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Bioartificial heart Decellularization-recellularization involves using a cadaveric heart, removing the cellular contents while maintaining the protein matrix (decellularization), and subsequently facilitating growth of appropriate cardiovascular tissue inside the remaining matrix (recellularization). Over the past year... | https://en.wikipedia.org/wiki?curid=42239426 |
Bioartificial heart The remaining ECM is composed of structural elements such as collagen, laminin, elastin and fibronectin. The ECM scaffold promotes proper cellular proliferation and differentiation, vascular development, as well as providing mechanical support for cellular growth. Because minimal DNA material remain... | https://en.wikipedia.org/wiki?curid=42239426 |
Bioartificial heart The use of decellularization and recellularization processes, has led to the production of a three dimensional matrix that promotes cellular growth; the repopulation of the matrix containing appropriate cell composition; and the bioengineering of organs demonstrating functionality (limited) and resp... | https://en.wikipedia.org/wiki?curid=42239426 |
Chibaite is a rare silicate mineral. It is a silica clathrate with formula SiO·n(CH,CH,CH,i-CH) (n = 3/17 (max)). The mineral is cubic (diploidal class, m) and the silica hosts or traps various hydrocarbon molecules, such as methane, ethane, propane and isobutane. was first described for specimens collected from Arakaw... | https://en.wikipedia.org/wiki?curid=42242866 |
Min System The is a mechanism composed of three proteins MinC, MinD, and MinE used by "E. coli" as a means of properly localizing the septum prior to cell division. Each component participates in generating a dynamic oscillation of FtsZ protein inhibition between the two bacterial poles to precisely specify the mid-zon... | https://en.wikipedia.org/wiki?curid=42243737 |
Min System The Min proteins prevent the FtsZ ring from being placed anywhere but near the mid cell and are hypothesized to be involved in a spatial regulatory mechanism that links size increases prior to cell division to FtsZ polymerization in the middle of the cell. One model of Z-ring formation permits its formation ... | https://en.wikipedia.org/wiki?curid=42243737 |
Min System Once the MinD/C complex is released, MinC becomes inactivated. This prevents MinC from deactivating FtsZ. As a consequence, this activity imparts regional specificity to Min localization. Thus, FtsZ can form only in the center, where the concentration of the inhibitor MinC is minimal. Mutations that prevent ... | https://en.wikipedia.org/wiki?curid=42243737 |
Min System Importantly, MinD and MinE can self-organize into a wide variety of patterns depending on the reaction conditions. Additional study is required to elucidate the extent of temporal and spatial signaling permissible by this biological function. These "in vitro" systems offered unprecedented access to features ... | https://en.wikipedia.org/wiki?curid=42243737 |
Journal of Inorganic Biochemistry The is a monthly peer-reviewed scientific journal covering research on the inorganic aspects of biochemistry, such as metalloenzymes and metallobiomolecules. The journal was established in 1971 as "Bioinorganic Chemistry", obtaining its current name in 1979. Since 1996, the editor-in-c... | https://en.wikipedia.org/wiki?curid=42252089 |
C20H22N2O3 The molecular formula CHNO (molar mass: 338.400 g/mol) may refer to: | https://en.wikipedia.org/wiki?curid=42257199 |
C27H39NO2 The molecular formula CHNO (molar mass: 409.604 g/mol) may refer to: | https://en.wikipedia.org/wiki?curid=42257207 |
Chemical chameleon The chemical chameleon is a redox reaction, well known from classroom demonstrations, that exploits the dramatic color changes associated with the various oxidation states of manganese. Glauber reported the first description of the production of potassium permanganate when he noted that manganese dio... | https://en.wikipedia.org/wiki?curid=42257838 |
IPhone 6 The iPhone 6 and iPhone 6 Plus are smartphones designed and marketed by Apple Inc. It is the eighth generation of the iPhone, succeeding the iPhone 5S, and was announced on September 9, 2014 and released on September 19, 2014. The iPhone 6 and iPhone 6 Plus jointly were themselves replaced as the flagship devi... | https://en.wikipedia.org/wiki?curid=42259842 |
