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The network is based on at least two patterning mechanisms each capable of explaining patterning alone (Pesch and Hülskamp, 2009).
background
INTRODUCTION
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dbd74df0907c8cf0ca52b2f118c93172eda92726
Drawing from career literature, mentoring is deemed to occur if mentors take an active interest in advancing the salesperson ’ s career by providing developmental assistance ( Higgins and Kram, 2001 ).
method
Vicarious learning and serendipity
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bbade2b57660640784f516deb2323373abcda169
Our results are roughly in line with those of Fukaya et al. (2008) with regard to the cell morphologies.
result
Technical considerations
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9b191008e5ce88ef5fb79694fa7fb8d7ab10170b
Andes have been eroded by the Patagonian ice sheet and are much lower and narrower (Garzione et al. 2008; Hoorn et al. 2010; Lavina & Fauth 2011).
background
Introduction
2b80f65e936e58979de232164026543edb2a79e8
8f01119d68d6a980ec1608e905be6e4f58cb328a
The largest correlations between the depression ratings and perceived social support were found within the sub-scales of Friends and Family (Clara et al., 2003).
background
Measures
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47646b38ed7584a32f3fd429068daa85c85c8318
Moreover, the risk of developing melanoma is greater in males than in females over the age of 40, although the opposite effect is observed in patients under 40 years old (Lens and Dawes, 2004; Jemal et al., 2010).
background
1. Introduction
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bfa8970f6292b80844289788eb8cf87caf4b6b7e
The LC microstructure of each eye was automatically segmented using a previously described method with high reproducibility.(13,14) The diameter of LC pores and the thickness of LC beams were defined by the 3D local thickness (Fig.
method
METHODS
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48b935f1b0143798e88ff0d96c217238ec0640b6
Very young (8-10 weeks old) rats were used in this study because it has been shown that younger rats are more sensitive to dietary salt loading than older ones (Dahl et al., 1968; Obiefuna et al., 1991; Sofola et al, 2002).
method
Methods
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33f3c96fb4ec5bbfd120b044f2e6f96bb0a86016
This noise stems from pulsatile motion of large arteries in the direct vicinity of the brainstem as well as from the flow of cerebro-spinal fluid (CSF) (Harvey et al., 2008; Klose et al., 2000).
background
Introduction
2d1877117d20cdfad12bf6340630c0cb35c2800f
334f0e7cef2e623f23691badc4b08277f2fb89e0
…replication (Anand et al., 1995), with olomoucine, an inhibitor of cyclin-dependent kinase activity (Glab et al., 1994; Meijer, 1996) and by RNAi (Fire et al., 1998; Tabara et al., 1998; Tabara et al., 1999; Grishok et al., 2000; Klink and Wolniak, 2000; Klink and Wolniak, 2001), using dsRNA…
method
Chiawei W. Tsai and Stephen M. Wolniak*
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15aa036f9761495ca881a3f21b09ceab90821104
The high rate of cardiac and renal dysfunction in critically ill patients limited the discriminative role of BNP, and no BNP value was able to completely rule out the presence of concomitant cardiac dysfunction (7).
background
Results
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983dfc44a86d441fb7ae5ec3b39e919ff8832b76
The rate of OJ− # production during reactions in vitro was measured as the superoxide dismutase (SOD)-sensitive rate of cytochrome c reduction (Imlay & Fridovich, 1991) in a Beckman DU 650 spectrophotometer.
method
METHODS
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daacf90f408ed66bd50801e2f88c2d7548bae260
Moreover, variability in analgesic efficacy could be explained by inter-subject variations in plasma levels of parent drug and its active metabolite eventually affected also by co-medications [19], and therefore, dosage must be titrated for optimal effect and avoidance of toxicity after appropriate TDM.
background
Real samples
33ac67007f2d23789386afed338c0fbe0590cced
a56efe6b6090b0f2fcadc321ba5f20642cee4fe0
Approximately 10 days after the completion of the experiments at sea level an arterial blood sample was taken for other purposes [14].
background
Methods
e453f864c86844b24d259ed7e1ecaa04b95447a9
03de2f175c55e6498b16321f71168102bbcfb7e1
The proof obligations generated by HIPComp are discharged using off-the-shelf constraint solvers (Omega Calculator [14] and Mona [15]).
