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patients with cancer who undergo complex treatments may experience psychological distress , but it is often unrecognized , and if left untreated may contribute to poor health outcomes among patients and their | 0 |
( the woodlands , tx ) as previously described ( 6 ) . sglt2 and db / db backcrosses were performed at the jackson laboratory ( bar harbor , me ) and | 0 |
conformational changes in a molecule are implicated in many biological processes . for example , during transcription rna polymerase recognizes and binds to a promotor region on double - stranded dna ( | 0 |
da : i have a relatively broad area of scientific interest encompassing cancer genetics , mouse genetics and genome sequencing . with my cancer hat on , the paper that impressed me | 0 |
female mice ( c57bl/6j strain ) 6 to 8 weeks old were obtained from jackson laboratory ( bar harbor , me , usa ) . female tlr4ko mice used in the study | 0 |
this article investigates the correlates of the timing of transition into motherhood among adolescent girls in two informal settlements or slums korogocho and viwandani in nairobi city , kenya . other markers | 0 |
solution ph is one of the most important environmental variables that affects the structural and dynamic properties of biomolecules . various biological events such as protein folding / unfolding , ligand binding | 0 |
understanding transport properties of fluid molecules in microporous materials is of great importance due to intriguing features of fluidic phenomena at the nanoscale . many industrial and scientific applications such as gas | 0 |
at indiana universitypurdue university indianapolis ( iupui ) , we have developed a concept called distributed drug discovery ( d ) . herein is reported the first example of a key component | 0 |
every year more than 14 million cases of obstetric hemorrhage occur , resulting in an estimated 127,000 deaths.1 postpartum hemorrhage ( pph ) , blood loss of 500 ml or more , | 0 |
the genus flavivirus currently includes 86 viruses , of which 73 are grouped into 53 species ( 1 ) . more than 40 of these flaviviruses are known to be pathogenic for | 0 |
generation of 3-mb - pp13-mb - pp1 was synthesized using a previously described route with slightly modified conditions ( 18 ) . p116 , a zap-70-deficient jurkat - derived t cell line | 0 |
although considered the gold standard for evaluating treatment effectiveness , randomized clinical trials ( rcts ) have important limitations . because randomization removes potential bias from unknown and unmeasured confounders , observed | 0 |
according to the estimation of world health organisation , there are about 240 million people who are chronically infected with hepatitis b virus ( hbv ) . the chronic hbv infection is | 0 |
historically , the taming of singularities in classical field models has driven a great deal of research . a particularly elegant example is the nonlinear extension of maxwell electrodynamics introduced by born | 0 |
kohn sham density - functional theory ( ks dft ) is the method most widely used in electronic structure calculations , due to its modest computational cost combined with an accuracy that | 0 |
jack ( 35 ) , a college teacher and a father of two children aged 5 and 13 years , has been a jehovah s witness as long as he can remember | 0 |
all pcos patients met all three criteria of the revised 2003 rotterdam european society of human reproduction and embryology ( eshre)/american society of reproductive medicine ( asrm ) pcos consensus workshop group | 0 |
eu2o3 doped zno films are deposited on cleaned quartz substrate at room temperature ( 300 k ) using radio frequency ( rf ) magnetron sputtering technique ( rf frequency : 13.56 mhz | 0 |
the embl ( european molecular biology laboratory ) nucleotide sequence database ( often referred to as the embl database ) is hosted at the european bioinformatics institute ( ebi ) . it | 0 |
patients with congestive heart failure ( hf ) are at high risk of dying from its progression as well from sudden cardiac death related to ventricular tachyarrhythmia . over the last decade | 0 |
a growing body of empirical evidence suggests that the origins of obesity and metabolic dysfunction can be traced back to the intrauterine period of life , at which time the developing fetus | 0 |
the 1978 alma ata declaration codified the right to primary health care ( phc ) for all . nine years later , african ministers of health convened in bamako , mali , | 0 |
based on international surveys during the past forty years , the prevalence of overweight or obesity in children has accelerated in most global regions . latest available estimates from 34 member countries | 0 |
generalized anxiety disorder ( gad ) is a chronic disorder mainly characterized by pathological worry . gad also presents with a variety of somatic and psychological symptoms such as restlessness , muscle | 0 |