IPhone 6 The iPhone 6 and 6 Plus have been the subject of several hardware issues, including most prominently, being susceptible to bending under hard pressure (dubbed "Bendgate"), and as a byproduct of this lack of rigidity, the touchscreen's internal hardware being susceptible to losing its connection to the phone's ... | https://en.wikipedia.org/wiki?curid=42259842 |
IPhone 6 The iPhone 5 and its immediate successors featured a display that was taller, but the same width as prior models, measuring at 4 inches diagonally. Following Apple's loss in smartphone market share to companies producing phones with larger displays, reports as early as January 2014 suggested that Apple was pre... | https://en.wikipedia.org/wiki?curid=42259842 |
IPhone 6 In China, where the iPhone 5C and 5S were the first models in the iPhone series to be released in the country on the same day as their international launch, Apple notified local wireless carriers that it would be unable to release the iPhone 6 and iPhone 6 Plus on the 19th there were "details which are not rea... | https://en.wikipedia.org/wiki?curid=42259842 |
IPhone 6 The iPhone 6 and 6 Plus were discontinued on September 7, 2016, when Apple announced the iPhone 7 and iPhone 7 Plus, and the iPhone 6 and 6 Plus' spot as the entry-level iPhone was taken by the first-generation iPhone SE. As the iPhone SE has more powerful internal hardware than the midrange iPhone 6 (largely ... | https://en.wikipedia.org/wiki?curid=42259842 |
IPhone 6 The iPhone 6 has a thickness of , while the iPhone 6 Plus is in thickness; both are thinner than the iPhone 5c and iPhone 5s, with the iPhone 6 being Apple's thinnest phone to date. The most significant changes to the iPhone 6 and iPhone 6 Plus are its displays; both branded as "Retina HD Display" and "ion-str... | https://en.wikipedia.org/wiki?curid=42259842 |
IPhone 6 Phil Schiller touted that the A8 chip would provide, in comparison to the 5s, a 25% increase in CPU performance, a 50% increase in graphics performance, and less heat output. Early hands-on reports suggested that the A8's GPU performance might indeed break away from previous generations doubling of performance... | https://en.wikipedia.org/wiki?curid=42259842 |
IPhone 6 The iPhone 6 Plus camera is nearly identical, but also includes optical image stabilization. The front-facing camera was also updated with a new sensor and f/2.2 aperture, along with support for burst and HDR modes. When first released, the iPhone 6 and iPhone 6 Plus were supplied pre-loaded with iOS 8, while ... | https://en.wikipedia.org/wiki?curid=42259842 |
IPhone 6 However, the plastic antenna strips on the rear of the phone were criticized for resulting in poor aesthetics, the display for having lower resolution and pixel density in comparison to other recent smartphones – including those with the same physical screen size as the iPhone 6, such as the HTC One, and for n... | https://en.wikipedia.org/wiki?curid=42259842 |
IPhone 6 The iPhone 6 and 6 Plus were affected by a number of notable hardware-related issues, including but not limited to concerns surrounding their rigidity (which led to incidents surrounding chassis bending, as well as degradation or outright loss of touchscreen functionality), performance issues on models with la... | https://en.wikipedia.org/wiki?curid=42259842 |
IPhone 6 On October 1, 2014, Axel Telzerow, editor-in-chief of the German magazine "Computer Bild", reported that following the posting of a video where a presenter (Unbox Therapy) was able to bend an iPhone 6 Plus, an Apple Germany representative informed the publication that it had been banned from future Apple event... | https://en.wikipedia.org/wiki?curid=42259842 |
IPhone 6 It was reported that Apple had planned to switch the affected model lines back to multi-layer cell flash, and address the performance issues on existing devices in a future iOS update. It was reported that the optical image stabilization systems on some iPhone 6 Plus models were faulty, failing to properly sta... | https://en.wikipedia.org/wiki?curid=42259842 |
IPhone 6 If the iPhone 6 home button is repaired or modified by a third party, the device will fail security checks related to Touch ID as the components have not been "re-validated" for security reasons—a process that can only be performed by an authorized Apple outlet. Failing these checks disables all features relat... | https://en.wikipedia.org/wiki?curid=42259842 |
