Datasets:
vgainullin
/
xciting_data

Dataset card Data Studio Files
xet
 Community
1
paragraph_index
int64
sec
string
p_has_citation
int64
cites
string
citeids
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pmid
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cited_id
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sentences
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DISCUSSION
1
51
[ "B51", "B14" ]
17,439,962
pmid-9920940|pmid-10585471|pmid-14563842|pmid-10585471|pmid-14563842|pmid-15794655|pmid-11330999
The Mg2+-bound dNTP substrate is proposed to enter the active site first, and is initially positioned by the interaction of its phosphate moiety with the enzyme (51).
[ "51", "14" ]
166
11,100
1
false
The Mg2+-bound dNTP substrate is proposed to enter the active site first, and is initially positioned by the interaction of its phosphate moiety with the enzyme.
[ "51" ]
The Mg2+-bound dNTP substrate is proposed to enter the active site first, and is initially positioned by the interaction of its phosphate moiety with the enzyme.
true
true
true
true
true
1,776
7
DISCUSSION
1
51
[ "B51", "B14" ]
17,439,962
pmid-9920940|pmid-10585471|pmid-14563842|pmid-10585471|pmid-14563842|pmid-15794655|pmid-11330999
The Mg2+ ion coordinates Asp190 and 192.
[ "51", "14" ]
40
11,101
0
false
The Mg2+ ion coordinates Asp190 and 192.
[]
The Mg2+ ion coordinates Asp190 and 192.
true
true
true
true
true
1,776
7
DISCUSSION
1
51
[ "B51", "B14" ]
17,439,962
pmid-9920940|pmid-10585471|pmid-14563842|pmid-10585471|pmid-14563842|pmid-15794655|pmid-11330999
Upon binding of the Mg2+–dNTP, the polymerase is thought to assume a closed conformation.
[ "51", "14" ]
89
11,102
0
false
Upon binding of the Mg2+–dNTP, the polymerase is thought to assume a closed conformation.
[]
Upon binding of the Mg2+–dNTP, the polymerase is thought to assume a closed conformation.
true
true
true
true
true
1,776
7
DISCUSSION
1
51
[ "B51", "B14" ]
17,439,962
pmid-9920940|pmid-10585471|pmid-14563842|pmid-10585471|pmid-14563842|pmid-15794655|pmid-11330999
The catalytic Mg2+ then binds and coordinates both Asp256 and Asp192.
[ "51", "14" ]
69
11,103
0
false
The catalytic Mg2+ then binds and coordinates both Asp256 and Asp192.
[]
The catalytic Mg2+ then binds and coordinates both Asp256 and Asp192.
true
true
true
true
true
1,776
7
DISCUSSION
1
51
[ "B51", "B14" ]
17,439,962
pmid-9920940|pmid-10585471|pmid-14563842|pmid-10585471|pmid-14563842|pmid-15794655|pmid-11330999
It also coordinates with the 3′ OH of the primer strand.
[ "51", "14" ]
56
11,104
0
false
It also coordinates with the 3′ OH of the primer strand.
[]
It also coordinates with the 3′ OH of the primer strand.
true
true
true
true
true
1,776
7
DISCUSSION
1
14
[ "B51", "B14" ]
17,439,962
pmid-9920940|pmid-10585471|pmid-14563842|pmid-10585471|pmid-14563842|pmid-15794655|pmid-11330999
After binding of the catalytic Mg2+, phosphodiester bond formation is observed in crystals (14).
[ "51", "14" ]
96
11,105
1
false
After binding of the catalytic Mg2+, phosphodiester bond formation is observed in crystals.
[ "14" ]
After binding of the catalytic Mg2+, phosphodiester bond formation is observed in crystals.
true
true
true
true
true
1,776
7
DISCUSSION
1
51
[ "B51", "B14" ]
17,439,962
pmid-9920940|pmid-10585471|pmid-14563842|pmid-10585471|pmid-14563842|pmid-15794655|pmid-11330999
Asp256, which is part of a β strand, is just three amino acid residues away from loop II and could be affected by geometric strain or movements of the five residue loop variants.
[ "51", "14" ]
178
11,106
0
false
Asp256, which is part of a β strand, is just three amino acid residues away from loop II and could be affected by geometric strain or movements of the five residue loop variants.
[]
Asp256, which is part of a β strand, is just three amino acid residues away from loop II and could be affected by geometric strain or movements of the five residue loop variants.
true
true
true
true
true
1,776
7
DISCUSSION
1
51
[ "B51", "B14" ]
17,439,962
pmid-9920940|pmid-10585471|pmid-14563842|pmid-10585471|pmid-14563842|pmid-15794655|pmid-11330999
Thus, if a five-member loop assumes an aberrant structure or lacks proper dynamic movement, it could result in destabilization of Asp256.
[ "51", "14" ]
137
11,107
0
false
Thus, if a five-member loop assumes an aberrant structure or lacks proper dynamic movement, it could result in destabilization of Asp256.
[]
Thus, if a five-member loop assumes an aberrant structure or lacks proper dynamic movement, it could result in destabilization of Asp256.
true
true
true
true
true
1,776
7
DISCUSSION
1
51
[ "B51", "B14" ]
17,439,962
pmid-9920940|pmid-10585471|pmid-14563842|pmid-10585471|pmid-14563842|pmid-15794655|pmid-11330999
This could lead to slightly altered positioning of the 3′ terminus of the primer or the incoming dNTP and result in misincorporation.
[ "51", "14" ]
133
11,108
0
false
This could lead to slightly altered positioning of the 3′ terminus of the primer or the incoming dNTP and result in misincorporation.
[]
This could lead to slightly altered positioning of the 3′ terminus of the primer or the incoming dNTP and result in misincorporation.
true
true
true
true
true
1,776
8
DISCUSSION
1
5
[ "B5" ]
17,439,962
pmid-8538772
In our BER assay, all of the loop II variants were able to participate in the reaction that led to the finished ligation product, including loops consisting of 0–2 amino acid residues.
[ "5" ]
184
11,109
0
false
In our BER assay, all of the loop II variants were able to participate in the reaction that led to the finished ligation product, including loops consisting of 0–2 amino acid residues.
[]
In our BER assay, all of the loop II variants were able to participate in the reaction that led to the finished ligation product, including loops consisting of 0–2 amino acid residues.
true
true
true
true
true
1,777
8
DISCUSSION
1
5
[ "B5" ]
17,439,962
pmid-8538772
This suggests that pol β does not have to possess robust polymerase activity to participate in BER, and supports the idea that the dRP lyase activity of pol β is critical for repair (5).
[ "5" ]
186
11,110
1
false
This suggests that pol β does not have to possess robust polymerase activity to participate in BER, and supports the idea that the dRP lyase activity of pol β is critical for repair.
[ "5" ]
This suggests that pol β does not have to possess robust polymerase activity to participate in BER, and supports the idea that the dRP lyase activity of pol β is critical for repair.
true
true
true
true
true
1,777
8
DISCUSSION
1
5
[ "B5" ]
17,439,962
pmid-8538772
However, we have recently found that a pol β variant that possesses dRP lyase activity but no polymerase activity does not support BER in vitro (Lang et al., submitted for publication), suggesting that both the dRP lyase and polymerase activities of pol β are critical for repair.
[ "5" ]
280
11,111
0
false
However, we have recently found that a pol β variant that possesses dRP lyase activity but no polymerase activity does not support BER in vitro (Lang et al., submitted for publication), suggesting that both the dRP lyase and polymerase activities of pol β are critical for repair.
[]
However, we have recently found that a pol β variant that possesses dRP lyase activity but no polymerase activity does not support BER in vitro (Lang et al., submitted for publication), suggesting that both the dRP lyase and polymerase activities of pol β are critical for repair.
true
true
true
true
true
1,777
8
DISCUSSION
1
5
[ "B5" ]
17,439,962
pmid-8538772
The demonstration that even the Loopless variant of pol β participates in BER also suggests that loop II is unlikely to be important for interactions with other proteins that are important for BER.
[ "5" ]
197
11,112
0
false
The demonstration that even the Loopless variant of pol β participates in BER also suggests that loop II is unlikely to be important for interactions with other proteins that are important for BER.
[]
The demonstration that even the Loopless variant of pol β participates in BER also suggests that loop II is unlikely to be important for interactions with other proteins that are important for BER.
true
true
true
true
true
1,777
0
INTRODUCTION
1
1
[ "b1", "b2", "b3", "b4" ]
17,151,068
pmid-16339370|pmid-15608257|pmid-16381931|pmid-16381938
The Rat Genome Database (RGD, ) is the model organism database for the laboratory rat, Rattus norvegicus.
[ "1", "2", "3", "4" ]
105
11,113
0
false
The Rat Genome Database (RGD, ) is the model organism database for the laboratory rat, Rattus norvegicus.
[]
The Rat Genome Database (RGD, ) is the model organism database for the laboratory rat, Rattus norvegicus.
true
true
true
true
true
1,778
0
INTRODUCTION
1
1
[ "b1", "b2", "b3", "b4" ]
17,151,068
pmid-16339370|pmid-15608257|pmid-16381931|pmid-16381938
The primary goal of the database is to provide convenient access to high quality data about the genes and genome of the Rat and to support the goals of researchers using the rat as a genetic and genomic model [see (1) for a review of the impact of genomics in rat research].
[ "1", "2", "3", "4" ]
274
11,114
0
false
The primary goal of the database is to provide convenient access to high quality data about the genes and genome of the Rat and to support the goals of researchers using the rat as a genetic and genomic model.
