Entry stringlengths 6 10 | EC_number stringclasses 260
values | Active_site stringlengths 0 544 | Sequence stringlengths 20 2.05k | labels int16 1 260 |
|---|---|---|---|---|
Q5K917 | 1.11.1.6 | ACT_SITE 59; /evidence="ECO:0000256|PIRSR:PIRSR038928-1"; ACT_SITE 132; /evidence="ECO:0000256|PIRSR:PIRSR038928-1" | MTEKTPTYTLSEGCPIADATTAQRLGSCPVKGLMLMQDTQLIETLAHFSRERIPERTVHASAVGAWGEFEVTHDNSDITSAAFLNGIGKKSKVLMRISTVGPEAGTAETVRDVRGWSMKIFTEEGNQDFVFNSIPVFFIRDPIKFPSVNRSHKRHPAKHTADSSMFWDFHNNNPEGTHAIMMYFSNRGLPYSLRQINSYSGHTYKLTKSDGSFVYVKLHFKSNQGVKGMTQAEGVRTAGEAPDFHTTDMWDAIERGDYPTWTLYAQVMKPEEAENYRWNIFDMTKVWPHKDFPLRPLGKLTLNRNPENYFSDIEQAAFSP... | 13 |
T1FM52 | 4.2.1.11 | ACT_SITE 210; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001400-1"; ACT_SITE 344; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR001400-1" | MVIQKLHARQIFDSRGNPTVEVDLTTDKGTFRAAVPSGASTGIHEALELRDKVAADYHGKGVLKAVGNINNIIAPALVGKEIDVTNQSCVDEFLLKLDGTENKSKLGANAILGVSLAVCQAGAKQKGVPLYRHIADLAGNKELVLPVPAFNVINGGSHAGNKLAMQEFMLLPTGASSFTQAMKMGSEVYHHLKSVIKAKYGQDACNVGDEGGFAPNIQNNEEGLELLKTAIEKAGYTGKIEIGMDVAASEFYKSEKYDLDFKNPKSDPAQWLTSDQLFEVYKGFLAKYPVVSIEDAFDQDDWAAWTKMNSQVQIQLVGDD... | 200 |
F6PKW3 | 2.7.10.2 | ACT_SITE 698; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000632-1" | MEFSSSLLGKPSHEALIRLQDYEIKLLEVIKKTILGRIEHDRKYSNMLSQLANHGLKIENSMFQSPIFNVSEAWKEIVHSMLQTSHCIKKSADFMQSSTLDKVTALIKDKTTIRKNYTENRERIDHKFVKTIHTELDKKHSSYMKLETEVAQAHKAYDAAVEKGKGKFNPIEKAQDKYRKTTMKLHHAHNDYTLQVMEAQLHQHQYRNQVLPELLSGMQHMETECAETLKQALHEFLTYSSPCREELVSCHKEAENAVMNIDSHQEFDSFIQTQRTPLEPEANITYEVMKGEAANLPMGQIVLNNLSMQGVEHIAQGYQE... | 98 |
A0A804I8T9 | 3.1.1.11 | ACT_SITE 387; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MASSLTWSLFLASLLFLFTLPSPTLSSDVVSSSGNTNAESSVRDLCRSTPYPAACLDSLKLSVSITINPSVLSLALRTLQAAISEAAKLSSVLSSAGRPGAVVESQRSSLQDCQELHQITVASLRRSAGLVKPEARKLADARAYLAAALTNRATCLEGLAGARGPLKATLVDSWLAAYAHVSNSLSLVARSGGRKGRRLSSARPFRSRGGGGFPAWVGRRERRLLQDGDYGDVDPGSVVTVAADGTGNFTTLGEAVAWAPSNSDDRTIILVRAGVYEEHVDIPSDKTNIVLIGDGSDVTVIRGNRSVGDGWTTFRSATVA... | 125 |
Q86M34 | 3.2.1.52 | ACT_SITE 347; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:P07686" | MIVLLLLISYCFAGNGVNVKNQLLLMPYPTTVNAQFGSNDCVEATSNIKMVLSNNCQNDPNCLSFMTFNFNHTITYPLQRQRNLEDFRVSIFAPIDIEEMKGNVVYSANTVNIELTGNNIEEIYPPLKIGIDESYSLDVTKEGIKISATTVYGARLGLETLIQMLRPYQGKYIIKHIPIMIEDKPRLQWRGLMIDVARNSFSRSAFVKIINAMAAIKANVLHIHLSDAQTFMFESKEYPELSKKGAFFQNKVLTQSFIKQLVQYGAKRGVIVYPEIDTPAHTASWNAGYPGVVADIWDYIVSSSMRYGENVLALNPANEK... | 170 |
W5NAK4 | 2.7.11.1 | ACT_SITE 146; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038172-1" | CHDTAVMDPQNRAALDISTRNPQDDFEILHRVGGGTYGEVYKARNKQSGELAAIKIIKTEPEDDFSVIQQEIVMVKSCTHSNIVAYFGSYIRANKLWICMEYCGGGSLQDVYHVTGPLSEQQIAYVCREMLKGLEYLHSQKKIHRDIKGANILLNDQGEVKLADFGISAQITATFARRMSFIGTPYWMAPEVAAVEIKGGYNELCDIWSVGITAIELAELQPPMFDVHPLRVLFLMSKSGYQPPKLKDKAKWSSVFHNFIKMMLIRNPKKRPNASKMLTHVFVTQSSLNRTLTLELLEQMRHPEKLKDCVQLEEEEMEVL... | 99 |
Q54XL6 | 2.7.11.1 | ACT_SITE 221; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:P28523, ECO:0000255|PROSITE-ProRule:PRU00159" | MEINNSNNNNNYVCAQHNRIEHANHHDLPDSDSDSSSREEELMNSSGGGNGKEPIGEKKKLPSHISEVISNERRESIIRELQQIKTISDYPSQANQYNLIEPIGEGTEGRVFKAYCIPLKENVAIKVVELDKMDPQFVKDVIKEVKVMNGNNHPNLIHYHTSFLENNQLWLVMDYLGGGSLADIMKFKYPDGIPEVLAVTVLKSLLKGLEYLHSHQRIHRDLKSDNILIGEDGAIELADFGVSAMFEKNTCCSRKTIVGTPCWMAPEIISERGYNQGVDIWSFGITAIELIRGKPPGYDLPPSKVFMNLLFGNSPSLQEE... | 99 |
P48496 | 5.3.1.1 | ACT_SITE 162; /note="Electrophile"; /evidence="ECO:0000250"; ACT_SITE 232; /note="Proton acceptor"; /evidence="ECO:0000250" | MAVVSTSLASQITNPNSAVSTQFSGLRRSFLKLENSVSTQSSFFQNVDSHLRLSSSSRRCPRGVVAMAGSGKFFVGGNWKCNGTKESITKLVSDLNSATLEADVDVVVAPPFVYIDQVKSSLTGRVEISAQNCWIGKGGAFTGEISVEQLKDLGCQWVILGHSERRHVIGEQNEFIGKKAAYALNQGVGVIACIGELLEEREAGKTFDVCYQQLKAFADALPSWDNVVVAYEPVWAIGTGKVASPDQAQEVHVAVRDWLKKNVSEEVASKTRIIYGGSVNGGNCAELAKQEDIDGFLVGGASLKGPEFATIVNSVTAKKV... | 213 |
A0A9R0IGR7 | 3.1.1.11 | ACT_SITE 264; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MKLKSTTLFWLLAFVTALVSIAFTTTFFNSPSSNLSVVIKKATTLDEFLGVVKEIADGLLRRHHHHHHHHHSHHHHHHHHHHHHREMPDMACSESKWGSTLSSSYRVSLTITVDLHGCGNFSSVQKAVDAVPDFSSSFTLIILDSGLYKEKVMINANKTNLIFQGQGYQNTAIAWNDTSNSTGGTANSASVTIFAPGFIAYNISFQNTAPEPSPGDKGGQAVALKISSDKAAFYGCGFYGSQDTLNDDRGRHYFKDCFIQGSIDFIFGEARSLYQNCTINSIAQGNEQGVDGSITAHGRQSEDESTGFSFVNCKIGGIGR... | 125 |
A9RVK2 | 2.7.11.25 | ACT_SITE 554; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MVEERGSSRSSRGGSWGSGEDGGSSHGGKGVPKLSRTVAKKIHKYDVSADHSDYEDDGSVHSTSSSGSRRNPLSKSIIQQQSFRVGANFEEDLKTLYELIGVSKPADLAISASDWQSRGKSIAYSQPLSSPSLSQEHGEASHSNDLKPSIIDFRSEAPAASPRELPVAPVKLDAHERMTYRSDYVNSQPQNHYGRKNSPSQRSPPPESFPAFDSSPSRLGREGYGLHRMQSDPVMPTLGALSPLGTGNAHPESAGSTATRRWSFDLVPGNHEGDYANMSQVVRDNLPSAAVAMPKNGLVRRSPIIRDPNRSNSSVSNPYA... | 105 |
A0A0A0KD24 | 3.1.1.11 | ACT_SITE 414; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MSNGFANAEGDKKKKKIAIISVSSLILVAMVVAVTVGVNNAPHGEEHGDDNHGSETTPEITSSTKAIQAICQPTDYKETCEKSLEAEAGNTTDPKELVKVGFKIATRSLNEAIKNSTTLKELAKDPRTNQALQNCRELLEYAIDDLNQSFERIGTFQMSKLDDFVADLKIWLSGALTYEQTCLDGFENTTGDAGVRMQEFLKSAQQMTTNGLGIVNELSTILGSLQLPGMSGRRLLEDDDREMPSWVSDGKRRLMQAGAAAMKPDLVVAQDGSGKYKTINAALADVPLKSNKTFVIHVKAGIYKEIVVIPKHMTHLTMYG... | 125 |
P37470 | 3.1.1.29 | ACT_SITE 19; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00083" | MLVIAGLGNPGKNYENTRHNVGFMVIDQLAKEWNIELNQNKFNGLYGTGFVSGKKVLLVKPLTYMNLSGECLRPLMDYYDVDNEDLTVIYDDLDLPTGKIRLRTKGSAGGHNGIKSLIQHLGTSEFDRIRIGIGRPVNGMKVVDYVLGSFTKEEAPEIEEAVDKSVKACEASLSKPFLEVMNEFNAKV | 127 |
