Entry stringlengths 6 10 | EC_number stringclasses 260
values | Active_site stringlengths 0 544 | Sequence stringlengths 20 2.05k | labels int16 1 260 |
|---|---|---|---|---|
G7IM29 | 2.3.2.26 | ACT_SITE 786; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MSPTTKILTANHRKNHSPKLTSSSSKMKKITKTKSSKLQFFVRMMWNCNTLVIRASREKTVESLLEQISSKTRIPIQHQRLIYEGKQLTLEQSLCECGIENDANLQLVGRLRSIACPKVWKATQYIVSLILRLCRGELVIGASRIIDDHLTYYINDSEYFSVFMFMEIPSLLVALYMSRYANACVADSVIKDFVRICLDLKDKKLQGVYLEVSLEFCELLRRARCKYDDPLYVFCRDSFSSLLTLVGRVNFQNPKGEVMLRGVFDCVHEIADELLRFLDLSMNCPTGEGFSFNFVLDFVKFSGHLRMGLAEQQATSDEFL... | 65 |
O67919 | 2.3.1.286 | ACT_SITE 107; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00236" | MENLNIVTLTGAGISAESGIPTFRGKDGLWNKFKPEELATPEAFFRNPKLVWEWYDWKRQLIAKAQPNEGHKILTKMEEEFPNFYLITQNVDGLHQRAGSKKVIELHGNIWKVRCVECGNERYEYTTPLPEIPPKCEKCGGLLRPGVVWFGESLPVDALSRAYELSREAHVFIVVGTSGVVYPAAELPFVAKENGAQVIEVNPEETPITKIADMHFKEKASTGLKKVYDYLREKYGSKG | 58 |
A0A0K9PIP0 | 3.1.1.11 | ACT_SITE 401; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MHAIITSSSNLNLLFIFLLSSIGIIRAATTWGTLSSSLVKQACSGTANYNSCTSRLGIEFESAGAQQETHGPFTVIHAAIKLTINEAIVATELVSKFTTMTTNFREQSAVHDCMELLDYSVHELGLSLVAMKKAHRLPGGIHRKGDLGAWLSAALGNQDTCMEGFQGTDGRLKHYIKGSLRQITILVTNVMAMYKRIGKIAPFDPQQQDRYGNESTNDLGVKANIGDSPSWMTSEEHSLVHHAHHPNRMKVDATVAQDGSGKFRSIMEAINDAPKHSLRRYVIYVKKGLYKENVEMKKNKVNILLVGDGMGITIISGDRS... | 125 |
Q7XUN6 | 2.7.11.1 | ACT_SITE 477; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MVLPKPEMPFFVLLLFLGLGCLRPAAATDERFVFNGFTGANLSFDGMATVTSNGLLMLTNGTNQLKGHAFFPSPLQFQRGPNSTAMQSFSTAFVIGIIGAFEDLSSHGMAFIIAKSKNLTSALPGQFMGLVNSANNGNATNHLFAVEFDTILNSEFNDMSGNHVGIDVNGLNSVDADNAGYYDDGTGDFKNMSLVSRRPMQVWVDFDGQTMQVNVTMAPLEVARPKKPLLSKIVNISSVIDDTAYVGFSSATGILFCRHYVLGWSFKMNGAAPALNISSLPSLPVTFPKPRSKTLEIVLPIASAVLVFAVAAAVFVFMRR... | 99 |
A9V5E8 | 1.2.1.12 | ACT_SITE 170; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR000149-1" | MACLSCGTRDTPLTTTSNMAIKVGINGFGRIGRIVMRAAVSNPNVQVVSINDPFMDVDYMVYMFKYDSTHGKYAGSVEAKDGKLVIDGTVINVHACMKPEEIPWGTDGVDVVVESTGVFTDKAGASAHLKGGAKKVVISAPSKDAPMFVMGVNEDKYDAASMDIVSNASCTTNCLAPIVKVLEDEFGIVEGLMTTVHAFTATQKPVDAPARKDWRSGRGCAQNIIPASTGAAKAVGKVIPAVDGKLTGMAFRVPTPDVSVVDLTCRLDKAASYDDIKAAMKKAAEGPMKGVLAYTEEDVVSMDFRGDPHSSIFDAKAGIA... | 22 |
A0A251T924 | 1.11.1.7 | ACT_SITE 129; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MYAYIRCWKGRFKHTKHQVKEPTKGNMMKTILVFLVASILVIGCMGGKGHGHHHGHGHGHGHGHGHGHGQGRGHGRGHGHGLGGGLQVHYYQNRCGSMGWVEKTVKDIVWNKVAADPTLAPKLLRLHYHDCFVRGCDASILLDPTQNNTEAEKTARPNRSLSGYEVIDEIKTKLEAACPETVSCADILALATRDAVSFQFKREMWPVFTGRKDGRDSLASEVSENLPSANANFTTLLTQFGNKKLNLNDLVTLSGAHTIGHSRCALVSRRLYNFTGIGDADPSLDPAYAQTLRKLCPTPVNPSTSLEMDPKSSLTFDSDY... | 14 |
Q4WMS5 | 2.3.2.26 | ACT_SITE 1784; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MSPRITRSAARLAADSPSSAGSGPSSIPAAGSAPTRKRKAHARRDPPLDVPEETNPQSPTRRTKRQRLASPPHPASTVSTSRRGTRNRPAMSQQGPSASSPEETTKKQSSPPPSRRKSSRHRGKVSQDRPSATQSPLPRRQKKRSSRTNSDVMMKEAEEELDSHERTASRESSPSNDSNDGTTPSGIDDDDDADLFHNSLFGSRSPLGLQSTLRALSGMMSGMSSRLREILCNLRMKEDPSIQLIALQELSDLLLVSNEDNLSGQFSPDPYVKELVTLMQPDQVGEENPEIMLLACRCLANLMEALRGSVANVVYGGAVP... | 65 |
Q12263 | 2.7.11.1 | ACT_SITE 156; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MAINGNSIPAIKDNTIGPWKLGETLGLGSTGKVQLARNGSTGQEAAVKVISKAVFNTGNVSGTSIVGSTTPDALPYGIEREIIIMKLLNHPNVLRLYDVWETNTDLYLVLEYAEKGELFNLLVERGPLPEHEAIRFFRQIIIGVSYCHALGIVHRDLKPENLLLDHKYNIKIADFGMAALETEGKLLETSCGSPHYAAPEIVSGIPYQGFASDVWSCGVILFALLTGRLPFDEEDGNIRTLLLKVQKGEFEMPSDDEISREAQDLIRKILTVDPERRIKTRDILKHPLLQKYPSIRDSKSIRGLPREDTYLTPLSESNSS... | 99 |
M4TB00 | 4.1.1.17 | ACT_SITE 361; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR600183-50" | MTMITQMELIGDSKVAIADGEVDAISMCQEIAHSYDQDNIDDAFMLVDLDVIFERFLLWKREMPMIEPFYAVKCNTDRVLVRTLAALGAGFDCASREEIDIVMDMGVRAEKIIYANPCKTRSFITHAKEKNVSMMTFDSVEELAKIAHLHPDAKMILRIAVSDPTARCPLNLKFGVDPVTKAPHLLVHAKELGVNVIGISFHVGSGCNDPTAFREALTHARHLTELGRGLGFDMNLVDLGGGYPGTLQQTSFEDIAAVIRSAVDEFLPPEFGVRLIAEPGRFFAAAPFTLVCNIIHATEVSAEKITKRPEDVDHRGFMYY... | 195 |
G1KHN2 | 2.7.11.1 | ACT_SITE 192; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000605-50" | MAGVFDLDLETEEGSDGEEPELGGLDVDPDLRCSGPDQVPGYYEEIEISENIVNNGPERIGPHCFELLRVLGKGGYGKVFQVRKVQGTNAGKIFAMKVLRKAKIACNAKDTAHTKAERNILEAIKHPFIVDLMYAFQTGGKLYLILECLSGGELFMQLEREGIFLEDTACFYLGEITLALGHLHSNGIIYRDLKPENIMLNSQGHIKLTDFGLCKESIHDGAVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTIDKILKGKLVFPPYLTPDARDLIKKFLKRNPSQRIGGGPGDAADV... | 99 |
F6WHK7 | 3.2.1.35 | ACT_SITE 149; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR038193-1" | MGIQKLTQIFFGSYVIYSRTCHLVITILLLPYYPALTFRAPPVVPDLPFVMGWNAPTEVCAKKFKVTLDLSLFSFVGSPQKRARNQNITIFYSDRLGYYPYINEKTGEAFNEGIPQLASLKKHLAKAKKDIDYYIPSDDKFGLVIIDWENWRPNWIRNWNTKHIYQTQSIELIHQLNIKLNDIEAWKAAKTDFEKAAKIFMQETLRLGKSLRPNHLWGYYLFPDCYNHDYKNPNYTGRCFEIEKGRNNDLYWLWKESTALFPSIYIETYSQKTQFFVRNRIQEAIRISQVVHFKNPLPIFVYARPVFIDASYQYLSEGDL... | 166 |
B9RPS9 | 1.11.1.7 | ACT_SITE 66; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MRGNIGYLGLIIFGLLAFTISTEAQLQMNFYAKSCPKAEKIVSDFVDEHIHNAPSLAASFIRMHFHDCFVRGCDASVLLNSSSTAGEQPEKAAVPNRTLRGFDFIDRVKSLVEDECPGVVSCADIITLVTRDSIVATGGPFWQVPTGRRDGVISRSSEATAIPAPFANITTLQTLFANQGLDLKDLVLLSGAHTIGIAHCSTISDRLYNFSGTGQADPNLDSEYADNLKARKCRSPDDTTTKIEMDPGSRKTFDLSYYSLLLKRRGLFESDAALTTNSVTLSFINQILKGSLQDFFAEFANSMEKMGRINVKTGSDGEIR... | 14 |
F2EAM8 | 2.7.1.11 | ACT_SITE 299; /note="Proton acceptor"; /evidence="ECO:0000256|HAMAP-Rule:MF_03186" | MALASPVDYAGTFTSSQKHHSFVMPGCNGLRCSTIGFGNKSRAAGHLVVRAMSMDRPKLDFSNSNWKDQFQEDFDRRFSLPHLTDIIDVESRPTTFSLKSRAPLENVTGSSEESWNGYVNDDDRALLKVIKFASPTSAGADCIDPDCSWVEQWVHRAGPRKQIYFEPQCVKAGIVTCGGLCPGLNDVIRQIVLTLEKYGVKNIVGIQHGFRGFFEDHLAEVPLNRHVVQNINLAGGSFLGVSRGGASISDIVDSIQARRLDMLFVLGGNGTHAGADAIHDECRKRKLKVSIIGVPKTIDNDILLMDKTFGFDTAVEAAQR... | 84 |