[ "see (1) for a review of the impact of genomics in rat research" ]
The primary goal of the database is to provide convenient access to high quality data about the genes and genome of the Rat and to support the goals of researchers using the rat as a genetic and genomic model.
true
true
true
true
true
1,778
0
INTRODUCTION
1
1
[ "b1", "b2", "b3", "b4" ]
17,151,068
pmid-16339370|pmid-15608257|pmid-16381931|pmid-16381938
In pursuit of these goals we curate a variety of other relevant information such as mapping information (genetic maps, radiation hybrid maps and most recently the genome assembly), quantitative trait loci (regions of the rat genome believed to contain a gene or genes related to a particular phenotype or trait), rat str...
[ "1", "2", "3", "4" ]
432
11,115
0
false
In pursuit of these goals we curate a variety of other relevant information such as mapping information (genetic maps, radiation hybrid maps and most recently the genome assembly), quantitative trait loci (regions of the rat genome believed to contain a gene or genes related to a particular phenotype or trait), rat str...
[]
In pursuit of these goals we curate a variety of other relevant information such as mapping information (genetic maps, radiation hybrid maps and most recently the genome assembly), quantitative trait loci (regions of the rat genome believed to contain a gene or genes related to a particular phenotype or trait), rat str...
true
true
true
true
true
1,778
0
INTRODUCTION
1
1
[ "b1", "b2", "b3", "b4" ]
17,151,068
pmid-16339370|pmid-15608257|pmid-16381931|pmid-16381938
This data is acquired from a variety of sources: the literature, other scientific databases and through bioinformatic analyses performed locally.
[ "1", "2", "3", "4" ]
145
11,116
0
false
This data is acquired from a variety of sources: the literature, other scientific databases and through bioinformatic analyses performed locally.
[]
This data is acquired from a variety of sources: the literature, other scientific databases and through bioinformatic analyses performed locally.
true
true
true
true
true
1,778
0
INTRODUCTION
1
1
[ "b1", "b2", "b3", "b4" ]
17,151,068
pmid-16339370|pmid-15608257|pmid-16381931|pmid-16381938
The public website provides convenient access to this data through search tools, web page reports and more specialized bioinformatics tools that can be used to do novel analyses directly online.
[ "1", "2", "3", "4" ]
194
11,117
0
false
The public website provides convenient access to this data through search tools, web page reports and more specialized bioinformatics tools that can be used to do novel analyses directly online.
[]
The public website provides convenient access to this data through search tools, web page reports and more specialized bioinformatics tools that can be used to do novel analyses directly online.
true
true
true
true
true
1,778
0
INTRODUCTION
1
2
[ "b1", "b2", "b3", "b4" ]
17,151,068
pmid-16339370|pmid-15608257|pmid-16381931|pmid-16381938
Data curated at RGD is also available through other global genomics resources such as NCBI/Entrez Genes (2) and on the Ensembl (3) and UCSC genome browsers (4).
[ "1", "2", "3", "4" ]
160
11,118
1
false
Data curated at RGD is also available through other global genomics resources such as NCBI/Entrez Genes and on the Ensembl and UCSC genome browsers.
[ "2", "3", "4" ]
Data curated at RGD is also available through other global genomics resources such as NCBI/Entrez Genes and on the Ensembl and UCSC genome browsers.
true
true
true
true
true
1,778
0
INTRODUCTION
1
1
[ "b1", "b2", "b3", "b4" ]
17,151,068
pmid-16339370|pmid-15608257|pmid-16381931|pmid-16381938
In addition, our data is freely available as FTP files to enable anyone to use it in their research or analysis.
[ "1", "2", "3", "4" ]
112
11,119
0
false
In addition, our data is freely available as FTP files to enable anyone to use it in their research or analysis.
[]
In addition, our data is freely available as FTP files to enable anyone to use it in their research or analysis.
true
true
true
true
true
1,778
1
INTRODUCTION
1
5
[ "b5", "b6", "b7", "b6" ]
17,151,068
pmid-10802651|pmid-16564748|pmid-16899495|pmid-16564748
A resource like RGD evolves in parallel with its community and for a model organism database, this community includes the researchers using that model organism and also the broader genomics and bioinformatics communities wishing to access and use this data.
[ "5", "6", "7", "6" ]
257
11,120
0
false
A resource like RGD evolves in parallel with its community and for a model organism database, this community includes the researchers using that model organism and also the broader genomics and bioinformatics communities wishing to access and use this data.
[]
A resource like RGD evolves in parallel with its community and for a model organism database, this community includes the researchers using that model organism and also the broader genomics and bioinformatics communities wishing to access and use this data.
true
true
true
true
true
1,779
1
INTRODUCTION
1
5
[ "b5", "b6", "b7", "b6" ]
17,151,068
pmid-10802651|pmid-16564748|pmid-16899495|pmid-16564748
One of the most significant trends in recent years that has greatly influenced the database has been the use of biological ontologies, of which the Gene Ontology (5) is perhaps the most well known.
[ "5", "6", "7", "6" ]
197
11,121
1
false
One of the most significant trends in recent years that has greatly influenced the database has been the use of biological ontologies, of which the Gene Ontology is perhaps the most well known.
[ "5" ]
One of the most significant trends in recent years that has greatly influenced the database has been the use of biological ontologies, of which the Gene Ontology is perhaps the most well known.
true
true
true
true
true
1,779
1
INTRODUCTION
1
5
[ "b5", "b6", "b7", "b6" ]
17,151,068
pmid-10802651|pmid-16564748|pmid-16899495|pmid-16564748
By providing a set of standardized terms, definitions and relationships between the terms, ontologies are very convenient for researchers as a way to consistently annotate and categorize data.
[ "5", "6", "7", "6" ]
192
11,122
0
false
By providing a set of standardized terms, definitions and relationships between the terms, ontologies are very convenient for researchers as a way to consistently annotate and categorize data.
[]
By providing a set of standardized terms, definitions and relationships between the terms, ontologies are very convenient for researchers as a way to consistently annotate and categorize data.
true
true
true
true
true
1,779
1
INTRODUCTION
1
5
[ "b5", "b6", "b7", "b6" ]
17,151,068
pmid-10802651|pmid-16564748|pmid-16899495|pmid-16564748
For the bioinformatics community they are emerging as a way to standardize data representations, enabling cross-organism data mining and analysis and have opened up avenues for novel data representation and integration (6,7).
[ "5", "6", "7", "6" ]
225
11,123
0
false
For the bioinformatics community they are emerging as a way to standardize data representations, enabling cross-organism data mining and analysis and have opened up avenues for novel data representation and integration.
[ "6,7" ]
For the bioinformatics community they are emerging as a way to standardize data representations, enabling cross-organism data mining and analysis and have opened up avenues for novel data representation and integration.
true
true
true
true
true
1,779
1
INTRODUCTION
1
6
[ "b5", "b6", "b7", "b6" ]
17,151,068
pmid-10802651|pmid-16564748|pmid-16899495|pmid-16564748
Another significant trend facing anyone using online resources and one that is particularly acute for modern biologists is the massive increase in information available (6).
[ "5", "6", "7", "6" ]
173
11,124
1
false
Another significant trend facing anyone using online resources and one that is particularly acute for modern biologists is the massive increase in information available.
[ "6" ]
Another significant trend facing anyone using online resources and one that is particularly acute for modern biologists is the massive increase in information available.
true
true
true
true
true
1,779
1
INTRODUCTION
1
5
[ "b5", "b6", "b7", "b6" ]
17,151,068
pmid-10802651|pmid-16564748|pmid-16899495|pmid-16564748
The problem ranges from not finding enough data to finding too much and being unable to efficiently comprehend what is available.
[ "5", "6", "7", "6" ]
129
11,125
0
false
The problem ranges from not finding enough data to finding too much and being unable to efficiently comprehend what is available.
[]
The problem ranges from not finding enough data to finding too much and being unable to efficiently comprehend what is available.
true
true
true
true
true
1,779
1
INTRODUCTION
1
5
[ "b5", "b6", "b7", "b6" ]
17,151,068
pmid-10802651|pmid-16564748|pmid-16899495|pmid-16564748
Driven by the needs of our community we have been exploring ways to utilize the descriptive power of our ontology annotations combined with innovative visualization tools and web designs to begin to address this problem.
[ "5", "6", "7", "6" ]
220
11,126
0
false
Driven by the needs of our community we have been exploring ways to utilize the descriptive power of our ontology annotations combined with innovative visualization tools and web designs to begin to address this problem.
[]
Driven by the needs of our community we have been exploring ways to utilize the descriptive power of our ontology annotations combined with innovative visualization tools and web designs to begin to address this problem.
true
true
true
true
true
1,779
0
INTRODUCTION
1
1
[ "B1", "B2", "B3", "B4 B5 B6", "B7", "B8", "B9", "B10", "B11", "B7", "B9" ]
17,329,374
NA|pmid-12102553|pmid-3317449|pmid-11525387|pmid-12630848|NA|pmid-11098823|pmid-570092|pmid-2431763|pmid-10561728|pmid-15294448|pmid-11098823|pmid-2431763|pmid-2431763|pmid-6538808|pmid-1749377
cis-Diamminedichloroplatinum(II) (cisplatin) (Figure 1A) has been widely used in chemotherapy for almost 30 years.
[ "1", "2", "3", "4–6", "7", "8", "9", "10", "11", "7", "9" ]
114
11,127
0
false
cis-Diamminedichloroplatinum(II) (cisplatin) has been widely used in chemotherapy for almost 30 years.
