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charcot marie tooth disease ( cmt ) is a clinically and genetically heterogeneous group of sensorimotor peripheral neuropathies and represents the most frequent inherited disorder(s ) affecting the nervous system . in | 0 |
approximately 40 million people are infected with the human immunodeficiency virus ( hiv ) worldwide ( unaids 2006 ) . infections by this lentivirus from the family retroviridae are characterized by a | 0 |
this study was approved by the institutional review board of the duke university health system , and all subjects participated with full informed consent . a group of 14 ophthalmic surgeons - | 0 |
determining and characterizing past exposures to chemicals and physical agents is a vexing but essential challenge in industrial hygiene , pathology , occupational medicine and epidemiologic research . in particular , cumulative | 0 |
evidence is growing in support of a role for infections in the aetiology of childhood leukaemia , particularly for the most common subtype , acute lymphoblastic leukaemia ( all ) . two | 0 |
thirty years have passed after discovering human immunodeficiency virus ( hiv ) , the etiological agent of the acquired immunodeficiency syndrome ( aids ) [ 14 ] . two types of hiv | 0 |
functional residual capacity , frc , is the lung volume at the end of a relaxed expiration to atmospheric pressure . the frc is affected by lung diseases and thus is a | 0 |
vaccines are one of the most successful medical interventions in human history and estimated to prevent more than 2.5 million deaths every year [ 1 , 2 ] . in essence , | 0 |
the state of non - rem sleep ( nrem ) , or slow wave sleep , is associated with a synchronized eeg pattern in which specific electrographic events take place . these | 0 |
procedures involving animals were approved by the animal care and use committee of the schepens eye research institute . male sprague - dawley rats ( 5 weeks of age ; taconic farms | 0 |
the fundamental principles of pay - for - performance include rewarding quality health care and aligning physicians financial incentives with the best interests of patients.9 although this inherent appeal to physician self | 0 |
while advances in free trade and globalization increase the movement and accelerate the accumulation of invasive species ( lockwood et al . 2005 ) , it is still unclear how introduced populations | 0 |
to develop methods for mapping a qtl to a phylogenetic tree , we begin with several simplifying assumptions : the taxa are represented by inbred lines , the tree relating the taxa | 0 |
health services and health policy research can be based on qualitative research methods , especially when they deal with a rapid change and develop a more fully integrated theory base and research | 0 |
nine male competitive cyclists participated in this study . their mean sd age , height , and body mass were 33.3 7.5 yr , 184 4 cm , and 77.3 7.0 kg | 0 |
both types of diabetes mellitus can be a lead cause for blindness , kidney failure , neuropathic diseases , foot ulceration , gas gangrene in lower limbs , foot amputations , and | 0 |
efforts have been ongoing in many countries to develop integrated ecosystem - based assessments using physical chemical properties , biological abundance and diversity , and/or chemical characterisation to define the ecological quality | 0 |
readers of this review should consider that many age - related processing speed findings reported in the literature are cross - sectional in nature , including the primary findings reviewed here . | 0 |
alzheimer s disease ( ad ) is a progressive neurodegenerative disease that is clinically characterized by impairment of cognitive and functional abilities together with behavioral symptoms . the diagnosis of probable ad | 0 |
bromodomain modules selectively recognize acetylated lysine ( kac ) containing sequences , a post - translational modification that is highly abundant in histones and other nuclear proteins . interest in these so | 0 |
access to automated dna sequencing technology has made possible the rapid generation and analysis of gene transcripts expressed in organisms via expressed sequence tags ( ests ) . this information has helped | 0 |
the igf system plays crucial roles in biological processes such as proliferation , differentiation , invasion , tumor expansion , migration , and survival . it can be used to predict clinical | 0 |
impairments in attention , cognitive control , and speed of information processing have been frequently observed after traumatic brain injury ( tbi ; stuss et al . , 1989 ; spikman et | 0 |
prostatic acid phosphatase ( pap ) , a glycoprotein synthesized by the prostate gland , is traditionally used to diagnose prostate cancer . pap has two isoforms , secreted and transmembrane isoforms | 0 |
health systems based on primary health care ( phc ) distribute health care more equitably , are more cost effective and have better overall health outcomes and impact than health systems based | 0 |
