id stringlengths 16 65 | title stringlengths 19 278 | text stringlengths 894 136k | keyphrases listlengths 1 34 | prmu listlengths 1 34 |
|---|---|---|---|---|
Purinergic_Signal-3-4-2072928 | Involvement of P2X and P2Y receptors in microglial activation in vivo
| Microglial cells are the primary immune effector cells in the brain. Extracellular ATP, e.g., released after brain injury, may initiate microglial activation via stimulation of purinergic receptors. In the rat nucleus accumbens (NAc), the involvement of P2X and P2Y receptors in the generation of microglial reaction in ... | [
"injury",
"p2 receptors",
"microglia",
"cns",
"trauma"
] | [
"P",
"P",
"P",
"U",
"U"
] |
J_Mol_Med-3-1-2121654 | Modulation of muscle contraction by a cell-permeable peptide
| In contrast to immortal cell lines, primary cells are hardly susceptible to intracellular delivery methods such as transfection. In this study, we evaluated the direct delivery of several cell-permeable peptides under noninvasive conditions into living primary adult rat cardiomyocytes. We specifically monitored the fun... | [
"cardiomyocytes",
"ventricular light chain-1 (vlc-1)",
"peptide transduction",
"cell penetrating peptide (cpp)",
"drug delivery"
] | [
"P",
"P",
"P",
"R",
"R"
] |
Eur_J_Appl_Physiol-4-1-2226001 | Identification of elderly fallers by muscle strength measures
| For efficient prevention of falls among older adults, individuals at a high risk of falling need to be identified. In this study, we searched for muscle strength measures that best identified those individuals who would fall after a gait perturbation and those who recovered their balance. Seventeen healthy older adults... | [
"perturbation",
"classification",
"ageing",
"fall risk",
"physical capacity"
] | [
"P",
"P",
"P",
"P",
"M"
] |
Eur_Spine_J-4-1-2226193 | Clinical effect of continuous corrective force delivery in the non-operative treatment of idiopathic scoliosis: a prospective cohort study of the triac-brace
| A prospective cohort study of skeletally immature idiopathic scoliotic patients treated with the TriaC brace. To determine if the TriaC brace is effective in preventing curve progression in immature adolescent idiopathic scoliotic patients with a very high risk of curve progression based on reported natural history dat... | [
"scoliosis",
"bracing",
"natural history",
"biomechanics"
] | [
"P",
"P",
"P",
"P"
] |
Eur_J_Nucl_Med_Mol_Imaging-4-1-2100432 | Functional sex differences in human primary auditory cortex
| Background We used PET to study cortical activation during auditory stimulation and found sex differences in the human primary auditory cortex (PAC). Regional cerebral blood flow (rCBF) was measured in 10 male and 10 female volunteers while listening to sounds (music or white noise) and during a baseline (no auditory s... | [
"pet",
"brain",
"neuroimaging",
"hearing",
"gender"
] | [
"P",
"P",
"P",
"P",
"U"
] |
Purinergic_Signal-4-2-2377316 | GTP avoidance in Tetrahymena thermophila requires tyrosine kinase activity, intracellular calcium, NOS, and guanylyl cyclase
| Guanosine 5'-triphosphate (GTP) is a chemorepellent in Tetrahymena thermophila that has been shown to stimulate cell division as well as ciliary reversal. Previous studies have proposed that GTP avoidance is linked to a receptor-mediated, calcium-based depolarization. However, the intracellular mechanisms involved in G... | [
"chemorepellent",
"extracellular nucleotide",
"purine metabolism"
] | [
"P",
"R",
"R"
] |
Ann_Surg_Oncol-3-1-1914276 | Pathological and Biological Differences Between Screen-Detected and Interval Ductal Carcinoma in situ of the Breast
| Background The incidence of ductal carcinoma in situ (DCIS) has risen dramatically with the introduction of screening mammography. The aim was to evaluate differences in pathological and biological characteristics between patients with screen-detected and interval DCIS.
With the introduction of widespread screening mam... | [
"screening",
"ductal carcinoma in situ",
"immunohistochemistry",
"biological markers",
"breast neoplasm"
] | [
"P",
"P",
"P",
"P",
"M"
] |
Eur_J_Pediatr-4-1-2234442 | Mucopolysaccharidosis type II (Hunter syndrome): a clinical review and recommendations for treatment in the era of enzyme replacement therapy
| Mucopolysaccharidosis type II (MPS II; Hunter syndrome) is a rare X-linked recessive disease caused by deficiency of the lysosomal enzyme iduronate-2-sulphatase, leading to progressive accumulation of glycosaminoglycans in nearly all cell types, tissues and organs. Clinical manifestations include severe airway obstruct... | [
"mucopolysaccharidosis type ii",
"hunter syndrome",
"enzyme replacement therapy",
"idursulfase",
"treatment recommendations"
] | [
"P",
"P",
"P",
"P",
"R"
] |
Breast_Cancer_Res_Treat-3-1-2001219 | Letrozole in advanced breast cancer: the PO25 trial
| Tamoxifen has been a standard first-line endocrine therapy for post-menopausal women with hormone-responsive advanced breast cancer, but more than half of patients fail to respond and time to progression is less than 12 months in responders. The third-generation aromatase inhibitors were developed to provide more effec... | [
"letrozole",
"advanced breast cancer",
"tamoxifen",
"aromatase inhibitors",
"postmenopausal"
] | [
"P",
"P",
"P",
"P",
"U"
] |
Matern_Child_Health_J-2-2-1592157 | Prevalence of Risk Factors for Adverse Pregnancy Outcomes During Pregnancy and the Preconception Period—United States, 2002–2004
| Objectives: To assess the prevalence of risk factors for adverse pregnancy outcome during the preconception stage and during pregnancy, and to assess differences between women in preconception and pregnancy. Methods: Data from the 2002 and 2004 Behavioral Risk Factor Surveillance System, United States, were used to est... | [
"pregnancy",
"preconception",
"riskfactors"
] | [
"P",
"P",
"U"
] |
Dev_Genes_Evol-4-1-2265772 | Glutamine synthetase gene expression during the regeneration of the annelid Enchytraeus japonensis
| Enchytraeus japonensis is a highly regenerative oligochaete annelid that can regenerate a complete individual from a small body fragment in 4–5 days. In our previous study, we performed complementary deoxyribonucleic acid subtraction cloning to isolate genes that are upregulated during E. japonensis regeneration and id... | [
"glutamine synthetase",
"gene expression",
"regeneration",
"enchytraeus japonensis",
"oligochaete annelid"
] | [
"P",
"P",
"P",
"P",
"P"
] |
Clin_Rheumatol-4-1-2367388 | Antioxidant intervention in rheumatoid arthritis: results of an open pilot study