review articles in the scientific literature can be classified as a general review article , a systematic review ( sr ) , or meta - analysis ( ma ) . the purpose | 0 |
the crystal structures of materials are traditionally investigated by the long - range phenomenon of bragg diffraction and described by unit cells that represent the average structure . atoms in the structure | 0 |
walker 's cay , is a minute tropical island in the northernmost part of the bahamas archipelago of a size barely sufficient for a runway , a lodge and a harbor . | 0 |
adult male wistar rats ( harlan , indianapolis , in ) were housed in individual cages under specific pathogen free conditions , maintained in a temperature - controlled room with a 12:12-h | 0 |
rapid advances in the crystallographic determination of transmembrane ( tm ) protein structures , and especially of g - protein coupled receptors ( gpcrs ) , have established the lipidic cubic phase | 0 |
this study was approved by the institutional review boards of the participating centers , according to the tenets of the declaration of helsinki . informed consent was obtained from all patients at | 0 |
endometriosis is an estrogen - dependent chronic inflammatory condition that affects women in their reproductive period , and is associated with pelvic pain and infertility . this gynecologic condition has a prevalence | 0 |
conventional lentiviral vectors based on hiv-1 establish permanent genetic modification of target cells owing to the fact that their integrase - dependent mechanisms ensure semirandom chromosomal insertion of the transported foreign nucleic | 0 |
the theme of infanticide has received increasing attention from historians in recent years . reasons for this growing interest include curiosity into the daily lives of poor women , and also the | 0 |
the mental health care bill 2013 was introduced to the rajya sabha , india 's upper house of parliament , on 19 august 2013 . the legislation aimed to provide for mental | 0 |
a couple s intentions to have a number of descendants can be thwarted in a number of ways . the most difficult of factors are those that are restrictive and outside of | 0 |
an estimated 66% of maternal deaths and 50% of deaths in children under the age of 5 occurred in sub - saharan africa in 2015 [ 1 , 2 ] . although | 0 |
celem niniejszej pracy jest przedstawienie obecnej taktyki postpowania zarwno diagnostycznego , jak i terapeutycznego u chorych z pseudotorbielami oraz torbielowatymi guzami trzustki . praca zostaa napisana na podstawie materiau zebranego i przygotowanego | 0 |
coccidia are a diverse group of protozoan parasites within the phylum apicomplexa and include pathogenic species of significance to animal and human health . atoxoplasma ) , primarily parasitize a single host | 0 |
specific fibril aggregation of more than 20 proteins has been linked to a pathogenesis of many amyloid - associated diseases such as alzheimer s disease , parkinson s disease , huntington s | 0 |
nanotechnology has the potential to create new materials and devices with wide - ranging applications in medicine,13 agriculture,4 and energy or electronic production.5,6 the size - dependent optical , electrical , and | 0 |
concomitant chemo - radiotherapy , mainly with cisplatin is the standard combined modality approach for the treatment of patients with locally advanced squamous cell carcinoma of the head and neck ( scchn | 0 |
protection of human health and the environment is one of the major challenges facing developing as well as developed countries of the world [ 15 ] . the original aim of regulating | 0 |
musculoskeletal conditions , or disorders of the muscles and bones , are the most common causes of chronic disability in the world . in the us alone , disease of the musculoskeletal | 0 |
preconference workshop a : the nuts and bolts of antibody development : accelerating antibody drugs to the clinic . co - chairs : james larrick ( panorama research institute and velocity pharmaceutical | 0 |
during the aging process , increasing disturbances in the functioning of cells and organs occur . presbyacusis , or age - related hearing loss , is caused by involutionary changes in the | 0 |
poly(vinyl alcohol ) ( pva ) is a biocompatible polymer with a great variety of biomedical and pharmaceutical applications . pva in aqueous solution is able to form chemical or physical gels | 0 |
inadequate organization has been identified as an important cause of inappropriate courses of treatment for patients in the health care system [ 1 , 2 ] . a response to this challenge | 0 |
these adverse outcomes are common , for example lenke and levy reported that in women with phe levels > 20 mg per decilitre , 73% had microcephaly and 92% of children had | 0 |
arnt - floxed ( arnt ) ( 9 ) and hif1-floxed ( hif1 ) ( 10 ) mice containing loxp sites flanking exons 6 and 1315 , of the arnt and hif1 | 0 |