A0CF81 | 3.4.19.12 | ACT_SITE 301; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR016308-1"; ACT_SITE 734; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR016308-1" | MTSICEHIIEQHITWSVQGQMIYKDQCTRCFVEAKSDNGIQVCLKCFNGGCIEMHSPQHSDQHNHYVVLNIRLFEIEQPQQKVEEINKLVIADIPQLECETSVTCLKCQKALNSPELDGLVQSIKQANSAFKRQAIAQWEHTAQPCEHTLTMEQIPLVEKNLQKCRSCHLSSNLWLCLYCGHVGCGRKVYDGSGGNNHAVDHSKEFQHHLVVKLGTITSDGKGDVFCYKCDDEVVDNFLKEHLATYGIEIEKQVKTEKTIAELTLDANLSLQLSKLIEEGQVLDPIFGPEFTGIDNIGNTCYMNSVVQVLFSIPEFQKLY... | 175 |
A0A804HWS1 | 1.11.1.7 | ACT_SITE 88; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MGGRSSFLRVALLTFSLGFYFVSCCVGFVEGGYSNATKRKRVPVRHQLSLDFYANTCPHVDQLVASVTARRFRDSPASGAATIRLFFHDCFVEGCDASILIAPTTGGKVVVERDVEDNKNLAPEAFETVEMAKALVESKCPGMVTCADILAMAARDFVRLAGGPNYGVKKGRKDSRVSMAGKVRGNLPRANSTVDELIRLFAAKGFRTEDLVALSGAHTIGFSHCDQFVSRLYDFRGTGEPDPSIDLRLLKALRMSCPRSGGNNDVVAPFDVQTPFSFDHMYYGNLEAKMGLLATDQALFLDPRTRPLVQGLGRDKVRFF... | 14 |
A0A0K9PLP9 | 3.1.1.11 | ACT_SITE 390; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MDRDKYYSMMIVFIASFFFLVPGETFHVDHVLTECSLTRYPQKCSQTLLSSFNLKQQQLPISSDNEVDQRRANMLYSLVQKAKEQTLASTQHISKNLYYPLGVGETKSSVLDYCDELMQMCAKRLDQSIHALKTSPKKSKSDIQTWLSGVLTFQEACKDSLTPSDSTTSSEIFDKIDHLSMLTSNALAFANRISGSYYVRAKDVKSTTTAERKLASAFPEWVSMDDRRLLEDGSVNTFKPHVVVAQDGSGDCSTILEGLKMVGTSQKGGGKKVIYIKAGVYKQKLKISEDNVMLVGEGKGSTVITQSSSVGGGTSMPNTA... | 125 |
A0A1S4ALZ9 | 3.4.19.9 | ACT_SITE 257; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1" | MSNYYFITISLFVAVVATAIESSSELSVPAGCPVPDPRLNYRPVIGIISHPGDGASGRIVNSTSVSYVAASYVKFVESAGARVIPLLFDDSPQVLNQKLDLVNGVIFPGGWARKGKYFETVKAIFKKVLEKNDAGEHFPLLAINLGFELLMMIVSKDNNILEKFSVSNQASKLHFVETVNIEDTVFGRFPPTLIKKLSKECLVLQRNKYGLSPEKFQANDDLSSFFIMLTTSTDTRNKVFVSTLQAENYPITALQWHPEKSAFEWGSAAIPHSEDAVQVTQLVANYFVSEARKSSNKPDAQKVLDNLIYNYSPTYSGKAG... | 176 |
Q03019 | 3.1.3.48 | ACT_SITE 318; /evidence="ECO:0000250" | MASKRLMLDVEEEDDESGACGQENFDPHDADMEYQAKRRKSAVQETPLQWMLKRHIPASTTVLSPITELSQNMNGARLDGTPKSTQRIPANRTLNNFNSLSSRTLGSFSSSCSSYESGNSLDDEYMDMFEMESAENHNLELPDDLEVLLSGQLKSESNLEEMSNKKGSLRRCLSMYPSEQPEEAVQEPDQETNMPMKKMQRKTLSMNDAEIMRALGDEPELIGDLSKPCTLPCLATGIRHRDLKTISSDTLARLIQGEFDEQLGSQGGYEIIDCRYPYEFLGGHIRGAKNLYTRGQIQEAFPTLTSNQENRRIYVFHCEF... | 149 |
O04482 | 3.4.19.12 | ACT_SITE 82; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01393, ECO:0000305|PubMed:17559514"; ACT_SITE 157; /note="Proton donor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01393" | MSWCTIESDPGVFTELIQQMQVKGVQVEELYSLDSDSLNNLRPVYGLIFLFKWQAGEKDERPTIQDQVSNLFFANQVINNACATQAILAILLNSPEVDIGPELSALKEFTKNFPSDLKGLAINNSDSIRAAHNSFARPEPFVPEEQKAATKDDDVYHFISYIPVDGVLYELDGLKEGPISLGPCPGDQTGIEWLQMVQPVIQERIERYSQSEIRFNLLAVIKNRKDIYTAELKELQRQREQLLQQANTCVDKSEAEAVNALIAEVGSGIEAASDKIVMEEEKFMKWRTENIRRKHNYIPFLFNFLKLLAEKKQLKPLIEK... | 175 |
H2N176 | 3.2.1.23 | ACT_SITE 184; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR006336-1"; ACT_SITE 264; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR006336-1" | MRLILSLLRLSFLLTVLSVQRLWAAPSFSLDYNADCFRKDGQRFRFISGSIHYSRIPRVYWKDRLVKMYMAGLNAIQTYIPWNYHEESPGMYNFSGDRDVEYFLKLAQDIGLLVILRPGPYICAEWEMGGLPAWLLSKKDIVLRSSDPDYVAAVDTWMGKLLPMMKPYLYQNGGPIITVQVENEYGSYFACDYNYMRHLTKLFRSHLGEDVVLFTTDGAGLNYLKCGAIQGLYASVDFGPGSNITAAFEAQRHAEPHGPLVNSEFYTGWLDHWGSRHSVVSPDLVAKSLNQQLAMGANVNMYMFIGGTNFGYWNGANSPY... | 163 |
A0A9J7K9F9 | 3.1.3.16 | ACT_SITE 113; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR640078-1"; ACT_SITE 115; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR640078-1" | MADRCINTCVLQPELYGHPEFLPGLSWFSYQEVGTGRRDQFLSHHAAAPVTTVAKKRHRSIFGSLLCCFRANSSHTPAAPGQPEENGSAKVPQKYLLPPVRHQDMHKKCIVIDLDETLVHSSFKPVTNADFIVPVEIDGTVHQVYVLKRPYVDEFLQKMGEMFECVLFTASLAKYADPVADLLDKWGVFRARLFRDSCVFHRGNYVKDLSRLGRDLCKVIIVDNSPASYIFHPDNAVPVASWFDDMSDTELLDLIPFLEGLAKVDDVYSVLRPQNHHVS | 144 |
Q9ZUE0 | 2.7.11.1 | ACT_SITE 495; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MSDLGESPSSSPPAPPADTAPPPETPSENSALPPVDSSPPSPPADSSSTPPLSEPSTPPPDSQLPPLPSILPPLTDSPPPPSDSSPPVDSTPSPPPPTSNESPSPPEDSETPPAPPNESNDNNPPPSQDLQSPPPSSPSPNVGPTNPESPPLQSPPAPPASDPTNSPPASPLDPTNPPPIQPSGPATSPPANPNAPPSPFPTVPPKTPSSGPVVSPSLTSPSKGTPTPNQGNGDGGGGGGGYQGKTMVGMAVAGFAIMALIGVVFLVRRKKKRNIDSYNHSQYLPHPNFSVKSDGFLYGQDPGKGYSSGPNGSMYNNSQQ... | 99 |
C0PKS1 | 1.11.1.7 | ACT_SITE 64; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MVRRTVLAALLVAAALAGGARAQLKEGFYDYSCPQAEKIVKDYVKAHIPHAPDVASTLLRTHFHDCFVRGCDASVLLNATGGSEAEKDAAPNLTLRGFGFIDRIKALLEKECPGVVSCADIVALAARDSVGVIVSAPDRVPPPPHASALPKPAKPIYKPVERACMQGGPFWSVPTGRRDGTVSIKQEALDQIPAPTMNFTQLLQSFQNKSLNLADLVWLSGAHTIGISQCNSFSERLYNFTGRGGPDDADPSLDPLYAAKLRLKCKTLTDNTTIVEMDPGSFRTFDLSYYRGVLKRRGLFQSDAALITDAASKADILSVI... | 14 |
A7S5I8 | 3.2.1.143 | ACT_SITE 238; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 256; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 257; /evidence="ECO:0000256|PIRSR:PIRSR607724-1" | RDKWDKDHVRMPCSTNNLYPMENSKKVQNRWELIESALLAPIKSSHDLQDAILKYNARYSSRWNFEALHCYFNEYLDSSDAQEFFDHTLPAMVRLTLQIPSVCTVAIPLMKRQKNHSITISQHQAACLLANAFFCTFPRRNSHKHSEYSNFPDINFNRLFQGGKGGTSTVKCEKLQSVLHYFRCVTQCTPTGTLTFHRQALQSEDLPKWERSSENFSRLHVSTKGNIEDDGTGFLQVDFANKYIGGGVIGEGCVQEEIRFLICPEMILSRLFCERLDSNECVFIIGAQRFSNYTGYAHTFKWAGHHDDKSIRDSWGRRYS... | 159 |
D6WQ66 | 3.1.3.16 | ACT_SITE 295; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR033096-1" | MNTEVKENCVITPELVEAGERYKAEANEYFKKQNYNAAIELYTKAIEANPNVAIYYGNRSFAYLKTECFGYALADASKAIELDKGYVKGFYRRAAAHMSLGKFKEALKDYEYVTKVRPNDKDAKSKYTECNKIVKKLAFEKAISVEDTKKNIASTINLDAMTIENEYTGPELEDGKVTLKFMKDLMELYKNQGKLHRKYAYKILLDVKAYFMKQPSLIDVVIGDEDKFTVCGDVHGQFYDLMNIFNLNGLPSETNPYLFNGDFVDRGSFSVECIFTLFGFKLLYPNHFFMSRGNHESATMNQMYGFDGEVKAKYTAQMAE... | 144 |