| There is evidence that reactive oxygen species play a causal role in auto-immune diseases, such as rheumatoid arthritis (RA). Despite the supporting evidence for a beneficial effect of antioxidants on clinical characteristics of RA, the right balance for optimal effectiveness of antioxidants is largely unknown. To dete... | [
"antioxidants",
"intervention",
"rheumatoid arthritis",
"clinical parameters"
] | [
"P",
"P",
"P",
"P"
] |
Mcgill_J_Med-11-1-2322926 | Anterior cruciate ligament reconstruction: a look at prosthetics - past, present and possible future
| Biological tissue autograft reconstruction using the patellar tendon or quadrupled semitendinosus/gracilis tendons has become the most popular procedure in surgical treatment of a ruptured ACL. This article provides a review of the history of the use of prosthetics with respect to ACL reconstruction grafts including Ca... | [
"anterior cruciate ligament",
"prosthetics",
"tissue engineering",
"biomaterials",
"synthetic grafts"
] | [
"P",
"P",
"P",
"P",
"R"
] |
Eur_J_Appl_Physiol-3-1-2039775 | Distribution of motor unit potential velocities in short static and prolonged dynamic contractions at low forces: use of the within-subject’s skewness and standard deviation variables
| Behaviour of motor unit potential (MUP) velocities in relation to (low) force and duration was investigated in biceps brachii muscle using a surface electrode array. Short static tests of 3.8 s (41 subjects) and prolonged dynamic tests (prolonged tests) of 4 min (30 subjects) were performed as position tasks, applying ... | [
"motor unit potential",
"dynamic contraction",
"skewness",
"position task",
"surface electromyography",
"conduction velocity distribution"
] | [
"P",
"P",
"P",
"P",
"P",
"R"
] |
J_Abnorm_Child_Psychol-3-1-1915644 | Multiple Determinants of Externalizing Behavior in 5-Year-Olds: A Longitudinal Model
| In a community sample of 116 children, assessments of parent-child interaction, parent-child attachment, and various parental, child, and contextual characteristics at 15 and 28 months and at age 5 were used to predict externalizing behavior at age 5, as rated by parents and teachers. Hierarchical multiple regression a... | [
"externalizing behavior",
"longitudinal model",
"parent-child interaction",
"disorganized attachment",
"early predictors"
] | [
"P",
"P",
"P",
"P",
"P"
] |
Eur_Radiol-4-1-2270369 | Prevalence of anatomical variants and coronary anomalies in 543 consecutive patients studied with 64-slice CT coronary angiography
| The aim of our study was to assess the prevalence of variants and anomalies of the coronary artery tree in patients who underwent 64-slice computed tomography coronary angiography (CT-CA) for suspected or known coronary artery disease. A total of 543 patients (389 male, mean age 60.5 ± 10.9) were reviewed for coronary ... | [
"anatomical variants",
"anomalies",
"multislice computed tomography",
"coronary artery circulation"
] | [
"P",
"P",
"P",
"M"
] |
Pediatr_Nephrol-4-1-2335291 | Treatment of the neurogenic bladder in spina bifida
| Renal damage and renal failure are among the most severe complications of spina bifida. Over the past decades, a comprehensive treatment strategy has been applied that results in minimal renal scaring. In addition, the majority of patients can be dry for urine by the time they go to primary school. To obtain such resul... | [
"spina bifida",
"incontinence",
"renal function",
"dryness",
"antimuscarinic",
"bladder augmentation",
"surgical treatment",
"bladder-neck sling"
] | [
"P",
"P",
"P",
"P",
"P",
"P",
"R",
"R"
] |
J_Med_Internet_Res-1-suppl1-1761819 | SYD1/444: Assessing the Readership of the UK National Database of Telemedicine
| Introduction The National Database of Telemedicine (NDTM) is a Web site containing information resources on UK telemedicine projects and related work. Its purpose is to provide a source of information to anyone researching the field or proposing a trial or a larger scale implementation of Telemedicine. The NDTM Web sit... | [
"telemedicine",
"internet",
"hypermedia",
"readership analysis"
] | [
"P",
"U",
"U",
"M"
] |
Intensive_Care_Med-3-1-2040486 | The first demonstration of lactic acid in human blood in shock by Johann Joseph Scherer (1814–1869) in January 1843
| Lactic acid was first found and described in sour milk by Karl Wilhelm Scheele (1742–1786) in 1780. The German physician–chemist Johann Joseph Scherer (1841–1869) demonstrated the occurrence of lactic acid in human blood under pathological conditions in 1843 and 1851. In this article we honour the forgotten observation... | [
"lactic acid",
"shock",
"johann joseph scherer",
"lactate",
"leukaemia",
"historical article"
] | [
"P",
"P",
"P",
"P",
"P",
"M"
] |
Anal_Bioanal_Chem-4-1-2287205 | Reversed-phase liquid chromatography coupled on-line to estrogen receptor bioaffinity detection based on fluorescence polarization
| We describe the development and validation of a high-resolution screening (HRS) platform which couples gradient reversed-phase high-performance liquid chromatography (RP-HPLC) on-line to estrogen receptor α (ERα) affinity detection using fluorescence polarization (FP). FP, which allows detection at high wavelengths, li... | [
"fluorescence polarization",
"high-resolution screening (hrs)",
"estrogen receptor α",
"phytoestrogens",
"receptor affinity detection (rad)",
"on-line bioaffinity assay"
] | [
"P",
"P",
"P",
"P",
"P",
"R"
] |
Obes_Surg-4-1-2226018 | Psychosocial Functioning, Personality, and Body Image Following Vertical Banded Gastroplasty
| Background In addition to increased risks of morbidity and mortality, extreme obesity is substantially associated with psychosocial problems. Therefore, the ultimate goal of bariatric surgery should not only be reducing weight and counteracting comorbid conditions but also improving psychosocial functioning. In additio... | [
"psychosocial functioning",
"personality",
"body image",
"vertical banded gastroplasty",
"bariatric surgery",
"psychopathology",
"morbid obesity"
] | [
"P",
"P",
"P",
"P",
"P",
"P",
"R"
] |
Osteoporos_Int-3-1-1820757 | Links between cardiovascular disease and osteoporosis in postmenopausal women: serum lipids or atherosclerosis per se?
| Introduction and hypothesis Epidemiological observations suggest links between osteoporosis and risk of acute cardiovascular events and vice versa. Whether the two clinical conditions are linked by common pathogenic factors or atherosclerosis per se remains incompletely understood. We investigated whether serum lipids ... | [
"osteoporosis",
"lipids",
"cardiovascular events",
"aorta calcification",
"apoe polymorphism"
] | [
"P",
"P",
"P",
"P",
"P"
] |
J_Neurol-3-1-1915648 | Does modafinil enhance activity of patients with myotonic dystrophy?
