Entry stringlengths 6 10 | EC_number stringclasses 260
values | Active_site stringlengths 0 544 | Sequence stringlengths 20 2.05k | labels int16 1 260 |
|---|---|---|---|---|
Q8IIP4 | 3.4.19.12 | ACT_SITE 28; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 176; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 191; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331" | MCYYETHRIPTEKGYVNVYFEKQRRLYCLVHTTNNILQAHVYTFNDFKECEYKIDSLNILENEGNENHHQTNNNHSDSTNNEEKNNIESSNTNIFSYIKRGMYSFGNFNISVLYFLMNKHNMELQWVDNKEICQKLKDHKNSAILFNDEQLNDKTLIAFIINIVKLKFFDIYHHRHFYTIRKISDSWFKLDSSLNKPILLPTNKDVNNHLINIVKNNKIQKSDNYIIQVFQKVKDN | 175 |
E3KB60 | 3.1.1.11 | ACT_SITE 188; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MFIHSQIRNNLLAVALFSFFTWAQNSVPPSGALIVRQGKAGKGEYATISAAVAALKGLTGPKTIFVYPGTYSEQVKLVYDSPLILQGYTTDPTSATSNQVNVQVAVSAAQAGSNSKSATIWAYSDDIRISNFNVINSFGTGTDTQALALASTGKRQAFKYCTFSSFQDTVEVEGLSYFYGCRVEGAVDFIFGPGSAWFTNSILAVKAASKPVVTAQRNRAGGKTSIVIDNSQFISAGAKAGSTYLGRPWSEYASVVVQSCSLSDIINPAGWSAWSPPSDPRTSHVSFQEYKNSGPGANSKARQIGTQRSSKVEIAEVLGS... | 125 |
Q88YH3 | 4.2.1.11 | ACT_SITE 205; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00318"; ACT_SITE 342; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00318" | MSIITDIYAREVLDSRGNPTVEVELYTESGAFGRGIVPSGASTGEHEAVELRDGDKSRFMGKGVTKAVDNVNKLIAKEIVGYDVTDQRAIDQAMIKLDGTPNKAKLGANAILGVSIAAARAAADELEMPLYNYLGGFNAHVLPTPMMNVINGGAHANNDVDFQEFMIMPVGASSVKEAIRMGSETFHNLKAILNERGYSTAVGDEGGFAPDLKNNEEPFEILVEAIERAGYKPGKDIAIAFDCAASEFYNEETGKYDLKGEGENGQSFTAEEFVDLLDSIVDKYPIVSIEDPLDENNWEDWQMATAKLGKKVQIVGDDLF... | 200 |
A0A8M9Q7Y5 | 2.7.10.1 | ACT_SITE 832; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000619-1" | MWPVRFLLLFCLVFTFAVLQRSSGQSVCPGTDNKLSTLSDLDQQYKTLRKFYENCEVVMGNLEITSIERNRNLSFLKSIREVTGYVLVALNQFDYLPLENLRIIRGTKLYEGRYSLAIFLNYRRDGYFGLRQLGLRNLTEILNGGVYVDQNKFLCHADTIHWQDIIKNPRSELLVVPSNNSGNTCRRCHRSCNGRCWGPQEDQCQSLTKTVCAEQCDGRCFGPYVSNCCHRECAGGCFGPKDTDCFACTNFNDSGACVTQCPQPFVYNPTTFQLEHNPNAKYTYGAFCVKKCPHNFVVDHSSCVRACPSNKTEVEENNIK... | 97 |
B3SC96 | 3.1.4.11 | ACT_SITE 365; /evidence="ECO:0000256|PIRSR:PIRSR000956-1"; ACT_SITE 412; /evidence="ECO:0000256|PIRSR:PIRSR000956-1" | MAIEIDQTGSISEIWSKSDLQRWDNAVAHVCTLKVNTKGNVLYWRGQDTKYSGNKHRGTLIYPVWPFLNYNDQSNGRLHQVLTDAQYLKYLSSIVKYTARSDGDSDCLEINIIKDVRTGRAARLPKDSKLRNSLDMGGNNEESLEDKSVTVVYGYNMVDIFFITFVSNSAKVAKDWTTNLFALCHNLLALNAPPISVLEVQYNKLVCKTVGEGKISVKDFAKIYCNHKDDKKRVTDALAAVGLPSNIKTIVDVVTLILKYYKFHCSGAKKKPYLTLQQFVDFLNKDQRDPRLNEIIYPYVDEKRGQEIISKFETKKEFYS... | 153 |
A0A3B6D874 | 1.11.1.7 | ACT_SITE 161; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MANLAVAILFASLGAVATAQKASAPAAEMPAYQGSYPSYASPPVAEMPAYQGSYPSYASPPVPEMPAYQGSYPGHISSPAASPSYTFPAATPAPSQPSMAAPTASPPSPTPSPSPGRRRRLRVGFYRRSCPRAQKIVREAVRNATSKNPGLGAGIIRMHFHDCFVQGCDASVLLDPTAANPQPEKLSPPNFPSLRGFEVIDAAKEALEKVCPGRVSCADIIAFAARDASFFLSRARINFRMPAGRLDGRVSLSSEALDFLPPPFFNLSQLVDNFKAKNLDEDDLVVLSGAHTIGVSHCSSFTDRLPPNPSDMNPAFATLL... | 14 |
Q7XV05 | 2.7.11.1 | ACT_SITE 433; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MAEARLLRRRRLCLAVPFVWVVAVAVSRVGANTEGDALYSLRQSLKDANNVLQSWDPTLVNPCTWFHVTCNPDNSVIRVDLGNAQLSGALVPQLGQLKNLQYLELYSNNISGTIPNELGNLTNLVSLDLYLNNFTGFIPETLGQLYKLRFLRLNNNSLSGSIPKSLTNITTLQVLDLSNNNLSGEVPSTGSFSLFTPISFANNKDLCGPGTTKPCPGAPPFSPPPPFNPPTPTVSQGDSKTGAIAGGVAAAAALLFAVPAIGFAWWRRRKPEEHFFDVPAEEDPEVHLGQLKRFSLRELQVATDNFSNKNILGRGGFGKV... | 99 |
A0A061DWN8 | 1.11.1.7 | ACT_SITE 73; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAESALGVASASASASSPLFSTLAETSPLDNLLPFNYYHQSCPKLEEIINKKVKEWVAKDYTLAASLLRLHFHDCAVTGCDASILLNHEGSERRAEASKTLRGFQVIDDIKAEVEKLCPATVSCADILTAATRDATVLLGGPYWMVHYGRKDSRISNAKDANMVPHGRESITTLIEFFQSRGLNVIDLVVLSGAHTIGRTACDSIQHRVHGLNGTGMPTPNPSIDDHYLDFLQRKCRSCAPDSESNYVDLDATTPTTFDAQFYANLQKKMGLLSTDQMLYSDSRTRPIVNTLIQDPSIFRNQFWVSMVKLGNIQVLSGQN... | 14 |
Q5AU92 | 3.2.1.22 | ACT_SITE 511; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q9ALJ4"; ACT_SITE 573; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:Q9ALJ4" | MFRSTATVAAATAMGLLTATGHGSLAIAQGTTGSNAVVVDGTNFALNGASMSYVFHANSTTGDLVSDHFGATISGAIPAPKEPAVNGWVGMPGRIRREFPDQGRGDFRIPAVRIRQTAGYTVSDLQYQGHEVVDGKPALPGLPATFGEAGDVTTLVVHLYDNYSAVAADLSYSVFPEFDAVVRSVNVTNKGKGNITIENLASLSVDFPLEDLDLVSLRGDWAREANRERRRVEYGIQGFGSSTGYSSHLHNPFFALVHPSTTESQGEAWGFNLVYTGSFSAQVEKGSQGLTRALIGFNPDQLSWNLGPGETLTSPECVSV... | 162 |
A0A2I3RMA9 | 2.7.10.1 | ACT_SITE 655; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000628-1" | MEARVSLKRRIELTVEYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQ... | 97 |
A0A0K9NSI0 | 3.5.4.5 | ACT_SITE 100; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR006334-1" | MRTPTDDMVENSNNHSKSTDKIIPRRFVISAPEAKAMAEQRNLTLPNLLPSLVPMAQSLSRAPISNYPVGAVGLGISGRIYLGANLEFPGLPLHHSVHAEQFVITVAVSVAASDSISEQITHIAVSSFPCGHCRQFLQELRSASDIQIFVTSSSSLSFIPLSTLLPHPFGPTDLLHRDALLLLEQKDNNIIIQEEEERDGTVICKKSERVQYETEVKKAAERAARRAHAPYSGCPTGFAMGDEKGRIFSGSYAESAAYNPSLGPIQAAMIGFVGGGGGEYGSIVTAALVETKGSLVSQESTARILLEKVAPMCTLHVYHC... | 187 |
A0A1U8PRL6 | 3.1.1.11 | ACT_SITE 156; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MDSTPNVVVAKDGSGKYDCITEALAEVPLNSCDRFVIHIKAGTYKEKIIVTKEMTNVMFIGDGPTETIITNDTNCIKDNVKTFDTATVGVDGAGFMAKGIGFDNSAGPDGHQAVAFRASCDKVVMLNCHFTGYQDTLYAHKEKQFYRDCLISGTVDFIFGNAASVFQNCQIIVRKPGENQHNMITAHGKKEEETNTAIVLQNCTILGAPDYLPVKDKNKTYLGRPWKQFATTIIMQCQIDDIITPEGYSPMEGTIGLDTGYFAEFQNRGPGANTEGRVTWKAIKKIDMDEAMKWTPRVFLKSDEWLAQTGVPFESDMVPR... | 125 |
