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Accordingly, loss of striatal muscarinic M2/M4 / autoreceptors, a condition that causes an increase in endogenous acetylcholine (Zhang et al., 2002), impairs LTD but not LTP (Bonsi et al., 2008).
background
Results
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badee7f8b87dbf9d38775bebaad489d664fe0ef3
A couple of recent studies reported identifying large numbers of craniofacial enhancers; one study combined ChIP-seq for P300, H3K27ac, and H3K4me1 from neural crest cells derived from human embryonic stem cells (43), and the other study used ChIPseq for P300 from the whole face of E11.
result
RESULTS
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For example, it is well known that translation-invariant undecimated wavelets (Coifman and Donoho, 1995) are a dramatically more effective domain than the basic fully decimated orthogonal (or biorthogonal) wavelets for denoised a signal by shrinkage; the realization of 1 This work was partially…
background
1. INTRODUCTION
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2c7aaa61b15ea65b68055125e8bbd0189c464eb8
Our data, along with previously published findings (3, 9), suggest an additional mechanism by which the functional sarcolemmal pool of KATP channels is regulated.
result
DISCUSSION
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00d41fdcbbbd67e10a633f1bc263d78ce481299e
The length of yeast telomeres is regulated by the duplex telomeric DNA binding protein Rap1p (reviewed by Shore, 1994).
background
Introduction
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b6d6cb6e5486262882ba5442e989da0a460a09b3
HA monomer, consisting of two linked subunits; HA1 (~324 amino acids) and HA2 (~222 amino acids, (Webster et al., 1992), totally weighs about 60 kDa in the unglycosylated form (Sriwilaijaroen et al., 2012).
background
Results and Discussion
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765e5837332a6bfdf9e303d25b4313dc2db734fc
…demonstrated that blocking MST1/2 kinase activities with a newly identified compound, 4-((5,10-dimethyl-6-oxo-6,10-dihydro-5H-pyrimido [5,4-b]thieno[3,2-e][1,4]diazepin-2-l)amino)benzenesulfonamide (XMU-MP-1), has benefits for intestinal and liver repair and regeneration in mice (Fan et al., 2016).
background
DISCUSSION
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The merging is based on the increase in the weighted-bycounts entropy [1] and is stopped by a threshold indicating the minimum number of training samples required to estimate a weight distribution.
background
ACOUSTIC MODELLING
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Third, we used a meta-analysis technique to assemble the results of eligible studies, and the pooled results were presented in the format of quantitative data; whereas in the systematic review by Jiang et al, they only described the previous relevant studies and did not give a quantitative analysis for these studies.(1...
method
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68a821baf0d8ea6bfa004bf5e8030a236de5bf91
Ligation of SIRPα by CD47 is thought to promote the tyrosine phosphorylation of the cytoplasmic region of SIRPα.(20) We therefore propose that either cis or trans interaction of CD47 with SIRPα on cDCs promotes CD4 cDCs survival in secondary lymphoid organs by inducing the tyrosine phosphorylation of SIRPα.
background
f1e689177bcd9ee593b9968732bef00d685716b9
ac334326be0c94d7ede86535cdf4d99d4e5a8b79
The normalized image is not processed by the log-Gabor filters that are used by IrisBEE software [13] to create the “iris code” for recognition purpose and no geometrics features are used.
method
1 Introduction
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85c158797e0819f8f33c9832e3c1e392c2071415
Comparison of novel and annotated introns The GC content of both the novel and annotated introns sets was determined using the ‘geecee’ function within the European Molecular Biology Open Software Suite (EMBOSS) (Rice et al. 2000).
method
Methods
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092759f15088a18d41c700de4676ce868a31042c
In mammals, it has been shown in vitro that glucocorticoids act at the level of the pituitary to stimulate GH gene expression [57].
background
4. Discussion
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28ecd693a46bc87a826bf31de8ae4611175f3f24
Although the majority of studies examining val66met have found no association with AD (20, 25, 27-36), at least two studies have suggested higher frequencies of the val allele among patients with AD (19, 37).
background
72ad01f99b204cdff600384f7622adfc5ab05bce
88f90dffa3000897d2a3929623ea596ddbcf594f
Letters The Role of Ocular Perfusion Pressure in Glaucoma Cannot Be Studied With Multivariable Regression Analysis Applied to Surrogates Ocular perfusion pressure (OPP) is not easily directly measurable, and the difference between blood pressure and intraocular pressure (IOP) has been suggested as a simple surrogate of...
