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spadeMIA
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charcot marie tooth disease ( cmt ) is a clinically and genetically heterogeneous group of sensorimotor peripheral neuropathies and represents the most frequent inherited disorder(s ) affecting the nervous system . in this study , we provide preclinical , proof of principle data demonstrating efficacy in a mouse model ...
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approximately 40 million people are infected with the human immunodeficiency virus ( hiv ) worldwide ( unaids 2006 ) . infections by this lentivirus from the family retroviridae are characterized by a long asymptomatic period after host immune defenses control the initial infection . during this subsequent chronic phas...
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this study was approved by the institutional review board of the duke university health system , and all subjects participated with full informed consent . a group of 14 ophthalmic surgeons - in - training were recruited from duke university ophthalmology residents . the subjects were randomized into two groups balance...
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determining and characterizing past exposures to chemicals and physical agents is a vexing but essential challenge in industrial hygiene , pathology , occupational medicine and epidemiologic research . in particular , cumulative retrospective exposure assessment ( rea ) of asbestos has allowed dose response characteriz...
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evidence is growing in support of a role for infections in the aetiology of childhood leukaemia , particularly for the most common subtype , acute lymphoblastic leukaemia ( all ) . two infection - related hypotheses have gained popularity and are currently supported by substantial , yet inconsistent , epidemiologic fin...
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thirty years have passed after discovering human immunodeficiency virus ( hiv ) , the etiological agent of the acquired immunodeficiency syndrome ( aids ) [ 14 ] . two types of hiv are known : the most common hiv-1 , which is responsible to the worldwide aids epidemic , and the immunologically distinct hiv-2 , which is...
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functional residual capacity , frc , is the lung volume at the end of a relaxed expiration to atmospheric pressure . the frc is affected by lung diseases and thus is a central measure for diagnosis , treatment and monitoring in anesthesia and intensive care . the calculation of frc from measurement of multiple breath n...
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vaccines are one of the most successful medical interventions in human history and estimated to prevent more than 2.5 million deaths every year [ 1 , 2 ] . in essence , vaccination is about convincing the immune system to treat a noninfectious artificially introduced substance as an invading pathogen and to raise an im...
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the state of non - rem sleep ( nrem ) , or slow wave sleep , is associated with a synchronized eeg pattern in which specific electrographic events take place . these events are sleep spindles and / or k complexes and high - voltage slow wave activity ( swa ) within the delta frequency band ( between 0.5 and 4.0 hz ) th...
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procedures involving animals were approved by the animal care and use committee of the schepens eye research institute . male sprague - dawley rats ( 5 weeks of age ; taconic farms , hudson , ny ) were randomly assigned to one of the following groups : control , diabetic , diabetic treated with sorbinil ( 65 mg kg day ...
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the fundamental principles of pay - for - performance include rewarding quality health care and aligning physicians financial incentives with the best interests of patients.9 although this inherent appeal to physician self - interest might be in tension with professional ideals of altruism and beneficence,1013 the prin...
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while advances in free trade and globalization increase the movement and accelerate the accumulation of invasive species ( lockwood et al . 2005 ) , it is still unclear how introduced populations can successfully establish . as elton ( 1958 ) pointed out , for every successful invasion that occurs , there are enormousl...
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to develop methods for mapping a qtl to a phylogenetic tree , we begin with several simplifying assumptions : the taxa are represented by inbred lines , the tree relating the taxa is known without error , the quantitative trait of interest is affected by a single diallelic qtl , and there are no background effects ( i....
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health services and health policy research can be based on qualitative research methods , especially when they deal with a rapid change and develop a more fully integrated theory base and research agenda . however , the field must be with the best traditions and techniques of qualitative methods and should distinguish ...