| We performed a double-blind placebo-controlled crossover study in 13 patients with myotonic dystrophy to address the question whether modafinil, known to improve hypersomnolence in myotonic dystrophy, may improve levels of activity as well. We used the Epworth Sleepiness Scale as a measure of hypersomnolence and a stru... | [
"modafinil",
"myotonic dystrophy",
"hypersomnolence",
"levels of activity",
"rand-36"
] | [
"P",
"P",
"P",
"P",
"P"
] |
Antonie_Van_Leeuwenhoek-3-1-2140093 | Domain analysis of lipoprotein LppQ in Mycoplasma mycoides subsp. mycoides SC
| The lipoprotein LppQ is the most prominent antigen of Mycoplasma mycoides subsp. mycoides small colony type (SC) during infection of cattle. This pathogen causes contagious bovine pleuropneumonia (CBPP), a devastating disease of considerable socio-economic importance in many countries worldwide. The dominant antigenici... | [
"domain analysis",
"lipoprotein lppq",
"mycoplasma mycoides subsp. mycoides sc",
"contagious bovine pleuropneumonia (cbpp)",
"immunogold labeling",
"scanning electron microscopy (sem)"
] | [
"P",
"P",
"P",
"P",
"P",
"P"
] |
Doc_Ophthalmol-3-1-1896293 | ISCEV standard for clinical pattern electroretinography—2007 update
| The pattern electroretinogram (PERG) is a retinal response evoked by viewing a temporally alternating pattern, usually a black and white checkerboard or grating. The PERG is important in clinical and research applications because it provides information both about retinal ganglion cell function and, because the stimulu... | [
"pattern electroretinogram",
"electroretinogram",
"macula",
"clinical electrophysiology",
"retina"
] | [
"P",
"P",
"P",
"P",
"P"
] |
Anal_Bioanal_Chem-4-1-2045123 | A new highly specific and robust yeast androgen bioassay for the detection of agonists and antagonists
| Public concern about the presence of natural and anthropogenic compounds which affect human health by modulating normal endocrine functions is continuously growing. Fast and simple high-throughput screening methods for the detection of hormone activities are thus indispensable. During the last two decades, a panel of d... | [
"antagonists",
"receptor",
"metabolism",
"crosstalk",
"brominated flame retardants",
"saccharomyces cerevisiae"
] | [
"P",
"P",
"P",
"P",
"P",
"P"
] |
Anal_Bioanal_Chem-2-2-1764597 | Advances in analytical techniques for polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans and dioxin-like PCBs
| Analytical techniques for the determination of polychorinated dibenzo-p-dioxins (PCDD), polychlorinated dibenzofurans (PCDF) and dioxin-like PCBs (DLPCB) are reviewed. The focus of the review is on recent advances in methodology and analytical procedures. The paper also reviews toxicology, the development of toxic equi... | [
"polychlorinated dibenzofurans",
"dioxin-like pcbs",
"pcdd",
"pcdf",
"dlpcb",
"review",
"toxicity",
"environmental levels",
"analysis",
"extraction",
"mass spectrometry",
"sample preparation",
"polychlorinated dibenzo-p-dioxins"
] | [
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"R"
] |
Clin_Auton_Res-3-1-1797061 | Diversity of sympathetic vasoconstrictor pathways and their plasticity after spinal cord injury
| Sympathetic vasoconstrictor pathways pass through paravertebral ganglia carrying ongoing and reflex activity arising within the central nervous system to their vascular targets. The pattern of reflex activity is selective for particular vascular beds and appropriate for the physiological outcome (vasoconstriction or va... | [
"vasoconstriction",
"sympathetic nervous system",
"sympathetic ganglia",
"autonomic dysreflexia",
"norepineph- rine",
"autonomic nervous system"
] | [
"P",
"P",
"P",
"P",
"U",
"R"
] |
Soc_Psychiatry_Psychiatr_Epidemiol-3-1-2039804 | Prevalence and predictors of health service use among Iraqi asylum seekers in the Netherlands
| Background A long asylum procedure is associated with higher prevalence rates of psychiatric disorders, lower quality of life, higher disability and more physical health problems. Additional knowledge about health seeking behavior is necessary to guide governments and health professionals in their policies.
Introductio... | [
"service use",
"iraq",
"asylum seekers",
"psychiatric disorders",
"drug consumption"
] | [
"P",
"P",
"P",
"P",
"P"
] |
Ann_Hematol-4-1-2324130 | Immunoglobulin and free light chain abnormalities in Gaucher disease type I: data from an adult cohort of 63 patients and review of the literature
| Gaucher disease type I, the most common lysosomal storage disorder, is associated with immunoglobulin abnormalities. We studied the prevalence, risk factors, pathogenesis, and effect of enzyme relation therapy (ERT) on gammopathies in an adult Gaucher disease type I cohort (N = 63) and related the results to a review o... | [
"free light chains",
"gaucher disease",
"mgus",
"multiple myeloma",
"cytokines"
] | [
"P",
"P",
"P",
"P",
"P"
] |
Cancer_Causes_Control-2-2-1705538 | Breast cancer risk factors in relation to breast density (United States)
| Objectives Evaluate known breast cancer risk factors in relation to breast density.
Introduction
Numerous studies have shown that breast density, as assessed through mammography, is an important breast cancer risk factor [1–5]. Relative to the lowest classification of breast density (fatty tissue), women with the highe... | [
"hormone replacement therapy",
"reproductive history",
"mammographic breast density"
] | [
"P",
"R",
"R"
] |
Graefes_Arch_Clin_Exp_Ophthalmol-4-1-2367393 | Posterior capsulorhexis combined with optic buttonholing: an alternative to standard in-the-bag implantation of sharp-edged intraocular lenses? A critical analysis of 1000 consecutive cases
| Background Current after-cataract prevention relies on optimizing the natural barrier effect of the optic rim against lens epithelial cell (LEC) migration. However, deficiencies in circumferential capsular bag closure caused by the intraocular lens (IOL) haptic or delayed secondary re-division of the fused capsules by ... | [
"optic buttonholing",
"posterior capsule opacification",
"fibrosis",
"regeneratory after-cataract",
"reclosure",
"primary posterior capsulorhexis",
"cystoid macular edema",
"retinal detachment",
"vitreous entrapment",
"toric iols",
"iop",
"flare",
"axial optic shift",
"optic centration"
] | [
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"U",
"U",
"R",
"R"
] |
Psychopharmacologia-4-1-2244695 | Selective PDE inhibitors rolipram and sildenafil improve object retrieval performance in adult cynomolgus macaques
| Rationale Selective phosphodiesterase (PDE) inhibitors improve the formation of hippocampus-dependent memories in several rodent models of cognition. However, studies evaluating the effects of PDE inhibition on prefrontal cortex-dependent cognition and in monkeys are rare.
Introduction
Second messenger cyclic nucleotid... | [
"rolipram",
"sildenafil",
"object retrieval",
"phosphodiesterase",
"cognition",
"monkey",
"pde4",
"pde5",
"attention",
"executive function",
"primate",
"cyclic amp",
"cyclic gmp"
] | [
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"M",
"M"
] |
Behav_Genet-4-1-2257997 | Speed, Variability, and Timing of Motor Output in ADHD: Which Measures are Useful for Endophenotypic Research?
