id stringlengths 16 65 | title stringlengths 19 278 | text stringlengths 894 136k | keyphrases listlengths 1 34 | prmu listlengths 1 34 |
|---|---|---|---|---|
Plant_Mol_Biol-4-1-2295252 | The microRNA regulated SBP-box genes SPL9 and SPL15 control shoot maturation in Arabidopsis
| Throughout development the Arabidopsis shoot apical meristem successively undergoes several major phase transitions such as the juvenile-to-adult and floral transitions until, finally, it will produce flowers instead of leaves and shoots. Members of the Arabidopsis SBP-box gene family of transcription factors have been... | [
"sbp-box genes",
"shoot maturation",
"arabidopsis",
"phase change",
"juvenile phase",
"mirna"
] | [
"P",
"P",
"P",
"P",
"P",
"P"
] |
Virus_Res-2-1-2194287 | Novel vectors expressing anti-apoptotic protein Bcl-2 to study cell death in Semliki Forest virus-infected cells
| Semliki Forest virus (SFV, Alphavirus) induce rapid shut down of host cell protein synthesis and apoptotic death of infected vertebrate cells. Data on alphavirus-induced apoptosis are controversial. In this study, the anti-apoptotic bcl-2 gene was placed under the control of duplicated subgenomic promoter or different ... | [
"bcl-2",
"cell death",
"semliki forest virus",
"alphaviruses",
"at3"
] | [
"P",
"P",
"P",
"P",
"P"
] |
Ann_Biomed_Eng-4-1-2239251 | Biomechanical Analysis of Reducing Sacroiliac Joint Shear Load by Optimization of Pelvic Muscle and Ligament Forces
| Effective stabilization of the sacroiliac joints (SIJ) is essential, since spinal loading is transferred via the SIJ to the coxal bones, and further to the legs. We performed a biomechanical analysis of SIJ stability in terms of reduced SIJ shear force in standing posture using a validated static 3-D simulation model. ... | [
"sacroiliac joints",
"pelvis",
"pelvic floor muscles",
"static forces",
"human posture"
] | [
"P",
"P",
"P",
"R",
"R"
] |
Mod_Rheumatol-4-1-2275302 | Gene therapy for arthritis
| Arthritis is among the leading causes of disability in the developed world. There remains no cure for this disease and the current treatments are only modestly effective at slowing the disease's progression and providing symptomatic relief. The clinical effectiveness of current treatment regimens has been limited by sh... | [
"gene therapy",
"gene transfer",
"rheumatoid arthritis",
"inflammation",
"cytokines"
] | [
"P",
"P",
"P",
"P",
"P"
] |
Pediatr_Nephrol-3-1-2064942 | Mechanisms of progression of chronic kidney disease
| Chronic kidney disease (CKD) occurs in all age groups, including children. Regardless of the underlying cause, CKD is characterized by progressive scarring that ultimately affects all structures of the kidney. The relentless progression of CKD is postulated to result from a self-perpetuating vicious cycle of fibrosis a... | [
"angiotensin",
"podocytes",
"interstitial fibrosis",
"glomerulosclerosis",
"low birth weight",
"angiotensin i converting enzyme inhibitors (acei)",
"angiotensin receptors",
"angiotensin receptor blockers",
"transforming growth factor (tgf)-beta"
] | [
"P",
"P",
"P",
"P",
"P",
"R",
"R",
"R",
"M"
] |
Crit_Care-8-2-420020 | Clinical review: The implications of experimental and clinical studies of recruitment maneuvers in acute lung injury
| Mechanical ventilation can cause and perpetuate lung injury if alveolar overdistension, cyclic collapse, and reopening of alveolar units occur. The use of low tidal volume and limited airway pressure has improved survival in patients with acute lung injury or acute respiratory distress syndrome. The use of recruitment ... | [
"acute lung injury",
"mechanical ventilation",
"mechanical stress",
"lung infection",
"lung collapse"
] | [
"P",
"P",
"P",
"P",
"P"
] |
Eur_J_Pediatr-3-1-1914296 | What is new in surgical treatment of vesicoureteric reflux?
| In addition to conventional open surgery and endoscopic techniques, laparoscopic correction of vesicoureteric reflux, sometimes even robot-assisted, is becoming an alternative surgical treatment modality for this condition in a number of centres around the world. At least for a subgroup of patients laparoscopists are t... | [
"vesicoureteric reflux",
"laparoscopy"
] | [
"P",
"P"
] |
Ann_Surg_Oncol-3-1-2077912 | Population-Based Study of Islet Cell Carcinoma
| Background We examine the epidemiology, natural history, and prognostic factors that affect the duration of survival for islet cell carcinoma by using population-based registries.
Islet cell carcinomas are low- to intermediate-grade neuroendocrine carcinomas of the pancreas. Also known as pancreatic endocrine tumors or... | [
"islet cell",
"epidemiology",
"survival",
"pancreatic endocrine tumor",
"neuroendocrine tumor"
] | [
"P",
"P",
"P",
"P",
"P"
] |
Exp_Eye_Res-2-1-2394572 | Pharmacological disruption of the outer limiting membrane leads to increased retinal integration of transplanted photoreceptor precursors
| Retinal degeneration is the leading cause of untreatable blindness in the developed world. Cell transplantation strategies provide a novel therapeutic approach to repair the retina and restore sight. Previously, we have shown that photoreceptor precursor cells can integrate and form functional photoreceptors after tran... | [
"outer limiting membrane",
"photoreceptor",
"mouse",
"cell integration",
"stem cells",
"müller cell",
"retinal transplantation"
] | [
"P",
"P",
"P",
"P",
"P",
"P",
"R"
] |
Eur_Spine_J-2-2-1602185 | In-vivo demonstration of the effectiveness of thoracoscopic anterior release using the fulcrum-bending radiograph: a report of five cases
| Thoracoscopic anterior release of stiff scoliotic curves is favored because of its minimally invasive nature. Animal and human cadaveric studies have shown that it can effectively improve spinal flexibility in non-scoliotic spines; however it has not been demonstrated to be effective in actual patients with scoliosis. ... | [
"anterior release",
"spinal flexibility",
"adolescent idiopathic scoliosis",
"video-assisted thoracoscopic surgery",
"thoracoscopy"
] | [
"P",
"P",
"P",
"P",
"P"
] |
Qual_Life_Res-3-1-2039790 | Different perceptions of the burden of upper GI endoscopy: an empirical study in three patient groups
| Background Few studies have evaluated patients’ perceived burden of cancer surveillance tests. Cancer screening and surveillance, however, require a large number of patients to undergo potentially burdensome tests with only some experiencing health gains from it. We investigated the determinants of patients’ reported b... | [
"barrett esophagus",
"endoscopic surveillance",
"discomfort",
"anxiety",
"distress",
"upper gastrointestinal endoscopy",
"perceived patient burden"
] | [
"P",
"P",
"P",
"P",
"P",
"R",
"R"
] |
Clin_Rheumatol-3-1-2039777 | A comparison of the measurement properties of the Juvenile Arthritis Functional Assessment Scale with the childhood health assessment questionnaire in daily practice
| We compared the measurement properties of a performance test (Juvenile Arthritis Functional Assessment Scale; JAFAS) with a questionnaire-based instrument (Childhood Health Assessment Questionnaire; CHAQ) to measure functional ability in patients with juvenile idiopathic arthritis on the level of individual items. In 2... | [
"questionnaire",
"juvenile idiopathic arthritis",
"activities of daily living",
"disability evaluation"
] | [
"P",
"P",
"M",
"R"
] |
Matern_Child_Health_J-2-2-1592249 | Preconception Healthcare: What Women Know and Believe
| Objectives: The objectives of this study were to determine if women realize the importance of optimizing their health prior to a pregnancy, whether the pregnancy is planned or not; and to evaluate their knowledge level and beliefs about preconception healthcare. Additionally, we sought to understand how and when women ... | [
"preconception health",
"primary care",
"preconception care",
"women’s health"
] | [
"P",
"P",
"P",
"P"
] |
J_Gastrointest_Surg-3-1-1852384 | Factors Affecting Morbidity and Mortality of Roux-en-Y Gastric Bypass for Clinically Severe Obesity: An Analysis of 1,000 Consecutive Open Cases by a Single Surgeon
| Introduction Determinants of perioperative risk for RYGB are not well defined.