[ "Figure 1A" ]
cis-Diamminedichloroplatinum(II) (cisplatin) has been widely used in chemotherapy for almost 30 years.
false
true
true
true
false
1,780
0
INTRODUCTION
1
1
[ "B1", "B2", "B3", "B4 B5 B6", "B7", "B8", "B9", "B10", "B11", "B7", "B9" ]
17,329,374
NA|pmid-12102553|pmid-3317449|pmid-11525387|pmid-12630848|NA|pmid-11098823|pmid-570092|pmid-2431763|pmid-10561728|pmid-15294448|pmid-11098823|pmid-2431763|pmid-2431763|pmid-6538808|pmid-1749377
Hence, mechanisms underlying biological effects of this purely inorganic, simple, but outstanding compound have been intensively examined.
[ "1", "2", "3", "4–6", "7", "8", "9", "10", "11", "7", "9" ]
138
11,128
0
false
Hence, mechanisms underlying biological effects of this purely inorganic, simple, but outstanding compound have been intensively examined.
[]
Hence, mechanisms underlying biological effects of this purely inorganic, simple, but outstanding compound have been intensively examined.
true
true
true
true
true
1,780
0
INTRODUCTION
1
1
[ "B1", "B2", "B3", "B4 B5 B6", "B7", "B8", "B9", "B10", "B11", "B7", "B9" ]
17,329,374
NA|pmid-12102553|pmid-3317449|pmid-11525387|pmid-12630848|NA|pmid-11098823|pmid-570092|pmid-2431763|pmid-10561728|pmid-15294448|pmid-11098823|pmid-2431763|pmid-2431763|pmid-6538808|pmid-1749377
In spite of this intensive research lasting more than three decades, many important details of the mechanism of anticancer effects of cisplatin have not been so far clarified.
[ "1", "2", "3", "4–6", "7", "8", "9", "10", "11", "7", "9" ]
175
11,129
0
false
In spite of this intensive research lasting more than three decades, many important details of the mechanism of anticancer effects of cisplatin have not been so far clarified.
[]
In spite of this intensive research lasting more than three decades, many important details of the mechanism of anticancer effects of cisplatin have not been so far clarified.
true
true
true
true
true
1,780
0
INTRODUCTION
1
1
[ "B1", "B2", "B3", "B4 B5 B6", "B7", "B8", "B9", "B10", "B11", "B7", "B9" ]
17,329,374
NA|pmid-12102553|pmid-3317449|pmid-11525387|pmid-12630848|NA|pmid-11098823|pmid-570092|pmid-2431763|pmid-10561728|pmid-15294448|pmid-11098823|pmid-2431763|pmid-2431763|pmid-6538808|pmid-1749377
It is generally accepted that the major pharmacological target of cisplatin and other platinum anticancer compounds is DNA (1) and that the cytotoxicity of platinum compounds is thought to be determined primarily by their DNA adducts (2).
[ "1", "2", "3", "4–6", "7", "8", "9", "10", "11", "7", "9" ]
238
11,130
1
false
It is generally accepted that the major pharmacological target of cisplatin and other platinum anticancer compounds is DNA and that the cytotoxicity of platinum compounds is thought to be determined primarily by their DNA adducts.
[ "1", "2" ]
It is generally accepted that the major pharmacological target of cisplatin and other platinum anticancer compounds is DNA and that the cytotoxicity of platinum compounds is thought to be determined primarily by their DNA adducts.
true
true
true
true
true
1,780
0
INTRODUCTION
1
3
[ "B1", "B2", "B3", "B4 B5 B6", "B7", "B8", "B9", "B10", "B11", "B7", "B9" ]
17,329,374
NA|pmid-12102553|pmid-3317449|pmid-11525387|pmid-12630848|NA|pmid-11098823|pmid-570092|pmid-2431763|pmid-10561728|pmid-15294448|pmid-11098823|pmid-2431763|pmid-2431763|pmid-6538808|pmid-1749377
Numerous studies show that cisplatin forms in DNA ∼90% intrastrand cross-links (CLs) between neighboring purine bases (1,2-GG or 1,2-AG intrastrand CLs) and remaining lesions are intrastrand CLs between purine bases separated by a third base, interstrand CLs and monofunctional adducts (3) Structures, other physical pro...
[ "1", "2", "3", "4–6", "7", "8", "9", "10", "11", "7", "9" ]
474
11,131
1
false
Numerous studies show that cisplatin forms in DNA ∼90% intrastrand cross-links (CLs) between neighboring purine bases and remaining lesions are intrastrand CLs between purine bases separated by a third base, interstrand CLs and monofunctional adducts Structures, other physical properties of these adducts and their reco...
[ "1,2-GG or 1,2-AG intrastrand CLs", "3", "4–6" ]
Numerous studies show that cisplatin forms in DNA ∼90% intrastrand cross-links (CLs) between neighboring purine bases and remaining lesions are intrastrand CLs between purine bases separated by a third base, interstrand CLs and monofunctional adducts Structures, other physical properties of these adducts and their reco...
true
true
true
true
true
1,780
0
INTRODUCTION
1
1
[ "B1", "B2", "B3", "B4 B5 B6", "B7", "B8", "B9", "B10", "B11", "B7", "B9" ]
17,329,374
NA|pmid-12102553|pmid-3317449|pmid-11525387|pmid-12630848|NA|pmid-11098823|pmid-570092|pmid-2431763|pmid-10561728|pmid-15294448|pmid-11098823|pmid-2431763|pmid-2431763|pmid-6538808|pmid-1749377
Importantly, some studies indicate that cisplatin forms besides these DNA adducts also ternary DNA–platinum–protein CLs (DPCLs)
[ "1", "2", "3", "4–6", "7", "8", "9", "10", "11", "7", "9" ]
127
11,132
0
false
Importantly, some studies indicate that cisplatin forms besides these DNA adducts also ternary DNA–platinum–protein CLs (DPCLs)
[]
Importantly, some studies indicate that cisplatin forms besides these DNA adducts also ternary DNA–platinum–protein CLs (DPCLs)
true
true
false
true
false
1,780
0
INTRODUCTION
1
1
[ "B1", "B2", "B3", "B4 B5 B6", "B7", "B8", "B9", "B10", "B11", "B7", "B9" ]
17,329,374
NA|pmid-12102553|pmid-3317449|pmid-11525387|pmid-12630848|NA|pmid-11098823|pmid-570092|pmid-2431763|pmid-10561728|pmid-15294448|pmid-11098823|pmid-2431763|pmid-2431763|pmid-6538808|pmid-1749377
[see Wozniak and Walter (7) for review].
[ "1", "2", "3", "4–6", "7", "8", "9", "10", "11", "7", "9" ]
40
11,133
0
false
.
[ "see Wozniak and Walter (7) for review" ]
.
false
false
true
true
false
1,780
0
INTRODUCTION
1
1
[ "B1", "B2", "B3", "B4 B5 B6", "B7", "B8", "B9", "B10", "B11", "B7", "B9" ]
17,329,374
NA|pmid-12102553|pmid-3317449|pmid-11525387|pmid-12630848|NA|pmid-11098823|pmid-570092|pmid-2431763|pmid-10561728|pmid-15294448|pmid-11098823|pmid-2431763|pmid-2431763|pmid-6538808|pmid-1749377
For instance, cisplatin has been reported to cross-link chromosomal proteins, including histones or cytokeratins, to DNA (8,9).
[ "1", "2", "3", "4–6", "7", "8", "9", "10", "11", "7", "9" ]
127
11,134
0
false
For instance, cisplatin has been reported to cross-link chromosomal proteins, including histones or cytokeratins, to DNA.
[ "8,9" ]
For instance, cisplatin has been reported to cross-link chromosomal proteins, including histones or cytokeratins, to DNA.
true
true
true
true
true
1,780
0
INTRODUCTION
1
10
[ "B1", "B2", "B3", "B4 B5 B6", "B7", "B8", "B9", "B10", "B11", "B7", "B9" ]
17,329,374
NA|pmid-12102553|pmid-3317449|pmid-11525387|pmid-12630848|NA|pmid-11098823|pmid-570092|pmid-2431763|pmid-10561728|pmid-15294448|pmid-11098823|pmid-2431763|pmid-2431763|pmid-6538808|pmid-1749377
Interestingly, DPCLs have been shown to play an important role in cytotoxicity within the clinical dosage range of cisplatin (10), but frequency of these ternary complexes depends on the cell type (11) and time of the treatment (7,9).
[ "1", "2", "3", "4–6", "7", "8", "9", "10", "11", "7", "9" ]
234
11,135
1
false
Interestingly, DPCLs have been shown to play an important role in cytotoxicity within the clinical dosage range of cisplatin, but frequency of these ternary complexes depends on the cell type and time of the treatment.
[ "10", "11", "7,9" ]
Interestingly, DPCLs have been shown to play an important role in cytotoxicity within the clinical dosage range of cisplatin, but frequency of these ternary complexes depends on the cell type and time of the treatment.
true
true
true
true
true
1,780
0
INTRODUCTION
1
1
[ "B1", "B2", "B3", "B4 B5 B6", "B7", "B8", "B9", "B10", "B11", "B7", "B9" ]
17,329,374
NA|pmid-12102553|pmid-3317449|pmid-11525387|pmid-12630848|NA|pmid-11098823|pmid-570092|pmid-2431763|pmid-10561728|pmid-15294448|pmid-11098823|pmid-2431763|pmid-2431763|pmid-6538808|pmid-1749377
Figure 1.Structures of platinum compounds and sequences of the synthetic oligodeoxyribonucleotides with their abbreviations.