| Attention-Deficit/Hyperactivity Disorder (ADHD) shares a genetic basis with motor coordination problems and probably motor timing problems. In line with this, comparable problems in motor timing should be observed in first degree relatives and might, therefore, form a suitable endophenotypic candidate. This hypothesis ... | [
"adhd",
"endophenotype",
"motor timing",
"siblings",
"motor speed",
"motor variability"
] | [
"P",
"P",
"P",
"P",
"P",
"R"
] |
Biotechnol_Lett-3-1-2045120 | Solute transport in orthorhombic lysozyme crystals: a molecular simulation study
| Long-time equilibrium molecular dynamics simulations were performed to study the passage of a substrate, l-arabinose, through nanopores of orthorhombic hen egg white lysozyme crystals. Cross-linked protein crystals (CLPC), as novel biological nanoporous media, consist of an extensive regular matrix of chiral solvent-fi... | [
"lysozyme",
"molecular dynamics",
"l-arabinose",
"protein crystal",
"diffusion"
] | [
"P",
"P",
"P",
"P",
"P"
] |
J_Mol_Med-4-1-2359832 | Analysis of human MDM4 variants in papillary thyroid carcinomas reveals new potential markers of cancer properties
| A wild-type (wt) p53 gene characterizes thyroid tumors, except for the rare anaplastic histotype. Because p53 inactivation is a prerequisite for tumor development, alterations of p53 regulators represent an alternative way to impair p53 function. Indeed, murine double minute 2 (MDM2), the main p53 negative regulator, i... | [
"mdm4",
"mdm4 variants",
"thyroid carcinoma",
"p53",
"mdm2"
] | [
"P",
"P",
"P",
"P",
"P"
] |
Histochem_Cell_Biol-3-1-1779629 | BAC constructs in transgenic reporter mouse lines control efficient and specific LacZ expression in hypertrophic chondrocytes under the complete Col10a1 promoter
| During endochondral ossification hypertrophic chondrocytes in the growth plate of fetal long bones, ribs and vertebrae play a key role in preparing growth plate cartilage for replacement by bone. In order to establish a reporter gene mouse to facilitate functional analysis of genes expressed in hypertrophic chondrocyte... | [
"bac",
"hypertrophic cartilage",
"homologous recombination",
"collagen x",
"transgenic mouse"
] | [
"P",
"P",
"P",
"P",
"P"
] |
Eur_J_Nucl_Med_Mol_Imaging-3-1-1998881 | ApoSense: a novel technology for functional molecular imaging of cell death in models of acute renal tubular necrosis
| Purpose Acute renal tubular necrosis (ATN), a common cause of acute renal failure, is a dynamic, rapidly evolving clinical condition associated with apoptotic and necrotic tubular cell death. Its early identification is critical, but current detection methods relying upon clinical assessment, such as kidney biopsy and ... | [
"apoptosis imaging",
"cell death detection",
"renal disease",
"renal uptake",
"small animal imaging"
] | [
"R",
"R",
"R",
"R",
"R"
] |
Psychopharmacologia-3-1-2048539 | Acute and constitutive increases in central serotonin levels reduce social play behaviour in peri-adolescent rats
| Rationale Serotonin is an important modulator of social behaviour. Individual differences in serotonergic signalling are considered to be a marker of personality that is stable throughout lifetime. While a large body of evidence indicates that central serotonin levels are inversely related to aggression and sexual beha... | [
"serotonin",
"social play",
"peri-adolescence",
"fluoxetine",
"knockout rat",
"mdma"
] | [
"P",
"P",
"P",
"P",
"P",
"P"
] |
J_Mol_Med-3-1-2121656 | Harnessing hypoxic adaptation to prevent, treat, and repair stroke
| The brain demands oxygen and glucose to fulfill its roles as the master regulator of body functions as diverse as bladder control and creative thinking. Chemical and electrical transmission in the nervous system is rapidly disrupted in stroke as a result of hypoxia and hypoglycemia. Despite being highly evolved in its ... | [
"stroke",
"brain",
"hypoxia",
"hif",
"therapeutics",
"hif prolyl hydroxylase"
] | [
"P",
"P",
"P",
"P",
"P",
"R"
] |
Environ_Health_Perspect-114-2-1367850 | Prenatal Methylmercury Exposure and Developmental Outcomes: Review of the Evidence and Discussion of Future Directions
| I conducted a review of the published literature to assess the strength of the evidence for an association between prenatal exposure to methylmercury (MeHg) and subsequent child development. I identified 12 studies on this subject published since 1980. Of these, 3 were longitudinal studies—2 conducted in the Seychelle ... | [
"methylmercury",
"developmental outcomes",
"prenatal exposure",
"neurobehavioral tests"
] | [
"P",
"P",
"P",
"P"
] |
J_Gastrointest_Surg-3-1-1852381 | Successful Internalization of a Chronic Biliary Cutaneous Fistula After Liver Transplantation: Deepithelializing the Fistula Tract
| Biliary cutaneous fistulas are uncommon sequelae after biliary surgery and can be a source of significant morbidity. We describe a liver recipient who developed a biliary cutaneous fistula secondary to hepatic artery thrombosis; this subsequently drained for over 7 years. Through a novel approach, using the transabdomi... | [
"liver transplantation",
"biliary fistula"
] | [
"P",
"P"
] |
J_Gastrointest_Surg-3-1-1852388 | Middle Segment Pancreatectomy: A Useful Tool in the Management of Pancreatic Neoplasms
| Small, benign, or low-grade malignant tumors located in the neck of the pancreas are usually treated with enucleation. However, if enucleation is too risky because of possible damage of the main pancreatic duct, standard pancreatic resections are performed. Such operations can lead to impaired long-term exocrine–endocr... | [
"middle segment pancreatectomy",
"pancreatic resection",
"pancreatic function",
"pancreatic tumors",
"surgical complications"
] | [
"P",
"P",
"P",
"R",
"R"
] |
Ann_Surg_Oncol-4-1-2277445 | Metinel Node—The First Lymph Node Draining a Metastasis—Contains Tumor-Reactive Lymphocytes
| Background We previously identified tumor-reactive lymphocytes in the first lymph nodes that drain the primary tumor. In this study, we performed lymphatic mapping to investigate the possibility of finding the first lymph nodes that drain metastases, and of learning whether these lymph nodes contained tumor-reactive ly... | [
"metastases",
"lymphatic mapping",
"immunotherapy",
"sentinel node",
"solid tumors"
] | [
"P",
"P",
"P",
"P",
"P"
] |
Eur_Arch_Otorhinolaryngol-3-1-2099162 | Tonsillar metastasis of oesophageal adenocarcinoma
| In the literature less than 100 cases of metastatic carcinoma of the palatine tonsil have been reported. Tonsillar metastasis of adenocarcinoma of the oesophagus has not been reported previously. We report a case of a 57-year-old male with a primary adenocarcinoma of the distal esophagus with a metastasis in the right ... | [
"tonsil",
"metastasis",
"adenocarcinoma",
"oesophagus",
"head and neck"
] | [
"P",
"P",
"P",
"P",
"P"
] |
Eur_J_Health_Econ-_-_-1388078 | Defining the “Health Benefit Basket” in nine European countries
| This article identifies and analyses a framework for “health baskets,” the taxonomy of benefit catalogues for curative services, and the criteria for the in- or exclusion of benefits in nine EU member states (Denmark, England, France, Germany, Hungary, Italy, The Netherlands, Poland and Spain). Focusing on services of ... | [
"health services",
"health benefit plans",
"health priorities",
"national health programs",
"insurance benefits"
] | [
"P",
"R",
"R",
"M",
"R"
] |
J_Fluoresc-3-1-1915606 | Sensitive Spectroscopic Detection of Large and Denatured Protein Aggregates in Solution by Use of the Fluorescent Dye Nile Red
| The fluorescent dye Nile red was used as a probe for the sensitive detection of large, denatured aggregates of the model protein β-galactosidase (E. coli) in solution. Aggregates were formed by irreversible heat denaturation of β-galactosidase below and above the protein’s unfolding temperature of 57.4°C, and the prese... | [
"protein aggregation",
"nile red",
"fluorescence correlation spectroscopy",
"size exclusion chromatography",
"fluorescence spectroscopy"
] | [
"P",
"P",
"P",
"P",
"P"
] |
Diabetologia-3-1-1914285 | Absence of an adipogenic effect of rosiglitazone on mature 3T3-L1 adipocytes: increase of lipid catabolism and reduction of adipokine expression
