used in co... | 200,969 | [
-0.2021159,
0.1521473,
-0.3125818,
-0.1756298,
0.3290682,
0.01796452,
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0.1869705,
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-0.2714276,
0.1075208,
0.04172489,
-0.463047,
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-0.3353936,
-0.0561273,
-0.042385,
0.4809,
0.04143488,
0.1852549,
-0.1474533,
0.2... |
Comparison of laboratory performance with blind and mail-distributed proficiency testing samples. | Simulated addict urine samples containing drugs were sent to collaborating hospital administrators and officials of methadone centers, who then forwarded the samples to their supporting laboratories as though they were ordinary specimens from patients. The laboratories, which were already participating in the proficien... | 200,968 | [
-0.310225,
0.110713,
-0.2480595,
-0.1487602,
-0.01845673,
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0.1226035,
0.08590402,
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0.2514971,
0.3989003,
0.2447616,
0.4411014,
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0.02186873,
-0.06831474,
-0.1113528,
0.1544347,
0.08523808,
-0.1561128,
0.142483,
-0.... |
Cyclic AMP-dependent protein kinase activation in hearts from euthyroid and hyperthyroid rats. | The degree of cyclic AMP-dependent protein kinase activation in response to dibutyryl cyclic AMP and norepinephrine was determined in samples of rat heart obtained from hyperthyroid and euthyroid animals. The data indicate that thyroid hormone-induced supersensitivity to the metabolic effects of the catecholamines cann... | 200,995 | [
-0.1022038,
-0.3874826,
-0.3300718,
-0.3459329,
0.09740911,
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0.2670439,
0.277274,
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-0.4504898,
-0.05623675,
-0.1966246,
0.05219604,
0.3479395,
0.1726554,
-0.1960967... |
[Clinical, radiological and bacteriological study of pulmonary tuberculosis with bacteria showing drug resistance]. | The authors have investigated two groups of patients of young age suffering from tuberculosis with germs showing primary resistance to chemotherapeutic agents (61 cases), and with germs displaying sensitivity to these agents (64 cases). The following conclusions have been reached: tuberculosis with germs showing primar... | 201,007 | [
0.02483506,
-0.03206373,
0.1189959,
0.08824436,
-0.01554008,
-0.2784763,
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0.03437183,
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0.148468,
0.252681,
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0.1126447,
-0.7051851,
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-0.1098656,
0.1350682,
-0.0894025,
0.5282316,
0.3557904,
0.2017569,
-0.1140207,
0.... |
Isozymes of creatine phosphokinase and myokinase in human heart and skeletal muscle. | The isozyme patterns of creatine phosphokinase (CPK) and myokinase (MK) were investigated in biopsy material from human heart and skeletal muscle. The protein separation was performed on crude muscle homogenates by means of flat-bed isoelectric focusing. Two isozymes were demonstrated for each enzyme, irrespective of t... | 201,021 | [
-0.1011935,
0.3847312,
-0.2444329,
-0.1684585,
-0.01663166,
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0.02334208,
0.4634037,
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0.2710614,
0.009588135,
0.110907,
0.2584831,
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-0.08128943,
0.3857175,
0.07932589,
0.4570382,
0.1203055,
-0.09873053,... |
Structural basis for on-and off-center responses in retinal bipolar cells. | Electron microscopy of Golgi preparations of goldfish retina shows that dendrites of type a (hyperpolarizing, off-center) bipolar cells make wide cleft junctions unassociated with synaptic ribbons, while those of type b (depolarizing, on-center) bioplar cells make narrow cleft junctions and synaptic ribbon contacts, wi... | 201,028 | [
0.1543557,
-0.09134184,
-0.4163977,
-0.1105354,
-0.0477047,
-0.208931,
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0.07983687,
0.2501445,
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-0.518532,
0.1532359,
0.2818343,
-0.3319313,
0.1955541,
0.4458776,
0.0536691,
-0.... |
[Muscular and nervous system manifestations of Graves' disease]. | A study of 30 cases of Grave's disease confirmed the frequency of hyperthyroid myopathy, whether obvious or revealed by E.M.G. More than by the association of various symptoms (pretibial myxoedema, antithyroid antibodies), we were struck by the multiple symptoms of Grave's disease with myopathy, which confirms the angl... | 201,029 | [
0.04746699,
-0.4692364,
0.02926241,
-0.0435757,
-0.0627069,
-0.2091616,
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0.1314627,
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0.09112819,
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0.2683145,
0.1701802,
0.02231969,
0.4140578,
-0.1000704,
-0.1424569,
... |
Effects of dibutyryl cyclic-AMP on cardiac output and myocardial contractility in dogs. | Dibutyryl cyclic-AMP was administered to a group of anesthetized dogs at the doses of 5, 10, 20 and 40 mg/kg, and changes in stroke volume, cardiac output and myocardial contractility were observed. Also, effects of this substance on contractile performance of isolated cardiac muscle were investigated in another group ... | 201,047 | [
-0.4209087,
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-0.2808712,
-0.3422978,
0.229788,
-0.5852578,
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0.2061069,
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0.1128336,
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0.4399142,
-0.2033011,
0.4896254,
0.07454947,
-0.1193124,
-0.2132092,
... |
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