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the basic helix - loop - helix ( bhlh ) family of transcriptional regulators are key players in a wide array of developmental processes in metazoans , including neurogenesis , myogenesis , | 0 |
it is well - known that crystalline materials obtain their fundamental physical properties from the molecular arrangement within the solid , and altering the placement and/or interactions between these molecules can , | 0 |
many electronic properties of molecules and materials are determined by and understood through the energetics of the valence electrons , which are often probed experimentally using photoemission spectroscopy ( pes ) . | 0 |
aida v4 ( accessible freely at http://www.2aida.org ) is a downloadable program that permits the interactive simulation of plasma insulin and blood glucose ( bg ) profiles for teaching / demonstration / | 0 |
the online version of this article ( doi:10.1186/s13321 - 015 - 0089-z ) contains supplementary material , which is available to authorized users . recent work has demonstrated the power of network | 0 |
the introduction of prostate - specific antigen ( psa ) screening over the last two decades has resulted in stage migration of prostate cancer . radical prostatectomy ( rp ) for organ | 0 |
the growing use of high - throughput screening ( hts ) as a discovery tool in academic translational centers has resulted in the pursuit of assay artifacts , promiscuous bioactive compounds , | 0 |
two proven vector control strategies are currently advocated to reduce transmission of malarial disease in africa , namely indoor residual spraying ( irs ) [ 1 - 5 ] and insecticide - | 0 |
imbalances in proinflammatory and anti - inflammatory immunomodulatory pathways can promote autoimmune responses that manifest as chronic inflammatory conditions . diarthrodial joints ( those with cartilage - capped surfaces , an intervening | 0 |
the european horse meat scandal of 2013 , in which undeclared horse meat was found in a number of supermarket beef products , highlights the need for testing methods capable of detecting | 0 |
malaria , a major tropical disease for which no long - term sustainable treatment is available , continues to affect large parts of the world . according to the latest world malaria | 0 |
all animal procedures were performed in accordance with recommendations in the arvo statement for the use of animals in ophthalmic and vision research , in the guide for the care and use | 0 |
rna molecules lacking 5 and 3 ends and shaped as covalently closed circular rnas ( circrnas ) were described decades ago in a variety of model systems , but they were considered | 0 |
among striking developments in history writing towards the end of the twentieth century were the moves to the spatial and the visual in the reconstruction of historical consciousness . global history , | 0 |
natural product ( np ) research is a demanding science , requiring an in - depth knowledge of many aspects of organic , analytical , and biological chemistry , including separation science | 0 |
bacterial infections as well as the emergence and spread of antibiotic resistance in human pathogens are serious public health problems in hospital and community settings across the globe . new strategies to | 0 |
the basic concept of this technique is maintaining phase information into the final image , discarding phase artefacts and keeping just the local phase of interest . sensitivity to susceptibility effects increases | 0 |
at the 2011 annual business meeting of the canadian geriatrics society ( cgs ) , an ad hoc work group ( wg ) was struck and asked to submit a report at | 0 |
in computational geometry , many fundamental properties of finite point sets do not depend on the actual coordinates of each point in real space , but rather on the relative position of | 0 |
non - alcoholic fatty liver disease ( nafld ) is now regarded as the most common liver condition in the developed world , affecting up 30% of the population . it is | 0 |
5-ht3a receptor constructs and transfection of cdnas cdnas encoding human wild - type and mutant 5-ht3a receptor subunits were cloned into pgw1 ( 17 ) . point mutations were introduced using standard | 0 |
over the last few decades , a dramatic worldwide increase in infection rates by multidrug - resistant ( mdr ) pathogens has occurred , which is acknowledged as a public health crisis | 0 |
prostate cancer is the most common cancer in men and the second - leading cause of cancer death in men , with 241,740 new diagnoses and 28,170 deaths projected in the us | 0 |
there are three principal reasons to develop methods for the asymmetric synthesis of chiral palladacycles , an area in which many examples are metallocene - based planar chiral complexes . first is | 0 |
fifty years ago , experiments have demonstrated that perinatal asphyxia could induce brain injury in primates . since then , different patterns of brain injury have been established , which were dependent | 0 |