A0A2G2YBB0 | 2.1.1.37 | ACT_SITE 547; /evidence="ECO:0000256|PROSITE-ProRule:PRU01016" | MPSKRKDSPVTKPEKSSESRKSKRLAERPDPVLQPQFDDSDFASEPVSATKRKSVRRKIPESTPIVVESEKWKKRAVDKAESDDDFVSESKLLMSRATVKAENVVDTAASESDFVEEEDEIEQGSLKKNLSVSPSKRKPKRAEKVKDEECTLAGDPVPDAEARLKWPHRYNKGKANGTKSLNGQVDSDQLIQAKRHFSLAEVDGQVYYLEDDAHVKAADGEDDYICKIVEFFEAVDGMQYFTAQWFYRAKDTVIKSHDQFIDKKRVFLSEIKDDNPLDCLVTKLKIVPVPSNATFQFKENVKSTCDFYYDMKYLIPYSSF... | 47 |
Q9V6K3 | 2.7.10.1 | ACT_SITE 580; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028" | MAAGQWVGVVERVLRGMVLKWGANLAVLGLCVFLFASATHANSLNAIEEPVTRRHHQRHHEREREENGYCAPYSGKVCKEYLTGQVWYSLEDPTGGWKNEQVTTALWDELISDLTGLCREAAEKMLCAYAFPNCHMEGGRAVKAPLCFEDCQATHLQFCYNDWVLIEEKKERNMFIKSRGHFRLPNCSSLPHYNASMRRPNCSYIGLTELKESEVSYDCRNGNGRFYMGTMNVSKSGIPCQRWDTQYPHKHFQPPLVFHQLLEGENYCRNAGGEEPHPWCYTVDESVRWQHCDIPMCPDYVDPNAVDLNTPIKMEKFFTP... | 97 |
A0A3Q7EGR7 | 1.11.1.7 | ACT_SITE 66; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MEGGILKFLFFTILVFVAIGHSNGQLRKDFYKSSCPQAEQIVQNITWKRVATNSTLPAKLLRMHFHDCFVRGCDGSILIDSTANNSAEKAAIPNLSLGGFDVIDEIKTALENTCQGVVSCADILTLAARDSVSFQFKKPMWEVVTGRRDGRISKSSEALSEIPSPFFNFTSLKQSFANKSLTVHDLVVLSGGHTIGVGHCNLFSNRLYNFTGKGDSDPSLNSTYVTFLKTKCQSLLDNTTIVEMDPGSSLTFDNNYFSVLKQQKGLFQSDAALLTNKGAKNIVDEMLIDGKFFTEFSQSMKRMGAIGVLTGSNGEIRKKC... | 14 |
A0A3B3HFJ1 | 2.7.11.25 | ACT_SITE 274; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038165-50" | MSGTCIHEPRAPSPSLSGFSTPISEPPYRRLDGDTPACTPETDLTPTQCVLRNVLSIDTGGQGAPCGSSPTPSDGPSAQFDNSVLKLHEHEACHCGGAEADHSPEAGAVRSQSESIRLQSGSGGFLEGLFGCLKPVWTMIGKAYSTEHKHNHEESWEVPFEEISDLQWVGSGAQGAVFLGKFHGEEVAVKKVRDIKETEIKHLRKLKHPNIITFKGVCTQAPCYCILMEYCAQGQLYEVLRAGRKITPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITHDDLVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVI... | 105 |
A0A8J0PYE6 | 1.8.1.9 | ACT_SITE 571; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000350-2" | MPPTGRDLLQARVKELIDSNRVMVFSKSFCPYCDRVKDLFSSLGAEYHSLELDECDDGSDIQEALQELTGQKTVPNVFVNKTHVGGCDKTLQAHKDGSLAKLLDDNSVTYDYDLIVIGGGSGGLACSKEAASFGKKVMVLDFVVPTPQGTSWGLGGTCVNVGCIPKKLMHQAAILGQSLKDSRKFGWEYEEQVKHNWETMREAIQNYIGSLNWGYRVALRDKQVRYENAYGEFVESHKIKATNKKGKESFFTAEKFVVATGERPRYLNIPGDKEYCITSDDLFSLPYCPGKTLVVGASYVALECAGFLAGIGLDATVMVR... | 37 |
A8B7B3 | 3.5.4.5 | ACT_SITE 60; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR606262-1" | MPITREQRSALIKAAIEGSEHAYIPYSKYKVGAAILTESGEIFKGCNVENAAYPIGVCAERTAVVKAISEGKKDMVACAVVTRDGGSPCGMCRQTLNEFNPKMHMILAKLDGEVITEMPLDELLPLGFGPANLL | 187 |
Q6NKW9 | 3.2.1.39 | ACT_SITE 119; /note="Proton donor"; /evidence="ECO:0000250|UniProtKB:O22317"; ACT_SITE 265; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:O22317" | MSNLLALVVGFVIVIGHLGILVNGLGVNWGTMATHKLPPKTVVQMLKDNNINKVKLFDADETTMGALAGSGLEVMVAIPNDQLKVMTSYDRAKDWVRKNVTRYNFDGGVNITFVAVGNEPFLKSYNGSFINLTFPALANIQNALNEAGLGNSVKATVPLNADVYDSPASNPVPSAGRFRPDIIGQMTQIVDFLGKNNAPITINIYPFLSLYGNDDFPLNYAFFDGAEPINDNGIDYTNVFDANFDTLVSSLKAVGHGDMPIIVGEVGWPTEGDKHANAGSAYRFYNGLLPRLGTNKGTPLRPTYIEVYLFGLLDEDAKSI... | 167 |
Q7XJ02 | 1.11.1.11 | ACT_SITE 118; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00297" | MAAQRLAALHAAAPSAFSSTSSASHGRPAARSSTTALLPVALPRASATLRAAPSRLLPQEAKAAGSGRSVMCMASASASAASAAVASGAAELKAAREDIRELLKTTHCHPILVRLGWHDSGTYDKNIKEWPQRGGANGSLRFDVELKHGANAGLVNALKLVQPIKDKYPNISYADLFQLASATAIEEAGGPKIPMTYGRIDVTGPEQCPPEGKLPDAGPSAPADHLRKVFYRMGLDDKEIVVLSGAHTLGRSRPERSGWGKPETKYTKNGPGAPGGQSWTAEWLKFDNSYFKEIKEKRDQDLLVLPTDAALFEDPTFKVY... | 11 |
F7ESB5 | 2.7.10.1 | ACT_SITE 1054; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MKRASCALSLWLWVGIVSEADLASGYSMTPPILSITEEEHVIDSKDTLTITCRGQHPLQWSWPGGQENPAWGEKESQSKAPVEVGGEQMVREEDCEGTDSRPYCKTLVLTGTQANDTGSYSCYYKYIKARIEGTTAASTYVFVRDFEQPFINKPDTLLINKKANTWVPCLVSIPDLNITLHSQSSDIYPDGRTILWDNKKGMLVPTALIRDALFIQCQTFLQGSIFKSNFFLVHVTGNELYDIQLFPKKALELLVGEKLVLNCTVWAEFNSGVNFQWDYPGKQKERAVAELPERRSQQTHTELSSILIIQNVSQQDLGKY... | 97 |
E3KF66 | 2.1.1.33 | ACT_SITE 265; /evidence="ECO:0000256|HAMAP-Rule:MF_03055" | MGANKKKRNFSAVDSSNQPNKKSTMTQSAADQAKEKLPHIMPRKRFYRQRAHANPFSDHNLDYPARSEEMDWSKHYPHFFQAPNSQTTIDHKEEGGEEEKNGVCTALADSSKKVVEFADVGCGFGGLLVAMAPLFPEKLMLGLEIRPHVCQYVEDKILALRAQQKIIQQQSSSTGEGTESVFELPSLPKSVPQNDKQIEQDADPVTNQASNEVTPDEELDDEAPIWVPKPGRFENVSVIRANAMKFSPNFFRKHQLSKMFFLFPDPHFKARKHKARIISPTLLSEYGYILRPNGIIYTITDVKDLNVWMVKHLSEHPLFK... | 45 |
Q9K3U0 | 2.7.6.1 | ACT_SITE 201; /evidence="ECO:0000255|HAMAP-Rule:MF_00583" | MTGIKTTGEKKMMFFSGRAHPELAEEVAQQLGVGVVPTKAFDFANGEIYVRYQESARGADCFLIQSHTAPINKWVMEQLIMIDALKRASARSITVIVPFYGYARQDKKHRGREPISARLIADLMKTAGADRILAVDLHTDQIQGFFDGPVDHLFALPLLADYVGAKVDRSKLTVVSPDAGRVRVADRWCDRLGAPLAIVHKRRDKDVANQVTVHEVVGDVKGRICVLVDDMIDTGGTICAAADALFAHGAEDVIVTATHGVLSGPAADRLKNSKVSEFVFTNTLPSASELELDKITVLSIAPTIARAVREVFEDGSVTSL... | 114 |
A2EIF8 | 2.2.1.1 | ACT_SITE 406; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR605478-1" | MEADNLAVNTIRCLAADIVSKANSGHPGAPLGLAPAAHVLWSKFYSYEKDWINRDRFVLGPGHASALMYSLLHLYQRELTIDDLKQFRQLHAKCAGHPEHYLIHDVEATTGPLGQGIGYAIGMAALELNLAARFNKPDFPVFNHKVFAFVSDGEMMEGVQAETASWAGHQKLDNLIVLYDDNHITIDGNTNLAFTEDVLARYRAYGWHTLVVENADKDLEAIEKAINQALELKGAPVLIDLKTTIGFGSEVANTPKVHGTPLNKDQLAALKKFFGFNPEESFVVPEQVYKLYDGVREKAHQKAEAWRAMFADYAKKYPEE... | 51 |