F4NYD5 | 3.1.3.16 | ACT_SITE 104; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR620405-1" | MDMAVNWQYEMRRDMQEIIPGLWLGPYSCARDNSLLHLKGITHILCVRESNEEMMVRMRFPEEFHYLCIQASDSPLQNLIPLFPKATSFIHTAITNGGSVLVHCNGGISRSPAFVVAYMMDMHDMQFATAFQFVQSKRFCMNPIEVFKYQLR | 144 |
A0A022QP16 | 1.11.1.7 | ACT_SITE 76; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MKMGAGRGMIVGLLMMMVVVVAVEGGSREYEYDDALSYGYYHGNCPQLEGIIHRKLHNWFKNDSTLAPALMRLHFHDCSVRGCDASILLNHKGSERKAKASKTLRGFQVIDDIKSEVERVCPKIVSCADILTAAARDATVAAGGPFWSVPYGRKDGRISLAKEAESVPMGHEKITDLIELFQSKGLNILDLVVLSGAHTIGRTSCDSLQFRLYNYKGTSKPDPTIDPKYLNFLRRKCRWASEYVDLDAVTPKAFDVQYYKNLQKKMGILSTDQMLYSDSRTAPLVSAFASQSSVFHHQFAASMVKLGNIQDFLADQHSEI... | 14 |
A0E1I3 | 2.7.11.1 | ACT_SITE 381; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR630616-1" | MFQPNQSQIKYHNPFGTTSAIYFSQQQTSRDKQMQSRDVSENKQTPQYPASQIVYGPTMKIVPSAQTNIAFRKISKELNITIEDPSNQQQSLRQPSPTVKKQREQMEKDWNKLIDKSKTLQENLVLLKNSISMNLTKKLPDQRLSKDSTSTAAGLSSRLKLQKVNINCKLNSPFKVQPKQELSKSLSQNTFTNLKYAANPIKNPVINNTSIMPLTNNTSVRKSQDSCTLQPKITSQFSSQKQTSSLYSSIEYKLNLKISSFLGRGKFSDVHMAIDQRSGLIFALKIIKKQTVIEHAMQEQLVREILIQSKLSHPNIVKMY... | 99 |
A0A1L8HA30 | 3.1.3.16 | ACT_SITE 107; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR640078-1"; ACT_SITE 109; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR640078-1" | MESSSIIAQVHREEALVHSKPGLVSKSSPKKPRSRSIFKALFCCLSAQNVSRPGGSSEPPIQKEETNATPKSDLLQCLQYQFYQIPGTSLLPEVAPKDKGKICMVIDLDETLVHSSFKPINNADFIVPVEIEGTTHQVYVLKRPYVDEFLERMGQLYECVLFTASLAKYADPVTDLLDKSGVFRSRLFREACVFHQGCYVKDLSRLGRDLKKTIILDNSPASYIFHPENAVPVQSWFDDMSDTELLSLIPIFEELSYSEDIYTSLGQLKAP | 144 |
W1NF27 | 5.1.3.3 | ACT_SITE 177; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 309; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1" | MAESKSTSHEPVPELFGLSNGTLQLKLTNWGATITSLLVPDSKGDLADVVLGFDSLEPYLKGASPYFGCIVGRVANRIKDGKFALNGEQYSLPINKPPNSLHGGERGFDKVAWEVLEKDHDETPSITFKYHSHDGEQGYPGDLNITATYSLPGPMTLRLDMESIPENKPTPISLAQHTYWNLAGHNAGNTLDHHIQLWGSHITPVDQYTVPTGEIMPVKGTPFDFLEEKKIGSRIHEVPGGYDHNYVLDCGEEKMGLKLVARLRDPSSSRVLTLWSNAPGVQFYTGNYVNGVVGKGGAVYGKHAGLCLETQGFPNAINQP... | 211 |
H2LEU4 | 2.7.10.1 | ACT_SITE 857; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000619-1" | MELLPRGARTLLPPLLLLLPPLLLLPPLLLLGLSRPVGAGDGRRVCQGTSNLLTLLGTREYHYESMVRMYSNCSVVLENLEITYTLENQDLSFLQSIQEVGGYVLIAMNDVATVPLVNLRLIRGQNLYDKFALLVMSNYHSNNITGAPRYTSGLRQLQLSRLTEILNGGVKVTNNPLLCNMEKIQWWDIVDKARNFSVLLKFDDYKRDCERCDPGCVNDSCWAAGPDHCQKFTKLVCAEQCGPGRCSGPKPLDCCNQHCAAGCTGPLATDCLACKNFNDDGICKDSCPPLNLYNHKSQQVVENPNAKYSFGATCVKACPH... | 97 |
P27932 | 3.2.1.1 | ACT_SITE 207; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:P00693"; ACT_SITE 232; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:P00693" | MGKQMAALCGFLLVALLWLTPDVAHAQTQILFQGFNWDSWKKQGGWYNMLKDQVGDIASAGVTHVWLPPPTHSVSPQGYMPGRLYDLNASKYGTKAELKSLIAAFHAKGIKCVADIVVNHRCADDKDGRGVYCIFKGGGPRGCLDWGPSMICCDDTQYSDGTGHRDTGADFAAAPDIDHLNPLVQRELSDWLRWLRRDVGFDGWRLDFAKGYSAAVARTYVQNARPSFVVAEIWNSLSYDGDGKPAANQDGQRQELVNWVKQVGGPATAFDFTTKGILQSAVQGELWRMRDKDGKAPGMIGWYPEKAVTFVDNHDTGSTQ... | 157 |
Q9SWW6 | 2.4.1.12 | ACT_SITE 358; /evidence="ECO:0000255"; ACT_SITE 726; /evidence="ECO:0000255" | MEASAGLVAGSHNRNELVVIHNHEEPKPLKNLDGQFCEICGDQIGLTVEGDLFVACNECGFPACRPCYEYERREGTQNCPQCKTRYKRLRGSPRVEGDEDEEDIDDIEYEFNIEHEQDKHKHSAEAMLYGKMSYGRGPEDDENGRFPPVIAGGHSGEFPVGGGYGNGEHGLHKRVHPYPSSEAGSEGGWRERMDDWKLQHGNLGPEPDDDPEMGLIDEARQPLSRKVPIASSKINPYRMVIVARLVILAVFLRYRLLNPVHDALGLWLTSVICEIWFAVSWILDQFPKWFPIERETYLDRLSLRYEREGEPNMLAPVDVF... | 70 |
Q54IF2 | 2.7.11.1 | ACT_SITE 296; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MLKDIYNSLLSKKQEESNMAAWNNEDILETQAQLFFSIKSIKGLKIMDNPIKVYCLASLEKQSVQTSSIVINKDQSQIEWNEGYTFDVISSKSILALSIWQGNANVTIANNSIEGGGSSNNSKLVGKLYIPFATFKKQFCDQWFPLTGTSQSVSIHVKTSFTNSSKKVTVDDFIFLRMIGRGAFGQVNLVKKIDTGRLYAMKVIKKDKCLNMNAVGHTFTERKLLKKYYHPFIVGLKYSFQTQDSLCMVLDYIGGGELFYHISERETFSEETARFYIGQIMLAIGFLHEHGVIYRDLKLENLLMDLDGNICLVDLGLCKE... | 99 |
A0A022QE50 | 1.11.1.7 | ACT_SITE 65; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAIITKLLFLCFLVFFFHHANAQNLALNFYRRTCPSVESIVNRTTASFISRAPSLAAALLRMHFHDCFVRGCDGSVLLNSTANNTAERDSIPNLSLRGFQVIDAVKTAVERSCPRTVSCADILALVARDAVSQIKGPFWQVPLGRRDGNVSISNEALTNLPPPFFNATQLVASFAAKGLDVKDLVVLSGGHTIGVSHCSSFTTRIYNFTGRNDADPTMDPNYVAALKARCPPTDTTTIVQMDPGSFDRFDTDYYTIVRKRRGLFESDAALLRNNVTNAYVQQHSSSSGSSSFFQDFAASMVKMGRIGVLTGTAGEIRRIC... | 14 |
A0A3B6RQL7 | 1.11.1.7 | ACT_SITE 69; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MRLAVVLLCALVAVQVALLAASSAEAGELVVGYYDKKCRGVENVVQWHVRRALKTNRRAGAALVRLLFHDCFVRGCDASVLLDASPENPHPEKEAPVNIGLAAFDLLEEIKAAVEDRCPGVVSCSDILIYAARDAAHALSNGNIHFDVPAGRLDGHVSSAAEAQAELPDSTFTVQQLIDNFARKDFDVEELVILSGAHSIGVGHCSSFTGRLTAPPEQINPAYRNLLNHKCHQGANPAVVNNVRDEDYETVSKFMPGFTSRVRKISDFLDNTFYHNNLARIVSFNSDWQLMTHTEARGHVHEYADNATLWDGDFADSLLK... | 14 |
A0A9J7L472 | 1.1.1.205 | ACT_SITE 404; /note="Thioimidate intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_03156"; ACT_SITE 523; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03156" | MSRRRRMAQAADMNRSDSERSTEDPTVTMTEEDSRCMADYLISGGTGYVPDDGMTASQLFGTGEGLTYNDFLILPGFIDFTAEEVQDLQLQVCGSQRVATNAPSILASIESPCTPNCPVHTEDLTSAMTKKIQLKAPLVSSPMDTVSESDMAIAMALTGGIGIIHSNCTPEFQANEVRKVKKYEQGFIMDPIVLSPEHTVGDVCEMKRKHGFSGIPITENGKLGGKLLGIVTSRDIDFMNSDHHHIKLRDVMTPFEELVVGHAGVSLKEANETLQRSKKGKLPIVNENDELVSLIARTDLKKNRDYPLASKDSKKQLLCG... | 3 |
A0A7M7P2S5 | 3.1.3.48 | ACT_SITE 461; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR000929-1" | MASRRWFHPNISGMEAEQLLLNNGFDGCFLCRPSKSNPGDFTLSVRRNGEVTHIKIQNTGDFFDLYGGEKFATLAELVQHYTEGRNQLKERNGQMIELKYPLNCADPTNERWFHGHITGKEAEKSLVDKGKNGSYLVRESHSKPGDYVLSVRTEDKVTHVMIRCQDTKYDVGGGEQFETLTDLVDHYRKNPMVETTGYVVHLKVPFNATRISASGIRNRVEVLEKETKSRENSKKAGFEEEFEALQLLDNKHLLPRKIGDKAENKSKNRYKNILPFDHSRVIINDGLPGDYINGNYIDLPKAWKNSIELQQQGENVEKID... | 149 |