| Aims/hypothesis The thiazolidinedione (TZD) rosiglitazone is a peroxisome proliferator-activated receptor-γ agonist that induces adipocyte differentiation and, hence, lipid accumulation. This is in apparent contrast to the long-term glucose-lowering, insulin-sensitising effect of rosiglitazone. We tested whether the ac... | [
"adipokine",
"thiazolidinediones",
"mature adipocytes",
"adipose tissue",
"secretion",
"microarray",
"energy metabolism",
"lipogenesis",
"lipolysis"
] | [
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"P"
] |
Ann_Biomed_Eng-2-2-1705476 | Autonomous Reovirus Strain Classification Using Filament-Coupled Antibodies
| We previously described a filament-based antibody recognition assay (FARA) that generates ELISA-like sandwich structures immobilized on a filament. FARA allows the coupling of antibodies to precise locations along a filament, on-line fluorescence detection of captured pathogen, and feedback-directed filament motion. Th... | [
"fluorescence detection",
"pathogen detection",
"virus detection",
"virus classification"
] | [
"P",
"P",
"P",
"R"
] |
Diabetologia-3-1-2063563 | Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms
| Aims/hypothesis Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes and reduced insulin secretion. The transcription factor TCF7L2 is an essential factor for glucagon-like peptide-1 (GLP-1) secretion from intestinal L cells. We studied whether a defect in the enteroinsul... | [
"insulin secretion",
"tcf7l2",
"polymorphism",
"glp-1"
] | [
"P",
"P",
"P",
"P"
] |
Plant_Mol_Biol-4-1-2295253 | Interaction between sugar and abscisic acid signalling during early seedling development in Arabidopsis
| Sugars regulate important processes and affect the expression of many genes in plants. Characterization of Arabidopsis (Arabidopsis thaliana) mutants with altered sugar sensitivity revealed the function of abscisic acid (ABA) signalling in sugar responses. However, the exact interaction between sugar signalling and ABA... | [
"abscisic acid",
"seedling development",
"sugar signalling",
"glucose insensitive",
"aba insensitive"
] | [
"P",
"P",
"P",
"P",
"P"
] |
Ann_Biomed_Eng-2-2-1705502 | Single-Step 3-D Image Reconstruction in Magnetic Induction Tomography: Theoretical Limits of Spatial Resolution and Contrast to Noise Ratio
| Magnetic induction tomography (MIT) is a low-resolution imaging modality for reconstructing the changes of the complex conductivity in an object. MIT is based on determining the perturbation of an alternating magnetic field, which is coupled from several excitation coils to the object. The conductivity distribution is ... | [
"magnetic induction tomography",
"regularization",
"inverse problem",
"passive electrical properties",
"conductivity imaging"
] | [
"P",
"P",
"P",
"M",
"R"
] |
Eur_J_Pediatr-4-1-2413080 | Growth charts for Wolf-Hirschhorn syndrome (0–4 years of age)
| Wolf-Hirschhorn syndrome is characterized by severe growth and mental retardation, microcephaly, seizures and ‘Greek helmet’ facies, caused by partial deletion of the short arm of chromosome 4. Growth charts are given from 0–4 years of age, based on the study of 101 individuals. Use of these specific growth charts is r... | [
"growth",
"growth charts",
"wolf-hirschhorn",
"whs"
] | [
"P",
"P",
"P",
"P"
] |
Pediatr_Nephrol-4-1-2335288 | Chronic kidney disease after liver, cardiac, lung, heart–lung, and hematopoietic stem cell transplant
| Patient survival after cardiac, liver, and hematopoietic stem cell transplant (HSCT) is improving; however, this survival is limited by substantial pretransplant and treatment-related toxicities. A major cause of morbidity and mortality after transplant is chronic kidney disease (CKD). Although the majority of CKD afte... | [
"chronic kidney disease",
"hematopoietic stem cell transplant",
"calcineurin inhibitors",
"risk factors",
"epidemiology",
"liver transplant",
"cardiac transplant",
"lung transplant"
] | [
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"P"
] |
World_J_Urol-3-1-1913171 | The influence of thermo-chemotherapy on bladder tumours: an immunohistochemical analysis
| To study the influence of microwave induced thermo-chemotherapy on high-grade urothelial cell carcinomas. Five groups of each three patients were formed of whom initial biopsies and cystectomy samples were collected. Patients were treated 2 days prior to cystectomy with mitomycin-C (group 1), hyperthermia (group 2) or ... | [
"chemotherapy",
"hyperthermia",
"ki-67",
"p53",
"superficial bladder cancer"
] | [
"P",
"P",
"P",
"P",
"P"
] |
J_Gastrointest_Surg-3-1-1852393 | CD24 Expression is an Independent Prognostic Marker in Cholangiocarcinoma
| CD24 has been described as an adverse prognostic marker in several malignancies. This study evaluates CD24 expression in cholangiocarcinoma and correlates the findings with clinicopathologic data and patient survival. Between 1996 and 2002, 22 consecutive patients with cholangiocarcinoma were treated at our institution... | [
"cd24 expression",
"cholangiocarcinoma",
"survival"
] | [
"P",
"P",
"P"
] |
Knee_Surg_Sports_Traumatol_Arthrosc-4-1-2358931 | A cadaveric analysis of contact stress restoration after osteochondral transplantation of a cylindrical cartilage defect
| Osteochondral transplantation is a successful treatment for full-thickness cartilage defects, which without treatment would lead to early osteoarthritis. Restoration of surface congruency and stability of the reconstruction may be jeopardized by early mobilization. To investigate the biomechanical effectiveness of oste... | [
"transplantation",
"cartilage",
"biomechanics",
"humans",
"pressure",
"weight-bearing",
"articular/pathology",
"knee joint/surgery",
"surface properties",
"autologous"
] | [
"P",
"P",
"P",
"P",
"P",
"P",
"M",
"R",
"M",
"U"
] |
Knee_Surg_Sports_Traumatol_Arthrosc-3-1-1779626 | Membrane-seeded autologous chondrocytes: cell viability and characterization at surgery
| The implantation of chondrocytes, seeded on matrices such as hyaluronic acid or collagen membranes, is a method that is being widely used for the treatment of chondral defects. The aim of the present study was to evaluate the distribution, viability and phenotype expression of the cells seeded on a collagen membrane ju... | [
"chondrocytes",
"cells",
"articular cartilage",
"tissue engineering",
"cultured",
"histocytochemistry"
] | [
"P",
"P",
"P",
"P",
"P",
"U"
] |
Cancer_Causes_Control-2-2-1764867 | Wine and other alcohol consumption and risk of ovarian cancer in the California Teachers Study cohort
| Objective Whether alcohol consumption influences ovarian cancer risk is unclear. Therefore, we investigated the association between alcohol intake at various ages and risk of ovarian cancer.
Introduction
Consistent evidence that moderate alcohol consumption increases the risk of breast cancer, presumably by elevating e... | [
"ovarian cancer",
"cohort studies",
"alcoholic beverages",
"women’s health"
] | [
"P",
"P",
"P",
"R"
] |
J_Urban_Health-2-2-1705540 | Methods to Recruit Hard-to-Reach Groups: Comparing Two Chain Referral Sampling Methods of Recruiting Injecting Drug Users Across Nine Studies in Russia and Estonia
| Evidence suggests rapid diffusion of injecting drug use and associated outbreaks of HIV among injecting drug users (IDUs) in the Russian Federation and Eastern Europe. There remains a need for research among non-treatment and community-recruited samples of IDUs to better estimate the dynamics of HIV transmission and to... | [
"injecting drug users",
"estonia",
"hiv",
"respondent-driven sampling",
"indigenous field workers",
"russia."
] | [
"P",
"P",
"P",
"P",
"P",
"P"
] |
Skeletal_Radiol-3-1-2042032 | Are radiographs needed when MR imaging is performed for non-acute knee symptoms in patients younger than 45 years of age?
| Objective The objective was to determine the value of radiographs in young adults with non-acute knee symptoms who are scheduled for magnetic resonance imaging (MRI).
Introduction
Radiographs in patients with acute knee problems that are obtained at, or close to, the time of trauma serve mainly to exclude fractures and... | [
"radiographs",
"knee",
"magnetic resonance imaging"
] | [
"P",
"P",
"P"
] |
Int_Arch_Occup_Environ_Health-3-1-1915641 | Work-related physical and psychosocial risk factors for sick leave in patients with neck or upper extremity complaints
| Objectives To study work-related physical and psychosocial risk factors for sick leave among patients who have visited their general practitioner for neck or upper extremity complaints.