method
6 Experiments
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2b77da9be256c954c8eb18a2d6ab6f5715950233
The GITT model performs better than an empirical lag-time model [17], however, its predicted profiles tend to underestimate Cmax, which, if consistent, may suggest confounding systematic bias or invalid assumptions.
method
Discussion
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55899ffa1ca17fd8ba86a6298a245723ddb22038
The identified propionylation sites (Okanishi et al. 2014) were approximately as much as that of acetylation in T.
background
Introduction
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b0fe8d2727db77f58bc430fef29aba3308ecd3f2
Similar findings were reported in healthy Italian children between 5 and 19 yr of age (32).
result
2.409 0.048† 0.409 0.096† 4.547 0.335† 8.601 0.469† 10.535 0.501† 6.477 0.443† 15.170 0.913† 4.013 0.86
8a1dcd51cabbd95bf7212a42a8fc5bae5d6b65e1
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Therefore, in addition to the provision of care and support in an all-female environment, many authors argue that, to be effective, women-specific services must also adopt approaches to care that are substantially different than the traditional care provided in mixed-gender settings [62,65,68,69,78,79,83,84].
background
Results and discussion
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7b889faead3d086f66e10d2b2024f1a85419c7d0
The 3-step admission system in the Netherlands has been described in more detail in a previous study.[17]
method
Methods
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0b4bbdda783fd49f6ff7ea2195e272edb4864308
Our results are partially consistent with the findings of previous works (Mühi et al., 2014; Zheng et al., 2016).
result
4. DISCUSSION
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None
Five-microliter yeast cells were spotted onto the interaction selection media (synthetic complete agar-Leu-Trp-His-Ala with 1.5 mM 3-amino-1,2,4-aminotriazole) to score growth as an indicator of protein–protein interaction (Lee et al., 2007).
method
METHODS
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hGFAP-Cre [19] and MATH1-GFP [20] transgenic animals were kindly provided by Rob Wechsler-Reya at Duke University.
method
Methods
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ce1b27189411624333ed9d53e0465f7dd77ba74c
Evidence for the measurement properties of the I-QoL has been demonstrated by a number of studies [17, 18, 20]; this study represents the largest evaluation in a UK population.
method
Discussion
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45ee8db9be57b97522566b1d1f6d2433cc464b72
It is conceivable that low dose dipyridamole might increase coronary flow through collaterals (19,20).
background
DISCUSSION
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dceca323f32c4134933a46fc11dc9ef986d76ce5
The CFI estimates the relative fit of the target model in comparison with the baseline model where all variables in the model are uncorrelated (Bentler, 1990; Hu & Bentler, 1995).
background
Results
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47cc78b221c86bd36f54a85782d725d73b54d7c2
For our experimental evaluation, we used the binary test-datasets of Weber et al. [35] and Batenburg and Sijbers [4].
method
3 Experiments
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f0ba230d3e53da034c6ddfbf2b323333cf3ca7fd
, 2016): the Bidirectional Attention Flow model (BiDAF) (Seo et al., 2016) and DrQA (Chen et al.
method
3.2 Experiments
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Both the methods used in the present work were previously demonstrated to be sufficiently accurate for detecting physiological and pathological changes in serum hepcidin in healthy volunteers and in patients with various disorders of iron homeostasis.(22,7,34,35) Indeed, results with the two methods were essentially co...
result
Discussion
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We also evaluated the quality of each study based on the Methodological Evaluation of Observational Research (MORE)- Observational Studies of Incidence or Prevalence of Chronic Diseases developed by the Agency for Healthcare Research and Quality (AHRQ) [14].
method
Methods
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(Note: We are aware of the method [3] which is another variant of 2D FCN and achieved excellent performance on the neuron dataset.
method
3 Experiments
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Randomized controlled trials conducted in a range of surgical settings over the last 25 years have clearly demonstrated that enoxaparin is associated with lower rates of VTE than placebo or elastic compression, without compromising patient safety [5–9].
background
Introduction
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080eb17ef2b5277926596d3939dea49efe7e4bb5
Evaluating diverse predictions Where only a single ground truth answer exists, the k-best oracle [11, 23] is a suitable scheme for evaluating diverse predictions.