P0A7E5 | 6.3.4.2 | ACT_SITE 379; /note="Nucleophile; for glutamine hydrolysis"; /evidence="ECO:0000305|PubMed:11336655, ECO:0000305|PubMed:15157079"; ACT_SITE 515; /evidence="ECO:0000305|PubMed:15157079"; ACT_SITE 517; /evidence="ECO:0000305|PubMed:15157079" | MTTNYIFVTGGVVSSLGKGIAAASLAAILEARGLNVTIMKLDPYINVDPGTMSPIQHGEVFVTEDGAETDLDLGHYERFIRTKMSRRNNFTTGRIYSDVLRKERRGDYLGATVQVIPHITNAIKERVLEGGEGHDVVLVEIGGTVGDIESLPFLEAIRQMAVEIGREHTLFMHLTLVPYMAASGEVKTKPTQHSVKELLSIGIQPDILICRSDRAVPANERAKIALFCNVPEKAVISLKDVDSIYKIPGLLKSQGLDDYICKRFSLNCPEANLSEWEQVIFEEANPVSEVTIGMVGKYIELPDAYKSVIEALKHGGLKNR... | 252 |
E9G9V3 | 2.7.11.1 | ACT_SITE 155; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038172-1" | MAHGSPNVNCSLDEIDLNALKDPAGIFELIEVVGNGTYGQVYKGRHTKTGQLAAIKVMDVTEDEEEEIKLEINVLKKFSHHRNIATYFGAFIKKSPPGKDDQLWLVMEYCGAGSVTDLVKSTKGQSLKEEWIAYICREILRGLAHLHANKVIHRDIKGQNVLLTDNAEVKLVDFGVSAQLDRTIGRRNTFIGTPYWMAPEVIACEHNSEATYDNRSDLWSLGITALEMAESQPPLCDMHPMRALFLIPRNPPPRLKSKKWAKKFQNFIETVLVKDYHQRPYTEHLLKHPFIRDQPTERQVRIQLKDHIDRCKKHKQQKER... | 99 |
Q81GN6 | 1.11.1.6 | ACT_SITE 55; /evidence="ECO:0000256|PIRSR:PIRSR038928-1"; ACT_SITE 128; /evidence="ECO:0000256|PIRSR:PIRSR038928-1" | MNPNNRLTTNQGAPVGDNQNSRTAGRRGPVLLEDYHLVEKLAHFDRERIPERVVHARGAGAHGVFVTKNSMKQYTKAAFLQNEGTETPVFVRFSTVIHGQGSPETARDPRGFAVKFYTEEGNYDIVGNHLPVFFIRDAIKFPDMVHSLKPAPDTNIQTPDRYWDFMTLSPESTHMMTWVFSDYGTPASYREMEGFGVHSFKWINEEGKIVYIKYHWKPQQGVRNLNAKEVQEVQGKDFNHATRDLFDAIEKGNHPKWDLHVQVMQLDEMDSLDFDPLDPTKVWPEDRFPLIEVGTMTLNRNPKNFFAEVEQVAFSPSATV... | 13 |
A0A3B3ICK2 | 5.3.1.8 | ACT_SITE 293; /evidence="ECO:0000256|PIRSR:PIRSR001480-1" | MEEVRVFPLTCAVQNYAWGKAGLDSEVAKLVVGGDPLAVIDEKPYAELWMGAHPKGDAQIKDNRITQTTLGQWIAHYPACLGSKVKDAFQGQLPFLFKVLSVNTALSIQAHPNKDLAARLHAQFPEHYPDTNHKPEMAIALTRFQGLCGFRPVEEILAFLQRVPEFHALVGNEAAEELQHAVGDGARTSQALKKCFTRMMSCEKKVFVDELNELVKRVTEEGAAGKDTSGSNGDLLLRLHSQYPGDIGCFSIYFLNYVVLEPGQAMFLGANEPHAYLYGDCIECMACSDNTVRAGLTRKYIDDPSDPCVTLYDPPVPDFT... | 214 |
B8BQC2 | 1.1.1.37 | ACT_SITE 218; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000102-1" | MIVNRLATKALTALRSTSSATLKSCFSTSTPTSAKVAVLGAAGGIGQPLSLLCKLSPEVSTLSCYDIVGTPGVAADLSHIPTKSGTMGRLPSPVQWPMAGNGGLEETLTGADVVVIPAGVPRKPGMTRDDLFNTNASIVKTLVEGCAQFCPDAVIAIISNPVNSTVPIAAEVLKKHGVYNPKKLAGVTTLDVCRANTFVANSQGLDPKDVNVTVIGGHAGITILPLFSRVEGAKFTDEELEAITVRTQFGGDEVVAAKAGAGSATLSMAYAGYVFTENVLKALRGEEIVQCAFVESGLTDAKYFASPVKFGKGGVEEILP... | 5 |
A0A059D5X3 | 2.3.1.181 | ACT_SITE 178; /note="Acyl-thioester intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR016262-1" | MKSARIIEVCRMGIVNYLDALKLQERLIAARKSHKIPDTLLSLQHPPTYTLGKRRTDHNLLVPESDLGKMGAKLYYTQRGGDVTFHGPHQAILYPIISLRDIGLGARKYVEKLELTMIELASLYGVRACPGKSGETGVWVSDRKIGAIGVRISNGITSHGLAFNINPDLNYFKHIVPCGIEDKDVTSLKRETDMVLPTEEAIEDQLISCFVTQFGYTSIIWKDGESLLCGDEGDTR | 55 |
A0A7M7PP31 | 2.1.1.37 | ACT_SITE 1224; /evidence="ECO:0000256|PIRSR:PIRSR037404-1, ECO:0000256|PROSITE-ProRule:PRU01016" | MPSKTLCDRVIPTNVRNRVQELEGDLNDGLITEKGYIKKKSKMLFEHMSSDMQTTLKGLEDELKDEELTEKGYVNKVKSILAKFLDTCTPISNGDIQQENSSKKKLNKDTQSTVKNGSSSISSNGSGDPCKANGHSNGSHVRASDQEGNGSSQSEERMETDTPTSGKGDSKKKKKKGSPGGSEGGKGSKRKVLGDSDREEEEKKGREENKEVEEEEKEEESAGKTTPDANTPRSSKRKRSPKVDAKQPSIMSMFTKKPAKKEEEKVEESLSSVDENETKMENGDDGKKEEEEEEPSGPGGKRIKKEEEEEEKANDEPMSP... | 47 |
A0A5F8GYW1 | 3.1.1.4 | ACT_SITE 65; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 114; /evidence="ECO:0000256|PIRSR:PIRSR601211-1" | MKFVSILAVLFLPTLTHSNFWQFGRMIKLMTGKSAFFSYYGYGCYCGLGGRGNAVDDTDRCCKDHDCCYAELKTCCGCQPMFSTYHFHVVNGSVICYGGRNSGSRCGSMACECDKRSVHCFKENLPTYKKNYQFYSYSRCGVHKAPC | 130 |
Q2FW03 | 5.6.2.1 | ACT_SITE 305; /note="O-(5'-phospho-DNA)-tyrosine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01383" | MKSLILAEKPSVARDIADALQINQKRNGYFENNQYIVTWALGHLVTNATPEQYDKNLKEWRLEDLPIIPKYMKTVVIGKTSKQFKTVKALILDNKVKDIIIATDAGREGELVARLILDKVGNKKPIRRLWISSVTKKAIQQGFKNLKDGRQYNDLYYAALARSEADWIVGINATRALTTKYDAQLSLGRVQTPTIQLVNTRQQEINQFKPQQYFTLSLTVKGFDFQLESNQRYTNKETLEQMVNNLKNVDGKIKSVATKHKKSYPQSLYNLTDLQQDMYRRYKIGPKETLNTLQSLYERHKVVTYPRTDSNYLTTDMVDT... | 221 |
A0A3B3HC84 | 2.7.10.1 | ACT_SITE 792; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MEYHWILLFVFLQFTFPSGNTKPTIIPAKPQLVVELNQEFELQCWSDNKTHWRREERTKPLRASQINGKLTLAFQKADPASMGRYICVDEGTKEQASIYVFVKDPKNPFRKPLVPKILTREGDPASIPCLATDPNLSNLSLETCSRGPLAFGLQFTANLEQGILIHNTRKAYGGCYRCTGTLQRQTVESNEYELTVRPVPDEPPVVEMHQPTQVILTRNQTLSLTCNTTNVNGDITLRWIVPPGSGAVWYPQQPAKVDGTARIQLEKFTHTRSSTLHIAAVRPEDTGSYKCEARNEKGISTKSVWLDVYERGFISLTPSA... | 97 |
A0A8N7UQX6 | 2.7.11.25 | ACT_SITE 260; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000556-1" | MDAFSFPFNSSGPDSADGDGAAAEPQPGARLLGFGPAAAATPSGAGYWTAVFDYEATAEDELSLRKGDRVEVLSKDSLVSGDEGWWTGMIEDRVGIFPSNYVSSNGISEKIRDTPEDYCDYSVPPLHLLQIDFSELALEEMIGVGGFGKVYRAIWNGQEVAVKAARRDPDEDVSQTLESVRQEAKLFAMLTHPNIMALLGVCLQEPNLCLVMEYARGGPLNRALAGKRIPPHTLVDWAVQIARAMLYLHCQAIVPVIHRDLKSSNILILERVENDDLSNKTLKVTDFGLAREWHRTTKMSAAGTYAWMAPEVIRSSTFSK... | 105 |
A0A2K1YMZ5 | 4.1.1.50 | ACT_SITE 67; /note="Schiff-base intermediate with substrate; via pyruvic acid"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 81; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 239; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRS... | MAMSGFEGYEKRLELHFFGDDPAMLDNNLGLRLLDFESLEQVLNAVQCTVVSAVANQYFDAYVLSESSLFVYPTKIIIKTCGTTQLLKSIRPLIHYACNLGLSLCSCRYTRGTFIFPKAQPSPHTSFKEEVICLEDALPNNLCYRKASVMPSKTTTNSWHVFTASDESHIIPNDHDIYTVEVCMTDLDRVLARKFFLPPGGGNKSGDVAGKEMTKITGIGDINPRAMICDFAFDPCGYSMNGIHNDRYSTIHVTPEDGFSYASFECVGSIFDDDDIEHLVGTLRKAVQVFRPATLSVSTTCASHEVWPRVTHALEPLGLK... | 196 |
Q5JHZ2 | 1.8.4.11 | ACT_SITE 17; /evidence="ECO:0000256|HAMAP-Rule:MF_01401" | MGGIKIEPKTAIFAGGCFWCMEEAFERLPGVIEAISGYTGGWVENPTYELVSTGETGHREAVKVIYDPSKISYERLLDVFWRNIDPTDPGGQFADRGEQYKTAIFYLDEEQRELAEESKRRLELSGIFDEPIATEILPAKEFYPAEDYHQGYYFRFEANYKGYKLYSGRLGFIKSVWEKNRHFRLFPEREGYWLGYVKPSDAELKRQLTPLQYRVTQLGDTEEPFHNEYWNNHEEGIYVDVVSGEPLFSLLDKYDSGTGWPSFTKPLEEWAVVEAGECEGFLCGREVRSRFAGSHLGHVFDEPTPTGKRYCINSAALRFI... | 39 |