Introduction
Obesity is currently the number one public health problem in the United States, affecting one-third of all Americans (http:/www.surgeongeneral.gov/topics/obesity). Approximately 5 to 8% have clinically severe or morbid obesity a... | [
"morbidity",
"mortality",
"roux-en-y gastric bypass",
"obesity",
"morbid obesity"
] | [
"P",
"P",
"P",
"P",
"P"
] |
Clin_Rheumatol-4-1-2367392 | Tracheobronchomalacia due to amyloidosis in a patient with rheumatoid arthritis
| In this case report, we describe a patient with longstanding rheumatoid arthritis who developed tracheobronchomalacia with fatal outcome. Despite negative antemortem biopsies of abdominal fat and tongue, amyloid was found postmortem in the trachea and appeared to be associated with tracheobronchomalacia.
Introduction
A... | [
"tracheobronchomalacia",
"amyloidosis",
"rheumatoid arthritis",
"kidney"
] | [
"P",
"P",
"P",
"P"
] |
Pediatr_Radiol-3-1-1805044 | 2005 PRETEXT: a revised staging system for primary malignant liver tumours of childhood developed by the SIOPEL group
| Over the last 15 years, various oncology groups throughout the world have used the PRETEXT system for staging malignant primary liver tumours of childhood. This paper, written by members of the radiology and surgery committees of the International Childhood Liver Tumor Strategy Group (SIOPEL), presents various clarific... | [
"staging",
"liver",
"tumour",
"children",
"hepatoblastoma"
] | [
"P",
"P",
"P",
"P",
"P"
] |
Trans_R_Soc_Trop_Med_Hyg-1-5-1950430 | Associations between mild-to-moderate anaemia in pregnancy and helminth, malaria and HIV infection in Entebbe, Uganda
| Summary
1
Introduction
Anaemia in pregnancy contributes to maternal deaths and may also contribute to adverse birth outcomes including intrauterine growth retardation and prematurity, and hence to perinatal morbidity and mortality (WHO, 1991).
Hookworm is an important cause of anaemia in developing countries, but lack ... | [
"anaemia",
"pregnancy",
"helminth",
"malaria",
"hiv",
"uganda"
] | [
"P",
"P",
"P",
"P",
"P",
"P"
] |
Osteoporos_Int-3-1-1766476 | A multidisciplinary, multifactorial intervention program reduces postoperative falls and injuries after femoral neck fracture
| Introduction This study evaluates whether a postoperative multidisciplinary, intervention program, including systematic assessment and treatment of fall risk factors, active prevention, detection, and treatment of postoperative complications, could reduce inpatient falls and fall-related injuries after a femoral neck f... | [
"intervention",
"hip fracture",
"in-hospital",
"accidental falls",
"elderly"
] | [
"P",
"P",
"P",
"M",
"U"
] |
Anal_Bioanal_Chem-3-1-1592466 | Capillary-assembled microchip as an on-line deproteinization device for capillary electrophoresis
| A capillary-assembled microchip (CAs-CHIP), prepared by simply embedding square capillaries in a lattice polydimethylsiloxane (PDMS) channel plate with the same channel dimensions as the outer dimensions of the square capillaries, has been used as a diffusion-based pretreatment attachment in capillary electrophoresis (... | [
"capillary-assembled microchip",
"deproteinization",
"capillary electrophoresis",
"square capillary",
"polydimethylsiloxane"
] | [
"P",
"P",
"P",
"P",
"P"
] |
Bioinformation-1-1-1891626 | AVATAR: A database for genome-wide alternative splicing event detection using large scale ESTs and mRNAs
| In the past years, identification of alternative splicing (AS) variants has been gaining momentum. We developed AVATAR, a database for documenting AS using 5,469,433 human EST sequences and 26,159 human mRNA sequences. AVATAR contains 12000 alternative splicing sites identified by mapping ESTs and mRNAs with the whole ... | [
"database",
"alternative splicing",
"est",
"mrna",
"human",
"eukaryotes",
"protein diversity",
"sequence alignment"
] | [
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"R"
] |
Eur_Spine_J-4-1-2226191 | High failure rate of the interspinous distraction device (X-Stop) for the treatment of lumbar spinal stenosis caused by degenerative spondylolisthesis
| The X-Stop interspinous distraction device has shown to be an attractive alternative to conventional surgical procedures in the treatment of symptomatic degenerative lumbar spinal stenosis. However, the effectiveness of the X-Stop in symptomatic degenerative lumbar spinal stenosis caused by degenerative spondylolisthes... | [
"x-stop",
"lumbar spinal stenosis",
"degenerative spondylolisthesis"
] | [
"P",
"P",
"P"
] |
Doc_Ophthalmol-3-1-1784540 | Multifocal ERG findings in carriers of X-linked retinoschisis
| Purpose To determine whether retinal dysfunction in obligate carriers of X-linked retinoschisis (XLRS) could be observed in local electroretinographic responses obtained with the multifocal electroretinogram (mfERG). Methods Nine obligate carriers of XLRS (mean age, 46.2 years) were examined for the study. Examination ... | [
"carriers",
"x-linked retinoschisis",
"situs inversus",
"multifocal electroretinography"
] | [
"P",
"P",
"P",
"M"
] |
Bioprocess_Biosyst_Eng-2-2-1705532 | A next generation, pilot-scale continuous sterilization system for fermentation media
| A new continuous sterilization system was designed, constructed, started up, and qualified for media sterilization for secondary metabolite cultivations, bioconversions, and enzyme production. An existing Honeywell Total Distributed Control 3000-based control system was extended using redundant High performance Process... | [
"continuous sterilizer",
"pilot scale",
"high temperature short time",
"spiral heat exchanger",
"start-up"
] | [
"P",
"P",
"R",
"R",
"U"
] |
Virchows_Arch-4-1-2329733 | Validation of tissue microarray technology in squamous cell carcinoma of the esophagus
| Tissue microarray (TMA) technology has been developed to facilitate high-throughput immunohistochemical and in situ hybridization analysis of tissues by inserting small tissue biopsy cores into a single paraffin block. Several studies have revealed novel prognostic biomarkers in esophageal squamous cell carcinoma (ESCC... | [
"squamous cell carcinoma",
"validation studies",
"biological markers",
"esophageal neoplasms",
"protein microarray analysis"
] | [
"P",
"P",
"M",
"M",
"R"
] |
Pediatr_Nephrol-3-1-1766478 | Renal replacement therapy for acute renal failure in children: European Guidelines
| Acute renal failure (ARF) is uncommon in childhood and there is little consensus on the appropriate treatment modality when renal replacement therapy is required. Members of the European Pediatric Peritoneal Dialysis Working Group have produced the following guidelines in collaboration with nursing staff. Good practice... | [
"acute renal failure",
"guidelines",
"peritoneal dialysis",
"hemodialysis",
"hemofiltration"
] | [
"P",
"P",
"P",
"P",
"P"
] |
Eur_Radiol-3-1-1797072 | MR imaging of therapy-induced changes of bone marrow
| MR imaging of bone marrow infiltration by hematologic malignancies provides non-invasive assays of bone marrow cellularity and vascularity to supplement the information provided by bone marrow biopsies. This article will review the MR imaging findings of bone marrow infiltration by hematologic malignancies with special... | [
"mr imaging",
"bone marrow",
"treatment effects",
"contrast agents"
] | [
"P",
"P",
"P",
"P"
] |
Intensive_Care_Med-4-1-2271079 | Factors associated with posttraumatic stress symptoms in a prospective cohort of patients after abdominal sepsis: a nomogram
| Objective To determine to what extent patients who have survived abdominal sepsis suffer from symptoms of posttraumatic stress disorder (PTSD) and depression, and to identify potential risk factors for PTSD symptoms.
