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Cyborg From comicbooks are characters including Deathlok and Victor "Cyborg" Stone; and manga and anime characters including 8 Man (the inspiration for "RoboCop"), Kamen Rider, Rudol von Stroheim, and "Ghost in the Shell's" Motoko Kusanagi. Playable characters such as, Kano, Jax, Cyrax, Sektor, Smoke, and Cyber Sub-Zer...
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Cyborg Sending humans to space is a dangerous task in which the implementation of various cyborg technologies could be used in the future for risk mitigation. Stephen Hawking, a renowned physicist, stated "Life on Earth is at the ever-increasing risk of being wiped out by a disaster such as sudden global warming, nucle...
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Cyborg " Experiments injecting these protective pharmaceuticals into monkeys have shown positive results in increasing radiation resistance. Although the effects of spaceflight on our body is an important issue, the advancement of propulsion technology is just as important. With our current technology, it would take us...
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Cyborg Examples of this human and technology cyborg system can be very low tech and simplistic, such as using a calculator to perform basic mathematical operations or pen and paper to make notes, or as high tech as using a personal computer or phone. According to Clark, these interactions between a person and a form of...
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Cyborg In 2013, the film won the Grand Jury Prize at the Sundance Film Festival's Focus Forward Filmmakers Competition and was awarded with US$100,000. Given the technical scope of current and future implantable sensory/telemetric devices, these devices will be greatly proliferated, and will have connections to commerc...
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Cyborg If these devices are to be proliferated within society, then the question that begs to be answered is what regulatory agency will oversee the operations, monitoring, and security of these devices? According to this case study of Three Square Market, it seems that the FDA is assuming the role in regulating and mo...
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Sofinnova is the name shared by two venture capital firms, Ventures and Partners. The name is believed to be a contraction of the French, "Société de Financement de l’Innovation" or, Innovation Venture Capital Company. Both firms trace their roots back to SA, an investment institution founded in Paris in 1972. The two ...
https://en.wikipedia.org/wiki?curid=20765003
Sofinnova The San Francisco office of Ventures was often remembered for having an original 18 ft. mosasaurus in the office of one of the Managing Partners (Mike Powell). Ventures closed their San Francisco office in 2011, and combined their Bay Area offices into a single office on Sand Hill Road in Menlo Park. Ventures...
https://en.wikipedia.org/wiki?curid=20765003
Sofinnova Sofinnova's fourth fund which raised €330M of capital made one of the largest venture firms in Europe at the time. In 2005, Partners was named “Fund of the Year” by Private Equity International and “VC Techno House of the Year 2005” by the European Venture Capital Journal (EVCJ) which described Sofinnova's fu...
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Halvor Heyerdahl Rasch (8 January 1805 – 26 August 1883) was a Norwegian zoologist and educator. He was born at Eidsberg in Østfold, Norway. Rasch studied botany and zoology at the University of Christiania (now University of Oslo). An avid hunter and sportsman, he published the book "Jagten i Norge" (1845) as well as ...
https://en.wikipedia.org/wiki?curid=20769891
NGC 35 is a spiral galaxy in the Cetus constellation.
https://en.wikipedia.org/wiki?curid=20776375
Progradation In sedimentary geology and geomorphology, the term progradation refers to the growth of a river delta farther out into the sea over time. This occurs when the mass balance of sediment into the delta is such that the volume of incoming sediment is greater than the volume of the delta that is lost through su...
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Rotational Brownian motion is the random change in the orientation of a polar molecule due to collisions with other molecules. It is an important element of theories of dielectric materials. The polarization of a dielectric material is a competition between torques due to the imposed electric field, which tend to align...
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Rotational Brownian motion The breakdown in Debye's theory in these regimes can be corrected by including inertial effects; allowing the molecules to be non-spherical; including dipole-dipole interactions between molecules; etc. These are computationally very difficult problems and rotational Brownian motion is a topic...