the advent of antihypertensive therapy has substantially reduced the occurrence of cardiovascular events . however , antihypertensive therapy failed to achieve blood pressure control in all patients , with hypertension control rates | 0 |
superparamagnetic iron oxide nanoparticles ( nps ) , with core diameters of 315 nm , are used in a rapidly expanding number of applications in the biomedical field ; the most common | 0 |
gypsies and travellers are recognized as one of the most disadvantaged minority groups in the united kingdom and globally . research into the health needs of this group is an emerging field | 0 |
rna interference ( rnai ) achieved by double - stranded rna ( dsrna ) mediated sequence - specific breakdown of the mrna ( fire et al , 1998 ; montgomery and fire | 0 |
the importance of early and intensive control of blood glucose levels in improving outcomes for people with type 2 diabetes mellitus ( t2 dm ) was established in the uk prospective diabetes | 0 |
the advent of multislice ct technology with ecg - gating along with innovations in x - ray tube and ct detector technology have resulted in revolutionary progress in cardiac imaging . ecg | 0 |
the aim of the present investigation was to develop an instrument to monitor any changes in maternal and neonatal health ( mnh ) care provider motivation resulting from the introduction of pilot | 0 |
as a medical specialty , pathology generates and interprets laboratory data on fluid and tissue specimens . the data generated and interpretations rendered must be accurate , reproducible , and presented in | 0 |
flavo - diiron proteins ( fdps ) are widespread in microaerophilic and anaerobic microorganisms , including bacteria , archaea , and a few protozoan parasites . the accumulated genetic and biochemical evidence | 0 |
details on real - time quantitative reverse transcription - pcr ( qrt - pcr ) and primers are provided with supplementary material , table s1 , and details on immunoblotting , flow | 0 |
they are subjected to continuous operation of stressful factors caused by the exploitation of the roads . these are mainly emissions , dust from the wear of tires and the clutch disc | 0 |
protein lysine methyltransferases ( pkmts , also known as histone lysine methyltransferases ( hkmts ) ) catalyze the transfer of the methyl group from the cofactor s - adenosyl - l - | 0 |
h bonds in complex molecules represents a most useful but also one of the most challenging transformations in organic chemistry . over the past two decades , notable advances in the area | 0 |
it is essential for all living organisms to warrant accurate functioning and propagation of their genetic information . however , the genome is constantly exposed to various environmental and endogenous agents , | 0 |
successful management of moderate - to - severe copd can be accomplished with combination therapy that delivers a concurrent dose of inhaled corticosteroid and a long - acting 2-agonist ( ics / | 0 |
dna - protein interactions are involved in several biological processes like transcription , replication , dna repair , or recombination . the variety of these mechanisms involves variations of the electrostatic potential | 0 |
the human stratum corneum ( sc ) is a superficial continuous membrane made of tightly stacked corneocytes parted by multilamellar lipid sheets . its deep cohesive portion is called the stratum compactum | 0 |
in a number of reviews on the induction of bone formation , we have often asked how bone differentiation by induction is initiated ? or how the soluble molecular signals of the | 0 |
the observation at the lhc of a higgs particle with a mass of 125 gev [ 1 , 2 ] has important implications for supersymmetric ( susy ) and , in particular | 0 |
idiopathic dilated cardiomyopathy ( dcm ) is a heart muscle disorder characterized by systolic dysfunction and dilation of the left or both ventricles in the absence of any other possible cause.1 dcm | 0 |
hepatitis c virus ( hcv ) infects 175,000,000 people worldwide and is a major cause of morbidity and mortality ( 1 , 2 ) . in the united states , recent advances | 0 |
tim catalyzes the conversion of dihydroxyacetone phosphate ( dhap ) to ( r)-glyceraldehyde 3-phosphate ( gap ) , by proton transfer reactions at carbon , through enzyme - bound cis - enediolate | 0 |
the extent to which computerized provider order entry ( cpoe ) systems significantly hinder or assist clinical work efficiency has been a subject of debate and investigation for over 20 years . | 0 |
over the past several decades people have been constantly exposed to electric ( e ) and magnetic ( h ) fields from both industrial and domestic uses . the emfs are produced | 0 |
in recent years , nanoparticles have been used increasingly for biomedical applications , including drug or gene delivery , imaging , sensing , or photothermal therapy . in particular , gold nanoparticles | 0 |