Introduction
Many people suffer from work-related neck and upper extremity complaints. In a population-based study in the Netherlands,... | [
"sick leave",
"neck",
"upper extremity",
"workload",
"cohort study"
] | [
"P",
"P",
"P",
"P",
"P"
] |
Curr_Eye_Res-1-1-2430176 | Branch Retinal Vein Occlusion: Pathogenesis, Visual Prognosis, and Treatment Modalities
| In branch retinal vein occlusion (BRVO), abnormal arteriovenous crossing with vein compression, degenerative changes of the vessel wall and abnormal hematological factors constitute the primary mechanism of vessel occlusion. In general, BRVO has a good prognosis: 50–60% of eyes are reported to have a final visual acuit... | [
"branch retinal vein occlusion",
"pathogenesis",
"visual prognosis",
"treatment",
"risk factors"
] | [
"P",
"P",
"P",
"P",
"P"
] |
Curr_Genet-4-1-2413079 | A codon-optimized luciferase from Gaussia princeps facilitates the in vivo monitoring of gene expression in the model alga Chlamydomonas reinhardtii
| The unicellular green alga Chlamydomonas reinhardtii has emerged as a superb model species in plant biology. Although the alga is easily transformable, the low efficiency of transgene expression from the Chlamydomonas nuclear genome has severely hampered functional genomics research. For example, poor transgene express... | [
"luciferase",
"gaussia princeps",
"chlamydomonas reinhardtii",
"reporter gene",
"bioluminescence",
"heat-inducible expression"
] | [
"P",
"P",
"P",
"P",
"P",
"R"
] |
Osteoporos_Int-3-1-1820756 | Bone loss in elderly men: increased endosteal bone loss and stable periosteal apposition. The prospective MINOS study
| Introduction Longitudinal studies on the age-related bone loss in men concerns the decrease in areal bone mineral density (aBMD), which can be qualified as “apparent bone loss” because it does not reflect the change in bone mineral content (BMC). Loss of BMC can be referred to as “net bone loss” because it does not tak... | [
"bone loss",
"men",
"periosteal apposition",
"osteoporosis"
] | [
"P",
"P",
"P",
"P"
] |
Eur_J_Pediatr-4-1-2292481 | Symptomatic asymmetry in the first six months of life: differential diagnosis
| Asymmetry in infancy is a clinical condition with a wide variation in appearances (shape, posture, and movement), etiology, localization, and severity. The prevalence of an asymmetric positional preference is 12% of all newborns during the first six months of life. The asymmetry is either idiopathic or symptomatic. Ped... | [
"symptomatic asymmetry",
"differential diagnosis",
"etiology",
"infant",
"screening",
"plagiocephaly",
"torticollis"
] | [
"P",
"P",
"P",
"P",
"P",
"P",
"P"
] |
J_Urban_Health-2-2-1705478 | Assessment of Respondent Driven Sampling for Recruiting Female Sex Workers in Two Vietnamese Cities: Reaching the Unseen Sex Worker
| Respondent driven sampling (RDS) is a relatively new method to sample hard-to-reach populations. Until this study, female sex workers (FSWs) in Vietnam were sampled using a variety of methods, including time location sampling (TLS), which may not access the more hidden types of FSWs. This paper presents an analysis fro... | [
"sex workers",
"vietnam",
"hiv",
"respondent-driven sampling"
] | [
"P",
"P",
"P",
"M"
] |
Purinergic_Signal-4-2-2377319 | Purinergic signaling microenvironments: An introduction
| The common theme of this introductory article and the minireviews that follow in this special issue is the concept of microenvironments within tissues and surrounding cells that would be ideal signaling venues for a biologically active purinergic ligand. Collectively, the editors/authors and the other contributing auth... | [
"signaling",
"nucleotides",
"nucleosides",
"adenosine",
"atp"
] | [
"P",
"P",
"P",
"P",
"P"
] |
Matern_Child_Health_J-2-2-1592154 | Women with Depression—“You Can't Tell by Looking”™
| Introduction
Perinatal depression, a mood disorder that occurs during pregnancy or the first year postpartum, affects 10–15% of women and up to 28% of women living in poverty. A previous history of depression, either preconceptionally or during the interconception period, is the strongest predictor that a woman will su... | [
"depression",
"perinatal",
"mood disorder",
"preconception"
] | [
"P",
"P",
"P",
"P"
] |
Addiction-1-_-2253702 | Social cognitive determinants of ecstasy use to target in evidence-based interventions: a meta-analytical review
| Aims The health hazards and prevalence of ecstasy use have been documented in two decades of research, but no review reporting on potentially modifiable antecedents of use is available. The aim of this study was to integrate systematically research identifying cognitive correlates of ecstasy use. Such research has the ... | [
"determinants",
"ecstasy",
"review",
"expectancies",
"drugs",
"theory of planned behaviour"
] | [
"P",
"P",
"P",
"P",
"P",
"P"
] |
Eur_J_Pediatr-3-1-2151775 | Incidence of late vitamin K deficiency bleeding in newborns in the Netherlands in 2005: evaluation of the current guideline
| Vitamin K prophylaxis is recommended to prevent the hazard of haemorrhage caused by vitamin K deficiency in newborns. The present Dutch guideline recommends 1 mg of vitamin K1 orally at birth, followed by a daily dose of 25 μg of vitamin K1 from 1 to 13 weeks of age for breastfed infants. Since the introduction of this... | [
"vitamin k",
"vitamin k deficiency",
"newborn",
"prophylaxis",
"infant"
] | [
"P",
"P",
"P",
"P",
"P"
] |
Pediatr_Nephrol-3-1-2064946 | Molecular mechanism of edema formation in nephrotic syndrome: therapeutic implications
| Sodium retention and edema are common features of nephrotic syndrome that are classically attributed to hypovolemia and activation of the renin–angiotensin–aldosterone system. However, numbers of clinical and experimental findings argue against this underfill theory. In this review we analyze data from the literature i... | [
"sodium retention",
"aldosterone",
"collecting duct",
"na,k-atpase",
"epithelial sodium channels (enacs)",
"diuretics",
"capillary hydraulic conductivity"
] | [
"P",
"P",
"P",
"P",
"P",
"P",
"P"
] |
Anal_Bioanal_Chem-3-1-1797063 | The effect of the chemical, biological, and physical environment on quorum sensing in structured microbial communities
| As researchers attempt to study quorum sensing in relevant clinical or environmental settings, it is apparent that many factors have the potential to affect signaling. These factors span a range of physical, chemical, and biological variables that can impact signal production, stability and distribution. Optimizing exp... | [
"quorum sensing",
"biofilm",
"clinical/biomedical analysis",
"cell systems/single cell analysis",
"biosensors"
] | [
"P",
"P",
"M",
"M",
"U"
] |
Dev_Biol-2-1-2279743 | Redundancy and evolution of GATA factor requirements in development of the myocardium
| The transcription factors, GATA4, 5 and 6, recognize the same DNA sequence and are all expressed in the developing myocardium. However, knockout studies in the mouse have indicated that none of them are absolutely required for the specification of the myocardium. Here we present evidence for redundancy in this family f... | [
"redundancy",
"evolution",
"xenopus",
"zebrafish",
"bmp",
"nkx",
"heart",
"feedback loops",
"gene networks"
] | [
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"R"
] |
Bioinformation-2-1-2139994 | Hypo, hype and ‘hyp’ human proteins
| Genes with unknown function are called orphan genes while their transcripts and peptides are called hypothetical proteins. There are many genes and their associated proteins that remain uncharacterized in the human genome. A database of human hypothetical proteins with ascribed functions could be helpful for biologists... | [
"hypothetical proteins",
"database",
"networks",
"mining"
] | [
"P",
"P",
"P",
"P"
] |
Cancer_Immunol_Immunother-3-1-1914259 | No evidence for circulating HuD-specific CD8+ T cells in patients with paraneoplastic neurological syndromes and Hu antibodies
| Aim In paraneoplastic neurological syndromes (PNS) associated with small cell lung cancer (SCLC) and Hu antibodies (Hu-PNS), Hu antigens expressed by the tumour hypothetically trigger an immune response that also reacts with Hu antigens in the nervous system, resulting in tumour suppression and neuronal damage. To gain... | [
"hud",
"paraneoplastic",
"sclc",
"anti-tumour immunity",
"t lymphocyte",
"hla class i multimer"
] | [
"P",
"P",
"P",
"P",
"R",
"R"
] |
Rev_Endocr_Metab_Disord-3-1-1894828 | Noonan syndrome and related disorders: Alterations in growth and puberty
| Noonan syndrome is a relatively common multiple malformation syndrome with characteristic facies, short stature and congenital heart disease, most commonly pulmonary stenosis (Noonan, Clin Pediatr, 33:548–555, 1994). Recently, a mutation in the PTPN11 gene (Tartaglia, Mehler, Goldberg, Zampino, Brunner, Kremer et al., ... | [
"noonan syndrome",
"short stature",
"cardio-facio-cutaneous syndrome",
"costello syndrome",
"leopard syndrome",
"growth hormone"
] | [
"P",
"P",
"P",
"P",
"P",
"P"
] |
Eur_J_Clin_Pharmacol-3-1-1914304 | Hypothermia following antipsychotic drug use
| Objective Hypothermia is an adverse drug reaction (ADR) of antipsychotic drug (APD) use. Risk factors for hypothermia in ADP users are unknown. We studied which risk factors for hypothermia can be identified based on case reports.