F7BKX1 | 3.5.1.23 | ACT_SITE 143; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR017632-1" | MRFCAFLTAAAAALATVCVLAQRAPPFTEDCRKSTYPPSGPTYRGPVPWYTINLDLPPYKRWHEVITDLTPEVRHIVKDLLDMVNAFFPSGKVTKMVDERLPAMLGVLPYPFEEEIKGIADVSGIPLGEIISFNIFYELFTFCTSIIAENKKGHLFHVRNMDFGIFLGWNMNNNSWTVTENLKPLTVNLDFQRNNQTIFKATSFAGYVGTLTGMKPGVFSLTLNERFSSNGGYMGILEWILGQRDEMWIGFLTRRVLENATSYEDAKNMLIKNKILAPAYFIVGGNKSGEGCVITRGRKDTPDVYELRPKEGRWFLVQTN... | 182 |
A0A8R1Y5I1 | 2.3.1.48 | ACT_SITE 624; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR602717-51" | MTTPGSEKGKLTDSLSAFFTPTPGGRRRKTTINTHEDSTSDEEPDGRASKLMGPLSGEVGTEGAGGSGTASKTTPSSTTSSSHHHHRRAEEQLHDALSPYFSAASGKRRSAVKGEYARMQQGGRRRVRAHAARRGRRRRRRRQSGRALEWRRGHAVARRRRRRTVARPQLAEVLAPRTPAQESIGRVDTGAGRIPNVRLDERRREGRRGRGRGGGAGAEDGRSLASAQVAEHVTLQEERRRRWGGVEDNSASAALFSSPDDRRGGKGQRKVKKEIESDESEDDAPLRKNKSSRHPPPPQASTATTSKSPLHKRIKRELRS... | 61 |
Q9LVK9 | 7.6.2.1 | ACT_SITE 425; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000250" | MGRRRIRSRIRKSHFYTFKCLRPKTLEDQGPHIINGPGYTRIVHCNQPHLHLAKVLRYTSNYVSTTRYNLITFLPKCLYEQFHRVANFYFLVAAILSVFPLSPFNKWSMIAPLIFVVGLSMGKEALEDWRRFMQDVKVNSRKATVHRGDGDFGRRKWKKLRVGDVVKVEKDQFFPADLLLLSSSYEDGICYVETMNLDGETNLKVKRCLDVTLPLERDDTFQSFSGTIKCEDPNPNLYTFVGNLEYDGQVYPLDPSQILLRDSKLRNTSYVYGVVVFTGHDTKVMQNSTKSPSKRSRIEKRMDYIIYTLFALLVLVSFIS... | 259 |
P15975 | 3.4.19.12 | ACT_SITE 41; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01035"; ACT_SITE 301; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01035" | MAWVKFLRKPSGNLGKAYQAGSLLSLAPTVGLLNEPGQNSCFLNSAVQVLWQLDIFRRSLRALTGHICQGDACIFCALKTIFAQFQHSREKALPSDNIRHALAESFKDEQRFQLGLMDDAAECFENILARIHFHLVPNRDADMCTSKSCVTHQKFAMTLYEQCVCRSCGASSDPLPFTELVRYISTTALCNEVERMMERHERVKPEMFAELLQAANTADDYRKCPSNCGQKIKIRRVLMNCPEIVTIGLVWDSEHSDLTEDVVRSLATHLYLPGLFYRVTDENATDSELHLVGMICYTSRHYCAFAFHTKSSKWVFFDDA... | 175 |
A0A1U8LM42 | 1.11.1.7 | ACT_SITE 67; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MEPSYIFLTMAVTLLSMPPTGFGQGTTRVGFYSKTCPRAESIVKSTVESHFRSNPAIAPGLLRMHFHDCFVNGCDGSVLIDGPNTERKAVQNSLLRGFDVIDEAKAKLEAACPGVVSCADILALAARDSVVLTKGINWKVPTGRRDGKLSLQSDAAKLPGFTDSIESQKQQFARFGLNTQDLVTLVGGHTIGTAACLVFNYRLNNFTNGGPDPTINPSFLPQLRSLCPQNGNNFRRVDLDTGSANKFDTSFFTNLKNGRGVLESDQKLWTDASTRTFVQQFLGEKGVRKLNFGKEFAKSMVKMSNIGVKTGSNSEIRRVC... | 14 |
Q9UVF4 | 1.1.1.8 | ACT_SITE 253; /note="Proton acceptor"; /evidence="ECO:0000250" | MSALLRSSLRFKHMSAVNRLTQQLRLLTASAPLSAANTAGKAPFKVAVVGSGNWGTTVAKIVAENCTAHPELFEPEVRVWVREEKVNGKNLTDIFNAEHENVRYLPKIKLPHNLIAEPDLLKAVEGANIIVFNLPHQFLAGVCKQLKGHVNPKARAISCLKGLDVTPQGVYLLSDVIENETGLHCGVLSGANLATEIALEKYSETTVAYNRPKDFFGEGDVTNDVLKALFHRPYFHVRCVQDVAGVSIGGALKNVVALCAGFVEGKNWGDNAKAAIMRRGMLEMINFSKRFFPETDINTLTVESAGVADLITSCAGGRNF... | 7 |
B7P7H9 | 3.4.19.12 | ACT_SITE 38; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 140; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331"; ACT_SITE 155; /evidence="ECO:0000256|PROSITE-ProRule:PRU00331" | MYQSCLRLVDRLLRKDQKPGRPGLAPPVYHERQVKELCALHALNNLFQDASAFSKGSLDDICHSLSPDHLVNPHKSVLGLGNYDVNVIMSALQLRGYEAIWFDKRKDPTCIDLSKIVGFILNVPSEMKFGFLQFPLSRKHWIAVREVEGTFYNLDSKLEAPSPIGKAPELLQYLREQVKCKDREIFVVVTQEIGRVKGCYQDA | 175 |
Q10GB1 | 2.7.11.1 | ACT_SITE 129; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MEQYEVLEQIGKGAFGSALLVRHKVEKKKYVLKKIRLARQTDRTRRSAHQEMQLIATVRNPFIVEYKDSWVEKGCYVCIIIGYCEGGDMAEAIKRATGDHFSEEKLCKWLVQLLMALDYLHANHILHRDVKCSNIFLTRDQSIRLGDFGLAKILTSDDLASSVVGTPSYMCPELLADIPYGTKSDIWSLGCCIYEMTALRPAFKAFDMQALISKITKSIVSPLPTRYSGAFRGLIKSMLRKSPEHRPSAAELLKHPHLQPYVLQVHLKSSPARNIIPSHQSPIDKVKKMTFPTESMCRSKGRRNSLGNERIVTFSKPSPE... | 99 |
A0QWW2 | 1.2.1.12 | ACT_SITE 159; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:P00362" | MTIRVGVNGFGRIGRNFYRALATQKAEGKNTDIEIVAVNDLTDNATLAHLLKFDSILGRLPQDVSLEGDDTIVIGDTKIKALEVKEGPAALPWGDLGVDVVVESTGIFTNAAKAKGHLDAGAKKVIISAPATDEDITIVLGVNDDKYDGSQNIISNASCTTNCLGPLAKVLNDEFGIVKGLMTTIHAYTQDQNLQDGPHKDLRRARAAALNIVPTSTGAAKAIGLVLPELKGKLDGYALRVPIPTGSVTDLTAELAKSASVEDINAAMKAAAEGPLKGILKYYDAPIVSSDIVTDPHSSLYDAGLTKVIDNQAKVVSWYD... | 22 |
W1NRS5 | 3.4.21.89 | ACT_SITE 133; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"; ACT_SITE 183; /evidence="ECO:0000256|PIRSR:PIRSR600223-1" | MPSLQLSPPSCYLNPNFAFTKPGCSKSQALNPVIGLGTTSRNCNFRRIYCRGKGAEDAEAKPVIEKSRGGGGNGDNGGFNGGNGDESEEKGKLQLPEWINLTSEDAKTVIAALAVSLAFRSFIAEPRYIPSLSMYPTFDVGDRIVAEKVSYYFRKPCVKDIVIFKSPPVLQEVGYTDGDVFIKRVVAKEGDTVEVHGGKLIINGVEQSEDFILEPPAYDMSPVHVPDNSVFVMGDNRNNSYDSHIWGPLPSKNILGRSVFRYWPPARFGSTVREESCSDKKQESTVAS | 178 |
W5MIN0 | 2.7.10.2 | ACT_SITE 1004; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000636-1" | MSRISAMELGRQLCGKMRKTKKTEAIISTPMKGLEIHFYLCDSHQLEYLSGSYLVEDLCIEAAKKCGISPLCYNLFALYDESRNIWYPPNHTFTIDEGTAIKLHYRMRFYFSNWHGTNENESLVWRHSLHKQKTEYGPKKVPEGTPLLDAASLEYLFAQGQYDFLKGLAPVRSPQNENETHDIENECLGMAVLAITHHTMRKSMAGSAGETRKQINYKKYIPETLNKAIKQRNFLTRIRINNVFKSFLNEFNNKTVTDSNVTMHDLKVKYLSTLETLTKHFGTEIFETSMLQICVENESCLPYNKEQPLYEIQVSGKMGI... | 98 |
Q8PBX7 | 2.7.7.7 | ACT_SITE 153; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR606309-1" | MRQIILDTETTGLEWRKGNRVVEIGAVELLERRPSGNNFHRYLRPDCDFEPGAQEVTGLTLEFLADKPVFAEVVEEFLAYIDGAELIIHNAAFDLGFLDNELSLLGDQFGRIIDRATVVDTLMMARERYPGQRNSLDALCKRLGVDNSHRQLHGALLDAQILADVYIALTSGQEEIGFGAMDAGQHAEGGEGMIAFDPSLLLPRPRVVVTPSELQAHEARLERLRKKAGRALWDAPELDEVAVAS | 121 |
P16577 | 2.3.2.23 | ACT_SITE 85; /note="Glycyl thioester intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00388" | MSSPSKRREMDLMKLMMSDYKVDMINDGMHEFFVHFHGPKDSIYQGGVWKVRVELTEAYPYKSPSIGFTNKIYHPNVDEMSGSVCLDVINQTWSPMFDLVNIFEVFLPQLLLYPNPSDPLNGEAASLMMRDKNAYENKVKEYCERYAKPEDISPEEEEEESDEELSDAEGYDSGDEAIMGHADP | 64 |