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nine male competitive cyclists participated in this study . their mean sd age , height , and body mass were 33.3 7.5 yr , 184 4 cm , and 77.3 7.0 kg , respectively . they had a maximal oxygen consumption ( vo2max ) of 4.8 0.2 lmin ( oxycon pro ; viasys healthcare , germany ) with a peak power output of 418 16 w ( proto...
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both types of diabetes mellitus can be a lead cause for blindness , kidney failure , neuropathic diseases , foot ulceration , gas gangrene in lower limbs , foot amputations , and cardiovascular insufficiency such as ischemia , stroke , etc.1 strict control of blood glucose would be the most effective approach to preven...
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efforts have been ongoing in many countries to develop integrated ecosystem - based assessments using physical chemical properties , biological abundance and diversity , and / or chemical characterisation to define the ecological quality of aquatic environments . ( 2008 ) was produced after the international meeting , ...
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readers of this review should consider that many age - related processing speed findings reported in the literature are cross - sectional in nature , including the primary findings reviewed here . this is important because there are developmental ( laasonen et al . , 2002 ; deary et al . , 2010 ) and sampling factors t...
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alzheimer s disease ( ad ) is a progressive neurodegenerative disease that is clinically characterized by impairment of cognitive and functional abilities together with behavioral symptoms . the diagnosis of probable ad has classically been based on clinical criteria , such as those published in 1984 by the national in...
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bromodomain modules selectively recognize acetylated lysine ( kac ) containing sequences , a post - translational modification that is highly abundant in histones and other nuclear proteins . interest in these so - called epigenetic reader proteins has risen as it has become clear that the interaction between the prote...
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access to automated dna sequencing technology has made possible the rapid generation and analysis of gene transcripts expressed in organisms via expressed sequence tags ( ests ) . this information has helped to identify those genes expressed in particular stages of development and in specialized tissues or organs . nov...
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the igf system plays crucial roles in biological processes such as proliferation , differentiation , invasion , tumor expansion , migration , and survival . it can be used to predict clinical outcome , , diagnosis , endocrine responsiveness , cancer progression or inhibition of cancer growth , and apoptosis . the ligan...
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impairments in attention , cognitive control , and speed of information processing have been frequently observed after traumatic brain injury ( tbi ; stuss et al . , 1989 ; spikman et al . , deficits in these processes , which are considered to involve large - scale neural interactions ( mesulam , 1998 ) , may arise in...
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prostatic acid phosphatase ( pap ) , a glycoprotein synthesized by the prostate gland , is traditionally used to diagnose prostate cancer . pap has two isoforms , secreted and transmembrane isoforms , and , more than in the prostate gland , is also extensively expressed in nonprostate tissue such as nervous tissues .. ...
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health systems based on primary health care ( phc ) distribute health care more equitably , are more cost effective and have better overall health outcomes and impact than health systems based on specialist care ( 1 ) . this is the foundation of the health for all concept of alma - ata , adopted by the world health org...
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the advent of antihypertensive therapy has substantially reduced the occurrence of cardiovascular events . however , antihypertensive therapy failed to achieve blood pressure control in all patients , with hypertension control rates remaining in general disappointingly low . blood pressure goals are not attained in som...
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superparamagnetic iron oxide nanoparticles ( nps ) , with core diameters of 315 nm , are used in a rapidly expanding number of applications in the biomedical field ; the most common include cell labeling , hyperthermia , drug delivery , and as contrast agents for magnetic resonance imaging . for these applications , th...
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gypsies and travellers are recognized as one of the most disadvantaged minority groups in the united kingdom and globally . research into the health needs of this group is an emerging field , and gypsies and travellers could justly be described as an invisible minority1 in being rarely captured in health statistics , u...
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rna interference ( rnai ) achieved by double - stranded rna ( dsrna ) mediated sequence - specific breakdown of the mrna ( fire et al , 1998 ; montgomery and fire , 1998 ; elbashir et al , 2001a ) . it is an evolutionarily conserved phenomenon initially characterized in c. elegans and drosophila , but also occurs in pl...