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Sabine Flitsch is a German organic chemist and chemical biologist who holds a personal chair in Chemical Biology at the University of Manchester School of Chemistry, where she runs an active research glycobiology research group based in the Manchester Interdisciplinary Biocentre . Flitsch was born in Münster, North Rhi...
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Sabine Flitsch Based at The Manchester Institute of Biotechnology, she is currently one of three professors of chemical biology. Additionally, Professor Flitsch is an elected member of the Royal Society of Chemistry Council of the United Kingdom and a director of the spin-out company Bio-Shape ltd. Flitsch is also curr...
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Sabine Flitsch These approaches were complemented by the use of enzymatic modifications of polysaccharides and glycoproteins to facilitate analysis, for which Prof. Flitsch’s research group has engineered tailored biocatalysts via directed evolution, and to address the biological challenge of 'sequencing' carbohydrates...
https://en.wikipedia.org/wiki?curid=61923265
Sabine Flitsch As part of a successful bid to present at the Summer Science Exhibition 2013 hosted by the Royal Society in London, Flitsch’s research was showcased along with collaborators from across the UK, through a series of hands-on activities and demonstrations. The initiative, called “The Complex Life of Sugars”...
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Sabine Flitsch Flitsch has been nominated for and awarded many prizes including the Zeneca Research Award (1996), the Glaxo Wellcome Award for Innovative Chemistry (1997) and is the recipient of a Royal Society Wolfson Merit Award (2007-2012) and a Royal Society of Chemistry Interdisciplinary Award (2014)
https://en.wikipedia.org/wiki?curid=61923265
UV detectors An Ultraviolet dectector (also known as UV detector or UV-Vis detector) is a type of non-destructive chromatography detector which measures the amount of ultraviolet or visible light absorbed by components of the mixture being eluted off the chromatography column. They are often used as detectors for high-...
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Koenigsberger ratio The is the proportion of remanent magnetization relative to induced magnetization in natural rocks. It was first described by . It is a dimensionless parameter often used in geophysical exploration to describe the magnetic characteristics of a geological body for help in interpreting magnetic anomal...
https://en.wikipedia.org/wiki?curid=61933545
Probe electrospray ionization (PESI) is an electrospray-based ambient ionization technique which is coupled with mass spectrometry for sample analysis. Unlike traditional mass spectrometry ion sources which must be maintained in a vacuum, ambient ionization techniques permit sample ionization under ambient conditions, ...
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Probe electrospray ionization During this stage, the needle is held at ground potential. The needle is then raised to be level with the mass spectrometer inlet where a high voltage of 2-3 kV is applied. Electrospray is induced at the tip of the needle, producing analyte ions which are drawn into the mass spectrometer f...
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Probe electrospray ionization In normal ESI, the sample solution is typically continuously supplied through a capillary and the charged droplets contain all sample components, with more surface-active analytes being constantly preferentially ionized. In PESI, surface-active analytes are also preferentially ionized. How...
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Probe electrospray ionization This has been demonstrated in a number of scenarios, including in the analysis of raw urine, with concentrated components such as creatinine ionization initially, followed by the appearance of previously undetected metabolites. As the PESI needle is only applicable to liquid or penetrable ...
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Probe electrospray ionization PESI-MS has proven to be particularly effective in the metabolic analysis of biological materials, having been applied to the analysis of cancerous and non-cancerous breast tissue, as well as brain and liver tissue removed from mice. Interestingly, PESI-MS has recently been applied to the ...
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Probe electrospray ionization In this work, sfPESI was also coupled with tandem mass spectrometry (MS/MS), demonstrating the capability of ion fragmentation for identification of unknown components.
https://en.wikipedia.org/wiki?curid=61952795
ACS Omega is a peer-reviewed scientific journal published since 2016 by the American Chemical Society. Its publication frequency is weekly and the current editor-in-chiefs are Krishna Ganesh and Deqing Zhang. The journal has published 4,250 peer-reviewed articles between July 2016–May 2019 and has a median time from su...