background
4. Experiments
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In-between methods can be subdivided into linear approximations [12,24] and quadratic interpolation methods [22,23,25–27] based on the degree of the polynomial approximation employed.
background
1. Introduction
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41a02766e691213fd4840ca2d296a5e4815e6127
bacterial species can drive major changes in the gut microbiota and, thus, influence the metabolic profile (Marcobal et al., 2013).
background
Discussion
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2f587ec3f121d1121885a4a62d2a4a82422c14be
Xu et al [42] observed TF occupancy across the blocus of proerythroblast derived from fetal liver and adult stem cells.
background
Results and Discussion
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f7d7c5e9c19c62783efe129f6c612bd8f31e6a88
The well-known tumor suppressor p53 is a transcriptional master regulator that regulates the expression of genes associated with a wide range of functions, including cell-cycle arrest, apoptosis, and senescence in response to genotoxic andnongenotoxic stresses that challenge cellular genomic integrity (1).
background
Introduction
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CBP adds to its input layer an extra node having an input of the sum of the squared input components [1, 2].
method
1. Introduction
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3bc42f4bd59de4df802f2d86c962508dc074893a
reported that low miR-99a expression in hepatocellular carcinoma (HCC) tissues was associated with worse prognosis in HCC patients [10].
background
Discussion
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d6eaf36357406cc26c09d36fc88d8974ba49807d
Between 1987 and 1998 the prevalence of FOBT screening increased slightly, while screening rates for endoscopies doubled in the US [35].
background
Discussion
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7b8de28d12a53d3fd54f31e8448a644eca401cf4
It should be noted that a WURS cut-off score of 46 or higher can discriminate individuals with a history of childhood attention-deficit/ hyperactivity disorder (Kafka & Prentky, 1998; Roy-Byrne et al., 1997; Ward et al., 1993; Wender, 1995).
background
Method
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d519805d656c84366927a0c1d17632dbf13f6f42
This would be in accordance with data showing that the PVN is important for dietary preference for carbohydrates and lesions to the PVN result in increased preference for high fat diets (Aravich and Sclafani, 1983; Leibowitz, 1988; Hoebel et al., 1989).
result
DISCUSSION
dad87de5dd8af1bc493309f6908e79c8ddc11f44
None
Nonetheless, marketed EGFR antibodies have limited potential for development as ADCs because their significant binding to normal tissue causes on-target toxicity (9).
background
Introduction
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78d7043d67cce757c03bd61f2f981a900682e42d
An interdisciplinary approach has been advocated for in a broad range of healthcare fields, including primary care [1, 2], developmental disability assessment [3], com-
background
Introduction
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eab6176788b00d2273c348bdda11b40c7bf6d4f7
In addition, G4 DNA could form at telomeres either at the 3’ single strand G-rich overhang (22) or by molecular crowding of duplex DNA (23).
background
INTRODUCTION
190ae6a9bfb716339b0c61eb1af5f1b71aa223d0
a45a26a55ac52c0996172f2b5403b53d1d1adce8
In Section 2, we present an experiment by Abeler et al. (2010) that analyzes the relative importance of two conflicting fairness principles—wage equality and horizontal equity. In particular, Abeler et al. study whether equal wages are considered fair and look at potentially detrimental consequences of equal wages on p...
background
1 Introduction
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0d10e553c0a46e7384b3c34dc45bb063843a8300
Our findings, in accordance with Smith et al. (2004), demonstrate a neuropsychological dissociation between endogenous and exogenous validity effects.
result
5. Discussion
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102ea1abffceb6df270d310a1f68e062a0d71df6
(2016) demonstrated that blocking MST1/2 kinase activities with a newly identified compound, 4-((5,10-dimethyl-6-oxo-6,10-dihydro-5H-pyrimido [5,4-b]thieno[3,2-e][1,4]diazepin-2-l)amino)benzenesulfonamide (XMU-MP-1), has benefits for intestinal and liver repair and regeneration in mice (Fan et al., 2016).
background
DISCUSSION
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f22ae74ea1dd405108e55c996175e77ff0e575e4
1996) and then to the effector enzyme, namely phospholipase C-b 2 (PLC-b 2) (Adler et al. 2000).