IPhone 6 Normal use of the device can cause the logic board to flex internally, which strains the touchscreen IC connectors and leads to a degradation or outright loss of touchscreen functionality. A symptom that has been associated with this type of failure is a flickering grey bar near the top of the display. iFixit ... | https://en.wikipedia.org/wiki?curid=42259842 |
IPhone 6 An Apple Store employee interviewed by "Apple Insider" reported that six months after they first started noticing the problem, Apple had issued guidance instructing them to tell affected users that this was a hardware issue that could not be repaired and that their iPhone had to be replaced. However, some in-s... | https://en.wikipedia.org/wiki?curid=42259842 |
IPhone 6 On November 17, 2016, Apple officially acknowledged the issue and announced a paid repair program for affected iPhone 6 Plus models, stating that "some iPhone 6 Plus devices may exhibit display flickering or Multi-Touch issues after being dropped multiple times on a hard surface and then incurring further stre... | https://en.wikipedia.org/wiki?curid=42259842 |
Slug flow In fluid mechanics, slug flow in liquid–gas two-phase flow is type of flow pattern. Lighter, faster moving "continuous" fluid which contains gas bubbles - pushes along a "disperse" gas bubble. Pressure oscillations within piping can be caused by slug flow. The word slug usually refers to the heavier, slower m... | https://en.wikipedia.org/wiki?curid=42261806 |
Joseph B. Klemp Joseph Bernard Klemp is an American atmospheric scientist who collaborated in groundbreaking work advancing numerical simulation techniques and uncovering the dynamics of atmospheric convection, including supercell thunderstorms, tornadoes, squall lines, as well as mountain waves. | https://en.wikipedia.org/wiki?curid=42262656 |
Ste5 is a MAPK scaffold protein involved in the mating of yeast. The active complex is formed by interactions with the MAPK Fus3, the MAPK kinase (MAPKK) Ste7, and the MAPKK kinase Ste11. After the induction of mating by an appropriate mating pheromone (either a-factor or α –factor) and its associated proteins are recr... | https://en.wikipedia.org/wiki?curid=42263535 |
Ste5 Both this catalytically active domain as well as Ste7 are required for full Fus3 activation, which explains why Fus3 is activated by only the mating pathway, and remains inactive during other pathways which also utilize Ste7. can be localized to the cytoplasm, mating projection tip, nucleus, and plasma membrane. i... | https://en.wikipedia.org/wiki?curid=42263535 |
Superconducting computing Superconducting logic refers to a class of logic circuits or logic gates that use the unique properties of superconductors, including zero-resistance wires, ultrafast Josephson junction switches, and quantization of magnetic flux (fluxoid). is a form of cryogenic computing, as superconductive ... | https://en.wikipedia.org/wiki?curid=42266481 |
Superconducting computing This is expected to result in power consumption savings of a factor of 500 for an exascale computer. For comparison, in 2014 it was estimated that a 1 exaFLOPS computer built in CMOS logic is estimated to consume some 500 megawatts of electrical power. Superconducting logic can be an attractiv... | https://en.wikipedia.org/wiki?curid=42266481 |
Superconducting computing Josephson junction count is a measure of superconducting circuit or device complexity, similar to the transistor count used for semiconductor integrated circuits. research has been pursued by the U. S. National Security Agency since the mid-1950s. However, progress could not keep up with the i... | https://en.wikipedia.org/wiki?curid=42266481 |
Superconducting computing In 1985, the Rapid single flux quantum logic scheme, which had improved speed and energy efficiency, was developed by researchers at Moscow State University. These advances led to the United States' Hybrid Technology Multi-Threaded project, started in 1997, which sought to beat conventional se... | https://en.wikipedia.org/wiki?curid=42266481 |
Superconducting computing The Josephson junctions are critically damped, typically by addition of an appropriately sized shunt resistor, to make them switch without a hysteresis. Clocking signals are provided to logic gates by separately distributed SFQ voltage pulses. Power is provided by bias currents distributed usi... | https://en.wikipedia.org/wiki?curid=42266481 |