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the importance of early and intensive control of blood glucose levels in improving outcomes for people with type 2 diabetes mellitus ( t2 dm ) was established in the uk prospective diabetes study ( ukpds ) . despite differences in glucose levels between the intensive and standard treatment groups disappearing soon afte...
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the advent of multislice ct technology with ecg - gating along with innovations in x - ray tube and ct detector technology have resulted in revolutionary progress in cardiac imaging . ecg - gated ct angiography with 64 + slice systems has demonstrated efficacy for the diagnosis of coronary disease , cardiac morphology ...
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the aim of the present investigation was to develop an instrument to monitor any changes in maternal and neonatal health ( mnh ) care provider motivation resulting from the introduction of pilot interventions in rural , primary level facilities in ghana , burkina faso , and tanzania . the work was undertaken in the fra...
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as a medical specialty , pathology generates and interprets laboratory data on fluid and tissue specimens . the data generated and interpretations rendered must be accurate , reproducible , and presented in a clearly understandable format , as clinical decisions will be made based on this information . to manage an eve...
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flavo - diiron proteins ( fdps ) are widespread in microaerophilic and anaerobic microorganisms , including bacteria , archaea , and a few protozoan parasites . the accumulated genetic and biochemical evidence indicates that fdps are the terminal components of a reductive dioxygen ( o2 ) and / or anaerobic nitric oxide...
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details on real - time quantitative reverse transcription - pcr ( qrt - pcr ) and primers are provided with supplementary material , table s1 , and details on immunoblotting , flow cytometry , and elisa are provided in supplementary material , note 2 . the nonsilencing control ( # rhs4348 ) and the silencing microrna -...
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they are subjected to continuous operation of stressful factors caused by the exploitation of the roads . these are mainly emissions , dust from the wear of tires and the clutch disc , and the chemical substances used to maintain the roads in the winter ( abollino et al . 2002 ; conde et al . 2009 ; jiries et al . 2002...
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protein lysine methyltransferases ( pkmts , also known as histone lysine methyltransferases ( hkmts ) ) catalyze the transfer of the methyl group from the cofactor s - adenosyl - l - methionine ( sam ) to lysine residues of histone and non - histone substrates , leading to lysine mono- , di- , and / or trimethylation ....
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h bonds in complex molecules represents a most useful but also one of the most challenging transformations in organic chemistry . over the past two decades , notable advances in the area of chemical c h oxidation involving the use of oxidizing reagents , biomimetic supramolecular complexes , or transition metal catalys...
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it is essential for all living organisms to warrant accurate functioning and propagation of their genetic information . however , the genome is constantly exposed to various environmental and endogenous agents , which produce a large variety of dna lesions ( figure 1 ) [ 1 , 2 ] . environmental damage can be induced by...
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successful management of moderate - to - severe copd can be accomplished with combination therapy that delivers a concurrent dose of inhaled corticosteroid and a long - acting 2-agonist ( ics / laba ) or with tiotropium ( tio ) , an inhaled long - acting anticholinergic bronchodilator.1 both twice - daily ics / laba an...
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dna - protein interactions are involved in several biological processes like transcription , replication , dna repair , or recombination . the variety of these mechanisms involves variations of the electrostatic potential due to groove narrowing or specific hydrogen bond donors and acceptors of the dna helix that are r...
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the human stratum corneum ( sc ) is a superficial continuous membrane made of tightly stacked corneocytes parted by multilamellar lipid sheets . its deep cohesive portion is called the stratum compactum , contrasting with the loose superficial part referred to as the stratum disjunctum . such a structure undergoes a ma...
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in a number of reviews on the induction of bone formation , we have often asked how bone differentiation by induction is initiated ? or how the soluble molecular signals of the transforming growth factor- ( tgf- ) supergene family are deployed so as to initiate de novo bone formation by induction [ 13 ] ? somehow more ...