background
In vertebrates, the taste system provides information used in the regulation of food ingestion. In mammals, each cell groupwithin the taste buds expresses either the
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5b46f45bca7105d113a22a874ea6c3c36adbb3e4
Another approach to scaling the PK parameters was a theoretical approach that fixed the allometric exponent to its theoretical values [14].
background
Methods
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e752107ed9886fbe8a9ef3d32ef5eb3a6ca82930
Previous research using the WSAP suggests that interpretation biases based on reaction time measures may be different for socially anxious undergraduates than for individuals with SAD (Amir et al. 2012).
method
Discussion
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89634acca7f883bb26a15b1db301488353d8654d
LDL CHD There is strong evidence that genetic variants that increase LDL also proportionately increase risk of CHD (46).
background
ANALOGY BETWEEN MENDELIAN RANDOMIZATION AND RANDOMIZED CONTROLLED TRIALS
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This method was recently used to estimate cancer incidence in France and China [22, 25] and is frequently used by GLOBOCAN [26].
method
3.2. Variability in the Methods Used by Cancer Registries.
e940ac7a7b3fb1e85be1db58b1f2fbcaa97b1046
dd92e9eac218f1f65ebc81d13e65cd9528a2aece
Rats were killed after 2.5 min, which was the time found to produce significant AA release mediated by PLA2 activity after in vivo LTP induction (Clements et al., 1991).
method
Methods
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b3cea3864739a63446da0ce5977207b6491075aa
Geographical locales where gonorrhoea incidence was much higher than surrounding areas have been identified as possible ‘core’ populations (Rothenberg 1983; Bernstein et al. 2004).
background
1. INTRODUCTION
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990f0494d4f46e43bdb76415e8524ce591902792
…studies found similar results when comparing resisted sprint training with elastic bands (Myer, Ford, Brent, Divine, & Hewett, 2007), weighted-sled (Spinks et al., 2007; West et al., 2012), weighted-vest (Clark et al., 2010; Rey, Padron-Cabo, & Fernandez-Penedo, 2016) with unresisted training on…
result
Discussion
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e8970513e7b53c68f1d83ba9a4e674275956bf3f
BM3D BRIS- CPBD JNB LPC S3 BIQI Metri- Ours QUE[17] [19] [11] [14] [26] [18] cQ[30]
background
22969ef928fd23237655dcf226a8dc76a5b971b0
38de7a68dd401e3b89e62a48763d9aa92897b88c
Protein extraction, western blots and immunoprecipitations were performed as previously described (Pentimalli et al., 2008).
method
Immunoprecipitation and western blot
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ae68f41cc1cf623107fc3535caa245090003ba03
…(Trueman et al., 1996); two NADH-NR, NR1 and NR2 (Long et al., 1992); nitrite reductase, NiR (Lahners et al., 1988); glutamate dehydrogenase, GDH1 (Sakakibara et al., 1995); four cytosolic GS, gln1, gln2, gln3, and gln4, plastidic GS, gln5 (Sakakibara et al., 1992a); and asparagine synthetase…
background
Materials and methods
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354a8f1284db59d4419031f081c8f6075243be7e
During phase (1), it looks for hidden correlations among the attribute values and the class attribute in the training data set and generates them as ‘‘Class Association Rule’’ (CARs) in ‘‘If-Then’’ format (Thabtah et al., 2004).
background
3. Associative Classification data mining
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Many investigations have focused on the evaluation of genotoxicity of pesticides in occupational or environmental settings using different methods (2-12).
method
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39e0463d624ac5c69f542b40253d47df75b9282a
Post-mortem studies have shown that cholinergic markers depletion strongly correlates with symptoms severity in AD (Dournaud et al., 1995; Prohovnik et al., 2006). ing Laboratory (TNL), McGill alth University Institute, 6875 rdun), QC, Canada H4H 1R3.
background
Introduction
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It is likely to be responsible for generating the proton gradient in these organelles detected with MitoLight and Rhodamine 123 staining (Zierdt et al. 1988; Nasirudeen and Tan 2004) and MitoTracker (Hamblin et al. 2008; Stechmann et al. 2008).