Introduction
Antipsychotic drugs (APDs) can influence thermoregulation. Even before its p... | [
"hypothermia",
"thermoregulation",
"schizophrenia",
"adverse drug effect",
"antipsychotic agents"
] | [
"P",
"P",
"P",
"P",
"M"
] |
Virchows_Arch-3-1-1888718 | Frequency and diagnostic patterns of lymphomas in liver biopsies with respect to the WHO classification
| The recent World Health Organization (WHO) classification of hematopoietic and lymphoid tissue tumors represents the first worldwide consensus classification of these malignancies. However, the applicability of this classification to a representative number of hepatic lymphomas in liver biopsy specimens has not yet bee... | [
"lymphoma",
"liver",
"pcr",
"immunohistochemistry",
"differential diagnosis"
] | [
"P",
"P",
"P",
"P",
"P"
] |
Int_Urogynecol_J_Pelvic_Floor_Dysfunct-3-1-2062491 | Is there an association between depressive and urinary symptoms during and after pregnancy?
| Depressive symptoms and urinary symptoms are both highly prevalent in pregnancy. In the general population, an association is reported between urinary symptoms and depressive symptoms. The association of depressive and urinary symptoms has not yet been assessed in pregnancy. In this study, we assessed (1) the prevalenc... | [
"depression",
"pregnancy",
"urge urinary incontinence",
"stress urinary incontinence",
"ces-d",
"over-active bladder syndrome"
] | [
"P",
"P",
"P",
"P",
"P",
"P"
] |
Matern_Child_Health_J-4-1-2335294 | Preconception Brief: Occupational/Environmental Exposures
| In the last decade, more than half of U.S. children were born to working mothers and 65% of working men and women were of reproductive age. In 2004 more than 28 million women age 18–44 were employed full time. This implies the need for clinicians to possess an awareness about the impact of work on the health of their p... | [
"environmental exposure",
"reproductive",
"reproductive toxicants"
] | [
"P",
"P",
"P"
] |
Cancer_Immunol_Immunother-3-1-2150627 | The CIMT-monitoring panel: a two-step approach to harmonize the enumeration of antigen-specific CD8+ T lymphocytes by structural and functional assays
| The interpretation of the results obtained from immunomonitoring of clinical trials is a difficult task due to the variety of methods and protocols available to detect vaccine-specific T-cell responses. This heterogeneity as well as the lack of standards has led to significant scepticism towards published results. In F... | [
"standardization",
"tetramer",
"elispot",
"interlaboratory testing"
] | [
"P",
"P",
"P",
"P"
] |
Histochem_Cell_Biol-3-1-2137945 | Physiological importance of RNA and protein mobility in the cell nucleus
| Trafficking of proteins and RNAs is essential for cellular function and homeostasis. While it has long been appreciated that proteins and RNAs move within cells, only recently has it become possible to visualize trafficking events in vivo. Analysis of protein and RNA motion within the cell nucleus have been particularl... | [
"rna",
"dynamics",
"diffusion",
"nuclear architecture"
] | [
"P",
"P",
"P",
"P"
] |
Mod_Rheumatol-4-1-2279153 | Retrospective clinical study on the notable efficacy and related factors of infliximab therapy in a rheumatoid arthritis management group in Japan: one-year clinical outcomes (RECONFIRM-2)
| Biologics targeting TNF have brought about a paradigm shift in the treatment of rheumatoid arthritis (RA) and infliximab, anti-TNF-α chimeric monoclonal antibody, was marketed in 2003 in Japan. We previously reported on the RECONFIRM study, a retrospective clinical study on the efficacy of infliximab therapy in a RA ma... | [
"infliximab",
"rheumatoid arthritis",
"eular response",
"retrospective study"
] | [
"P",
"P",
"P",
"P"
] |
Eur_J_Epidemiol-3-1-2039783 | From evidence based bioethics to evidence based social policies
| In this issue, Norwegian authors demonstrate that causes of early expulsion out the workforce are rooted in childhood. They reconstruct individual biographies in administrative databases linked by an unique national identification number, looking forward 15 years in early adulthood and looking back 20 years till birth ... | [
"databases",
"disability",
"pensions",
"epidemiology",
"norway",
"risk factors",
"educational status",
"socioeconomic factors"
] | [
"P",
"P",
"P",
"P",
"P",
"R",
"R",
"M"
] |
Diabetologia-3-1-1914282 | The effect of moderate alcohol consumption on adiponectin oligomers and muscle oxidative capacity: a human intervention study
| Aims/hypothesis The aim of this study was to investigate whether moderate alcohol consumption increases plasma high molecular weight (HMW) adiponectin and/or muscle oxidative capacity.