Introduction
Posttraumatic stress disorder (PTSD) is the development of psychological and physical symp... | [
"sepsis",
"posttraumatic stress disorder",
"ptsd",
"depression",
"intensive care",
"peritonitis",
"ptss-10",
"ies-r",
"bdi-ii"
] | [
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"P"
] |
Eur_J_Pediatr-3-1-1802727 | The probiotic Escherichia coli strain Nissle 1917 (EcN) stops acute diarrhoea in infants and toddlers
| In most cases, acute diarrhoea will become self-limiting during the first few days after onset. For young children, however, health risks may develop when the disease lasts longer than 3 days. The purpose of the present trial was to determine whether the stool frequency of infants and toddlers suffering from acute diar... | [
"probiotic",
"ecn",
"acute diarrhoea",
"infants",
"toddlers",
"escherichia coli nissle 1917"
] | [
"P",
"P",
"P",
"P",
"P",
"P"
] |
Eur_Spine_J-2-2-1602181 | Os odontoideum with bipartite atlas and segmental instability: a case report
| We report on the case of a 15-year-old adolescent who presented with a transient paraplegia and hyposensibility of the upper extremities after sustaining a minor hyperflexion trauma to the cervical spine. Neuroimaging studies revealed atlantoaxial dislocation and ventral compression of the rostral spinal cord with incr... | [
"os odontoideum",
"atlantoaxial instability",
"c1/c2 fusion",
"midline cleft of atlas"
] | [
"P",
"P",
"R",
"R"
] |
Purinergic_Signal-2-2-2254478 | The E-NTPDase family of ectonucleotidases: Structure function relationships and pathophysiological significance
| Ectonucleotidases are ectoenzymes that hydrolyze extracellular nucleotides to the respective nucleosides. Within the past decade, ectonucleotidases belonging to several enzyme families have been discovered, cloned and characterized. In this article, we specifically address the cell surface-located members of the ecto-n... | [
"ntpdase",
"cd39",
"vasculature",
"nervous tissue",
"apyrase",
"ecto-atpase",
"immunology",
"platelet",
"liver",
"ischemia",
"brain",
"kidney"
] | [
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"P"
] |
Eur_J_Pediatr-3-1-2151776 | What is new in pertussis?
| Despite high vaccination coverage, over the last fifteen years there has been a worldwide resurgence of B. pertussis infection. While classical pertussis in the prevaccine era was primarily a childhood disease, today with widespread vaccination, there has been a shift in the incidence of disease to adolescents and adul... | [
"immunization strategies",
"review",
"bordetella pertussis",
"polymerase chain reaction (pcr)"
] | [
"P",
"P",
"R",
"M"
] |
Intensive_Care_Med-4-1-2249616 | Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008
| Objective To provide an update to the original Surviving Sepsis Campaign clinical management guidelines, “Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock,” published in 2004.
Introduction
Severe sepsis (acute organ dysfunction secondary to infection) and septic shock (severe sepsis... | [
"surviving sepsis campaign",
"sepsis",
"guidelines",
"severe sepsis",
"septic shock",
"infection",
"sepsis syndrome",
"grade",
"sepsis bundles",
"evidence-based medicine"
] | [
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"R"
] |
Ann_Gen_Hosp_Psychiatry-2-_-162166 | Contribution of psychoacoustics and neuroaudiology in revealing correlation of mental disorders with central auditory processing disorders
| Background Psychoacoustics is a fascinating developing field concerned with the evaluation of the hearing sensation as an outcome of a sound or speech stimulus. Neuroaudiology with electrophysiologic testing, records the electrical activity of the auditory pathways, extending from the 8th cranial nerve up to the cortic... | [
"psychoacoustics",
"mental disorders",
"central auditory processing disorders"
] | [
"P",
"P",
"P"
] |
Rheumatol_Int-3-1-2134974 | The potential utility of B cell-directed biologic therapy in autoimmune diseases
| Increasing awareness of the importance of aberrant B cell regulation in autoimmunity has driven the clinical development of novel B cell-directed biologic therapies with the potential to treat a range of autoimmune disorders. The first of these drugs—rituximab, a chimeric monoclonal antibody against the B cell-specific... | [
"biologic therapies",
"rituximab",
"cd20",
"lupus",
"sjögren’s syndrome",
"vasculitis",
"thrombocytopenic purpura",
"b-lymphocytes"
] | [
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"U"
] |
Pediatr_Nephrol-3-1-2064944 | Chronic kidney disease in children: the global perspective
| In contrast to the increasing availability of information pertaining to the care of children with chronic kidney disease (CKD) from large-scale observational and interventional studies, epidemiological information on the incidence and prevalence of pediatric CKD is currently limited, imprecise, and flawed by methodolog... | [
"chronic kidney disease",
"children",
"epidemiology",
"end-stage renal disease",
"renal replacement therapy"
] | [
"P",
"P",
"P",
"P",
"P"
] |
Surg_Endosc-4-1-2358937 | Perioperative outcome of laparoscopic left lateral liver resection is improved by using a bioabsorbable staple line reinforcement material in a porcine model
| Hypothesis Laparoscopic liver surgery is significantly limited by the technical difficulty encountered during transection of substantial liver parenchyma, with intraoperative bleeding and bile leaks. This study tested whether the use of a bioabsorble staple line reinforcement material would improve outcome during stapl... | [
"liver resections",
"staple line reinforcement",
"laparoscopic surgery",
"complications",
"bile duct leak",
"hemorrhage."