reactions in which a cyano ( cn ) radical abstracts a hydrogen atom from an organic molecule present an unusual opportunity to contrast chemical reaction dynamics under isolated conditions and in the | 0 |
occupancy of a wide range of g - protein - coupled receptors and receptor tyrosine kinases triggers the hydrolysis of phosphatidylinositol 4,5-bisphosphate ( pip2 a ) , aabbreviations : pkc , protein | 0 |
we constructed a decision tree cost - effectiveness model for a target population of 163,000 women who at the time of the intervention are sexually active with a male partner , fertile | 0 |
because steroid hormones play an important role in a wide range of physiological processes , the potential to disturb endocrine effects is a major concern in the development of novel pharmaceutical drugs | 0 |
enhancing the binding potency of carbohydrate inhibitors of protein carbohydrate interactions is an important step towards improved medicinal applications.1 this is mostly the case because of the relatively weak interactions between proteins | 0 |
type 2 diabetes mellitus ( t2 dm ) is a progressive disease , meaning that most patients will require the introduction of insulin into their treatment regimen at some point during the | 0 |
exposures to ambient air pollution and secondhand smoke ( shs ) have been implicated as health risks , particularly for some conditions such as asthma ( chilmonczyk et al . , ; | 0 |
a global upsurge in human life expectancy and the recent phenomenon of late - life mortality deceleration have contributed to a higher demand for long - term care.1,2 accordingly , an increasing | 0 |
epilepsy is generally deemed intractable or refractory to treatment if the use of two or more appropriately chosen antiepileptic drugs ( aeds ) fails to adequately control seizures . the aeds in | 0 |
alzheimer 's disease ( ad ) is a common neurodegenerative disease in the central nervous system . the pathological features of ad include senile plaques formed by extracellular amyloid ( a ) | 0 |
parkinson 's disease ( pd ) is an age - related neurodegenerative disease with progressive loss of dopaminergic ( da ) neurons in the substantia nigra pars compacta ( snpc ) . | 0 |
male wistar rats ( 150200 g ) were obtained from b&k universal , sollentuna , sweden . animals were housed under a 12-h light/12-h dark cycle and had free access to water | 0 |
the fusion between the sperm and the egg marks the beginning of a new individual and ensuing development of either man or beast depends upon a number of additional cell fusion events | 0 |
physical stimuli can significantly alter cellular behavior , giving rise to biochemical signals involved in molecular response.1 this process is called mechanotransduction , and the responsible structures sensitive to mechanical forces are | 0 |
accurate attribution of co2 variability is required to constrain coupled models combined influence of drought and fire exceed ecosystem responses to temperature temporal and spatial smoothing of co2 observations masks variability from | 0 |
we adopt a simple cvd process , the salient stages of which are outlined in figure 1 : ( 1 ) the preannealing stage , during which the samples are gradually heated | 0 |
subjects are mexican american ( both parents and 3 grandparents mexican or of mexican descent ) who are either probands with gdm diagnosed within the previous 5 years and diagnosed in their | 0 |
blood was recovered from 14 individuals with type 2 diabetes who arrived in our patient clinic ( sex [ m / f ] , 8/6 ; a1c , 8 1.2% ; age | 0 |
macroautophagy , which we will refer to as autophagy , is a highly conserved catabolic process in which cytoplasmic proteins and organelles are engulfed by double - membrane structures called autophagosomes , | 0 |
accurate and automatic segmentation of medical images is an essential component of a computer - aided diagnosis ( cadx ) system . however , medical image segmentation is typically a difficult task | 0 |
to assess the correspondence between distinct basal ganglia pathways and hypothesized cognitive processes , we applied the high spatio - temporal resolution of single - unit electrophysiology to a stop - signal | 0 |
current generation composite , light - weight , combat helmets provide enhanced fragmentation and ballistic protection , generally with reduced weight in comparison to previous generations of combat helmets . previous generations | 0 |
the relationship between mind and matter has been a fundamental topic of investigation in many if not all cultures and traditions since the most ancient records of human thought , from the | 0 |
administratively , the ladakh region in the state of jammu and kashmir ( india ) is divided into two districts : the western kargil district and the eastern leh district . this | 0 |
cone dystrophy is a type of hereditary retinal degeneration characterized by a progressive dysfunctioning of the cone photoreceptors . the possibility of cone dystrophy confined mainly in the periphery had been suggested | 0 |