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C12H16O6 The molecular formula CHO (molar mass: 256.252 g/mol) may refer to:
https://en.wikipedia.org/wiki?curid=61975691
Gražvydas Lukinavičius (born 29 November 1978) is a Lithuanian biochemist. His scientific interest and main area of research is focused on labeling of biomolecules and visualization using super-resolution microscopy. He is co-invertor of DNA labeling technology known as Methyltransferase-Directed Transfer of Activated ...
https://en.wikipedia.org/wiki?curid=61984823
Gražvydas Lukinavičius After obtaining his PhD, he moved to École polytechnique fédérale de Lausanne for postdoctoral research where he continued on working with protein labeling methods in group of Kai Johnsson. He improved SNAP-tag protein labelling technology by developing a new biocompatible fluorophore, silicon-rh...
https://en.wikipedia.org/wiki?curid=61984823
Water distribution system A water distribution system is a part of water supply network with components that carry potable water from a centralized treatment plant or wells to water consumers in order to adequately deliver water to satisfy residential, commercial, industrial and fire fighting requirements. A definition...
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Water distribution system A service line is a small diameter pipe used to connect from a water main through a small tap to a water meter at user's location. There is a service valve (also known as curb stop) on the service line located near street curb to shut off water to the user's building. Storage facilities, or di...
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Water distribution system In general, a layout of a water distribution system can be classified as grid, ring, radial or dead end system. A grid system follows the general layout of the grid road infrastructure with water mains and branches connected in rectangles. With this topology, the water can be supplied from man...
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Water distribution system The hydraulic integrity is an ability to maintain adequate water pressure inside the pipes throughout distribution systems. It also includes the circulation and length of time that the water travels within a distribution system which has impacts on the effectiveness of the disinfectants. The w...
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Water distribution system Common microbial hazards in distribution systems come from contamination of human faecal pathogens and parasites which enter the systems through cross-connections, breaks, and water main works, and open storage tanks. Chemical hazards are those of disinfection by-products, leaching of piping m...
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Water distribution system Lead exposure can cause delays in physical and mental development in children. Long term exposure to copper may cause liver and kidney damage. High or long term exposure of cadmium may cause damage to various organs. Corrosion of iron materials causes the discoloring of the water that is shown...
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Water distribution system They can eventually leak or bust. Cement-based pipes are subjected to cement matrix and reinforced steel deterioration. All pipes are subjected to joint failures. Water quality deterioration includes scaling or tuberculation, sedimentation, and biofilm formation. Scaling is a formation of hard...
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Water distribution system Only small pits are excavated to access the existing water main. The unavailability of the water main during the rehabilitation, however, requires building a temporary water bypass system to serve as the water main in the affected area. A temporary water bypass system (known as temporary bypas...
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Chloromethcathinone may refer to:
https://en.wikipedia.org/wiki?curid=61989431
Timeline of events related to per- and polyfluoroalkyl substances This timeline of events related to per- and polyfluoroalkyl substances (PFASs) includes events related to the discovery, development, manufacture, marketing, uses, concerns, litigation, regulation, and legislation, involving the man-made PFASs, particula...
https://en.wikipedia.org/wiki?curid=61990312
Compounds of aluminium Aluminium (or aluminum) combines characteristics of pre- and post-transition metals. Since it has few available electrons for metallic bonding, like its heavier group 13 congeners, it has the characteristic physical properties of a post-transition metal, with longer-than-expected interatomic dist...
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Compounds of aluminium Aluminium also bears minor similarities to the metalloid boron in the same group; AlX compounds are valence isoelectronic to BX compounds (they have the same valence electronic structure), and both behave as Lewis acids and readily from adducts. Additionally, one of the main motifs of boron chemi...
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Compounds of aluminium In addition, although the reaction of aluminium with water at temperatures below 280 °C is of interest for the production of hydrogen, commercial application of this fact has challenges in circumventing the passivating oxide layer, which inhibits the reaction, and in storing the energy required t...
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Compounds of aluminium Oxidizing acids do not effectively attack high-purity aluminium because the oxide layer forms and protects the metal; aqua regia will nevertheless dissolve aluminium. This allows aluminium to be used to store reagents such as nitric acid, concentrated sulfuric acid, and some organic acids. The va...