[ "1", "2", "3", "4–6", "7", "8", "9", "10", "11", "7", "9" ]
124
11,136
0
false
Figure 1.Structures of platinum compounds and sequences of the synthetic oligodeoxyribonucleotides with their abbreviations.
[]
Figure 1.Structures of platinum compounds and sequences of the synthetic oligodeoxyribonucleotides with their abbreviations.
true
true
true
true
true
1,780
0
INTRODUCTION
1
1
[ "B1", "B2", "B3", "B4 B5 B6", "B7", "B8", "B9", "B10", "B11", "B7", "B9" ]
17,329,374
NA|pmid-12102553|pmid-3317449|pmid-11525387|pmid-12630848|NA|pmid-11098823|pmid-570092|pmid-2431763|pmid-10561728|pmid-15294448|pmid-11098823|pmid-2431763|pmid-2431763|pmid-6538808|pmid-1749377
(A) Structures: a, cisplatin; b, transplatin.
[ "1", "2", "3", "4–6", "7", "8", "9", "10", "11", "7", "9" ]
45
11,137
0
false
(A) Structures: a, cisplatin; b, transplatin.
[]
(A) Structures: a, cisplatin; b, transplatin.
false
false
true
true
false
1,780
0
INTRODUCTION
1
1
[ "B1", "B2", "B3", "B4 B5 B6", "B7", "B8", "B9", "B10", "B11", "B7", "B9" ]
17,329,374
NA|pmid-12102553|pmid-3317449|pmid-11525387|pmid-12630848|NA|pmid-11098823|pmid-570092|pmid-2431763|pmid-10561728|pmid-15294448|pmid-11098823|pmid-2431763|pmid-2431763|pmid-6538808|pmid-1749377
(B) Sequences: the top and bottom strands of each pair in the figure are designated ‘top’ and ‘bottom’, respectively, throughout.
[ "1", "2", "3", "4–6", "7", "8", "9", "10", "11", "7", "9" ]
129
11,138
0
false
(B) Sequences: the top and bottom strands of each pair in the figure are designated ‘top’ and ‘bottom’, respectively, throughout.
[]
(B) Sequences: the top and bottom strands of each pair in the figure are designated ‘top’ and ‘bottom’, respectively, throughout.
false
false
true
true
false
1,780
0
INTRODUCTION
1
1
[ "B1", "B2", "B3", "B4 B5 B6", "B7", "B8", "B9", "B10", "B11", "B7", "B9" ]
17,329,374
NA|pmid-12102553|pmid-3317449|pmid-11525387|pmid-12630848|NA|pmid-11098823|pmid-570092|pmid-2431763|pmid-10561728|pmid-15294448|pmid-11098823|pmid-2431763|pmid-2431763|pmid-6538808|pmid-1749377
The boldface letters in the top strands of the duplexes TGGT(20), TGTGT(20), TGCT(20), TGT(20) and TGGT(NER) indicate the platinated residues.
[ "1", "2", "3", "4–6", "7", "8", "9", "10", "11", "7", "9" ]
142
11,139
0
false
The boldface letters in the top strands of the duplexes TGGT, TGTGT, TGCT, TGT and TGGT(NER) indicate the platinated residues.
[ "20", "20", "20", "20" ]
The boldface letters in the top strands of the duplexes TGGT, TGTGT, TGCT, TGT and TGGT(NER) indicate the platinated residues.
true
true
true
true
true
1,780
1
INTRODUCTION
0
null
null
17,329,374
pmid-8525382|pmid-10101191|pmid-2000402
Structures of platinum compounds and sequences of the synthetic oligodeoxyribonucleotides with their abbreviations.
null
115
11,140
0
false
null
null
Structures of platinum compounds and sequences of the synthetic oligodeoxyribonucleotides with their abbreviations.
true
true
true
true
true
1,781
1
INTRODUCTION
0
null
null
17,329,374
pmid-8525382|pmid-10101191|pmid-2000402
(A) Structures: a, cisplatin; b, transplatin.
null
45
11,141
0
false
null
null
(A) Structures: a, cisplatin; b, transplatin.
false
false
true
true
false
1,781
1
INTRODUCTION
0
null
null
17,329,374
pmid-8525382|pmid-10101191|pmid-2000402
(B) Sequences: the top and bottom strands of each pair in the figure are designated ‘top’ and ‘bottom’, respectively, throughout.
null
129
11,142
0
false
null
null
(B) Sequences: the top and bottom strands of each pair in the figure are designated ‘top’ and ‘bottom’, respectively, throughout.
false
false
true
true
false
1,781
1
INTRODUCTION
0
null
null
17,329,374
pmid-8525382|pmid-10101191|pmid-2000402
The boldface letters in the top strands of the duplexes TGGT(20), TGTGT(20), TGCT(20), TGT(20) and TGGT(NER) indicate the platinated residues.
null
142
11,143
0
false
null
null
The boldface letters in the top strands of the duplexes TGGT(20), TGTGT(20), TGCT(20), TGT(20) and TGGT(NER) indicate the platinated residues.
true
true
true
true
true
1,781
2
INTRODUCTION
1
4
[ "B4", "B12", "B13", "B14", "B15" ]
17,329,374
pmid-11525387|pmid-11749487|pmid-11406166|pmid-12119176|pmid-14602903|NA
Several models of the mechanism underlying antitumor effects of cisplatin have been already presented, but several have not taken into account the existence and specific properties of the DPCLs formed by this drug (4,12,13).
[ "4", "12", "13", "14", "15" ]
224
11,144
0
false
Several models of the mechanism underlying antitumor effects of cisplatin have been already presented, but several have not taken into account the existence and specific properties of the DPCLs formed by this drug.
[ "4,12,13" ]
Several models of the mechanism underlying antitumor effects of cisplatin have been already presented, but several have not taken into account the existence and specific properties of the DPCLs formed by this drug.
true
true
true
true
true
1,782
2
INTRODUCTION
1
4
[ "B4", "B12", "B13", "B14", "B15" ]
17,329,374
pmid-11525387|pmid-11749487|pmid-11406166|pmid-12119176|pmid-14602903|NA
Nevertheless, a few studies have been performed.
[ "4", "12", "13", "14", "15" ]
48
11,145
0
false
Nevertheless, a few studies have been performed.
[]
Nevertheless, a few studies have been performed.
true
true
true
true
true
1,782
2
INTRODUCTION
1
14
[ "B4", "B12", "B13", "B14", "B15" ]
17,329,374
pmid-11525387|pmid-11749487|pmid-11406166|pmid-12119176|pmid-14602903|NA
For instance, it has been shown that the participation of nuclear proteins in DPCLs induced by cisplatin can disturb the nuclear metabolism and the spatial organization of chromatin (14).
[ "4", "12", "13", "14", "15" ]
187
11,146
1
false
For instance, it has been shown that the participation of nuclear proteins in DPCLs induced by cisplatin can disturb the nuclear metabolism and the spatial organization of chromatin.
[ "14" ]
For instance, it has been shown that the participation of nuclear proteins in DPCLs induced by cisplatin can disturb the nuclear metabolism and the spatial organization of chromatin.
true
true
true
true
true
1,782
2
INTRODUCTION
1
15
[ "B4", "B12", "B13", "B14", "B15" ]
17,329,374
pmid-11525387|pmid-11749487|pmid-11406166|pmid-12119176|pmid-14602903|NA
Also interestingly, the DPCLs (formed by antitumor trans-[PtCl2(E-iminoether)2]) inhibit DNA replication, DNA repair and are recognized by cellular components distinctly differently than plain Pt–DNA adducts (containing no proteins) (15).
[ "4", "12", "13", "14", "15" ]
238
11,147
1
false
Also interestingly, the DPCLs (formed by antitumor trans-[PtCl2(E-iminoether)2]) inhibit DNA replication, DNA repair and are recognized by cellular components distinctly differently than plain Pt–DNA adducts (containing no proteins).
[ "15" ]
Also interestingly, the DPCLs (formed by antitumor trans-[PtCl2(E-iminoether)2]) inhibit DNA replication, DNA repair and are recognized by cellular components distinctly differently than plain Pt–DNA adducts (containing no proteins).
true
true
true
true
true
1,782
2
INTRODUCTION
1
4
[ "B4", "B12", "B13", "B14", "B15" ]
17,329,374
pmid-11525387|pmid-11749487|pmid-11406166|pmid-12119176|pmid-14602903|NA
In aggregate, DPCLs formed by cisplatin have not been so far studied as intensively as the adducts formed by this metallodrug only within DNA.
[ "4", "12", "13", "14", "15" ]
142
11,148
0
false
In aggregate, DPCLs formed by cisplatin have not been so far studied as intensively as the adducts formed by this metallodrug only within DNA.
[]
In aggregate, DPCLs formed by cisplatin have not been so far studied as intensively as the adducts formed by this metallodrug only within DNA.
true
true
true
true
true
1,782
2
INTRODUCTION
1
4
[ "B4", "B12", "B13", "B14", "B15" ]
17,329,374
pmid-11525387|pmid-11749487|pmid-11406166|pmid-12119176|pmid-14602903|NA
Hence, despite the biological significance of DPCLs, much remains to be learned about the mechanism of formation of these ternary complexes.
[ "4", "12", "13", "14", "15" ]
140
11,149
0
false
Hence, despite the biological significance of DPCLs, much remains to be learned about the mechanism of formation of these ternary complexes.