A9TF79 | 2.7.11.1 | ACT_SITE 131; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MDIPSMHDHDRYELVKDIGSGNFGVARLMRDKKTRELVAVKYIERGEKIDENVQREIINHRSLRHPNIVRFKEVMLTPTHLAIVMEYAAGGELFERICNAGRFSEDEARFFFQQLISGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSLLHSQPKSTVGTPAYIAPEVLSKKEYDGKIADVWSCGVTLYVMLVGAYPFEDPEDPRNFRKTIGRILSVQYSIPDYVHISVECRHLLSRIFVANPAKRINIQEIKNHEWFLKNLPADLVDLADRSYDFEDPNHPPQSIEEIMRIISEARVLGTGATGDYFGD... | 99 |
A0A8V0XFP0 | 3.1.3.48 | ACT_SITE 327; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR628472-1"; ACT_SITE 329; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR628472-1" | MEMQDLASPHSRLSGSSESPSGPKLDNSHINNNSMTPNGTEVKTEPMSSSEIATTTTTTTDGSLDNFSGSAIGSSGFSPRQTHQFSPPQIYPSNRPYPHILPTPSSQTMAAYGQTQFTTGMQQATAYATYPQPGQPYGIPSYGIKTEGGLSQSQSPGQTGFLSYGASFSTPQPGQAPYSYQMQGSSFTTSSGIYAGNNSLTNSTGFNSSQQEYPSYPSFGQGQYAQYYNSSPYPSHYMTNSNTSPTTPSTNATYQLQEPPSGITSQAVTDPAAAEYSTIHSPSTPIKDSDSDRLRRSSDGKSRGRGRRNNNPSPPPDSDL... | 149 |
E7EZI4 | 2.3.1.225 | ACT_SITE 159; /note="S-palmitoyl cysteine intermediate"; /evidence="ECO:0000250|UniProtKB:Q14AK4, ECO:0000255|PROSITE-ProRule:PRU00067" | MTNLNCFGRHRRRTAPHNATGSRSELVAPPIHSRINGWSSPLHSFQFIALLIFSFMAIVAFGIYVPLLPAPWSYAAYALIGSAFVLHLFSHVTAVTIDPADVNVRRRKDYSSPMPTFDNSKHPHVIDNLHCTLCEVDVSPKAKHCSTCNKCIADFDHHCKWLNNCVGGRNYWFFFTAVSSAVIGVILLIPLVLFVFIEHYVNPAVLRTAPQFQTVKGNGTWLVFLPVAPVETSSISLLVVSFITALLSLAALLLLCHLLCFHIYLLSQGISTYEYIVRKRQSPNPKEKQQVPPALPSNGATAQSLELQEPPLNCDAPLSS... | 57 |
A0A2K3E0J5 | 3.4.19.12 | ACT_SITE 333; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR016308-1"; ACT_SITE 903; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR016308-1" | MSVVDEAALAAVRAHMKSVRIPGFHDKVYKDECMFSYDDPESPGGLYVNLATLQGFGESFLPLDHSRTGGGLYLHLVHRRVPLPKAEVEAARQAAQAAGQLLLNAPTYRLDKAMALVVVNGPGPEQRLRVPLPCPDLPERVLQAIDAVVKHESVTQAEALAVFEEPRRVSKYAAGLEQLNTGRKISPNPADWRCDETGVTENLWLNLSTGFIGSGRKNWDGSGGNGAALRHFEAGGRKYPLVVKLGTITPHGADVYSYAPDEDDMVEDPGLAQHLAHWGIDIMQMEKTEKTMSELQADLNTGYEFSRITEAGAALVPLAG... | 175 |
A0A0K9NNF0 | 3.1.3.48 | ACT_SITE 14; /note="Nucleophile"; /evidence="ECO:0000256|PIRSR:PIRSR628472-1"; ACT_SITE 16; /note="Proton donor"; /evidence="ECO:0000256|PIRSR:PIRSR628472-1" | MSNTEQNVNVYVWDMDETLVLLKSLLEGSFAKVYNGSKDLKRGMEIGKQWENSILQLCDDLFHYNHIEEYNMPFLEYLREHDDGRDLSDYDFSKDNFGFSHDNSFQRKLAYRFRDISQIYSKGLKSVLDEEKIKLWEDLYDATDIYTDRWLSSAKDFLKQLSCKAKDFGSQDTFSDSASNFNDINCQTINVLVTNGSLIPSLAKCLLFRLDDPISYENVYSSWEVGKLQCFSWIKEKYGGPSVRFCAIGDGSEECVAAEKMRWPFVSIDIDPKGTHRFPGLQTKTLRFYMDVIYGEQPKHENDKDNNLPSCVIFNVMGKS... | 149 |
F7DIG7 | 3.2.1.143 | ACT_SITE 749; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 767; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 768; /evidence="ECO:0000256|PIRSR:PIRSR607724-1" | MSAGPGCKPCRKRARCGAPKSPPPTASDPLSQPAGKRQVSSSLGDPGQPTLCPLWQRTPPSSPSTGSPGPAVPRLHSVDSGGKLGNKVFKQKTITSWVDTKGFKTRSKSLQSKDTIIKAGSKMSSVQKDNLFQHNMEKLENVSQLSHPNSSLDKSTKHFNHPLTSSTCNWQSEVKQKELLETEPQEVTLVADQFRNANVDQSPQSDDQIHIDCEENRDNRQLLLTPVKIENSKQPVKDAQPREASDNLQQSKCCQPDDTIVASQQEDVDVVPESPLSDDGCGDILTDQKNIGKMSGQESPAESPPFEKESEPESPMDVDN... | 159 |
Q9VPK7 | 5.4.99.25 | ACT_SITE 309; /note="Nucleophile"; /evidence="ECO:0000255" | MKNQDLVEYLRSCGVCEICQLRYLKARGAEYRNINETLQKLDVKLNENVENEELVISEGSQPSKRARLGVCSTCLGLFSKDFQNELLSSILASDFAKYDCQKIVLAICLPMSLQLRQLAMWFALRRRFGPSIDENNPPDVPIKEAVKLILHPIICEKLAKVYDANGLMINIDLTHSLEGEEVEKLVKLNKEAFPAKASHQKRIEISRGLLEKQYQPSKVKAETYEKYFQIPCSNVEESIKLTSIDLQGPLICVAGRYRKLSRELSHTPWILNGQRLMEDSIEEIIIRHVGPHFTEKLGKITFMSSGREDVDVRCLGKGRP... | 218 |
Q09845 | 1.1.1.8 | ACT_SITE 236; /note="Proton acceptor"; /evidence="ECO:0000250" | MTVAALNKLSALSGSIQKSFSPKLISVGIIGSGNWGTAIAKICGENAKAHPDIFHPQVHMWMYEEKIQHEGKECNLTEVFNTTHENVKYLKGIKCPSNVFANPDIRDVGSRSDILVWVLPHQFVVRICNQLKGCLKKDAVAISCIKGVSVTKDRVRLFSDIIEENTGMYCGVLSGANIASEVAQEKFCETTIGYLPNSSVNPRYTPKTIQALFNRPYFRVNIVEDVPGVALGGALKNIVAVAAGIIDGLELGDNTKSAVMRIGLLEMQKFGRMFFDCKPLTMSEESCGIADLITTCLGGRNHKCAVAFVKTGKPMHVVEQ... | 7 |
G1KTY1 | 2.7.10.1 | ACT_SITE 845; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000619-1" | MGAPWLSRGPLPLLLLALGLLARGSCAAADEKRVCQGTSNRLSQLGSVEDHYNSLKRMYEDCEVVLGNLEITCLEPNYNLTFLKSIQEVAGYVLIALNTVKVIPLENLQIIRGNTLYENAALTILLNYNEIEGLEELPMRRLAEILNGGVKIVGNPYLCNINNILWNDIIESTKGFLLFDTVERKDTLPAISNKTCLPCHPNCTSGHCWGPDLENCQILTKIGCAEQCSGRCKGKLPSDCCHTQCAAGCTGPKESDCLACRKFWDDATCKESCPPLQVYNPTAYQLEDNPDGKYSFGATCVKKCPHNYVVTDYGSCVRSC... | 97 |
A0A251NG67 | 1.11.1.7 | ACT_SITE 93; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MQWKESGSSKSIYKQSSGHVLVKSEEAITTDMKATGSFFLVILVMILPVQGQLKTLFYSSSCPKAEATIRSTVESYFNKDPTIAAGLLRLHFHDCFVQGCDGSVLIKGSSAERNALPNLGLRGFEVIDDAKAQLEALCPGVVSCADILALAARDAVDLSDGPSWSVPTGRRDGRVSLSSQASNLPSPLDSVAAQRQKFAAKGLDDHDLVTLVGAHTIGQTDCTFVRYRLYNFTATGNSDPTINQAFLAQLQALCPKDGDGSKRVALDIGSQTNFDVSFFKNVRDGNAVLESDQRLWGDASTRNIMQNYAGNIRGLLGFRF... | 14 |
D8SES0 | 1.11.1.24 | ACT_SITE 73; /note="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity"; /evidence="ECO:0000256|PIRSR:PIRSR000239-1" | MASCVSRFLGLHCGVGFTPPAPRQFRPVAKISVGQRMPPFTLRDQDGTLVNLLDFKYKPLVIFFYPADNTPACTREACAFRDSYREFKKAGAEVLGISADGQETHKEFRQKHDLPFTLLCDSSDKLRKELEIPGEFFGALPGRETYVLDRKGIVRMVFNDQYAAEQHVEEALKAIRTMTKRGFGG | 12 |
O94091 | 3.1.1.3 | ACT_SITE 196; /note="Charge relay system"; /evidence="ECO:0000250|UniProtKB:W3VKA4"; ACT_SITE 348; /note="Charge relay system"; /evidence="ECO:0000250|UniProtKB:W3VKA4"; ACT_SITE 381; /note="Charge relay system"; /evidence="ECO:0000250|UniProtKB:W3VKA4" | MRGIAVFLAFISLIFASPLTVKSPLVDDFYTAPDGYESAKLGEILKLRKTPSKLSSMFFEIDIKNSWQLLVRSEDSFGNATAIVTTVIEPYNADPSKVLSYQTFEDSANIECSPSYGMQYGAPWSTVATQIDMALMVPMLKQGYYVVSPDYEGPKSTFTVGRQSGKATLDSIRAILKSNKFTGIKSDAKVAMWGYSGGSLASGWAAALQPKYAPELKKNLIGAALGGFVTNITATAEATDGTLFAGLVPNALSGLANEYPEFKEILYQKVSKAATDNLRQGTEHCIGGAILYFAEDQYFTGDDRAFPGGYGLLKEEVVNK... | 128 |