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the observation at the lhc of a higgs particle with a mass of 125 gev [ 1 , 2 ] has important implications for supersymmetric ( susy ) and , in particular , for the minimal supersymmetric standard model ( mssm ) . in this extension , the higgs sector consists of two scalar doublet fields hu and hd that lead , after ele...
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idiopathic dilated cardiomyopathy ( dcm ) is a heart muscle disorder characterized by systolic dysfunction and dilation of the left or both ventricles in the absence of any other possible cause.1 dcm can develop in people of any age or ethnicity , although it is more common in male than female persons ( occurring at a ...
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hepatitis c virus ( hcv ) infects 175,000,000 people worldwide and is a major cause of morbidity and mortality ( 1 , 2 ) . in the united states , recent advances in the development of interferon sparing , direct - acting antiviral agents ( daa ) suggest that most treated patients can be cured , but given the limited ac...
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tim catalyzes the conversion of dihydroxyacetone phosphate ( dhap ) to ( r)-glyceraldehyde 3-phosphate ( gap ) , by proton transfer reactions at carbon , through enzyme - bound cis - enediolate reaction intermediates ( scheme 1 ) . classic studies by knowles and co - workers focused on determination of the catalytic ro...
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the extent to which computerized provider order entry ( cpoe ) systems significantly hinder or assist clinical work efficiency has been a subject of debate and investigation for over 20 years . yet the evidence base to address this issue remains sparse.13 zheng and colleagues4 recently drew attention to the poor and in...
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over the past several decades people have been constantly exposed to electric ( e ) and magnetic ( h ) fields from both industrial and domestic uses . the emfs are produced not only for technological applications ( e.g. , power lines mobile phones ) , but they are now widely used also in medicine for diagnostic ( e.g. ...
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in recent years , nanoparticles have been used increasingly for biomedical applications , including drug or gene delivery , imaging , sensing , or photothermal therapy . in particular , gold nanoparticles ( nps ) have been suggested as highly useful sensitizing agents in phototherapy due to their unique size and shape ...
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the ability to treat bacterial infection is critical to modern medicine , from abdominal surgery to transplants to cancer management . without antibiotics , these procedures would be unthinkable owing to the infection risk . yet this ability to beat infection has existed for only a brief fraction of human history , beg...
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the chemistry of heavier carbene analogues has attracted the attention of both experimentally and theoretically oriented chemists over the last decades . the fundamental differences in electronic ground states , reactivities , and structures between carbenes and their heavier counterparts are certainly a major reason f...
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it integrates signals from cortical areas and subserves important functions like motor control ( tecuapetla et al . , 2014 , kravitz et al . , 2010 ) and reinforcement / punishment coding ( kravitz et al . , 2012 ) . striatal neurons comprise gabaergic spiny projection neurons ( spns , 95% ) and interneurons ( 5% ) . s...
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they cause significant morbidity through a compression of regional structures and an inappropriate expression of pituitary hormones that disturb the multiple hypothalamic - pituitary - target organ axis systems . pituitary adenomas are clinically classified as functional ( 70% ; such as acromegaly and prolactinoma ) an...
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cooperative catalysis between thioureas and brnsted acids , whereby the enhanced catalytic activity of the thiourea acts as an acid amplifier , has successfully been applied to asymmetric catalysis , and more recently , reports have emerged from the schmidt group applying this type of synergistic catalysis to glycosyla...
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four cohorts contributed to the discovery meta - analysis through the contribution of phenotypic and gwas data . these included the framingham heart study ( n = 5,759 ) , precocious coronary artery disease ( procardis ) ( n = 3,259 ) , the fenland study ( n = 1,372 ) , and the diabetes genetics initiative ( dgi ) ( n =...
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protein protein interactions ( ppis ) play a critical role in many biological processes and in a broad spectrum of human diseases , including cancer , and small - molecule modulators of ppis are highly desired to serve as chemical tools and potential therapeutics . despite these needs , identification of small - molecu...