Superconducting computing Efficient rapid single flux quantum (ERSFQ) logic was developed to eliminate the static power losses of RSFQ by replacing bias resistors with sets of inductors and current-limiting Josephson junctions. Efficient single flux quantum (eSFQ) logic is also powered by direct current, but differs fr... | https://en.wikipedia.org/wiki?curid=42266481 |
Calcium looping (CaL), or the regenerative calcium cycle (RCC), is a second-generation carbon capture technology. It is the most developed form of carbonate looping, where a metal (M) is reversibly reacted between its carbonate form (MCO) and its oxide form (MO) to separate carbon dioxide from other gases coming from e... | https://en.wikipedia.org/wiki?curid=42268134 |
Calcium looping The forward, endothermic step is called calcination while the backward, exothermic step is carbonation. A typical Ca-looping process for post-combustion CO capture is shown in Figure 1, followed by a more detailed description. Flue gas containing CO is fed to the first vessel (the carbonator), where car... | https://en.wikipedia.org/wiki?curid=42268134 |
Calcium looping Similarly, the temperature of >850 C in the calcinator strikes a balance between increased rate of calcination at higher temperatures and reduced rate of degradation of CaO sorbent at lower temperatures. CaL is usually designed using a dual fluidised bed system to ensure sufficient contact between the g... | https://en.wikipedia.org/wiki?curid=42268134 |
Calcium looping The provision of oxygen for the combustion uses lots of electricity; other air separation processes are being developed. Indirect provision of heat to the calciner involves either: Indirect methods are generally less efficient but do not require the provision of oxygen for combustion within the calciner... | https://en.wikipedia.org/wiki?curid=42268134 |
Calcium looping In fluidised beds, the calcium oxide particles can break apart upon collision with the other particles in the fluidised bed or the vessel containing it. [REF] The problem seems to be greater in pilot plant tests than at a bench scale. Sulfation is a relatively slow reaction (several hours) compared with... | https://en.wikipedia.org/wiki?curid=42268134 |
Calcium looping The heat required for the endothermic calcination of CaCO and the heat required to raise the temperature of fresh limestone from ambient temperature, can be provided by in-situ oxy-fired combustion of fuel in the calciner. Although additional energy is required to separate O from N, the majority of the ... | https://en.wikipedia.org/wiki?curid=42268134 |
Calcium looping As seen in Figure 2, while mass after calcination remains constant, the mass change upon carbonation- the carrying capacity- reduces with a large number of cycles. In calcination, porous CaO (molar volume = ) is formed in place of CaCO (.). On the other hand, in carbonation, the CaCO formed on the surfa... | https://en.wikipedia.org/wiki?curid=42268134 |
Calcium looping An ideal sorbent would be mechanically strong, maintain its reactive surface through repeated cycles, and be reasonably inexpensive. Using thermally pre-activated particles or reactivating spent sorbents through hydration are two promising options. Thermally pre-activated particles have been found to re... | https://en.wikipedia.org/wiki?curid=42268134 |
Calcium looping Portland cement is approximately two-thirds calcium oxide by mass and its manufacture is responsible for approximately 8% of the world's CO emissions. 60% of this CO comes from the calcination of calcium carbonate as shown earlier in this article, and the other 40% from fossil fuel combustion. By replac... | https://en.wikipedia.org/wiki?curid=42268134 |
Calcium looping This can be attributed to the high availability and low cost of the CaO sorbent (derived from limestone) as compared to MEA. Also, as discussed in section 2, Ca-looping imposes a lower energy penalty than amine scrubbing, resulting in lower energy costs. The amine scrubbing process is energy intensive, ... | https://en.wikipedia.org/wiki?curid=42268134 |
Calcium looping The cost of limestone is largely driven by market forces, and is outside the control of the plant. Currently, carbonators require a Ca/C ratio of 4 for effective CO capture. However, if the Ca/C ratio or CaO deactivation is reduced (i.e. the sorbent can be made to work more efficiently), the reduction i... | https://en.wikipedia.org/wiki?curid=42268134 |