] | [
"P",
"P",
"P",
"P",
"R",
"M"
] |
Eur_J_Epidemiol-3-1-2071962 | Sodium and potassium intake and risk of cardiovascular events and all-cause mortality: the Rotterdam Study
| Background Dietary electrolytes influence blood pressure, but their effect on clinical outcomes remains to be established. We examined sodium and potassium intake in relation to cardiovascular disease (CVD) and mortality in an unselected older population. Methods A case–cohort analysis was performed in the Rotterdam St... | [
"sodium",
"potassium",
"mortality",
"cardiovascular disease",
"myocardial infarction",
"stroke",
"population-based",
"salt"
] | [
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"P"
] |
Int_J_Hematol-4-1-2276241 | Diagnosis of acute myeloid leukemia according to the WHO classification in the Japan Adult Leukemia Study Group AML-97 protocol
| We reviewed and categorized 638 of 809 patients who were registered in the Japan Adult Leukemia Study Group acute myeloid leukemia (AML)-97 protocol using morphological means. Patients with the M3 subtype were excluded from the study group. According to the WHO classification, 171 patients (26.8%) had AML with recurren... | [
"who classification",
"aml",
"myeloperoxidase",
"11q23 abnormalities",
"multilineage dyplasia"
] | [
"P",
"P",
"P",
"P",
"M"
] |
Purinergic_Signal-3-1-2096770 | P2 receptors in atherosclerosis and postangioplasty restenosis
| Atherosclerosis is an immunoinflammatory process that involves complex interactions between the vessel wall and blood components and is thought to be initiated by endothelial dysfunction [Ross (Nature 362:801–09, 1993); Fuster et al. (N Engl J Med 326:242–50, 1992); Davies and Woolf (Br Heart J 69:S3–S11, 1993)]. Extra... | [
"atherosclerosis",
"restenosis",
"inflammation",
"proliferation",
"migration",
"smooth muscle cell",
"nucleotide receptors"
] | [
"P",
"P",
"P",
"P",
"P",
"P",
"P"
] |
J_Gastrointest_Surg-3-1-1852385 | Controversies in the Surgical Management of Sigmoid Diverticulitis
| The timing and appropriateness of surgical treatment of sigmoid diverticular disease remain a topic of controversy. We have reviewed the current literature on this topic, focusing on issues related to the indications and types of surgery. Current evidence would suggest that elective surgery for diverticulitis can be av... | [
"surgical management",
"sigmoid diverticulitis",
"elective surgery",
"diagnosis"
] | [
"P",
"P",
"P",
"P"
] |
Health_Care_Anal-4-1-2244696 | Social Patterning of Screening Uptake and the Impact of Facilitating Informed Choices: Psychological and Ethical Analyses
| Screening for unsuspected disease has both possible benefits and harms for those who participate. Historically the benefits of participation have been emphasized to maximize uptake reflecting a public health approach to policy; currently policy is moving towards an informed choice approach involving giving information ... | [
"screening",
"informed choice",
"public health approach",
"health inequality",
"paternalism",
"autonomy",
"utilitarianism",
"prioritarianism",
"egalitarianism"
] | [
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"P"
] |
Oecologia-3-1-2039789 | Costs and benefits of induced resistance in a clonal plant network
| Plant defense theory suggests that inducible resistance has evolved to reduce the costs of constitutive defense expression. To assess the functional and potentially adaptive value of induced resistance it is necessary to quantify the costs and benefits associated with this plastic response. The ecological and evolution... | [
"plant defense",
"trifolium repens",
"physiological integration",
"adaptive plasticity hypothesis",
"plant communication"
] | [
"P",
"P",
"P",
"P",
"M"
] |
Mol_Hum_Reprod-1-1-2408934 | In utero exposure to low doses of environmental pollutants disrupts fetal ovarian development in sheep
| Epidemiological studies of the impact of environmental chemicals on reproductive health demonstrate consequences of exposure but establishing causative links requires animal models using ‘real life’ in utero exposures. We aimed to determine whether prolonged, low-dose, exposure of pregnant sheep to a mixture of environ... | [
"environmental chemicals",
"sewage sludge",
"oocyte",
"fetal development",
"granulosa cell"
] | [
"P",
"P",
"P",
"P",
"P"
] |
Diabetologia-3-1-1914278 | Perturbation of hyaluronan metabolism predisposes patients with type 1 diabetes mellitus to atherosclerosis
| Aims/hypothesis Cardiovascular disease contributes to mortality in type 1 diabetes mellitus, but the specific pathophysiological mechanisms remain to be established. We recently showed that the endothelial glycocalyx, a protective layer of proteoglycans covering the endothelium, is severely perturbed in type 1 diabetes... | [
"hyaluronan",
"type 1 diabetes mellitus",
"hyaluronidase",
"intima-media thickness"
] | [
"P",
"P",
"P",
"P"
] |
Anal_Bioanal_Chem-3-1-1839866 | Biochemical applications of surface-enhanced infrared absorption spectroscopy
| An overview is presented on the application of surface-enhanced infrared absorption (SEIRA) spectroscopy to biochemical problems. Use of SEIRA results in high surface sensitivity by enhancing the signal of the adsorbed molecule by approximately two orders of magnitude and has the potential to enable new studies, from f... | [
"electron transfer",
"protein",
"self-assembled monolayer",
"membrane",
"ftir"
] | [
"P",
"P",
"P",
"P",
"P"
] |
Diabetologia-3-1-1871609 | The role of physical activity in the management of impaired glucose tolerance: a systematic review
| Although physical activity is widely reported to reduce the risk of type 2 diabetes in individuals with prediabetes, few studies have examined this issue independently of other lifestyle modifications. The aim of this review is to conduct a systematic review of controlled trials to determine the independent effect of e... | [
"physical activity",
"impaired glucose tolerance",
"type 2 diabetes",
"prediabetes",
"exercise",
"igt",
"ifg",
"prevention",
"impaired fasting glucose"
] | [
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"P"
] |
Arch_Orthop_Trauma_Surg-4-1-2324129 | Closed reduction and percutaneus Kirschner wire fixation for the treatment of dislocated calcaneal fractures: surgical technique, complications, clinical and radiological results after 2–10 years
| Introduction To reduce complications, a minimally invasive technique for the treatment of dislocated intraarticular fractures of the calcaneus was used. Therefore previously described closed reduction and internal fixation techniques were combined and modified.
Introduction
A fracture of the calcaneus allowed to heal i... | [
"dislocated calcaneal fracture",
"minimal-invasive"
] | [
"P",
"U"
] |
Purinergic_Signal-3-4-2072916 | Guanosine reduces apoptosis and inflammation associated with restoration of function in rats with acute spinal cord injury
| Spinal cord injury results in progressive waves of secondary injuries, cascades of noxious pathological mechanisms that substantially exacerbate the primary injury and the resultant permanent functional deficits. Secondary injuries are associated with inflammation, excessive cytokine release, and cell apoptosis. The pu... | [
"guanosine",
"apoptosis",
"inflammation",
"spinal cord injury",
"cell death",
"myelin",
"immunohistochemistry",
"glia",
"locomotor and sensory function"
] | [
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"U",
"R"
] |
Behav_Genet-4-1-2226020 | Genetic and Environmental Influences on the Relation Between Attention Problems and Attention Deficit Hyperactivity Disorder
| Objective The assessment of symptoms of ADHD in children is usually based on a clinical interview or a behavior checklist. The aim of the present study is to investigate the extent to which these instruments measure an underlying construct and to estimate the genetic and environmental influences on individual differenc... | [
"genetics",
"attention problems",
"adhd",
"measurement",
"twins",
"multivariate analysis"
] | [
"P",
"P",
"P",
"P",
"P",
"R"
] |
Breast_Cancer_Res_Treat-3-1-2096637 | MRI compared to conventional diagnostic work-up in the detection and evaluation of invasive lobular carcinoma of the breast: a review of existing literature
| Purpose The clinical diagnosis and management of invasive lobular carcinoma (ILC) of the breast presents difficulties. Magnetic resonance imaging (MRI) has been proposed as the imaging modality of choice for the evaluation of ILC. Small studies addressing different aspects of MRI in ILC have been presented but no large... | [
"invasive lobular carcinoma of the breast",
"magnetic resonance imaging",
"sensitivity",
"morphology",