[]
Hence, despite the biological significance of DPCLs, much remains to be learned about the mechanism of formation of these ternary complexes.
true
true
true
true
true
1,782
3
INTRODUCTION
1
16
[ "B16" ]
17,329,374
pmid-2204440|pmid-6538808|pmid-10561728|NA
To further elucidate the nature of DNA–cisplatin–protein CLs, we have examined mechanism of the origin of these DPCLs and their cellular processing on molecular level.
[ "16" ]
167
11,150
0
false
To further elucidate the nature of DNA–cisplatin–protein CLs, we have examined mechanism of the origin of these DPCLs and their cellular processing on molecular level.
[]
To further elucidate the nature of DNA–cisplatin–protein CLs, we have examined mechanism of the origin of these DPCLs and their cellular processing on molecular level.
true
true
true
true
true
1,783
3
INTRODUCTION
1
16
[ "B16" ]
17,329,374
pmid-2204440|pmid-6538808|pmid-10561728|NA
A long-term goal of our studies in the field of platinum anticancer drugs is to contribute to the improvement of the structure–pharmacological relationship of platinum compounds.
[ "16" ]
178
11,151
0
false
A long-term goal of our studies in the field of platinum anticancer drugs is to contribute to the improvement of the structure–pharmacological relationship of platinum compounds.
[]
A long-term goal of our studies in the field of platinum anticancer drugs is to contribute to the improvement of the structure–pharmacological relationship of platinum compounds.
true
true
true
true
true
1,783
3
INTRODUCTION
1
16
[ "B16" ]
17,329,374
pmid-2204440|pmid-6538808|pmid-10561728|NA
Such studies also often employ comparisons between the effects of cisplatin and clinically ineffective trans analogue (trans-diamminedichloridoplatinum(II), transplatin) (Figure 1A) (16).
[ "16" ]
187
11,152
1
false
Such studies also often employ comparisons between the effects of cisplatin and clinically ineffective trans analogue (trans-diamminedichloridoplatinum(II), transplatin) (Figure 1A).
[ "16" ]
Such studies also often employ comparisons between the effects of cisplatin and clinically ineffective trans analogue (trans-diamminedichloridoplatinum(II), transplatin).
true
true
true
true
true
1,783
3
INTRODUCTION
1
16
[ "B16" ]
17,329,374
pmid-2204440|pmid-6538808|pmid-10561728|NA
Therefore, we also performed in parallel some studies aimed at the effects of transplatin.
[ "16" ]
90
11,153
0
false
Therefore, we also performed in parallel some studies aimed at the effects of transplatin.
[]
Therefore, we also performed in parallel some studies aimed at the effects of transplatin.
true
true
true
true
true
1,783
0
DISCUSSION
1
9
[ "B9", "B33", "B34" ]
17,329,374
NA|pmid-12102553|pmid-3317449|pmid-11525387|pmid-12630848|NA|pmid-11098823|pmid-570092|pmid-2431763|pmid-10561728|pmid-15294448|pmid-11098823|pmid-2431763|pmid-2431763|pmid-6538808|pmid-1749377
In spite of the fact that the role of DNA adducts in the mechanism of antitumor effects of cisplatin and its analogues has been extensively examined, the significance of the DPCLs in which DNA and proteins are covalently linked by these platinum complexes has not been always fully appreciated.
[ "9", "33", "34" ]
294
11,154
0
false
In spite of the fact that the role of DNA adducts in the mechanism of antitumor effects of cisplatin and its analogues has been extensively examined, the significance of the DPCLs in which DNA and proteins are covalently linked by these platinum complexes has not been always fully appreciated.
[]
In spite of the fact that the role of DNA adducts in the mechanism of antitumor effects of cisplatin and its analogues has been extensively examined, the significance of the DPCLs in which DNA and proteins are covalently linked by these platinum complexes has not been always fully appreciated.
true
true
true
true
true
1,784
0
DISCUSSION
1
9
[ "B9", "B33", "B34" ]
17,329,374
NA|pmid-12102553|pmid-3317449|pmid-11525387|pmid-12630848|NA|pmid-11098823|pmid-570092|pmid-2431763|pmid-10561728|pmid-15294448|pmid-11098823|pmid-2431763|pmid-2431763|pmid-6538808|pmid-1749377
Hence, the mechanism of the origin of these DPCLs has not been so far investigated in such details as other (plain) DNA adducts of platinum compounds (containing no protein).
[ "9", "33", "34" ]
174
11,155
0
false
Hence, the mechanism of the origin of these DPCLs has not been so far investigated in such details as other (plain) DNA adducts of platinum compounds (containing no protein).
[]
Hence, the mechanism of the origin of these DPCLs has not been so far investigated in such details as other (plain) DNA adducts of platinum compounds (containing no protein).
true
true
true
true
true
1,784
0
DISCUSSION
1
9
[ "B9", "B33", "B34" ]
17,329,374
NA|pmid-12102553|pmid-3317449|pmid-11525387|pmid-12630848|NA|pmid-11098823|pmid-570092|pmid-2431763|pmid-10561728|pmid-15294448|pmid-11098823|pmid-2431763|pmid-2431763|pmid-6538808|pmid-1749377
We show in this work that in cell-free media cisplatin forms DPCLs considerably more effectively than clinically ineffective transplatin (Figures 2 and 3 and Table 1).
[ "9", "33", "34" ]
167
11,156
0
false
We show in this work that in cell-free media cisplatin forms DPCLs considerably more effectively than clinically ineffective transplatin (Figures 2 and 3 and Table 1).
[]
We show in this work that in cell-free media cisplatin forms DPCLs considerably more effectively than clinically ineffective transplatin (Figures 2 and 3 and Table 1).
true
true
true
true
true
1,784
0
DISCUSSION
1
9
[ "B9", "B33", "B34" ]
17,329,374
NA|pmid-12102553|pmid-3317449|pmid-11525387|pmid-12630848|NA|pmid-11098823|pmid-570092|pmid-2431763|pmid-10561728|pmid-15294448|pmid-11098823|pmid-2431763|pmid-2431763|pmid-6538808|pmid-1749377
It implies that there is a positive correlation between the efficiency of mononuclear bifunctional platinum complexes to form DPCLs and their antitumor effects.
[ "9", "33", "34" ]
160
11,157
0
false
It implies that there is a positive correlation between the efficiency of mononuclear bifunctional platinum complexes to form DPCLs and their antitumor effects.
[]
It implies that there is a positive correlation between the efficiency of mononuclear bifunctional platinum complexes to form DPCLs and their antitumor effects.
true
true
true
true
true
1,784
0
DISCUSSION
1
9
[ "B9", "B33", "B34" ]
17,329,374
NA|pmid-12102553|pmid-3317449|pmid-11525387|pmid-12630848|NA|pmid-11098823|pmid-570092|pmid-2431763|pmid-10561728|pmid-15294448|pmid-11098823|pmid-2431763|pmid-2431763|pmid-6538808|pmid-1749377
Thus, the results of the present work are consistent with previous findings demonstrating that DPCLs persist longer in cells exposed to cisplatin than in those exposed to the chemotherapeutically inactive trans analogue (9,33,34), which suggests relevance of such lesions to antitumor effects of cisplatin.
[ "9", "33", "34" ]
306
11,158
0
false
Thus, the results of the present work are consistent with previous findings demonstrating that DPCLs persist longer in cells exposed to cisplatin than in those exposed to the chemotherapeutically inactive trans analogue, which suggests relevance of such lesions to antitumor effects of cisplatin.
[ "9,33,34" ]
Thus, the results of the present work are consistent with previous findings demonstrating that DPCLs persist longer in cells exposed to cisplatin than in those exposed to the chemotherapeutically inactive trans analogue, which suggests relevance of such lesions to antitumor effects of cisplatin.
true
true
true
true
true
1,784
1
DISCUSSION
1
35
[ "B35", "B36", "B37" ]
17,329,374
pmid-8525382|pmid-10101191|pmid-2000402
In the present work, we paid attention to some aspects of the mechanism of the origin of the DPCLs by cisplatin, in particular to the mechanism of transformation of individual types of plain DNA adducts of cisplatin (and transplatin) into the DPCLs.
[ "35", "36", "37" ]
249
11,159
0
false
In the present work, we paid attention to some aspects of the mechanism of the origin of the DPCLs by cisplatin, in particular to the mechanism of transformation of individual types of plain DNA adducts of cisplatin (and transplatin) into the DPCLs.
[]
In the present work, we paid attention to some aspects of the mechanism of the origin of the DPCLs by cisplatin, in particular to the mechanism of transformation of individual types of plain DNA adducts of cisplatin (and transplatin) into the DPCLs.
true
true
true
true
true
1,785
1
DISCUSSION
1
35
[ "B35", "B36", "B37" ]
17,329,374
pmid-8525382|pmid-10101191|pmid-2000402
We assumed initially that the DPCLs may originate mostly from monofunctional adducts of cisplatin.
[ "35", "36", "37" ]
98
11,160
0
false
We assumed initially that the DPCLs may originate mostly from monofunctional adducts of cisplatin.
[]
We assumed initially that the DPCLs may originate mostly from monofunctional adducts of cisplatin.
true
true
true
true
true
1,785
1
DISCUSSION
1
35
[ "B35", "B36", "B37" ]
17,329,374
pmid-8525382|pmid-10101191|pmid-2000402
However, quite strikingly, the DPCLs also origin with a roughly identical efficiency by the transformation of DNA intrastrand CLs of cisplatin (Figure 4).