Q5N9Q7 | 3.1.1.29 | ACT_SITE 73; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:P0A7D1" | MRLLSGASASRIPCPLLSLARARARCLPVPASATACRAASSSAAAAAGDGGALKPWLFVGLGNPGKVYQGTRHNVGFEMIDVIAEAEGISLSSMQFKAMVGKGRIGDAPIMLAKPQTFMNASGESVGQLVSYFKIPLNQVLVMYDDLDLPFAKLRLLPKGGHGGHNGVRSIINHLKQNRDFPRLRIGIGRPPGKMDPANFVLRPFNRKEQEELDFAFHRGLEAVRIMALEGFNKSATYVNTAQSSEMLNR | 127 |
P9WIS7 | 2.3.1.12 | ACT_SITE 523; /evidence="ECO:0000250"; ACT_SITE 527; /evidence="ECO:0000250" | MAFSVQMPALGESVTEGTVTRWLKQEGDTVELDEPLVEVSTDKVDTEIPSPAAGVLTKIIAQEDDTVEVGGELAVIGDAKDAGEAAAPAPEKVPAAQPESKPAPEPPPVQPTSGAPAGGDAKPVLMPELGESVTEGTVIRWLKKIGDSVQVDEPLVEVSTDKVDTEIPSPVAGVLVSISADEDATVPVGGELARIGVAADIGAAPAPKPAPKPVPEPAPTPKAEPAPSPPAAQPAGAAEGAPYVTPLVRKLASENNIDLAGVTGTGVGGRIRKQDVLAAAEQKKRAKAPAPAAQAAAAPAPKAPPAPAPALAHLRGTTQK... | 54 |
A0A1D6I082 | 3.1.1.11 | ACT_SITE 248; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MRRHFRTRSTGRAGAKAPLLLWATSAVCSALLGILLASRSSFYFQQPASSPCTSSGSGEEAEAEVGRHHHRRRACDDQARWVAKMASLHNASLVLTVDRTGCANFTSLQKAVDAVPDYAAARTLIAVDAGVYAEKVVVWSNKTGVTLQGRGNLNTTIVWNDTANSTGGTFYSATVAVLAANFVAYNVSVQNTARPADPGDAGGQAVALRVRGDQAAFYWCGFYSSQDTLLDEQGRHFFRGCYVEGSIDFIFGNARSLYLGCTISSVANAAANGTVTGSVTAHGRASLAERTGLAFVDCNVVGTGQVWLGRAWGPYATVVF... | 125 |
O48773 | 5.3.4.1 | ACT_SITE 60; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 63; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 192; /note="Nucleophile"; /evidence="ECO:0000250"; ACT_SITE 195; /note="Nucleophile"; /evidence="ECO:0000250" | MYKSPLTLLTLLTICFGFFDLSSALYGSSSPVVQLTASNFKSKVLNSNGVVLVEFFAPWCGHCKALTPTWEKVANILKGVATVAAIDADAHQSAAQDYGIKGFPTIKVFVPGKAPIDYQGARDAKSIANFAYKQIKGLLSDRLEGKSKPTGGGSKEKKSEPSASVELNASNFDDLVIESNELWIVEFFAPWCGHCKKLAPEWKRAAKNLQGKVKLGHVNCDVEQSIMSRFKVQGFPTILVFGPDKSSPYPYEGARSASAIESFASELVESSAGPVEVTELTGPDVMEKKCGSAAICFISFLPDILDSKAEGRNKYLEMLL... | 215 |
A0A059DDZ2 | 2.7.1.21 | ACT_SITE 111; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR035805-1" | MASVRPSAAVPGPAPVPVPAPGRADGEIHVIVGPMFAGKTTALLRRVKSELTGGRNVAIIKSSKDTRYATDSVVTHDGMKFPCWVLSDLSSFRQEFGDDAYEKLDVIAIDEAQFFEDLYDFCSTIADRDGKIVIVAGLDGDYLRRSFGSVLDVIPLADTVTKLTARCELCGGKAFFTLRKTQETRTELIGGADIYMPVCRQHYVNGQTDADAAEILMKSGIRTDFFLEAASEV | 88 |
M5VQE4 | 3.2.1.14 | ACT_SITE 141; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001060-1" | MKLQSLIILSLALLLGISAEQCGRQAGNAVCPNGLCCSQHGWCGTTADYCATGCQSQCTSTATPTPNPSGGGGGDVSSVVSSAVFDQMLKYRNDARCKSNGFYKYDAFVAAARTFNGFGTTGDVNVRKKELAAFLAQTSHETTGGWATAPDGPYAWGYCFINENNQDVYCTPSAQYPCAAGKKYYGRGPIQLTHNYNYGPAGNAIGKDLIANPDLVATDPVVSFRTAMWFWMTPQGNKPSSHDVITGRWSPSAADKSAGRVPGYGVITNIINGGLECGRGQDARVADRIGFYKRYSEILGVSPGDNLDCYNQRPFA | 158 |
Q9LY50 | 2.7.11.1 | ACT_SITE 631; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MKRFINSTVTFSVTVTIAVIIFFLLSPVTSLGSGSTYAVVYGSDTVCALISGQPTQRILCYDTRLNINVTLNPGVSFSSIAAGDNFLCGIRSGGYSLLCWDNIGSYSPNRKRIYQNDNVLLETLSVGDKQICATVNGTNSLKCWRGSVSDQSKPPNERFRSISSGVGFSCGVSIRNNRILCWGTDPVKSNQIQTGFGNTPMVTISAGKSHACGLNTTGNLICIGNNDSGQLNVIAPDQPNLYSSSLSLGSNFTCAMRISNNSVVCWGGGAERFNNVTDSISFESISSGPGLICGLISSNLSIMCWNPTNFSRIFLPFPEV... | 99 |
Q9JZ53 | 4.2.1.11 | ACT_SITE 205; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00318"; ACT_SITE 337; /note="Proton acceptor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00318" | MSAIVDIFAREILDSRGNPTVECDVLLESGVMGRAAVPSGASTGQKEALELRDGDKSRYSGKGVLKAVEHVNNQIAQALIGIDANEQSYIDQIMIELDGTENKGNLGANATLAVSMAVARAAAEDSGLPLYRYLGGAGPMSLPVPMMNVINGGEHANNSLNIQEFMIMPVGAKSFREALRCGAEIFHALKKLCDSKGFPTTVGDEGGFAPNLNSHKEALQLMVEATEAAGYKAGEDVLFALDCASSEFYKDGKYHLEAEGRSYTNAEFAEYLEGLVNEFPIISIEDGMDENDWEGWKLLTEKLGGRVQLVGDDLFVTNPK... | 200 |
B3RVX8 | 2.3.2.26 | ACT_SITE 549; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MLIPNFISVCALNLLCIITVERWEERTDPYGRHYYVDHNTRTTTWERPEPLPSGWERRHDQYNRPYYVDHNTRTTTWHRPTSESIRTFQQWQERRQQNQDVRRQNYQQRYLIPSSGIQVVGRDLPPGWERRIDHNGRVYFVDHNTKTTQWEDPRTLAPLPPSWEKKVTDQGIVYFIDHSTKTTTYTDPRTGAPRYLKCFSSYQGNFDWRLAGFRQMCQDSALPGHTKIAISRNTIFEDSYNAIISLKPYDLRKRLYIMFKGEDGLDYGGLAREWFFQLSHEMLNPMYCLFEYANQNNYSLQINAASSVNPDHLKYFKFVG... | 65 |
D7SIE1 | 5.1.3.3 | ACT_SITE 188; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1"; ACT_SITE 319; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR005096-1" | MAKIRELCCFLLLAFAIAKVSEASSEIGVYELKRGNFSVKLTNYGATVVSVILPDRNGKLDDVVLGFDSVEDYKNDTTYFGAIVGRVANRIKGAQFTLNGKKYKLVPNEGKNMLHGGPKGFSDVIWHVQSYDKNSHVTFVYHSFDGEEGFPGDLHVSVTYMFFQTNKLVIKMTGRPLNKATPVNLASHSYWNLGGHSSGDVFSHQVQLFADKITPVDDELIPTGKILPVEGTPYDFLNIHEIKTRFHELPSGYDINYVLNYVGNEHFHKAAVVYESKSGRKMELWTNQPGLQFYTSNMLGTVKGKGGVTYNNYDGICLET... | 211 |
E1BMG4 | 2.7.11.13 | ACT_SITE 483; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000551-50" | MSPFLRIGLSNFDCGSCQSCQGEAVNPYCAVLVKEYVESENGQMYIQKKPTMYPPWDSTFDAHINKGRVMQIIVKGKNVDLISETTVELYSLAERCRKNNGKTEIWLELKPQGRMLMNARYFLEMSDTKDMNEFETDSFFALHHRRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFVWGLNKQGYQCQQCNAAIHKKCIDKVIAKCTGSAINSRETMFHKERFKIDMPHRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEALAMIESTQQARCLRDSEHIFREGPVEIGL... | 100 |
O69719 | 3.5.4.33 | ACT_SITE 55; /note="Proton donor"; /evidence="ECO:0000256|HAMAP-Rule:MF_00972" | MTTDEDLIRAALAVAATAGPRDVPVGAVVVGADGTELARAVNAREALGDPTAHAEILAMRLAAGVLGDGWRLEGTTLAVTVEPCTMCAGALVLARVARLVFGAWEPKTGAVGSLWDVVRDRRLNHRPEVRGGVLARECAAPLEAFFARQRLG | 186 |