"additional findings",
"impact on treatment"
] | [
"P",
"P",
"P",
"P",
"P",
"R"
] |
Arch_Dermatol_Res-3-1-1950585 | Preservation of skin DNA for oligonucleotide array CGH studies: a feasibility study
| Array-based comparative genomic hybridization (a-CGH) is a promising tool for clinical genomic studies. However, pre-analytical sample preparation methods have not been fully evaluated for this purpose. Parallel sections of normal male human skin biopsy samples were collected and immediately immersed in saline, formali... | [
"genomics",
"fixatives",
"array comparative genomic hybridization",
"tissue preservation"
] | [
"P",
"P",
"R",
"R"
] |
J_Gastrointest_Surg-3-1-1852375 | Intestinal Perforations in Behçet’s Disease
| Behçet’s disease accompanied by intestinal involvement is called intestinal Behçet’s disease. The intestinal ulcers of Behçet’s disease are usually multiple and scattered and tend to perforate easily, so that many patients require emergency operation. The aim of this study is to determine the extent of surgical resecti... | [
"intestinal perforations",
"behçet’s disease",
"intestinal ulcers"
] | [
"P",
"P",
"P"
] |
Domest_Anim_Endocrinol-2-1-2428105 | Endometrial expression of the insulin-like growth factor system during uterine involution in the postpartum dairy cow☆
| Rapid uterine involution in the postpartum period of dairy cows is important to achieve a short interval to conception. Expression patterns for members of the insulin-like growth factor (IGF) family were determined by in situ hybridisation at day 14 ± 0.4 postpartum (n = 12 cows) to investigate a potential role for IGF... | [
"involution",
"igf",
"igfbp",
"uterus",
"bovine"
] | [
"P",
"P",
"P",
"P",
"P"
] |
Evid_Based_Complement_Alternat_Med-3-4-1697739 | The Use of Herbal Medicine in Alzheimer's Disease—A Systematic Review
| The treatments of choice in Alzheimer's disease (AD) are cholinesterase inhibitors and NMDA-receptor antagonists, although doubts remain about the therapeutic effectiveness of these drugs. Herbal medicine products have been used in the treatment of Behavioral and Psychological Symptoms of Dementia (BPSD) but with vario... | [
"herbs",
"alzheimer's disease",
"systematic review",
"dementia",
"elderly",
"cognitive impairment",
"randomized clinical trial"
] | [
"P",
"P",
"P",
"P",
"P",
"P",
"R"
] |
Bioinformation-1-10-1896055 | Integrative analysis of the mouse embryonic transcriptome
| Monitoring global gene expression provides insight into how genes and regulatory signals work together to guide embryo development. The fields of developmental biology and teratology are now confronted with the need for automated access to a reference library of gene-expression signatures that benchmark programmed (gen... | [
"integrative analysis",
"mouse",
"embryo",
"transcriptome",
"expression",
"birth defects"
] | [
"P",
"P",
"P",
"P",
"P",
"P"
] |
Pediatr_Nephrol-3-1-1989763 | Nutrition in children with CRF and on dialysis
| The objectives of this study are: (1) to understand the importance of nutrition in normal growth; (2) to review the methods of assessing nutritional status; (3) to review the dietary requirements of normal children throughout childhood, including protein, energy, vitamins and minerals; (4) to review recommendations for... | [
"nutrition",
"dialysis",
"growth",
"chronic renal failure"
] | [
"P",
"P",
"P",
"P"
] |
Pediatr_Radiol-3-1-1891641 | Doppler waveforms of the ureteric jet: an overview and implications for the presence of a functional sphincter at the vesicoureteric junction
| This paper is a comprehensive review of the Doppler waveform appearance of ureteric jets. Six jet waveform patterns have been identified: monophasic, biphasic, triphasic, polyphasic, square and continuous. Details of the physical properties of jet patterns and their changes under various physiological conditions are il... | [
"doppler",
"ureteric jet",
"vesicoureteric junction",
"children",
"ultrasound"
] | [
"P",
"P",
"P",
"P",
"U"
] |
Biochem_Pharmacol-1-5-1920586 | Inhibition of the HERG potassium channel by the tricyclic antidepressant doxepin
| HERG (human ether-à-go-go-related gene) encodes channels responsible for the cardiac rapid delayed rectifier potassium current, IKr. This study investigated the effects on HERG channels of doxepin, a tricyclic antidepressant linked to QT interval prolongation and cardiac arrhythmia. Whole-cell patch-clamp recordings we... | [
"herg",
"potassium channel",
"antidepressant",
"doxepin",
"rapid delayed rectifier",
"qt interval",
"arrhythmia",
"short qt syndrome",
"torsade de pointes",
"i kr",
"long qt syndrome",
"qt-prolongation"
] | [
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"M",
"M",
"U"
] |
Diabetologia-4-1-2292427 | What is the mechanism of microalbuminuria in diabetes: a role for the glomerular endothelium?
| Microalbuminuria is an important risk factor for cardiovascular disease and progressive renal impairment. This holds true in the general population and particularly in those with diabetes, in whom it is common and marks out those likely to develop macrovascular disease and progressive renal impairment. Understanding th... | [
"microalbuminuria",
"diabetes",
"podocyte",
"glomerular filtration barrier",
"glycocalyx",
"glomerular endothelial cell"
] | [
"P",
"P",
"P",
"P",
"P",
"P"
] |
Environ_Manage-4-1-2242854 | Headwater Influences on Downstream Water Quality
| We investigated the influence of riparian and whole watershed land use as a function of stream size on surface water chemistry and assessed regional variation in these relationships. Sixty-eight watersheds in four level III U.S. EPA ecoregions in eastern Kansas were selected as study sites. Riparian land cover and wate... | [
"water quality",
"riparian zones",
"nonpoint source pollution",
"geographic information systems",
"headwater streams",
"watershed management"
] | [
"P",
"P",
"P",
"P",
"P",
"R"
] |
Arch_Dermatol_Res-3-1-1839867 | The relevance of the IgG subclass of autoantibodies for blister induction in autoimmune bullous skin diseases
| Autoimmune bullous skin diseases are characterized by autoantibodies and T cells specific to structural proteins maintaining cell–cell and cell–matrix adhesion in the skin. Existing clinical and experimental evidence generally supports a pathogenic role of autoantibodies for blister formation. These autoantibodies belo... | [
"igg subclasses",
"complement",
"autoimmune bullous diseases"
] | [
"P",
"P",
"P"
] |
Diabetologia-3-1-1794135 | Adiponectin receptor genes: mutation screening in syndromes of insulin resistance and association studies for type 2 diabetes and metabolic traits in UK populations
| Aims/hypothesis Adiponectin is an adipokine with insulin-sensitising and anti-atherogenic properties. Several reports suggest that genetic variants in the adiponectin gene are associated with circulating levels of adiponectin, insulin sensitivity and type 2 diabetes risk. Recently two receptors for adiponectin have bee... | [
"insulin resistance",
"association studies",
"type 2 diabetes",
"adipor1",
"adipor2",
"polymorphisms"
] | [
"P",
"P",
"P",
"P",
"P",
"P"
] |
Oecologia-3-1-2039837 | Geographic and seasonal patterns and limits on the adaptive response to temperature of European Mytilus spp. and Macoma balthica populations
| Seasonal variations in seawater temperature require extensive metabolic acclimatization in cold-blooded organisms inhabiting the coastal waters of Europe. Given the energetic costs of acclimatization, differences in adaptive capacity to climatic conditions are to be expected among distinct populations of species that a... | [
"metabolic rate",
"climate change",
"respiration rate",
"distribution range",
"thermal tolerance"
] | [
"P",
"P",
"P",
"P",
"P"
] |
Int_J_Cardiovasc_Imaging-3-1-2048827 | Assessment of normal tricuspid valve anatomy in adults by real-time three-dimensional echocardiography
| Background The tricuspid valve (TV) is a complex structure. Unlike the aortic and mitral valve it is not possible to visualize all TV leaflets simultaneously in one cross-sectional view by standard two-dimensional echocardiography (2DE) either transthoracic or transesophageal due to the position of TV in the far field.... | [
"normal tricuspid valve",
"real-time three-dimensional echocardiography",
"tricuspid valve anatomical structure"
] | [
"P",
"P",
"R"
] |
Diabetologia-4-1-2170456 | Duration of breast-feeding and the incidence of type 2 diabetes mellitus in the Shanghai Women’s Health Study
| Aims/hypothesis The aim of this study was to examine the association between lifetime breast-feeding and the incidence of type 2 diabetes mellitus in a large population-based cohort study of middle-aged women.