[ "35", "36", "37" ]
154
11,161
0
false
However, quite strikingly, the DPCLs also origin with a roughly identical efficiency by the transformation of DNA intrastrand CLs of cisplatin (Figure 4).
[]
However, quite strikingly, the DPCLs also origin with a roughly identical efficiency by the transformation of DNA intrastrand CLs of cisplatin (Figure 4).
true
true
true
true
true
1,785
1
DISCUSSION
1
35
[ "B35", "B36", "B37" ]
17,329,374
pmid-8525382|pmid-10101191|pmid-2000402
In contrast, DNA interstrand CLs of cisplatin are markedly more stable in the presence of DNA-binding proteins than DNA intrastrand CLs of this metallodrug so that their transformation into DPCLs is markedly more difficult.
[ "35", "36", "37" ]
223
11,162
0
false
In contrast, DNA interstrand CLs of cisplatin are markedly more stable in the presence of DNA-binding proteins than DNA intrastrand CLs of this metallodrug so that their transformation into DPCLs is markedly more difficult.
[]
In contrast, DNA interstrand CLs of cisplatin are markedly more stable in the presence of DNA-binding proteins than DNA intrastrand CLs of this metallodrug so that their transformation into DPCLs is markedly more difficult.
true
true
true
true
true
1,785
1
DISCUSSION
1
35
[ "B35", "B36", "B37" ]
17,329,374
pmid-8525382|pmid-10101191|pmid-2000402
This observation may be associated with a rather severe conformational distortion induced in DNA by interstrand CLs of cisplatin (35,36).
[ "35", "36", "37" ]
137
11,163
0
false
This observation may be associated with a rather severe conformational distortion induced in DNA by interstrand CLs of cisplatin.
[ "35,36" ]
This observation may be associated with a rather severe conformational distortion induced in DNA by interstrand CLs of cisplatin.
true
true
true
true
true
1,785
1
DISCUSSION
1
37
[ "B35", "B36", "B37" ]
17,329,374
pmid-8525382|pmid-10101191|pmid-2000402
The interstrand CL is preferentially formed by cisplatin between opposite guanine residues in the 5′-GC/5′-GC sequence (37).
[ "35", "36", "37" ]
124
11,164
1
false
The interstrand CL is preferentially formed by cisplatin between opposite guanine residues in the 5′-GC/5′-GC sequence.
[ "37" ]
The interstrand CL is preferentially formed by cisplatin between opposite guanine residues in the 5′-GC/5′-GC sequence.
true
true
true
true
true
1,785
1
DISCUSSION
1
35
[ "B35", "B36", "B37" ]
17,329,374
pmid-8525382|pmid-10101191|pmid-2000402
The cross-linked guanine residues are not paired with hydrogen bonds to the complementary cytosines, which are located outside the duplex and not stacked with other aromatic rings.
[ "35", "36", "37" ]
180
11,165
0
false
The cross-linked guanine residues are not paired with hydrogen bonds to the complementary cytosines, which are located outside the duplex and not stacked with other aromatic rings.
[]
The cross-linked guanine residues are not paired with hydrogen bonds to the complementary cytosines, which are located outside the duplex and not stacked with other aromatic rings.
true
true
true
true
true
1,785
1
DISCUSSION
1
35
[ "B35", "B36", "B37" ]
17,329,374
pmid-8525382|pmid-10101191|pmid-2000402
All other base residues are paired, but distortion extends over at least 4 bp at the site of the CL.
[ "35", "36", "37" ]
100
11,166
0
false
All other base residues are paired, but distortion extends over at least 4 bp at the site of the CL.
[]
All other base residues are paired, but distortion extends over at least 4 bp at the site of the CL.
true
true
true
true
true
1,785
1
DISCUSSION
1
35
[ "B35", "B36", "B37" ]
17,329,374
pmid-8525382|pmid-10101191|pmid-2000402
In addition, the cis-diammineplatinum(II) bridge resides in the minor groove and the double helix is locally reversed to a left-handed, Z-DNA-like form.
[ "35", "36", "37" ]
152
11,167
0
false
In addition, the cis-diammineplatinum(II) bridge resides in the minor groove and the double helix is locally reversed to a left-handed, Z-DNA-like form.
[]
In addition, the cis-diammineplatinum(II) bridge resides in the minor groove and the double helix is locally reversed to a left-handed, Z-DNA-like form.
true
true
true
true
true
1,785
1
DISCUSSION
1
35
[ "B35", "B36", "B37" ]
17,329,374
pmid-8525382|pmid-10101191|pmid-2000402
This adduct induces the helix unwinding by 76–80° relative to B–DNA and also the bending of 20–40° of the helix axis at the cross-linked site toward the minor groove.
[ "35", "36", "37" ]
166
11,168
0
false
This adduct induces the helix unwinding by 76–80° relative to B–DNA and also the bending of 20–40° of the helix axis at the cross-linked site toward the minor groove.
[]
This adduct induces the helix unwinding by 76–80° relative to B–DNA and also the bending of 20–40° of the helix axis at the cross-linked site toward the minor groove.
true
true
true
true
true
1,785
1
DISCUSSION
1
35
[ "B35", "B36", "B37" ]
17,329,374
pmid-8525382|pmid-10101191|pmid-2000402
If the DPCL is formed from DNA adducts of cisplatin, it is necessary for DNA-binding protein to come into a very close contact with DNA at the site of the platinum adduct and to bind to DNA at this site relatively strongly.
[ "35", "36", "37" ]
223
11,169
0
false
If the DPCL is formed from DNA adducts of cisplatin, it is necessary for DNA-binding protein to come into a very close contact with DNA at the site of the platinum adduct and to bind to DNA at this site relatively strongly.
[]
If the DPCL is formed from DNA adducts of cisplatin, it is necessary for DNA-binding protein to come into a very close contact with DNA at the site of the platinum adduct and to bind to DNA at this site relatively strongly.
true
true
true
true
true
1,785
1
DISCUSSION
1
35
[ "B35", "B36", "B37" ]
17,329,374
pmid-8525382|pmid-10101191|pmid-2000402
This may not be easily achieved in the case of DNA heavily distorted by the interstrand CL of cisplatin in contrast to other, less distorting, DNA adducts of this drug.
[ "35", "36", "37" ]
168
11,170
0
false
This may not be easily achieved in the case of DNA heavily distorted by the interstrand CL of cisplatin in contrast to other, less distorting, DNA adducts of this drug.
[]
This may not be easily achieved in the case of DNA heavily distorted by the interstrand CL of cisplatin in contrast to other, less distorting, DNA adducts of this drug.
true
true
true
true
true
1,785
2
DISCUSSION
1
38
[ "B38" ]
17,329,374
pmid-11525387|pmid-11749487|pmid-11406166|pmid-12119176|pmid-14602903|NA
It is also demonstrated in the present work that frequent monofunctional adducts of clinically ineffective transplatin are also transformed into DPCLs, but much less efficiently that intrastrand CLs or monofunctional adducts of cisplatin (Figure 4).
[ "38" ]
249
11,171
0
false
It is also demonstrated in the present work that frequent monofunctional adducts of clinically ineffective transplatin are also transformed into DPCLs, but much less efficiently that intrastrand CLs or monofunctional adducts of cisplatin (Figure 4).
[]
It is also demonstrated in the present work that frequent monofunctional adducts of clinically ineffective transplatin are also transformed into DPCLs, but much less efficiently that intrastrand CLs or monofunctional adducts of cisplatin (Figure 4).
true
true
true
true
true
1,786
2
DISCUSSION
1
38
[ "B38" ]
17,329,374
pmid-11525387|pmid-11749487|pmid-11406166|pmid-12119176|pmid-14602903|NA
This observation is consistent with the fact that in general monofunctional adducts of bifunctional transplatinum complexes undergo chelation reactions less readily than those of cisplatinum complexes (38).
[ "38" ]
206
11,172
1
false
This observation is consistent with the fact that in general monofunctional adducts of bifunctional transplatinum complexes undergo chelation reactions less readily than those of cisplatinum complexes.
[ "38" ]
This observation is consistent with the fact that in general monofunctional adducts of bifunctional transplatinum complexes undergo chelation reactions less readily than those of cisplatinum complexes.
true
true
true
true
true
1,786
3
DISCUSSION
1
33
[ "B33", "B10", "B39" ]
17,329,374
pmid-2204440|pmid-6538808|pmid-10561728|NA
It has been also demonstrated by others that the frequency of DPCLs in tumor cells treated with cisplatin is comparable with that of plain DNA interstrand CLs of this drug (33) or is even markedly higher (10).
[ "33", "10", "39" ]
209
11,173
1
false
It has been also demonstrated by others that the frequency of DPCLs in tumor cells treated with cisplatin is comparable with that of plain DNA interstrand CLs of this drug or is even markedly higher.
[ "33", "10" ]
It has been also demonstrated by others that the frequency of DPCLs in tumor cells treated with cisplatin is comparable with that of plain DNA interstrand CLs of this drug or is even markedly higher.
true
true
true
true
true
1,787
3
DISCUSSION
1
39
[ "B33", "B10", "B39" ]
17,329,374
pmid-2204440|pmid-6538808|pmid-10561728|NA
Thus, considering the bulky nature of DPCLs it is likely that these lesions formed by cisplatin represent a more distinct and persisting structural motif recognized by the components of downstream cellular systems processing DNA damage considerably differently than the plain DNA adducts of this metallodrug (39).