Q02863 | 3.4.19.12 | ACT_SITE 62; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093"; ACT_SITE 407; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093" | MSWIKNVTESPTSLIKKVSCGLIIAASLYAIAPSLSALVFGDSKQSIGKYTTVGLINRGNDCFITSSLQGLAGIPRFVEYLKRIRTVLLELETKLSNNAKGDNPTVDNTTRHSRLENSSNSLAPLHESLTSLILDLISVKDRKTSISPKIVINTLESIFKSKISSKQNDAHEFTLILLQTLQEERSKLIDYSKQICNLNIPKFPFEGETSKFLVCLKCKGLSEPSYKQTFIRELSVPQQTSENLSNILAHDETEIIDDYSCLICQIRAILNHEEYRNFKDCTPDEILMLDRLKNYATKAPINENLPFEVEQYVKRYSKGN... | 175 |
B8BTL3 | 3.1.3.3 | ACT_SITE 11; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1"; ACT_SITE 13; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR604469-1" | MLAKADAVCFDVDSTVIDEEGIDVLADTLGKGPEVSAWTAKAMDGNIKFEDALAARLEIIKPSKSDIASCLEKHPLRLTPGVDRLVEALQKRGTSVYLVSGGFRLMIEPVARTLGVNVSNIYANTILFDDKGDYTGFDSNEPTSADQGKPKALRAIKEKAGYNTMVMVGDGATDAQAKPPADAFIGFGGVVVREAVKEKACWFVRDFEVMIDIVNKYDKR | 147 |
I1H4G2 | 1.11.1.7 | ACT_SITE 67; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAAAWLAALAFALAPLLCASEGNGTGIAFGYYNATCPEAETIVFRETARILRASPDLAASLLRLHYHDCFVQGCDASVLLDTTDAANPTEKDGKPNESLRGFDAVARVKDKLETACPATVSCADLLALMARDAVLLSKGPRWAVALGRRDGRSSSAGNCGELPPLYGNMTVMVEVFAGKGMDAKDIAVLSGAHTLGKAHCSSFADRLYSGANATCVTDPALDGRYAARLRLRCPGNNGGNGGAAAEMDAGSCGTFDTSYYRHVASKRGLLQSDAALMEHPVTAAYVRRAATGRYDGHFFSDFAESMAKMGAVGVLTGDQG... | 14 |
P18009 | 2.3.2.27 | ACT_SITE 379; /note="Glycyl thioester intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01398" | MKPINNHSFFRSLCGLSCISRLSVEEQCTRDYHRIWDDWAREGTTTENRIQAVRLLKICLDTREPVLNLSLLKLRSLPPLPLHIRELNISNNELISLPENSPLLTELHVNGNNLNILPTLPSQLIKLNISFNRNLSCLPSLPPYLQSLSARFNSLETLPELPSTLTILRIEGNRLTVLPELPHRLQELFVSGNRLQELPEFPQSLKYLKVGENQLRRLSRLPQELLALDVSNNLLTSLPENIITLPICTNVNISGNPLSTHVLQSLQRLTSSPDYHGPQIYFSMSDGQQNTLHRPLADAVTAWFPENKQSDVSQIWHAFE... | 66 |
A0A0A0L301 | 1.11.1.7 | ACT_SITE 69; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAETASYINTCKSFLVFLALSFPATTLALSFGFYAATCPAAELMVRNTVRSASSVDPTVPGKLLRLLFHDCFVEGCDASVLVEGNGTERSDPANKSLGGFEVIDSAKRTLEIFCPGTVSCADIVVLAARDAVEFTGGPSVQVPTGRRDGKISAASNVRPNIADTSFSVNQMMNLFSSKGLSVDDLVILSGAHTIGTSHCSAFSDRFRRNPNGQLTLIDASLDGAYADELMRRCPAGASTAATVENDPATSSVFDNQYYRNILSHRGLLQSDSVLISDGRTRARVESFANDEIGFFENWAQSFLKLSSVGVKSGDEGEIRL... | 14 |
A0A5F8GQ53 | 4.2.1.11 | ACT_SITE 206; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001400-1"; ACT_SITE 339; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR001400-1" | MSILKIHAREIFDSRGNPTVEVDLHTHKGIFRASVPSGASTGIYEALELRDGDESCFLGKGKRRVFPITHLPSLLQKMNVVEQDHIDKFMIELDGTENKSKFGANAILGVSLAVCKAGAAERCIPLYRHIADLACKEDLILPVPAFNVINGGSHAGNKLAMQEFMILPIGAPSFKEAMRIGTEVYHNLKNVIKEKYGQIATSVGDEGGFAPNILENKEALDLLKEAISKAGYTDEVVIGMDIAASEFRRDGKYDLDFKSPDDPSRYVTAKDLMDMYKSFIKDYPVVSIEDPFDQDDWEPWTTFTADAGIQVVGDDLTVTN... | 200 |
Q9RTB7 | 2.4.1.18 | ACT_SITE 309; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00685"; ACT_SITE 360; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00685" | MTFPLPLDHEHLQKLVTADLVRPDHLLGAHPTTEHGVQGVRFAVWAPNAQHVSVVGDFNDWNGFDHPLQRLDFGFWGAFVPAAQPGQRYKFRVTGAGGQTVDKTDPYGTFFEVRPNNASIIWQQDFEWTDAGWLEQRARRGQALEDPISIYECHVGSWARRDDGWFLNYRDLAHRLGEYVTYMGYTHVELLGVMEHPFDGSWGYQVTGYYAPTSRLGSPEDFKYLVNHLHSLGIGVLLDWVPGHFPTDEFALAHFDGSPLYEYADPRKGYHYDWNTYIFDYGRNEVVMFLIGSALKWVQDYHVDGLRVDAVASMLYLDFS... | 73 |
H2L884 | 2.7.11.1 | ACT_SITE 163; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037993-1" | MLLSKLNSLAADMPAKIQLQVHQVKEKEPFEKLYQVGAVLGSGGFGTVYAGTRISDGVPVAVKHVARDRVSEWGELPSGARVPMEIVLLKKVGTGFRGVIKMLDWFERPDSFIIVMERPENVKDLFDFITERGALPEELARSFFRQVLEAVRHCHSCGVVHRDIKDENILIDLRTGEMKLIDFGSGALLKDTIYTDFDGTRVYSPPEWIKYHRYQGRSATVWSLGILLYDMVCGDIPFEHDEEITRGQVLFRRRISTECQHLIKWCLSLRPTDRPSFEDVINHSWMQSTASSGVSTAQTEKTTTEIRLHSISHEPSSFTP... | 99 |
Q5B681 | 3.2.1.21 | ACT_SITE 152; /evidence="ECO:0000250" | MHSNILPVLTSVATLLGLVQGQSQQPYRDWAKAYEAAETLVLPWTLEQQANISVRDGTAPGFVPFEPSDGVRSVQGSGKDYDNPAMRTSSNLDDRTLHELYLWPWIDGVANGLGSVMCVMNRVNGIIGCENDHIMNGILKNETGFRGFIVPDVTAPVDKAAGLLGGLGWNSGYSVSEIMAAVKNGSIPESVMTEHALRIVATQLNLLQPPEEYAFPVETADLNVRDPSSKDFIRRAGSESIVLLKNKNNTLPLRSPMSLGIFGKDAANLATGPTPQSDFSNFAGDTYDGHLITGGGSYSPAPYVVSPLDALTARAADGQG... | 161 |
D8SHV8 | 3.2.1.52 | ACT_SITE 288; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1" | MLVAISILVFLPIALGGASSRIGFAEEKEVPVWPKPHSLLASGSGSLALAENFTLRSSPDSIATLSSAFARYREIIFLHHSIFLASRQIPESIPQLQALSVRISSPDETLQIGVDESYRLQIPDPDDATAALLTAETVYGALHGLETFSQICAFNFTTKMTEVRYIPVDIVDRPRFEYRGLLIDTSRHYEPLKIVRSVIDSMAYAKLNVLHWHIVDTQSFPLEIPSFPKLWNGAYTGAERYTLEDAKGIVEGVGYPELWPSGNCTQPLDVSNFAKTFPFKFMHLGGDEVDTTCWKKTRHIARWLAHNNFTAKQGYEYFVL... | 170 |
Q4WJV7 | 2.3.2.26 | ACT_SITE 1169; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MPSRSAYNQPLPPTLNSSTVYPNAALLSSSAERSAQRHIHHDVPILPTMTGNPATSPPHHRGHSRSISHPFPSSFGGRRRNPNPGFIDSDSDDDDIEVTHLPDVLSSSPRKGSSRPLPGGESTSTGKCMTCNSTVRWPRGLKVFRCTECLTVNDLEPYTSKDSGGQGISGKDGMTGLSIPRKAVPLSVERTRSIIDNCVSSYLRRLLDAPMPHGLTPGNRSEKPLVMGQDENRAHTHDHGSGLLSEPRVDARARSSSASSKPGKPNWFNGASNPLKPTASSLAPHADVRSPRLRSRNNSDVQVPPKDERLPRQVGMPSER... | 65 |
H3GNU1 | 3.4.25.1 | ACT_SITE 53; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR600243-1" | MSDFRRTQNTFGDAFPTSDQLHGGFSFDNCRRNELLLGQSGGKQKLKATKTGTTIVGVDGVVLGADTRSTGGSIVMDKNCEKIHYIAPNIYCCGAGTAADTENTTALISSQLELHRLNTDTQSRVVTAMTLLKRMLFQYQGHVSAALVLGGVDVTGPHLYSVYPHGSTDKLPFVTMGSGSLAAMSVFEFGYKDDMTEDEAKKLVQEAILAGIFNDLGSGSNVDLTTIKKVNGKVEVVKEINCIKPNEVSDLRSQINRDIVTHIPRGATRVLSSKTELFPANIVVEEATPMEL | 180 |
A0A452E9Y6 | 1.11.1.7 | ACT_SITE 226; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00298" | MLVCLHLQVFLASVALFEVAASDTIAQAASTTTISDAVSKVKTQVNKAFLDSRTRLKTALSSEAPTTRQLSEYFKHAKGRTRTAIRNGQVWEESLKRLRRDTTLTNVTDPSLDLTALSWEVGCGAPVPLVKCDENSPYRTITGDCNNRRSPALGAANRALARWLPAEYEDGLAVPFGWTQRKTRNGFRVPLAREVSNKIVGYLDEEGVLDQNRSLLFMQWGQIVDHDLDFAPETELGSSEHSKVQCEEYCIQGDNCFPIMFPKNDPKLKTQGKCMPFFRAGFVCPTPPYQSLARDQINAVTSFLDASLVYGSEPSLASRL... | 14 |