Introduction
The prevalence of type 2 diabetes mellitus has been increasing rapidly worldwide [1], making know... | [
"type 2 diabetes mellitus",
"middle-aged women",
"parous women",
"lifelong breast-feeding"
] | [
"P",
"P",
"P",
"M"
] |
Virchows_Arch-3-1-2039817 | Primary retroperitoneal mucinous cystadenoma with sarcoma-like mural nodule
| Primary retroperitoneal cystadenomas are extremely rare. This is the first report in literature to describe a primary retroperitoneal cystadenoma with a sarcoma-like mural nodule. A 45-year-old woman complained of a left-sided abdominal mass. A computed tomography scan revealed a cystic mass with a mural nodule, which ... | [
"mucinous cystadenoma",
"mural nodule",
"retroperitoneum"
] | [
"P",
"P",
"P"
] |
Environ_Health_Perspect-115-3-1849945 | Cumulative Lead Dose and Cognitive Function in Adults: A Review of Studies That Measured Both Blood Lead and Bone Lead
| Objective We review empirical evidence for the relations of recent and cumulative lead dose with cognitive function in adults.
In the development of the adult lead management guidelines (see Kosnett et al. 2007), a number of health outcomes adversely affected by lead exposure were discussed. Cognitive function was an i... | [
"lead",
"cognitive function",
"adults",
"blood",
"bone",
"neurobehavior"
] | [
"P",
"P",
"P",
"P",
"P",
"P"
] |
Eur_J_Pediatr-3-1-1820762 | ADAMTS13 phenotype in plasma from normal individuals and patients with thrombotic thrombocytopenic purpura
| The activity of ADAMTS13, the von Willebrand factor cleaving protease, is deficient in patients with thrombotic thrombocytopenic purpura (TTP). In the present study, the phenotype of ADAMTS13 in TTP and in normal plasma was demonstrated by immunoblotting. Normal plasma (n = 20) revealed a single band at 190 kD under re... | [
"adamts13",
"plasma",
"thrombotic thrombocytopenic purpura",
"von willebrand factor",
"von willebrand factor cleaving protease",
"immunoblotting"
] | [
"P",
"P",
"P",
"P",
"P",
"P"
] |
Pediatr_Nephrol-3-1-1805051 | Iron therapy for renal anemia: how much needed, how much harmful?
| Iron deficiency is the most common cause of hyporesponsiveness to erythropoiesis-stimulating agents (ESAs) in end-stage renal disease (ESRD) patients. Iron deficiency can easily be corrected by intravenous iron administration, which is more effective than oral iron supplementation, at least in adult patients with chron... | [
"erythropoiesis-stimulating agents",
"iron supplementation",
"iron status",
"inflammation",
"infection"
] | [
"P",
"P",
"P",
"P",
"P"
] |
Diabetologia-3-1-1914292 | Advanced glycation end products cause increased CCN family and extracellular matrix gene expression in the diabetic rodent retina
| Aims/hypothesis Referred to as CCN, the family of growth factors consisting of cystein-rich protein 61 (CYR61, also known as CCN1), connective tissue growth factor (CTGF, also known as CCN2), nephroblastoma overexpressed gene (NOV, also known as CCN3) and WNT1-inducible signalling pathway proteins 1, 2 and 3 (WISP1, −2... | [
"advanced glycation end products",
"extracellular matrix",
"cystein-rich protein 61",
"connective tissue growth factor",
"diabetic retinopathy",
"basement membrane",
"experimental",
"aminoguanidine",
"diabetes mellitus",
"gene expression regulation"
] | [
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"M",
"R"
] |
Histochem_Cell_Biol-4-1-2386530 | Structure and function of mammalian cilia
| In the past half century, beginning with electron microscopic studies of 9 + 2 motile and 9 + 0 primary cilia, novel insights have been obtained regarding the structure and function of mammalian cilia. All cilia can now be viewed as sensory cellular antennae that coordinate a large number of cellular signaling pathways... | [
"motility",
"primary cilia",
"signaling",
"motile cilia",
"ciliopathies",
"sensory organelles"
] | [
"P",
"P",
"P",
"P",
"P",
"R"
] |
Diabetologia-4-1-2270365 | Joint effects of HLA, INS, PTPN22 and CTLA4 genes on the risk of type 1 diabetes
| Background/hypothesis HLA, INS, PTPN22 and CTLA4 are considered to be confirmed type 1 diabetes susceptibility genes. HLA, PTPN22 and CTLA4 are known to be involved in immune regulation. Few studies have systematically investigated the joint effect of multiple genetic variants. We evaluated joint effects of the four es... | [
"ins",
"hla",
"ptpn22",
"ctla4",
"genes",
"type 1 diabetes",
"interaction"
] | [
"P",
"P",
"P",
"P",
"P",
"P",
"P"
] |
J_Comp_Physiol_A_Neuroethol_Sens_Neural_Behav_Physiol-4-1-2323032 | Mechanics of the exceptional anuran ear
| The anuran ear is frequently used for studying fundamental properties of vertebrate auditory systems. This is due to its unique anatomical features, most prominently the lack of a basilar membrane and the presence of two dedicated acoustic end organs, the basilar papilla and the amphibian papilla. Our current anatomica... | [
"anuran",
"auditory system",
"amphibian",
"frog",
"inner ear mechanics"
] | [
"P",
"P",
"P",
"P",
"P"
] |
Eur_J_Appl_Physiol-4-1-2267484 | Modulation in voluntary neural drive in relation to muscle soreness
| The aim of this study was to investigate whether (1) spinal modulation would change after non-exhausting eccentric exercise of the plantar flexor muscles that produced muscle soreness and (2) central modulation of the motor command would be linked to the development of muscle soreness. Ten healthy subjects volunteered ... | [
"eccentric",
"exercise",
"neuromuscular",
"doms",
"central fatigue"
] | [
"P",
"P",
"P",
"P",
"P"
] |
Ann_Surg_Oncol-3-1-2039838 | A Comparison Between Radioimmunotherapy and Hyperthermic Intraperitoneal Chemotherapy for the Treatment of Peritoneal Carcinomatosis of Colonic Origin in Rats
| Background Cytoreductive surgery (CS) followed by heated intraperitoneal chemotherapy (HIPEC) is considered the standard of care for the treatment of patients with peritoneal carcinomatosis (PC) of colorectal cancer (CRC). These surgical procedures result in a median survival of 2 years at the cost of considerable morb... | [
"radioimmunotherapy",
"peritoneal carcinomatosis",
"cytoreductive surgery",
"heated intraperitoneal chemotherapy",
"adjuvant",
"colon cancer"
] | [
"P",
"P",
"P",
"P",
"P",
"P"
] |
Int_J_Colorectal_Dis-4-1-2386750 | Surgical and pathological outcomes of laparoscopic surgery for transverse colon cancer
| Purpose Several multi-institutional prospective randomized trials have demonstrated short-term benefits using laparoscopy. Now the laparoscopic approach is accepted as an alternative to open surgery for colon cancer. However, in prior trials, the transverse colon was excluded. Therefore, it has not been determined whet... | [
"transverse colon",
"colon cancer",
"laparoscopy"
] | [
"P",
"P",
"P"
] |
Biochem_Biophys_Res_Commun-1-5-1899526 | An outwardly rectifying anionic background current in atrial myocytes from the human heart
| This report describes a hitherto unreported anionic background current from human atrial cardiomyocytes. Under whole-cell patch-clamp with anion-selective conditions, an outwardly rectifying anion current (IANION) was observed, which was larger with iodide than nitrate, and with nitrate than chloride as charge carrier.... | [
"anion",
"anion",
"background current",
"atrial myocyte",
"heart",
"patch-clamp",
"action potential",
"cardiac",
"atrium",
"anionic",
"computer modelling"
] | [
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"R"
] |
Psychopharmacologia-4-1-2270918 | Acute neuropsychological effects of MDMA and ethanol (co-)administration in healthy volunteers
| Rationale In Western societies, a considerable percentage of young people expose themselves to 3,4-methylenedioxymethamphetamine (MDMA or “ecstasy”). Commonly, ecstasy is used in combination with other substances, in particular alcohol (ethanol). MDMA induces both arousing as well as hallucinogenic effects, whereas eth... | [
"acute",
"neuropsychologic",
"effects",
"mdma",
"ethanol",
"healthy volunteers",
"ecstasy",
"alcohol",
"interaction"
] | [
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"P"
] |
Eur_J_Clin_Pharmacol-4-1-2426926 | Efficacy and safety of disodium ascorbyl phytostanol phosphates in men with moderate dyslipidemia
| Objective This study investigated the efficacy, safety, tolerability, and pharmacokinetics of a novel cholesterol absorption inhibitor, FM-VP4, comprising disodium ascorbyl sitostanol phosphate (DASP) and disodium ascorbyl campestanol phosphate (DACP).