[ "33", "10", "39" ]
313
11,174
1
false
Thus, considering the bulky nature of DPCLs it is likely that these lesions formed by cisplatin represent a more distinct and persisting structural motif recognized by the components of downstream cellular systems processing DNA damage considerably differently than the plain DNA adducts of this metallodrug.
[ "39" ]
Thus, considering the bulky nature of DPCLs it is likely that these lesions formed by cisplatin represent a more distinct and persisting structural motif recognized by the components of downstream cellular systems processing DNA damage considerably differently than the plain DNA adducts of this metallodrug.
true
true
true
true
true
1,787
3
DISCUSSION
1
33
[ "B33", "B10", "B39" ]
17,329,374
pmid-2204440|pmid-6538808|pmid-10561728|NA
This conclusion is corroborated by the results of the present work (Figures 5 and 6) demonstrating that DPCLs linked by cisplatin inhibit DNA polymerization or removal of major cisplatin adducts from DNA by NER systems much more efficiently than the plain DNA adducts (not linked to proteins).
[ "33", "10", "39" ]
293
11,175
0
false
This conclusion is corroborated by the results of the present work (Figures 5 and 6) demonstrating that DPCLs linked by cisplatin inhibit DNA polymerization or removal of major cisplatin adducts from DNA by NER systems much more efficiently than the plain DNA adducts (not linked to proteins).
[]
This conclusion is corroborated by the results of the present work (Figures 5 and 6) demonstrating that DPCLs linked by cisplatin inhibit DNA polymerization or removal of major cisplatin adducts from DNA by NER systems much more efficiently than the plain DNA adducts (not linked to proteins).
true
true
true
true
true
1,787
4
DISCUSSION
1
15
[ "B15", "B40", "B40" ]
17,329,374
pmid-14602903|pmid-16537484|pmid-16537484
Our observation (Figure 6) that the mammalian NER system did not remove proteins cross-linked to DNA at a detectable level deserves further discussion.
[ "15", "40", "40" ]
151
11,176
0
false
Our observation (Figure 6) that the mammalian NER system did not remove proteins cross-linked to DNA at a detectable level deserves further discussion.
[]
Our observation (Figure 6) that the mammalian NER system did not remove proteins cross-linked to DNA at a detectable level deserves further discussion.
true
true
true
true
true
1,788
4
DISCUSSION
1
15
[ "B15", "B40", "B40" ]
17,329,374
pmid-14602903|pmid-16537484|pmid-16537484
This phenomenon was first observed by us 3 years ago (15).
[ "15", "40", "40" ]
58
11,177
1
false
This phenomenon was first observed by us 3 years ago.
[ "15" ]
This phenomenon was first observed by us 3 years ago.
true
true
true
true
true
1,788
4
DISCUSSION
1
15
[ "B15", "B40", "B40" ]
17,329,374
pmid-14602903|pmid-16537484|pmid-16537484
We investigated in this recent work excision by mammalian repair systems of the DNA–protein CL formed by another antitumor platinum drug, trans-[PtCl2(E-iminoether)2], between 148 bp DNA fragment and 20 kDa histone H1 and found that such bulky DNA–protein CLs were not removed.
[ "15", "40", "40" ]
277
11,178
0
false
We investigated in this recent work excision by mammalian repair systems of the DNA–protein CL formed by another antitumor platinum drug, trans-[PtCl2(E-iminoether)2], between 148 bp DNA fragment and 20 kDa histone H1 and found that such bulky DNA–protein CLs were not removed.
[]
We investigated in this recent work excision by mammalian repair systems of the DNA–protein CL formed by another antitumor platinum drug, trans-[PtCl2(E-iminoether)2], between 148 bp DNA fragment and 20 kDa histone H1 and found that such bulky DNA–protein CLs were not removed.
true
true
true
true
true
1,788
4
DISCUSSION
1
40
[ "B15", "B40", "B40" ]
17,329,374
pmid-14602903|pmid-16537484|pmid-16537484
Quite recently, our earlier results have been confirmed by others (40) demonstrating that the human NER system did not remove other, also bulky 16 kDa protein (T4 pyrimidine dimer glycosylase) cross-linked to DNA.
[ "15", "40", "40" ]
213
11,179
1
false
Quite recently, our earlier results have been confirmed by others demonstrating that the human NER system did not remove other, also bulky 16 kDa protein (T4 pyrimidine dimer glycosylase) cross-linked to DNA.
[ "40" ]
Quite recently, our earlier results have been confirmed by others demonstrating that the human NER system did not remove other, also bulky 16 kDa protein cross-linked to DNA.
true
true
true
true
true
1,788
4
DISCUSSION
1
40
[ "B15", "B40", "B40" ]
17,329,374
pmid-14602903|pmid-16537484|pmid-16537484
It has been also suggested (40) that the failure to remove DNA–bulky protein CLs is due to the steric hindrance caused by the size of the cross-linked protein that may interfere sterically with the assembly of the mammalian excision system.
[ "15", "40", "40" ]
240
11,180
1
false
It has been also suggested that the failure to remove DNA–bulky protein CLs is due to the steric hindrance caused by the size of the cross-linked protein that may interfere sterically with the assembly of the mammalian excision system.
[ "40" ]
It has been also suggested that the failure to remove DNA–bulky protein CLs is due to the steric hindrance caused by the size of the cross-linked protein that may interfere sterically with the assembly of the mammalian excision system.
true
true
true
true
true
1,788
4
DISCUSSION
1
15
[ "B15", "B40", "B40" ]
17,329,374
pmid-14602903|pmid-16537484|pmid-16537484
Thus, our results demonstrating failure of the mammalian NER system to remove the DNA–Pt–protein CLs reinforce the view that DNA–protein CLs formed by platinum drugs may be among the critical lesions relevant to their antitumor effects.
[ "15", "40", "40" ]
236
11,181
0
false
Thus, our results demonstrating failure of the mammalian NER system to remove the DNA–Pt–protein CLs reinforce the view that DNA–protein CLs formed by platinum drugs may be among the critical lesions relevant to their antitumor effects.
[]
Thus, our results demonstrating failure of the mammalian NER system to remove the DNA–Pt–protein CLs reinforce the view that DNA–protein CLs formed by platinum drugs may be among the critical lesions relevant to their antitumor effects.
true
true
true
true
true
1,788
4
DISCUSSION
1
15
[ "B15", "B40", "B40" ]
17,329,374
pmid-14602903|pmid-16537484|pmid-16537484
Other proteins known to specifically bind to cisplatin–DNA lesions and proteins involved in damage recognition and repair signaling will be used in our future research to obtain more details on processing DNA damage by cisplatin in vivo.
[ "15", "40", "40" ]
237
11,182
0
false
Other proteins known to specifically bind to cisplatin–DNA lesions and proteins involved in damage recognition and repair signaling will be used in our future research to obtain more details on processing DNA damage by cisplatin in vivo.
[]
Other proteins known to specifically bind to cisplatin–DNA lesions and proteins involved in damage recognition and repair signaling will be used in our future research to obtain more details on processing DNA damage by cisplatin in vivo.
true
true
true
true
true
1,788
5
DISCUSSION
1
9
[ "B9", "B33", "B41" ]
17,329,374
pmid-2431763|pmid-6538808|pmid-3552211
The results of the present work also demonstrate that in cell-free media transplatin forms less DPCLs than cisplatin (Figures 2 and 3).
[ "9", "33", "41" ]
135
11,183
0
false
The results of the present work also demonstrate that in cell-free media transplatin forms less DPCLs than cisplatin (Figures 2 and 3).
[]
The results of the present work also demonstrate that in cell-free media transplatin forms less DPCLs than cisplatin (Figures 2 and 3).
true
true
true
true
true
1,789
5
DISCUSSION
1
9
[ "B9", "B33", "B41" ]
17,329,374
pmid-2431763|pmid-6538808|pmid-3552211
This result may seem to contradict conclusions published earlier by others according to which transplatin forms considerably more DPCLs than cisplatin (9,33).
[ "9", "33", "41" ]
158
11,184
0
false
This result may seem to contradict conclusions published earlier by others according to which transplatin forms considerably more DPCLs than cisplatin.
[ "9,33" ]
This result may seem to contradict conclusions published earlier by others according to which transplatin forms considerably more DPCLs than cisplatin.
true
true
true
true
true
1,789
5
DISCUSSION
1
9
[ "B9", "B33", "B41" ]
17,329,374
pmid-2431763|pmid-6538808|pmid-3552211
However, these earlier conclusions have been drawn on the basis of the results obtained with the cells treated with equitoxic doses of cisplatin and transplatin, demonstrating a much higher molar concentration for transplatin.
[ "9", "33", "41" ]
226
11,185
0
false
However, these earlier conclusions have been drawn on the basis of the results obtained with the cells treated with equitoxic doses of cisplatin and transplatin, demonstrating a much higher molar concentration for transplatin.
[]
However, these earlier conclusions have been drawn on the basis of the results obtained with the cells treated with equitoxic doses of cisplatin and transplatin, demonstrating a much higher molar concentration for transplatin.
true
true
true
true
true
1,789
5
DISCUSSION
1
9
[ "B9", "B33", "B41" ]
17,329,374
pmid-2431763|pmid-6538808|pmid-3552211
Thus, if these results are normalized to the identical level of DNA platination, then in accordance with the results of the present work transplatin is much less effective agent capable of forming DPCLs than cisplatin.
[ "9", "33", "41" ]
218
11,186
0
false
Thus, if these results are normalized to the identical level of DNA platination, then in accordance with the results of the present work transplatin is much less effective agent capable of forming DPCLs than cisplatin.