Calcium looping For example, adding Ca-looping to all coal-fired plants in the UK would generate enough waste for 33 Mtonnes/yr of cement production, whereas current cement production in the UK is only 12.5 Mtonnes/yr. Hence, if the technology is applied on a large scale, the purge rate of CaO should be optimized to mi... | https://en.wikipedia.org/wiki?curid=42268134 |
Calcium looping An IEA report concludes that to meet emission reduction goals, there should be 450 CCS projects in India and China by 2050. However, this could be politically difficult, especially with these nations’ numerous other development goals. After all, for a politician to commit money to CCS might be less adva... | https://en.wikipedia.org/wiki?curid=42268134 |
Calcium looping However, as the following calculation shows, despite integration with cement industry, waste from Ca-looping can still be a problem. From the environmental and health standpoint, Ca-looping compares favorably with amine scrubbing. Amine scrubbing is known to generate air pollutants, including amines and... | https://en.wikipedia.org/wiki?curid=42268134 |
Calcium looping In addition, crushed limestone used in calcium looping as the sorbent is a natural product, which is well distributed all over the world, non-hazardous and inexpensive. Many cement manufacturers or power plants located close to limestone sources could conceivably employ for CO capture. The waste sorbent... | https://en.wikipedia.org/wiki?curid=42268134 |
Calcium looping 5% for monoethanolamine and 9% for chilled ammonia) but also a less complex retrofitting process. Both technologies would require the plant to be retrofitted for adoption, but the calcium looping retrofitting process would result in twice the net power output of the scrubbing technology. Furthermore, th... | https://en.wikipedia.org/wiki?curid=42268134 |
Calcium looping To make Ca-looping more viable, waste must be minimized (i.e. sorbent degradation reduced) to ideally about 1/10th of current levels. | https://en.wikipedia.org/wiki?curid=42268134 |
Doctor in a cell By combining computer science and molecular biology, researchers have been able to work on a programmable biological computer that in the future may navigate within the human body, diagnosing diseases and administering treatments. This is what Professor Ehud Shapiro from the Weizmann Institute termed a... | https://en.wikipedia.org/wiki?curid=42283768 |
Doctor in a cell (2) A simplified implementation of an automaton in which the DNA input molecule is used as fuel (3) A stochastic molecular automata in which transition probabilities can be programmed by varying the concentration of “software” molecules, specifically the relative concentrations of molecules encoding co... | https://en.wikipedia.org/wiki?curid=42283768 |
Doctor in a cell Introduced into the body, this system has immense potential to accurately target specific cell types and administer the appropriate treatment, as it can perform millions of calculations at the same time and ‘think’ logically. Prof Shapiro’s team aims to make these computers perform highly complex actio... | https://en.wikipedia.org/wiki?curid=42283768 |
Doctor in a cell The device has been programmed to identify certain parameters and mount an appropriate response. The device searches for transcription factors - proteins that control the expression of genes in the cell. A malfunction of these molecules can disrupt gene expression. In cancer cells, for example, the tra... | https://en.wikipedia.org/wiki?curid=42283768 |
Doctor in a cell Yet another research goal is to operate a similar system inside human cells, which are much more complex than bacteria. | https://en.wikipedia.org/wiki?curid=42283768 |
Ligand binding assay A (LBA) is an assay, or an analytic procedure, which relies on the binding of ligand molecules to receptors, antibodies or other macromolecules. A detection method is used to determine the presence and extent of the ligand-receptor complexes formed, and this is usually determined electrochemically ... | https://en.wikipedia.org/wiki?curid=42291886 |
Ligand binding assay Historically, ligand binding assay techniques were used extensively to quantify hormone or hormone receptor concentrations in plasma or in tissue. The ligand-binding assay methodology quantified the concentration of the hormone in the test material by comparing the effects of the test sample to the... | https://en.wikipedia.org/wiki?curid=42291886 |