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there has been a dramatic increase in the proportion of babies with congenital heart disease ( chd ) surviving to adulthood . advances in pediatric surgery and pediatric cardiology are directly responsible for this favorable outcome.1 over 90% of children born with chd in the modern era are now expected to survive to a...
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kaposi 's sarcoma ( ks ) is a highly angioproliferative neoplasm etiologically linked to infection with kaposi 's sarcoma - associated herpesvirus ( kshv ) , also formally known as human herpesvirus 8 ( hhv-8 ) [ 1 , 2 ] . four epidemiological forms of ks have been described and distinguished based on age , sex , geogr...
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we defined broad consent as a process in which participants agree prospectively to have their samples , genomic data , and health information retained for use in any future research deemed appropriate by a biobank and / or relevant oversight bodies . studies of broad consent may use an opt - in or an opt - out model . ...
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in conventional md simulations based on classical force fields , chemical bonds are commonly never broken and the protonation state of each ionizable residue is fixed and ascribed externally by the user . this is a considerable limitation when trying to study ph - dependent biological processes . these include , to nam...
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enantiomerically pure alcohols and amines constitute important synthetic building blocks and key targets in the manufacturing of a wide range of chemical products , such as agrochemicals , food additives , fragrances , and pharmaceuticals . consequently , significant efforts have been dedicated to the enantioselective ...
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humans have domesticated animals and plants through selective breeding , producing individuals with specific traits deemed beneficial ( hazel 1950 ) . hunting and plant harvesting can have selective , evolutionary effects on wildlife behavior and wildlife and plant morphology ( skogland 1989 ; mcgraw 2001 ; harris et a...
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seventy - seven days before the outbreak of the second world war , the german - language neurological and psychiatric journal zentralblatt announced a new , revolutionary method in the shock therapy of schizophrenia coming from rome. a method , as well as suitable apparatus , had apparently been found which superseded ...
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the prevalence of obesity has risen dramatically in the united states . the rates for adults have more than doubled during the past 3 decades . increases in obesity prevalence have been marked across all gender , race , and socioeconomic groups . because of a relatively high prevalence , a rapidly increasing trend , an...
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disturbances within the arachidonic acid ( aa ) cascade have been proposed as a pathophysiological mechanism in the regulation of mood and suggested to contribute to the underlying biological background for bipolar disorder ( bazinet , 2010 ) . this is corroborated by preclinical evidence pointing to the arachidonic ca...
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the title of this paper builds on the famous fable of jean de la fontaine ( 16211695 ) the oak and the reed in which he compares the two plants facing the natural elements ( table 2 ) . the moral of the fable is that the oak remains immovable while the reed bends into the wind , but when the wind becomes stronger , the...
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the geographic distribution of very low fertility among the countries of the world , especially within europe , remains a puzzle . rapidly falling fertility in these western countries , many scholars argued , could be explained by the massive entry of women into the extra - domestic labor force . others , doubting that...
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escherichia coli is a common inhabitant of the gastrointestinal tract of humans and animals . usually , e. coli forms a beneficial symbiotic relationship with its host and plays important roles in promoting the stability of the luminal microbial flora and in maintaining normal intestinal homeostasis . as a commensal , ...
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transgenic zebrafish ( danio rerio ) tg(gfap : egfp)mi2002 and tl strain wild - type zebrafish were maintained using standard husbandry protocols . all procedures were approved by the institutional animal care and use committee ( iacuc ) at the university of michigan and abided by the arvo statement for the use of anim...
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asthma control is characterised by the management of symptoms and reduction of predicted future risk , particularly exacerbations . some asthma exacerbations can be caused by a range of risk factors and irritants , including exercise , allergens , pollutants and occupational exposures , viral infections , medications a...