[]
Thus, if these results are normalized to the identical level of DNA platination, then in accordance with the results of the present work transplatin is much less effective agent capable of forming DPCLs than cisplatin.
true
true
true
true
true
1,789
5
DISCUSSION
1
41
[ "B9", "B33", "B41" ]
17,329,374
pmid-2431763|pmid-6538808|pmid-3552211
It is generally assumed that cytotoxic DNA adduct of antitumor drug has to be fairly persistent (41).
[ "9", "33", "41" ]
101
11,187
1
false
It is generally assumed that cytotoxic DNA adduct of antitumor drug has to be fairly persistent.
[ "41" ]
It is generally assumed that cytotoxic DNA adduct of antitumor drug has to be fairly persistent.
true
true
true
true
true
1,789
5
DISCUSSION
1
9
[ "B9", "B33", "B41" ]
17,329,374
pmid-2431763|pmid-6538808|pmid-3552211
Among DNA adducts of cisplatin this requirement is very well accomplished by DPCLs.
[ "9", "33", "41" ]
83
11,188
0
false
Among DNA adducts of cisplatin this requirement is very well accomplished by DPCLs.
[]
Among DNA adducts of cisplatin this requirement is very well accomplished by DPCLs.
true
true
true
true
true
1,789
5
DISCUSSION
1
9
[ "B9", "B33", "B41" ]
17,329,374
pmid-2431763|pmid-6538808|pmid-3552211
Hence, a further systematic and detailed analysis of the efficiency of cisplatin and other antitumor platinum compounds to form DPCLs in cells and the role of these lesions in the mechanism underlying antitumor effects of platinum drugs is urgently needed.
[ "9", "33", "41" ]
256
11,189
0
false
Hence, a further systematic and detailed analysis of the efficiency of cisplatin and other antitumor platinum compounds to form DPCLs in cells and the role of these lesions in the mechanism underlying antitumor effects of platinum drugs is urgently needed.
[]
Hence, a further systematic and detailed analysis of the efficiency of cisplatin and other antitumor platinum compounds to form DPCLs in cells and the role of these lesions in the mechanism underlying antitumor effects of platinum drugs is urgently needed.
true
true
true
true
true
1,789
6
DISCUSSION
1
42
[ "B42", "B43" ]
17,329,374
NA|pmid-15196020
There are several reactive agents which produce CLs between DNA and proteins in van der Waals’ contact.
[ "42", "43" ]
103
11,190
0
false
There are several reactive agents which produce CLs between DNA and proteins in van der Waals’ contact.
[]
There are several reactive agents which produce CLs between DNA and proteins in van der Waals’ contact.
true
true
true
true
true
1,790
6
DISCUSSION
1
42
[ "B42", "B43" ]
17,329,374
NA|pmid-15196020
Thus, the cross-linking procedures involving these agents provide a tool for identification of proteins or protein domains closely positioned to DNA including mapping of protein-binding sites on DNA in vivo (42).
[ "42", "43" ]
212
11,191
1
false
Thus, the cross-linking procedures involving these agents provide a tool for identification of proteins or protein domains closely positioned to DNA including mapping of protein-binding sites on DNA in vivo.
[ "42" ]
Thus, the cross-linking procedures involving these agents provide a tool for identification of proteins or protein domains closely positioned to DNA including mapping of protein-binding sites on DNA in vivo.
true
true
true
true
true
1,790
6
DISCUSSION
1
43
[ "B42", "B43" ]
17,329,374
NA|pmid-15196020
The results of the present work support the view that cross-linking DNA and proteins by platinum complexes can be also applied to studies of specific protein–DNA interactions both in vitro and in vivo (43).
[ "42", "43" ]
206
11,192
1
false
The results of the present work support the view that cross-linking DNA and proteins by platinum complexes can be also applied to studies of specific protein–DNA interactions both in vitro and in vivo.
[ "43" ]
The results of the present work support the view that cross-linking DNA and proteins by platinum complexes can be also applied to studies of specific protein–DNA interactions both in vitro and in vivo.
true
true
true
true
true
1,790
0
INTRODUCTION
1
1
[ "b1", "b2", "b7", "b8", "b13", "b14", "b15", "b16", "b17", "b18", "b19", "b20", "b21", "b22", "b23" ]
16,973,899
pmid-11282478|pmid-7597027|pmid-380989|pmid-10400604|pmid-9184236|pmid-10556324|pmid-12675791|pmid-12692306|pmid-16230629|pmid-10635322|pmid-10973967|pmid-11809882|pmid-10900210|pmid-10049378|pmid-12381724
The mechanisms and regulation of gene expression in the Archaea have been studied during the past 25 years [reviewed in (1)].
[ "1", "2", "7", "8", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23" ]
125
11,193
0
false
The mechanisms and regulation of gene expression in the Archaea have been studied during the past 25 years.
[ "reviewed in (1)" ]
The mechanisms and regulation of gene expression in the Archaea have been studied during the past 25 years.
true
true
true
true
true
1,791
0
INTRODUCTION
1
1
[ "b1", "b2", "b7", "b8", "b13", "b14", "b15", "b16", "b17", "b18", "b19", "b20", "b21", "b22", "b23" ]
16,973,899
pmid-11282478|pmid-7597027|pmid-380989|pmid-10400604|pmid-9184236|pmid-10556324|pmid-12675791|pmid-12692306|pmid-16230629|pmid-10635322|pmid-10973967|pmid-11809882|pmid-10900210|pmid-10049378|pmid-12381724
However, our knowledge on them remains modest in comparison to what is known on transcription in the other two domains of life, the Eukarya and Bacteria.
[ "1", "2", "7", "8", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23" ]
153
11,194
0
false
However, our knowledge on them remains modest in comparison to what is known on transcription in the other two domains of life, the Eukarya and Bacteria.
[]
However, our knowledge on them remains modest in comparison to what is known on transcription in the other two domains of life, the Eukarya and Bacteria.
true
true
true
true
true
1,791
0
INTRODUCTION
1
1
[ "b1", "b2", "b7", "b8", "b13", "b14", "b15", "b16", "b17", "b18", "b19", "b20", "b21", "b22", "b23" ]
16,973,899
pmid-11282478|pmid-7597027|pmid-380989|pmid-10400604|pmid-9184236|pmid-10556324|pmid-12675791|pmid-12692306|pmid-16230629|pmid-10635322|pmid-10973967|pmid-11809882|pmid-10900210|pmid-10049378|pmid-12381724
Initial studies revealed that the archaeal basal transcription machinery resembles the core components of the eukaryal RNA polymerase (RNA Pol) II apparatus (2–7).
[ "1", "2", "7", "8", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23" ]
163
11,195
0
false
Initial studies revealed that the archaeal basal transcription machinery resembles the core components of the eukaryal RNA polymerase (RNA Pol) II apparatus.
[ "2–7" ]
Initial studies revealed that the archaeal basal transcription machinery resembles the core components of the eukaryal RNA polymerase (RNA Pol) II apparatus.
true
true
true
true
true
1,791
0
INTRODUCTION
1
1
[ "b1", "b2", "b7", "b8", "b13", "b14", "b15", "b16", "b17", "b18", "b19", "b20", "b21", "b22", "b23" ]
16,973,899
pmid-11282478|pmid-7597027|pmid-380989|pmid-10400604|pmid-9184236|pmid-10556324|pmid-12675791|pmid-12692306|pmid-16230629|pmid-10635322|pmid-10973967|pmid-11809882|pmid-10900210|pmid-10049378|pmid-12381724
Through the establishment of in vitro transcription systems for some archaea (8–13), it became possible to identify the archaeal factors necessary for specific initiation of transcription.
[ "1", "2", "7", "8", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23" ]
188
11,196
0
false
Through the establishment of in vitro transcription systems for some archaea, it became possible to identify the archaeal factors necessary for specific initiation of transcription.
[ "8–13" ]
Through the establishment of in vitro transcription systems for some archaea, it became possible to identify the archaeal factors necessary for specific initiation of transcription.
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INTRODUCTION
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Consisting of only the TATA-binding protein (TBP), transcription factor B (TFB), homologous to the eukaryotic TFIIB, and the RNA polymerase, a multi-subunit enzyme, the minimal archaeal transcription pre-initiation complex appears to be a simplified version of the eukaryotic RNA Pol II system.
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Consisting of only the TATA-binding protein (TBP), transcription factor B (TFB), homologous to the eukaryotic TFIIB, and the RNA polymerase, a multi-subunit enzyme, the minimal archaeal transcription pre-initiation complex appears to be a simplified version of the eukaryotic RNA Pol II system.
[]
Consisting of only the TATA-binding protein (TBP), transcription factor B (TFB), homologous to the eukaryotic TFIIB, and the RNA polymerase, a multi-subunit enzyme, the minimal archaeal transcription pre-initiation complex appears to be a simplified version of the eukaryotic RNA Pol II system.
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true
true
1,791
0
INTRODUCTION
1
1
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With the ongoing genome sequencing projects many transcription regulators could be identified in archaeal genomes.
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With the ongoing genome sequencing projects many transcription regulators could be identified in archaeal genomes.
[]
With the ongoing genome sequencing projects many transcription regulators could be identified in archaeal genomes.
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INTRODUCTION
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Surprisingly, many of them were homologs to the members of the bacterial Lrp-like regulator family (14,15).
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Surprisingly, many of them were homologs to the members of the bacterial Lrp-like regulator family.
[ "14,15" ]
Surprisingly, many of them were homologs to the members of the bacterial Lrp-like regulator family.
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