Introduction
Worldwide, cardiovascular disease (CVD) is the most co... | [
"safety",
"pharmacokinetics",
"fm-vp4",
"plant sterols",
"hypercholesterolemia"
] | [
"P",
"P",
"P",
"P",
"U"
] |
Invert_Neurosci-4-1-2413115 | Crystal structures of Lymnaea stagnalis AChBP in complex with neonicotinoid insecticides imidacloprid and clothianidin
| Neonicotinoid insecticides, which act on nicotinic acetylcholine receptors (nAChRs) in a variety of ways, have extremely low mammalian toxicity, yet the molecular basis of such actions is poorly understood. To elucidate the molecular basis for nAChR–neonicotinoid interactions, a surrogate protein, acetylcholine binding... | [
"crystal structures",
"neonicotinoids",
"nicotinic acetylcholine receptors",
"ion channels",
"acetylcholine binding protein (lymnaea stagnalis)"
] | [
"P",
"P",
"P",
"P",
"R"
] |
Environ_Manage-2-2-1705480 | Multiscale Drivers of Water Chemistry of Boreal Lakes and Streams
| The variability in surface water chemistry within and between aquatic ecosystems is regulated by many factors operating at several spatial and temporal scales. The importance of geographic, regional-, and local-scale factors as drivers of the natural variability of three water chemistry variables representing buffering... | [
"anc",
"total phosphorus",
"toc",
"geographic position",
"spatial scale",
"variation partitioning",
"partial rda",
"lentic",
"lotic"
] | [
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"U",
"U"
] |
Knee_Surg_Sports_Traumatol_Arthrosc-4-1-2226194 | Does ligament balancing technique affect kinematics in rotating platform, PCL retaining knee arthroplasties?
| The goal of this prospective, randomized, blinded trial was to determine if ligament balancing techniques for rotating platform TKA affect postoperative knee kinematics. Sixteen patients with unilateral rotating platform TKA consented to participate in this institutional review board approved study. Eight patients were... | [
"rotating platform",
"tka",
"knee kinematics",
"spreader balancing device",
"soft tissue balancing",
"randomized control trial"
] | [
"P",
"P",
"P",
"R",
"R",
"R"
] |
Dig_Dis_Sci-3-1-2140097 | Twenty-Four Hour Tonometry in Patients Suspected of Chronic Gastrointestinal Ischemia
| Background and aims Gastrointestinal tonometry is currently the only clinical diagnostic test that enables identification of symptomatic chronic gastrointestinal ischemia. Gastric exercise tonometry has proven its value for detection of ischemia in this patients group, but has its disadvantages. Earlier studies with po... | [
"splanchnic stenosis",
"carbon dioxide",
"chronic splanchnic syndrome",
"chronic mesenteric ischemia",
"gastric tonometry",
"small bowel tonometry"
] | [
"P",
"P",
"M",
"R",
"R",
"M"
] |
Neurosurg_Rev-4-1-2279160 | Pure endoscopic endonasal odontoidectomy: anatomical study
| Different disorders may produce irreducible atlanto-axial dislocation with compression of the ventral spinal cord. Among the surgical approaches available for a such condition, the transoral resection of the odontoid process is the most often used. The aim of this anatomical study is to demonstrate the possibility of a... | [
"odontoid process",
"cranio-vertebral junction",
"endoscopy"
] | [
"P",
"P",
"U"
] |
Exp_Neurol-2-1-2288636 | Effects of low-frequency stimulation of the subthalamic nucleus on movement in Parkinson's disease
| Excessive synchronization of basal ganglia neural activity at low frequencies is considered a hallmark of Parkinson's disease (PD). However, few studies have unambiguously linked this activity to movement impairment through direct stimulation of basal ganglia targets at low frequency. Furthermore, these studies have va... | [
"parkinson's disease",
"synchronization",
"basal ganglia",
"dbs"
] | [
"P",
"P",
"P",
"P"
] |
Arthritis_Res_Ther-5-3-165040 | Degeneration of the intervertebral disc
| The intervertebral disc is a cartilaginous structure that resembles articular cartilage in its biochemistry, but morphologically it is clearly different. It shows degenerative and ageing changes earlier than does any other connective tissue in the body. It is believed to be important clinically because there is an asso... | [
"back pain",
"genetics",
"epidemiology"
] | [
"P",
"P",
"P"
] |
Eur_J_Pediatr-3-1-2042511 | What’s new in using platelet research? To unravel thrombopathies and other human disorders
| This review on platelet research focuses on defects of adhesion, cytoskeletal organisation, signal transduction and secretion. Platelet defects can be studied by different laboratory platelet functional assays and morphological studies. Easy bruising or a suspected platelet-based bleeding disorder is of course the most... | [
"platelets",
"adhesion",
"secretion",
"g protein signalling",
"cytoskeleton"
] | [
"P",
"P",
"P",
"P",
"P"
] |
Int_Arch_Occup_Environ_Health-4-1-2175021 | Coping and sickness absence
| Objectives The aim of this study is to examine the role of coping styles in sickness absence. In line with findings that contrast the reactive–passive focused strategies, problem-solving strategies are generally associated with positive results in terms of well-being and overall health outcomes; our hypothesis is that ... | [
"coping",
"sickness absence",
"frequency",
"length",
"duration",
"ucl"
] | [
"P",
"P",
"P",
"P",
"P",
"P"
] |
J_Autism_Dev_Disord-4-1-2226079 | Brief Report: Normal Intestinal Permeability at Elevated Platelet Serotonin Levels in a Subgroup of Children with Pervasive Developmental Disorders in Curaçao (The Netherlands Antilles)
| This study investigated the relationship between platelet (PLT) serotonin (5-HT) and intestinal permeability in children with pervasive developmental disorders (PDD). Differential sugar absorption and PLT 5-HT were determined in 23 children with PDD. PLT 5-HT (2.0–7.1 nmol/109 PLT) was elevated in 4/23 patients. None e... | [
"permeability",
"platelets",
"serotonin",
"pervasive",
"gastrointestinal",
"child development disorders"
] | [
"P",
"P",
"P",
"P",
"P",
"M"
] |
Appl_Microbiol_Biotechnol-3-1-2043089 | Assessment of technological options and economical feasibility for cyanophycin biopolymer and high-value amino acid production
| Major transitions can be expected within the next few decades aiming at the reduction of pollution and global warming and at energy saving measures. For these purposes, new sustainable biorefinery concepts will be needed that will replace the traditional mineral oil-based synthesis of specialty and bulk chemicals. An i... | [