Ligand binding assay As a direct result of these monumental findings, researchers have continued the advancement of ligand binding assays in many facets in the fields of biology, chemistry, and the like. Ligand binding assays provide a measure of the interactions that occur between two molecules, such as protein-bindin... | https://en.wikipedia.org/wiki?curid=42291886 |
Ligand binding assay ) The following equation determines the actual concentration: formula_1 Saturation analysis is used in various types of tissues, such as fractions of partially purified plasma from tissue homogenates, cells transfected with cloned receptors, and cells that are either in culture or isolated prior to... | https://en.wikipedia.org/wiki?curid=42291886 |
Ligand binding assay Nonlinear curve fitting programs, such as Equilibrium Binding Data Analysis (EBDA) and LIGAND, are used to calculate estimates of binding parameters from saturation and competition-binding experiments. EBDA performs the initial analysis, which converts measured radioactivity into molar concentratio... | https://en.wikipedia.org/wiki?curid=42291886 |
Ligand binding assay Radioactive assays are harmful in that they produce radioactive waste; whereas, non-radioactive ligand assays utilize a different method to avoid producing toxic waste. These methods include, but are not limited to, fluorescence polarization (FP), fluorescence resonance energy transfer (FRET), and ... | https://en.wikipedia.org/wiki?curid=42291886 |
Ligand binding assay The dipole-dipole interaction between the donor and the acceptor molecule transfers the energy from the donor to the acceptor molecule. If the ligand is bound to the receptor-antibody complex, then the acceptor will emit light. When using FRET, it is critical that there is a distance smaller than 1... | https://en.wikipedia.org/wiki?curid=42291886 |
Ligand binding assay The enzyme-linked immunosorbent assay (ELISA) or Western blotting are two different ways that the purified antigen (or multiple antigens) can be obtained and analyzed. This method involves purifying an antigen through the aid of an attached antibody on a solid (beaded) support, such as agarose resi... | https://en.wikipedia.org/wiki?curid=42291886 |
Ligand binding assay Artifacts are due to the different environments found within the different wells on the plate, especially near the edges and center of the wells. Such effects are known as well effects, edge effects, and plate effects. Thus, emphasizing the necessity to position assay designs in the correct manner ... | https://en.wikipedia.org/wiki?curid=42291886 |
Ligand binding assay HRP, fluorescent dye) can be used for on-bead determination or quantification of bound biomolecules. Filter assays are a solid phase ligand binding assay that use filters to measure the affinity between two molecules. In a filter binding assay, the filters are used to trap cell membranes by sucking... | https://en.wikipedia.org/wiki?curid=42291886 |
Ligand binding assay Information about the ligand-target interaction is obtained from the signal change over time and kinetic parameters such as the association rate constant k, the dissociation rate constant k and the affinity K can be calculated. By measuring the interaction directly on cells, no isolation of the tar... | https://en.wikipedia.org/wiki?curid=42291886 |
Ligand binding assay Drugs that act upon these receptors are incredibly selective in order to produce required responses from signaling molecules. Specific binding refers to the binding of a ligand to a receptor, and it is possible that there is more than one specific binding site for one ligand. Non specific binding r... | https://en.wikipedia.org/wiki?curid=42291886 |
Ligand binding assay Some technological advances include new binding reagents as alternatives to antibodies, alternative dye solutions and micro plate systems, and the development of a method to skip the filtration step, which is required in many ligand binding assay processes. A prominent signaling molecule in cells i... | https://en.wikipedia.org/wiki?curid=42291886 |
Ligand binding assay Ligands are radiolabeled using either 3H or 125I, and released into the assay. Since only the radioligands that directly bind to the beads initiate a signal, free-ligands do not interfere during the screening process. By nature, assays must be carried out in a controlled environment in vitro, so th... | https://en.wikipedia.org/wiki?curid=42291886 |