background
Discussion
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This is closely related to skin pigmentation as melanin has been shown to have a protective function for UV-induced melanoma and Caucasian populations show low levels of melanogenesis (Lens and Dawes, 2004; Hu et al., 2008; Jemal et al., 2010).
background
1. Introduction
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Stimuli surfaces were irregular-shaped wooden boards manually placed on a metal slope-presentation device that allowed the experimenter to quickly and accurately set the wooden board to a predetermined angle (see Durgin, Li & Hajnal, 2010; Li and Durgin, 2009).
background
Methods
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9b0628d503edf994bdfd285d283c63df1222ceef
These results are consistent with several studies that have suggested that miR-199a-3p is a potential tumor suppressor (24-27).
result
Discussion
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cc94900a9a02e39285ac23e5342706d2cfdb2e62
The answer to this question is currently unknown, but experimental evidence so far suggests that non-motile mutants are at a severe disadvantage for establishing and maintaining interactions with these hosts (Black et al., 1988; Nachamkin et al., 1993; Wassenaar et al., 1993; Hendrixson and DiRita, 2004; Wösten et al.,...
background
Discussion
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f20116e13a37c246a4f4e3d3ff18e4137ea69aaf
The importance of these techniques has led to a recent and intensive effort to develop and understand mathematical models for use in analysis of cell proliferation data [6, 12].
background
1 Introduction
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093382c01716447b742aeaeb3417c0b491857716
A major drawback with NIFAS was that the applet only showed one simultaneous tree, but in order to analyze the evolution of different domains it is essential to compare their trees visually.
method
2 Implementation
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661be9d2576e1838adea4f1b8b90c7a54640e2ba
Intermediate-conductance calcium-activated potassium channels (IK) enhance glioma cell migration induced by chemokines such as CXCL12 (74).
background
Ion Channels Facilitate Malignant Cell Migration
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5ce3d1c8b9721ac66367973a5a9c33a5d78ae2c5
EOs have proven effective in plant protection against plant chewing and sucking insect pests, as well as flies that oviposit in fruit [4].
background
Introduction
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83ca3870bb0515187d6db4a2eb14651746597768
…gametophytes and sporophytes, we conducted a preliminary analysis with all Glomus sequences from Botrychium (Ophioglossaceae; Kovács et al. 2007; Winther and Friedman 2007), Lycopodiaceae (Winther and Friedman 2008) and Psilotum nudum (Psilotaceae; Winther and Friedman 2009) reported in…
method
Materials and methods
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Moreover, the damp effect introduced by the back-plate will cause acoustic impedance, and to decrease the sensitivity of microphones subsequently [8-9].
background
INTRODUCTION
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f38fce19253f496bfa3d6eb99831338c2275aec0
Recently, analyses of archived African desert dust samples collected between 1812 and 1838 by colleagues of Charles Darwin demonstrated concentrations of bacteria and fungi of 104e105 CFU g 1 (Gorbushina et al., 2007).
background
3. Results and discussion
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a6a4a7b82224739378273f1fdbfeaaefe92d506f
The Hill coefficient values (“n”) were also consistent to those of the E. coli expressed P450 3A37 (Rawal et al., 2010b).
result
Metabolism of AFB1 by control TLMs
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ced7e3c1f9c912dca5751664c86a7587b58b0854
(GC) [23], Seeded Region Growing (SRG) [24], Random Walker (RW) [18], Distance Regularized Level Set (DRLSE) [25], and Laplacian Coordinates (LAP) [26].
background
3.1 Experimental Setup
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1442780fa1dfc4df886bb2dc201f69ddaa23ac29
One of the main problems in distributed systems is the deadlock problem [15].
background
1. Introduction
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260b50bf2bbd82e8c80acc4c0ebc73ecbd0279af
Although we found manual dissection of BG01 was successful, we adapted this line to trypsin-passaging on feeders and on Matrigel to facilitate comparison with an independently-derived line, HUES-7 (Cowan et al., 2004).
result
Results
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The saccadic movement can be made by asking the client during the examination (Kuicken et al., 2001-2002; Parker et al., 2009).
