Datasets:
vgainullin
/
xciting_data

Dataset card Data Studio Files
xet
 Community
1
paragraph_index
int64
sec
string
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int64
cites
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sentences
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cited_sentence
string
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cit_qc
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lgtm
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__index_level_0__
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0
INTRODUCTION
1
6
[ "B1 B2 B3", "B4 B5 B6 B7", "B6", "B8", "B6", "B9 B10 B11 B12 B13 B14 B15" ]
17,344,318
pmid-9097727|pmid-10630639|pmid-9407023|pmid-10921899|pmid-15829953|pmid-15372092|NA|pmid-15372092|pmid-9233789|pmid-15372092|pmid-9727977|pmid-10201372|pmid-10318916|pmid-10514384|pmid-12183361|pmid-12200448|pmid-15592430|pmid-9097727|pmid-10630639|pmid-9407023|pmid-10921899|pmid-15829953|pmid-15372092|NA
Nuclear β-catenin binds to transcription factors such as those belonging to the T-cell-specific transcription factor/lymphoid enhancer-binding factor (TCF/LEF) family, and activates the transcription of target genes (6), such as the genes encoding cyclin D1, c-myc, matrix metalloproteinase-7, neuronal cell adhesion mol...
[ "1–3", "4–7", "6", "8", "6", "9–15" ]
441
3,900
1
false
Nuclear β-catenin binds to transcription factors such as those belonging to the T-cell-specific transcription factor/lymphoid enhancer-binding factor (TCF/LEF) family, and activates the transcription of target genes, such as the genes encoding cyclin D1, c-myc, matrix metalloproteinase-7, neuronal cell adhesion molecul...
[ "6", "9–15" ]
Nuclear β-catenin binds to transcription factors such as those belonging to the T-cell-specific transcription factor/lymphoid enhancer-binding factor (TCF/LEF) family, and activates the transcription of target genes, such as the genes encoding cyclin D1, c-myc, matrix metalloproteinase-7, neuronal cell adhesion molecul...
true
true
true
true
true
655
1
INTRODUCTION
1
16
[ "B16", "B17", "B18 B19 B20 B21", "B22", "B23", "B24", "B25", "B26", "B27", "B28", "B29", "B30", "B22" ]
17,344,318
pmid-9783587|pmid-10375506|pmid-10775268|pmid-10906119|pmid-11050151|pmid-10769018|pmid-11532957|pmid-14638683|pmid-11983685|pmid-16344550|pmid-11955446|pmid-16565090|pmid-16630820|pmid-16510874|pmid-12466281|pmid-11532957|pmid-15988012|pmid-16513642|pmid-12481024
In the absence of β-catenin binding, TCF/LEF transcription factors repress Wnt target gene transcription by recruiting transcription corepressors such as Groucho/TLE, CtBP and HDAC (16,17).
[ "16", "17", "18–21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "22" ]
189
3,901
0
false
In the absence of β-catenin binding, TCF/LEF transcription factors repress Wnt target gene transcription by recruiting transcription corepressors such as Groucho/TLE, CtBP and HDAC.
[ "16,17" ]
In the absence of β-catenin binding, TCF/LEF transcription factors repress Wnt target gene transcription by recruiting transcription corepressors such as Groucho/TLE, CtBP and HDAC.
true
true
true
true
true
656
1
INTRODUCTION
1
16
[ "B16", "B17", "B18 B19 B20 B21", "B22", "B23", "B24", "B25", "B26", "B27", "B28", "B29", "B30", "B22" ]
17,344,318
pmid-9783587|pmid-10375506|pmid-10775268|pmid-10906119|pmid-11050151|pmid-10769018|pmid-11532957|pmid-14638683|pmid-11983685|pmid-16344550|pmid-11955446|pmid-16565090|pmid-16630820|pmid-16510874|pmid-12466281|pmid-11532957|pmid-15988012|pmid-16513642|pmid-12481024
In response to Wnt signaling, β-catenin accumulates, binds to TCF/LEF transcription factors and converts the repressor complex into a transcriptional activator complex by displacement of the corepressors from TCF/LEF and recruitment of additional transcription coactivators.
[ "16", "17", "18–21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "22" ]
274
3,902
0
false
In response to Wnt signaling, β-catenin accumulates, binds to TCF/LEF transcription factors and converts the repressor complex into a transcriptional activator complex by displacement of the corepressors from TCF/LEF and recruitment of additional transcription coactivators.
[]
In response to Wnt signaling, β-catenin accumulates, binds to TCF/LEF transcription factors and converts the repressor complex into a transcriptional activator complex by displacement of the corepressors from TCF/LEF and recruitment of additional transcription coactivators.
true
true
true
true
true
656
1
INTRODUCTION
1
18–21
[ "B16", "B17", "B18 B19 B20 B21", "B22", "B23", "B24", "B25", "B26", "B27", "B28", "B29", "B30", "B22" ]
17,344,318
pmid-9783587|pmid-10375506|pmid-10775268|pmid-10906119|pmid-11050151|pmid-10769018|pmid-11532957|pmid-14638683|pmid-11983685|pmid-16344550|pmid-11955446|pmid-16565090|pmid-16630820|pmid-16510874|pmid-12466281|pmid-11532957|pmid-15988012|pmid-16513642|pmid-12481024
These additional coactivators include histone acetyltransferase p300/CBP (18–21), the SWI/SNF ATPase subunit Brg-1 (22), p 160 coactivator GRIP1 (23), histone methyltransferase CARM1(24), CoCoA (25), Legless (26), MED12 (27), Parafibromin/Hyrax (28), TRRAP/TIP60, ISW1, MLL/Set1 (29) and the LIM protein FHL2 (30).
[ "16", "17", "18–21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "22" ]
314
3,903
1
false
These additional coactivators include histone acetyltransferase p300/CBP, the SWI/SNF ATPase subunit Brg-1, p 160 coactivator GRIP1, histone methyltransferase CARM1, CoCoA, Legless, MED12, Parafibromin/Hyrax, TRRAP/TIP60, ISW1, MLL/Set1 and the LIM protein FHL2.
[ "18–21", "22", "23", "24", "25", "26", "27", "28", "29", "30" ]
These additional coactivators include histone acetyltransferase p300/CBP, the SWI/SNF ATPase subunit Brg-1, p 160 coactivator GRIP1, histone methyltransferase CARM1, CoCoA, Legless, MED12, Parafibromin/Hyrax, TRRAP/TIP60, ISW1, MLL/Set1 and the LIM protein FHL2.
true
true
true
true
true
656
1
INTRODUCTION
1
16
[ "B16", "B17", "B18 B19 B20 B21", "B22", "B23", "B24", "B25", "B26", "B27", "B28", "B29", "B30", "B22" ]
17,344,318
pmid-9783587|pmid-10375506|pmid-10775268|pmid-10906119|pmid-11050151|pmid-10769018|pmid-11532957|pmid-14638683|pmid-11983685|pmid-16344550|pmid-11955446|pmid-16565090|pmid-16630820|pmid-16510874|pmid-12466281|pmid-11532957|pmid-15988012|pmid-16513642|pmid-12481024
Each transcription coactivator contributes to a signal transduction pathway which transmits the activating signal from the DNA-bound transcriptional activator protein to specific downstream targets in the transcription machinery.
[ "16", "17", "18–21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "22" ]
229
3,904
0
false
Each transcription coactivator contributes to a signal transduction pathway which transmits the activating signal from the DNA-bound transcriptional activator protein to specific downstream targets in the transcription machinery.
[]
Each transcription coactivator contributes to a signal transduction pathway which transmits the activating signal from the DNA-bound transcriptional activator protein to specific downstream targets in the transcription machinery.
true
true
true
true
true
656
1
INTRODUCTION
1
22
[ "B16", "B17", "B18 B19 B20 B21", "B22", "B23", "B24", "B25", "B26", "B27", "B28", "B29", "B30", "B22" ]
17,344,318
pmid-9783587|pmid-10375506|pmid-10775268|pmid-10906119|pmid-11050151|pmid-10769018|pmid-11532957|pmid-14638683|pmid-11983685|pmid-16344550|pmid-11955446|pmid-16565090|pmid-16630820|pmid-16510874|pmid-12466281|pmid-11532957|pmid-15988012|pmid-16513642|pmid-12481024
For example, a member of the SWI/SNF complex, Brg-1, participates in the remodeling of chromatin conformation around the promoter by means of an ATPase activity (22).
[ "16", "17", "18–21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "22" ]
166
3,905
1
false
For example, a member of the SWI/SNF complex, Brg-1, participates in the remodeling of chromatin conformation around the promoter by means of an ATPase activity.
[ "22" ]
For example, a member of the SWI/SNF complex, Brg-1, participates in the remodeling of chromatin conformation around the promoter by means of an ATPase activity.
true
true
true
true
true
656
1
INTRODUCTION
1
16
[ "B16", "B17", "B18 B19 B20 B21", "B22", "B23", "B24", "B25", "B26", "B27", "B28", "B29", "B30", "B22" ]
17,344,318
pmid-9783587|pmid-10375506|pmid-10775268|pmid-10906119|pmid-11050151|pmid-10769018|pmid-11532957|pmid-14638683|pmid-11983685|pmid-16344550|pmid-11955446|pmid-16565090|pmid-16630820|pmid-16510874|pmid-12466281|pmid-11532957|pmid-15988012|pmid-16513642|pmid-12481024
Here, we report the identification of GRIP1-associated coactivator, GAC63, as a novel coactivator for β-catenin.
[ "16", "17", "18–21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "22" ]
112
3,906
0
false
Here, we report the identification of GRIP1-associated coactivator, GAC63, as a novel coactivator for β-catenin.
[]
Here, we report the identification of GRIP1-associated coactivator, GAC63, as a novel coactivator for β-catenin.
true
true
true
true
true
656
2
INTRODUCTION
1
31
[ "B31", "B31 B32 B33 B34", "B18 B19 B20 B21 B22 B23 B24 B25" ]
17,344,318
pmid-15988012|pmid-15988012|pmid-11916967|pmid-11792709|pmid-10987273|pmid-10775268|pmid-10906119|pmid-11050151|pmid-10769018|pmid-11532957|pmid-14638683|pmid-11983685|pmid-16344550|pmid-10409434|pmid-11906820|pmid-15988012|pmid-11906820
GAC63, also known as HUEL, has recently been identified as a nuclear receptor (NR) coactivator (31).
[ "31", "31–34", "18–25" ]
100
3,907
1
false
GAC63, also known as HUEL, has recently been identified as a nuclear receptor (NR) coactivator.
[ "31" ]
GAC63, also known as HUEL, has recently been identified as a nuclear receptor (NR) coactivator.
true
true
true
true
true
657
2
INTRODUCTION
1
31
[ "B31", "B31 B32 B33 B34", "B18 B19 B20 B21 B22 B23 B24 B25" ]
17,344,318
pmid-15988012|pmid-15988012|pmid-11916967|pmid-11792709|pmid-10987273|pmid-10775268|pmid-10906119|pmid-11050151|pmid-10769018|pmid-11532957|pmid-14638683|pmid-11983685|pmid-16344550|pmid-10409434|pmid-11906820|pmid-15988012|pmid-11906820
GAC63 interacts with the bHLH-PAS domain of p160 coactivators as well as the ligand-binding domain of some NRs, such as estrogen receptor (ER) and androgen receptor (AR).
[ "31", "31–34", "18–25" ]
170
3,908
0
false
GAC63 interacts with the bHLH-PAS domain of p160 coactivators as well as the ligand-binding domain of some NRs, such as estrogen receptor (ER) and androgen receptor (AR).
[]
GAC63 interacts with the bHLH-PAS domain of p160 coactivators as well as the ligand-binding domain of some NRs, such as estrogen receptor (ER) and androgen receptor (AR).
true
true
true
true
true
657
2
INTRODUCTION
1
31
[ "B31", "B31 B32 B33 B34", "B18 B19 B20 B21 B22 B23 B24 B25" ]
17,344,318
pmid-15988012|pmid-15988012|pmid-11916967|pmid-11792709|pmid-10987273|pmid-10775268|pmid-10906119|pmid-11050151|pmid-10769018|pmid-11532957|pmid-14638683|pmid-11983685|pmid-16344550|pmid-10409434|pmid-11906820|pmid-15988012|pmid-11906820
Over-expression of GAC63 enhanced transcriptional activation by NRs in a hormone-dependent manner.