A0A1S4DPR2 | 3.1.1.11 | ACT_SITE 175; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MEGKEMGIFRIILVMFWWGAGNCMTFSSTVAEDGTGNFTTITDAVNAAPSQSATLFFIHVKAGTYNENVVVPNYKTNICLVGDGMGITIISSNKSGSSVAGTATLGVYGKGFIGMKMTIRNTAGAGAGQSAALTSAAFHGFASYYQCRFESFQDTIFAQVGAQFFRECEVYGTIDFISGDGQAIFQNSVVYARTPVPGQEVTIIAAGLDNITTNPGLILQNCTITPAPDFNKSAVKSYLGRPWKNLGRGVVMSSFIDGFIDPQGWLQKPDVANTYFAEYNNRGPGSNTTGRLNWSKVIDKTEASKFTVRNFLQGDKWIPD... | 125 |
A0A9R0JK16 | 3.1.1.11 | ACT_SITE 300; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MAQTMVLQAKNWAQSSSLDDSSLNNNNTKNYHQIRMAMVDCAKLYDQAEPRLARLLEKDGEYSHDDALAWLSGATTSHRTCLDGLREKGVVEEHHPMSQNLTMVLNEALAFHAKKPRFGSKPKAQGVPKGRPFAGRLTSWNTATSKADIVVARDGSGNYRTIKEAVDALVRMRVRGETRVIVYVKAGVYDETVEIPRHLQNVMFVGDGMGKTVVTGRRNVIDGGTTVNSATFRVFGDGFWGRDMTFENTAGPQKHQAVALMVSSDQSLFYRCSFQGYQDTLYVHSLRQFYRDCHVYGTVDFIFGNAAVVLQNCDIFVRKP... | 125 |
O54827 | 7.6.2.1 | ACT_SITE 431; /note="4-aspartylphosphate intermediate"; /evidence="ECO:0000250|UniProtKB:Q9HD20" | MERELPAAEESASSGWRRPRRRRWEGRTRTVRSNLLPPLGTEDSTIGAPKGERLLMRGCIQHLADNRLKTTKYTLLSFLPKNLFEQFHRLANVYFVFIALLNFVPAVNAFQPGLALAPVLFILAVTAIKDLWEDYSRHRSDHEINHLGCLVFSREEKKYVNRYWKEIRVGDFVRLCCNEIIPADILLLSSSDPDGLCHIETANLDGETNLKRRQVVRGFSELVSEFNPLTFTSVIECEKPNNDLSRFRGYIMHSNGEKAGLHKENLLLRGCTIRNTEAVAGIVIYAGHETKALLNNSGPRYKRSQLERQMNCDVLWCVLL... | 259 |
Q5JH82 | 5.6.2.2 | ACT_SITE 111; /note="O-(5'-phospho-DNA)-tyrosine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01385" | MPKRKIQRERPKEKFSYDPRKVLKMLDEHARRILEDIKAGKNPHFDIPMRGLSNVYFDEKSRLIKMGDKLSRRYFLNVAHARKFMQTLLIMAYVKRLVSEGKHASLREAYYANKHTIPGTRENTFEDQSESDPIIEDLERMFGVLREEMHITADRRGYIYGDIVIRDGEDEFNASRLGSGGWAVPGTVEHIQFPEINVDYALVVETAAMADRLIEEKFPKRENALIIATQGQASRGVRRLIHRLHYEEGLPIIVFTDGDPYGWYIYSTIKQGSINLAYLSDKLATPESKFVGMTMDDIKKYGLENVTEKLKGIPPNKKGG... | 222 |
B9IAC3 | 3.1.1.11 | ACT_SITE 425; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MYTMPKFFHANPRDKKTSFMAALSILLIIKILCLATFAEATTSKPLPSQFAKLSRSTTTPGAPSSTDTSPCKGTPYKAACQSLLLTLNTNNNADLPKTPKELFDYSVHFTSSQAHSAIDQLATTFLGQTYQEIDMTHLPGSGMRDCMELLDDTLDQLSNVINRKNDPTHTHNDVQTWLSAALTNQETCKESLLENVKKTHLEKFNVIDSMAKNLSQFISNSLALYVSSYGLPSTSPRGRKLLTDQSNIINDFPSWVSLSERKLLEASVGEIEAHAVVARDGSGTHTSIAEAIRQVAASLDGGGRNVIYIKAGTYKENLNI... | 125 |
Q5APN0 | 3.1.3.1 | ACT_SITE 124; /note="Phosphoserine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR601952-1" | MGLSNDQSPLLGGDSLTCWNKKQSGIKRNLSYLLNIITIGIIAYLCIFAKHSDNDDNTGLSLNPQKKKNIIMMVTDGMGPASLSAARSFRQFRDKLAINDILTLDKYLIGSSRTRSSSSLVTDSAAGATAFSCALKSYNGAIGVTPDKTPCGTVLEALKLQGYYTGLVVTTRITDATPAAFSSHVDYRFQEDLIAQHQLGEYPFGRAVDLILGGGRCHFLPTSEGGCRADNRNLIKEYSDKWQYVGDRVSFDQLQGGKNVSLPLLGLLANTDIPYDIERKDSEYPSLAEQVQVALTALSEATKDSEQGFFLLIEGSRIDH... | 141 |
P0CY20 | 3.1.3.7 | ACT_SITE 54; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:P32179"; ACT_SITE 146; /note="Proton acceptor"; /evidence="ECO:0000250|UniProtKB:P32179" | MSHTTHPYQKELEVATLAVKRASLLTKQLSDSIVQTARSGTLTKDDKSPVTIGDFASQAIINHAIKLNFPSDEIVGEEDSQELQENSSLADQVLSLIIKIQQETSVYNDVVGTLTDKNKVFQSIDYGNSQGGSKGRFWALDPIDGTKGFLRGDQFAVCLALIEDGKVVLGVIGCPNLSENIVSNEEHSGVVGGLYSAVKGVGSFYSELFKEGTEPLSQQKPIKMQNHTNPSQLKVVEGVEKGHSSHSTQAEIKAKLGFDPTTVAKQTVNLDSQVKYCVLASGQADIYLRLPVSDTYREKIWDHAAGNILIYESGGQVGDV... | 151 |
A0A8M6Z303 | 2.7.10.1 | ACT_SITE 769; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000666-1" | MPFTMTVGLITILSAVTAVYAMEETLMDTRTATAELGWTAYPSSGWEEVSGYDENLNTIRTYQVCNVFESNQNNWLLTTFIARRGAQRIYVEMRFTVRDCSSIPRVPGSCKETFNLYYYETDSVIATKGTAFWMEAPYLKVDTIAADESFSQVDFGGRLMKVNTEVRSFGPLSKNGFYLAFQDYGACMSLLSVRVFYKKCPSVVQNFAIFPETMTGAESTSLVIARGMCIPNSEEVDVPIKLYCNGDGDWMVPIGSCTCKAGFEPDNGNICRACPPGTFKASQGPGLCSQCPANSRSTSEAATICVCRNGYYRADGEQPD... | 97 |
I1HK82 | 3.1.1.11 | ACT_SITE 399; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MTVHYSAAVAVVLLLSLLSHSRSSSDAPPSTPVSPSAACNATTDPTFCRTVLPPHGTSDLYTYGRFSVAKSLASATKFVGLVDRYLARHRHLSRSAVGALQDCRLLAGLNVDFLSATGAALNDTTADDALLDTRGADDVQTLLSAILTNQETCIDGLQAASGAWSDRGDGGLASPIDNGTKLYSLSLSLFTRAWVKEEPAEKRHHGHKGHRTKPPSRRRGLFDARDEVMVRRMAIEGPQGTVAVNRAVTVDQGGAGNYTTVGDAVAAAPTNLNGSGGYYLIYVLTGVYEENVVVPKKMKYIMMIGEGIGQTVITGNRSVV... | 125 |
A0A3B6ATT5 | 1.11.1.7 | ACT_SITE 102; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAKLAAALTVLALLGCMAREGQADYGHPSPPPSTPCSPGHPSTPPSTATPPPPAPVPSPPASAELVVGYYQKTCHRAEDIVRETVRGANAGIMAGLVRLFFHDCFIRGCDASVLLDLADPSSATEKFGLPNLSLRGFEVIDAAKARIEKECGNVVSCADVLAFAGRDATYFLSNKKVYFEMPAGRYDGRVSLINETLIHLPPPFATVEQLKANFASKGLSADEMVTLSGAHTIGVSHCSSFDDDFSDRLNASTSDMDPKLMASLEKQCRSDTGNDNTVVQDIKTPNKLDNKYYKNVLSHEVLFASDAALLTADDTSAAVR... | 14 |
P00760 | 3.4.21.4 | ACT_SITE 63; /note="Charge relay system"; ACT_SITE 107; /note="Charge relay system"; ACT_SITE 200; /note="Charge relay system" | MKTFIFLALLGAAVAFPVDDDDKIVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIKQTIASN | 177 |
A0A2K1K5Q1 | 1.11.1.7 | ACT_SITE 70; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAAQRGRGGAFHLLLLLVSLMCVFHGTQGLRVGFYTNTCPNAETIVTQTVQNRFRRDKTITPALLRLFFHDCFVVGCDASLLINSTPKNSAEKDAGANLTVRGYDLIDAAKAAVEKACPGKVSCADIIALATRDVIALSGGPKFAMPTGRRDGRVSKASNVNLPGPSLSVADATRAFTAQGMTQNDMVTLLGAHTVGITHCSFFDDRLWNFQGTGRADPSMDANLVKQLKSVCPQRGVGLGRPVNLDQGTPNIVDKVFYSQLLAKKGILQLDQRLATDRATSQRTRTLAGPTSPFTKDFVAAIIKLGNVKVLEGTKGEIR... | 14 |
P39944 | 3.4.19.12 | ACT_SITE 455; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093"; ACT_SITE 761; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093" | MGSEQALSEVVESAKERFGRLRHLVQKFLDDDDVPQECLPLLQECAEIWSSYVDACQDITMQAPKEDANRLSKGFLRLNETAFLYYMIVYTLLEDTLPRLKEFSSNKDQNVRNLYGERIQLLHNDPNIERIRNVIENYPKFIQLQTIEPGKLSSMLHFHGDALLLIDVRPRSEFVRAHIKCKNIICIDPASFKDSFTDQQIESVSLITSPHSDITFFSNRDKFKFIILYTDTQLHNNFQQRQTRILAKILSQNSVIKPLSGTKILILENGFSNWVKLGGAYQSSVSETAHLTSSSSTPAFGSPQVPTGLFNQKSLSPNKD... | 175 |