it has been shown that interictal epileptiform discharges ( ieds ) observed from eeg constitute useful markers of epileptogenesis in patients with focal epilepsy . the regions inside the brain from which | 0 |
the nonclassical hla - g molecule presents several properties that differ from other classical class i hla ( -a , -b , and -c ) molecules , including restricted tissue distribution ; | 0 |
differential quantification of complex mixtures using high - performance liquid chromatography coupled to electrospray ionization and tandem mass spectrometry ( hplc esi ms / ms ) can help researchers study biological variation | 0 |
by 2050 , there will be approximately 2 billion people aged 60 years or more and the number of older people will outnumber the young . the most rapid changes will take | 0 |
the genetic composition of a natural population is always changing because mutations inevitably arise and rise or fall in frequency due to selection or drift ( i.e. stochasticity in finite populations ) | 0 |
pathogens on invading host cells express molecules that are broadly shared by all microbes and distinct from host . these include lipopolysaccharide , peptidoglycan , flagellin and microbial nucleic acids , and | 0 |
systemic lupus erythematosus ( sle ) is a systemic autoimmune disease with manifestations in multiorgans that are induced by the deposition of circulating autoantibody - autoantigen complexes ( immune complexes , ic | 0 |
sh2b1 knockout and tgko mice have been described previously ( 29,31 ) and were backcrossed for six generations onto a c57bl/6 genetic background . mice were housed on a 12-h light / | 0 |
strains and media bacteria and plasmids used in this study are listed in supplemental table s1 . l. pneumophila was grown on cye agar plates or in aye broth ; escherichia coli | 0 |
the earliest evidence for protein quality control at the er came from observations that unassembled subunits of the t cell receptor were rapidly degraded in the cells ( lippincott - schwartz et | 0 |
many studies over the past 15 years have focused on discovering solvents that help promote efficient cc bond formation under benign reaction conditions . new solvents in dielsalder(2 ) and barbier reactions | 0 |
although the neurotoxic action of lead is known for centuries , it has not yet been adequately elucidated which effects would be useful early indicators of a clinically latent lead intoxication . | 0 |
stress is a biologically important and ubiquitous circumstance that can influence brain functions . because of the importance of both the beneficial and deleterious effects of acute and chronic stresses on cognitive | 0 |
the aspergilli are filamentous fungi , which are multicellular eukaryotes with a relatively simple life cycle . many of them have long been used in food production , industrial fermentation , and | 0 |
medullary thyroid carcinoma ( mtc ) is a rare neuroendocrine cancer that originates from thyroid parafollicular calcitonin-(ct- ) producing cells . mtc accounts for approximately 4% of all thyroid malignancies ; approximately | 0 |
i refer the reader to several fine reviews on avian skin epithelial stem cells ( chuong et al . , 2006 ) and other stem cells of the mammalian skin ( nishikawa | 0 |
since first reported by kondo and uchiyama in 1999 , di - tert - butyl - tmp zincate lizn(tmp)bu2 ( tmp = 2,2,6,6-tetramethylpiperidide ) has proven to be a powerful and effective | 0 |
the exploration of patterns and relationships in large health statistics and survey data is always a difficult data analysis task due to the volumes of data collected . examples of widely used | 0 |
the majority of cellular proteins exist as symmetric oligomers with distinct biochemical and biophysical properties , which often provide the means for additional regulation of their function at the post - translational | 0 |
leishmaniasis is a parasitic disease that can manifest in three forms : 1 ) mucosal , 2 ) cutaneous , and 3 ) visceral ( who 2010 , maroli et al . | 0 |
writing about the interdisciplinary study of dying , kellehear ( 2009 ) argues that there is a great deal which the current knowledge base can not tell us about dying experiences . | 0 |
after the implementation of the first prenatal care in the late 1930s in england and northern ireland ( 1 ) , little by little , it has become recognized that there is | 0 |
genome sequencing has revealed that most higher eukaryotes have a relatively limited set of genes , whose numbers do not correlate with organismal complexity . the ability of a limited number of | 0 |
male sprague - dawley rats ( charles river , wilmington , ma ) of 220250 g were housed in the yale animal resource center , fed a standard pellet diet ( prolab | 0 |
the paternal contribution to an embryo plays an important role in understanding early developmental processes and their effect on the health of a child . sperm cells are highly differentiated , polarized | 0 |
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