[ "31", "31–34", "18–25" ]
98
3,909
0
false
Over-expression of GAC63 enhanced transcriptional activation by NRs in a hormone-dependent manner.
[]
Over-expression of GAC63 enhanced transcriptional activation by NRs in a hormone-dependent manner.
true
true
true
true
true
657
2
INTRODUCTION
1
31
[ "B31", "B31 B32 B33 B34", "B18 B19 B20 B21 B22 B23 B24 B25" ]
17,344,318
pmid-15988012|pmid-15988012|pmid-11916967|pmid-11792709|pmid-10987273|pmid-10775268|pmid-10906119|pmid-11050151|pmid-10769018|pmid-11532957|pmid-14638683|pmid-11983685|pmid-16344550|pmid-10409434|pmid-11906820|pmid-15988012|pmid-11906820
Although GAC63 can interact with NR directly, its coactivator function depends on the presence of a p160 coactivator with an intact N-terminal bHLH-PAS domain.
[ "31", "31–34", "18–25" ]
159
3,910
0
false
Although GAC63 can interact with NR directly, its coactivator function depends on the presence of a p160 coactivator with an intact N-terminal bHLH-PAS domain.
[]
Although GAC63 can interact with NR directly, its coactivator function depends on the presence of a p160 coactivator with an intact N-terminal bHLH-PAS domain.
true
true
true
true
true
657
2
INTRODUCTION
1
31
[ "B31", "B31 B32 B33 B34", "B18 B19 B20 B21 B22 B23 B24 B25" ]
17,344,318
pmid-15988012|pmid-15988012|pmid-11916967|pmid-11792709|pmid-10987273|pmid-10775268|pmid-10906119|pmid-11050151|pmid-10769018|pmid-11532957|pmid-14638683|pmid-11983685|pmid-16344550|pmid-10409434|pmid-11906820|pmid-15988012|pmid-11906820
Thus, it functions as a secondary coactivator in NR-mediated gene transcription.
[ "31", "31–34", "18–25" ]
80
3,911
0
false
Thus, it functions as a secondary coactivator in NR-mediated gene transcription.
[]
Thus, it functions as a secondary coactivator in NR-mediated gene transcription.
true
true
true
true
true
657
2
INTRODUCTION
1
31–34
[ "B31", "B31 B32 B33 B34", "B18 B19 B20 B21 B22 B23 B24 B25" ]
17,344,318
pmid-15988012|pmid-15988012|pmid-11916967|pmid-11792709|pmid-10987273|pmid-10775268|pmid-10906119|pmid-11050151|pmid-10769018|pmid-11532957|pmid-14638683|pmid-11983685|pmid-16344550|pmid-10409434|pmid-11906820|pmid-15988012|pmid-11906820
A link between GAC63 and β-catenin was first suggested by the findings that both GAC63 and β-catenin interact with androgen receptor (AR) and enhance AR function in an androgen-dependent manner (31–34).
[ "31", "31–34", "18–25" ]
202
3,912
1
false
A link between GAC63 and β-catenin was first suggested by the findings that both GAC63 and β-catenin interact with androgen receptor (AR) and enhance AR function in an androgen-dependent manner.
[ "31–34" ]
A link between GAC63 and β-catenin was first suggested by the findings that both GAC63 and β-catenin interact with androgen receptor (AR) and enhance AR function in an androgen-dependent manner.
true
true
true
true
true
657
2
INTRODUCTION
1
18–25
[ "B31", "B31 B32 B33 B34", "B18 B19 B20 B21 B22 B23 B24 B25" ]
17,344,318
pmid-15988012|pmid-15988012|pmid-11916967|pmid-11792709|pmid-10987273|pmid-10775268|pmid-10906119|pmid-11050151|pmid-10769018|pmid-11532957|pmid-14638683|pmid-11983685|pmid-16344550|pmid-10409434|pmid-11906820|pmid-15988012|pmid-11906820
Furthermore, a variety of NR coactivators, such as CBP/p300, Brg-1, p160 coactivators, CARM1 and CoCoA, also function as coactivators in TCF/LEF-dependent gene transcription (18–25).
[ "31", "31–34", "18–25" ]
182
3,913
1
false
Furthermore, a variety of NR coactivators, such as CBP/p300, Brg-1, p160 coactivators, CARM1 and CoCoA, also function as coactivators in TCF/LEF-dependent gene transcription.
[ "18–25" ]
Furthermore, a variety of NR coactivators, such as CBP/p300, Brg-1, p160 coactivators, CARM1 and CoCoA, also function as coactivators in TCF/LEF-dependent gene transcription.
true
true
true
true
true
657
2
INTRODUCTION
1
31
[ "B31", "B31 B32 B33 B34", "B18 B19 B20 B21 B22 B23 B24 B25" ]
17,344,318
pmid-15988012|pmid-15988012|pmid-11916967|pmid-11792709|pmid-10987273|pmid-10775268|pmid-10906119|pmid-11050151|pmid-10769018|pmid-11532957|pmid-14638683|pmid-11983685|pmid-16344550|pmid-10409434|pmid-11906820|pmid-15988012|pmid-11906820
Because of these connections, we decided to test whether GAC63 also acts as a coactivator in TCF/LEF-mediated gene transcription.
[ "31", "31–34", "18–25" ]
129
3,914
0
false
Because of these connections, we decided to test whether GAC63 also acts as a coactivator in TCF/LEF-mediated gene transcription.
[]
Because of these connections, we decided to test whether GAC63 also acts as a coactivator in TCF/LEF-mediated gene transcription.
true
true
true
true
true
657
0
DISCUSSION
1
1–7
[ "B1 B2 B3 B4 B5 B6 B7" ]
17,344,318
pmid-9097727|pmid-10630639|pmid-9407023|pmid-10921899|pmid-15829953|pmid-15372092|NA|pmid-15372092|pmid-9233789|pmid-15372092|pmid-9727977|pmid-10201372|pmid-10318916|pmid-10514384|pmid-12183361|pmid-12200448|pmid-15592430|pmid-9097727|pmid-10630639|pmid-9407023|pmid-10921899|pmid-15829953|pmid-15372092|NA
The Wnt signaling pathway plays important roles in multiple developmental processes and cancer (1–7).
[ "1–7" ]
101
3,915
1
false
The Wnt signaling pathway plays important roles in multiple developmental processes and cancer.
[ "1–7" ]
The Wnt signaling pathway plays important roles in multiple developmental processes and cancer.
true
true
true
true
true
658
0
DISCUSSION
1
1–7
[ "B1 B2 B3 B4 B5 B6 B7" ]
17,344,318
pmid-9097727|pmid-10630639|pmid-9407023|pmid-10921899|pmid-15829953|pmid-15372092|NA|pmid-15372092|pmid-9233789|pmid-15372092|pmid-9727977|pmid-10201372|pmid-10318916|pmid-10514384|pmid-12183361|pmid-12200448|pmid-15592430|pmid-9097727|pmid-10630639|pmid-9407023|pmid-10921899|pmid-15829953|pmid-15372092|NA
Upon Wnt signaling, β-catenin associates with TCF/LEF transcription factors and recruits a variety of transcriptional coactivators to the promoter/enhancer regions of Wnt-responsive genes.
[ "1–7" ]
188
3,916
0
false
Upon Wnt signaling, β-catenin associates with TCF/LEF transcription factors and recruits a variety of transcriptional coactivators to the promoter/enhancer regions of Wnt-responsive genes.
[]
Upon Wnt signaling, β-catenin associates with TCF/LEF transcription factors and recruits a variety of transcriptional coactivators to the promoter/enhancer regions of Wnt-responsive genes.
true
true
true
true
true
658
0
DISCUSSION
1
1–7
[ "B1 B2 B3 B4 B5 B6 B7" ]
17,344,318
pmid-9097727|pmid-10630639|pmid-9407023|pmid-10921899|pmid-15829953|pmid-15372092|NA|pmid-15372092|pmid-9233789|pmid-15372092|pmid-9727977|pmid-10201372|pmid-10318916|pmid-10514384|pmid-12183361|pmid-12200448|pmid-15592430|pmid-9097727|pmid-10630639|pmid-9407023|pmid-10921899|pmid-15829953|pmid-15372092|NA
Here we report that GAC63 is a novel binding partner and coactivator of β-catenin.
[ "1–7" ]
82
3,917
0
false
Here we report that GAC63 is a novel binding partner and coactivator of β-catenin.
[]
Here we report that GAC63 is a novel binding partner and coactivator of β-catenin.
true
true
true
true
true
658
0
DISCUSSION
1
1–7
[ "B1 B2 B3 B4 B5 B6 B7" ]
17,344,318
pmid-9097727|pmid-10630639|pmid-9407023|pmid-10921899|pmid-15829953|pmid-15372092|NA|pmid-15372092|pmid-9233789|pmid-15372092|pmid-9727977|pmid-10201372|pmid-10318916|pmid-10514384|pmid-12183361|pmid-12200448|pmid-15592430|pmid-9097727|pmid-10630639|pmid-9407023|pmid-10921899|pmid-15829953|pmid-15372092|NA
GAC63 binds β-catenin in vitro and in vivo, but does not bind directly to LEF1 (Figure 1).
[ "1–7" ]
90
3,918
0
false
GAC63 binds β-catenin in vitro and in vivo, but does not bind directly to LEF1 (Figure 1).
[]
GAC63 binds β-catenin in vitro and in vivo, but does not bind directly to LEF1.
true
true
true
true
true
658
0
DISCUSSION
1
1–7
[ "B1 B2 B3 B4 B5 B6 B7" ]
17,344,318
pmid-9097727|pmid-10630639|pmid-9407023|pmid-10921899|pmid-15829953|pmid-15372092|NA|pmid-15372092|pmid-9233789|pmid-15372092|pmid-9727977|pmid-10201372|pmid-10318916|pmid-10514384|pmid-12183361|pmid-12200448|pmid-15592430|pmid-9097727|pmid-10630639|pmid-9407023|pmid-10921899|pmid-15829953|pmid-15372092|NA
Over-expression of GAC63 enhanced TCF/LEF-mediated transcription in a β-catenin-dependent manner (Figure 3).
[ "1–7" ]
108
3,919
0
false
Over-expression of GAC63 enhanced TCF/LEF-mediated transcription in a β-catenin-dependent manner (Figure 3).
[]
Over-expression of GAC63 enhanced TCF/LEF-mediated transcription in a β-catenin-dependent manner (Figure 3).
true
true
true
true
true
658
0
DISCUSSION
1
1–7
[ "B1 B2 B3 B4 B5 B6 B7" ]
17,344,318
pmid-9097727|pmid-10630639|pmid-9407023|pmid-10921899|pmid-15829953|pmid-15372092|NA|pmid-15372092|pmid-9233789|pmid-15372092|pmid-9727977|pmid-10201372|pmid-10318916|pmid-10514384|pmid-12183361|pmid-12200448|pmid-15592430|pmid-9097727|pmid-10630639|pmid-9407023|pmid-10921899|pmid-15829953|pmid-15372092|NA
Taken together, our data suggest that GAC63 functions as a secondary coactivator in TCF/LEF-mediated transcriptional activation, that is, its coactivator function depends on the presence of β-catenin.
[ "1–7" ]
200
3,920
0
false
Taken together, our data suggest that GAC63 functions as a secondary coactivator in TCF/LEF-mediated transcriptional activation, that is, its coactivator function depends on the presence of β-catenin.
[]
Taken together, our data suggest that GAC63 functions as a secondary coactivator in TCF/LEF-mediated transcriptional activation, that is, its coactivator function depends on the presence of β-catenin.
true
true
true
true
true
658
0
DISCUSSION
1
1–7
[ "B1 B2 B3 B4 B5 B6 B7" ]
17,344,318
pmid-9097727|pmid-10630639|pmid-9407023|pmid-10921899|pmid-15829953|pmid-15372092|NA|pmid-15372092|pmid-9233789|pmid-15372092|pmid-9727977|pmid-10201372|pmid-10318916|pmid-10514384|pmid-12183361|pmid-12200448|pmid-15592430|pmid-9097727|pmid-10630639|pmid-9407023|pmid-10921899|pmid-15829953|pmid-15372092|NA
Moreover, upon LiCl treatment, endogenous GAC63 is recruited to the promoter regions of endogenous Wnt target genes, such as cyclin D1, FGF20 and DKK1 (Figure 4).