an -transaminase catalyzes the deamination of a primary amine ( amine donor ) and the concomitant amination of a ketone or aldehyde ( amine acceptor ) , which results in a reaction | 0 |
mid october 2009 general practitioner sandra bijl published an article in the dutch doctors journal medisch contact . she described one of the many dilemmas she faced since the introduction of marketized | 0 |
embryonic development relies upon the precise control of genetic programs to create complex tissues and organs . mutagenesis screens and the sequencing of multiple genomes have revealed an extensive list of patterning | 0 |
for the first half of the twentieth century the clandestine abortion industry seems to have been tacitly accepted by south african law enforcement officials . generally abortionists , medical and untrained alike | 0 |
unless specified , all the reactions were done in oven - dried or flame - dried glassware in an atmosphere of dry argon gas using standard schlenk techniques . the anhydrous solvents | 0 |
ribonucleotide reductases ( rnrs ) perform an essential function in all organisms , catalyzing the conversion of ribonucleotides into deoxynucleotides and providing the monomeric precursors required for dna synthesis and repair ( | 0 |
hundreds of genes have been implicated in alzheimer 's disease , many of which can be grouped into discrete signalling networks and pathways relevant to the various subpathologies , risk factors , | 0 |
since it first appeared as a clinical syndrome in central africa in the late 1970s , ebola hemorrhagic fever , now termed ebola virus disease , has intrigued infectious disease physicians , | 0 |
the combined dynamic derivative , also called diamond- ( ) dynamic derivative ( ) , was introduced as a linear convex combination of the well - known delta and nabla dynamic derivatives | 0 |
coronary artery disease ( cad ) is the leading cause of death in western countries [ 1 , 2 ] . multi detector computed tomography ( mdct ) , a non - | 0 |
parental drug misuse and its effects on children and families are policy priorities in the uk and elsewhere ( flavin & paltrow , 2010 ; hm government , 2010 ) . polydrug | 0 |
subarachnoid haemorrhage ( sah ) is caused by aneurysmal rupture in 7085% of patients [ 1 , 2 ] . in a systematic review , intraarterial digital subtraction angiography ( ia - | 0 |
sodium - ion batteries ( nibs ) are of great interest as a complementary technology to lithium - ion batteries in applications such as grid - storage , where cost and sustainability | 0 |
alzheimer 's disease ( ad ) is the most common form of dementia with a progressive course . ad pathology evidences neuronal damage in specific vulnerable brain regions and circuits involved in | 0 |
patients with retinal degeneration ( n = 5 ) and subjects with healthy vision ( n = 5 ) participated in this study ( table ) . all subjects had complete clinical | 0 |
in accordance with the recent increases in human life expectancy and income , the medicalhealthcare paradigm is gradually expanding to include post - treatment , prevention , and health management . it | 0 |
this report describes the design , implementation , and feasibility of the interstitial cystitis : elucidation of psychophysiologic and autonomic characteristics ( icepac ) study . interstitial cystitis / bladder pain syndrome | 0 |
this review was based on a systematic comprehensive search of six databases : ovid medline ( 1950 to october week 4 , 2010 ) ; pubmed ( january 1 , 2008 , | 0 |
although fish farming in iraq started in 1955 with a small pond in al - zaafaraniya , south of baghdad city , an advance was achieved in fish farming industry in iraq | 0 |
malaria is an infectious disease caused by parasites of the genus plasmodium and is a world health crisis of paramount urgency . malaria was responsible for over 200 million cases and 1 | 0 |
in this article , we describe a new computational tool to determine nearly optimal folding pathways between two given secondary structures of an rna sequence . our tool , rnatabupath , and | 0 |
rheumatoid arthritis ( ra ) is a chronic , autoimmune , systemic , inflammatory disease mainly affecting the joints characterized by pain , swelling , and stiffness , resulting in progressive joint | 0 |
conformer generation has been a topic of considerable interest to the modeling community for a number of years , and a large number of methods for conformer generation have been presented . | 0 |
the lack of hepatic g6pase was obtained by a specific deletion of g6pc exon 3 in the liver using a cre - lox strategy in mice , which was recently described by | 0 |
the human brain changes itself in response to different types of experience through the reorganisation of its neuronal connections . it is suggested that it involves firstly a short - term modulation | 0 |