A0A8J1MGE9 | 2.7.10.1 | ACT_SITE 1203; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000617-1" | MVHAKMLVAVPVALLFLSLLPQCMGQCEEAAKMAEMDLNLKLNLQNFTTDTPIQNIIMFKGYVYVGAVNKIYVLNENLTKISEYKTGPLLKHSDCLPCKNCTDNLLSPNGTWKDSVNMALFVEDFYDDQLISCGNIRKGECQRHTLHSDKPWDIASDVHCLYSSQMVEDKDSCPDCIVSTAGSKILVTVGDRFVKFFVGSTLTGQPSTIHSVSVRRLKETQDGFEYLTDQSYIDVLPHLRDIYPIRYIYTFESNNFVYFLTVQRESLDSQAYHTRIVRICSSDSELRSYIEMPLECIFTEKRRKRSTASAVFNIVQAAYL... | 97 |
Q5AP53 | 2.7.11.1 | ACT_SITE 458; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MNFDQLTDEQKQQLYLQHLQQQQQLQQQQQQLQQQQHQLQQQQQSYHLQQQQAAYQQQNQAQLQQDDSYMDEDTSELINQPPVQLDHGSPIRQQPQMSAFMPSPRFAQSESFDNHLNVDPNNTERFTSMDSMNFQPPASTFTQLGNGSSTNLSEISSGQNSLLSNHSVNNLPTALTSDTSPPVQQHPQFQPQQQQQQQQPQQQQIFQQQQQQQQQQQQPQQSRAVVNQSVSTEAANSDMTGSNTKYVYFERKPNLLSKTTQDKAASIKLTLENYYTSSVSHAIERNQRRLELENKIANEDIGSSEERKNRQLQNLGKKES... | 99 |
Q4WFZ3 | 2.3.1.286 | ACT_SITE 203; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037938-1, ECO:0000256|PROSITE-ProRule:PRU00236" | MGHLTRIFIETYEICEKYDNPFKDFKLPSSSSMDDDSLPNVGLPDAQTGLPCLKTQAPPAVNNNHHQYIEAFRSDKMTDIENIANLIKSGQVHKIVVLVGAGISTAAGIPDFRSPETGIYDRLKPLHLPYPEAIFHINYFRHTPEPFYAIARARHPRSLKPTITHAFLALLEKKGLLHFVFTQNIDGLERDVGIPEDKILNAHGSWRTQRCWKCKTPYPDDLMKQAISTGTVPYCQVPDCGGAVKPDIVFFGQPLPAEFDEKEKEVSEADMMLVMGTSLKVAPCSRLPRLAREGIPRVLVNREKVGDFGKRAEDVSILGD... | 58 |
Q9KPB1 | 3.4.21.89 | ACT_SITE 90; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"; ACT_SITE 145; /evidence="ECO:0000256|PIRSR:PIRSR600223-1" | MANTFSLILVIVTLVTGIVWTLEKLVWAKKRQQKQAHLQAQTPDMPASALDKVVAQPWWIENSVSIFPVIAFVLVLRSFIYEPFQIPSGSMMPTLLVGDFILVEKYAYGLKDPVWRTQLVETGKPERGDIVVFKYPVNPEIDYIKRVVGMPGDTVRYSAGKELCIQHQGESECQAVKLSNVQESEFYQNEIPLIQLNEQLGKVEHNILVNPLSIDNVANYRPRSGVNEWVVPQGHYFVMGDNRDNSADSRFWGFVPEQNLVGKAVAIWISFEFERAEDSVLPRWIPTGVRFNRVGGIH | 178 |
P50382 | 4.2.1.20 | ACT_SITE 37; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00131"; ACT_SITE 48; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00131" | MEMGKMLVVYMTLGYPNVQSFKDFIIGAVENGADILELGIPPKYAKYDGPVIRKSYDKVKGLDIWPLIEDIRKDVGVPIIALTYLEDWVDQLENFLNMIKDVKLDGILFPDLLIDYIDDLDKIDGIIKNKGLKNVIFTSPSVPDLLIHKVSKISDLFLYYGVRPTTGVPIPVSVKQLINRVRNLVENKLIVGFGLSSESDLRDALSAGADGIAIGTVFIEEIERNGVKSAINLVKKFRAILDEYK | 202 |
A0A6P9EPR1 | 1.1.1.100 | ACT_SITE 228; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR611284-1" | MAAAAIAFSSTGAPAKLSQFSRLRPPIFASLRLPRLSSHFGFGTSSSSSDCASCCAGLRAQVAAVEQPSVGVAQNVEAPVVVVTGASRGIGKAIALNLGKAGCKVLVNYARSSKEAEEVSKEIEACGGQALTYGGDVSKEGDVELMIKTAVDAWGTIDVLINNAGITRDGLLMRMKKSQWQEVVDLNLTGVFLCTQAAAKIMMKKRKGRIINIASVVGLVGNAGQANYSAAKAGVIGFTKSVAKEYASRNINVNAVAPGFIASDMTGKLGEDIEKKILQTIPLGRYGQPEEVAGMVEFLALNPAASYITGQGFKYVYVLL... | 2 |
A0A061FGX9 | 1.11.1.7 | ACT_SITE 74; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MTFLTSKMHKHTLVALIWALLILPNILGVSQGQLGVGFYSKTCPTAESIIHKVVQKAVADSLRNAALLLRLQFHDCFVEGCDGSILIKNVADGELKARGNLGVQGFDIIESAKARLENLCPGVVSCADIVALAARDAVSLVKGPFYDVPTGRRDGRLSRMSLAENLPDVDDSIHVLKSKFRAKGLSDKDLVLLSGGAHTIGLTACFFMQHRLYNFTPGGGSDPAINPRFLPQLKAHCPLNGDVNVRIPLDWATQNVFDVHILRNIRDGTAVIASDARLYDDRETRQILDSYISSNGSGTRPSFNADFAKAMVKMGNIGVK... | 14 |
P0CS16 | 2.3.2.23 | ACT_SITE 88; /note="Glycyl thioester intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000255|PROSITE-ProRule:PRU10133" | MSTAAKRRLIRDFKRLTSDAPIGISGSPNPDNIMVWNAVIFGPPETPFEDGSFRLTLTFTDAYPNKPPTVRFISKMFHPNIYANGELCLDILQNRWSPTYDVAAILTSVQSLLNDPNPASPANVDAAQLFKENLKEYERRVKKTVELSWVDNADEIEAEVVEADEGSSS | 64 |
A0A287B3S7 | 2.7.11.1 | ACT_SITE 170; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037993-1" | MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKVYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSIAGAAVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEALARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLRDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRVFFRRRVSPECQQLIQWCLSLRPSERPSLDQISAHPWMLGAEEEGTPESRDLRLCALDTDDGAST... | 99 |
A0A251S7C0 | 1.11.1.7 | ACT_SITE 63; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MRFDAIMKVVVMLVIMLRHCNGLSMNYYMLSCPMAEFIVRNSVNSALRADPTLAAGLLRMHFHDCFIEGCDASILLDSTDDNTAEKDSPANLSLRGYEVIDDAKQQLENQCPGVVSCADIVAMAARDAVLFSAPGLIYDIPKGRKDGTRSKIEDTRNLPPPIFNSSELIKMFGQKGFTAQEMVALSGGHTLGVARCSAFKNRLKNFDSTHDVDPNMDTQFMKTLVKTCSAGDTAEQPFDATRNNFDNAYYRALQRQAGLLTSDQTLMTDPNTRPIVNAYAMNQAMFFFDFQRAMVKMGQLDVKETGQVRQNCRKIN | 14 |
A0A072U0A6 | 3.1.1.11 | ACT_SITE 424; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MSSFKAYGKVDESAQAMFEVRRKSRKRITIICLSTVVLIGIVFAAVFGTIAHNNARNDDNNNNENDNNDQSLSSAIKAVCDVTLYKDSCEKSLSPLVQPGQQIRPEELFKLSIQVALTAVSKGVEYLSDHATFNDLNLNLDNRTKEALINCKDLFGLAVDDLNSSLSYGGKSSLLDVLEDLETWLSASGTYQQTCIDGLEQAEEALKSSITTNLKNSTEFTSNSLAIITWLNKAASSVNFRRLLSLSHQNEEPNWLHHKDRKLLQKDSDLKKKADIVVAKDGSGKYKTISAALKHVPNKSDKRTVIYVKKGIYYENVRVE... | 125 |
Q556Q3 | 2.7.11.1 | ACT_SITE 1074; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MNFNFEQILEYNFDFKKLHKNKLKNNNLSENEDDYATTVIECLIHLCEVIPTNKIYSGANKFISCFYEFMNERFIETLVLEFYDLMTTDNSKVTTGIFDQFFSLIKKSDIIYKSFYEWDSNILENRFIFKNNNNNIDGDDDDGNEDDYFGRFSILSILEDDNSHIISNYFKFTNYERLEDLWIMICHYQATDIAKALFNLYYDSKEDCISVFASDDNNNKISISILRILEITSIEFSLPVLTVIVENTPNFLNSIPTKTSMLGMKFKLHNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNINKNNNDNGNGKAE... | 99 |
A0A6P9F1E6 | 2.3.1.286 | ACT_SITE 267; /note="Proton acceptor"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00236" | MIQPETVDDKKDEENNSDNHIVLVLRRQWLLRAVANDHFIKDKYFTCGEKLVCNECSVTVVPLILYEPMGSLGSIWMGPAYIAAVVFFLTGMGECYGPPISLKARGMQIAASDPWLLGSPQYYTSIPHSQSVTISLGYAEKLSYIEDVGKVGMAEYFDSPYILQEKIERLAMMIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQREGQALPEASLPFHRAMPSLTHMALVELEKAGILKFLISQNVDGLHLRSGIPREKLAELHGNSFMEACPSCGVEYLRDFELETIGLKETSRRCSDVKCGAKLKDTVLDWEDAL... | 58 |
Q9UTE2 | 1.3.3.3 | ACT_SITE 118; /note="Proton donor"; /evidence="ECO:0000250" | MSDITVEPIGKQMEKLILDVQQEIVAGLEAVDGQKFFQDKWTKGEGGYGISCVIQDGNVFEKGGVNTSIVQGKLNQDAVQRMRANHEGIDRTAKELPFFAAGISMVIHPRNPMAPTTHLNYRYFELVNSDGKKIWWFGGGADLTPSILFEEDGKHFHKLHKEACDRHDPTFYPRFKKWADEYFLIKHRKETRGIGGIFFDDLSEKDPQELFAFVKDCAHTFLPAYVPIMEKRKNMEFTEDDKEFQLIRRGYYAEFNVMYDRGTWFGLQAPEPRVESILMTLPLHASWRYKYEPKQERHKALLKVTHTPIEWC | 27 |
Q8A1R1 | 3.2.1.52 | ACT_SITE 304; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR625705-1" | MKLLLTTLAIVYLSLFMSLQAQEQVRVIPYPAEVTMQAETCKLKSGQKIHYLDASLYKEAAFLEKKLADLNYKMKVIPGKKAVKGINLSLNNRLQNKEGYQLIIAPKQVLIKGGSPAGVFYGIQTLLQQLTNGDLRCGTIEDAPRYEWRGYMLDEARHFSGEKRVKQILDLMAYYKMNRFHWHLTDAQGWRIEIKQYPKLATIGGEGCHSDPDTPAQYYTQEQIRDIIAYAKERHIEIIPEIDMPGHATAANKAYPEYSGGGTEEHPEFTFNVGKEETYTYLTNILKEIAALFPSPYLHIGGDEVAYGIKAWETDPHVQA... | 170 |
A0A3B6BA24 | 1.11.1.7 | ACT_SITE 80; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MASSGAMVLAMMGLLAALVCPAAAAAAGFISMPTDNVGDHSYGVHATFCPNLEKIVLDKVAEARRWDIGVVAGLLRIFFHDCFPNGCDASLLLEPSHLYSSERARERPQNQGLHQGALDLIQRIRDAVRDAKCTEVSCADITMLATRQAIKLSGGPDYGVQLGRKDSIDPARIDQVNQFLPAPDAKIWKLIEVFQSRGFDRTDLAALSGAHTIGKTSCPNLASRTGDAAWFVEAIKMNCPGSWDKKQVLDVDTPDDFDHKYYKNIVDGKGVLSTDMELLNDPFIKDLVHKWATDKNFFFWKFGEAMAKMARLPVGGPSEY... | 14 |
D6WYJ4 | 2.3.2.26 | ACT_SITE 882; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR001569-1, ECO:0000256|PROSITE-ProRule:PRU00104" | MSNAPTSRRNGAQKIRLTILCARNLVRKDLFRLPDPFAKISVDGSGQCHSTEFVKNTLEPKWNSHYDLYIGRNDSITISVWNHRKVIKKQGSGFLGCVRIVNSHIQRLRDTGYQCLDLGKACPADSEPVKGQIIISLLSRDGPCSGTPLAVVGPQGELRGPTDRDSSPSNNDDLPPGWEERRTENGRPYYVNHITRSTQWIKPQSTNKTRRRSTHQNDNNNTNNENTIGGTQMGVQEILNNNTGETLTPSSSTSPVSPVVSPQKTTSTPQTTDNRNNFITLSPTSTSVIPAPNNISCNAPNGENTNVVSPQMGQGQGQRA... | 65 |
Q8LG98 | 3.4.19.12 | ACT_SITE 89; /evidence="ECO:0000250|UniProtKB:Q96DC9"; ACT_SITE 92; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q96DC9"; ACT_SITE 259; /evidence="ECO:0000250|UniProtKB:Q96FW1"; ACT_SITE 288; /evidence="ECO:0000250|UniProtKB:Q96DC9" | MQNQIDMVKDEAEVAASISAIKGEEWGNCSSVEDQPSFQEEEAAKVPYVGDKEPLSSLAAEYQSGSPILLEKIKILDSQYIGIRRTRGDGNCFFRSFMFSYLEHILESQDRAEVDRIKVNVEKCRKTLQNLGYTDFTFEDFFALFLEQLDDILQGTEESISYDELVNRSRDQSVSDYIVMFFRFVTAGDIRTRADFFEPFITGLSNATVDQFCKSSVEPMGEESDHIHITALSDALGVAIRVVYLDRSSCDSGGVTVNHHDFVPVGITNEKDEEASAPFITLLYRPGHYDILYPKPSCKVSDNVGK | 175 |
B9N6K4 | 3.2.1.52 | ACT_SITE 338; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1" | MTSNLVISSRCSLFLTLFYLLVSASLTATSAQWVWPKPRTLSWPIPLATILSPNFTISSPYHQHLSPAVNRYRLQILTEHHLPLVPPPFNLSNSSPPLQALTITVKDLAAPLQHSVDESYALAIPTASSTANLTAETVWGAMRGLETFSQLVWGLKPLLVPVGLDVWDSPLFEHRGIILDTSRNYYPVDDILRTIKAMSANKLNVFHWHITDSHSFPLVLPSEPALADKGSYGNDMLYSPADVATIVRFGLEHGVRVLPEIDSPAHTGSWAEAYPDIVTCANMFWWPAESKWADRLASEPGTGQLNPLNPNTYQVLKNVI... | 170 |
K7VXP1 | 3.2.1.14 | ACT_SITE 133; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001060-1" | MARQLFLHPVLLAAACLLVSVVLCNAGVAQAAWWWPRWDSLFPSRGQQQHHGGYDYHDNGDGSSKSRVASIVTQELYGEMFKHKDDAACPAHGFYTYASFLAAAARFPEFGGDGDLATRKREVAAFLAQVSHETTGGWATAPDGPFAWGLCFKEEITPPIDYCDASSTQWPCVAGKSYHGRGPIQLSWNFNYGPAGQALGFDGLGSPDVVAADPEVAFKTALWFWMTPRAPKPSCHDVMVGRYRPSAADVAANRTAGYGLTTNIINGGIECGKSGVPQVDDRIGFFREYCKLLRVDVGTNLDCAQQQPYSS | 158 |
Q8ZJL6 | 2.7.1.11 | ACT_SITE 129; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00339" | MVKKIGVLTSGGDAPGMNAAIRGVVRAALSAGLDVFGIEDGYLGLYENRMKKLDRYSVSDMINRGGTFLGSARFPEFRDPEVRKVALKNMHERGIDGLVVIGGDGSYAGADLLTKEGGIHCVGLPGTIDNDVAGTDYTIGFFTALETVVEAIDRLRDTSSSHQRISIVEVMGRYCGDLTLAAAIAGGCEFIAIPEVEFKRDDLVAEIKAGIAKGKKHAIVAITEKLDDIDSLAKYIEKETGRETRGTVLGHIQRGGAPVAYDRILASRMGAYAVDLLLQDHDYKKGGFCVGVQNEKMVHELISVCIAPENKKSKFKEDWY... | 84 |
P77972 | 4.2.1.11 | ACT_SITE 211; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00318"; ACT_SITE 341; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00318" | MLSKVPATIEEIAAREILDSRGRPTIEAEVRLESGAHGIAQVPSGASTGSFEAHELRDGDPKRYDGKGVEKAVRNVTEKIAPVVEGLDAFDQMAVDQAMIDRDGTDNKKELGANAILGVSLATAKAAAAELAIPLYRYLGGPLANVLPVPMMNVINGGAHADNNVDFQEFMIMPVGAETFKEALRWGAEVFAVLGKVLKERKLLSGGVGDEGGYAPNLTSNQQALDILIEAIEQAGYKPGSQIALAMDIAASEFFKNGQYEYDGGSHSPQEFIDYQAKLVSQYPIVSIEDGLHEDDWESWKGLTTSLGTKTQLVGDDLMV... | 200 |
A0A5F5PZ83 | 3.2.1.23 | ACT_SITE 278; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR006336-1"; ACT_SITE 352; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR006336-1" | MCRRPGSVPLAAQSPRPSPWRCPAGPGCVPRLPRGGGSSARPPLLQPVGMASRPRSSPCLFWKRILCIFFLPCILSGFSPRVKHKKNLLSGKAQPQLSQYRFIWSRLTPLELRNRSMGLQTESRVGSNPYFTLEGHKFLIFGGSIHYFRVPREYWRDRLLKLKACGFNTVTTYVPWNLHEPERGRFDFSGNLDLEAFVLTAAEIGLWVILRPGPYICSEIDLGGLPSRLLQDPQVNLRTTDKGFVEAVDKYFDHLISRVVHLQYRKGGPIIAVQVENEYGSFYKDKDYMPYLQQALLKRGIVELLLTSDNVDDVLKGYIK... | 163 |
A0A8M2BEF6 | 2.1.1.37 | ACT_SITE 1298; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016" | MATNVSLEPNNPDDKCSRYEVLGWINETLQTNFTQVEQCRSGACFCQLIDLLFPGTINLKKVKFESQKRSDFMQNYGLLQAAFRDLEVTEPVPVNELLSGKFRPNFTYLKWFKKFFYANVKQERVYNAFEARDGQEIVPVDDVMKSPKALKSSYESGRAGEESDMEINGGRRSATYDPKWQRNLKWIRASDMGDNYAYCTTCDYNIILLAGFHDLKRHQLTQNHMKHETGRTNLPGRKQIEESISCSETMLLFIQSHCLSSLPSRINRVSQRTARCILGLKYPNDIVSACKLNPYCIYIYGQVPLDVKTGDKTNCHVVLA... | 47 |