[ "1–7" ]
162
3,921
0
false
Moreover, upon LiCl treatment, endogenous GAC63 is recruited to the promoter regions of endogenous Wnt target genes, such as cyclin D1, FGF20 and DKK1 (Figure 4).
[]
Moreover, upon LiCl treatment, endogenous GAC63 is recruited to the promoter regions of endogenous Wnt target genes, such as cyclin D1, FGF20 and DKK1 (Figure 4).
true
true
true
true
true
658
0
DISCUSSION
1
1–7
[ "B1 B2 B3 B4 B5 B6 B7" ]
17,344,318
pmid-9097727|pmid-10630639|pmid-9407023|pmid-10921899|pmid-15829953|pmid-15372092|NA|pmid-15372092|pmid-9233789|pmid-15372092|pmid-9727977|pmid-10201372|pmid-10318916|pmid-10514384|pmid-12183361|pmid-12200448|pmid-15592430|pmid-9097727|pmid-10630639|pmid-9407023|pmid-10921899|pmid-15829953|pmid-15372092|NA
In addition, reduction of endogenous GAC63 by siRNA inhibited the TCF/LEF- and β-catenin-mediated expression of the cyclin D1 gene by 40–50% in a cell line with constitutively high levels of β-catenin and cyclin D1 expression (Figure 5).
[ "1–7" ]
237
3,922
0
false
In addition, reduction of endogenous GAC63 by siRNA inhibited the TCF/LEF- and β-catenin-mediated expression of the cyclin D1 gene by 40–50% in a cell line with constitutively high levels of β-catenin and cyclin D1 expression (Figure 5).
[]
In addition, reduction of endogenous GAC63 by siRNA inhibited the TCF/LEF- and β-catenin-mediated expression of the cyclin D1 gene by 40–50% in a cell line with constitutively high levels of β-catenin and cyclin D1 expression (Figure 5).
true
true
true
true
true
658
0
DISCUSSION
1
1–7
[ "B1 B2 B3 B4 B5 B6 B7" ]
17,344,318
pmid-9097727|pmid-10630639|pmid-9407023|pmid-10921899|pmid-15829953|pmid-15372092|NA|pmid-15372092|pmid-9233789|pmid-15372092|pmid-9727977|pmid-10201372|pmid-10318916|pmid-10514384|pmid-12183361|pmid-12200448|pmid-15592430|pmid-9097727|pmid-10630639|pmid-9407023|pmid-10921899|pmid-15829953|pmid-15372092|NA
The lack of complete inhibition by siRNA could be due to residual GAC63, or the compensatory effects by other transcription coactivators, such as CBP/p300, Brg-1, GRIP1, CARM1 and CoCoA, which also bind to β-catenin and serve as secondary coactivators for TCF/LEF transcription factors.
[ "1–7" ]
286
3,923
0
false
The lack of complete inhibition by siRNA could be due to residual GAC63, or the compensatory effects by other transcription coactivators, such as CBP/p300, Brg-1, GRIP1, CARM1 and CoCoA, which also bind to β-catenin and serve as secondary coactivators for TCF/LEF transcription factors.
[]
The lack of complete inhibition by siRNA could be due to residual GAC63, or the compensatory effects by other transcription coactivators, such as CBP/p300, Brg-1, GRIP1, CARM1 and CoCoA, which also bind to β-catenin and serve as secondary coactivators for TCF/LEF transcription factors.
true
true
true
true
true
658
0
DISCUSSION
1
1–7
[ "B1 B2 B3 B4 B5 B6 B7" ]
17,344,318
pmid-9097727|pmid-10630639|pmid-9407023|pmid-10921899|pmid-15829953|pmid-15372092|NA|pmid-15372092|pmid-9233789|pmid-15372092|pmid-9727977|pmid-10201372|pmid-10318916|pmid-10514384|pmid-12183361|pmid-12200448|pmid-15592430|pmid-9097727|pmid-10630639|pmid-9407023|pmid-10921899|pmid-15829953|pmid-15372092|NA
Furthermore, GAC63 could be recruited to other regulatory sites on the cyclin D1 promoter in addition to the TCF/LEF-binding site; therefore, it is possible that the reduced cyclin D1 expression observed when GAC63 levels are reduced by siRNA could be due to reduced GAC63 interactions at the TCF/LEF site and other regu...
[ "1–7" ]
333
3,924
0
false
Furthermore, GAC63 could be recruited to other regulatory sites on the cyclin D1 promoter in addition to the TCF/LEF-binding site; therefore, it is possible that the reduced cyclin D1 expression observed when GAC63 levels are reduced by siRNA could be due to reduced GAC63 interactions at the TCF/LEF site and other regu...
[]
Furthermore, GAC63 could be recruited to other regulatory sites on the cyclin D1 promoter in addition to the TCF/LEF-binding site; therefore, it is possible that the reduced cyclin D1 expression observed when GAC63 levels are reduced by siRNA could be due to reduced GAC63 interactions at the TCF/LEF site and other regu...
true
true
true
true
true
658
0
DISCUSSION
1
1–7
[ "B1 B2 B3 B4 B5 B6 B7" ]
17,344,318
pmid-9097727|pmid-10630639|pmid-9407023|pmid-10921899|pmid-15829953|pmid-15372092|NA|pmid-15372092|pmid-9233789|pmid-15372092|pmid-9727977|pmid-10201372|pmid-10318916|pmid-10514384|pmid-12183361|pmid-12200448|pmid-15592430|pmid-9097727|pmid-10630639|pmid-9407023|pmid-10921899|pmid-15829953|pmid-15372092|NA
While we do not know whether GAC63 is required for β-catenin-mediated up-regulation of cyclin D1 expression in all regulatory settings, our data as a whole make a compelling case that GAC63 plays an important role in β-catenin- and TCF/LEF-mediated transcription.
[ "1–7" ]
263
3,925
0
false
While we do not know whether GAC63 is required for β-catenin-mediated up-regulation of cyclin D1 expression in all regulatory settings, our data as a whole make a compelling case that GAC63 plays an important role in β-catenin- and TCF/LEF-mediated transcription.
[]
While we do not know whether GAC63 is required for β-catenin-mediated up-regulation of cyclin D1 expression in all regulatory settings, our data as a whole make a compelling case that GAC63 plays an important role in β-catenin- and TCF/LEF-mediated transcription.
true
true
true
true
true
658
0
DISCUSSION
1
1–7
[ "B1 B2 B3 B4 B5 B6 B7" ]
17,344,318
pmid-9097727|pmid-10630639|pmid-9407023|pmid-10921899|pmid-15829953|pmid-15372092|NA|pmid-15372092|pmid-9233789|pmid-15372092|pmid-9727977|pmid-10201372|pmid-10318916|pmid-10514384|pmid-12183361|pmid-12200448|pmid-15592430|pmid-9097727|pmid-10630639|pmid-9407023|pmid-10921899|pmid-15829953|pmid-15372092|NA
We therefore conclude that GAC63 is a physiological component of TCF/LEF- and β-catenin-mediated transactivation, and is important for optimal transcriptional activation mediated by β-catenin and TCF/LEF in at least some cases.
[ "1–7" ]
227
3,926
0
false
We therefore conclude that GAC63 is a physiological component of TCF/LEF- and β-catenin-mediated transactivation, and is important for optimal transcriptional activation mediated by β-catenin and TCF/LEF in at least some cases.
[]
We therefore conclude that GAC63 is a physiological component of TCF/LEF- and β-catenin-mediated transactivation, and is important for optimal transcriptional activation mediated by β-catenin and TCF/LEF in at least some cases.
true
true
true
true
true
658
1
DISCUSSION
1
31
[ "B31", "B37", "B38" ]
17,344,318
pmid-9783587|pmid-10375506|pmid-10775268|pmid-10906119|pmid-11050151|pmid-10769018|pmid-11532957|pmid-14638683|pmid-11983685|pmid-16344550|pmid-11955446|pmid-16565090|pmid-16630820|pmid-16510874|pmid-12466281|pmid-11532957|pmid-15988012|pmid-16513642|pmid-12481024
In previous studies, GAC63 has been shown to function as a secondary coactivator for NRs by cooperating with p160 coactivators (31).
[ "31", "37", "38" ]
132
3,927
1
false
In previous studies, GAC63 has been shown to function as a secondary coactivator for NRs by cooperating with p160 coactivators.
[ "31" ]
In previous studies, GAC63 has been shown to function as a secondary coactivator for NRs by cooperating with p160 coactivators.
true
true
true
true
true
659
1
DISCUSSION
1
31
[ "B31", "B37", "B38" ]
17,344,318
pmid-9783587|pmid-10375506|pmid-10775268|pmid-10906119|pmid-11050151|pmid-10769018|pmid-11532957|pmid-14638683|pmid-11983685|pmid-16344550|pmid-11955446|pmid-16565090|pmid-16630820|pmid-16510874|pmid-12466281|pmid-11532957|pmid-15988012|pmid-16513642|pmid-12481024
The current study shows that GAC63 functions as a secondary coactivator for another class of transcription factor, TCF/LEF, by cooperating with β-catenin.
[ "31", "37", "38" ]
154
3,928
0
false
The current study shows that GAC63 functions as a secondary coactivator for another class of transcription factor, TCF/LEF, by cooperating with β-catenin.
[]
The current study shows that GAC63 functions as a secondary coactivator for another class of transcription factor, TCF/LEF, by cooperating with β-catenin.
true
true
true
true
true
659
1
DISCUSSION
1
31
[ "B31", "B37", "B38" ]
17,344,318
pmid-9783587|pmid-10375506|pmid-10775268|pmid-10906119|pmid-11050151|pmid-10769018|pmid-11532957|pmid-14638683|pmid-11983685|pmid-16344550|pmid-11955446|pmid-16565090|pmid-16630820|pmid-16510874|pmid-12466281|pmid-11532957|pmid-15988012|pmid-16513642|pmid-12481024
also works as a primary coactivator for the aryl hydrocarbon receptor (AHR), i.e.
[ "31", "37", "38" ]
81
3,929
0
false
also works as a primary coactivator for the aryl hydrocarbon receptor (AHR), i.e.
[]
also works as a primary coactivator for the aryl hydrocarbon receptor (AHR), i.e.
false
true
true
true
false
659
1
DISCUSSION
1
37
[ "B31", "B37", "B38" ]
17,344,318
pmid-9783587|pmid-10375506|pmid-10775268|pmid-10906119|pmid-11050151|pmid-10769018|pmid-11532957|pmid-14638683|pmid-11983685|pmid-16344550|pmid-11955446|pmid-16565090|pmid-16630820|pmid-16510874|pmid-12466281|pmid-11532957|pmid-15988012|pmid-16513642|pmid-12481024
it binds directly to AHR (37).
[ "31", "37", "38" ]
30
3,930
1
false
it binds directly to AHR.
[ "37" ]
it binds directly to AHR.
false
true
true
true
false
659
1
DISCUSSION
1
31
[ "B31", "B37", "B38" ]
17,344,318
pmid-9783587|pmid-10375506|pmid-10775268|pmid-10906119|pmid-11050151|pmid-10769018|pmid-11532957|pmid-14638683|pmid-11983685|pmid-16344550|pmid-11955446|pmid-16565090|pmid-16630820|pmid-16510874|pmid-12466281|pmid-11532957|pmid-15988012|pmid-16513642|pmid-12481024
Thus, GAC63 functions as a general transcriptional coactivator for multiple signaling pathways.
[ "31", "37", "38" ]
95
3,931
0
false
Thus, GAC63 functions as a general transcriptional coactivator for multiple signaling pathways.
[]
Thus, GAC63 functions as a general transcriptional coactivator for multiple signaling pathways.
true
true
true
true
true
659
1
DISCUSSION
1
31
[ "B31", "B37", "B38" ]
17,344,318
pmid-9783587|pmid-10375506|pmid-10775268|pmid-10906119|pmid-11050151|pmid-10769018|pmid-11532957|pmid-14638683|pmid-11983685|pmid-16344550|pmid-11955446|pmid-16565090|pmid-16630820|pmid-16510874|pmid-12466281|pmid-11532957|pmid-15988012|pmid-16513642|pmid-12481024
However, we cannot rule out the possibility that GAC63 could also act as corepressor in certain conditions.