F7G4T3 | 3.2.1.35 | ACT_SITE 134; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR038193-1" | MCKLMRWLAMMMLCVLVDTQNFKPTKAPMFQNKPFIVFWNAPTSQCKNRHHVDLNLDTFGIAANSDEALNGDKVTIFYHNVFGYYPHISDSGESFHGGVPQNQSLSNHLSQVQKDINRVLPSKDFQGLAIIDWENWRPQWIRNWDNKVIYREHSINLVRSRHPSWPDSKVKTVAQKEFEKAGKNFMNSTLHLGLKMRSQGLWGYYLYPECYNYNYKNHPHKYTGKCPNIEISRNNQLLWLWKASTALFPSIYLPEILKSSTNVLKFVHHRVREAIRVATVARQDYVLPVFVYSRPFYSYSLIALSQMDLVHTIGESAALG... | 166 |
I1MRB4 | 4.1.1.50 | ACT_SITE 65; /note="Schiff-base intermediate with substrate; via pyruvic acid"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 79; /note="Proton donor; for catalytic activity"; /evidence="ECO:0000256|PIRSR:PIRSR001355-1"; ACT_SITE 245; /note="Proton acceptor; for processing activity"; /evidence="ECO:0000256|PIRS... | MAVSGFEGFEKRLELHFFGDDPAMFPLGLRKLEFDSIEQVLEAVQCTVVSAVGNSYFDAYVLSESSLFVYPTKIIIKTCGTTQLLKSILPLIHYADHHLGLTLSSCRYTRGSFIFPKAQPFPHTSFKDEVTYLQDTIPSSLCFRKASIMPSKSSSHSWHVFTANDNTHTHTHSPMPYDHDNELLFTMEICMTELDPILARKFFRRPDDEKSGDSAGKEMTELTGINEINPDALICDFAFDPCGYSMNGMDGDWYSTIHVTPEDGFSYASFECVGSVDNGNIGHVLMKVVQIFRPGTMSISTTCNGFSSNDVMWTEMASAV... | 196 |
P32732 | 5.4.99.25 | ACT_SITE 39; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_01080" | MVNGVLLLHKPVGMTSHDCVMKIRKLLKTKKVGHTGTLDPEVSGVLPICVGRATKIVEYLTEKSKTYDAEITLGFSTTTEDQTGETVETKPVNHDIDKADVEKVLNSLKGKQEQIPPMYSAVKVNGKKLYEYARAGIEVERPKRMITIEDIALTTEIKHHGETASFRFTVTCSKGTYVRTLAVMIGEKLGYPAHMSHLIRTASGDFSLDECFTFDELEAQAQSGTVEEHTVPIERALNHLPKWIISDTLAKKVENGALLETPEQFSEMTSGDRIAVFTESGTCLAIYFPHPAKKGLLKPAKVLMQKSEQ | 218 |
A0A9J7NAB6 | 3.4.19.9 | ACT_SITE 132; /note="Nucleophile"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 244; /evidence="ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 375; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR615527-1, ECO:0000256|PROSITE-ProRule:PRU00607"; ACT_SITE 487; /evidence="ECO:0000256|PROSITE-ProRule:... | MMANLAVLNLVIVAVGIAQGLSVRDFPEVNDRPIIGVIAQASGGAIAKFGKTYIPASYIKYLESAGARVVPIRVNLTTAEYTKLFNSLNGVLYPGGSVNLFTSGYAKSAKIFYDLAIKAFDEGDYFPVWGTCMGFQQLTALTSDRNVLTTCKGTENKSYKLNFSKDYMSSRMFGKVPVDILTDLATLPLTPNFHKYCLTPQIFTDDAKLKSFYKILSTNTDDDGMEFVSSMEAIKYPVYGVQWHPEKNNFEFGSILKITHSDAATRVSQAMANFLVSEGVIAQASGEARAKFGKTYIPATYIKYLESAGARVVPIRVNLT... | 176 |
P19172 | 3.2.1.14 | ACT_SITE 156; /note="Proton donor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01258" | MTNMTLRKHVIYFLFFISCSLSKPSDASRGGIAIYWGQNGNEGNLSATCATGRYAYVNVAFLVKFGNGQTPELNLAGHCNPAANTCTHFGSQVKDCQSRGIKVMLSLGGGIGNYSIGSREDAKVIADYLWNNFLGGKSSSRPLGDAVLDGIDFNIELGSPQHWDDLARTLSKFSHRGRKIYLTGAPQCPFPDRLMGSALNTKRFDYVWIQFYNNPPCSYSSGNTQNLFDSWNKWTTSIAAQKFFLGLPAAPEAAGSGYIPPDVLTSQILPTLKKSRKYGGVMLWSKFWDDKNGYSSSILASV | 158 |
A0A6I8N549 | 2.7.11.1 | ACT_SITE 142; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038172-1" | MDPRHCAALQISTRDPQEDFELLQRVGGGTYGEVFKVTGPSPILPALPPTPGCVSPTDDDVSTLQQEILIIRNCKHPNIVAYHGSYLRFNKLWICMEFCGAGSLQDIYHVTGPLSELQIAYVCREVLQGLAYLHSQGKIHRDIKVKATGAGPVLWEGADFGISAQISATFARRLSFIGTPYWMAPEVAAVALKGGYTELCDIWSVGITAIELAERQPPMFDVHPLRVLFLMTKSGYQPPKLKEKARWSAAFHNFVKVALTKNPKKRPCATKMLSHQMVAQPRLNRSLTLELLERLRDPGKHRAGPGGAEPEEEEPEVRGR... | 99 |
A0A9R0IJU3 | 1.11.1.7 | ACT_SITE 70; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MRLGSLSSMLPLGFVLMTFISHCYGHDLRVGFYDGKCGGQDIEKLIYGIVKKKIAKDPDVVSDLTRLLFHDCFVRGCDGSILLKGNHTEQKAHINKHVAGMDDIDDIKKAVEKVCPGVVSCTDVLVMAARDAGFLAGGKRYDVETGRRDGRVSSSKEAEASLPPPTIPVNKAIQMFAKNGLNEREFVVLLGGHTVGTAHCNSFKNRLYNFNNTQKPDPTINSALLPLLCKTCPLHSQSENETFLDHNPTSHFKMDNDYYKQIVAHNGTLEIDQNLAINPLTRGIVEELANSPDQFLNEFGPAMVKMARIGVLTGDRGEIR... | 14 |
Q6CG20 | 2.3.1.225 | ACT_SITE 187; /note="S-palmitoyl cysteine intermediate"; /evidence="ECO:0000250" | MWLKIYLLSILAISVFTFVFLFGALPQFEDTAVWKFRKWLSNRPAAIRSWDSKYCGGRLSVVGDFCGSVVAPAAPWSVPILYCAFTTYMFSAYYEDLHPFIAENHWYYAWLAPVAYTILVVSFVLATFSDPGKITKQNHALLLNQFRFDNLMFLEDTECSTCKFTKPARSKHDRFTNKCVAKFDHYCLWINNTVGLYNYRWFLFFLLGNVWTLCWGALLAGLKMIVMVAAEYKDHPKPLPSIFSQWWQVMITNENKRVGIIFLLSVSTGALACAFTAMHFYYIYLGATTNETDKWGDIHAAISEGSVWMFQKPGFKLDRS... | 57 |
U5CVE0 | 1.11.1.7 | ACT_SITE 64; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MASDHVLIVLITFFLLLNLSSGALTVQFYRHSCPQTETIVRTIVTQHFTSDPSIPAGLLRLHFHDCFIRGCDASVLIDSRGGHAAEKEAPPNLTLRGFEIIDEIKSELEKQCKGIVSCADILALATRDGVALAGGNFYALPTGRRDGTISNIEDVHLPGPSFSVDAALTAFTSINMDLSDLTTLLGAHSIGFCHCGFFNERLYNFMGTGFPDSTMDFSVAQSLRSTCPQPLQQITNTSADPRIFMDQSTNSPFSLDNSFYHGVLSGRSVLQLDQELAYTDVTSTMALNFSRNKTLFLQRFSKAMIKLGNVGVLTGLQGEI... | 14 |
A4PES0 | 2.7.10.2 | ACT_SITE 341; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MGDNGDNKELKQKLNFSYSEEEQEDEGQKEAQESKKVQYHTPERCGHQDSEAKFTPPRTPLNHVCELSTPQVKDRASPDQGLRTPVSRPHTRPETPAPPDKSKPPPHCESPFTPRGHSSQSVISTGKLPSRGSKHLRLTPGPLTDEMTSLALVNINPFTPESYRRQFLKSNGKRKTRRDLEEAGPEEGKVEKGLPAKRCVLRETNMACRYEKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSTKPVSGLSDENLAMHEVYAHSVLGHHPHVVRYYSSWAEDDHMMIQNEYCNGGSLQAAISENAKSGNHFQEPKLKD... | 98 |
Q9F305 | 2.1.1.33 | ACT_SITE 168; /evidence="ECO:0000250" | MSDSHHTPEAASASLRHVRAKGEPRFPDGPKADPAGSHFERRIRSFQPRRSRVTAGQADALQRLWPLWGLDIDGRRVVDLAELFGNARPVVLEIGFGMGETTARMAAADPDTNILAADVHTPGQGNLLGLAERQELPNIRVANGDAIILLREMLAPGSLAGLRVYFPDPWPKKRHHKRRLIQPEFLTLAATRLAPGAVVHCATDWEPYAEQMLDVLTAHPDFENTVPGGGFAPRPEHRPLTRFEGQGLDKGHVVNDLLFRRVQHKEPPPNG | 45 |
D8QW81 | 2.7.1.11 | ACT_SITE 219; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03186" | MANGGTDVKQGPKILLEKVPHLKSFLPDLRSYPNPLYQNSYFHPVPGFFVTDREAIAQNIVMDVDKPVDQNQRYFARAGPRERVFFEGEEVKVAIVTCGGLCPGMNTVIRELVNGLWYQYHVRDIRGIQAGYRGFFSSEHVPLTPKVVDHWHKQGGTRLGTSRGGFDLQKIVNAIQDRGYNIVFLIGGDGTLRGAVEIFNEIKKRSLKVSIACIPKTVDNDVGIIDRSFGLQTAVEVAQEAISAAHVEAESTPNGVGLVKVMGRYAGHIAVNATLSSRDVDCCLIPEIKFFTQGRGGLFEFMEQRLMDNGHCVIVMAEGA... | 84 |