Introduction
Moderate alcohol consumption is associated with a decreased risk of type 2 diabetes compared with abstention [1], which co... | [
"moderate alcohol consumption",
"adiponectin",
"muscle oxidative capacity",
"insulin sensitivity",
"intramyocellular triacylglycerols",
"high molecular weight adiponectin"
] | [
"P",
"P",
"P",
"P",
"P",
"R"
] |
Appl_Microbiol_Biotechnol-4-1-2243256 | Discovery and characterization of a putrescine oxidase from Rhodococcus erythropolis NCIMB 11540
| A gene encoding a putrescine oxidase (PuORh, EC 1.4.3.10) was identified from the genome of Rhodococcus erythropolis NCIMB 11540. The gene was cloned in the pBAD vector and overexpressed at high levels in Escherichia coli. The purified enzyme was shown to be a soluble dimeric flavoprotein consisting of subunits of 50 k... | [
"putrescine oxidase",
"flavin",
"amine",
"activity screening"
] | [
"P",
"P",
"P",
"P"
] |
Breast_Cancer_Res_Treat-3-1-2137941 | The spectrum of ATM missense variants and their contribution to contralateral breast cancer
| Heterozygous carriers of ATM mutations are at increased risk of breast cancer. In this case-control study, we evaluated the significance of germline ATM missense variants to the risk of contralateral breast cancer (CBC). We have determined the spectrum and frequency of ATM missense variants in 443 breast cancer patient... | [
"atm",
"missense variants",
"breast cancer",
"radiotherapy"
] | [
"P",
"P",
"P",
"P"
] |
Eur_J_Epidemiol-4-1-2270357 | Data splitting as a countermeasure against hypothesis fishing: with a case study of predictors for low back pain
| There is growing concern in the scientific community that many published scientific findings may represent spurious patterns that are not reproducible in independent data sets. A reason for this is that significance levels or confidence intervals are often applied to secondary variables or sub-samples within the trial,... | [
"data splitting",
"hypothesis fishing",
"low back pain",
"two-stage analysis",
"data dredging"
] | [
"P",
"P",
"P",
"P",
"P"
] |
Neurochem_Res-3-1-1832151 | The Role of Presenilin and its Interacting Proteins in the Biogenesis of Alzheimer’s Beta Amyloid
| The biogenesis and accumulation of the beta amyloid protein (Aβ) is a key event in the cascade of oxidative and inflammatory processes that characterises Alzheimer’s disease. The presenilins and its interacting proteins play a pivotal role in the generation of Aβ from the amyloid precursor protein (APP). In particular,... | [
"presenilin",
"interacting proteins",
"beta amyloid",
"alzheimer’s disease",
"amyloid precursor protein",
"gamma secretase"
] | [
"P",
"P",
"P",
"P",
"P",
"M"
] |
Biochim_Biophys_Acta-2-1-2396231 | Differential regulation of Krüppel-like factor family transcription factor expression in neonatal rat cardiac myocytes: Effects of endothelin-1, oxidative stress and cytokines
| Krüppel-like transcription factors (Klfs) modulate fundamental cell processes. Cardiac myocytes are terminally-differentiated, but hypertrophy in response to stimuli such as endothelin-1. H2O2 or cytokines promote myocyte apoptosis. Microarray studies of neonatal rat myocytes identified several Klfs as endothelin-1-res... | [
"krüppel-like factors",
"cardiac myocytes",
"endothelin-1",
"cytokines",
"immediate early genes",
"gene expression"
] | [
"P",
"P",
"P",
"P",
"P",
"P"
] |
Histochem_Cell_Biol-4-1-2248605 | Imaging and imagination: understanding the endo-lysosomal system
| Lysosomes are specialized compartments for the degradation of endocytosed and intracellular material and essential regulators of cellular homeostasis. The importance of lysosomes is illustrated by the rapidly growing number of human disorders related to a defect in lysosomal functioning. Here, we review current insight... | [
"imaging",
"lysosomes",
"protein sorting",
"trans-golgi network",
"mannose 6-phosphate receptor",
"endosomes",
"electron microscopy",
"lysosomal membrane proteins"
] | [
"P",
"P",
"P",
"P",
"P",
"P",
"P",
"P"
] |
Pediatr_Radiol-4-1-2367394 | Imaging findings in noncraniofacial childhood rhabdomyosarcoma
| Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma of childhood. This paper is focuses on imaging for diagnosis, staging, and follow-up of noncraniofacial RMS.
Introduction
Rhabdomyosarcoma (RMS) is the most common paediatric soft-tissue sarcoma and constitutes 3–5% of all malignancies in childhood [1]. In c... | [
"imaging",
"rhabdomyosarcoma",
"children"
] | [
"P",
"P",
"P"
] |
Obes_Surg-4-1-2367390 | Delayed Intrathoracic Gastric Perforation After Obesity Surgery: A Severe Complication
| We describe a case of a patient with an intrathoracic gastric perforation, 6 months after she underwent a gastric banding procedure for the treatment of morbid obesity. After an urgent laparotomy during which the stomach was replaced and oversewn, she recovered uneventfully. The possible mechanism of this severe compli... | [
"gastric perforation",
"complication",
"gastric banding",
"morbid obesity",
"bariatric surgery"
] | [
"P",
"P",
"P",
"P",
"M"
] |
J_Biol_Inorg_Chem-3-1-2099461 | A steady-state and pre-steady-state kinetics study of the tungstoenzyme formaldehyde ferredoxin oxidoreductase from Pyrococcus furiosus
| Formaldehyde ferredoxin oxidoreductase from Pyrococcus furiosus is a homotetrameric protein with one tungstodipterin and one [4Fe–4S] cubane per 69-kDa subunit. The enzyme kinetics have been studied under steady-state conditions at 80 °C and pre-steady state conditions at 50 °C, in the latter case via monitoring of the... | [
"pre-steady-state kinetics",
"steady-state kinetics",
"pyrococcus furiosus",
"tungsten",
"formaldehyde oxidoreductase"
] | [
"P",
"P",
"P",
"P",
"P"
] |
Ann_Hematol-4-1-2275303 | Practical recommendations on the use of lenalidomide in the management of myelodysplastic syndromes
| Lenalidomide, an oral immunomodulatory agent, has received approval in the USA from the Food and Drug Administration (FDA) for the management of myelodysplastic syndromes (MDS) classified by the International Prognostic Scoring System (IPSS) as low risk or intermediate-1 risk and with a deletion 5q (del(5q)) cytogeneti... | [
"lenalidomide",
"myelodysplastic syndromes",
"mds",
"treatment guidelines"
] | [
"P",
"P",
"P",
"R"
] |
Environ_Manage-2-2-1705511 | Perceived Conflicts Between Pastoralism and Conservation of the Kiang Equus kiang in the Ladakh Trans-Himalaya, India
| An emerging conflict with Trans-Himalayan pastoral communities in Ladakh’s Changthang Plateau threatens the conservation prospects of the kiang (Equus kiang) in India. It is locally believed that Changthang’s rangelands are overstocked with kiang, resulting in forage competition with livestock. Here, we provide a revie... | [
"conflicts",
"pastoralism",
"equus kiang",
"ladakh",
"livestock",
"nomads"
] | [
"P",
"P",
"P",
"P",
"P",
"P"
] |
Semin_Immunopathol-3-1-2071951 | Complement in glomerular injury
| In recent years, research into the role of complement in the immunopathogenesis of renal disease has broadened our understanding of the fragile balance between the protective and harmful functions of the complement system. Interventions into the complement system in various models of immune-mediated renal disease have ... | [
"complement",
"glomerulonephritis",
"immune complexes",
"hemolytic uremic syndrome"
] | [
"P",
"P",
"P",
"M"
] |
J_Chem_Ecol-3-1-2039843 | Flower vs. Leaf Feeding by Pieris brassicae: Glucosinolate-Rich Flower Tissues are Preferred and Sustain Higher Growth Rate
| Interactions between butterflies and caterpillars in the genus Pieris and plants in the family Brassicaceae are among the best explored in the field of insect–plant biology. However, we report here for the first time that Pieris brassicae, commonly assumed to be a typical folivore, actually prefers to feed on flowers o... | [
"brassica nigra",
"nutrition",
"herbivory",
"myrosinase",
"isothiocyanates",
"lepidoptera",
"pieridae"
] | [
"P",
"P",
"P",
"P",
"P",
"P",
"U"
] |
Hum_Reprod-1-1-2387218 | Cell identity in the preimplantation mammalian embryo: an epigenetic perspective from the mouse
| The early preimplantation mouse embryo is a unique system where it is possible to explore the foundations of totipotency and differentiation. Following fertilization, a single cell, the zygote, will give rise to all tissues of the organism. The first signs of differentiation in the embryo are evident at the blastocyst ... | [
"epigenetics",
"mouse embryo",
"cell fate",
"pluripotency",
"histone methylation"
] | [
"P",
"P",
"P",
"P",
"P"
] |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.