[ "31", "37", "38" ]
107
3,932
0
false
However, we cannot rule out the possibility that GAC63 could also act as corepressor in certain conditions.
[]
However, we cannot rule out the possibility that GAC63 could also act as corepressor in certain conditions.
true
true
true
true
true
659
1
DISCUSSION
1
31
[ "B31", "B37", "B38" ]
17,344,318
pmid-9783587|pmid-10375506|pmid-10775268|pmid-10906119|pmid-11050151|pmid-10769018|pmid-11532957|pmid-14638683|pmid-11983685|pmid-16344550|pmid-11955446|pmid-16565090|pmid-16630820|pmid-16510874|pmid-12466281|pmid-11532957|pmid-15988012|pmid-16513642|pmid-12481024
A number of proteins have been shown to act as either coactivator or corepressor in a promoter-specific manner.
[ "31", "37", "38" ]
111
3,933
0
false
A number of proteins have been shown to act as either coactivator or corepressor in a promoter-specific manner.
[]
A number of proteins have been shown to act as either coactivator or corepressor in a promoter-specific manner.
true
true
true
true
true
659
1
DISCUSSION
1
31
[ "B31", "B37", "B38" ]
17,344,318
pmid-9783587|pmid-10375506|pmid-10775268|pmid-10906119|pmid-11050151|pmid-10769018|pmid-11532957|pmid-14638683|pmid-11983685|pmid-16344550|pmid-11955446|pmid-16565090|pmid-16630820|pmid-16510874|pmid-12466281|pmid-11532957|pmid-15988012|pmid-16513642|pmid-12481024
For example, members of the p160 coactivators, such as GRIP1, function as glucocorticoid receptor (GR) coactivators.
[ "31", "37", "38" ]
116
3,934
0
false
For example, members of the p160 coactivators, such as GRIP1, function as glucocorticoid receptor (GR) coactivators.
[]
For example, members of the p160 coactivators, such as GRIP1, function as glucocorticoid receptor (GR) coactivators.
true
true
true
true
true
659
1
DISCUSSION
1
38
[ "B31", "B37", "B38" ]
17,344,318
pmid-9783587|pmid-10375506|pmid-10775268|pmid-10906119|pmid-11050151|pmid-10769018|pmid-11532957|pmid-14638683|pmid-11983685|pmid-16344550|pmid-11955446|pmid-16565090|pmid-16630820|pmid-16510874|pmid-12466281|pmid-11532957|pmid-15988012|pmid-16513642|pmid-12481024
However, at the promoters of certain GR target genes that are repressed by hormone-activated GR, such as the human collagenase-3 gene and osteocalcin gene, GRIP1 acts as a GR corepressor (38).
[ "31", "37", "38" ]
192
3,935
1
false
However, at the promoters of certain GR target genes that are repressed by hormone-activated GR, such as the human collagenase-3 gene and osteocalcin gene, GRIP1 acts as a GR corepressor.
[ "38" ]
However, at the promoters of certain GR target genes that are repressed by hormone-activated GR, such as the human collagenase-3 gene and osteocalcin gene, GRIP1 acts as a GR corepressor.
true
true
true
true
true
659
2
DISCUSSION
1
35
[ "B35", "B39", "B31", "B39" ]
17,344,318
pmid-15988012|pmid-15988012|pmid-11916967|pmid-11792709|pmid-10987273|pmid-10775268|pmid-10906119|pmid-11050151|pmid-10769018|pmid-11532957|pmid-14638683|pmid-11983685|pmid-16344550|pmid-10409434|pmid-11906820|pmid-15988012|pmid-11906820
GAC63 functions as a coactivator in multiple signaling pathways; however, the mechanisms by which GAC63 contributes to transcriptional activation are yet to be established.
[ "35", "39", "31", "39" ]
172
3,936
0
false
GAC63 functions as a coactivator in multiple signaling pathways; however, the mechanisms by which GAC63 contributes to transcriptional activation are yet to be established.
[]
GAC63 functions as a coactivator in multiple signaling pathways; however, the mechanisms by which GAC63 contributes to transcriptional activation are yet to be established.
true
true
true
true
true
660
2
DISCUSSION
1
35
[ "B35", "B39", "B31", "B39" ]
17,344,318
pmid-15988012|pmid-15988012|pmid-11916967|pmid-11792709|pmid-10987273|pmid-10775268|pmid-10906119|pmid-11050151|pmid-10769018|pmid-11532957|pmid-14638683|pmid-11983685|pmid-16344550|pmid-10409434|pmid-11906820|pmid-15988012|pmid-11906820
GAC63 has an N-terminal region containing a zinc-finger-like motif, a central domain containing two leucine-zipper-like motifs, and a C-terminal region with a LXXLL motif and an acidic region (35).
[ "35", "39", "31", "39" ]
197
3,937
1
false
GAC63 has an N-terminal region containing a zinc-finger-like motif, a central domain containing two leucine-zipper-like motifs, and a C-terminal region with a LXXLL motif and an acidic region.
[ "35" ]
GAC63 has an N-terminal region containing a zinc-finger-like motif, a central domain containing two leucine-zipper-like motifs, and a C-terminal region with a LXXLL motif and an acidic region.
true
true
true
true
true
660
2
DISCUSSION
1
35
[ "B35", "B39", "B31", "B39" ]
17,344,318
pmid-15988012|pmid-15988012|pmid-11916967|pmid-11792709|pmid-10987273|pmid-10775268|pmid-10906119|pmid-11050151|pmid-10769018|pmid-11532957|pmid-14638683|pmid-11983685|pmid-16344550|pmid-10409434|pmid-11906820|pmid-15988012|pmid-11906820
One region of the GAC63 protein (amino acids 127–196) was shown to have sequence similarity (34%) to the DNA-binding domain (amino acids 21–95) of the XPA DNA repair protein (SWISS-PROT accession no.
[ "35", "39", "31", "39" ]
199
3,938
0
false
One region of the GAC63 protein (amino acids 127–196) was shown to have sequence similarity (34%) to the DNA-binding domain (amino acids 21–95) of the XPA DNA repair protein (SWISS-PROT accession no.
[]
One region of the GAC63 protein (amino acids 127–196) was shown to have sequence similarity to the DNA-binding domain of the XPA DNA repair protein (SWISS-PROT accession no.
true
true
true
true
true
660
2
DISCUSSION
1
39
[ "B35", "B39", "B31", "B39" ]
17,344,318
pmid-15988012|pmid-15988012|pmid-11916967|pmid-11792709|pmid-10987273|pmid-10775268|pmid-10906119|pmid-11050151|pmid-10769018|pmid-11532957|pmid-14638683|pmid-11983685|pmid-16344550|pmid-10409434|pmid-11906820|pmid-15988012|pmid-11906820
Q64029) (39).
[ "35", "39", "31", "39" ]
13
3,939
1
false
Q64029).
[ "39" ]
Q64029).
true
true
true
true
true
660
2
DISCUSSION
1
35
[ "B35", "B39", "B31", "B39" ]
17,344,318
pmid-15988012|pmid-15988012|pmid-11916967|pmid-11792709|pmid-10987273|pmid-10775268|pmid-10906119|pmid-11050151|pmid-10769018|pmid-11532957|pmid-14638683|pmid-11983685|pmid-16344550|pmid-10409434|pmid-11906820|pmid-15988012|pmid-11906820
Another GAC63 region (amino acids 239–533) shares homology with members of the zinc transporter family.
[ "35", "39", "31", "39" ]
103
3,940
0
false
Another GAC63 region shares homology with members of the zinc transporter family.
[ "amino acids 239–533" ]
Another GAC63 region shares homology with members of the zinc transporter family.
true
true
true
true
true
660
2
DISCUSSION
1
35
[ "B35", "B39", "B31", "B39" ]
17,344,318
pmid-15988012|pmid-15988012|pmid-11916967|pmid-11792709|pmid-10987273|pmid-10775268|pmid-10906119|pmid-11050151|pmid-10769018|pmid-11532957|pmid-14638683|pmid-11983685|pmid-16344550|pmid-10409434|pmid-11906820|pmid-15988012|pmid-11906820
In fragment studies, the N-terminus and central region of GAC63 both bind GRIP1, while only the N-terminus binds β-catenin.
[ "35", "39", "31", "39" ]
123
3,941
0
false
In fragment studies, the N-terminus and central region of GAC63 both bind GRIP1, while only the N-terminus binds β-catenin.
[]
In fragment studies, the N-terminus and central region of GAC63 both bind GRIP1, while only the N-terminus binds β-catenin.
true
true
true
true
true
660
2
DISCUSSION
1
31
[ "B35", "B39", "B31", "B39" ]
17,344,318
pmid-15988012|pmid-15988012|pmid-11916967|pmid-11792709|pmid-10987273|pmid-10775268|pmid-10906119|pmid-11050151|pmid-10769018|pmid-11532957|pmid-14638683|pmid-11983685|pmid-16344550|pmid-10409434|pmid-11906820|pmid-15988012|pmid-11906820
When fused to Gal4 DNA-binding domain, the C-terminus of GAC63 showed weak autonomous transcriptional activation activity (31).
[ "35", "39", "31", "39" ]
127
3,942
1
false
When fused to Gal4 DNA-binding domain, the C-terminus of GAC63 showed weak autonomous transcriptional activation activity.
[ "31" ]
When fused to Gal4 DNA-binding domain, the C-terminus of GAC63 showed weak autonomous transcriptional activation activity.
true
true
true
true
true
660
2
DISCUSSION
1
39
[ "B35", "B39", "B31", "B39" ]
17,344,318
pmid-15988012|pmid-15988012|pmid-11916967|pmid-11792709|pmid-10987273|pmid-10775268|pmid-10906119|pmid-11050151|pmid-10769018|pmid-11532957|pmid-14638683|pmid-11983685|pmid-16344550|pmid-10409434|pmid-11906820|pmid-15988012|pmid-11906820
GAC63 also contains several nuclear localization signals and a nuclear-export-like signal; the human ortholog of GAC63, HUEL, has been shown to undergo nuclear translocation during S phase (39).
[ "35", "39", "31", "39" ]
194
3,943
1
false
GAC63 also contains several nuclear localization signals and a nuclear-export-like signal; the human ortholog of GAC63, HUEL, has been shown to undergo nuclear translocation during S phase.
[ "39" ]
GAC63 also contains several nuclear localization signals and a nuclear-export-like signal; the human ortholog of GAC63, HUEL, has been shown to undergo nuclear translocation during S phase.
true
true
true
true
true
660
3
DISCUSSION
1
18–21
[ "B18 B19 B20 B21", "B22", "B23", "B24", "B25", "B32", "B40 B41 B42 B43 B44 B45", "B40", "B46" ]
17,344,318
pmid-10775268|pmid-10906119|pmid-11050151|pmid-10769018|pmid-11532957|pmid-14638683|pmid-11983685|pmid-16344550|pmid-11916967|pmid-16126938|pmid-12588987|pmid-12944908|pmid-12972427|pmid-10607566|pmid-11533250|pmid-16126938|NA
β-Catenin has been shown to be a coactivator for TCF/LEF transcription factors as well as androgen receptor.
[ "18–21", "22", "23", "24", "25", "32", "40–45", "40", "46" ]
108
3,944
0
false
β-Catenin has been shown to be a coactivator for TCF/LEF transcription factors as well as androgen receptor.
[]
β-Catenin has been shown to be a coactivator for TCF/LEF transcription factors as well as androgen receptor.
false
true
true
true
false
661
3
DISCUSSION
1
18–21
[ "B18 B19 B20 B21", "B22", "B23", "B24", "B25", "B32", "B40 B41 B42 B43 B44 B45", "B40", "B46" ]
17,344,318
pmid-10775268|pmid-10906119|pmid-11050151|pmid-10769018|pmid-11532957|pmid-14638683|pmid-11983685|pmid-16344550|pmid-11916967|pmid-16126938|pmid-12588987|pmid-12944908|pmid-12972427|pmid-10607566|pmid-11533250|pmid-16126938|NA
This provides a mechanism for crosstalk between the Wnt and AR signaling pathways.