P52409 | 3.2.1.39 | ACT_SITE 123; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:O22317"; ACT_SITE 265; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:O22317" | MPLLILLMLLAAGAAGAESATPSLHIGVNYGANADNLPSPTSVATFLATKTTIDRVKLFDANPTFISAFAGTPISLAVSLPNSALPALADKATGLDAARSWIRANLSPYVPATNVTLLLAGNEILLSTDTNLILSLLPAMRRLAQALKAEGLTGVRVTTPHYLGILAPSDGIPSNASFRAGYNTKLFPAMLQFHRDTGSPFMVNPYPYFSYRPETLNYALFRPNSGIYDPATKLNYTSMLDAQMDAIYTAMKKLGYGDVDIAVGEAGWPTQAEPGQIGVGVQEARDFNEGMIRVCSSGKGTPLMPNRTFETYLFSLFDEN... | 167 |
Q8A0U2 | 5.3.1.1 | ACT_SITE 96; /note="Electrophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00147"; ACT_SITE 167; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00147" | MRKNIVAGNWKMNKTLQEGIALAKELNEALANEKPNCDVIICTPFIHLASVTPLVDAAKIGVGAENCADKASGAYTGEVSAEMVASTGAKYVILGHSERRAYYGETVAILEEKVKLALANGLTPIFCIGEVLEEREANKQNEVVAAQMESVFSLSAEDFSKIILAYEPVWAIGTGKTASPEQAQEIHAFIRSIVADKYGKEIADNTSILYGGSCKPSNAKELFSNPDVDGGLIGGAALKVSDFKGIIDAFNA | 213 |
A0A8V0ZLR3 | 3.1.1.4 | ACT_SITE 100; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 144; /evidence="ECO:0000256|PIRSR:PIRSR601211-1" | MKLLVLLVCREYPLHGDGARLGLMAPLFSPFLEGSLSNANNSISPVAVLAPAGCNIAQFGIMIKEKTGKPALSYNGYGCHCGLGGSKYPVDATDWCCHAHDCCYKRLSSVTCVPHLATYKFSIKRGQITCGSGSSCQRAACECDKKAAECFKRNLRTFNKSYQNYLNFKCKGSRPSC | 130 |
A0A5F7ZJF7 | 3.1.1.4 | ACT_SITE 88; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 133; /evidence="ECO:0000256|PIRSR:PIRSR601211-1" | MGPLPVCLPIMLLLLLPSLLLLLPGPGPRSGEASRTLHMQRRGILELAGTVGCVGSRTPIAYMKYGCFCGLGGHGQPRDAIDWCCHRHDCCYTRAEEAGCSPKTERYSWQCVNQSVLCGPAENKCQELLCKCDQEIANCLAQTEYNLKYLFYPQFLCERDSPKCG | 130 |
Q8A6N4 | 6.3.4.4 | ACT_SITE 13; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00011"; ACT_SITE 41; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00011" | MKVDVLLGLQWGDEGKGKVVDVLTPKYDVVARFQGGPNAGHTLEFEGQKYVLRSIPSGIFQGDKVNIIGNGVVLDPALFKAEAEALEASGHPLKERLHISKKAHLILPTHRILDAAYEAAKGDAKVGTTGKGIGPTYTDKVSRNGVRVGDILHNFEQKYGAAKARHEQILKSLNYEYDLTELEKAWMEGIEYLKQFHFVDSEHEVNNYLKDGKSVLCEGAQGTMLDIDFGSYPFVTSSNTVCAGACTGLGVAPNRIGEVFGIFKAYCTRVGAGPFPTELFDETGDKMCTLGHEFGSVTGRKRRCGWIDLVALKYSVMING... | 253 |
B9RT91 | 3.1.1.11 | ACT_SITE 415; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MAYGYDNGSVAEAAARKKKFAVIGVSSIILVAMVVAVAVGVNDGKEKGGESSPLSGSSGQLSTSTKSIQAICQPTDYKQTCEDSLNKAAGNTSDPHKLVQAGFQVAIDALKVAIENSTTLKEVAKDPMAKQALDNCKELMNTAISDLKTSFQQVGDFDISKLDEYVANLKIWLSATITYQQTCLDGFDNTTGPAGQKMKEILSTSSQLTSNGLAMVTGLSSILQDLDLSGLTGRKLLAQGNDNFPSWLSPAKRRLLAQTPATIKPNMVVAQDGSGQYKTINEAIKNIPKSGNSTFVLYIKEGVYKEVVTFSRSLTHIMLI... | 125 |
P06720 | 3.2.1.22 | ACT_SITE 174; /note="Proton donor"; /evidence="ECO:0000250" | MMSAPKITFIGAGSTIFVKNILGDVFHREALKTAHIALMDIDPTRLEESHIVVRKLMDSAGASGKITCHTQQKEALEDADFVVVAFQIGGYEPCTVTDFEVCKRHGLEQTIADTLGPGGIMRALRTIPHLWQICEDMTEVCPDATMLNYVNPMAMNTWAMYARYPHIKQVGLCHSVQGTAEELARDLNIDPATLRYRCAGINHMAFYLELERKTADGSYVNLYPELLAAYEAGQAPKPNIHGNTRCQNIVRYEMFKKLGYFVTESSEHFAEYTPWFIKPGREDLIERYKVPLDEYPKRCVEQLANWHKELEEYKKASRID... | 162 |
P76237 | 2.7.7.65 | ACT_SITE 425; /note="Proton acceptor"; /evidence="ECO:0000255" | MKLHHRMLRHFIAASVIVLTSSFLIFELVASDRAMSAYLRYIVQKADSSFLYDKYQNQSIAAHVMRALAAEQSEVSPEQRRAICEAFESANNTHGLNLTAHKYPGLRGTLQTASTDCDTIVEAAALLPAFDQAVEGNRHQDDYGSGLGMAEEKFHYYLDLNDRYVYFYEPVNVEYFAMNNWSFLQSGSIGIDRKDIEKVFTGRTVLSSIYQDQRTKQNVMSLLTPVYVAGQLKGIVLLDINKNNLRNIFYTHDRPLLWRFLNVTLTDTDSGRDIIINQSEDNLFQYVSYVHDLPGGIRVSLSIDILYFITSSWKSVLFWI... | 120 |
Q9S972 | 2.7.11.1 | ACT_SITE 648; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MRNVPNYHHSYFILFIIILFLAFSVYASNFSATESLTISSNKTIISPSQIFELGFFNPDSSSRWYLGIWYKIIPIRTYVWVANRDNPLSSSNGTLKISDNNLVIFDQSDRPVWSTNITGGDVRSPVAAELLDYGNFVLRDSKNNKPSGFLWQSFDFPTDTLLSDMKMGWDNKSGGFNRILRSWKTTDDPSSGDFSTKLRTSGFPEFYIYNKESITYRSGPWLGNRFSSVPGMKPVDYIDNSFTENNQQVVYSYRVNKTNIYSILSLSSTGLLQRLTWMEAAQSWKQLWYSPKDLCDNYKECGNYGYCDANTSPICNCIKG... | 99 |
C5XTQ1 | 3.1.1.11 | ACT_SITE 417; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MATFGRARPALPVIAWSCAMATALALATVMPVTSGKEDEAAAVSTIAAASPASTTNVTLLCRSTPYPRACETALTSAEARSARGPFAASVQFAMARATTTRALARNLSSSAAAPAPPAPSSGMHDCAELLGISLAQLRDALAGSAADADGATTWLSAALTNQGTCRDSLAAVPLPDDPAGSDAVRRQVAALARFISTALALHVGKVKKGETAAAAAGVPPSREGTAFPSWLSENDRKLLESLSPATTNDIVVTPDAVVALDGSGTHTSINEAIAEVTAEVDTEASGGRGVGISRRRKVIHVKAGRYEESVSISYQQADVM... | 125 |
Q94981 | 2.3.2.31 | ACT_SITE 304; /evidence="ECO:0000255|PROSITE-ProRule:PRU01221" | MDSDNDNDFCDNVDSGNVSSGDDGDDDFGMEVDLPSSADRQMDQDDYQYKVLTTDEIVQHQREIIDEANLLLKLPTPTTRILLNHFKWDKEKLLEKYFDDNTDEFFKCAHVINPFNATEAIKQKTSRSQCEECEICFSQLPPDSMAGLECGHRFCMPCWHEYLSTKIVAEGLGQTISCAAHGCDILVDDVTVANLVTDARVRVKYQQLITNSFVECNQLLRWCPSVDCTYAVKVPYAEPRRVHCKCGHVFCFACGENWHDPVKCRWLKKWIKKCDDDSETSNWIAANTKECPRCSVTIEKDGGCNHMVCKNQNCKNEFCW... | 67 |
H3GAK2 | 3.1.1.11 | ACT_SITE 200; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MQTFALPLLALAGLAATVSTADVVCNGTDARTVPPTGAIVVDPTGAYNGSFHNISEAVANIPNTTDEHTLFFFPGVYHEQVLVSKLRGPLVLQGYTCNTTSYVDNQVTITQAKAQKDIPPEITSGRNDLTSTLRLKTNKVKVYNLNVANTAGNVGQAVATIVEGSDYGFYACNLTSYQDTLYANKGRELFAKSYISGAVDYVFGSKAQAWFESCDFETIGKGCITANGRTNETNPSYYVFNKARVFGTSGNGTAYLGRPWRTFARVVWQNSEFSDIINPEGWQRWNNDNNTANVYFKEFNNTGAGAALDKRVAFSGLLNA... | 125 |
Q5A1Q0 | 5.1.3.15 | ACT_SITE 159; /evidence="ECO:0000256|PIRSR:PIRSR016020-1"; ACT_SITE 264; /evidence="ECO:0000256|PIRSR:PIRSR016020-1" | MPVEELEDRVIITDPNDSTNRATILKFGATVVSWKNNNQEKLWLSEGAHLDGSKAVRGGIPLVFPVFGKQKDSNHPTFKLPQHGFARNSTWEFLGQTQESPITVQFGLGPENVDPETLKLWNYDFTLILTVSLTKDKLVTSIDVENTGKEAFEFNWLFHTYYRIHDITDTLVTNLIDQQCYDQLIGESYIEKAPVISFHEEFDRIYSKVSLEKSIQVVDKGQVLFNLHRKNLPDSVVWNPWTKKAEGMADFQPKSGFHQMVCVEPGHVNSMVSLPAGGKWSGGQEITIGGEIKVQANIY | 210 |