chronic myelogenous leukemia ( cml ) represents about 1520% of all cases of adult leukemia in western populations . cml is a clonal myeloproliferative disease characterized by the presence in > 95% | 0 |
interacting with other human beings is a basic element of daily life , yet not a trivial challenge . many joint actions between adults are highly sophisticated , but are performed with | 0 |
unlike the more stereotypical development of the body s main blood vessels , the formation of the capillary networks responsible for tissue perfusion is an adaptive process primarily governed by the metabolic | 0 |
mobile health ( mhealth ) is a promising means of improving adherence to medication and clinic appointments thereby potentially improving clinical outcomes . mobile technology allows health care providers to communicate remotely | 0 |
characteristic features of atopic asthma are circulating specific ige antibodies , positive skin tests to common allergens , and infiltration of the bronchial mucosa with eosinophils and th2 cells . the resulting | 0 |
the study group consisted of 50 children born very preterm ( i.e. , gestational age 30 weeks , established by weeks and days after the mother s last menstrual period ) , | 0 |
significant changes in response to environmental conditions are expected to take place through the proteins situated within these membranes . membrane protein - associated changes may occur in the form of abundance | 0 |
as a consequence of the availability of whole - genome expression methodologies , regulation of gene expression is at the core of current post - genomic studies . once a set of | 0 |
the fact that exercise and physical activity have positive effects on health is well known . most of the research on exercise - induced changes carried out during the past years has | 0 |
information for this review article was derived from the extensive one health community records of the ohc and the ohi autonomous pro bono team , one health web searches conducted in the | 0 |
alzheimer s disease ( ad ) is a progressive neurodegenerative disorder starting with mild memory loss and manifesting in severe cognitive decline . neuropathologically , the disease is characterized by an extensive | 0 |
cobalamins ( figure 1 ) consist of a six - coordinate low - spin co(iii ) ion that is ligated equatorially by the four nitrogens of a tetrapyrrole macrocycle , known as | 0 |
the pursuit for a global and self - consistent conceptual , mechanistic , and theoretical framework within which to discuss the denaturing properties and behaviors of cosolvents such as urea and guanidinium | 0 |
according to the world allergy organisation about 1.9%4.9% of children suffer from cow 's milk allergy , with the prevalence in adults much lower ; less than 0.5% . it is known | 0 |
diabetic retinopathy ( dr ) is a one of the most common microvascular complications of diabetes . in 2012 , there are more than 371 million people suffering from diabetes , and | 0 |
this study regards itself as a supplement to the common melancholy of failed expectations , contrary effects , unfulfilled promises and the generally deplorable state of affairs lamented in much of the | 0 |
the majority of the protein structures deposited in the protein data bank are determined either by x - ray crystallography or solution - state nuclear magnetic resonance spectroscopy ( nmr ) . | 0 |
bovine eyes ( from 3-year - old animals ) were obtained from a local slaughterhouse within 3 hours of death . the eye globe was dissected from its anterior aspect , the | 0 |
the whole school , whole community , whole child ( wscc ) model ( figure 1 ) , developed by ascd ( formerly the association for supervision and curriculum development ) and | 0 |
radical chemistry has always taken a backseat to ionic chemistry . in the basic undergraduate curriculum of organic synthesis , the aldol reaction , grignard addition , and pericyclic transformations like the | 0 |
numerical investigations of cosmological spacetimes can be categorized into two broad classes of calculations , distinguished by their computational ( or even philosophical ) goals : 1 ) geometrical and mathematical principles | 0 |
percutaneous coronary intervention ( pci ) is a minimally invasive procedure for treating patients with advanced coronary artery disease . with this technique , a catheter system is introduced into patients circulation | 0 |
the principal types of cells present in the blood are red blood cells ( rbc ) , wbcs , and platelets . the percentage of wbc subtypes observed in human blood normally | 0 |
the main purpose of restorative dentistry is to restore and maintain tooth health by an adequate restorative treatment in order to protect and re - establish pulp function . pulp plays an | 0 |
due to the increasing number of multilinguals in modern society , the incidence of language impairments induced by brain lesions ( aphasia ) in this population is growing rapidly [ 1 , | 0 |