result
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d13f674ba3e4bac42a2753d9804d929eefb27b9c
Biological neurons in vivo show a substantial variability in the exact timing of action potentials to identical stimulus presentations (Calvin & Stevens, 1968; Softky & Koch, 1993; Shadlen & Newsome, 1998).
background
2 Methods
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a146d6514cb7db6eb511047abbc6983b04a077bb
Although not asked to patients themselves, our results indicated that physicians estimation was that patients’ perspective on NGS panels is likely to be highly positive (~66,5 %), coinciding with studies on pharmacogenomics/-genetics that did include patients in their study population [15, 16].
result
Discussion
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e0139cec4fff52560b75db1a9dccaee46b97c7a2
A number of factors can cause different time estimates from different molecular data (for detailed discussions, see Nikoh et al. 1997; Gu 1997).
background
63ce508d942d89bcf695e782b5d4ee85ade5c4e1
fc7bd558af7699381c4f41f2eb7d5326368d386a
Moreno et al. (1991); Rojas et al. (2001) and Moreira et al. (2008) have previously shown more isoamyl acetate production in coinoculation of S. cerevisiae with a non-Saccharomyces in wine fermentations.
background
Discussion
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c6e286f614eac1617e2db9f8f812a3ad91fca288
Two of themost important group of proteins involved in the cell cycle machinery are cyclins and cyclin-dependent kinases (CDKs) (Murray, 2004; Chulu and Liu, 2009).
background
Introduction
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The rationale for using hRPE cells was based on their ability to secrete L-dopa from tyrosine, catalyzed by the enzyme tyrosinase, as part of their eumelanin synthesis pathway (Ito and Wakamatsu 2008).
background
Introduction
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In contrast to the results here, Talukdar and Germida (1993) found that AMF colonization was different between lentil and wheat, and Scheublin et al. (2004) found that legumes were colonized by distinctly different AMF communities than nonlegume host plants.
result
Discussion
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None
Ozbag et al., found the prevalence of MBs to be 60 in 2002 (Ozbag et al. 2002) and 63 % in 2004 (Ozbag and Kervancioglu 2004) in sheep hearts.
background
Discussion
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6186e70a6bc014d7d5b82a4649574ef25e7b7ec0
The studies on VA are conducted for several languages and actual datasets are acquired for different languages including English [12, 13], German [14], French [15], Spanish [16] and Chinese [17–19].
background
1 Introduction
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4448616a83a88c54e1ffddf0390716630f9a4b70
…implicated the MEK/ERK signalling pathway in IFN-γ-stimulated iNOS expression; thus, exposure of microglial/ macrophage cells to this cytokine in the presence of MEK or ERK inhibitors inhibited the effect of IFN-γ (Blanchette et al., 2003; Han et al., 2003; Park et al., 2005; Shen et al., 2005).
method
4. Discussion
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d8d8ff0e4bb34d812807de4a5f7ce5dac7ea58f6
Moreover, the publications suggest that the approach makes it possible to foster a ‘shared responsibility between students and instructors’ (McLaughlin et al., 2014, p. 242), and overall, optimising classroom time is often specifically emphasised (Gannod et al., 2008; Mason et al., 2013; McLaughlin…
background
Results
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12a23d19543e73b5808b35f1ff2d00faba633bb6
Six studies [7, 15, 20, 24, 26, 27] were prospective, and two studies [18, 23] were randomized controlled studies.
background
Discussion
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a06e319feb1f855fd094d448cb600df56dcfb459
phi is a meta-program interpreted in [112, 24] as a second-order predicate which applies to the predicate p.
background
3 Related Work
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The results of this study indicate that the accumulation potential of feathers are in accordance with Skoric et al. (2012) and Misztal-Szkudlinska et al. (2012).
result
Discussion
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51ee5ac8744425724d7061adf9cc6eee37040134
Another on-demand algorithm that considers several Markov models is ActiveLeZi [Gopalratnam and Cook, 2007].
background
ActiveLeZi
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Zung Self-Rating Anxiety Scale (SAS) (6) was used to assess the degree of anxiety in pregnant women.