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the three compounds lincomycin ( a natural antibiotic produced by streptomyces lincolnensis and discovered in 1961 ) , clindamycin , and pirlimycin ( two semi - synthetic derivatives of lincomycin ) comprise a group of clinically important antibiotics known as lincosamides . the structure of lincomycin ( fig . 1a ) can...
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the fundamental mechanisms of modulating neural circuits in relation to specific physiological actions and behaviors in organisms are an area of current interest for basic research as well as clinical treatments . neural circuits change in activity by modulators such as serotonin ( 5-hydroxytryptamine , 5-ht ) in alter...
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the development of bioinformatics has been initially driven not only by the enormous quantity of data that the biologist community was able to produce during the last decades , but also by the necessity of finding approaches to organize and better analyze these huge datasets . although the protein structures constitute...
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if there is any litmus test for measuring the familiarity with japanese popular culture , seirogan might be a good one . looking and tasting like charcoal , as a renowned japanologist recalled , this soft , pellet - shaped , anti - diarrhoeal herbal medicine is a symbol of katei jbiyaku ( ) , a generic over - the - cou...
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sight loss from glaucoma can be avoided as early treatment of the condition reduces the risk of sight loss . however , in the uk around 3000 people are newly registered with sight impairment due to glaucoma each year . delayed detection and thus access to early treatment is the main risk factor for sight loss and may b...
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in some important ways , mh both replaced and replicated the social and economic networks that families , at their most basic level , constitute . nineteenth - century missionaries were slow to make converts of zulu - speakers and some of the earliest to come to the mission stations and undergo baptism were those who h...
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we had better courageously face the fact that prejudices are themselves elements of the interpretation of the social world and even one of the mainsprings that make it tick . it makes little sense to tell the negrophobe in the south that in terms of biological science there is no such thing as a negro race.1 we had bet...
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this assistant could be taught the uses of the appropriate pills for the treatment of the major fevers , dysentery and high altitude headaches . besides assisting the party home , it would slowly diminish the deep - rooted superstitions that exist in the home villages, wrote new zealand mountaineer norman hardie in his...
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dwi has been primarily applied in acute brain ischaemia , which is characterised in its early phase by cytotoxic oedema . thanks to its sensitivity in detecting hyperacute ischaemic strokes , dwi has gained a primary role in routine brain mr protocols when dealing with acute neurological syndromes . the frequent utilis...
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a healthy joint requires a fine - tuned balance between molecular signals regulating homeostasis , damage , restoration , and remodelling . this balance is determined both at the level of single cells and the whole tissue architecture , and it also involves interactions among different tissues such as cartilage , bone ...
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in his inaugural speech dr robert wah , president of the american medical association ( ama ) , named star trek 's iconic physician leonard bones ' mccoy as his favourite fictional character . in his view , mccoy embodied the qualities of an exceptional leader . he was willing to collaborate to solve problems and to qu...
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since the introduction of the concept or sublethally injured or viable but nonculturable ( vbnc ) cells by byrd and colwell in the 1980 's , there is increasing evidence for the existence of such a state in microbes , particularly in the aquatic environment that elicits a myriad of interrelated sub - lethal microbial s...
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linagliptin ( tradjenta , boehringer ingelheim , ridgefield , ct , usa ) is a newly approved medication for the treatment of type 2 diabetes mellitus.1 this agent is a potent inhibitor of the serine protease enzyme , dipeptidyl peptidase-4 ( dpp-4 ) , which is responsible for rapid degradation of two incretin hormones ...
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asthma is an enormous public health issue with 8.5% of people in the us diagnosed with asthma . asthma disproportionately impacts the young . according to the 2011 national health interview survey , > 10 million children under age 18 years in the us or 14% have been diagnosed with asthma in their lifetime . this public...
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patients with acute cholangitis are at risk for developing severe infection that can be fatal unless appropriate medical care is provided at an early stage . advances in antibiotic therapy and acute care as well as a wide diffusion of expertise in biliary endoscopy have resulted in reduction of morbidity and mortality ...