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2. Mechanism of Action
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Symptoms of pain and tenderness have been common complaints in the majority of cases resulting from melorheostosis of the hand, and although there are many theories regarding the etiology of pain, the cause of pain associated with is not known [3].
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Discussion
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Since cryptographic systems on medical devices are susceptible to differential power analysis and fault analysis attacks [29–40], it is critical to analyze the security of Rainbow on hardware.
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1 Introduction
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To find novel genes in the FHV-1 genome ab initio, and as a second approach to verify the annotation, the sequence was submitted to GeneMarkS (Besemer et al., 2001).
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BAC cloning
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, 2015), plant nursery runoff (Huett et al., 2005), barnyardmanure (Hill et al.
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Introduction
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The degree of spermatogenic failure in these patients can vary with some producing enough sperm for intracytoplasmic sperm injection [13, 15].
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Discussion
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Previously, preeclampsia has been associated with intrauterine growth restriction, in the setting of dysfunctional placental vascular development and function (18).
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DISCUSSION
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Further studies are still needed to exclude other purines such as ATP and related nucleotides, due to their significant release from bladder urothelium [8,9], and since ATP in some species can inhibit or relax the bladder [33–35].
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Discussion
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development of solutions and improvements to real-world problems (Holmström et al., 2009).
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Methodology
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Feature vectors were classified with a linear Support Vector Machine, for which we used the LIBLINEAR SVM library [8].
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4.2 Implementation details
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sequence was obtained using the I-TASSER server, which has been developed to generate automated full-length tridimensional protein structural predictions [31-33].
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Methods
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Social support can also affect individuals’ emotional well-being, including depression, as well as any other experienced adversities (Clara et al., 2003; Hefner & Eisenberg, 2009; Zaleski et al., 1998).
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Environmental Factors
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One of our proposed protocol is based on gossip protocols for completely decentralized distributed applications, such as an environment of [19] and guarantees causal message ordering, which is somewhat similar to temporal message ordering [12], based on logical time not physical time.
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4. Related Works
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The physical basis of the particular postulated form of U in [31] remains to be elucidated.
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3.4. Desolvation barriers rationalize intrinsic enthalpic folding barriers
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In this study, the Brix model [12, 13], a linear two-compartment open model where in the peripheral compartment has negligible effects on the central compartment, was used because it did not need T10 mapping or arterial input function measurements.
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Methods
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These criteria were intentionally lenient to prevent discarding any viable results; in actuality, the real amplitudes of crustal plateau short-wavelength folds are likely on the order of 100 m [e.g., Ghent and Hansen, 1999].
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3. Method
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A and tiagabine in native preparations leads to significant prolongation of the postsynaptic response at GABAergic synapses (Dingledine & Korn, 1985; Roepstorff & Lambert, 1992, 1994; Thompson & Gähwiler, 1992; Isaacson, Solis & Nicoll, 1993; Draguhn & Heinemann, 1996; Engel et al., 1998; Rossi &…
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Discussion
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Life history traits are an appropriate and important focus for the study of the ecological and evolutionary importance of polyploidy because (1) life history traits are often main determinants of fitness (e.g., Levy and Feldman 2002; Otto 2007; Ramsey 2011), and (2), ploidy level has the potential to influence life his...
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Introduction
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FIS quantifies the deviation from HWE with negative values indicating an excess of heterozygotes, and positive values indicating an excess of homozygotes (see de Meeûs et al., 2007a for a thorough explanation).
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1. Introduction
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, 2010) but also genetic or epigenetic modifications, contributing to cellular senescence (Dahl et al., 2008; Bork et al., 2010).
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Copyright ⓒ 2012 by the Korean Society for Biochemistry and Molecular Biology
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…in bulk cytosolic Ca21 concentration, caused a significantly smaller activation of MAPK in comparison with that resulting from glutamate receptor stimulation, supports the hypothesis that MAPK requires high localized Ca 21 rises for its activation in neurons (Finkbeiner and Greenberg, 1996, 1997).
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DISCUSSION
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To determine if the missing protein coding genes (belonging to the last two groups) were actually present in the draft sequence but Data is shown for six sequencing technologies; omitted is Illumina PacBio for which there are currently only eight genome projects without any missing genes. doi:10.1371/journal.pone.00488...
method
Methods
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