method
Methods
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5cb6131670ddcb14e088e6f4367fbbec0f636063
The Western immunoblotting procedure was used to localize and quantify Ca2 -ATPase, PLN, CaM kinase II, and calsequestrin in SR membrane vesicles and cardiac muscle homogenates according to the procedure described by Xu and Narayanan (59).
method
METHODS
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As stated by Spyropoulos (2000), a hospital infrastructure is composed of: (a) Human resources: physicians, nurses, administrative personal, technicians for equipment maintenance, etc. (b) Intensive therapy units, with an expensive infrastructure. ll rights reserved. ta Filho).
background
1. Introduction
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Indeed, mammalian nuclear receptors such as PPAR-a and PPAR-c are activated by fatty acids or their derivatives [26,27] and structural analysis of the ligand binding domain of HNF4a revealed long chain fatty acids bound in the ligand binding pocket [35,36].
background
Discussion
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e4b356c8b6ea3e0ea05a9243093e67f23737f63c
We retrospectively compared 2 methods that have been proposed to screen for IA [1, 2].
result
John M. Howell,1 Thom A. Mayer,1 Dan Hanfling,1 Allan Morrison,2 Glenn Druckenbrod,1 Cecele Murphy,1 Robert Cates,1 and Denis Pauze1
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Mammals, birds and reptiles have six MBDs; nematodes and insects contain four MBDs, whereas bacteria or lower eukaryotes (e.g. yeast) contain only one or two MBDs (Yu et al. 2017a).
background
Introduction
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641a2907c5e94d88c60daed34f72b724719cca55
The implied translational impairment of Scp160p target mRNAs in Scp160p-deficient cells is consistent with their slow-growth phenotype, especially when grown on media supplemented with translation elongation inhibitors (11,12).
background
RESULTS
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650a68920d6f007cd6d6de8a695fae07e7a8260f
Despite these limitations, AFM has turned out to be very useful in practice, for example in helping to refine KC models in given task domains [1,18,19,23], as we do in the current paper.
method
2 DATA-DRIVEN KC MODEL REFINEMENT USING THE ADDITIVE FACTORS MODEL
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, 2001) have been conducted since the establishment of highly active antiretroviral therapy (HAART) as the standard of care, with six additional studies (Baigis et al., 2002; Lox et al., 1996; MacArthur et al., 1993; Perna et al., 1999; Stringer, Berezovskaya, O’Brien, Beck, & Casaburi, 1998; Terry et al., 2006) includ...
background
Introduction
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In five consecutive sections, five measurements of GCL width were performed at 25 μm intervals (Haas et al., 2002; Houser, 1990) using AxioVision software (Carl Zeiss AG, Oberkochen, Germany).
method
Tissue preparation
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13d455598df90628864bca0122480b04a8879ac6
Several routing schemes as surveyed in [16] adopt the planar graph [24] derived from the unit disk graph (UDG) as their network topologies, such as GPSR [3], GFG [17], Compass Routing II [18], AFR [19], GOAFR [20] GOAFR+ [21], GOAFR++ [16], and GPVFR [22].
background
1 INTRODUCTION
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9ef0163c8ac0567e31f2ef4c9774373a350d0a2f
b-catenin normally associates with E-cadherin and with a-catenin and thereby participates in the regulation of cell-to-cell adhesion (Vleminckx and Kemler 1999; Miyoshi and Takai 2005).
background
Results
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48853d71ecf88b9341e448e130d36562470a1ae4
, 1983), along with downstream substrates, including NMDA receptors (NMDA-Rs) and AMPA-receptors (AMPA-Rs) (Yoshimura et al., 2000).
background
Introduction
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a29356d8937b8fe6e619c62c83bc51692c069dac
The Delphi method is an iterative, anonymous, data-driven survey method that facilitates expert-group consensus building.(22) The four defining characteristics of the Delphi method were upheld throughout the process: anonymity, iteration, controlled feedback, and statistical group response.
method
METHODS
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1efdd53a1965c2fbf9f5e2d26c239e85b0e7b1ba
These results are consistent with those of Liong and Shah, who reported that decreased fecal Escherichia coli counts result from probiotic feeding in rats (46).