Dietzia psychralcaliphila is a facultatively psychrophilic alkaliphile that grows on hydrocarbons. It is aerobic, non-motile and gram-positive. The type strain is ILA-1 (= JCM 10987 = IAM14896 = NCIMB 13777). | https://en.wikipedia.org/wiki?curid=42294982 |
Methylaspartate may refer to: | https://en.wikipedia.org/wiki?curid=42296599 |
Methylaspartic acid may refer to: | https://en.wikipedia.org/wiki?curid=42296653 |
Protein chemical shift prediction is a branch of biomolecular nuclear magnetic resonance spectroscopy that aims to accurately calculate protein chemical shifts from protein coordinates. was first attempted in the late 1960s using semi-empirical methods applied to protein structures solved by X-ray crystallography. Sinc... | https://en.wikipedia.org/wiki?curid=42297996 |
Protein chemical shift prediction In this case, the three-dimensional structure can be used to estimate what the NMR chemical shifts should be and thereby simplify the process of assigning the experimentally observed chemical shifts. Predicted/estimated protein chemical shifts can also be used to identify incorrect or ... | https://en.wikipedia.org/wiki?curid=42297996 |
Protein chemical shift prediction By early 2000, several research groups realized that protein chemical shifts could be more efficiently and accurately calculated by combining different methods together as shown in Figure 1. This led to the development of several programs and web servers that rapidly calculate protein ... | https://en.wikipedia.org/wiki?curid=42297996 |
Nuclear magnetic resonance chemical shift re-referencing is a chemical analysis method for chemical shift referencing in biomolecular nuclear magnetic resonance (NMR). It has been estimated that up to 20% of 13C and up to 35% of 15N shift assignments are improperly referenced. Given that the structural and dynamic info... | https://en.wikipedia.org/wiki?curid=42298908 |
Nuclear magnetic resonance chemical shift re-referencing SHIFTCOR uses several simple statistical approaches and pre-determined cut-off values to identify and correct potential referencing, assignment and typographical errors. SHIFTCOR identifies potential chemical shift referencing problems by comparing the difference... | https://en.wikipedia.org/wiki?curid=42298908 |
Nuclear magnetic resonance chemical shift re-referencing By comparing the predicted shifts to the observed shifts, SHIFTCOR is able to accurately identify chemical shift reference offsets as well as potential mis-assignments. A key limitation to the SHIFTCOR approach is that requires that the 3D structure for the targe... | https://en.wikipedia.org/wiki?curid=42298908 |
Nuclear magnetic resonance chemical shift re-referencing In contrast to LACS and PANAV/PSSI, CheckShift uses secondary structure predicted from high-performance secondary structure prediction programs such as PSIPRED to iteratively adjust 13C and 15N chemical shifts so that their secondary shifts match the predicted se... | https://en.wikipedia.org/wiki?curid=42298908 |
Nuclear magnetic resonance chemical shift re-referencing 7% of the entries in the BMRB appear to be mis-referenced. Evidently, chemical shift referencing continues to be a significant, and as yet unresolved problem for the biomolecular NMR community. | https://en.wikipedia.org/wiki?curid=42298908 |
Northwestern blot The northwestern blot, also known as the northwestern assay, is a hybrid analytical technique of the western blot and the northern blot, and is used in molecular biology to detect interactions between RNA and proteins. A related technique, the western blot, is used to detect a protein of interest that... | https://en.wikipedia.org/wiki?curid=42301816 |
Northwestern blot Subsequently, other similar blotting techniques were created with similar nomenclature to detect different molecules or interactions between molecules. These techniques include the western blot (protein detection), the northern blot (RNA detection), the southwestern blot (DNA-protein interaction detec... | https://en.wikipedia.org/wiki?curid=42301816 |
Northwestern blot The incubation time during this process can vary depending on the concentration of the competitor RNA applied; though incubation time is typically one hour. After the incubation is complete, the blot is usually washed at least 3 times for 5 minutes each wash, in order to dilute out the RNA in the solu... | https://en.wikipedia.org/wiki?curid=42301816 |