A0A3B6AYX5 | 1.1.1.100 | ACT_SITE 229; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR611284-1" | MAAATAAAVASPAVTAPLPRAASSAARRGFVSFGGAAARPSALRSDRLRAAAAGFSSGVRTHVAAVEQAVVQDATELEAPVVVVTGASRGIGKAVALALGKAGCKVLVNYARSSKEAEAVSEEIEASGGQAITFGGDVSKEADVESMMKAAIDKWGTIDILVNNAGITRDTLLMRMKKSQWQDVIDLNLTGVFLCTQAATKVMMKKKKGRVINIASVVGLTGNAGQANYSAAKAGVIGFTKTVAREYASRNINVNAIAPGFIASDMTAELGEELEKRILSTIPLVSTNASFNFFTGRYGQPEEVAGLVEFLALNPAASYI... | 2 |
F1QYI8 | 3.1.3.48 | ACT_SITE 88; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR000941-50" | MIPVASGLYIGSVSDLKDAESLSAAGITHILTVDSEEASVTGFNTKFIRALDDESTDLLSRLDDCTSFISEALSTQADSKSAAVLVHCHVGQSRSAAVVTAYLMKTQHLTLQEAYSKLQNIKPDVKMNEEFLDQLALYELMDCKVDTTSPVYKQFRLKKITEKYPELQNVPKDVFAVDPAQTQNAEAVYRCRKCRRTLFRHSSILSHCVGSGASAFSHKKTRIVSSSAEDETQCTSYFIEPVQWMEQALLGVMDGQLLCPKCSSKLGSFNWYGEQCSCGRWVTPAFQMHKNRVDEIKHISISALK | 149 |
A7F794 | 3.1.3.16 | ACT_SITE 213; /note="Proton donor/acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR033096-1" | MSSTVPRPGAAKLGPRSGLEEWLAEAKQCHYLPEWAMKQLCEMVKECLMEESNIQPVATPVTICGDIHGQFYDLLELFRIAGGMPGETNVQAPTTVINTDALEPPTQITDPKLKKKIRSSDSGMESASGGDDDDDDEPRGRPRTAGGSNRSTSSGADSGININNNQVSGNGNQNFIFLGDFVDRGYFSLETFTLLMCLKATYPDKITLVRGNHESRQITQVYGFYEECQQKYGNASVWKSCCQVFDFLVLAAVVDGEVLCVHGGLSPEIRTVDQIRVVARAQEIPHEGAFCDLVWSDPEDVDTWAVSPRGAGWLFGDKVA... | 144 |
K3ZV64 | 1.11.1.7 | ACT_SITE 74; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MRMAPRGSNGSGGGTKLLLCLLLVACTGAAGQGLRVGFYQQSCPDAESIVRNVTWPAAAADPSLAAKLLRLFFHDCFPQGCDASVLLDGRGTEKAAGPNLSLGGLEVIDAAKAALERSCPGTVSCADAVALATRDAVSFQFGRLLWQVETGRRDSRFSDEADGTKLPNPEYVFPILRDSFARRGLGVADLVALSGAHTLGRTTCMFVSPRLYTFQGNGGVDPFIEPRYARELMGQCTSMASANRVVMDPGSEFAFDTSYYRAIKANRGVLLTDSVLTHDDEAARLVDEMQDLGKFLAAFAASIQKMGAMDVLTGSQGEIR... | 14 |
A0A3B6C239 | 1.11.1.7 | ACT_SITE 71; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MAASSELAILVACALLLAAACGGAPDDVPELEVGYYEETCPEAESIVRAAVSEAVAADAGVGAGLIRLLFHDCFVQGCDASVLLDPTASNPRPEKLGPPNFHSLRGFEAIDAAKAAVEEACPGTVSCADIVAFAARDASYLLSGYRVDFTMPAGRLDGRRSNASDTVPSLPPASASFTELVDNFARQGLDAEDMVVLSGAHSVGHARCSTFAAGRTAVDADADIDPSFARSLRRRCARAGNSTDGKEQDEPTVSQDTVTPTELDSQYYRNVLKRRVLLASDAALLETPEAARMVRDSASVGGRWEKKFAKAMVKMAGIGV... | 14 |
A0A1S4BD91 | 3.1.1.11 | ACT_SITE 402; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MYNLRRKTSLLLTLFALSAIVSLTFFTLSNNPKSSSKTVLTTTPHIHVHKNIQIAHSHCQDTRYPKLCVSTLSLIPDLAQKSISQIISSTINVTVAEVKASARNCTDIREDLPQLEPYEKRALEDCVQLLDNTIIELRTTLSDLNPKKPPSQNYNDLQTLLSAAMTNQATCLDGLARSKKNLRRYVQHNLHTIAHHVSNCLSMLKKMKKSSFSSSKSQEIYPEYGAVKNGFPKWLKKRDRALLQAPINETKIDLVVAKDGSGNFSTINEALSAAPNASTTRFVIYIKAGAYFEYIEVVRKKPMIMFLGDGIGKTLIKGNR... | 125 |
P15208 | 2.7.10.1 | ACT_SITE 1149; /note="Proton donor/acceptor"; /evidence="ECO:0000250" | MGFGRGCETTAVPLLVAVAALLVGTAGHLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNEECGDVCPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHKECLGNCSEPDDPTKCVACRNFYLDGQCVETCPPPYYHFQDWRCVNFSFCQDLHFKCRNSRKPGCHQYVIHNNKCIPECPSGYT... | 97 |
Q9RTM3 | 3.4.21.89 | ACT_SITE 38; /evidence="ECO:0000256|PIRSR:PIRSR600223-1"; ACT_SITE 103; /evidence="ECO:0000256|PIRSR:PIRSR600223-1" | MKRPAGVRRFWREWAGPVCWALLVTQFGASAVRVDGASMLPALRHGEWLALPKAEGWVHRLGLGEYQRGDVVVFKPPRSAAYEWTNVYRGVNLPWAYRPYLVKRVVGLPGDTVQVRAGTLYVNGQPVPEPRTLNYWAAFCHDTGSDLANTPPLKVPAAHYFVMGDNRSPGGSLDSRVFGPVPAWDVDSRAVASLWPLARQEEARPACDEQPQPEKRVQLSGPVQWNPRWGFGGR | 178 |
A0A0R4IF99 | 2.3.1.225 | ACT_SITE 183; /note="S-palmitoyl cysteine intermediate"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00067" | MRSWRWSVSRIMRLFLRWFRLCPRRGHRKRSRVRDLWNYGMVVLKSLYYNVQTNSDTVLDCMFEPIYWLVDNMTRWFGVVFVCLVMALTSSVVVIVYLCVLPIIFSSYPVYWILWHLCYGHWNLLMVVFHYYKATTTQPGFPPQEKTDIPTVTICKKCIVPKPARTHHCSICNRCILKMDHHCPWLNNCVGHFNHRYFFSFCLFMTMGCVYCSISAKDMFLDAYNAIESGRYKGGASQGEAVPGAGLIYISFQHQSSYQTPPPAFTHQERMVHKSLVYLWVLTSSVAVALGALTLWHAILITRGETSVERHINRKERRRL... | 57 |
A0A3B3HRX1 | 2.7.11.1 | ACT_SITE 140; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR038172-1" | MDIFPRPSGEIQRRNPQQDFELIQRVGSGTYGDVCKARNIQTGELAAVKIIKLEAGDDFSIIEQEIFMVKECKHHNIVAYFGSYLSRDKLWICMEYCSGGSLQDIYHVTGPLSEPQIAYVCRETLQGLAYLHSKGKMHRDIKGANILLTDNGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNGGYNQLCDIWAVGITSIELAELQPPMFDLHPMRALFLMSKSGFQPPKLKDKNSWSTAFHNFVKMSLTKSPKRRPTAEKLLTHVFVAQTGLSRRLAVDLLDSMNNPDNHRRPYSEADDDEFEPLSEVRH... | 99 |
I1HM81 | 1.11.1.7 | ACT_SITE 85; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MDSRGGVGDARRVSSVLNAMVLLAWACSFLGGADAQAQAQAQAKLDVGYYNGSCPDAEDLVTTIVHASIRMDPGNGPGLIRLFFHDCFVRGCDASVLLDDPTGNSTAEKDAPPNFPSLRGFGVIDRAKRVVERRCPGTVSCADILAFAARDASRIMGGVKYSVPAGRLDGRVSRSAEALNNLPPASSNITRLVSLFKSKNLTADDMVTLSGAHSIGRSHCSSFTSRLYPRIDATLNVTLGKALRAGKCPAATGRLDRVVQLDHVTPLMLDTQYYVNVGNHEVLFGSDQALTDRTDTARLVAAYAGNRKLWSRRFGEAMVQ... | 14 |
T1EHV9 | 3.2.1.143 | ACT_SITE 146; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 164; /evidence="ECO:0000256|PIRSR:PIRSR607724-1"; ACT_SITE 165; /evidence="ECO:0000256|PIRSR:PIRSR607724-1" | FEKILPGMIDLVLNSEFICTKPIPLLRRLKSASVSMSQHQASCLLANAFFCTFPSSNGHYFPEINFFGYFIYRRLSQSSKLHCIVNYFSRVVRQEAGDGVLTFTRQVLDDPPSIDFWKNSTSPLRDMLVSSEGLIEKDGEGMLQVDFANKYLGGGVLRTGCVQEEIRFITCPEAIVSCLLTECLLPNECLIIKGIETYSSFTGYAQSFRFHEDFVDCTPRDSWRRREKELVAIDALPFRKPADQFDENLILRELNKSYCGFMCTASNYLAPVATGKWGCGAFRGNPELKALIQLMSASECGRDMFFLTFGDANLAESLHH... | 159 |