result
DISCUSSION
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615e5987e27bb06ddaabf1aa5e9b8ccba70a4d87
…used in the present study has been proven to be suitable for the extraction of resveratrol from several transgenic plants (Szankowski et al., 2003; Zhu et al., 2004; Rühmann et al., 2006), resveratrol has not been found in methanol or acetone extracts of strawberry (Aharoni et al., 2002;…
background
Results and discussion
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described the prevalence of ASD in England as 4/10 000 for children aged 8–10 years (Lotter 1966).
background
Introduction
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55ff17eba1d9e452dfc60f0a6792ed24d2dcac1a
The duration of phase I was estimated from the averaged response profile, as the time at which there was a marked inflection point in the _ VO2, _ V CO2 and _ V E response and change in end tidal oxygen, end tidal carbon dioxide and R from baseline values (Whipp et al. 1982).
method
Methods
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d758571cc91a869dda07cd4b0b250f4815052a2d
In the past, emails, e-consultations, and requests for medical advice via the Internet have been manually analyzed using quantitative or qualitative methods [1-6].
method
Introduction
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dc029e23eed2ea6220d8e1f75dac4f9a741a50e0
It has also been documented that children and adolescents with epilepsy experience more emotional and behavioural problems than healthy controls and others with chronic conditions [9-26].
background
Introduction
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Other investigators using different experimental models, animals, and anesthetic agents experienced similar difficulty in stabilizing the circulatory volume when a crystalloid solution, saline, or Ringer solution was used to replace the blood lost (8, 12, 40, 41, 44, 55).
method
METHODS
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49fecaa4b95ef6c572d1233422dc4d5f97309b4b
In the subsequent studies, Yoshida et al. (2004b) and Ishii et al. (2004) confirmed the reversibility of 2,6-dihydroxybenzoate decarboxylase of Rhizobium sp. strain MTP-10005 and R.radiobacter WU-0108, respectively.
result
Discussion
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We used the HB cell lines HUH6 (Japanese Collection of Research Bioresources, JCRB, Osaka, Japan), HepT1 [41], HepT3 [7], and HepG2 [42], as well as the hepatocellular carcinoma (HCC) cell line HUH7 (JCRB).
method
Methods
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21a9a19b1e36448eed19a7b9dc291aefbde2f4db
…of a subpopulation of DA neurons which locate in the laterodorsal ventral tegmental area (VTA) (also referred to as medial and central VTA) (Valenti et al., 2012; Lammel et al., 2012), whereas short-term stress or other different chronic stressors (e.g., repeated intermittent stress)…
background
4. Discussion
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(2007) focus on slow EEG oscillations observed during deeper levels of desflurane-induced general anesthesia and (Liley and Bojak, 2005) model the proconvulsive properties of several volatile anesthetic agents, most modeling efforts aim at understanding the dynamical mechanisms underlying bi-phasic responses (Bojak and...
background
Introduction
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In fact, a decrease of ROS production in AS-30D cells by the potent uncoupler CCCP, both in the presence and absence of arachidonic acid, was described in our previous publication (Dymkowska et al., 2006).
background
RESULTS
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cb101cdbe7aac08d64577ea4ec526d1663a9899d
Wine polyphenols can reduce the susceptibility of LDL to oxidation, counteracting a key mechanism of atherosclerosis [13].
background
Introduction
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dbd999566f751b28966b510531223aee501ac556
At these concentrations, protein expression of Cx-43 was reduced by 80% for up to 72 h (21), and protein expression of Tph1 was reduced by 90% for up to 72 h.
background
MATERIALS AND METHODS
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Gas-phase smoke contains similar concentrations of these gases but is free of particulates (6).
background
METHODS
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464aeede29bcafb2ef221755a921c319b8259a1e
For example, cocaine affects dopamine (DA), norepinephrine (NE), and serotonin (5-HT) reuptake, and the enhanced monoaminergic signals lead to addictive behaviors (Ritz et al. 1990; Ritz et al. 1987).
background
Introduction
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31b7c09781dc8dfaec5dfaa3fd7157693b06232c
Reformulated from a neurobiological perspective, supraliminal stimuli induce global broadcasting i.e., long distance reinforcement and reverberation loops (Baars, 2002; Dehaene & Naccache, 2001).