sponges play an important role in the benthic - pelagic coupling on coral reefs ( lesser 2006 ) . the sponge community sequesters and processes organic matter and as such conserve energy | 0 |
-adrenoceptor ligands comprise one of the most commonly used classes of drugs in clinical practice . -agonists have been used since the 1940s for their beneficial effects in respiratory disease and -antagonists | 0 |
evidence and awareness of climate change has led to an increasing need to adapt our use of land and other resources to limit risks and vulnerabilities that originate from global change ( | 0 |
the online version of this article ( doi:10.1007/s10393 - 010 - 0324-z ) contains supplementary material , which is available to authorized users . each new introduction of the highly pathogenic avian | 0 |
according to the international diabetes federation in 2013 , 328 million people are currently diagnosed with diabetes and there is a projected rise of 55% to 592 million people in the world | 0 |
the level of the genetic diversity is pivotal for world food security and survival of human civilization on earth . historically , humans exploited plant species for their livelihoods that resulted in | 0 |
we identified key actors by applying a snowball method starting with key actors in our own networks . because the netherlands is a relatively small country , this was a feasible method | 0 |
the university of british columbia clinical research ethics board ( certificate nos . h07 - 01707 and h03 - 70046 ) approved the collection of blood , and informed consent was received | 0 |
autism spectrum disorder ( asd ) is a highly heterogeneous disorder , diagnosed on the basis of behavioral criteria . from the neurobiological perspective , asd can be considered an umbrella term | 0 |
neurosurgery is characterized by the delicate balance between surgical success and potential for devastating side effects . thanks to multiple technological improvements , the morbidity of neurosurgical interventions has substantially decreased over | 0 |
as a result of a massive scale - up in malaria control programs by the who as part of the millennium development goals , the number of malaria deaths decreased worldwide by | 0 |
the fungal kingdom encompasses an enormous diversity of taxa with varied ecological niches , life - cycle strategies , and morphologies . of the 1.5 million species estimated to belong to this | 0 |
a plausible prebiotic synthesis of the canonical nucleotides has long been a major goal in origins of life research . the oligomerization of hydrogen cyanide one of the major products of spark | 0 |
a survey of more than 500 total syntheses shows that lithium diisopropylamide ( lda ) is the most frequently used reagent in organic synthesis . it is this prominence that piqued our | 0 |
all rabbits were treated in accordance with the association for research in vision and ophthalmology statement on the use of animals in ophthalmic and vision research , and the experimental protocol was | 0 |
voltage - dependent ion channels underlie the electrical signaling that allows for neurotransmission within neurons , and allow for various modes of ca influx critical to coupling this electrical activity to diverse | 0 |
frequent episodic and chronic childhood tension - type headache ( tth ) is a prevalent and debilitating situation for the child and family . after clarifying the diagnosis in an interdisciplinary setting | 0 |
over the past decade , dementia with lewy bodies ( dlbs ) has arguably become the second most common form of neurodegenerative dementia behind alzheimer 's disease ( ad ) . in | 0 |
trypanosoma brucei , trypanosoma cruzi and leishmania major are unicellular protozoa of considerable medical importance since they are the etiologic agents of sleeping sickness ( african trypanosomiasis ) , chagas disease ( | 0 |
cd47 ( originally named integrin - associated protein ( iap ) ) is a cell surface protein of the immunoglobulin ( ig ) superfamily , which is heavily glycosylated and expressed by | 0 |
mesenchymal stem cells ( mscs ) , also referred to as multipotent mesenchymal stromal cells , have been a focus of recent research , partially because they are an extraordinary model for | 0 |
accurate and automatic assessment of retinal images has been considered as a powerful tool for the diagnosis of retinal disorders such as diabetic retinopathy , hypertension , and arteriosclerosis . blood vessels | 0 |
the hydrated excess proton is in fact a unit of net positive charge due to a missing electron that can be passed between and among biomolecules in a seemingly simple dance of | 0 |
leishmaniases are a set of vector - borne diseases caused by a flagellate protozoan transmitted by the bite of an insect vector , the phlebotomine sandfly . this group of diseases affects | 0 |
infectious diseases are a major reason for the health disparity between rich and poor countries ( stiglitz and jayadev , 2010 ) . they kill 14 million people worldwide every year , | 0 |
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