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Compounds of aluminium Aluminium hydroxide forms both salts and aluminates and dissolves in acid and alkali, as well as on fusion with acidic and basic oxides: This behaviour of Al(OH) is termed amphoterism, and is characteristic of weakly basic cations that form insoluble hydroxides and whose hydrated species can also...
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Compounds of aluminium Each aluminium atom is surrounded by six fluorine atoms in a distorted octahedral arrangement, with each fluorine atom being shared between the corners of two octahedra in a structure related to but distorted from that of ReO. Such {AlF} units also exist in complex fluorides such as cryolite, NaA...
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Compounds of aluminium The aluminium trihalides form many addition compounds or complexes; their Lewis acidic nature makes them useful as catalysts for the Friedel–Crafts reactions. Aluminium trichloride has major industrial uses involving this reaction, such as in the manufacture of anthraquinones and styrene; it is a...
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Compounds of aluminium These materials are of central importance to the production of aluminium and are themselves extremely useful. Some mixed oxide phases are also very useful, such as spinel (MgAlO), Na-β-alumina (NaAlO), and tricalcium aluminate (CaAlO, an important mineral phase in Portland cement). The only stabl...
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Compounds of aluminium Although the great majority of aluminium compounds feature Al centers, compounds with lower oxidation states are known and are sometimes of significance as precursors to the Al species. AlF, AlCl, AlBr, and exist in the gaseous phase when the respective trihalide is heated with aluminium, and at ...
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Compounds of aluminium They catch fire spontaneously in air and react with water, thus necessitating precautions when handling them. They often form dimers, unlike their boron analogues, but this tendency diminishes for branched-chain alkyls (e.g. Pr, Bu, MeCCH); for example, triisobutylaluminium exists as an equilibri...
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Discovery and development of bisphosphonates Bisphosphonates are an important class of drugs originally introduced about half a century ago. They are used for the treatment of osteoporosis and other bone disorders that cause bone fragility and diseases where bone resorption is excessive. Osteoporosis is common in post-...
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Discovery and development of bisphosphonates The original bisphosphonates (first generation) were simple molecules with small groups of single atoms or alkyl chains in position R and R. They only had a rather weak inhibiting effect on bone resorption. The inclusion of an amino group marked the beginning of the second g...
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Discovery and development of bisphosphonates They operate by a slightly different mechanism in which they not only inhibit the key enzyme farnesyl pyrophosphate synthase (FPPS) of the mevalonate pathway but also geranylgeranyl pyrophosphate synthase (GGPS), an enzyme also located in the mevalonate pathway. They do not ...
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Discovery and development of bisphosphonates The bisphosphonates have an intrinsic affinity for the calcium ions (hydroxyapatite) of the bone mineral just as the endogenous pyrophosphates. The difference lies in the non-hydrolysable carbon-phosphorus bond of the bisphosphonates which prevents their metabolism and at th...
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Discovery and development of bisphosphonates The two additional groups or side chains on the carbon backbone are usually referred to as R and R. R is usually a hydroxyl group which enhances the affinity for the calcium by forming a tridentate ligand along with the phosphate groups. The compound can be made more potent ...
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Discovery and development of bisphosphonates Studies have showed that nitrogen on bisphosphonates forms hydrogen bond with threonine (Thr201) and the carbonyl part of Lysine (Lys200) on target enzyme, therefore enhancing the binding of the complex. Altering the position of nitrogen can significantly change the ability ...
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Pyrogallolarenes A pyrogallolarene (also calix[4]pyrogallolarene) is a macrocycle, or a cyclic oligomer, based on the condensation of pyrogallol (1,2,3-trihydroxybenzene) and an aldehyde. are a type of calixarene, and a subset of resorcinarenes that are substituted with a hydroxyl at the 2-position. Pyrogallolarenes, l...
https://en.wikipedia.org/wiki?curid=61999316
Junqiao Wu is a professor of materials science at the University of California, Berkeley. Wu's materials science research focuses on thermal energy. Wu's research in semiconductors has led to the discovery that electrons in vanadium dioxide conduct energy without conducting heat.
https://en.wikipedia.org/wiki?curid=62011298
Peter Ventzek (1964–) is an engineer. In 2006 he received the NOGLSTP GLBT engineer award for outstanding contributions to the semiconductor industry. Ventzek was born in Columbus, Georgia in 1964. He received B.S. in Chemical Engineering from the University of New Brunswick and his PhD in Nuclear Engineering from the ...