the ability to treat bacterial infection is critical to modern medicine , from abdominal surgery to transplants to cancer management . without antibiotics , these procedures would be unthinkable owing to the | 0 |
the chemistry of heavier carbene analogues has attracted the attention of both experimentally and theoretically oriented chemists over the last decades . the fundamental differences in electronic ground states , reactivities , | 0 |
it integrates signals from cortical areas and subserves important functions like motor control ( tecuapetla et al . , 2014 , kravitz et al . , 2010 ) and reinforcement / punishment | 0 |
they cause significant morbidity through a compression of regional structures and an inappropriate expression of pituitary hormones that disturb the multiple hypothalamic - pituitary - target organ axis systems . pituitary adenomas | 0 |
cooperative catalysis between thioureas and brnsted acids , whereby the enhanced catalytic activity of the thiourea acts as an acid amplifier , has successfully been applied to asymmetric catalysis , and more | 0 |
four cohorts contributed to the discovery meta - analysis through the contribution of phenotypic and gwas data . these included the framingham heart study ( n = 5,759 ) , precocious coronary | 0 |
protein protein interactions ( ppis ) play a critical role in many biological processes and in a broad spectrum of human diseases , including cancer , and small - molecule modulators of | 0 |
there has been a dramatic increase in the proportion of babies with congenital heart disease ( chd ) surviving to adulthood . advances in pediatric surgery and pediatric cardiology are directly responsible | 0 |
kaposi 's sarcoma ( ks ) is a highly angioproliferative neoplasm etiologically linked to infection with kaposi 's sarcoma - associated herpesvirus ( kshv ) , also formally known as human herpesvirus | 0 |
we defined broad consent as a process in which participants agree prospectively to have their samples , genomic data , and health information retained for use in any future research deemed appropriate | 0 |
in conventional md simulations based on classical force fields , chemical bonds are commonly never broken and the protonation state of each ionizable residue is fixed and ascribed externally by the user | 0 |
enantiomerically pure alcohols and amines constitute important synthetic building blocks and key targets in the manufacturing of a wide range of chemical products , such as agrochemicals , food additives , fragrances | 0 |
humans have domesticated animals and plants through selective breeding , producing individuals with specific traits deemed beneficial ( hazel 1950 ) . hunting and plant harvesting can have selective , evolutionary effects | 0 |
seventy - seven days before the outbreak of the second world war , the german - language neurological and psychiatric journal zentralblatt announced a new , revolutionary method in the shock therapy | 0 |
the prevalence of obesity has risen dramatically in the united states . the rates for adults have more than doubled during the past 3 decades . increases in obesity prevalence have been | 0 |
disturbances within the arachidonic acid ( aa ) cascade have been proposed as a pathophysiological mechanism in the regulation of mood and suggested to contribute to the underlying biological background for bipolar | 0 |
the title of this paper builds on the famous fable of jean de la fontaine ( 16211695 ) the oak and the reed in which he compares the two plants facing the | 0 |
the geographic distribution of very low fertility among the countries of the world , especially within europe , remains a puzzle . rapidly falling fertility in these western countries , many scholars | 0 |
escherichia coli is a common inhabitant of the gastrointestinal tract of humans and animals . usually , e. coli forms a beneficial symbiotic relationship with its host and plays important roles in | 0 |
transgenic zebrafish ( danio rerio ) tg(gfap : egfp)mi2002 and tl strain wild - type zebrafish were maintained using standard husbandry protocols . all procedures were approved by the institutional animal care | 0 |
asthma control is characterised by the management of symptoms and reduction of predicted future risk , particularly exacerbations . some asthma exacerbations can be caused by a range of risk factors and | 0 |
the three compounds lincomycin ( a natural antibiotic produced by streptomyces lincolnensis and discovered in 1961 ) , clindamycin , and pirlimycin ( two semi - synthetic derivatives of lincomycin ) comprise | 0 |
the fundamental mechanisms of modulating neural circuits in relation to specific physiological actions and behaviors in organisms are an area of current interest for basic research as well as clinical treatments . | 0 |
the development of bioinformatics has been initially driven not only by the enormous quantity of data that the biologist community was able to produce during the last decades , but also by | 0 |
if there is any litmus test for measuring the familiarity with japanese popular culture , seirogan might be a good one . looking and tasting like charcoal , as a renowned japanologist | 0 |