Q9UTG2 | 2.3.2.26 | ACT_SITE 639; /note="Glycyl thioester intermediate"; /evidence="ECO:0000305" | MENIRFEVQLTILHVEGLWKNGLLRSLKPYLLISVDDDQFIKTNVASGTLRLSWGFTQKLTVSPQSIILLQLFDEKQKNETSDGFVGLGAAVVNSFLPFNNPKDDYKTRITLRSPSGSYRGSVVCLFKRSKFLPEELPADKSQICTDIIDDASGCAWETRIDEFGHVYYLKSPQLSVISAISHEKLENLTPKQLKEVFSQFLFNNQSKSSLKINLEYKVIKHLLEHYPLALSVRQQVAVEKGPLPAGWEMRLSEDYHVYFVDHSTKTTTWSDPRDNVVASDSVSENTDSIQQINDEYQRKIAYMYDRPEMAVNDAQLQLK... | 65 |
Q9R063 | 1.11.1.24 | ACT_SITE 99; /note="Cysteine sulfenic acid (-SOH) intermediate"; /evidence="ECO:0000250|UniProtKB:P30044" | MVQLRFCVLGSIAGSVLRASATWTCVAGRAGRKGAGWECGGARSFSSAAVTMAPIKVGDTIPSVEVFEGEPGKKVNLAELFKDKKGVLFGVPGAFTPGCSKTHLPGFVEQAGALKAKGAQVVACLSVNDAFVTAEWGRAHQAEGKVQLLADPTGAFGKETDLLLDDSLVSLFGNRRLKRFSMVIDKGVVKALNVEPDGTGLTCSLAPNILSQL | 12 |
A0A5P8YFI9 | 5.3.1.8 | ACT_SITE 274; /evidence="ECO:0000256|PIRSR:PIRSR001480-1" | MLKMNNAVQNYAWGSTDALTQLYGIPNPQGMPMAELWMGAHPKSSSQVLDANGQWHSLRDVIDQDPDNTLGSDIFKRFGELPFLFKVLCAAQPLSIQVHPSKAAAEVGFAKENQAGIPLDAAERNYKDANHKPELVYALTPFQAMNGFRTLEDIQALLQPLAAAHPDIAAFLRQPDTEHLASLFASLLSMSGETKTRALGILKAALNSQLGEPWDTIRSISCFYPDDSGLFSPLLLNAVTLQPGEAMFLYAETPHAYLNGVALEVMANSDNVLRAGLTPKFIDIPELMSNLQFIPKPANALLTTPKQQGNELIFPIPVED... | 214 |
D6WF82 | 3.1.3.48 | ACT_SITE 223; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR000926-1" | MSSGNNIESEYSKLNSKNEWSAIFQKIRSESVKNSSPYTEALKPQNKNLNRYRDVSPYDHSRIVLKRGSTDYINANLIKVEKANRQYILTQGPLCNTVSHFWLMVWEQHSKAVLMLNKLVEKKQEKCYQYWPSKVGPDYIMTMEDVGLTLEYVEQQDHSYYLQRVLRLTDISTKESRDILQFHYTTWPDFGVPSSPTAFLEFLRKVRDAGVLEPTVGPAVVHCSAGIGRSGTFCLVDSCLVLMEKFGLNSVDVKEILCEMRSYRMGLIQTPEQLRFSYQAIIEGAKQLLNPDSSPTENHIIVDNEPEDGVASDSDDDGPP... | 149 |
A0A1D6KM34 | 3.4.19.12 | ACT_SITE 98; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1"; ACT_SITE 171; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR038120-1" | MSWAAIENDPGVFTELLQQMQLKGLQVSNQLSSLYESMFLLKVDELYSLDLDALNDLQPIYGLILLYKWRPPEKDEGPVIKDAIPNLFFANQIINKACATQAIVSVLLNSPGITLSDELKKLKEFAKDLPPELKGLAIVNCASIRMLNNSFARSEASEEQKPPSGDDDVYHFINYVPVDGVLYELDGLKEGPISLGKCPGGVGDAGWWLRLAQPVIKEHIDLFSQNEIRFSVMAILKNRKEMFTVEIKELQRKREGLLQQMGDPNASRHVEQSLAEVAAQIESVTEKIIMEEEKVKKWKAENLRRKHNYVPFLFNFLKIL... | 175 |
Q9X1R0 | 5.4.99.12 | ACT_SITE 52; /note="Nucleophile"; /evidence="ECO:0000255|HAMAP-Rule:MF_00171" | MKRVAAVIEYDGSNFFGYQGQPDVRTVQGVIEDALERIFKQRIYTQAAGRTDTGVHANGQLIAFNCPNDRMTTEDIRNAMNANLPDDVYVKEVFEVPVNFHPRFDVTKRIYHYFILTSRQKNVFLRKYVWWFPYELDLDAMRKAVKYLEGTHDFTSFKTGSDERDPVRTIYRIRILRLKNDLVLIRVEGRSFLRRMVRNIVAALVKVGLKQWEPEKMKEVLEARDRSAAAGTAPAHGLYFYKVLF | 217 |
B8GTF9 | 1.3.3.3 | ACT_SITE 109; /note="Proton donor"; /evidence="ECO:0000255|HAMAP-Rule:MF_00333" | MTEQVRIEPVIDYLTGLQDRICQGIAGADGSGEFKEDSWTREEGGGGRSRVLTEGAVFEQAGINFSHVTGASLPPSATAHRPELAGRRFQATGVSLVIHPRNPYVPTSHANVRFFIAEKEGAEPIWWFGGGFDLTPYYGEDEDCVHWHRVAKAACEPFGPEVYPRYKQWCDEYFFLRHRNEPRGVGGLFFDDLNEWGFEKSFAFMRSVGDHYLDAYLPIVARRKDTPYGERERDFQLYRRGRYVEFNLVYDRGTLFGLQSGGRTESILMSLPPLVRWRYNWQPEPGTPEARLYEHFLKPREWVE | 27 |
C5YIK0 | 3.1.1.11 | ACT_SITE 245; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MQMSAKINGAAAAAAFLLFYTHLYFPTTVHLYSSATPLLGALVNLTTPSLPLYPFSVDSTSTHHQYDCKYNPLCDDFPPDFPPPDIPAVSIFCVDPNGCCEFTTVQAAVDAVPNHSSKRNVVWINKGIYFEKVTVPASKPNITFQGQGFDLTAIAWNDTAKSANGTFYSASVSVFASGFIAKNISFINVAPIPRPGAVDAQAVAIRINGDQAAFWGCGFFGAQDTLHDDRGRHYFKECFIQGSIDFIFGDARSLYENCRLISIADPVPSGQRSITGSVTAHARVSEDDNTGYSFVNCSIGGTGWIWLGRAWRPYSRVIFA... | 125 |
A0A3B6AZ23 | 3.1.1.11 | ACT_SITE 303; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MPRAHPRRRRLLPVAAAAAALALLALLVLLPTAPPGGPAAPASLLRAAIAAHPSPASYAHPCADHLSLSLHRLRAALPALESGDLPAALHLASASLQCQYDCSHLLSLPAFPSHSLTSRFLNSLTPQTLTAYPKPASFYSTVAAFPARVRPAATVCKSNPACDFSNVQDAVNAAPNYTAGHFLITVSAGIYKENVVVPFEKTNVLLVGEGMGATVITASRSVGIEGLGTYDTTTVAVVGDGFRARDITFENTAGAGAHQAVAFRSDSDRSVLENVEFRGHQDTLYARTMRQLYRRCHITGTVDFVFGNAAAMFEECVIET... | 125 |
H3GMB3 | 2.3.2.26 | ACT_SITE 631; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MTAGLAVLVALAVLLFVGAIVMLLFFCRRIQVQRERESLVFIQETADVYREELNDSFMEQALWRCGVCKFLNHPEHKLCDLCQTLRGAERDVAGSKKHSRSSFTRSSLSASAAQRMGRIGETEAFSSSHADDAIGGSFGRPSFEFPRKKKKSKSKLSKLQLAASRRQQWKRMPTTDGLHRWVRQESTRKQSRAQRDSIESDPGGRLSLNRYLDATERDSNLSVGYIRVRDSLGQLVLNESDVVATDFHYRINILDGTGSSELIMNLEGVHNLPFPDKIRWFSTEIHRLWLPWESGHAELVVRRDHLLQDSFELVAAMKPY... | 65 |
Q60DX8 | 3.2.1.21 | ACT_SITE 207; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:Q7XSK0"; ACT_SITE 421; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q7XSK0" | MAVSSSTSTCSSFSLLLLLLLLAAAPWRSGEAAAAAARALNFTRQDFPGEFVFGAGTSAYQYEGATDEDGRSPSIWDTFTHAGKMPDKSTGDMGAGGYHKYKEDVKLMSDTSLEAYRFSISWSRLIPRGRGPVNPKGLEYYNSLIDELVERGIEIHVTLYHLDFPQILEDEYHGWLSPRVIDDFTAYADVCFREFGDRVRHWTTMDEPNVLSIAAYDSGAFPPCRCSPPFGANCTAGNSTVEPYVVAHNSILAHASVTRLYRDKYQATQEGFVGMNIYSFWNYPFSSSSADIAATQRALDFMVGWILDPLVYGDYPEIMK... | 161 |
Q9V4E5 | 2.7.10.1 | ACT_SITE 868; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000666-1" | MKMVGCHPNDKKVKYDGIKSKTSSVTILTSVLNDAISALKSAFYKNQAPISEQNRSQIVSRMSLLRTILLIIISIHFKLAHADQVVLLDTTREATLEWTRYPYGPQAQTPGWVEESFTDFVKGINWRSYVVCDVAYHNVNNWLWSPFIDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFSLLFYEFDAATREPPPWQTDSYRLIARIAAGEGRFNQNSDVDINTEVKSIAVNKKGVYFAFRDQGACISVLAVKVYYITCPAVTENFAHFNETPTGREITIIEKQNGTCVDNAEPYETPTYLCKGDGKWTILTGGCRCK... | 97 |
E0XKJ9 | 3.2.1.35 | ACT_SITE 129; /note="Proton donor"; /evidence="ECO:0000255|PIRSR:PIRSR038193-1" | MKLHQGLVCLSVLILLPTCILGDRKFEVYWNIPTFMCPDQNKTIMDLNKKHGVIQNTEDLFRGDKISLLYHPGAFPAITRNKTTNTLIYENGGVPQAGNLSLHLKLLEKDINEQITDKNFSGLAVIDFELWRPIFRQNGGSLSDYQNLSLKLEKDLHPEFNEDQLRKEAERRIEKFGRSFIKQTLIKAKKLRPKAQWGYYAFPYCFNGRRRYVDTCIPSAKIDNDRILYMFENSDVIYPAVYLQTDLAQKNQTGLVKGRVDEAVRMAKMVKKPAKPPVLVYHRYVFTDTLEYISKENTTAVFKAMKDNGADGVIIWGSSF... | 166 |