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Peter Ventzek In 2006, Ventzek received NOGLSTP GLBT Engineer Award, which recognizes a GLBT Engineer who has made outstanding contributions in their field. This award honors Ventzek's contributions to improvements in the semiconductor industry as well as his support of GLBT employees at Freescale. In 2013, Ventzek rec...
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Nanolattice A nanolattice is a synthetic porous material consisting of nanometer-size members which are patterned into an ordered lattice structure, like a space frame. Driven by the evolution of 3D printing techniques, nanolattices aiming to exploit beneficial material size effects through miniaturized lattice designs...
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Nanolattice The extremely small volume of their individual members thereby statistically nearly eliminates the material flaw population and the base material of nanolattices can reach mechanical strengths on the order of the theoretical strength of an ideal, perfect crystal. While such effects are typically limited to ...
https://en.wikipedia.org/wiki?curid=62013142
Strasbourg Institute of Material Physics and Chemistry The (IPCMS—) is a joint research unit between the French National Center for Scientific Research (CNRS) and the University of Strasbourg. It was founded in 1987 and is located in the district of Cronenbourg in Strasbourg, France. The IPCMS was born from a reflectio...
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Strasbourg Institute of Material Physics and Chemistry The IPCMS is then organized into five research groups around three types of materials - polymers and organic materials, metallic materials, ceramics and inorganic materials - and two topics of study: nonlinear optics and optoelectronics on one hand, surfaces and in...
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Strasbourg Institute of Material Physics and Chemistry The IPCMS is very attached to maintain strong links with the industrial laboratories carrying out research in its fields of competence. The IPCMS now employs a staff of 240 including about 80 researchers and teacher-researchers and 60 technical and administrative e...
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Betty Sullivan Betty Julia Sullivan (31 May 1902 — 25 December 1999) was an American biochemist between the 1920s and 1940s at Russell Miller Milling Company. In 1947, Sullivan began her executive career as research director and vice-president for Russell Miller until the company became part of Peavey Company in 1958. ...
https://en.wikipedia.org/wiki?curid=62018822
Betty Sullivan While at Russell Miller, Sullivan was promoted to head chemist in 1927 and research director in 1947. While researching the food chemistry of wheat and flour, Sullivan simultaneously held the position of vice-president. After Russell Miller became a part of Peavey Company in 1958, Sullivan continued her ...
https://en.wikipedia.org/wiki?curid=62018822
Microcracks in rock Microcracks in rock, also known as microfractures and cracks, are spaces in rock with the longest length of 1000 μm and the other two dimensions of 10 μm. In general, the ratio of width to length of microcracks is between 10 to 10. Due to the scale, microcracks are observed using microscope to obtai...
https://en.wikipedia.org/wiki?curid=62020761
Microcracks in rock In a thin section, the observed length and width may not necessarily be the true length and width of a microcrack in three dimensions. The aspect ratio is the ratio of width to length. It is generally10 to 10. The crack length increases with increasing maximum applied stress, resulting in a decrease...
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Microcracks in rock The evolution of microcracks has been studied through experiment. When force is applied to a rock sample, microcracks initially form randomly in space. They then become more and more localized and intense with continuous loading. This phenomenon is called the crack localization. A thoery of failure ...
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Microcracks in rock Microcrack recovery will direclty cause a decrease in permeability of rock. It can be either caused by increase in the applied stress or decrease in the effective stress. For example, microcracks perpendicular to the maximum stress direction will close. However, in nature, parts of a microcrack can ...