Q9SCV8 | 3.2.1.23 | ACT_SITE 185; /note="Proton donor"; /evidence="ECO:0000255"; ACT_SITE 254; /note="Nucleophile"; /evidence="ECO:0000255" | MVLNFRDKSCIFLAILCCLSLSCIVKASVSYDRKAVIINGQRRILLSGSIHYPRSTPEMWPGLIQKAKEGGLDVIETYVFWNGHEPSPGQYYFGDRYDLVKFIKLVHQAGLYVNLRIGPYVCAEWNFGGFPVWLKFVPGMAFRTDNEPFKAAMKKFTEKIVWMMKAEKLFQTQGGPIILAQIENEYGPVEWEIGAPGKAYTKWVAQMALGLSTGVPWIMCKQEDAPGPIIDTCNGYYCEDFKPNSINKPKMWTENWTGWYTDFGGAVPYRPVEDIAYSVARFIQKGGSLVNYYMYHGGTNFDRTAGEFMASSYDYDAPLD... | 163 |
Q9XIP2 | 3.4.19.12 | ACT_SITE 224; /evidence="ECO:0000255"; ACT_SITE 227; /note="Nucleophile"; /evidence="ECO:0000250|UniProtKB:Q96G74"; ACT_SITE 332; /evidence="ECO:0000250|UniProtKB:Q96G74" | MTRILVQRGSSGSSSNSSRPSSSSSSSSGSETQINNNIPVPPVTIDEEITDEKQEEVTVVEKAECSDAKDVAVDSDEPADREDDEGLVVAENVHVQSEGIDCDSPVSGGSNSDSPPVPAPPPKPSSTVNPGSNRSVLGSFGALRIGPTRRAAGPRSLVSSRSSPTGSHPSSPRSHSENEGYNSSDEHMPCYVPSHPGSGLEREHQFEAEIRYSKGFEIRRMLEDGNCLFRAVADQVYGDSEAYDLARQMCMDYMEQERDHFSQFITEGFTSYLKRKRRDKVYGNNVEIQALAEMYNRPIHIYSYSTEPINIFQGNYSTDT... | 175 |
Q0E459 | 2.7.11.24 | ACT_SITE 139; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" | MEFFTEYGEASQYQIQEVVGKGSYGVVAAAVDTHTGERVAIKKINDVFEHVSDAIRILREIKVLRLLRHPDIVVIKHIMLPPTRREFRDIYVVFELMESDLHQVIEANHDLSPEHHRFFLYQLLCALKYIHSANVFHRDLKPKNILANSDCKLKICDFGLARVAFNDSPSTIFWTDYVATRWYRAPELCGSFFSKYTPAIDIWSIGCIFAEILTGRPLFPGRNVVHQLDLITDLLGTPSSETLSRIRNENARGYLTGMQRKHPIPFSHKFHNADPLALRLLERLLAFDPKDRPTAEEALADPYFRGISKLSREPSRLPVS... | 104 |
A0A8V0YEV0 | 2.7.10.2 | ACT_SITE 373; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037281-1" | MCWGGRGAICRVAGGFLGIPLLLQLQARVRSISSILYGEMDDWENNDFIQRLDFSSCGEEGEDRSINEEDTLSSSPIKHCDFQKWNSPLPATPHRKLSEIFLSRTKSWVSPTLKSSPGVSRTHGNAETPLHITWKKLQLCDTPHTPKSLLSKTAFPSPGAKVPPKGFRHLRFTPGADLDDSTQASLVNINPFTPESYRQMLFLPNGKRKAREIRNPDLRGQVKQELLTKRCPLKDSNMVSRYQKEFLELERIGVGEFGSVYKCIKRLDGCVYAIKRSKRPLAGSSDEQLALREVYAHAVLGHHPHVVRYYSAWAEDDHMI... | 98 |
C5WMG5 | 3.4.21.92 | ACT_SITE 177; /evidence="ECO:0000256|PROSITE-ProRule:PRU10085"; ACT_SITE 202; /evidence="ECO:0000256|PROSITE-ProRule:PRU10086" | MATATATSSSSLTTPLLRPNPNTNPAPRSLQLLRSRRCARAVTAAVAGGPVPYGAAPRRGIWSIRDDLVVPRSPYFPVESAAGQERGPSPMVMERFQSVVSQLFQHRIIRCGGPVEDDMANIIVAQLLYLDAIDPTKDIIMYVNSPGGSVTAGMAIFDTMKHIRPDVSTVCIGLAASMGAFLLSAGTKGKRYSLPNSRIMIHQPLGGAQGQETDLEIQANEMLHHKANLNGYLAYHTGQPLDKINVDTDRDYFMSAKEAKEYGLIDGVIMNPLKALQPLPASS | 179 |
Q17941 | 2.7.11.1 | ACT_SITE 316; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MSMTSLSTKSRRQEDVVIEGWLHKKGEHIRNWRPRYFMIFNDGALLGFRAKPKEGQPFPEPLNDFMIKDAATMLFEKPRPNMFMVRCLQWTTVIERTFYAESAEVRQRWIHAIESISKKYKGTNANPQEELMETNQQPKIDEDSEFAGAAHAIMGQPSSGHGDNCSIDFRASMISIADTSEAAKRDKITMEDFDFLKVLGKGTFGKVILCKEKRTQKLYAIKILKKDVIIAREEVAHTLTENRVLQRCKHPFLTELKYSFQEQHYLCFVMQFANGGELFTHVRKCGTFSEPRARFYGAEIVLALGYLHRCDIVYRDMKLE... | 99 |
A0A1U8FSJ6 | 3.1.1.11 | ACT_SITE 177; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MVMEWKEMGILTIMVMLWWSAGNCLKFDSTVAKDGSGKYKTIAAAINAAPKMRTKPYYIHVKRGIYYENVTIPYDKTNIALVGDGMGVTIISASKSSKRFPTPNTATLEVYGSGFIGMLMTIRNTAGAKNGQTAALTTAPFRGYASFFRCRFEGYQDTIFALDYAFFRGCHISGTIDFISGNGRAIFQKCSVEARKPIHGQEIRILAPGADNITSNPGIVLQNCKIYPEPGFNRSDGASFLGWPWKNQGKAVIMSSYINDFIDPKGWLSNPEVTNIYLAEYKNRGRGSNTRGRVKWSKVISGNEASKFTVRNFLQGEKWI... | 125 |
Q8RXC8 | 2.7.11.1 | ACT_SITE 267; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MNSASAHDLRLLEVDKEKQDPKSPRGALEACLTRCSISSASSSSDDPPPNREAIDNADADTDVQCKNHRASSNWGKFFKLWKRRSMKRLSSFPPLSGAAPPIIKQNKSADPNMNGMVLHDIYDFQSSLQNFSISDIEIATDNFSPENIIGRGGYADVYQGILPEGKLIAVKRLTKGTPDEQTAEFLSELGIIAHVDHPNTAKFIGCCIEGGMHLVFRLSPLGSLGSLLHGPSKYKLTWSRRYNVALGTADGLVYLHEGCQRRIIHRDIKADNILLTEDFQPQICDFGLAKWLPKQLTHHNVSKFEGTFGYFAPEYFMHGI... | 99 |
Q74A03 | 1.8.1.4 | ACT_SITE 437; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000350-2" | MQTFDVVVIGGGPGGMTAGMMLKQAGKSVAIIQENHDSFGGVCLNRGCMPTKSMLKAAKVYRDAQNSEKYGLDLSVNPVDLTRLRAVADADLNMLRHMVQGKLTDARIAVFRGKGSFLSEHELQICQADGSSEQIRGEKIIIATGSVPAELPCAPFDGHSILSSDQILKNTDLPHKLLIIGGGAIGCEFATLYNTFGSRVTLVEAMDSLLPREDKEAGKTLQSTFEQQGITVKTGAAIKSISVEAGTVHVHYDGSCATEEFDKVLVGIGRTANIAGLNLDAAGVATEQGAVKVNEMMQTTVPHIYALGDVIGGMTLAHAA... | 36 |
A9V0M9 | 3.1.3.48 | ACT_SITE 884; /note="Phosphocysteine intermediate"; /evidence="ECO:0000256|PIRSR:PIRSR608356-50" | MTAPSHTGLFLALCTGLLLLVQLPGHGPTLSAAACAAIDHCNSCPDEVHCLQCDTGRFLFDDTACVANCNAESTATVAYYNNVALRTCDLCHHTCARCVGPALDECTKCQPDAGFLLETTCVASCPISTFAQGTNDDASGRTCQDCAPGCAQCSNPTTCTACLPNWYIGLDNATCVQACPNGFGGQASSNTSLGGRCVPCDNATSCRTCTSSAPNSCIDCFFDKLAEDGFCVDACQVGFFNSSNTTCTRCGDTLAGCTECDAAGATCLVCDALHYLDQGTCHPLTTCSTWTYEGQAPTATTDRLCVPCPVCPEGSYLGTP... | 149 |
A0A2R6W8N4 | 3.5.1.98 | ACT_SITE 137; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR037913-1" | MPSKDRVSYFYDGDVGNVYYGPNHPMKPHRLCMTHSLVLAYGLHNKMEIYRPHKAYPVEMAQFHSEDYIEFLHRITPNMQEQYHQELLRYNMGEDCPVFDNLFEFCQIYAGGTIDAAHRLNNKLCDVAINWAGGLHHAKKCEASGFCYVNDLVLGILELLKYHARVLYIDIDVHHGDGVEEAFFLTDRVMTVSFHKFGDNFFPGTGDMKDIGDKDGKYYAINVPLKDGIDDASFTRLFKTIISKVVEFYQPGAIVLQCGADSLAGDRLGCFNLSIDGHSECVRYVKKLGLPLLVTGGGGYTKENVARCWTVETGVLVDTD... | 184 |
P34891 | 2.7.10.1 | ACT_SITE 319; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028" | MCLKMRYERIKYILLFSLMHLVYSNSTFESFTENPHISSQISNVLYMDQMFIIYILICILLILISVIVYLSKRYSQQMMQSSDNITNRRSNPEVRNKSNIYDLPPLLDVTSVNEETPIVKRPINERIENLEFDPRFEIDQAKLEISEDKLGSGFFGEVCYGLLSMRTSNTETDTLQKLSVAVKQSNDPTQENQEKMIEDETKLMCAIGRNPNILAIIGAVTANSGSARNLLIVEFVECGDLLKFLEEKKSIFKDELVYEKNGYLLPKSIRRKTYMFNENEDDVIEESLDSLCTSDLLSFSYQIAEGMEYLASIPCVHRDL... | 97 |
P20792 | 2.7.11.30 | ACT_SITE 423; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MRIRHVVFCLLALVYGAETSDDDLDERTNIFIRDKLIPALKLAEVTKVNFTRLHLCHCSREVGCNARTTGWVPGIEFLNETDRSFYENTCYTDGSCYQSARPSPEISHFGCMDEKSVTDETEFHDTAAKVCTNNTKDPHATVWICCDKGNFCANETIIHLAPGPQQSSTWLILTILALLTFIVLLGIAIFLTRKSWEAKFDWYIRFKPKPGDPLRETENNVPMVTMGDGAGSSVPEVAPIEQQGSTMSTSAGNSFPPGIMPNNMKDMLDVLEETSGSGMGPTTLHKLTIGGQIRLTGRVGSGRFGNVSRGDYRGEAVAVK... | 106 |