W5NA14 | 2.7.10.1 | ACT_SITE 1040; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | RIKASVEGLLSQYTISFPLFSASTLKYMPDPPKLSISDKVYKINATDTLELTCRGQHHLEWTWPRNESGTEQGLSVVDCSGSGLFCKTLVLVKATANDTGEYRCSYRSLPVNQGKTSASIYVFVQDYRSPFVSSSPNFEFVFIREASPVVIPCLGSIEDLSVTLYTNYPRKEFFPDGKTIYWDSRQGFTIPSRFISSAGVAFCQTIIQNETFQSSLYIFAVVGYRIHELSLTPKYQVKLAVGEKLLLNCTATTELNVGIDFQWKYPAWKKSVGARQKENRSEIKPYKKKLRDCLELSSTLIIEHVTLNDTGEYICTASSG... | 97 |
F4P276 | 3.5.1.2 | ACT_SITE 89; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR005639-1"; ACT_SITE 197; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR005639-1"; ACT_SITE 199; /note="Charge relay system"; /evidence="ECO:0000256|PIRSR:PIRSR005639-1" | MDQAKPLRIGVLALQGAFSEHINILNRMSQWVDMAIPIRTKEQLENSCLDALILPGGESTAIALAAERNGLMEPLRQWVRSGNPIWGTCAGMILLSDTAQGTKEGGQELIGGLHVQVKRNAFGHQLDSFVECIDIPVIGDTPFQAVFIRAPLISSICVDEMAKHVTTAPVQILARVPSKDNCIVAVQQGNILATSFHPELTQDTRFHQYFVKFSQEIVLNKLKDQEYISSLCF | 181 |
A0A3B6B920 | 1.11.1.7 | ACT_SITE 87; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MLAMLGLVAALLSYPTALSMAEASLISMPTEDVHRGHAPVVFLAESLTPDYYADSCPDVRGLVRSAVGEALQKDIALAAGLIRLFYHDCFPQVHMHTYISTSMCPETDSQGCDASILLAGAESELQMWPNRFLQRAAVQLIEDIRIKVHHACGPVVSCADIMALATHDAVLKLIEAFESRSLDVTDLVALSGAHTIGGAHCTSYADRFAGEANSNEFVRMLLHNCTTGDIRDKQDLDVTTPNKFDDKYFGNLEAGKGVLNSDMQLLHDPRAMELVKGIAENQWWFWNQFDTSIRKLGQLQGPQGNAGEVRTISCSVPNHK... | 14 |
G1K941 | 2.7.10.1 | ACT_SITE 696; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR620777-50" | MGARPRTRRRTEAPLWWGLGCLVLLGGWRAPLASASACPAPCACSPERIWCSEPAPSLRSFPVLGKRSEREKIADIYIANQRQLESINEIDVGLYTGLKNLTVVDSGLKFVSRQAFLKNTNLQYINLSRNKLSSLSRKSFRHLNLSDLILEGNPFKCSCDIMWIKVFQESKNPKTETQDFYCMNDNNQRISLMEKPVPNCGLPSVKLSTHNFTVVEGGSITLYCDASGSPPPSISWLFNNIASKYESDTNKNPASLTIKNVFSNDSGVQISCVAENSVGEDQDSVDLAVFFPPNITFLEVPYPDHHWCIPFSVRGNPQPT... | 97 |
A0A1D8PSA6 | 3.5.1.98 | ACT_SITE 149; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037913-1" | MYQELPFDELKVDPRKRRVAYFYDQDVGNYFYGTGHCMKPHRIRMAHSLIMNYELYKKMEIYRAQPATNLELTQFHTDEYIDFIDRVTPDNLHLFEREQVIFNVGDDCPVFDGLGEFCKISCGGSMEGAARLNRGQADIAINYAGGLHHAKKSEASGFCYTNDIVLGIIELLRYHPRVLYIDTDVHHGDGVEEAFYTNDRVMTCSFHKFGEFFPGTGNLTDIGIGKGKYHAINIPLRDGIDDASYKSIFEPIITKIMEWYQPSAIVLQCGGDSLSGDRLGPFNLSMRGHANCVNFVRSLGVPMMVLGGGGYTIRNVARTW... | 184 |
E3JRS9 | 3.4.21.92 | ACT_SITE 148; /evidence="ECO:0000256|PROSITE-ProRule:PRU10085"; ACT_SITE 173; /evidence="ECO:0000256|PROSITE-ProRule:PRU10086" | MGSVRKSNLLNGVLKSAIASPGNHFNATRRPSSLLSQPRRMLSDFHRLKGSGLVPMVIEREGRGGERAFDIFSRLLRERVIFVGGEINDADANLIVAQLLYLEAESPDPIELYINSPGGSVTAGLAIYDTMQYVRSPVHTICIGQACSMGSILLGAGAKGFRKALPNSTIMIHQPSGGSSGQASDMAIRANEILRLKKRLIEIYAKHCGKEDESQTDRCNRFEQALERDKFMDGESAQAFGIIDQVVASRSSKPNDN | 179 |
W5MBG9 | 3.1.3.1 | ACT_SITE 113; /note="Phosphoserine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR601952-1" | MAPLHFLLLGLQIYLAINPSYSVIPVAEEDPRFWNRKGRQALEEALELKPNAGKAKNLILFLGDGMGVSTVTATRILKGQLEGTYATVLCSCVQTLLHVSLLTYNVDHQAPDSAGTATAYLCGVKANYGTVGLSAAARRYQCNTTKGNEVTSILHRARKAGKSVGIVTTTRVQHASPAASYAHSVDRNWYSDSDLPHDALAGGCADISFQLIHNSDINVILGGGRQYMTPNGTKDPEYSSASARGKRQDGINLIDKWVKTKTSGNKKAVYVWNKTEFDAVNENDTEYLMGLFEPKDTRYELDRNKTQDPSLTEMTEKAIK... | 141 |
Q9UHD2 | 2.7.11.1 | ACT_SITE 135; /note="Proton acceptor"; /evidence="ECO:0000305|PubMed:23453971, ECO:0000305|PubMed:23453972, ECO:0000305|PubMed:30842653" | MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAETSDILHRMVIHVFSLQQMT... | 99 |
T1G579 | 3.1.3.16 | ACT_SITE 109; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR620405-1" | MKVILDGYPQHSPPIHPTKLTDQLYIGNQDNADDVILLQGLEITHVLNCAGTRNFDLTRSPYPLSSGITNFLMIPAQDYDEFDIMQFFEDAIGFLDSATLSGGRAFVHCSIGVNRSGAIVAAYMMISQKKRLLDVIVELKAKRLLILCNMGFRKQL | 144 |
A0A1U8AHV5 | 3.1.1.11 | ACT_SITE 422; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MNTYEMLGSRYVSHQRKKSMLWGCSLSLLVVAIVAFSCVTIIRSSGGEGGVVQPKPTKPRTSVVSRAVVSTCKDTLYRELCESSLRLSSTDAPPKTSGEVFDLSVKLAISQAESARSLAFSLSLVRQKQGTTHHYSITAMDDCIELLDDSLDHLNNVLDPKKNPSPNDIQTWLSAALTNQDTCLESLQNYKFSTEKDMMDGHAKNLSQLISNSLALYKTTKRIKDAKIPNLGGGGGGGGRRLLTGDDKFPAWLSKGERKLLETSIKDIEANAVVAQDGSGTHTTIAEAIASVSLVGGGGGRTVIHLKAGTYNENINIPTK... | 125 |
T1EG93 | 2.3.2.26 | ACT_SITE 1035; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MKLLNSAKSAREDRAIERNKVLAATKIQSVARGFLARCTFNKVIRLDLDSILQIPVNTNDEYKPALRPALEFFHAVERFLMVFKEQKDMQRFEHICRYILNSMSAEVLNKNVYASVALSKESLIQWINQLKRLLLISLQYFNVLKCDRVKDMKMITAMLHFQITFTSCSTWKFLNNSKNGDQLKPGMEQLCKNCMGHITSNGLYSFLRTLLISGLCKSKPLLKPSMLTAIITIAIKPLMASEYSESLFVSFILEILSVPSLVHHIITMSAESLTLMMSQRIFSMTLTVLDERQNAKIIFHALEGNYALCLLANLIQLGNA... | 65 |
A0A1L8GZ06 | 3.2.1.35 | ACT_SITE 141; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR038193-1" | MHTGSKQMMTWLVISVLYIITAMNKAQQLKNARIPFLQNKPFLAVWNAPTEQCRQRYKVNLDLSVFDIVANPNETLIGTDVTIFYHTHLGHYPYFTDDGQPVNGGVPQNESLKKHLNKSEHDINRLIPNIDFKGLGVVDWENWRPQWDRNWGSKLIYRNKSIELVKNRHPKWSDEQLKKVAKEEFDYAAKKFMTKTIALAQEKRSQGLWGYYLFPDCYNYDYKENPHSYTGRCPSIEMIRNDLLEWLWKESNALYPSIYLDYILKSTPNALKFVHYRVKEAMRVASMARKGYNLPVFVYSRPFYSYTLDTLSEADLIHTI... | 166 |
P93680 | 3.2.1.14 | ACT_SITE 140; /note="Proton donor"; /evidence="ECO:0000255|PIRSR:PIRSR001060-1" | MVYCTASLPLLLLLLVGLLAGEAFAEQCGRQAGGALCPGGLCCSQFGWCGSTSDYCGPTCQSQCGGVTPSPGGGVASLISQSVFNQMLKHRNDAACQAKGFYTYNAFIAAANSFNGFASVGDTATRKREIAAFLAQTSHETTGGWATAPDGPYAWGYCFLKEQGNPPDYCVPTAQWPCAPGKKYYGRGPIQISYNYNYGPAGRAIGYDLINNPDAVATDPVISFKTALWFWMTPQSPKPSCHNVITGRWTPSAADRAAGRLPGYGVITNIINGGIECGKGFNDKVADRIGFYKRYCDLLGVSYGSNLDCYNQRSFGVSTN... | 158 |
A0A3B6EJY5 | 1.11.1.7 | ACT_SITE 72; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MALDVLLRLLILAAVASAMPVPGPTDPAAAGLAIGFYNKTCPKAEELVLEEMRDIVHEDRTLGPALLRLLFHDCFVRVRAALLLCRAVPRRVHGSSECVSLNLNWMRGLQGCDGSIMLKSRSKKGERDAMPMSYSLRGFDEVERIKAKLEDECPLTVSCADIIIMAARDAVYLSNGPRFPVETGRRDGKVSLCIDAENDLAPPHANIVDLKTYFSVKNLSWKDLVVLSGSHTIGRAQCAAFAPDRLYNNSGLGVQDPTLDKAYAPELRERCEPGNKEDETLVDMDPKSPYEFDLSYYRDVLSNKTLFVSDQALLDDRWTR... | 14 |