sight loss from glaucoma can be avoided as early treatment of the condition reduces the risk of sight loss . however , in the uk around 3000 people are newly registered with | 0 |
in some important ways , mh both replaced and replicated the social and economic networks that families , at their most basic level , constitute . nineteenth - century missionaries were slow | 0 |
we had better courageously face the fact that prejudices are themselves elements of the interpretation of the social world and even one of the mainsprings that make it tick . it makes | 0 |
this assistant could be taught the uses of the appropriate pills for the treatment of the major fevers , dysentery and high altitude headaches . besides assisting the party home , it | 0 |
dwi has been primarily applied in acute brain ischaemia , which is characterised in its early phase by cytotoxic oedema . thanks to its sensitivity in detecting hyperacute ischaemic strokes , dwi | 0 |
a healthy joint requires a fine - tuned balance between molecular signals regulating homeostasis , damage , restoration , and remodelling . this balance is determined both at the level of single | 0 |
in his inaugural speech dr robert wah , president of the american medical association ( ama ) , named star trek 's iconic physician leonard bones ' mccoy as his favourite fictional | 0 |
since the introduction of the concept or sublethally injured or viable but nonculturable ( vbnc ) cells by byrd and colwell in the 1980 's , there is increasing evidence for the | 0 |
linagliptin ( tradjenta , boehringer ingelheim , ridgefield , ct , usa ) is a newly approved medication for the treatment of type 2 diabetes mellitus.1 this agent is a potent inhibitor | 0 |
asthma is an enormous public health issue with 8.5% of people in the us diagnosed with asthma . asthma disproportionately impacts the young . according to the 2011 national health interview survey | 0 |
patients with acute cholangitis are at risk for developing severe infection that can be fatal unless appropriate medical care is provided at an early stage . advances in antibiotic therapy and acute | 0 |
coltheart , langdon , and mckay ( 2007 ) extended a two - factor explanation of capgras ' delusion to somatoparaphrenic delusions and from there to paranoid delusions in schizophrenia . the | 0 |
in highly developed countries , in order to enhance the efficiency of health care systems , the search for better practices and new organizational models is an issue . because of economic | 0 |
serotonin ( 5-ht ) , also known as 5-hydroxytryptamine or 3-(2-aminoetil)-1h - indol-5-ol , is a monoamine containing two nitrogen molecules : the first nitrogen is basic and embedded within the indol-5-ol | 0 |
alternative splicing is the process by which splice sites in precursor messenger rnas ( pre - mrnas ) are differentially selected and paired to produce multiple mature mrnas and protein isoforms with | 0 |
clinicians should be made aware not only of the importance of identifying patients with dhs but also of the relevance of a correct diagnosis that may exclude any confounding factors from other | 0 |
thp-1 cells were obtained from the german collection of microorganisms and cell cultures ( dsmz ) and cultured overnight at a cell density of 0.3 10/ml at 37c and 5% co2 in | 0 |
cell nuclei in two - dimensional ( 2d ) pathology images can yield quantitative information about the presence or absence of disease processes and also help evaluate disease progress . detecting and | 0 |
the human cerebral cortex is generally considered the most complex structure of the human body . the cortical expansion and the enlarged surface area following the highly organized folding into gyri and | 0 |
wiskott - aldrich syndrome ( was ) is an x - linked primary immunodeficiency disease resulting from mutations within the was gene that result in the loss of was protein ( wasp | 0 |
cdnas containing the sequence of human wt - ftl and human mutant ftl498499instc were introduced into the pet-28a(+ ) expression vector ( novagen , emd chemicals inc . ) . the cdnas | 0 |
chronic kidney disease is defined as kidney damage , as assessed by biopsy or markers of kidney damage , for 3 months with or without changes in glomerular filtration rate , or | 0 |
integration of functional magnetic resonance imaging ( fmri ) with electroencephalography ( eeg ) has offered the possibility of understanding new insights into neuroscientific studies because of the higher temporal and spatial | 0 |
this was surprising because he had had no interest in such materials up to that point in his life . he also found himself attracted to his 12-year - old stepdaughter , | 0 |
ovarian cancer is the most lethal and second most common gynecologic malignancy in the united states , with an estimated 21,980 new cases and 14,270 deaths expected in 2014 . first progression | 0 |
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