background
4. Discussion
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414ca9cc4a095f65ba7ec8fe00bb994b1ae81c14
[25] Indeed, the polyfunctionality index (1) presented here allows us to favour more polyfunctional T cells in a linearly (q = 1) or exponentially (q.
method
Results
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21973265bda3188c92e0dc926106cba99c676368
Assessing Risk of Bias Critical appraisal of the studies, based on the Cochrane Risk of Bias Tool (Higgins and Green 2009), involved assessing whether there was an adequate method of sequence generation, allocation concealment, blinding of assessors, satisfactory treatment of attrition, including…
method
Methods
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Whole cell patchclamp recordings were performed at 30°C as described previously (20, 32, 37, 42, 45).
method
METHODS
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…contrast to most anti-inflammatory cytokines IL-10 concentrations increases during endurance exercise in thermoneutral conditions (Nieman et al. 2012; Peake et al. 2005, 2008; Svendsen et al. 2014) and increases further when exercise is conducted in a hot laboratory environment (Peake et al. 2008).
background
Discussion
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7b4cc07c1ddd84cb09eb5edd2c1ce2b90cf2dc28
The reciprocal of k is the turnover time (1) or the time interval required for the biosynthesis of an amount of NE equal to that stored in the tissue.
background
METHODS
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fdc650b26cc9d9ae43b57a8fe65a1213cdb14e8c
Determining the factors leading to current patterns of biodiversity loss in humandegraded landscapes is thus important in order to assess the likely effectiveness of future conservation efforts (Jeanneret et al. 2003a; Little et al. 2013).
background
Introduction
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In men, two studies [36, 43], indicated that obesity was associated with lower CRC screening rates.
result
3. Results
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1fdfeb2b7c8b5245ab8b407bc1464561685b8c66
This may be partially explained by the fact that younger and healthier patients are often more likely to be initially selected for TJR [17].
background
4. Discussion
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481b91ee6d0a96360e816644543172a555b9af11
These methods have been used in identifying causal regulators in yeast (Friedman et al., 2000; Pe’er et al., 2001; Segal et al., 2003; Zhu et al., 2008; Bing and Hoeschele, 2005; Kulp and Jagalur, 2006) and causal mediators of disease in mice (Schadt et al., 2005).
method
1. INTRODUCTION
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baa1821883e2cb4fac0e47740c49eebc02574ca0
In this regard, TONSL is already known to participate in the repair of collapsed or stalled replication forks (Duro et al. 2010; O’Connell et al. 2010; O’Donnell et al. 2010; Piwko et al. 2010), which is also a known BRCA1 function (Pathania et al.
background
Results
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aac9fb0178847fc4e17a1acdd5d9662ff53b9c94
The Real-time PCR has many other wider applications in other areas of research, such as microbiology, biotechnology, diagnostics and molecular medicine (Nolan et al. 2006).
method
Discussion
dff972e602bf60a30b7320e6a15e17e5bfe0b33a
8f880cf23c0896a0f58592cc696fbc577df95513
PCR amplification of the ITS region and PS36 and P74-75 SSR markers (Cooke et al. 2000; Dorrance and Grünwald 2009; Schena et al. 2008).
background
Materials and methods
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0296f987ace5acfdd29f730b2477356cc85bca9a
Molecular markers and population genetic analyses have greatly facilitated our ability to assess previously unobtainable data on the ecological or evolutionary dynamics of metazoan animal parasites in natural populations (Criscione et al., 2005; de Meeûs et al., 2007a).
background
1. Introduction
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Four or more vessels involved by FTC has been proposed to have a worse prognosis[7,11-15].
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Discussion
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Vol. 17, No. 4, December, 2013 translocation of these enzymes to the plasma membrane and/or other membrane (Littler et al., 2006; CorbalánGarcía & Gómez-Fernández, 2010).