F6HYN0 | 4.1.1.50 | ACT_SITE 81; /note="Schiff-base intermediate with substrate; via pyruvic acid"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 95; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 250; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRS... | MAVLYGTTNGDPPPPSPIGFEGFEKRLQITFSEAPIFIDPRGLGLRALTRSQLDLILDAACCTIVNHLSNSELDSYVLSESSLFVYPNKIILKTCGTTKLLLSIPPILQLAESLQLTVVSVKYSRGSFIFPNAQPAPHRSFSEEVAALNVFFGDLSPKAYVIGDPAIPNRNWHIYSASKEVRRSPLVREEVAVITVEMCMTGLDRDKASVFFKKSGEEDSAKEMTKLSGISDVMPTHVICDFEFDPCGYSMNGVEGGALSTVHVTPEEGFSYASYEAMGFDPGSVGMKTLMKRVLACFGPSQFSVAVTCPAGDDERWAME... | 196 |
Q5BEQ0 | 3.2.1.23 | ACT_SITE 196; /note="Proton donor"; /evidence="ECO:0000255"; ACT_SITE 308; /note="Nucleophile"; /evidence="ECO:0000255" | MATAFWLLLFLLGSLHVLTAAQNSSQSEWPIHDNGLSKVVQWDHYSFYINGQRIFLFSGEFHYWRIPVPALWRDILEKIKAIGFTGFAFYSSWAYHAPNNQTVDFSTGARDITPIYDLAKELGMYIIVRPGPYVNAEASAGGFPLWLTTGAYGSTRNDDPRYTAAWEPYFAEVSEITSKYQVTDGHYTLCYQIENEYGQQWIGDPRDRNPNQTAIAYMELLQASARENGITVPLTGNDPNMNTKSWGSDWSDAGGNLDTVGLDSYPSCWSCDVSVCTGTNGEYVPYKVLDYYDYFQEVQPTMPFFMPEFQGGSYNPWDGP... | 163 |
Q7T2V3 | 2.7.11.25 | ACT_SITE 242; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MDGLPKDEAFLWQSSKDNKENGVWSDVQSYGVSNPLWMAVFDYEPTAEEELTLRRGDLVEILSKDSTVSGDEGWWTGKIKDKVGIFPSNYVVSDDKYTTLTGAPKQCPLPLEIEFDELNLDEIIGVGGFGKVYKGLWRDEEVAVKAVRHDPDEDINVTAENVRQEAKIFCMLCHPNIIALTGVCLKPPHLCLVMEYARGGPLHRALAGKKVPAHVLVNWAVQIAKGMTYLHNEAIVPIIHRDLGSSNILILEKAENDDLFNKTLNITDFGLAREWQKTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGE... | 105 |
P33570 | 2.2.1.1 | ACT_SITE 410; /note="Proton donor"; /evidence="ECO:0000250" | MSRKDLANAIRALSMDAVQKANSGHPGAPMGMADIAEVLWNDFLKHNPTDPTWYDRDRFILSNGHASMLLYSLLHLTGYDLPLEELKNFRQLHSKTPGHPEIGYTPGVETTTGPLGQGLANAVGLAIAERTLAAQFNQPDHEIVDHFTYVFMGDGCLMEGISHEVCSLAGTLGLGKLIGFYDHNGISIDGETEGWFTDDTAKRFEAYHWHVIHEIDGHDPQAVKEAILEAQSVKDKPSLIICRTVIGFGSPNKAGKEEAHGAPLGEEEVALARQKLGWHHPPFEIPKEIYHAWDAREKGEKAQQSWNEKFAAYKKAHPQL... | 51 |
M3WG61 | 2.7.11.13 | ACT_SITE 559; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000550-1" | MRSGRRRSGPPLPPRVGSASARRRAVSERGASERANGSGSRARSGPTLPRPPPRRDLGRRPAFPPPRPRPGSPAPAPRPSPAAAAPRRRQEVVGGTMADVFPANDSTASQDVANRFARKGALRQKNVHEVKNHKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVTDEKLHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWN... | 100 |
A0A3B6FS14 | 1.11.1.7 | ACT_SITE 93; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MTMGSSRGIRFRSLVLLLVAYLGGMRAREAPLPLPSARSAGVNNRRAPERHGLSLDFYGKTCPAVDHIVANVTAERFRDHPATGPAVLRLFHHDCFVEGCDASILIAPAGKAAGEKVERDMEENRNLPQYGFDTVEMAKAAVESKCPGVVSCADILALAARDAVQLAGGPYYEVKKGRKDSKVSLAGKVRGSLPHANSTVDELLRVFAAKGLGAGDLVALSGAHTIGFAHCAHFLGRLYDFRGTRRADPFMDARLVKALRMTCPYTGGSARAVVPFDVSTPFQFDHAYYANLQARLGVLGSDQALFLDARTRPLVQELGA... | 14 |
A0A022PRR0 | 1.11.1.7 | ACT_SITE 73; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MASSISLLLLLSSSLLLHSYFQYAEAQQVADGLSWSFYNSSCPNLESIVRKQLKKVFKNDIGQAAGLLRLHFHDCFVQGCDGSVLLDGSASGPSEQTAPPNLSLRAEAFKIIDDLRRRVHKKCGGIVSCADILALASRDSIFLSGGPDYNVPLGRRDGLDFATIAATLANLPAPSSNTTTLLESLGTKGFTATDVVALSGGHTIGIGHCSSFTGRLYPNQDPVMDKTFARNLKTICPAPNSNNTTQLDLRSPNIFDNKYYVDLMNRQGLFTSDQDLYQDSRTRAIVTSFAANQTIFFENFVTAVVKMSQLNVLTGAQGEI... | 14 |
O66940 | 4.1.1.17 | ACT_SITE 342; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50" | MTKVVNYGEVQYGFAKRYFEEFLSERKGRIEKLLKPEKTPVLLMDIQGVKKKYLEVKYHFPEFNVYYAVKANDDESVIRALVEVGAGFEVASSQELEKVLRLGGKIEKVISSNPVKPPEFIEFAYQKGVRTFAVDSITEVKKIKDIAPRSKVYVRIAVPNEGSDWPLSRKFGVSVEEAVEILEYANDLGLVPYGITFHVGSQCNNLRNWFIAVKLSAQLWEKARAKGLKLQMLNMGGGIPVRYNYEALSVEDIAYYVKGLMRKYFPVQPYELQIEPGRGIVGDQGIMVTKVIGKAKRGSENWLYIDTGVFNGLAEALGGI... | 195 |
A0A804JLB1 | 3.1.1.11 | ACT_SITE 266; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MFRFQSVAFIIILLVLVDSGQVHCHTKGLRPGRRAPPPVNSTSAGMVEQQFMRWVRLVGGLRHSVFGRALNKAFPSYTLTVDKNPSVGDFTTIQEAVDSLPLINLVRVVIKVNAGTYTEKVNVSPMRAFITIQGAGADKTVVQWGDTAETLGPKKQPIGTFNSATFAVNAPYFIARNITFKVCVSCSIRMEFVWRPDPVLLLALLGFQNTTPVPPPGAMGKQAVSLRISGDTAAFVGCKFLGAQDTLYDHVGRHYYKDCYIEGSVDFIFGNALSLYEGCHVHAIAQNYGALTAQNRMSLLEDTGFSFVNCKVTGSGALYL... | 125 |
Q9VW24 | 2.7.11.25 | ACT_SITE 272; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038165-50" | MQPFSDSLSKSRDDLVTAASRQQQQLHGRRRHHGSSPNLSLDQTDNLRRSMACLQDEFGHLGIAATDLPFKSSDLDSPPRLQHHNNYAEITDSSAENTCQQRWPPHVGGAGAAFGHPDKPIGWMYGLLGCMKPVLSFIGKTGVIEVKSQRSEDWQIPFESITELEWLGSGAQGAVFSGRLKNETVAVKKVKELKETDIKHLRKLDHENIIKFKGVCTQSPVFCIIMEFCPYGPLQNILKEEQVMLPSRLVSWSKQIALGMQYLHSHKIIHRDLKSPNILISTNEVVKISDFGTSREWNEISTKMSFAGTVAWMAPEVIRN... | 105 |
Q11186 | 3.1.1.3 | ACT_SITE 48; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"; ACT_SITE 167; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01161" | MTMINSRPELMNLSFSGCGFLCVYHAGVAAAIKEYAPELLQNKILGASAGSIVACGLITGVCISHATSTILKVVSQARSRTFGPLHPEFNLLGIVRDELEVILPPNAYEMCTGRLVISLTRWSDHENVIIDEYRSNADLIDAIMCSCFIPLYCGITPPKFRGVQYIDGGVSDNQPIYDEHTVTVSPFSGESDICPPDWDSGSMLGVDFNGTSIRFTTRNMFRLMACLWPRSTDDLSRMCLQGFGDALRFLTKCGLAPCIRCLTIQTIDANEPAGRVSSECFSENDDAKKVTHVAVPRMKKRASANALNSFRTRGESECET... | 128 |
Q5B9F2 | 3.2.1.21 | ACT_SITE 253; /evidence="ECO:0000250" | MRSLIRSGALNAFLAASLATGQVLTWDEAYTKATSDLSLLSQEEKVGIVTGVTWQGGPCVGNTYEPTSIPYPSLCLQDGPLSVRFANPVTVFPAGINAGATWDRELIRARGVAMGAESRGLGVHVQLGPVAGALGKIPSAGRNWEGFSNDPYLAGIAMAEAIQGMQSSGVQACAKHYLLNEQEYNRDTISSNADDRTIHELYLWPFYDAVKANVASVMCSYNKINGTWACEHDALLNGLLKGELGFKGHVLSDWNAQHSTVQSANTGLDMTMPGSDFSTPPGSIYWGDNLAAAIADGSVPQERLDDMVTRILAAWYLVGQ... | 161 |
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