"cyanophycin",
"biorefinery",
"bulk chemicals",
"n-functionality",
"protamylasse",
"non-ribosomal",
"plant waste, rest stream"
] | [
"P",
"P",
"P",
"P",
"P",
"P",
"R"
] |
Knee_Surg_Sports_Traumatol_Arthrosc-3-1-2042026 | Analysis of Oxford medial unicompartmental knee replacement using the minimally invasive technique in patients aged 60 and above: an independent prospective series
| We present the outcome of an independent prospective series of phase-3 Oxford medial mobile-bearing unicompartmental knee replacement surgery. Eight surgeons performed the 154 procedures in a community-based hospital between 1998 and 2003 for patients aged 60 and above. Seventeen knees were revised; in 14 cases a total... | [
"unicompartmental",
"knee",
"replacement",
"mobile bearing"
] | [
"P",
"P",
"P",
"R"
] |
Purinergic_Signal-3-4-2072925 | New insights into purinergic receptor signaling in neuronal differentiation, neuroprotection, and brain disorders
| Ionotropic P2X and metabotropic P2Y purinergic receptors are expressed in the central nervous system and participate in the synaptic process particularly associated with acetylcholine, GABA, and glutamate neurotransmission. As a result of activation, the P2 receptors promote the elevation of free intracellular calcium ... | [
"knockout animal",
"atp",
"neurotransmitter",
"neural stem cells",
"p19 embryonal carcinoma cells"
] | [
"P",
"P",
"P",
"P",
"R"
] |
Ann_Hematol-3-1-1914243 | CD34-related coexpression of MDR1 and BCRP indicates a clinically resistant phenotype in patients with acute myeloid leukemia (AML) of older age
| Clinical resistance to chemotherapy in acute myeloid leukemia (AML) is associated with the expression of the multidrug resistance (MDR) proteins P-glycoprotein, encoded by the MDR1/ABCB1 gene, multidrug resistant-related protein (MRP/ABCC1), the lung resistance-related protein (LRP), or major vault protein (MVP), and t... | [
"mdr1",
"bcrp",
"genes",
"lrp",
"mrp1",
"elderly aml"
] | [
"P",
"P",
"P",
"P",
"P",
"P"
] |
Qual_Life_Res-4-1-2238788 | Effectiveness of health-related quality-of-life measurement in clinical practice: a prospective, randomized controlled trial in patients with chronic liver disease and their physicians
| Background This study assessed the effectiveness of computerized measurement and feedback of health-related quality of life (HRQoL) in daily clinical practice in patients with chronic liver disease.
Introduction
Health-related quality of life (HRQoL), or psychological, social, and physical functioning [1], has become a... | [
"liver",
"quality of life",
"hepatology",
"implementation"
] | [
"P",
"P",
"P",
"P"
] |
Purinergic_Signal-3-4-2072922 | Adenosine A1 receptor: Functional receptor-receptor interactions in the brain
| Over the past decade, many lines of investigation have shown that receptor-mediated signaling exhibits greater diversity than previously appreciated. Signal diversity arises from numerous factors, which include the formation of receptor dimers and interplay between different receptors. Using adenosine A1 receptors as a... | [
"adenosine",
"receptor interactions",
"g protein-coupled receptors",
"ionotropic receptors",
"adenosine receptors",
"neurotransmission"
] | [
"P",
"P",
"P",
"P",
"P",
"P"
] |
Biotechnol_Lett-3-1-1914260 | Expression of alternansucrase in potato plants
| Alternan, which consists of alternating α-(1→3)/α-(1→6)-linked glucosyl residues, was produced in potato tubers by expressing a mature alternansucrase (Asr) gene from Leuconostoc mesenteroides NRRL B-1355 in potato. Detection of alternan was performed by enzyme-linked immunosorbent assay in tuber juices, revealing a co... | [
"alternan",
"transgenic potato",
"glucansucrase",
"polymer solubility"
] | [
"P",
"P",
"P",
"P"
] |
Qual_Life_Res-3-1-2039822 | Reliability and validity of functional health status and health-related quality of life questionnaires in children with recurrent acute otitis media
| In this study the reliability and validity of generic and disease-specific questionnaires has been assessed focusing on responsiveness. This is part of a study on the effects of recurrent acute otitis media (rAOM) on functional health status (FHS) and health-related quality of life (HRQoL) in 383 children with rAOM par... | [
"reliability",
"validity",
"functional health status",
"quality of life",
"acute otitis media",
"responsiveness",
"childhood infection"
] | [
"P",
"P",
"P",
"P",
"P",
"P",
"P"
] |
Purinergic_Signal-3-4-2072921 | Mapping P2X and P2Y receptor proteins in striatum and substantia nigra: An immunohistological study
| Our work aimed to provide a topographical analysis of all known ionotropic P2X1–7 and metabotropic P2Y1,2,4,6,11–14 receptors that are present in vivo at the protein level in the basal ganglia nuclei and particularly in rat brain slices from striatum and substantia nigra. By immunohistochemistry-confocal and Western bl... | [
"rat brain",
"tyrosine hydroxylase",
"6-hydroxydopamine",
"parkinson’s disease",
"purinergic receptors",
"γ-aminobutyric acid"
] | [
"P",
"P",
"P",
"P",
"P",
"M"
] |
Diabetologia-4-1-2270360 | Best practice guidelines for the molecular genetic diagnosis of maturity-onset diabetes of the young
| Aims/hypothesis Mutations in the GCK and HNF1A genes are the most common cause of the monogenic forms of diabetes known as ‘maturity-onset diabetes of the young’. GCK encodes the glucokinase enzyme, which acts as the pancreatic glucose sensor, and mutations result in stable, mild fasting hyperglycaemia. A progressive i... | [
"best practice",
"maturity-onset diabetes of the young",
"gck",
"hnf1a",
"hnf4a",
"mody",
"monogenic diabetes"
] | [
"P",
"P",
"P",
"P",
"P",
"P",
"P"
] |
Intensive_Care_Med-4-1-2228379 | Short-term beneficial effects of methylene blue on kidney damage in septic shock patients
| Objective We previously demonstrated that upregulation of renal inducible nitric oxide synthase (iNOS) is associated with proximal tubule injury during systemic inflammation in humans. In this study we investigated the short-term effect of methylene blue (MB), an inhibitor of the NO pathway, on kidney damage and functi... | [
"acute kidney injury",
"glutathione s-transferase",
"inducible nitric oxide synthase expression",
"nitric oxide metabolites"
] | [
"P",
"P",
"R",
"R"
] |
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