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RESULTS
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d See MacWhinney and Snow (1985). e Satterthwaite’s method used, due to unequal variances.
method
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8).(8,13) These results are consistent with the reported differences in IOP values between diurnal and nocturnal raptors, considering ostriches’ natural diurnal behavior.
result
DISCUSSION
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They initialize their orthogonal mapping using an adversarial training phase, much like Conneau et al. [2018], and solve the optimization problem with alternating minimization. Our approach differs from theirs: by bootstrapping on the solution of a smaller problem to initialize the mapping, we avoid the need for a neur...
method
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In support of this conclusion is the previous observation that the relative contribution of the nanosecond and microsecond processes to the HOOP mode decay was temperature-dependent (Dioumaev and Braiman, 1997a).
result
DISCUSSION
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For Bd, initial gene calls were predicted using a combination of FGENESH30, GENEID31, EST-based genes and manual annotation; this initial set (previously made available on the Broad Institute website at https://www.broadinstitute.org/annotation/ genome/batrachochytrium_dendrobatidis/MultiHome.html) was improved using 5...
method
Methods
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The remaining descriptive data were collected via observation during the field site characterization, and during previous experiments [19,20].
method
Methods
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culturally dominant processing style (holistic or analytic thinking) (Nisbett et al., 2001), thinking
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Role of Holistic Thinking
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By pooling the feedforward inputs, a small proportion of V2 cells (Figure 3) and a large proportion of V4 cells (Chen et al., 2014) in the superficial (output) layers start to signal the global contour.
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Multiple Processes in Contour Detection
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However, they do not approach even the lowest suggested thresholds for P-limitation at the oldest site as used in other tests of progressive P limitation (Wardle et al. 2004).
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Discussion
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We report results with both the [26] and [27] versions of the detector of [14] as the baseline object detector.
method
5 Experiments
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Similar results (i.e. that greater decreases observed in g than in Amax) have also been reported in other forest species (Monson & Grant, 1989; Green & Mitchell, 1992; Zhang & Marshall, 1994) and crop plants (Ismail & Hall, 1992).
result
Discussion
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None
Pre- and post-test1 both included measurements of the S-reflex, M-wave, and H-reflex, followed by an MVC. S-reflex testing was performed at 0 , as in the study by Avela et al. (1999).
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Methods
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Clinically, they usually present with unilateral nasal obstruction, but other symptoms have also been reported such as epistaxis, purulent rhinorrhoea, postnasal drip, snoring, obstructive sleep apnoea, dysphonia, and dysphagia [3, 12].
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Introduction
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In the context of the second application, it has been exemplifi ed in several studies that exact optimization can be very diffi cult for real-world instances ([18, 11, 13]).
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1 Introduction
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For each LOOCV training set, the entire model building process was repeated, including the gene selection process.
method
Methods
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However, the amounts of the other PCR cycle enzymes and of electron transport components also vary in parallel with the amount of RuBisCO (von Caemmerer and Farquhar 1981; Makino et al. 1983).
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To fulfil this goal we used (as described in detail in the next section) the Th.o.m.a.s (Bosco et al., 2009a; see also Castellino et al., 2011; Laghi et al. in press), a semi-structured interview for investigating various aspects of ToM, plus a classical ToM test (Strange Stories test, Happé et…
method
INTRODUCTION
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Previous SPM studies (Salmon et al., 2000; Sakamoto et al., 2002; Kemp et al., 2003) matched the severity of dementia between early onset and late onset groups with MMSE or ADAS-cog (Alzheimer’s Disease Assessment Scalecognitive subscale) scores that reflect only the cognitive aspects of dementia.
result
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5 Mice with GLUT1-haploinsufficiency exhibited impaired motor activity and coordination, microencephaly, and frequent seizures (51).
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However, this mechanism implies higher cost due to high usage of resources [2].
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1. INTRODUCTION
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The two baselines considered in our experiments are two representatives from parametric and non-parametric categories: 1) OU (Orstein-Uhlenbeck (Huang et al., 2016)): modeling the drift term using an Orstein-Uhlenbeck process (Gillespie, 1996), which is a stationary Gauss-Markov process with the…
method
6 EXPERIMENTS
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This is a similar idea to the concept of a course or career fitting an individual’s values and expectations (Richardson & Watt, 2005) and may be a useful framework for considering decisions to pursue teacher education despite negative comments and experiences.
method
Methodology
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In accordance with our results, several studies demonstrated increased serum levels of sTNF-αR1 in the patients with chronic liver disease (Jorge et al. 2004), liver cirrhosis (von Baehr et al.
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Discussion
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In addition, p16 overexpression has been associated with tumor progression and a poor prognosis in ovarian (51) and breast cancers (36).
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Discussion
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