Northwestern blot Advantages of northwestern blotting include the expedited detection of specific proteins that bind RNA, as well as the assessment of the approximate molecular weights of those proteins. The northwestern blot allows for detection of identified proteins in a way that is inexpensive. The blot is typicall... | https://en.wikipedia.org/wiki?curid=42301816 |
Lutetium-yttrium oxyorthosilicate Lutetium-yttrium oxyorthosilicate, also known as LYSO, is an inorganic chemical compound with main use as a scintillator crystal. Its chemical formula is LuYSiO. It is commonly used to build screens and electromagnetic calorimeters in particle physics. LYSO crystals have the advantages... | https://en.wikipedia.org/wiki?curid=42317866 |
Minigene A minigene is a minimal gene fragment that includes an exon and the control regions necessary for the gene to express itself in the same way as a wild type gene fragment. This is a minigene in its most basic sense. More complex minigenes can be constructed containing multiple exons and intron(s). Minigenes pro... | https://en.wikipedia.org/wiki?curid=42318629 |
Minigene Using minigenes as a splice reporting vector to explore the effects of RNA splicing regulation naturally followed and remains the major use of minigenes to date. In order to provide a good minigene model, the gene fragment should have all of the necessary elements to ensure it exhibits the same alternative spl... | https://en.wikipedia.org/wiki?curid=42318629 |
Minigene These types of experiments help to determine the effect of various mutations on pre-mRNA splicing. Once a suitable genomic fragment is chosen (Step 1), the exons and introns of the fragment can be inserted and amplified, along with the flanking constitutive exons and introns of the original gene, by PCR. The p... | https://en.wikipedia.org/wiki?curid=42318629 |
Minigene Determining the complete set of components involved in splicing presents many challenges due to the abundance of alternative splicing, which occurs in most human genes, and the specificity in which splicing is carried out "in vivo". Splicing is distinctly conducted from cell type to cell type and across differ... | https://en.wikipedia.org/wiki?curid=42318629 |
Minigene One specific example of a splicing error causing an endocrine disease that has been studied using minigenes is a type of growth hormone deficiency called isolated growth hormone deficiency (IGHD), a disease that results in growth failure. IGHD type II is an autosomal dominant form caused by a mutation in the i... | https://en.wikipedia.org/wiki?curid=42318629 |
Minigene Minigenes have been used by several researchers to help understand the regulatory components responsible for mRNA splicing of the TAU gene. Cancer is a complex, heterogeneous disease that can be hereditary or the result of environmental stimuli. Minigenes are used to help oncologists understand the roles pre-m... | https://en.wikipedia.org/wiki?curid=42318629 |
Sulfur (pharmacy) Sulfur is used in pharmaceutical skin preparations for the treatment of acne and other conditions. it acts as a keratolytic agent and also kills bacteria, fungi, scabies mites and other parasites. Chemically, it is the naturally occurring octasulfur (S). Precipitated sulfur and colloidal sulfur are us... | https://en.wikipedia.org/wiki?curid=42323764 |
Sulfur (pharmacy) Sulfur's keratolytic action is also mediated by HS; in this case, the hydrogen sulfide is produced by direct interaction with the target keratinocytes themselves. | https://en.wikipedia.org/wiki?curid=42323764 |
Biomaterials (journal) Biomaterials is a peer-reviewed scientific journal covering research on and applications of biomaterials. It is published by Elsevier and the editor-in-chief is Kam W. Leong (Columbia University). The journal was established in 1980. The journal is abstracted and indexed in: According to the "Jou... | https://en.wikipedia.org/wiki?curid=42332421 |
Beevers–Lipson strip Beevers–Lipson strips were a computational aid for early crystallographers in calculating Fourier transforms to determine the structure of crystals from crystallographic data, enabling the creation of models for complex molecules. They were used from the 1930s until computers with enough power beca... | https://en.wikipedia.org/wiki?curid=42333982 |
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