A9HYZ1 | 2.2.1.2 | ACT_SITE 126; /note="Schiff-base intermediate with substrate"; /evidence="ECO:0000255|HAMAP-Rule:MF_00492" | MSSQLEALRRHTTVVADTGDFEAMRALRPTDATTNPSLILKAVQKEAYRPLLQQVVRDHRGAPLAELTDRLLVAFGREILNIVPGRVSTEVDARLSFDTRATVERGRGLIALYEAAGIPRERVLIKTASTWEGIQAARLLQADGIRCNLTLLFSLPQAVACADAGVQLISPFVGRIYDWYKKAAGADWVEAERAGANDPGVQSVTEIYRYYKRHGITTEIMGASFRNKGQILALAGCDLLTISPELLAELDGAQGDVPVRLTRDDEAGEVPARRPADEVWFRTELNANAMATEKLAEGIRLFSADAIKLDALLGGAAGR | 52 |
E3KH04 | 2.3.1.225 | ACT_SITE 129; /note="S-palmitoyl cysteine intermediate"; /evidence="ECO:0000256|HAMAP-Rule:MF_03199" | MWSIDTGRLWIIGTTSLISFIAFTPQIFIIIPLFDHPSTNPDCLSLLIPFNILVGLLFINYYLCITTDPGRVPKEWDPIGLIESEEHDRAKILSLGQLRFCRACKVSKPPRAHHCRTCKRCVLKMDHHCPWVNNCVGHHNYGHFLRFLGFVDLACWYHIWMISKRVFGEFAYGPEPSKTEMIILVLNYVSCLPVILAVGVFSLYHLWAVLSNTTTIEGWEKEKARELRRKGRIQQFTYPFSIGIYRNLQVVLGPNPLLWWLPQRMSGDGLRYPTLATIDPLEQYLWPPRDLFTRRAPQLRRRQFEKEAFTYGEERLNPDL... | 57 |
C5XIT5 | 3.1.1.11 | ACT_SITE 400; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MAAAAFHTTTAALSAILALLLSLSLLVAVVRSDTAATPVTPSTACNETTDPNFCRTVLPSNGTSNLYTYGRFSVAKSLANANKFLGLVNRYLTRGGGGLSPGAVAALQDCQLLSGLNIDFLSSAGATLNTSGNSTLLDPQAEDVQTLLSAILTNQQTCADGLQVAAAAWSVRNGLAVPMVNSTKLYSVSLSLFTRAWVRSSAKANKSKSKPPRHGGGHGRGLFDATDDEMVRRMALDGVAAAVSVVGEVTVDPSGAGNYSTIGEAVAAAPTNLGGSTGYFVIRVPAGVYQENVVVPKNKKYVMMIGDGIGLSVVTGNRSV... | 125 |
Q9WYL2 | 1.8.1.4 | ACT_SITE 428; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000350-2" | MYDAVIIGGGPGGYVCAIKLAQLGKKVALVEKDALGGTCTNRGCIPTKAMLTVSHLMDEMKEKASKYGLKVSGVEYDVAAIMKHVQKSVMMSRKGIEYLLKKNGVEVFKGTAVVENKNTVVVQETGEKLEAKNLVLAHGSVPSVFSPFDIDGVWTSDDVFNLKEFPKSLVIVGGGVIGVEFATFFGSFGVDVTIVEIAEHILPYEDSDVAEEVKKALKRKGVKILEKTKISSLSKVDDGFEVALENGETLKAEKVLLAAGRKPNIPEDVKALGVKIEKGVVTDSRMRTNVENVYAIGDIRSGIMLAHVAMYEGIVAAKNI... | 36 |
Q04958 | 3.1.1.5 | ACT_SITE 1406; /note="Nucleophile"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"; ACT_SITE 1524; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01161" | MRSMNCTTNNTNNTGQNTKNSLGSSFNSSNYTSYRFQTCLTDQIISEAQTWSLSSLFNFSWVVSYFVMGASRMIFRYGWYLATLSLLRIPKWIFFKLHHVQFTLSFWLILFALAVIVFVTYTIMKERILSQYKRLTPEFLPLENTGKSGSSANINAASTQSANAPPAIGSSTTGASSIIDSKKHSLKDGNENETFLSSYLDQFLSAIKIFGYLEKPVFHDLTKNMKTQKMDEGEILLLDSTIGFAIVVEGTLQLYHEVDHSDKDHGDETDHSDTDGLDDQDRDEEDEEEDDDIDNYDTKSCSSNLIDEEDESVGYIHLKN... | 131 |
O64477 | 2.7.11.1 | ACT_SITE 619; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MVSFLTLTSFFFICFFIHGSSAVDTISGDFTLSGDQTIVSSDGTYEMGFFKPGSSSNFYIGMWYKQLSQTILWVANRDKAVSDKNSSVFKISNGNLILLDGNYQTPVWSTGLNSTSSVSALEAVLQDDGNLVLRTGGSSLSANVLWQSFDHPGDTWLPGVKIRLDKRTGKSQRLTSWKSLEDPSPGLFSLELDESTAYKILWNGSNEYWSSGPWNPQSRIFDSVPEMRLNYIYNFSFFSNTTDSYFTYSIYNQLNVSRFVMDVSGQIKQFTWLEGNKAWNLFWSQPRQQCQVYRYCGSFGICSDKSEPFCRCPQGFRPMS... | 99 |
Q39202 | 2.7.11.1 | ACT_SITE 657; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027" | MGSLSCSIIHLVLILQLQTFFVFSQNIRNGSVPVGESLTASESQQISSSWRSPSGDFAFGFRKIQPNDGFTLSIWFDKISDKTIVWHAQAVNTTTGLVPNGSKVTLTADGGLVIADPRGQELWRALSGGSVSRGRFTDDGNFVLFRDGSEDSDEVLWSSFENPTDTLLPNQNIEVGRNLSSRRTETSFKKGRFSLRLEDDGNLQLHSLNAETASESDIYSQYYESNTNDPNNPGIQLVFNQSGEIYVLQRNNSRFVVKDRDPDFSIAAPFYISTGFLLSTIIPKEARRIVGGCLLGLCRDNMCSPDDALGNMACGYNNIC... | 99 |
A0A9J7N454 | 3.1.1.4 | ACT_SITE 81; /evidence="ECO:0000256|PIRSR:PIRSR601211-1"; ACT_SITE 131; /evidence="ECO:0000256|PIRSR:PIRSR601211-1" | MASVRTLAIATVVCLGVVIVSSEDTERHERNRSRRNIFQTMMMLSCITEKSSFDYSDYGCYCGPGGQGKPVDILDQCCKVHDECYGTAEKNCFPLFEYIGVYEYECKDRKISCAIEDKTKLSCREFLCECDRKVNLCLTKNEKEYNSAYFNMDQAKCK | 130 |
A0A2K1IGA0 | 1.11.1.7 | ACT_SITE 71; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR600823-1" | MMGIWTAFKTLAAALLLVAMILKPVVEAQLQYGYYETLGCRGVENLVRTSVGLSFLTDPTASAAMLRLAFHDCQVGPGGCDGSIMVEGNGREMDAGGNFGVKRLDIINSVKADLERMCPMTVSCADIIAMVGRDAVAFSGGPEIQIPLGRKDADFSSASEADAKLPPSTSSVDTILSVFAPFGMSLAESVASLGAHTLGGGHCKNIQDRLRFNSPTAPTSLLYRTQLRAACVVNVFDIAILNNDASQFTFDNQYFKDIQNGRGLFTVDNLLSTDPRTAPIVSLYATNEAALFAAFQSAYVTLTSRAMTGTQGSVRSTCHL | 14 |
A0A2C9VTE0 | 3.1.1.11 | ACT_SITE 307; /evidence="ECO:0000256|PROSITE-ProRule:PRU10040" | MTTSSAMSLQLDGFETIQMAQTQILQIRKWVQSMGDELSRPLNHAGMAFSDCVKLYSESEFRLSQLLLNENETHDDTRMWLSGVLTNHRTCLNGLNEKGFDEIQLVTHNLTFWLNKALALQTQGSSIRKGVPRRPQDNQVGGTLTSWSPTTSKADFVVANDGSGTHRKINDVIAALKKFGSKRTRRVIIYVKAGVYNEKIEIDHSVKNVMLVGDGIDRTIITGNRNVADGDTTFGSATVGVSGDGFWARDITFENTAGPYKAQAVALRASSDFSVFYRCSFKGYQDTLYVLTMRQFYRDCRIYGTIDFIFGNAAVVFQNC... | 125 |
W5MZ16 | 2.7.10.1 | ACT_SITE 771; /note="Proton acceptor"; /evidence="ECO:0000256|PIRSR:PIRSR000615-1" | MLHLFLILGVLPCAAQDLKPPEIKPNVPEMVMNSGEILNLRCNGDNTVTWIVRLAKYKKYIKNNGTSSIFRARVQSSEFTGTYKCAYQNQPDLFSSVHVYVKDSSQLFITGSYNYHFLKKEGESVLLPCLLTDPSATDFSLRMENGSSVPRGMNYTADPKRGITIENLQPSFNADYVCRATKNGIEKVSSAFSINVIQKLRLPPYVFLETDEYIRIVGEKLEISCTTHNPNFNYNVTWKHSTRKALNVSEAAHSEGSRLAIRSILTIPKVSMSDTGNITCIGINEAGVNSSTTYLQVVDKPYIRLSTPQNTSLEVQEGQD... | 97 |
A0A7I4FS57 | 2.3.2.26 | ACT_SITE 1366; /note="Glycyl thioester intermediate"; /evidence="ECO:0000256|PROSITE-ProRule:PRU00104" | MIKGTMQHVSRGRQVSLRGASAKEQTRDELLDRVAQERAIRSLAKQAGASALVIQRIWRGRTVARKAAAQARADWDEQFLSRRVENQSPISADAISNEMLRPLFMILRHSSCFSLHQIRESSEDAGRLSTCFRLLLQSIQNPDVRYNYCDLSVGFPDKMSKWMHQARQLLRLACAALENESYGVREADQKGTDRNHMAQEGSNLAGLAMRVMVSLTDSSTWKCFGEPGQEVRKRKAELVVLRLLEWLASGSAGLFLAVRSYILANFPVPGIKDQLVRPRGKKDKFIITASIITVTLRPLLVLSAECDKDGQNDENPNDRK... | 65 |
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