A0A804K6G9 | 2.3.2.26 | ACT_SITE 1859; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | METRSRKRAEASSSAPSSQPPAARRPSKRSRTNPPPPSTILTRSRRSRNSSPPLLPPPPSGPMDSSAGDSSGRRRGSGKNHHPPAERDRDRDASDKGKEREPEASRSRDRDRARDRDAGRILGLNFDGGGADDDNDSEGGASALHQNLTSTSSALQGLLRKLGAGLDDLLPSSALLASSSSQQSSRLKKILTGLRADGEEGRQVEALTQLCEMLSIGTEDSLGSFSVDSFVPVLVGLLNHESNPDIMLLAARALTHLCDVLPSSCSAVVHYGAVPCFCARLLTIEYMDLAEQSLQALKKISQEHPTACLRAGALMAVLSY... | 65 |
Q25BW5 | 3.2.1.21 | ACT_SITE 170; /note="Proton donor"; /evidence="ECO:0000269|PubMed:17376440"; ACT_SITE 365; /note="Nucleophile"; /evidence="ECO:0000269|PubMed:17376440" | MSAAKLPKSFVWGYATAAYQIEGSPDKDGREPSIWDTFCKAPGKIADGSSGDVATDSYNRWREDVQLLKSYGVKAYRFSLSWSRIIPKGGRSDPVNGAGIKHYRTLIEELVKEGITPFVTLYHWDLPQALDDRYGGWLNKEEAIQDFTNYAKLCFESFGDLVQNWITFNEPWVISVMGYGNGIFAPGHVSNTEPWIVSHHIILAHAHAVKLYRDEFKEKQGGQIGITLDSHWLIPYDDTDASKEATLRAMEFKLGRFANPIYKGEYPPRIKKILGDRLPEFTPEEIELVKGSSDFFGLNTYTTHLVQDGGSDELAGFVKT... | 161 |
P07334 | 2.7.11.1 | ACT_SITE 128; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MVKRHKNTIGVWRLGKTLGTGSTSCVRLAKHAKTGDLAAIKIIPIRYASIGMEILMMRLLRHPNILRLYDVWTDHQHMYLALEYVPDGELFHYIRKHGPLSEREAAHYLSQILDAVAHCHRFRFRHRDLKLENILIKVNEQQIKIADFGMATVEPNDSCLENYCGSLHYLAPEIVSHKPYRGAPADVWSCGVILYSLLSNKLPFGGQNTDVIYNKIRHGAYDLPSSISSAAQDLLHRMLDVNPSTRITIPEVFSHPFLMGCTSLSSMDSTTPPTPSLSIDEIDPLVVDCMCVLWKKSSSKKVVRRLQQRDDNDEKYVYKV... | 99 |
A0A2R6X4G4 | 2.3.2.26 | ACT_SITE 1205; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MVLSSLALSIRGLFRSIRLAALASRSRRTSSSSAMETRTMIDDERAGVQSPLILVPGVGVGVAVAEREREIGELREAVGFMMAARMASTQPIVSRTASSKRKLEELEIGIADLSGSANSQVRARREARDEDLEGSVAESSGRERYESGLCSSGEAQALDGESLMREEGGNEAIDADAMWEEEPGWNRTVLVIANCEITKVVAPEKGDADDVLEETVGVQATNEAGSSLTSILVPSQVDTGVYTGPSLGVAAVISGESLGPDAGIIGRGLVEEVASGKDSEAPRESEFDGLRSREKERDSMLFGHEEESSTRRYTHSLSTA... | 65 |
P47269 | 4.1.2.13 | ACT_SITE 84; /note="Proton donor"; /evidence="ECO:0000250" | MLVNFKLMLQKAKLGKYAIPHININNYEWAKAVLTAANQANSPIIVSVSEGALKYMSGYSVVIPLVKGLIESLSVKVPVTLHLDHGSYDACIQALQAGFSSVMFDGSHLPFEENFNKSKKLIEIAQKTNASVELEVGTIGGEEDGVIGQGELANVDECKQIASLKPDALAAGIGNIHGIYPKNWKGLNFPLIETISKITNLPLVLHGGSGILENDVKKAISLGICKLNINTECQLAFAHEIRKYIESNKDLDLNKKGYDPRKLLKEPTQAIVDTCLEKIDLCGSRNKA | 197 |
H3GE58 | 2.7.1.21 | ACT_SITE 79; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR035805-1" | MQLIIGPMFSGKSTELIRRIHRYQHAKLECLVVKYLFDTRHSEEMLSTHDKVFVEAMPVQTLAEVRPFLDEYDVIGIDEGQFYPDLVKFCQDAANMGKVVVVAALDATFERKAFDSVIELIPTAEQVIKLNAICSSCGQDAAFTRRLVADKTLELIGGIEMYEPRCRQCFNLD | 88 |
A7ED96 | 3.1.1.11 | ACT_SITE 198; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MYSLIPILSLAATLLGGVSAAPVLEARAAARTSAPSGAVVVDKTGATPGSYTTFQQGVNALSTTTTANQYLFIYPGVYTEQVYVPLLQSNLTIQGYTEDATTYAGNQVTLTYNLALLNTINDDMTATLRQWNTNTKVYNLIIQNTFGHVNSNGQNLAISAHTTNQGYYATQFIGYQDTILANTGTQLYAKCLVVGAIDFIFGQTAQAWFENNDIRTIAAGSITASGRSSDTNPSWYVINNSNVDNINSTVATNNNYLGRPWSDYARVVFQNTYLGSNIKAAGWSTWSTSTPNTDHVVFEEYNNSGPGAAGPRASFSSSIT... | 125 |
A0CLA9 | 3.2.1.52 | ACT_SITE 312; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR001093-1" | MKFIIVIAILIVGTYQLMPMPKQFVKGSKSMKVINKCGIQFTNGNQYPEHVIELLRHYHSLMTSKNECNFEQALNFNLKNQGALKFHISLQNDEQLYWVNKTQQEAYILKIDEYLNIQIDAHNHWGLARALDTVHQLTENDRIEFLPLIIEDEPAYSFRGVMVDTARHFLPLKTLERTIDALAINKMNVMHWHITDDESFPLLLTNYSRITHTSKYSENEYYTKSDVSYLIEYASIRGVQIIPEIDSPAHVQSWGRNISDLEYIILNCGSTIKQYGQFDPTLDLTYDVVKSVFQDLSDMFSKVQFIHFGGDEAIKSCYNQ... | 170 |
Q9LUT0 | 2.7.11.1 | ACT_SITE 199; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MGCFGCCGGGEDFRRVSETGPKPVHNTGGYNGGHHQRADPPKNLPVIQMQPISVAAIPADELRDITDNYGSKSLIGEGSYGRVFYGILKSGKAAAIKKLDSSKQPDQEFLAQVSMVSRLRQENVVALLGYCVDGPLRVLAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWHQRVKIAVGAARGLEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAARLHSTRVLGTFGYHAPEYAMTGTLSTKSDVYSFGVVLLELLTGRKPVDHTLPRGQQSVVTWATPKLSEDKVKQCVDARLNGEYPPKAVAKL... | 99 |
K3XWJ4 | 3.1.3.48 | ACT_SITE 219; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR628472-1"; ACT_SITE 221; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR628472-1" | MRGAPPADSPGERTPSDSRFRGGGGADRRSRAGGLRRNGEERVAFWRVRASGGAGRAGLSGIWGLIGRDYPARFRSLFPGEGSSHVETFHAKSRCATPFLVGRQRFVLGTAALRCLLFFSPHPLAGSPSPCSDSSPQIAPSLTPCCASSSAALSPATVGASNPGPLGPPSSRCGDPPVRCWIGFIVCWSEMDEVVPALATGEASVDAVTEQPLKVYIWDMDETLILLKSLLDGSYAGAFDGVKDREKSVEIGKRWENLILELCDEHFFYEEIENYNEPYLNALSEYDDGRDLTSYDFEADCFSSPYDDVNKKKLAYRHRA... | 149 |
P50903 | 3.1.1.3 | ACT_SITE 169; /note="Nucleophile"; ACT_SITE 193; /note="Charge relay system"; ACT_SITE 280; /note="Charge relay system" | MLLLWILSLFLETVAGGEVCFDRLGCFSDNKPWAGTSERPRKGLPWDPSAINVRFLLYTNENPNNYQRITADSSVIRSSDFKTDRKTRFIIHGFIDKGEENWLADLCKALFQVESVNCICVDWRGGSRTLYSQASQNIQVVGAEVAYLINFLQSQLDYPPSSVHIIGHSLGSHAAGEAGRRTNGAIGRITGLDPAEPYFQYTPEIVRLDPSDAQFVDVIHTDGNPIIPNLGFGMSQTVGHLDFFPNGGLQMPGCQKNILSQIVDIDGIWEGTRDFAACNHLRSYKYYIDSITNPKGFAGFSCDSYSSFSSNKCFPCATGE... | 128 |
A0A9R1V9D1 | 3.1.1.11 | ACT_SITE 508; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MASDGGKKKKVIAMAVLLVVGAVVSTIVTVRRHKDIEINVRKAGGKKTGIIAATAVTTAATTATVIILCKHTDFKKVCEETLSRVGLKEPRDLVKANFNAAMESILVAIEKSYTLQVAAKDPMAAKAIEQCNELLHVSIEDLKRSVDQVNIFDLPKLKQNIIDLRVWLSGAVTWQETCLDAFENTTGDSKMSMWKFMETGNRLTRNSLAILDGVAELSIDVQKSPRKVPKPRPKPLTMPISVNWKADLTINPMALRQDTGNGMNNNPADSQPATVGGDSKPMTGNRRMLDQLDDDFQDPVVHSNLQMVGDSSSKDDEIPT... | 125 |