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coltheart , langdon , and mckay ( 2007 ) extended a two - factor explanation of capgras ' delusion to somatoparaphrenic delusions and from there to paranoid delusions in schizophrenia . the authors argued that abnormal experiences or data give rise to delusional hypotheses which are not rejected because of damage to a ...
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in highly developed countries , in order to enhance the efficiency of health care systems , the search for better practices and new organizational models is an issue . because of economic pressures and a succession of failed attempts to improve services coordination , the concept of integrated service networks has rece...
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serotonin ( 5-ht ) , also known as 5-hydroxytryptamine or 3-(2-aminoetil)-1h - indol-5-ol , is a monoamine containing two nitrogen molecules : the first nitrogen is basic and embedded within the indol-5-ol ; the second , within 2-aminoethyl , is located at the terminus of the aliphatic chain . 5-ht is generated from tr...
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alternative splicing is the process by which splice sites in precursor messenger rnas ( pre - mrnas ) are differentially selected and paired to produce multiple mature mrnas and protein isoforms with distinct structural and functional properties . the first example of alternative splicing was discovered almost 30 years...
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clinicians should be made aware not only of the importance of identifying patients with dhs but also of the relevance of a correct diagnosis that may exclude any confounding factors from other oro - facial pain conditions prior to the successful management of the condition . one of the difficulties , facing the clinici...
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thp-1 cells were obtained from the german collection of microorganisms and cell cultures ( dsmz ) and cultured overnight at a cell density of 0.3 10 / ml at 37c and 5% co2 in roswell park memorial institute 1640 medium with glutamax ( invitrogen ) , 10% fetal bovine serum , and 50 m -mercaptoethanol . five nanomolar hu...
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cell nuclei in two - dimensional ( 2d ) pathology images can yield quantitative information about the presence or absence of disease processes and also help evaluate disease progress . detecting and segmenting nuclei correctly with minimum human effort is important for cell nuclei analysis . jung and kim showed that im...
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the human cerebral cortex is generally considered the most complex structure of the human body . the cortical expansion and the enlarged surface area following the highly organized folding into gyri and sulci ( cf . sun and hevner , 2014 ) , enable extraordinary human cognitive abilities . although the human brain is n...
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wiskott - aldrich syndrome ( was ) is an x - linked primary immunodeficiency disease resulting from mutations within the was gene that result in the loss of was protein ( wasp ) or function . subjects with was suffer from combined immunodeficiency , thrombocytopenia , and eczema and also frequently develop autoimmunity...
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cdnas containing the sequence of human wt - ftl and human mutant ftl498499instc were introduced into the pet-28a(+ ) expression vector ( novagen , emd chemicals inc . ) . the cdnas were cloned between the bamhi and xhoi sites , downstream from and in - frame with the sequence encoding an n - terminal his6 tag . to elim...
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chronic kidney disease is defined as kidney damage , as assessed by biopsy or markers of kidney damage , for 3 months with or without changes in glomerular filtration rate , or a glomerular filtration rate 60 ml / min / 1.73 m for 3 months with or without kidney damage . chronic kidney disease is an increasingly preval...
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integration of functional magnetic resonance imaging ( fmri ) with electroencephalography ( eeg ) has offered the possibility of understanding new insights into neuroscientific studies because of the higher temporal and spatial measurements of brain activity when compared with the use of each technique separately . rat...
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this was surprising because he had had no interest in such materials up to that point in his life . he also found himself attracted to his 12-year - old stepdaughter , with whom he and his wife lived . the judge gave michael the option of avoiding jail time should he pass successfully through a treatment program . mich...
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ovarian cancer is the most lethal and second most common gynecologic malignancy in the united states , with an estimated 21,980 new cases and 14,270 deaths expected in 2014 . first progression typically occurs within 18 months , and overall survival ( os ) is typically < 4 years [ 25 ] . most patients are present with ...