[ "18–21", "22", "23", "24", "25", "32", "40–45", "40", "46" ]
82
3,945
0
false
This provides a mechanism for crosstalk between the Wnt and AR signaling pathways.
[]
This provides a mechanism for crosstalk between the Wnt and AR signaling pathways.
true
true
true
true
true
661
3
DISCUSSION
1
18–21
[ "B18 B19 B20 B21", "B22", "B23", "B24", "B25", "B32", "B40 B41 B42 B43 B44 B45", "B40", "B46" ]
17,344,318
pmid-10775268|pmid-10906119|pmid-11050151|pmid-10769018|pmid-11532957|pmid-14638683|pmid-11983685|pmid-16344550|pmid-11916967|pmid-16126938|pmid-12588987|pmid-12944908|pmid-12972427|pmid-10607566|pmid-11533250|pmid-16126938|NA
In addition, these two pathways share a number of transcriptional coactivators, such as CBP/p300 (18–21), Brg-1 (22), p160 coactivators (23), CARM1 (24) and CoCoA (25).
[ "18–21", "22", "23", "24", "25", "32", "40–45", "40", "46" ]
168
3,946
1
false
In addition, these two pathways share a number of transcriptional coactivators, such as CBP/p300, Brg-1, p160 coactivators, CARM1 and CoCoA.
[ "18–21", "22", "23", "24", "25" ]
In addition, these two pathways share a number of transcriptional coactivators, such as CBP/p300, Brg-1, p160 coactivators, CARM1 and CoCoA.
true
true
true
true
true
661
3
DISCUSSION
1
18–21
[ "B18 B19 B20 B21", "B22", "B23", "B24", "B25", "B32", "B40 B41 B42 B43 B44 B45", "B40", "B46" ]
17,344,318
pmid-10775268|pmid-10906119|pmid-11050151|pmid-10769018|pmid-11532957|pmid-14638683|pmid-11983685|pmid-16344550|pmid-11916967|pmid-16126938|pmid-12588987|pmid-12944908|pmid-12972427|pmid-10607566|pmid-11533250|pmid-16126938|NA
GAC63 provides yet another example of a transcriptional coactivator that is involved in both signaling pathways.
[ "18–21", "22", "23", "24", "25", "32", "40–45", "40", "46" ]
112
3,947
0
false
GAC63 provides yet another example of a transcriptional coactivator that is involved in both signaling pathways.
[]
GAC63 provides yet another example of a transcriptional coactivator that is involved in both signaling pathways.
true
true
true
true
true
661
3
DISCUSSION
1
18–21
[ "B18 B19 B20 B21", "B22", "B23", "B24", "B25", "B32", "B40 B41 B42 B43 B44 B45", "B40", "B46" ]
17,344,318
pmid-10775268|pmid-10906119|pmid-11050151|pmid-10769018|pmid-11532957|pmid-14638683|pmid-11983685|pmid-16344550|pmid-11916967|pmid-16126938|pmid-12588987|pmid-12944908|pmid-12972427|pmid-10607566|pmid-11533250|pmid-16126938|NA
Furthermore, members of the NR superfamily, such as androgen receptor (AR), thyroid hormone receptor (TR) and retinoic acid receptor (RAR), have been shown to interfere with the Wnt signaling pathway (32,40–45).
[ "18–21", "22", "23", "24", "25", "32", "40–45", "40", "46" ]
211
3,948
0
false
Furthermore, members of the NR superfamily, such as androgen receptor (AR), thyroid hormone receptor (TR) and retinoic acid receptor (RAR), have been shown to interfere with the Wnt signaling pathway.
[ "32,40–45" ]
Furthermore, members of the NR superfamily, such as androgen receptor (AR), thyroid hormone receptor (TR) and retinoic acid receptor (RAR), have been shown to interfere with the Wnt signaling pathway.
true
true
true
true
true
661
3
DISCUSSION
1
18–21
[ "B18 B19 B20 B21", "B22", "B23", "B24", "B25", "B32", "B40 B41 B42 B43 B44 B45", "B40", "B46" ]
17,344,318
pmid-10775268|pmid-10906119|pmid-11050151|pmid-10769018|pmid-11532957|pmid-14638683|pmid-11983685|pmid-16344550|pmid-11916967|pmid-16126938|pmid-12588987|pmid-12944908|pmid-12972427|pmid-10607566|pmid-11533250|pmid-16126938|NA
The antagonistic effect by AR could be due to the competition for common transcriptional coactivators, in addition to other proposed mechanisms, such as increased degradation of β-catenin (40,46).
[ "18–21", "22", "23", "24", "25", "32", "40–45", "40", "46" ]
196
3,949
0
false
The antagonistic effect by AR could be due to the competition for common transcriptional coactivators, in addition to other proposed mechanisms, such as increased degradation of β-catenin.
[ "40,46" ]
The antagonistic effect by AR could be due to the competition for common transcriptional coactivators, in addition to other proposed mechanisms, such as increased degradation of β-catenin.
true
true
true
true
true
661
4
DISCUSSION
1
18
[ "B18", "B21", "B27 B28 B29", "B47", "B48" ]
17,344,318
pmid-10775268|pmid-10769018|pmid-16565090|pmid-16630820|pmid-16510874|NA|pmid-15782138
In our study, GAC63 bound to a β-catenin fragment consisting of Arm repeats 10–12 and the C-terminal activation domain.
[ "18", "21", "27–29", "47", "48" ]
119
3,950
0
false
In our study, GAC63 bound to a β-catenin fragment consisting of Arm repeats 10–12 and the C-terminal activation domain.
[]
In our study, GAC63 bound to a β-catenin fragment consisting of Arm repeats 10–12 and the C-terminal activation domain.
true
true
true
true
true
662
4
DISCUSSION
1
18
[ "B18", "B21", "B27 B28 B29", "B47", "B48" ]
17,344,318
pmid-10775268|pmid-10769018|pmid-16565090|pmid-16630820|pmid-16510874|NA|pmid-15782138
Several other proteins have been reported to bind to a similar β-catenin subdomain, and contribute to transcriptional activation.
[ "18", "21", "27–29", "47", "48" ]
129
3,951
0
false
Several other proteins have been reported to bind to a similar β-catenin subdomain, and contribute to transcriptional activation.
[]
Several other proteins have been reported to bind to a similar β-catenin subdomain, and contribute to transcriptional activation.
true
true
true
true
true
662
4
DISCUSSION
1
18
[ "B18", "B21", "B27 B28 B29", "B47", "B48" ]
17,344,318
pmid-10775268|pmid-10769018|pmid-16565090|pmid-16630820|pmid-16510874|NA|pmid-15782138
These proteins include CBP/p300, MED12, Parafibromin/Hyrax, TRRAP/TIP60, ISW1 and MLL/Set1 (18,21,27–29,47).
[ "18", "21", "27–29", "47", "48" ]
108
3,952
0
false
These proteins include CBP/p300, MED12, Parafibromin/Hyrax, TRRAP/TIP60, ISW1 and MLL/Set1.
[ "18,21,27–29,47" ]
These proteins include CBP/p300, MED12, Parafibromin/Hyrax, TRRAP/TIP60, ISW1 and MLL/Set1.
true
true
true
true
true
662
4
DISCUSSION
1
18
[ "B18", "B21", "B27 B28 B29", "B47", "B48" ]
17,344,318
pmid-10775268|pmid-10769018|pmid-16565090|pmid-16630820|pmid-16510874|NA|pmid-15782138
It remains to be determined whether these coactivators can bind to β-catenin at the same time and function synergistically as coactivators, or whether some of them may compete for binding and inhibit each other's function or play different roles on various promoters.
[ "18", "21", "27–29", "47", "48" ]
267
3,953
0
false
It remains to be determined whether these coactivators can bind to β-catenin at the same time and function synergistically as coactivators, or whether some of them may compete for binding and inhibit each other's function or play different roles on various promoters.
[]
It remains to be determined whether these coactivators can bind to β-catenin at the same time and function synergistically as coactivators, or whether some of them may compete for binding and inhibit each other's function or play different roles on various promoters.
true
true
true
true
true
662
4
DISCUSSION
1
48
[ "B18", "B21", "B27 B28 B29", "B47", "B48" ]
17,344,318
pmid-10775268|pmid-10769018|pmid-16565090|pmid-16630820|pmid-16510874|NA|pmid-15782138
For example, although CBP and p300 are closely related, they play opposite roles on the expression of some β-catenin target genes, such as survivin (48).
[ "18", "21", "27–29", "47", "48" ]
153
3,954
1
false
For example, although CBP and p300 are closely related, they play opposite roles on the expression of some β-catenin target genes, such as survivin.
[ "48" ]
For example, although CBP and p300 are closely related, they play opposite roles on the expression of some β-catenin target genes, such as survivin.
true
true
true
true
true
662
4
DISCUSSION
1
18
[ "B18", "B21", "B27 B28 B29", "B47", "B48" ]
17,344,318
pmid-10775268|pmid-10769018|pmid-16565090|pmid-16630820|pmid-16510874|NA|pmid-15782138
The small molecule ICG-001, which blocks the CBP–β-catenin interaction but not the p300–β-catenin interaction, inhibits survivin gene expression.
[ "18", "21", "27–29", "47", "48" ]
145
3,955
0
false
The small molecule ICG-001, which blocks the CBP–β-catenin interaction but not the p300–β-catenin interaction, inhibits survivin gene expression.
[]
The small molecule ICG-001, which blocks the CBP–β-catenin interaction but not the p300–β-catenin interaction, inhibits survivin gene expression.
true
true
true
true
true
662
4
DISCUSSION
1
18
[ "B18", "B21", "B27 B28 B29", "B47", "B48" ]
17,344,318
pmid-10775268|pmid-10769018|pmid-16565090|pmid-16630820|pmid-16510874|NA|pmid-15782138
In the absence of ICG-001, CBP is recruited to the survivin promoter, and promotes survivin gene expression; however, in the presence of ICG-001, there is less CBP on the survivin promoter but more p300 instead, which leads to concomitant recruitment of repressive elements and results in transcription repression.
[ "18", "21", "27–29", "47", "48" ]
314
3,956
0
false
In the absence of ICG-001, CBP is recruited to the survivin promoter, and promotes survivin gene expression; however, in the presence of ICG-001, there is less CBP on the survivin promoter but more p300 instead, which leads to concomitant recruitment of repressive elements and results in transcription repression.
[]
In the absence of ICG-001, CBP is recruited to the survivin promoter, and promotes survivin gene expression; however, in the presence of ICG-001, there is less CBP on the survivin promoter but more p300 instead, which leads to concomitant recruitment of repressive elements and results in transcription repression.
true
true
true
true
true
662
5
DISCUSSION
1
4–7
[ "B4 B5 B6 B7", "B9 B10 B11", "B49", "B35" ]
17,344,318
pmid-10921899|pmid-15829953|pmid-15372092|NA|pmid-9727977|pmid-10201372|pmid-10318916|pmid-12747878|pmid-10409434
Inappropriate activation of the Wnt signaling pathway occurs in many types of cancer, and is caused by mutations of many of the Wnt signaling components (4–7).
[ "4–7", "9–11", "49", "35" ]
159
3,957
1
false
Inappropriate activation of the Wnt signaling pathway occurs in many types of cancer, and is caused by mutations of many of the Wnt signaling components.
[ "4–7" ]
Inappropriate activation of the Wnt signaling pathway occurs in many types of cancer, and is caused by mutations of many of the Wnt signaling components.
true
true
true
true
true
663
5
DISCUSSION
1
4–7
[ "B4 B5 B6 B7", "B9 B10 B11", "B49", "B35" ]
17,344,318
pmid-10921899|pmid-15829953|pmid-15372092|NA|pmid-9727977|pmid-10201372|pmid-10318916|pmid-12747878|pmid-10409434
The two genes found most frequently mutated are adenomatous polyposis coli (APC) and β-catenin.
[ "4–7", "9–11", "49", "35" ]
95
3,958
0
false
The two genes found most frequently mutated are adenomatous polyposis coli (APC) and β-catenin.