Q0UUW7 | 2.3.1.225 | ACT_SITE 117; /note="S-palmitoyl cysteine intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_03199" | MELSQLAVPSVYVLIFFLGYPSQWLLTQLEPRPLTKNELIFANVILVLIFITYTKSVFVDPGRIPKDWAEKQELGLSEEKKKKITRKWCRKCEAPKPPRAHHCKACKRCIPKMDHHCPWTSSCVSHTTFPHFLRFLVSTTVGLSFLQLLLFTRLSHLWNSRHLPASLGPSPFLLFHLFATTLANSLTLFAVGILALRNIWVLAINVTTIEGWEIERHRTLLRRARHFGGYLETPDGQAIRIKKQEFPYDIGILRNICQGMGSANPLMWFNPLAPSPSVQSALQFEVNGFEDEGTVWPPPDPDRSYKKVERGAEGEAFVFG... | 57 |
Q9SZD5 | 2.7.11.1 | ACT_SITE 469; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MKFFVLVLLLVLQFFSNKALSQSEEGEFGFNGYLYDNSGIAITNSKGLMKLTNSSEFSYGHVFYNSPVRFKNSPNGTVSSFSTTFVFAIVSNVNALDGHGLAFVISPTKGLPYSSSSQYLGLFNLTNNGDPSNHIVAVEFDTFQNQEFDDMDNNHVGIDINSLSSEKASTAGYYEDDDGTFKNIRLINQKPIQAWIEYDSSRRQLNVTIHPIHLPKPKIPLLSLTKDLSPYLFDSMYVGFTSATGRLRSSHYILGWTFKLNGTASNIDISRLPKLPRDSRSTSVKKILAISLSLTSLAILVFLTISYMLFLKRKKLMEVL... | 99 |
A0A072U9H8 | 1.11.1.7 | ACT_SITE 76; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAMVSASRSLFISFLLASLILVSSERVARPPAVRGLDYDFYRLSCPRIERIVRKHLEDVFEKDSGQAPGILRLFFHDCFSQGCDASILLNGVDGEDDEKQHDANFALREEALQTIENIRAIVRKQCPRVVSCADILVIAAREAVRQFGGPDIDVPLGRKDSLNFSVNSPDNLPVPFARTDELLTVFGSKKFDATDVVALSGAHTFGQAHCPTMFNRVIDSDPPIEPNFKKQLEATCPNEESLNAVNLDVRTPNTFDNMYYINLLNHQGVFTSDQDLASHPKTKEIVNLFASNQKEFFNKFANAFVKVSQLDVLTGNQGEI... | 14 |
A0A2R8YET7 | 3.1.3.48 | ACT_SITE 352; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR628472-1"; ACT_SITE 354; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR628472-1" | MEDPRGINGQSVQTSQASSDVAVSSSCRSMEMQDLTSPHSRLSGSSESPSGPKLGNSHINSNSMTPNGTEVKTEPMSSSETASTTADGSLNNFSGSAIGSSSFSPRPTHQFSPPQIYPSNRPYPHILPTPSSQTMAAYGQTQFTTGMQQATAYATYPQPGQPYGISSYGIKTEGGLSQSQSPGQTGFLSYGTSFSTPQPGQAPYSYQMQGSSFTTSSGIYTGNNSLTNSSGFNSSQQDYPSYPSFGQGQYAQYYNSSPYPAHYMTSSNTSPTTPSTNATYQLQEPPSGITSQAVTDPTAEYSTIHSPSTPIKDSDSDRLR... | 149 |
A0A8I6XE06 | 1.11.1.7 | ACT_SITE 84; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAPSSPLLAAAVALLVLALGSAVAYAAAEHEELRSRQPPVARGLSFHFYHGRCPGAESIVRKFVQDAVRKDKGLAAGLLRLHFHDCFVQGCDASVLLHGSAAEPGEQQAPPNLTLRPSALKAINDIRDQLEHHCHGAVVSCSDILALAARDSVVATGGPDYCVPLGRRDSARFATRDAVGSGLPRPSSNVTTLLDVFRKLGLEATDLVALSGGHTIGLGHCNSFEKRLFPLPDTTMSPSFVARLKRTCPTMGTDARAALDVRTTNVFDNKYFVNLVNQEGLFVSDQDLYTNAITQPIVEHFARSQGDFFDQFGVSMVKMG... | 14 |
K3ZCE0 | 3.1.1.11 | ACT_SITE 276; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MAVLAPLLLASLVSVATSSPPPSKDVQQASFAVNTPVKKPSHGGGQQASFVIGGDDGASSKVPPGSGAAGSFGEFIAENVQSYNVNKQIYAAKVKNGTGGKAVDAELSAAEAGAVRYVVSADGKGKFRTINDAIKAVPENNKKRVILDIRPGTYKEKVLVPYTKHFITFLGDPKQPPVIMWDDTAATRGKDGLPVGTVGSATVAVESDYFLASGIVFRNHAPMAAPGAKGGQAVALRVFGTKAAFYNCTIDGGQDTLYDHKGLHYFKGCLIKGSVDFIFGFGRSLYEDCSIVSVTKQVAVLTAQQRTRSIADAIESGFSF... | 125 |
B0BMY6 | 3.4.19.12 | ACT_SITE 127; /evidence="ECO:0000256|PIRSR:PIRSR623237-1"; ACT_SITE 130; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR623237-1"; ACT_SITE 340; /evidence="ECO:0000256|PIRSR:PIRSR623237-1" | MSRGIMPQPGAWPGAGCAETPAREAGAAARDGGKVTVGAQPRAATRCPAEHEEDMYRAADEIEKEKELLIHERGISAEPRLSVAPEMDIMDYCKKEWRGNTEKAMCMRKGYEEVSQKFTSIRRVRGDNYCALRATLFQAMSQLAELPPWLQDLELILLPEKLINKYTWIKQWKLGLKFDGKSEDLVERIKESLALLRKKWVSLAAMEAAEARQTACDELFTNEEEEYSLYEAMKFLMLARAIQLYDDKEKGKEVPFFSVLLFARDTSNDPEQLLRNHLNQVGHTGGLEQVEMFLLAYAVRHTIQVYRLSKYNTEEFITVY... | 175 |
Q75BN5 | 2.3.1.48 | ACT_SITE 380; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51" | MTISADSQAKKSKMLDGLDIKDIIQGDEQDGAGNGGSRRVHRPRDGNGPDYRIHKPMAAVGWLQGRIPSDVAEWGRWNAHVDFPDGTKNKVRIRYDPRKLYDFRRVLRASAAETGPPPHLDFEIYETENLLNMLDNESYPYRGAIANKKDYSTSKTTPTLRDRQFFQKLLFQSANAARTNGNTLLSFTEEEPKGRPSKAERAHKVSYIYFNDHEIKTWYTAPYPEEYSKNRILYICDSCLKYMNSKYIYYRHKLKCSMMHPPGNEIYRDGKISIWEIDGREQVIYCQNLCLLAKLFLNSKTLYYDVEPFVFYLLTENVKT... | 61 |
B3S1P8 | 1.11.1.24 | ACT_SITE 49; /note="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000239-1" | MSKAQVQKAAPNFAAKAVVDGKFKDIKLSDYLGKYLVLFFYPMDFTFVCPTEIIAFSERVEDFRSRNCEVIACSTDTEFSHLAWINQPRKEGGLGSMNIPILADPTHTLAKDYGVLLEDQGIALRGLFIIDGKGILRQITVNDLPVGRSVDETIRLVEAFQFTDEYGEVCPANWKPGKSTIKPNPNDSKAFFASQ | 12 |
A0A061GFG7 | 3.1.1.11 | ACT_SITE 381; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MATAHQPLLHRPKTSKVLPLIFSIAAIVCTAALVTIRLVKISSFTPLPDQVCLGAVDQKSCSALLSEVASNSTIKMKGVDVLHAFLEKSTAQMQNAINLANNFKHRINNPRDQAALADCLELMESSMDRIADSMVALGKKDVDSHSDAHAWLSSVLTNHVTCLDGVQGSARTLMEPGLNDLISRARTSLAVFVSISPGKTRFVDPSIDEFPSWVSSKDRKLLQALLNEIKANVVVAKDGSGNYKTLAEAVAAAPDKSKIRYIIHVKNGTYKENVEIGKKKKNLMIVGDGMNSTIITGSLNFVDGTTTFKSATVAAVGDGF... | 125 |
Q9M1Z5 | 2.7.11.24 | ACT_SITE 186; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MEPTNDAETLETQGEVTTAIWPSSQILKTTIDIPGTLSHDGRYIQYNLFGHIFELPAKYKPPIRPIGRGACGIVCSAVDSETNEKVAIKKITQVFDNTIEAKRTLREIKLLRHFDHENIVAIRDVILPPQRDSFEDVYIVNELMEFDLYRTLKSDQELTKDHGMYFMYQILRGLKYIHSANVLHRDLKPSNLLLSTQCDLKICDFGLARATPESNLMTEYVVTRWYRAPELLLGSSDYTAAIDVWSVGCIFMEIMNREPLFPGKDQVNQLRLLLELIGTPSEEELGSLSEYAKRYIRQLPTLPRQSFTEKFPNVPPLAID... | 104 |
P40479 | 3.1.3.48 | ACT_SITE 140; /note="Phosphocysteine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00160" | MNIYTSPTRTPNIAPKSGQRPSLPMLATDERSTDKESPNEDREFVPCSSLDVRRIYPKGPLLVLPEKIYLYSEPTVKELLPFDVVINVAEEANDLRMQVPAVEYHHYRWEHDSQIALDLPSLTSIIHAATTKREKILIHCQCGLSRSATLIIAYIMKYHNLSLRHSYDLLKSRADKINPSIGLIFQLMEWEVALNAKTNVQANSYRKVP | 149 |
A0A2R6X1R1 | 1.11.1.7 | ACT_SITE 70; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MTTTICRWIWSAISMAGLLAVTAVPSTASDAENYYSSTCPEATTIVRNMVTGFVKQDRNLAGALQRLHFHDCFVRGCDASVLLSSPFNTAEKDSISNKNSLRGFEEIDEIKAALESSCPGIVSCADILALTARDATVKAGGPSWSVALGRKDGFVSLQAEADKLPAPFMSYAQLAASFAAVGLSEQDMVALSGAHTIGRAQCGSVLSRLYDFNGVTNSTDPSMDKKLVKELKKKCPHGVQPGNFLPMDPTKNTFDHLYFTSVLAKRGLLGSDAQLLNSPVGLDLVTKYSQPGSSFFSDFAAAMVRMGSIQWATQGEVRIN... | 14 |
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