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Microcracks in rock Observation of thin section using microscope is to obtain the distributions of microcrack lengths, widths and aspect ratios, numbers and densities, as well as orientations. Another method is using acoustic emission to detect and monitor microcrack growth. Experimental results can help scientists dev...
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Microcracks in rock These loading modes can be achieved by the designed loading scheme. Mode I fractures are the most common microcracks in rock in natural. An acoustic emission (AE) is a high-frequency elastic wave. It is generated from microcrack formations, and is corelated to rapid microcrack growth. Acoustic emiss...
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Microcracks in rock Therefore, microcracks can be useful for assessing the stress history or fluid movement history of rock. Acoustic emission from microcrack growth may help to understand earthquakes. Microcracks can affect the thermal and transport properties of rock. Studies of microcracks in rock provide an importa...
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Microcracks in rock A depleted oil and gas reservoir that is out of energy source is one of the examples used for underground storage.
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Christian Amatore (born 9 December 1951 in Algeria) is a French chemist and a member of the French Academy of Sciences. He is an author of works in electrochemistry. Coming from a modest family (Sicilian by his father, Swedish by his mother), he spent a large part of his childhood in Algeria in several garrison towns o...
https://en.wikipedia.org/wiki?curid=62032296
C29H52 The molecular formula CH may refer to:
https://en.wikipedia.org/wiki?curid=62033048
Parascorodite (FeAsO·2HO) is a rare, secondary iron-arsenate mineral. It was discovered in 1967 using X-ray powder diffraction methods, when an unknown substance was found along with scorodite on medieval ore dumps in the Czech Republic. The holotype of parascorodite can be found in the mineralogical collection of the ...
https://en.wikipedia.org/wiki?curid=62035449
Parascorodite It is a soft mineral, falling between 1-2 on the Mohs hardness scale. Aggregates can be white to yellowish, or more rarely green-grey in color, and have a yellow-white streak. The measured density of earthy aggregates in ethyl alcohol is 3.212 g/cm. The rare green-grey variety of parascorodite aggregates ...
https://en.wikipedia.org/wiki?curid=62035449
Adriana Lita Adriana Eleni Lita is a materials scientist. She works in the Faint Photonics Group at the National Institute of Standards and Technology, where her research has included Bell test experiments and the practical implementation of quantum key distribution. She completed a Ph.D. at University of Michigan in 2...
https://en.wikipedia.org/wiki?curid=62064684
Leaded copper is a metal alloy of copper with lead. A small amount of lead makes the copper easier to machine. Alloys with a larger amount of lead are used for bearings. Brass and bronze alloys of copper may have lead added and are then also sometimes referred to as leaded copper alloys. and its alloys have been used s...
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Leaded copper Lead is a heavy metal toxin and in recent times the use of leaded copper alloys has been reduced. Signs of leaded copper use are found in the manufacture of ancient Egyptian faience. By 1500 BC leaded copper could be found across the Old World from East Asia to Africa and Europe.
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Metal–inorganic framework Metal–inorganic frameworks (MIFs) are a class of compounds consisting of metal ions or clusters coordinated to inorganic ligands to form one-, two-, or three-dimensional structures. They are a subclass of coordination polymers, with the special feature that they are often porous. They are inor...
https://en.wikipedia.org/wiki?curid=62086463
Marta Catellani is an Italian chemist known for her discovery of the eponymous Catellani reaction in 1997. She was elected to the European Academy of Sciences in 2016. Catellani earned her Ph.D. in chemistry in 1971 from the University of Parma, where, as of 2019, she is a professor and chairs the Department of Organic...
https://en.wikipedia.org/wiki?curid=62096452
Winnie Wong-Ng Winnie Kwai-Wah Wong-Ng () is a Chinese-American physical chemist. She is a research chemist at the ceramics division at the National Institute of Standards and Technology. Her research includes energy applications, crystallography, thermoelectric standards, metrology, and data, sorbent materials for sus...