[]
The two genes found most frequently mutated are adenomatous polyposis coli (APC) and β-catenin.
true
true
true
true
true
663
5
DISCUSSION
1
4–7
[ "B4 B5 B6 B7", "B9 B10 B11", "B49", "B35" ]
17,344,318
pmid-10921899|pmid-15829953|pmid-15372092|NA|pmid-9727977|pmid-10201372|pmid-10318916|pmid-12747878|pmid-10409434
These mutations generally lead to stabilization of β-catenin, and an over-activation of the Wnt signaling pathway.
[ "4–7", "9–11", "49", "35" ]
114
3,959
0
false
These mutations generally lead to stabilization of β-catenin, and an over-activation of the Wnt signaling pathway.
[]
These mutations generally lead to stabilization of β-catenin, and an over-activation of the Wnt signaling pathway.
true
true
true
true
true
663
5
DISCUSSION
1
9–11
[ "B4 B5 B6 B7", "B9 B10 B11", "B49", "B35" ]
17,344,318
pmid-10921899|pmid-15829953|pmid-15372092|NA|pmid-9727977|pmid-10201372|pmid-10318916|pmid-12747878|pmid-10409434
This over-activation is thought in part to promote oncogenesis through over-expression of Wnt-responsive genes, such as c-myc and cyclin D1 (9–11).
[ "4–7", "9–11", "49", "35" ]
147
3,960
1
false
This over-activation is thought in part to promote oncogenesis through over-expression of Wnt-responsive genes, such as c-myc and cyclin D1.
[ "9–11" ]
This over-activation is thought in part to promote oncogenesis through over-expression of Wnt-responsive genes, such as c-myc and cyclin D1.
true
true
true
true
true
663
5
DISCUSSION
1
4–7
[ "B4 B5 B6 B7", "B9 B10 B11", "B49", "B35" ]
17,344,318
pmid-10921899|pmid-15829953|pmid-15372092|NA|pmid-9727977|pmid-10201372|pmid-10318916|pmid-12747878|pmid-10409434
Since GAC63 cooperates with β-catenin to activate Wnt-responsive gene expression, GAC63 might play a role in the oncogenic processes.
[ "4–7", "9–11", "49", "35" ]
133
3,961
0
false
Since GAC63 cooperates with β-catenin to activate Wnt-responsive gene expression, GAC63 might play a role in the oncogenic processes.
[]
Since GAC63 cooperates with β-catenin to activate Wnt-responsive gene expression, GAC63 might play a role in the oncogenic processes.
true
true
true
true
true
663
5
DISCUSSION
1
49
[ "B4 B5 B6 B7", "B9 B10 B11", "B49", "B35" ]
17,344,318
pmid-10921899|pmid-15829953|pmid-15372092|NA|pmid-9727977|pmid-10201372|pmid-10318916|pmid-12747878|pmid-10409434
Furthermore, in DNA microarray studies, GAC63 (C4orf1) over-expression has been shown to be associated with lymph node metastasis of breast cancer (49).
[ "4–7", "9–11", "49", "35" ]
152
3,962
1
false
Furthermore, in DNA microarray studies, GAC63 (C4orf1) over-expression has been shown to be associated with lymph node metastasis of breast cancer.
[ "49" ]
Furthermore, in DNA microarray studies, GAC63 over-expression has been shown to be associated with lymph node metastasis of breast cancer.
true
true
true
true
true
663
5
DISCUSSION
1
35
[ "B4 B5 B6 B7", "B9 B10 B11", "B49", "B35" ]
17,344,318
pmid-10921899|pmid-15829953|pmid-15372092|NA|pmid-9727977|pmid-10201372|pmid-10318916|pmid-12747878|pmid-10409434
In addition, a distinct alternative transcript encoding GAC63 with a modified and truncated C-terminus was detected in the HT-1080 fibrosarcoma, G-401 Wilms tumor and SiHa cervical carcinoma cell lines (35).
[ "4–7", "9–11", "49", "35" ]
207
3,963
1
false
In addition, a distinct alternative transcript encoding GAC63 with a modified and truncated C-terminus was detected in the HT-1080 fibrosarcoma, G-401 Wilms tumor and SiHa cervical carcinoma cell lines.
[ "35" ]
In addition, a distinct alternative transcript encoding GAC63 with a modified and truncated C-terminus was detected in the HT-1080 fibrosarcoma, G-401 Wilms tumor and SiHa cervical carcinoma cell lines.
true
true
true
true
true
663
5
DISCUSSION
1
4–7
[ "B4 B5 B6 B7", "B9 B10 B11", "B49", "B35" ]
17,344,318
pmid-10921899|pmid-15829953|pmid-15372092|NA|pmid-9727977|pmid-10201372|pmid-10318916|pmid-12747878|pmid-10409434
These findings indicate that GAC63 might be involved in the development of cancer.
[ "4–7", "9–11", "49", "35" ]
82
3,964
0
false
These findings indicate that GAC63 might be involved in the development of cancer.
[]
These findings indicate that GAC63 might be involved in the development of cancer.
true
true
true
true
true
663
5
DISCUSSION
1
4–7
[ "B4 B5 B6 B7", "B9 B10 B11", "B49", "B35" ]
17,344,318
pmid-10921899|pmid-15829953|pmid-15372092|NA|pmid-9727977|pmid-10201372|pmid-10318916|pmid-12747878|pmid-10409434
The role of GAC63 in oncogenesis, and the mechanisms by which GAC63 contributes to oncogenesis are currently under investigation in our laboratory.
[ "4–7", "9–11", "49", "35" ]
147
3,965
0
false
The role of GAC63 in oncogenesis, and the mechanisms by which GAC63 contributes to oncogenesis are currently under investigation in our laboratory.
[]
The role of GAC63 in oncogenesis, and the mechanisms by which GAC63 contributes to oncogenesis are currently under investigation in our laboratory.
true
true
true
true
true
663
0
INTRODUCTION
1
1
[ "b1", "b2", "b8", "b5", "b7", "b8" ]
17,090,597
pmid-10864329|pmid-9335585|pmid-11485989|pmid-11485988|pmid-14871930|pmid-11485989|pmid-12052880|pmid-15932941|pmid-11485988|pmid-14871930|pmid-15932941|pmid-12052880|pmid-15932941
Spt-Ada-Gcn5-acetyltransferase (SAGA), a large multi-protein complex with Gcn5p-HAT (histone acetyltransferase) activity, is required for the normal transcription of ∼10% of yeast genes (1).
[ "1", "2", "8", "5", "7", "8" ]
190
3,966
1
false
Spt-Ada-Gcn5-acetyltransferase (SAGA), a large multi-protein complex with Gcn5p-HAT (histone acetyltransferase) activity, is required for the normal transcription of ∼10% of yeast genes.
[ "1" ]
Spt-Ada-Gcn5-acetyltransferase (SAGA), a large multi-protein complex with Gcn5p-HAT (histone acetyltransferase) activity, is required for the normal transcription of ∼10% of yeast genes.
true
true
true
true
true
664
0
INTRODUCTION
1
1
[ "b1", "b2", "b8", "b5", "b7", "b8" ]
17,090,597
pmid-10864329|pmid-9335585|pmid-11485989|pmid-11485988|pmid-14871930|pmid-11485989|pmid-12052880|pmid-15932941|pmid-11485988|pmid-14871930|pmid-15932941|pmid-12052880|pmid-15932941
The role of SAGA in transcriptional activation has been studied extensively at GAL1 (2–8).
[ "1", "2", "8", "5", "7", "8" ]
90
3,967
0
false
The role of SAGA in transcriptional activation has been studied extensively at GAL1.
[ "2–8" ]
The role of SAGA in transcriptional activation has been studied extensively at GAL1.
true
true
true
true
true
664
0
INTRODUCTION
1
1
[ "b1", "b2", "b8", "b5", "b7", "b8" ]
17,090,597
pmid-10864329|pmid-9335585|pmid-11485989|pmid-11485988|pmid-14871930|pmid-11485989|pmid-12052880|pmid-15932941|pmid-11485988|pmid-14871930|pmid-15932941|pmid-12052880|pmid-15932941
At the GAL1 promoter, the activator Gal4p first recruits SAGA to the upstream activating sequence (UAS), and then the UAS-bound SAGA facilitates recruitment of TATA-box binding protein (TBP) to the core promoter, thereby stimulating formation of preinitiation complex (PIC) and hence transcription (5,7,8).
[ "1", "2", "8", "5", "7", "8" ]
306
3,968
0
false
At the GAL1 promoter, the activator Gal4p first recruits SAGA to the upstream activating sequence (UAS), and then the UAS-bound SAGA facilitates recruitment of TATA-box binding protein (TBP) to the core promoter, thereby stimulating formation of preinitiation complex (PIC) and hence transcription.
[ "5,7,8" ]
At the GAL1 promoter, the activator Gal4p first recruits SAGA to the upstream activating sequence (UAS), and then the UAS-bound SAGA facilitates recruitment of TATA-box binding protein (TBP) to the core promoter, thereby stimulating formation of preinitiation complex (PIC) and hence transcription.
true
true
true
true
true
664
1
INTRODUCTION
1
9
[ "b9", "b10", "b11", "b15", "b16", "b17", "b18", "b19", "b10", "b16", "b10", "b16" ]
17,090,597
pmid-12052880|pmid-15932941|pmid-9736784|pmid-11487572|pmid-15932940|NA|pmid-9726987|pmid-11564863|pmid-15932941|pmid-15932940|pmid-15932941|pmid-15932940
Recently, Sgf73p has been biochemically identified as a new component of SAGA (9,10).
[ "9", "10", "11", "15", "16", "17", "18", "19", "10", "16", "10", "16" ]
85
3,969
0
false
Recently, Sgf73p has been biochemically identified as a new component of SAGA.
[ "9,10" ]
Recently, Sgf73p has been biochemically identified as a new component of SAGA.
true
true
true
true
true
665
1
INTRODUCTION
1
9
[ "b9", "b10", "b11", "b15", "b16", "b17", "b18", "b19", "b10", "b16", "b10", "b16" ]
17,090,597
pmid-12052880|pmid-15932941|pmid-9736784|pmid-11487572|pmid-15932940|NA|pmid-9726987|pmid-11564863|pmid-15932941|pmid-15932940|pmid-15932941|pmid-15932940
Sgf73p is a yeast homologue of the human Spinocerebellar ataxia type 7 (SCA7) gene product, ataxin-7 or Sca7p.
[ "9", "10", "11", "15", "16", "17", "18", "19", "10", "16", "10", "16" ]
110
3,970
0
false
Sgf73p is a yeast homologue of the human Spinocerebellar ataxia type 7 (SCA7) gene product, ataxin-7 or Sca7p.
[]
Sgf73p is a yeast homologue of the human Spinocerebellar ataxia type 7 (SCA7) gene product, ataxin-7 or Sca7p.
true
true
true
true
true
665
1
INTRODUCTION
1
9
[ "b9", "b10", "b11", "b15", "b16", "b17", "b18", "b19", "b10", "b16", "b10", "b16" ]
17,090,597
pmid-12052880|pmid-15932941|pmid-9736784|pmid-11487572|pmid-15932940|NA|pmid-9726987|pmid-11564863|pmid-15932941|pmid-15932940|pmid-15932941|pmid-15932940
It is one of the eight known autosomal dominant neurodegenerative disorders which are caused by CAG (that encodes glutamine, Q) nucleotide repeat expansions from <35 (non-pathogenic) to an extreme of 300 (pathogenic) copies (11–15).
[ "9", "10", "11", "15", "16", "17", "18", "19", "10", "16", "10", "16" ]
232
3,971
0
false
It is one of the eight known autosomal dominant neurodegenerative disorders which are caused by CAG (that encodes glutamine, Q) nucleotide repeat expansions from <35 (non-pathogenic) to an extreme of 300 (pathogenic) copies.
[ "11–15" ]
It is one of the eight known autosomal dominant neurodegenerative disorders which are caused by CAG (that encodes glutamine, Q) nucleotide repeat expansions from <35 (non-pathogenic) to an extreme of 300 (pathogenic) copies.
true
true
true
true
true
665
1
INTRODUCTION
1
9
[ "b9", "b10", "b11", "b15", "b16", "b17", "b18", "b19", "b10", "b16", "b10", "b16" ]
17,090,597
pmid-12052880|pmid-15932941|pmid-9736784|pmid-11487572|pmid-15932940|NA|pmid-9726987|pmid-11564863|pmid-15932941|pmid-15932940|pmid-15932941|pmid-15932940
However, it is not known how CAG nucleotide repeat expansion within ataxin-7 causes neurodegenerative diseases.
[ "9", "10", "11", "15", "16", "17", "18", "19", "10", "16", "10", "16" ]
111
3,972
0
false
However, it is not known how CAG nucleotide repeat expansion within ataxin-7 causes neurodegenerative diseases.
[]
However, it is not known how CAG nucleotide repeat expansion within ataxin-7 causes neurodegenerative diseases.
true
true
true
true
true
665
1
INTRODUCTION
1
9
[ "b9", "b10", "b11", "b15", "b16", "b17", "b18", "b19", "b10", "b16", "b10", "b16" ]
17,090,597
pmid-12052880|pmid-15932941|pmid-9736784|pmid-11487572|pmid-15932940|NA|pmid-9726987|pmid-11564863|pmid-15932941|pmid-15932940|pmid-15932941|pmid-15932940
Recent biochemical studies (16,17) have demonstrated that, like Sgf73p, wild-type ataxin-7 is a component of mammalian SPT3-TAFII31-GCN5L acetylase (STAGA) transcription coactivator complex (18,19), a human homologue of yeast SAGA complex, and it regulates HAT activity of STAGA and its interaction with activators.
[ "9", "10", "11", "15", "16", "17", "18", "19", "10", "16", "10", "16" ]
315
3,973
0
false
Recent biochemical studies have demonstrated that, like Sgf73p, wild-type ataxin-7 is a component of mammalian SPT3-TAFII31-GCN5L acetylase (STAGA) transcription coactivator complex, a human homologue of yeast SAGA complex, and it regulates HAT activity of STAGA and its interaction with activators.
[ "16,17", "18,19" ]
Recent biochemical studies have demonstrated that, like Sgf73p, wild-type ataxin-7 is a component of mammalian SPT3-TAFII31-GCN5L acetylase (STAGA) transcription coactivator complex, a human homologue of yeast SAGA complex, and it regulates HAT activity of STAGA and its interaction with activators.
true
true
true
true
true
665
1
INTRODUCTION
1
9
[ "b9", "b10", "b11", "b15", "b16", "b17", "b18", "b19", "b10", "b16", "b10", "b16" ]
17,090,597
pmid-12052880|pmid-15932941|pmid-9736784|pmid-11487572|pmid-15932940|NA|pmid-9726987|pmid-11564863|pmid-15932941|pmid-15932940|pmid-15932941|pmid-15932940
The poly(Q)-expanded ataxin-7 gets incorporated into STAGA as well as SAGA (10,16), but inhibits Gcn5p-HAT activities of both STAGA and SAGA (10,16), and thus alters gene expression, providing significant information on the molecular basis of poly(Q) disorders.
[ "9", "10", "11", "15", "16", "17", "18", "19", "10", "16", "10", "16" ]
261
3,974
0
false
The poly(Q)-expanded ataxin-7 gets incorporated into STAGA as well as SAGA, but inhibits Gcn5p-HAT activities of both STAGA and SAGA, and thus alters gene expression, providing significant information on the molecular basis of poly(Q) disorders.
[ "10,16", "10,16" ]
The poly(Q)-expanded ataxin-7 gets incorporated into STAGA as well as SAGA, but inhibits Gcn5p-HAT activities of both STAGA and SAGA, and thus alters gene expression, providing significant information on the molecular basis of poly(Q) disorders.
true
true
true
true
true
665
2
INTRODUCTION
1
10
[ "b10", "b16", "b17" ]
17,090,597
pmid-15932941|pmid-15932940|NA|pmid-9858534|pmid-11395403|pmid-16122420|pmid-9858534|pmid-11395403|pmid-16122420|pmid-10638745
Although previous biochemical studies (10,16,17) have defined the functional roles of Sgf73p and ataxin-7 in maintaining the overall structural integrities of SAGA and STAGA, respectively, and their HAT activities, the molecular role of Sgf73p or ataxin-7 in transcriptional regulation remains mostly unknown in vivo.
[ "10", "16", "17" ]
317
3,975
0
false
Although previous biochemical studies have defined the functional roles of Sgf73p and ataxin-7 in maintaining the overall structural integrities of SAGA and STAGA, respectively, and their HAT activities, the molecular role of Sgf73p or ataxin-7 in transcriptional regulation remains mostly unknown in vivo.
[ "10,16,17" ]
Although previous biochemical studies have defined the functional roles of Sgf73p and ataxin-7 in maintaining the overall structural integrities of SAGA and STAGA, respectively, and their HAT activities, the molecular role of Sgf73p or ataxin-7 in transcriptional regulation remains mostly unknown in vivo.
true
true
true
true
true
666
2
INTRODUCTION
1
10
[ "b10", "b16", "b17" ]
17,090,597
pmid-15932941|pmid-15932940|NA|pmid-9858534|pmid-11395403|pmid-16122420|pmid-9858534|pmid-11395403|pmid-16122420|pmid-10638745
Here, using a formaldehyde-based in vivo crosslinking and chromatin immunoprecipitation (ChIP) assay, we have analyzed the role of Sgf73p in recruitment of SAGA and formation of the PIC assembly (and hence transcription) at the SAGA-dependent promoter in Saccharomyces cerevisiae.
[ "10", "16", "17" ]
280
3,976
0
false
Here, using a formaldehyde-based in vivo crosslinking and chromatin immunoprecipitation (ChIP) assay, we have analyzed the role of Sgf73p in recruitment of SAGA and formation of the PIC assembly (and hence transcription) at the SAGA-dependent promoter in Saccharomyces cerevisiae.
[]
Here, using a formaldehyde-based in vivo crosslinking and chromatin immunoprecipitation (ChIP) assay, we have analyzed the role of Sgf73p in recruitment of SAGA and formation of the PIC assembly (and hence transcription) at the SAGA-dependent promoter in Saccharomyces cerevisiae.
true
true
true
true
true
666
2
INTRODUCTION
1
10
[ "b10", "b16", "b17" ]
17,090,597
pmid-15932941|pmid-15932940|NA|pmid-9858534|pmid-11395403|pmid-16122420|pmid-9858534|pmid-11395403|pmid-16122420|pmid-10638745
Further, we have determined the role of histone H3 acetylation or the HAT activity of SAGA in regulation of the PIC formation at the SAGA-dependent promoters in vivo.
[ "10", "16", "17" ]
166
3,977
0
false
Further, we have determined the role of histone H3 acetylation or the HAT activity of SAGA in regulation of the PIC formation at the SAGA-dependent promoters in vivo.
[]
Further, we have determined the role of histone H3 acetylation or the HAT activity of SAGA in regulation of the PIC formation at the SAGA-dependent promoters in vivo.
true
true
true
true
true
666
2
INTRODUCTION
1
10
[ "b10", "b16", "b17" ]
17,090,597
pmid-15932941|pmid-15932940|NA|pmid-9858534|pmid-11395403|pmid-16122420|pmid-9858534|pmid-11395403|pmid-16122420|pmid-10638745
Our results reveal that Sgf73p is required for SAGA recruitment and stimulates formation of the PIC assembly at the SAGA-dependent promoters.
[ "10", "16", "17" ]
141
3,978
0
false
Our results reveal that Sgf73p is required for SAGA recruitment and stimulates formation of the PIC assembly at the SAGA-dependent promoters.
[]
Our results reveal that Sgf73p is required for SAGA recruitment and stimulates formation of the PIC assembly at the SAGA-dependent promoters.
true
true
true
true
true
666
2
INTRODUCTION
1
10
[ "b10", "b16", "b17" ]
17,090,597
pmid-15932941|pmid-15932940|NA|pmid-9858534|pmid-11395403|pmid-16122420|pmid-9858534|pmid-11395403|pmid-16122420|pmid-10638745
Consistently, transcription of the SAGA-regulated genes is significantly impaired in Δsgf73.
[ "10", "16", "17" ]
92
3,979
0
false
Consistently, transcription of the SAGA-regulated genes is significantly impaired in Δsgf73.
[]
Consistently, transcription of the SAGA-regulated genes is significantly impaired in Δsgf73.
true
true
true
true
true
666
2
INTRODUCTION
1
10
[ "b10", "b16", "b17" ]
17,090,597
pmid-15932941|pmid-15932940|NA|pmid-9858534|pmid-11395403|pmid-16122420|pmid-9858534|pmid-11395403|pmid-16122420|pmid-10638745
Interestingly, PIC formation at the SAGA-regulated genes is differentially regulated by histone H3 acetylation or the HAT activity of SAGA in vivo.
[ "10", "16", "17" ]
147
3,980
0
false
Interestingly, PIC formation at the SAGA-regulated genes is differentially regulated by histone H3 acetylation or the HAT activity of SAGA in vivo.
[]
Interestingly, PIC formation at the SAGA-regulated genes is differentially regulated by histone H3 acetylation or the HAT activity of SAGA in vivo.
true
true
true
true
true
666
0
DISCUSSION
1
9
[ "b9", "b10", "b5", "b7", "b10", "b9", "b10" ]
17,090,597
pmid-10864329|pmid-9335585|pmid-11485989|pmid-11485988|pmid-14871930|pmid-11485989|pmid-12052880|pmid-15932941|pmid-11485988|pmid-14871930|pmid-15932941|pmid-12052880|pmid-15932941
Although Sgf73p has been shown to be a new component of SAGA on the basis of the biochemical studies (9,10), it is not known whether Sgf73p is a SAGA component in vivo.
[ "9", "10", "5", "7", "10", "9", "10" ]
168
3,981
0
false
Although Sgf73p has been shown to be a new component of SAGA on the basis of the biochemical studies, it is not known whether Sgf73p is a SAGA component in vivo.
[ "9,10" ]
Although Sgf73p has been shown to be a new component of SAGA on the basis of the biochemical studies, it is not known whether Sgf73p is a SAGA component in vivo.
true
true
true
true
true
667
0
DISCUSSION
1
9
[ "b9", "b10", "b5", "b7", "b10", "b9", "b10" ]
17,090,597
pmid-10864329|pmid-9335585|pmid-11485989|pmid-11485988|pmid-14871930|pmid-11485989|pmid-12052880|pmid-15932941|pmid-11485988|pmid-14871930|pmid-15932941|pmid-12052880|pmid-15932941
If so, it would be recruited along with other SAGA components to the GAL1 UAS but not to its core promoter, since SAGA is specifically recruited to the GAL1 UAS by the activator Gal4p (5,7).
[ "9", "10", "5", "7", "10", "9", "10" ]
190
3,982
0
false
If so, it would be recruited along with other SAGA components to the GAL1 UAS but not to its core promoter, since SAGA is specifically recruited to the GAL1 UAS by the activator Gal4p.
[ "5,7" ]
If so, it would be recruited along with other SAGA components to the GAL1 UAS but not to its core promoter, since SAGA is specifically recruited to the GAL1 UAS by the activator Gal4p.
true
true
true
true
true
667
0
DISCUSSION
1
9
[ "b9", "b10", "b5", "b7", "b10", "b9", "b10" ]
17,090,597
pmid-10864329|pmid-9335585|pmid-11485989|pmid-11485988|pmid-14871930|pmid-11485989|pmid-12052880|pmid-15932941|pmid-11485988|pmid-14871930|pmid-15932941|pmid-12052880|pmid-15932941
Here, we show that, like SAGA, Sgf73p is recruited to the GAL1 UAS, but not core promoter, or even to the minimal Gal4p-binding sites in a plasmid, implicating Sgf73p as a SAGA component in vivo.
[ "9", "10", "5", "7", "10", "9", "10" ]
195
3,983
0
false
Here, we show that, like SAGA, Sgf73p is recruited to the GAL1 UAS, but not core promoter, or even to the minimal Gal4p-binding sites in a plasmid, implicating Sgf73p as a SAGA component in vivo.