https://en.wikipedia.org/wiki?curid=62096903
Winnie Wong-Ng Wong-Ng's research interest includes materials for energy applications, thermoelectric standards, metrology, and data, sorbent materials for sustainability, and high throughput combinatorial approach for novel materials discovery and property optimization for energy conversion applications. She also rese...
https://en.wikipedia.org/wiki?curid=62096903
DFDT Difluorodiphenyltrichloroethane (DFDT) is a chemical compound. Its composition is the same as that of the insecticide DDT, except that two of DDT's chlorine atoms are replaced by two fluorine atoms. was developed as an insecticide by German scientists during World War II, partly to avoid having to pay license fees...
https://en.wikipedia.org/wiki?curid=62097245
Low-FODMAP diet A low-FODMAP diet consists in the global restriction of all fermentable carbohydrates (FODMAPs), that is recommended only for a short time. A low-FODMAP diet is recommended for managing patients with irritable bowel syndrome (IBS) and can reduce digestive symptoms of IBS including bloating and flatulenc...
https://en.wikipedia.org/wiki?curid=62100056
Low-FODMAP diet Since the consumption of gluten is suppressed or reduced with a low-FODMAP diet, the improvement of the digestive symptoms with this diet may not be related to the withdrawal of the FODMAPs, but of gluten, indicating the presence of an unrecognized celiac disease, avoiding its diagnosis and correct trea...
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Low-FODMAP diet Over many years, there have been multiple observations that ingestion of certain short-chain carbohydrates, including lactose, fructose and sorbitol, fructans and galactooligosaccharides, can induce gastrointestinal discomfort similar to that of people with irritable bowel syndrome. These studies also s...
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Low-FODMAP diet This was proposed to reduce stimulation of the gut's nervous system and provide the best chance of reducing symptom generation in people with IBS (see below). At the time, there was no collective term for indigestible or slowly absorbed, short-chain carbohydrates, so the term 'FODMAP' was created to imp...
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Norcholestane Norcholestane, also known by the molecular formula CH, may refer to:may refer to:
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International Federation of Petroleum and Chemical Workers The (IFPCW) was a global union federation bringing together trade union representing workers in the chemical and oil industries. The secretariat was established in 1954 at a meeting in Paris, held on the initiative of the International Confederation of Free Tra...
https://en.wikipedia.org/wiki?curid=62120907
Prime editing is a ‘search-and-replace’ genome editing technology in molecular biology by which the genome of living organisms may be modified. The technology directly writes new genetic information into a targeted DNA site. It uses a fusion protein, consisting of a catalytically impaired Cas9 endonuclease fused to an ...
https://en.wikipedia.org/wiki?curid=62129266
Prime editing This results in a branched intermediate that contains two DNA flaps: a 3’ flap that contains the newly synthesized (edited) sequence, and a 5’ flap that contains the dispensable, unedited DNA sequence. The 5’ flap is then cleaved by structure-specific endonucleases or 5’ exonucleases. This process allows ...
https://en.wikipedia.org/wiki?curid=62129266
Prime editing Despite its increased efficacy, the edit inserted by PE2 might still be removed due to DNA mismatch repair of the edited strand. To avoid this problem during DNA heteroduplex resolution, an additional single guide RNA (sgRNA) is introduced. This sgRNA is designed to match the edited sequence introduced by...
https://en.wikipedia.org/wiki?curid=62129266
Prime editing The prime system introduces single-stranded DNA breaks instead of the double-stranded DNA breaks observed in other editing tools, such as base editors. Collectively, base editing and prime editing offer complementary strengths and weaknesses for making targeted transition mutations. Base editors offer hig...
https://en.wikipedia.org/wiki?curid=62129266
Prime editing As of 2019, prime editing looks promising for relatively small genetic alterations, but more research needs to be conducted to evaluate whether the technology is efficient in making larger alterations, such as targeted insertions and deletions. Larger genetic alterations would require a longer RT template...
https://en.wikipedia.org/wiki?curid=62129266
Prime editing 3kb, which doesn't even account for the lengthened guide RNA necessary for targeting and priming the site of interest. Images created with Biorender.
https://en.wikipedia.org/wiki?curid=62129266