[]
Here, we show that, like SAGA, Sgf73p is recruited to the GAL1 UAS, but not core promoter, or even to the minimal Gal4p-binding sites in a plasmid, implicating Sgf73p as a SAGA component in vivo.
true
true
true
true
true
667
0
DISCUSSION
1
10
[ "b9", "b10", "b5", "b7", "b10", "b9", "b10" ]
17,090,597
pmid-10864329|pmid-9335585|pmid-11485989|pmid-11485988|pmid-14871930|pmid-11485989|pmid-12052880|pmid-15932941|pmid-11485988|pmid-14871930|pmid-15932941|pmid-12052880|pmid-15932941
Furthermore, we show that the deletion of SGF73 significantly impairs recruitment of the SAGA complex, consistent with biochemical requirement of Sgf73p for SAGA integrity (10).
[ "9", "10", "5", "7", "10", "9", "10" ]
177
3,984
1
false
Furthermore, we show that the deletion of SGF73 significantly impairs recruitment of the SAGA complex, consistent with biochemical requirement of Sgf73p for SAGA integrity.
[ "10" ]
Furthermore, we show that the deletion of SGF73 significantly impairs recruitment of the SAGA complex, consistent with biochemical requirement of Sgf73p for SAGA integrity.
true
true
true
true
true
667
0
DISCUSSION
1
9
[ "b9", "b10", "b5", "b7", "b10", "b9", "b10" ]
17,090,597
pmid-10864329|pmid-9335585|pmid-11485989|pmid-11485988|pmid-14871930|pmid-11485989|pmid-12052880|pmid-15932941|pmid-11485988|pmid-14871930|pmid-15932941|pmid-12052880|pmid-15932941
Thus, our results support the fact in vivo that Sgf73p is a SAGA component and is required for the structural integrity of SAGA, consistent with recent biochemical data (9,10).
[ "9", "10", "5", "7", "10", "9", "10" ]
176
3,985
0
false
Thus, our results support the fact in vivo that Sgf73p is a SAGA component and is required for the structural integrity of SAGA, consistent with recent biochemical data.
[ "9,10" ]
Thus, our results support the fact in vivo that Sgf73p is a SAGA component and is required for the structural integrity of SAGA, consistent with recent biochemical data.
true
true
true
true
true
667
1
DISCUSSION
0
null
null
17,090,597
pmid-12052880|pmid-15932941|pmid-9736784|pmid-11487572|pmid-15932940|NA|pmid-9726987|pmid-11564863|pmid-15932941|pmid-15932940|pmid-15932941|pmid-15932940
Since Sgf73p is essential for recruitment of SAGA, the PIC would thus not be formed at the SAGA-dependent promoters in Δsgf73.
null
126
3,986
0
false
null
null
Since Sgf73p is essential for recruitment of SAGA, the PIC would thus not be formed at the SAGA-dependent promoters in Δsgf73.
true
true
true
true
true
668
1
DISCUSSION
0
null
null
17,090,597
pmid-12052880|pmid-15932941|pmid-9736784|pmid-11487572|pmid-15932940|NA|pmid-9726987|pmid-11564863|pmid-15932941|pmid-15932940|pmid-15932941|pmid-15932940
Indeed, our study demonstrates that recruitment of the PIC components such as TBP and RNA polymerase II is significantly impaired at the core promoters of the three representative SAGA-dependent genes, GAL1, ADH1 and PHO84, in the absence of Sgf73p.
null
249
3,987
0
false
null
null
Indeed, our study demonstrates that recruitment of the PIC components such as TBP and RNA polymerase II is significantly impaired at the core promoters of the three representative SAGA-dependent genes, GAL1, ADH1 and PHO84, in the absence of Sgf73p.
true
true
true
true
true
668
1
DISCUSSION
0
null
null
17,090,597
pmid-12052880|pmid-15932941|pmid-9736784|pmid-11487572|pmid-15932940|NA|pmid-9726987|pmid-11564863|pmid-15932941|pmid-15932940|pmid-15932941|pmid-15932940
Consistently, transcription of these genes is altered in Δsgf73.
null
64
3,988
0
false
null
null
Consistently, transcription of these genes is altered in Δsgf73.
true
true
true
true
true
668
1
DISCUSSION
0
null
null
17,090,597
pmid-12052880|pmid-15932941|pmid-9736784|pmid-11487572|pmid-15932940|NA|pmid-9726987|pmid-11564863|pmid-15932941|pmid-15932940|pmid-15932941|pmid-15932940
However, whether Sgf73p plays a dual role in assembling PIC by interacting with the component(s) of PIC as well as maintaining structural integrity of SAGA to regulate gene expression remains to be elucidated.
null
209
3,989
0
false
null
null
However, whether Sgf73p plays a dual role in assembling PIC by interacting with the component(s) of PIC as well as maintaining structural integrity of SAGA to regulate gene expression remains to be elucidated.
true
true
true
true
true
668
2
DISCUSSION
1
3
[ "b3", "b38", "b41", "b3", "b38", "b41", "b42" ]
17,090,597
pmid-15932941|pmid-15932940|NA|pmid-9858534|pmid-11395403|pmid-16122420|pmid-9858534|pmid-11395403|pmid-16122420|pmid-10638745
Previous studies (3,38–41) have demonstrated the functional role of histone H3 acetylation at the promoters in regulation of transcriptional initiation.
[ "3", "38", "41", "3", "38", "41", "42" ]
152
3,990
0
false
Previous studies have demonstrated the functional role of histone H3 acetylation at the promoters in regulation of transcriptional initiation.
[ "3,38–41" ]
Previous studies have demonstrated the functional role of histone H3 acetylation at the promoters in regulation of transcriptional initiation.
true
true
true
true
true
669
2
DISCUSSION
1
3
[ "b3", "b38", "b41", "b3", "b38", "b41", "b42" ]
17,090,597
pmid-15932941|pmid-15932940|NA|pmid-9858534|pmid-11395403|pmid-16122420|pmid-9858534|pmid-11395403|pmid-16122420|pmid-10638745
Here, we demonstrate that all three SAGA-dependent promoters are acetylated at histone H3.
[ "3", "38", "41", "3", "38", "41", "42" ]
90
3,991
0
false
Here, we demonstrate that all three SAGA-dependent promoters are acetylated at histone H3.
[]
Here, we demonstrate that all three SAGA-dependent promoters are acetylated at histone H3.
true
true
true
true
true
669
2
DISCUSSION
1
3
[ "b3", "b38", "b41", "b3", "b38", "b41", "b42" ]
17,090,597
pmid-15932941|pmid-15932940|NA|pmid-9858534|pmid-11395403|pmid-16122420|pmid-9858534|pmid-11395403|pmid-16122420|pmid-10638745
Acetylation of histone H3 at these promoters is significantly lost in Δgcn5.
[ "3", "38", "41", "3", "38", "41", "42" ]
76
3,992
0
false
Acetylation of histone H3 at these promoters is significantly lost in Δgcn5.
[]
Acetylation of histone H3 at these promoters is significantly lost in Δgcn5.
true
true
true
true
true
669
2
DISCUSSION
1
3
[ "b3", "b38", "b41", "b3", "b38", "b41", "b42" ]
17,090,597
pmid-15932941|pmid-15932940|NA|pmid-9858534|pmid-11395403|pmid-16122420|pmid-9858534|pmid-11395403|pmid-16122420|pmid-10638745
However, formation of the PIC assembly at the GAL1 and ADH1 promoters is not altered in Δgcn5.
[ "3", "38", "41", "3", "38", "41", "42" ]
94
3,993
0
false
However, formation of the PIC assembly at the GAL1 and ADH1 promoters is not altered in Δgcn5.
[]
However, formation of the PIC assembly at the GAL1 and ADH1 promoters is not altered in Δgcn5.
true
true
true
true
true
669
2
DISCUSSION
1
3
[ "b3", "b38", "b41", "b3", "b38", "b41", "b42" ]
17,090,597
pmid-15932941|pmid-15932940|NA|pmid-9858534|pmid-11395403|pmid-16122420|pmid-9858534|pmid-11395403|pmid-16122420|pmid-10638745
Thus, our study reveals that histone H3 acetylation status does not regulate PIC formation at GAL1 and ADH1.
[ "3", "38", "41", "3", "38", "41", "42" ]
108
3,994
0
false
Thus, our study reveals that histone H3 acetylation status does not regulate PIC formation at GAL1 and ADH1.
[]
Thus, our study reveals that histone H3 acetylation status does not regulate PIC formation at GAL1 and ADH1.
true
true
true
true
true
669
2
DISCUSSION
1
3
[ "b3", "b38", "b41", "b3", "b38", "b41", "b42" ]
17,090,597
pmid-15932941|pmid-15932940|NA|pmid-9858534|pmid-11395403|pmid-16122420|pmid-9858534|pmid-11395403|pmid-16122420|pmid-10638745
In contrast, PIC formation is significantly reduced at the PHO84 promoter in Δgcn5, demonstrating the role of histone H3 acetylation in regulation of the PIC formation, consistent with previous studies (3,38–41).
[ "3", "38", "41", "3", "38", "41", "42" ]
212
3,995
0
false
In contrast, PIC formation is significantly reduced at the PHO84 promoter in Δgcn5, demonstrating the role of histone H3 acetylation in regulation of the PIC formation, consistent with previous studies.
[ "3,38–41" ]
In contrast, PIC formation is significantly reduced at the PHO84 promoter in Δgcn5, demonstrating the role of histone H3 acetylation in regulation of the PIC formation, consistent with previous studies.
true
true
true
true
true
669
2
DISCUSSION
1
3
[ "b3", "b38", "b41", "b3", "b38", "b41", "b42" ]
17,090,597
pmid-15932941|pmid-15932940|NA|pmid-9858534|pmid-11395403|pmid-16122420|pmid-9858534|pmid-11395403|pmid-16122420|pmid-10638745
Thus, our study reveals that histone H3 acetylation differentially regulates formation of the PIC assembly.
[ "3", "38", "41", "3", "38", "41", "42" ]
107
3,996
0
false
Thus, our study reveals that histone H3 acetylation differentially regulates formation of the PIC assembly.
[]
Thus, our study reveals that histone H3 acetylation differentially regulates formation of the PIC assembly.
true
true
true
true
true
669
2
DISCUSSION
1
3
[ "b3", "b38", "b41", "b3", "b38", "b41", "b42" ]
17,090,597
pmid-15932941|pmid-15932940|NA|pmid-9858534|pmid-11395403|pmid-16122420|pmid-9858534|pmid-11395403|pmid-16122420|pmid-10638745
However, the molecular basis for such differential roles of histone H3 acetylation in regulation of the PIC formation remains unknown.
[ "3", "38", "41", "3", "38", "41", "42" ]
134
3,997
0
false
However, the molecular basis for such differential roles of histone H3 acetylation in regulation of the PIC formation remains unknown.
[]
However, the molecular basis for such differential roles of histone H3 acetylation in regulation of the PIC formation remains unknown.
true
true
true
true
true
669
2
DISCUSSION
1
42
[ "b3", "b38", "b41", "b3", "b38", "b41", "b42" ]
17,090,597
pmid-15932941|pmid-15932940|NA|pmid-9858534|pmid-11395403|pmid-16122420|pmid-9858534|pmid-11395403|pmid-16122420|pmid-10638745
According to the ‘histone-code’ hypothesis (42), it is likely that histone H3 acetylation in combination with other histone modifications at the GAL1 and ADH1 promoters may contribute to the role of chromatin structure in PIC formation and hence transcriptional activation.
[ "3", "38", "41", "3", "38", "41", "42" ]
273
3,998
1
false
According to the ‘histone-code’ hypothesis, it is likely that histone H3 acetylation in combination with other histone modifications at the GAL1 and ADH1 promoters may contribute to the role of chromatin structure in PIC formation and hence transcriptional activation.
[ "42" ]
According to the ‘histone-code’ hypothesis, it is likely that histone H3 acetylation in combination with other histone modifications at the GAL1 and ADH1 promoters may contribute to the role of chromatin structure in PIC formation and hence transcriptional activation.
true
true
true
true
true
669
3
DISCUSSION
1
37
[ "b37" ]
17,090,597
pmid-15542822
Histones are evicted during active transcription in vivo (37).
[ "37" ]
62
3,999
1
false
Histones are evicted during active transcription in vivo.
[ "37" ]
Histones are evicted during active transcription in vivo.
true
true
true
true
true
670